Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.3324/haematol.2018.196295 Corpus ID: 52269657Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study @article{Beers2019PrevalenceAM, title={Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study}, author={E. V. van Beers and Stephanie van Straaten and D. Morton and W. Barcellini and S. Eber and B. Glader and H. Yaish and S. Chonat and J. Kwiatkowski and Jennifer A Rothman and Mukta Sharma and E. Neufeld and S. Sheth and J. Despotovic and N. Kollmar and D. Posp{\'i}{\vs}ilov{\'a} and C. Knoll and K. Kuo and Y. Pastore and A. Thompson and P. E. Newburger and Y. Ravindranath and W. Wang and M. Wlodarski and H. Wang and S. Holzhauer and V. Breakey and M. Verhovsek and J. Kunz and Melissa M McNaull and M. Rose and Heather A. Bradeen and Kathryn Addonizio and A. Li and Hasan Al‐Sayegh and W. London and R. Grace}, journal={Haematologica}, year={2019}, volume={104}, pages={e51 - e53} } E. V. van Beers, Stephanie van Straaten, +34 authors R. Grace Published 2019 Medicine Haematologica Pyruvate kinase (PK) deficiency is the most common red cell glycolytic enzyme defect causing hereditary non-spherocytic hemolytic anemia. Current treatments are mainly supportive and include red cell transfusions and splenectomy.[1][1] Regular red cell transfusions are known to result in iron  View on FSF haematologica.org Save to Library Create Alert Cite Launch Research Feed Share This Paper 16 CitationsBackground Citations 2 View All Figures, Tables, and Topics from this paper table 1 figure 1 Iron Overload Deficiency of pyruvate kinase Lesch-Nyhan Syndrome Beer Paper Mentions Observational Patient Registry Clinical Trial Pyruvate Kinase Deficiency Natural History Study The purpose of this study is to describe the range and incidence of symptoms, treatments, and complications related to pyruvate kinase deficiency (PKD). Eligible patients are those of… Expand Conditions Congenital Non-Spherocytic Hemolytic Anemia, Pyruvate Kinase Deficiency Boston Children's Hospital December 2013 - May 2020 16 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency Comorbidities and complications in adults with pyruvate kinase deficiency A. Boscoe, Y. Yan, +14 authors R. Grace Medicine European journal of haematology 2020 Save Alert Research Feed Management of Pyruvate Kinase Deficiency in Children and Adults. R. Grace, W. Barcellini Medicine Blood 2020 1 Save Alert Research Feed How we manage patients with pyruvate kinase deficiency R. Grace, D. Mark Layton, W. Barcellini Medicine British journal of haematology 2019 20 Save Alert Research Feed Molecular heterogeneity of pyruvate kinase deficiency. P. Bianchi, E. Fermo Medicine Haematologica 2020 1 Save Alert Research Feed The variable manifestations of disease in pyruvate kinase deficiency and their management. H. Al-Samkari, E. V. van Beers, +7 authors R. Grace Medicine Haematologica 2020 4 Save Alert Research Feed A Family Affected by a Life-Threatening Erythrocyte Defect Caused by Pyruvate Kinase Deficiency With Normal Iron Status: A Case Report Karolina Maciak, A. Adamowicz-Salach, J. Poznański, M. Góra, J. Fronk, B. Burzynska Medicine Frontiers in Genetics 2020 View 2 excerpts, cites background Save Alert Research Feed Laboratory approach to investigation of anemia with a focus on pyruvate kinase deficiency A. Agarwal, Anton Rets Medicine International journal of laboratory hematology 2020 Save Alert Research Feed Development of the pyruvate kinase deficiency diary and pyruvate kinase deficiency impact assessment: Disease‐specific assessments S. Salek, A. Boscoe, +7 authors Michael Storm Medicine European journal of haematology 2019 Save Alert Research Feed Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency. R. Grace, C. Rose, +18 authors B. Glader Medicine The New England journal of medicine 2019 19 Save Alert Research Feed Iron overload in congenital haemolytic anaemias: role of hepcidin and cytokines and predictive value of ferritin and transferrin saturation W. Barcellini, A. Zaninoni, +10 authors M. Cappellini Medicine British journal of haematology 2019 3 Save Alert Research Feed ... 1 2 ... References SHOWING 1-8 OF 8 REFERENCES Erythrocyte pyruvate kinase deficiency: 2015 status report R. Grace, A. Zanella, +4 authors B. Glader Medicine American journal of hematology 2015 83 View 1 excerpt, references background Save Alert Research Feed Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study. R. Grace, P. Bianchi, +37 authors W. 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Noce Medicine The New England journal of medicine 2011 115 View 1 excerpt, references methods Save Alert Research Feed Related Papers Abstract Figures, Tables, and Topics Paper Mentions 16 Citations 8 References Related Papers Stay Connected With Semantic Scholar Sign Up About Semantic Scholar Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. Learn More → Resources DatasetsSupp.aiAPIOpen Corpus Organization About UsResearchPublishing PartnersData Partners   FAQContact Proudly built by AI2 with the help of our Collaborators Terms of Service•Privacy Policy The Allen Institute for AI By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License ACCEPT & CONTINUE