id sid tid token lemma pos work_7k7caouvh5efzjp7ikemnmn54u 1 1 doi:10.1016 doi:10.1016 JJ work_7k7caouvh5efzjp7ikemnmn54u 1 2 / / SYM work_7k7caouvh5efzjp7ikemnmn54u 1 3 S1359 S1359 NNP work_7k7caouvh5efzjp7ikemnmn54u 1 4 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 1 5 0278(96)00027 0278(96)00027 NNP work_7k7caouvh5efzjp7ikemnmn54u 1 6 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 1 7 2 2 CD work_7k7caouvh5efzjp7ikemnmn54u 1 8 R50 R50 NNP work_7k7caouvh5efzjp7ikemnmn54u 1 9 Review Review NNP work_7k7caouvh5efzjp7ikemnmn54u 1 10 Modeling Modeling NNP work_7k7caouvh5efzjp7ikemnmn54u 1 11 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 1 12 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 1 13 : : : work_7k7caouvh5efzjp7ikemnmn54u 1 14 the the DT work_7k7caouvh5efzjp7ikemnmn54u 1 15 beauty beauty NN work_7k7caouvh5efzjp7ikemnmn54u 1 16 and and CC work_7k7caouvh5efzjp7ikemnmn54u 1 17 power power NN work_7k7caouvh5efzjp7ikemnmn54u 1 18 of of IN work_7k7caouvh5efzjp7ikemnmn54u 1 19 simplicity simplicity NN work_7k7caouvh5efzjp7ikemnmn54u 1 20 Eugene Eugene NNP work_7k7caouvh5efzjp7ikemnmn54u 1 21 I I NNP work_7k7caouvh5efzjp7ikemnmn54u 1 22 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 1 23 It -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 1 24 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 1 25 argued argue VBN work_7k7caouvh5efzjp7ikemnmn54u 1 26 that that IN work_7k7caouvh5efzjp7ikemnmn54u 1 27 simplified simplify VBN work_7k7caouvh5efzjp7ikemnmn54u 1 28 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 1 29 capture capture VBP work_7k7caouvh5efzjp7ikemnmn54u 1 30 key key JJ work_7k7caouvh5efzjp7ikemnmn54u 1 31 features feature NNS work_7k7caouvh5efzjp7ikemnmn54u 1 32 of of IN work_7k7caouvh5efzjp7ikemnmn54u 1 33 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 1 34 stability stability NN work_7k7caouvh5efzjp7ikemnmn54u 1 35 and and CC work_7k7caouvh5efzjp7ikemnmn54u 1 36 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 1 37 , , , work_7k7caouvh5efzjp7ikemnmn54u 1 38 whereas whereas IN work_7k7caouvh5efzjp7ikemnmn54u 1 39 more more RBR work_7k7caouvh5efzjp7ikemnmn54u 1 40 detailed detailed JJ work_7k7caouvh5efzjp7ikemnmn54u 1 41 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 1 42 may may MD work_7k7caouvh5efzjp7ikemnmn54u 1 43 be be VB work_7k7caouvh5efzjp7ikemnmn54u 1 44 more more RBR work_7k7caouvh5efzjp7ikemnmn54u 1 45 appropriate appropriate JJ work_7k7caouvh5efzjp7ikemnmn54u 1 46 for for IN work_7k7caouvh5efzjp7ikemnmn54u 1 47 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 1 48 structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 1 49 prediction prediction NN work_7k7caouvh5efzjp7ikemnmn54u 1 50 . . . work_7k7caouvh5efzjp7ikemnmn54u 2 1 A a DT work_7k7caouvh5efzjp7ikemnmn54u 2 2 brief brief JJ work_7k7caouvh5efzjp7ikemnmn54u 2 3 overview overview NN work_7k7caouvh5efzjp7ikemnmn54u 2 4 of of IN work_7k7caouvh5efzjp7ikemnmn54u 2 5 experimental experimental JJ work_7k7caouvh5efzjp7ikemnmn54u 2 6 and and CC work_7k7caouvh5efzjp7ikemnmn54u 