id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_aayck5zf6nbijjlev64fhl4u7q	Stephen J. O'Brien	A Beautiful Life: High Risk–High Payoff in Genetic Science	2019	27	.pdf	application/pdf	18185	4047	76	The fifth research emphasis outlines the population genetic–based search and discovery of human restriction genes that influence the epidemiological outcome evolutionary perspective provided by comparative genome sequencing of related species. specific CATS primers to amplify genomic sequences of available species across mammals to resolve the mammal phylogeny using the molecular clock. consideration of the genetic and genomic history of that species. After first consulting with human geneticists and AIDS experts and securing NCI financial support, we mounted a search for what we called AIDS-restriction genes, host genetic variants that genotype large numbers of individuals in the AIDS cohort studies with DNA variants in candidate genes (those genes implicated as important in AIDS pathogenesis) for HIV infection, AIDS genotyping for hundreds of gene candidates (Mary Carrington led the HLA and KIR typing effort), all in search of a statistically significant population genetic signal for AIDS influence. A biochemical genetic map of the Drosophila genome.	./cache/work_aayck5zf6nbijjlev64fhl4u7q.pdf	./txt/work_aayck5zf6nbijjlev64fhl4u7q.txt