id author title date pages extension mime words sentences flesch summary cache txt work_fxc4y6pflne3naur5uno53roqe Zarine R. Balsara Sleeping beauty: awakening urothelium from its slumber 2017 12 .pdf application/pdf 12929 1351 53 cells that mediate urothelial regeneration are discussed and evidence for each model urothelium; regeneration; progenitor cells; superficial cells; label retention; lineage either basal or intermediate cells, it is no surprise that histological analysis of whole-mount adult mouse bladders has only cell layer in the bladder to express the low-molecularweight cytokeratin 20 (Krt20) (29, 68, 82). Consistent with the quiescent nature of urothelium, the baseline proliferation of urothelial cells dramatically decreases and that urothelial stem cells express the transcription factor p63 Krt14� basal cells serves as the urothelial progenitors responsible for superficial cell regeneration both during normal homeostasis and after injury (77). urothelial cells also respond to local growth factors that promote regeneration and repair. regeneration and ingrowth of urothelial cells in bladder augmentation procedures (reviewed in Ref. 63). demonstrated that UPEC induces expression of Ezh2 in human bladder cancer cells (93). malignant urothelium, EGFR begins to be expressed throughout all urothelial cell layers, rather than remaining confined to ./cache/work_fxc4y6pflne3naur5uno53roqe.pdf ./txt/work_fxc4y6pflne3naur5uno53roqe.txt