id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_3bwtv5c24nhuhmr5lwk5fbquu4	Ioanna Tachmazidou	A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates	2013.0	6	.pdf	application/pdf	5251	620	62	Isolated populations can empower the identification of rare variation associated with complex Illumina HumanExome Beadchip, in search of functional coding variants associated with lipids variant in APOC3, with increased high-density lipoprotein and decreased triglycerides levels. discovery of this lipid traits signal at genome-wide significance in a small sample size. MANOLIS study (Supplementary Table S1), we find genomewide significant evidence for association with common-frequency Genome-wide statistical association evidence for HDL in MANOLIS. Table 1 | CETP variants associated with HDL levels in MANOLIS. across B100,000 individuals has also identified robust associations between a common-frequency variant (rs964184) 51.5 kb low-frequency variant associations in traits of medical relevance. with lipid traits by genome-wide association study (for example, A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates APOC3 variant associations with lipid traits APOC3 variant associations with lipid traits	./cache/work_3bwtv5c24nhuhmr5lwk5fbquu4.pdf	./txt/work_3bwtv5c24nhuhmr5lwk5fbquu4.txt