id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_lt4ogaqnrnhw5aneteymdwxayy	György Abrusán	Structural Determinants of Sleeping Beauty Transposase Activity	2016	26	.pdf	application/pdf	7717	1027	69	functions of the transposase coevolve; 2) Sector residues are highly sensitive to mutations, with point energy of folding in the DDE domain of the transposase significantly reduce transposition rate. although most hyperactive mutants are also located on the protein surface, including residues with sectors are of similar importance in more complex multi-domain structures as in small proteins The dependence of transposition rate on sectors, protein core and conservation. structure have a large influence on their effect: mutations in protein sectors, conserved residues (D > 0.5, sectors, nor the protein core, and are also not conserved ("other" residues, Figure 3) indicates, that the domain G is correlated with transposition rates (Figure 4D), we tested whether the effect of sectors sector residues have a similar effect on transposition rate as mutations of conserved but non-sector sectors, conserved residues or protein core have increased transpositional activity. B) The effect of sectors, conserved residues and protein core on transposition rate (median, 	./cache/work_lt4ogaqnrnhw5aneteymdwxayy.pdf	./txt/work_lt4ogaqnrnhw5aneteymdwxayy.txt