id author title date pages extension mime words sentences flesch summary cache txt work_eqe3d4ptn5eqbpekvtso5pmcce Evadnie Rampersaud Physical Activity and the Association of Common FTO Gene Variants With Body Mass Index and Obesity 2008.0 8 .pdf application/pdf 6687 1051 71 Physical Activity and the Association of Common FTO Gene Variants With Body Mass Index and Obesity that there is a substantial genetic contribution to body mass index (BMI), and recently, robust associations of common variants in intron 1 of the fat mass and obesity associated (FTO) gene with BMI, percentage of body fat, and obesity were identified in large studies of white adults and children.1-3 Owing to the high frequency of the detrimental associations of BMI-associated FTO gene variants can be lessened by increased physical activity. We accounted for the relatedness of OOA study subjects by estimating parameter effects conditional on residual correlations in BMI (or similar trait) between related individuals. We evaluated the associations of FTO SNPs on BMI after stratification of the sample according to "high" and "low" physical The presence of an interaction between physical activity and SNP genotype on BMI was assessed by a likelihood ratio test, in which we ./cache/work_eqe3d4ptn5eqbpekvtso5pmcce.pdf ./txt/work_eqe3d4ptn5eqbpekvtso5pmcce.txt