id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_ghjwb3wrkrfr3ddzqf3qytyeri	W.-C. Hsueh	A Genome-Wide Linkage Scan of Insulin Level Derived Traits: The Amish Family Diabetes Study	2007.0	6	.pdf	application/pdf	5153	427	62	RESEARCH DESIGN AND METHODS—We conducted a series of genetic analyses, including genome-wide and fine-mapping linkage studies, based on insulin levels measured during an oral glucose tolerance test (OGTT) in 552 nondiabetic participants in the Amish Family Diabetes Study. Fine-mapping study further refined our signal for insulin 30 on chromosome 15 (LOD 2.38 at 68 cM). CONCLUSIONS—These results suggest that there may be different genes influencing variation in OGTT measures of insulin Several studies have investigated the genetic epidemiology of fasting insulin levels and OGTT-derived indices traits may share common genetic influence, and performed genome-wide and fine-mapping linkage analyses of genetic influences underlying these OGTT-derived measures of insulin secretion and resistance. genome scan provides evidence of linkage on chromosomes 2p and 15q to measures of insulin secretion. genetic correlations were observed between fasting insulin and HOMA-IR, suggesting that these two measures LOD scores �1.18 (P � 0.01) for each insulin-related trait from multipoint linkage analyses	./cache/work_ghjwb3wrkrfr3ddzqf3qytyeri.pdf	./txt/work_ghjwb3wrkrfr3ddzqf3qytyeri.txt