Rare Variant APOC3 R19X Is Associated With Cardio-Protective Profiles in a Diverse Population-Based Survey as Part of the Epidemiologic Architecture for Genes Linked to Environment Study | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1161/CIRCGENETICS.113.000369 Corpus ID: 8381474Rare Variant APOC3 R19X Is Associated With Cardio-Protective Profiles in a Diverse Population-Based Survey as Part of the Epidemiologic Architecture for Genes Linked to Environment Study @article{Crawford2014RareVA, title={Rare Variant APOC3 R19X Is Associated With Cardio-Protective Profiles in a Diverse Population-Based Survey as Part of the Epidemiologic Architecture for Genes Linked to Environment Study}, author={D. Crawford and L. Dumitrescu and R. Goodloe and K. Brown-Gentry and J. Boston and B. McClellan and Cara B. Sutcliffe and R. Wiseman and Paxton Baker and M. Pericak-Vance and W. Scott and M. Allen and Ping Mayo and N. Schnetz-Boutaud and H. Dilks and J. Haines and T. Pollin}, journal={Circulation: Cardiovascular Genetics}, year={2014}, volume={7}, pages={848–853} } D. Crawford, L. Dumitrescu, +14 authors T. Pollin Published 2014 Biology, Medicine Circulation: Cardiovascular Genetics Background—A founder mutation was recently discovered and described as conferring favorable lipid profiles and reduced subclinical atherosclerotic disease in a Pennsylvania Amish population. Preliminary data have suggested that this null mutation APOC3 R19X (rs76353203) is rare in the general population. Methods and Results—To better describe the frequency and lipid profile in the general population, we as part of the Population Architecture using Genomics and Epidemiology I Study and the… Expand View on Wolters Kluwer ahajournals.org Save to Library Create Alert Cite Launch Research Feed Share This Paper 23 CitationsBackground Citations 6 Results Citations 1 View All Tables and Topics from this paper table 1 table 2 table 3 Cholesterol Lipoproteins Triglycerides Gene Frequency Angina Pectoris, Variant 23 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency Frequency and phenotype consequence of APOC3 rare variants in patients with very low triglyceride levels D. Crawford, Nicole A. Restrepo, Kirsten E. Diggins, E. Farber-Eger, Q. Wells Medicine BMC Medical Genomics 2018 1 PDF View 11 excerpts, cites background and results Save Alert Research Feed Cryptic relatedness in epidemiologic collections accessed for genetic association studies: experiences from the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) study and the National Health and Nutrition Examination Surveys (NHANES) J. Malinowski, R. Goodloe, K. Brown-Gentry, D. Crawford Geography, Medicine Front. Genet. 2015 6 Save Alert Research Feed Finding Rare, Disease-Associated Variants in Isolated Groups: Potential Advantages of Mennonite Populations F. Lopes, L. Hou, +4 authors F. McMahon Biology, Medicine Human Biology 2016 3 View 1 excerpt, cites background Save Alert Research Feed Population Stratification in the Context of Diverse Epidemiologic Surveys Sans Genome-Wide Data M. Oetjens, K. Brown-Gentry, R. Goodloe, H. Dilks, D. Crawford Biology, Medicine Front. Genet. 2016 5 Save Alert Research Feed Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels Zhe Wang, Hai-kui Chen, +37 authors A. Morrison Biology, Medicine 2018 2 PDF Save Alert Research Feed Role of Rare and Low-Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels Zhe Wang, H. Chen, +37 authors A. Morrison Biology, Medicine Circulation. Genomic and precision medicine 2020 2 Save Alert Research Feed Genomics of hypertriglyceridemia. Hayato Tada, M. Takamura, M. Kawashiri Medicine Advances in clinical chemistry 2020 Save Alert Research Feed APOC3 Loss-of-Function Mutations, Remnant Cholesterol, Low-Density Lipoprotein Cholesterol, and Cardiovascular Risk: Mediation- and Meta-Analyses of 137 895 Individuals A. B. Wulff, B. Nordestgaard, A. 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