id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_wmvyiwhfgvhixp2shq2ooqyhpe	Elizabeth K. Speliotes	Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits	2011.0	15	.pdf	application/pdf	14357	2668	72	http://osc.hul.harvard.edu/dash/open-access-feedback?handle=&title=Genome-Wide%20Association%20Analysis%20Identifies%20Variants%20Associated%20with%20Nonalcoholic%20Fatty%20Liver%20Disease%20That%20Have%20Distinct%20Effects%20on%20Metabolic%20Traits&community=1/4454685&collection=1/4454686&owningCollection1/4454686&harvardAuthors=dd1ca2f5051044d440807a8b6748069e&department Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk We sought to identify additional genetic variants influencing NAFLD using genome-wide association meta-analysis of genome-wide association (GWA) results between CT hepatic steatosis and ,2.4 million imputed or genotyped SNPs in 7,176 individuals from the Old Order Amish, Age, Gene/Environment Susceptibility-Reykjavik study (AGES), Family Heart, and Framingham Heart Studies, we identify variants associated at genome-wide significant levels resource development from the Framingham Heart Study investigators participating in the SNP Health Association Resource (SHARe) project. best associating loci were genotyped in histology based NAFLD samples (Stage 2) from the NASH CRN matched to genome wide genotyped and The effects of the five NAFLD associated SNPs on NASH CRN/iCONT, metabolic phenotypes and eQTLs in liver and adipose Direction of effect on CT fatty liver, histology NAFLD, lipid and glycemic traits of the best associating SNPs at the loci	./cache/work_wmvyiwhfgvhixp2shq2ooqyhpe.pdf	./txt/work_wmvyiwhfgvhixp2shq2ooqyhpe.txt