id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_ji2irfeua5dynf322p3w2vgb6e	Masahiro Enomoto	Newborn rat response to single vs. combined cGMP-dependent pulmonary vasodilators	2014.0		.pdf	text/html	1337	226	59	Inhaled nitric oxide (NO) and other cGMPor cAMP-dependent pulmonary vasodilators are often used in combination for the treatment of the persistent pulmonary hypertension of the newborn syndrome. There is in vitro evidence to indicate that NO downregulate the pulmonary vascular response to cGMP-dependent agonists raising concern as to whether a synergistic effect is observed when employing a combined strategy in newborns. Soluble guanylate cyclase modulators blunt hyperoxia effects on calcium responses of developing human airway smooth muscle. Prolonged treatment of porcine pulmonary artery with nitric oxide decreases cGMP sensitivity and cGMP-dependent protein kinase specific activity. Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide. Reduction in soluble guanylyl cyclase-specific activity following prolonged treatment of porcine pulmonary artery with nitric oxide. Mechanisms of relaxant activity of the nitric oxide-independent soluble guanylyl cyclase stimulator BAY 41-2272 in rat tracheal smooth muscle.	./cache/work_ji2irfeua5dynf322p3w2vgb6e.pdf	./txt/work_ji2irfeua5dynf322p3w2vgb6e.txt