id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_sx6hxzgflbazfohbhxge6p7l64	Lu Q. Le	Overcoming BET inhibitor resistance in malignant peripheral nerve sheath tumors	2019.0	44	.pdf	application/pdf	12171	1141	55	levels of BRD4 for the investigation of emerging therapeutic interventions such as proteolysistargeting chimeras (PROTACs) that simultaneously target bromodomain activity and BET BRD4 protein levels synergistically sensitized MPNST cells to diverse BET inhibitors in culture BRD4 Levels Underlie Resistance to BET Inhibitor-Induced Death in MPNST Cells levels post-treatment can mediate resistance in BET inhibitor-treated MPNST cells. BRD4 Depletion Overcomes Resistance to BET Inhibitor-Induced Cell Death in MPNST. induced upon BRD4 inhibition by shRNA or small molecule BET inhibitors in MPNST cells Genetic Inhibition of BRD4 Overcomes MPNST Cell Resistance to Diverse BET Inhibitors These data suggest that BRD4-high cancer cells that display relative resistance to small synthetic lethality between Brd4 depletion and BET inhibitor treatment in MPNST. inhibitors in cell culture models of MPNST inhibition suggests some BRD4-high tumors may be BRD4 Depletion Overcomes Resistance to BET Inhibitor-Induced Cell Death in Genetic Inhibition of BRD4 Overcomes MPNST Cell Resistance to Diverse BET 	./cache/work_sx6hxzgflbazfohbhxge6p7l64.pdf	./txt/work_sx6hxzgflbazfohbhxge6p7l64.txt