id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_simumtkwk5eizakjsswoju5xwq	C. Mirella Spalluto	IFN-γ Influences Epithelial Antiviral Responses via Histone Methylation of the RIG-I Promoter	2017.0	51	.pdf	application/pdf	11146	1206	65	subsequently infected cells with Respiratory Syncytial Virus (RSV) and innate anti-viral genes Priming epithelial cells with IFNγ reduced RSV viral load. Key Words: IFNγ, cytokine priming, RIG-I, epigenetic regulation of innate immune response, immune genes that may be responsible for the priming effect of IFNγ on the respiratory IFNγ upregulated the expression of RIG-I compared to both control cells and RSV A further increase in RIG-I expression by IFNγ-primed RSVinfected cells, was also observed and confirmed by RT-qPCR (FIGURE 3). data indicated a long term effect of IFNγ priming in PBECS and suggest epigenetic regulation differences in H3K9me3 were detected at the RIG-I promoter in IFNγ primed cells following 01294 to IFNγ primed cells led to a significant increase in RIG-I expression at both the RNA enhanced RIG-I mRNA expression following IFNγ priming correlated with epigenetic changes significant effects on RIG-I expression only in IFNγ primed cells. upregulate RIG-I expression when cells were also IFNγ primed.	./cache/work_simumtkwk5eizakjsswoju5xwq.pdf	./txt/work_simumtkwk5eizakjsswoju5xwq.txt