id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_tqddavldsrhszcqpvak4judcla	Tom Cattaert	FAM-MDR: A Flexible Family-Based Multifactor Dimensionality Reduction Technique to Detect Epistasis Using Related Individuals	2010.0	15	.pdf	application/pdf	13449	1140	62	related individuals, FAM-MDR was found to outperform PGMDR in terms of power, in most of the considered simulated by gene-gene interactions, we applied FAM-MDR to examine data on glucose area-under-the-curve (GAUC), an endophenotype of T2DM for which multiple independent genetic associations have been observed, in the Amish Family This application reveals that FAM-MDR makes more efficient use of the available data than PGMDR PGMDR, the current state-of-the-art MDR method for family data, using both simulations and a practical dataset. application of FAM-MDR to determine epistasis in family studies FAM-MDR is an acronym for FAMily Multifactor Dimensionality Reduction and is an adaptation to related individuals of the simulated datasets for Model M27, p~0:25, g2~0:1 and h2~0:8, for the analysis without main effects correction. Without main effects correction, FAM-MDR on the original individuals are available for FAM-MDR without main effects Without correction for main effects, FAM-MDR on Without correction for main effects, FAM-MDR on	./cache/work_tqddavldsrhszcqpvak4judcla.pdf	./txt/work_tqddavldsrhszcqpvak4judcla.txt