id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_itmca66wvfdjlp7g64jlolrw7a	Tiffany A Greenwood	Promoter and intronic variants affect the transcriptional regulation of the human dopamine transporter gene	2003.0	10	.pdf	application/pdf	6997	517	58	We have attempted to identify regions involved in the transcriptional regulation of the DAT1 (HUGO approved symbol SLC6A3) gene haplotypes of the proximal promoter/intron 1 region, representing the two previously identified 5� clades. transcription with inclusion of the 9and 10-repeat alleles of the 3� VNTR, introns 9, 12, and 14 appear to contain enhancer elements capable Keywords: Dopamine transporter; Dopamine; Bipolar disorder; Genetic variation; Single-nucleotide polymorphism; Gene expression; Transcriptional region and intron 1 [2] and inserted upstream of the luciferase reporter gene to generate three constructs for each (A) Illustration of the haplotype structure of the 5� (promoter through intron 6) and 3� (exon 9 through exon 15) regions of the DAT1 gene, indicating the candidate genomic regions that may include sequence variants that contribute to functional variation in gene expression and possible susceptibility to human disease.	./cache/work_itmca66wvfdjlp7g64jlolrw7a.pdf	./txt/work_itmca66wvfdjlp7g64jlolrw7a.txt