id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_c3uj7d3unjac3kqk7i3hfq7d74	Herbert M. Lachman	Linkage studies suggest a possible locus for bipolar disorder near the velo-cardio-facial syndrome region on chromosome 22	1997.0	8	.pdf	application/pdf	7367	633	62	Linkage Studies Suggest a Possible Locus for Bipolar Disorder Near the Velo-Cardio-Facial Syndrome Region on Chromosome 22 Twin, family, and adoption studies show that the vulnerability to develop bipolar disorder is inherited [Nurnberger et al., 1994; A recent genome-wide search also failed to provide convincing evidence for linkage to any chromosomal locus [Coon et al., 1993]. 1990] in conjunction with conventional lod score analysis, evidence was obtained for linkage to chromosomes 22q11 to determine whether linkage could be established in 17 multiplex families with bipolar disorder. Table IV summarizes the lod scores for each population and for the combined family set for the three markers used in the initial screen. In the combined families, only D22S303 yielded suggestive evidence of linkage in single-locus analyses (P 4 0.018). Published reports to date in which chromosome 22q markers have been examined in bipolar families indicate no evidence for linkage [Coon et al., 1993; chromosome 22q11 result in bipolar affective disorder.	./cache/work_c3uj7d3unjac3kqk7i3hfq7d74.pdf	./txt/work_c3uj7d3unjac3kqk7i3hfq7d74.txt