id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_t32aq22hx5cpjaoanvx7bmjnoa	Mathew J. Wong	Simvastatin prevents and reverses chronic pulmonary hypertension in newborn rats via pleiotropic inhibition of RhoA signaling	2016.0	15	.pdf	application/pdf	11275	1038	58	Simvastatin prevents and reverses chronic pulmonary hypertension in newborn rats via pleiotropic inhibition of RhoA signaling Preventive or rescue treatment of chronic hypoxiaexposed animals with simvastatin decreased pulmonary vascular resistance, right ventricular hypertrophy, and pulmonary arterial remodeling. limits RhoA/ROCK activity in the chronic hypoxia-exposed lung, thus Hypoxia-exposed, vehicle-treated pups had significantly elevated RhoA activity in the lung relative to normoxia controls at hypoxia-exposed pups treated with simvastatin had significantly reduced GTP-RhoA content when given as either preventive or as rescue therapy (Figs. Lungs of hypoxia-exposed, vehicle-treated pups had significantly increased ROCK activity Simvastatin prevented chronic hypoxia-induced pulmonary hypertension. Simvastatin prevented chronic hypoxia-induced pulmonary arterial remodeling. Rescue treatment with simvastatin significantly increased distance run in females and males compared with hypoxia-exposed, vehicle-treated controls (Fig. 5E). Treatment with simvastatin decreased pulmonary HIF-1� levels in chronic hypoxiaexposed animals but did not affect lung content of RhoA or of	./cache/work_t32aq22hx5cpjaoanvx7bmjnoa.pdf	./txt/work_t32aq22hx5cpjaoanvx7bmjnoa.txt