2 7 theoretical theoretical JJ work_7k7caouvh5efzjp7ikemnmn54u 2 8 results result NNS work_7k7caouvh5efzjp7ikemnmn54u 2 9 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 2 10 presented present VBN work_7k7caouvh5efzjp7ikemnmn54u 2 11 that that WDT work_7k7caouvh5efzjp7ikemnmn54u 2 12 corroborates corroborate VBZ work_7k7caouvh5efzjp7ikemnmn54u 2 13 these these DT work_7k7caouvh5efzjp7ikemnmn54u 2 14 points point NNS work_7k7caouvh5efzjp7ikemnmn54u 2 15 . . . work_7k7caouvh5efzjp7ikemnmn54u 3 1 I -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 3 2 argue argue VBP work_7k7caouvh5efzjp7ikemnmn54u 3 3 that that IN work_7k7caouvh5efzjp7ikemnmn54u 3 4 statistical statistical JJ work_7k7caouvh5efzjp7ikemnmn54u 3 5 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 3 6 capture capture VBP work_7k7caouvh5efzjp7ikemnmn54u 3 7 the the DT work_7k7caouvh5efzjp7ikemnmn54u 3 8 key key JJ work_7k7caouvh5efzjp7ikemnmn54u 3 9 principle principle NN work_7k7caouvh5efzjp7ikemnmn54u 3 10 of of IN work_7k7caouvh5efzjp7ikemnmn54u 3 11 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 3 12 stability stability NN work_7k7caouvh5efzjp7ikemnmn54u 3 13 — — : work_7k7caouvh5efzjp7ikemnmn54u 3 14 cooperativity cooperativity NN work_7k7caouvh5efzjp7ikemnmn54u 3 15 — — : work_7k7caouvh5efzjp7ikemnmn54u 3 16 and and CC work_7k7caouvh5efzjp7ikemnmn54u 3 17 therefore therefore RB work_7k7caouvh5efzjp7ikemnmn54u 3 18 provide provide VB work_7k7caouvh5efzjp7ikemnmn54u 3 19 a a DT work_7k7caouvh5efzjp7ikemnmn54u 3 20 reasonable reasonable JJ work_7k7caouvh5efzjp7ikemnmn54u 3 21 estimate estimate NN work_7k7caouvh5efzjp7ikemnmn54u 3 22 of of IN work_7k7caouvh5efzjp7ikemnmn54u 3 23 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 3 24 free free JJ work_7k7caouvh5efzjp7ikemnmn54u 3 25 energy energy NN work_7k7caouvh5efzjp7ikemnmn54u 3 26 whereas whereas IN work_7k7caouvh5efzjp7ikemnmn54u 3 27 more more RBR work_7k7caouvh5efzjp7ikemnmn54u 3 28 detailed detailed JJ work_7k7caouvh5efzjp7ikemnmn54u 3 29 but but CC work_7k7caouvh5efzjp7ikemnmn54u 3 30 less less RBR work_7k7caouvh5efzjp7ikemnmn54u 3 31 physically physically RB work_7k7caouvh5efzjp7ikemnmn54u 3 32 transparent transparent JJ work_7k7caouvh5efzjp7ikemnmn54u 3 33 calculations calculation NNS work_7k7caouvh5efzjp7ikemnmn54u 3 34 fail fail VBP work_7k7caouvh5efzjp7ikemnmn54u 3 35 to to TO work_7k7caouvh5efzjp7ikemnmn54u 3 36 do do VB work_7k7caouvh5efzjp7ikemnmn54u 3 37 so so RB work_7k7caouvh5efzjp7ikemnmn54u 3 38 . . . work_7k7caouvh5efzjp7ikemnmn54u 4 1 I -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 4 2 also also RB work_7k7caouvh5efzjp7ikemnmn54u 4 3 explain explain VBP work_7k7caouvh5efzjp7ikemnmn54u 4 4 that that IN work_7k7caouvh5efzjp7ikemnmn54u 4 5 the the DT work_7k7caouvh5efzjp7ikemnmn54u 4 6 previously previously RB work_7k7caouvh5efzjp7ikemnmn54u 4 7 published publish VBN work_7k7caouvh5efzjp7ikemnmn54u 4 8 claim claim NN work_7k7caouvh5efzjp7ikemnmn54u 4 9 that that IN work_7k7caouvh5efzjp7ikemnmn54u 4 10 simple simple JJ work_7k7caouvh5efzjp7ikemnmn54u 4 11 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 4 12 give give VBP work_7k7caouvh5efzjp7ikemnmn54u 4 13 predictions prediction NNS work_7k7caouvh5efzjp7ikemnmn54u 4 14 that that WDT work_7k7caouvh5efzjp7ikemnmn54u 4 15 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 4 16 inconsistent inconsistent JJ work_7k7caouvh5efzjp7ikemnmn54u 4 17 with with IN work_7k7caouvh5efzjp7ikemnmn54u 4 18 experiments experiment NNS work_7k7caouvh5efzjp7ikemnmn54u 4 19 on on IN work_7k7caouvh5efzjp7ikemnmn54u 4 20 polypeptide polypeptide NN work_7k7caouvh5efzjp7ikemnmn54u 4 21 block block NN work_7k7caouvh5efzjp7ikemnmn54u 4 22 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 4 23 copolymers copolymer NNS work_7k7caouvh5efzjp7ikemnmn54u 4 24 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 4 25 based base VBN work_7k7caouvh5efzjp7ikemnmn54u 4 26 on on IN work_7k7caouvh5efzjp7ikemnmn54u 4 27 incomplete incomplete JJ work_7k7caouvh5efzjp7ikemnmn54u 4 28 analysis analysis NN work_7k7caouvh5efzjp7ikemnmn54u 4 29 of of IN work_7k7caouvh5efzjp7ikemnmn54u 4 30 such such JJ work_7k7caouvh5efzjp7ikemnmn54u 4 31 experiments experiment NNS work_7k7caouvh5efzjp7ikemnmn54u 4 32 . . . work_7k7caouvh5efzjp7ikemnmn54u 5 1 Address address NN work_7k7caouvh5efzjp7ikemnmn54u 5 2 : : : work_7k7caouvh5efzjp7ikemnmn54u 5 3 Department Department NNP work_7k7caouvh5efzjp7ikemnmn54u 5 4 of of IN work_7k7caouvh5efzjp7ikemnmn54u 5 5 Chemistry Chemistry NNP work_7k7caouvh5efzjp7ikemnmn54u 5 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 5 7 Harvard Harvard NNP work_7k7caouvh5efzjp7ikemnmn54u 5 8 University University NNP work_7k7caouvh5efzjp7ikemnmn54u 5 9 , , , work_7k7caouvh5efzjp7ikemnmn54u 5 10 12 12 CD work_7k7caouvh5efzjp7ikemnmn54u 5 11 Oxford Oxford NNP work_7k7caouvh5efzjp7ikemnmn54u 5 12 Street Street NNP work_7k7caouvh5efzjp7ikemnmn54u 5 13 , , , work_7k7caouvh5efzjp7ikemnmn54u 5 14 Cambridge Cambridge NNP work_7k7caouvh5efzjp7ikemnmn54u 5 15 , , , work_7k7caouvh5efzjp7ikemnmn54u 5 16 MA MA NNP work_7k7caouvh5efzjp7ikemnmn54u 5 17 02138 02138 CD work_7k7caouvh5efzjp7ikemnmn54u 5 18 , , , work_7k7caouvh5efzjp7ikemnmn54u 5 19 USA USA NNP work_7k7caouvh5efzjp7ikemnmn54u 5 20 . . . work_7k7caouvh5efzjp7ikemnmn54u 6 1 e e LS work_7k7caouvh5efzjp7ikemnmn54u 6 2 - - NN work_7k7caouvh5efzjp7ikemnmn54u 6 3 mail mail NN work_7k7caouvh5efzjp7ikemnmn54u 6 4 : : : work_7k7caouvh5efzjp7ikemnmn54u 6 5 eugene@diamond.harvard.edu eugene@diamond.harvard.edu ADD work_7k7caouvh5efzjp7ikemnmn54u 6 6 Electronic electronic JJ work_7k7caouvh5efzjp7ikemnmn54u 6 7 identifier identifier NN work_7k7caouvh5efzjp7ikemnmn54u 6 8 : : : work_7k7caouvh5efzjp7ikemnmn54u 6 9 1359 1359 CD work_7k7caouvh5efzjp7ikemnmn54u 6 10 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 6 11 0278 0278 CD work_7k7caouvh5efzjp7ikemnmn54u 6 12 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 6 13 001-R0050 001-R0050 NNP work_7k7caouvh5efzjp7ikemnmn54u 6 14 Folding Folding NNP work_7k7caouvh5efzjp7ikemnmn54u 6 15 & & CC work_7k7caouvh5efzjp7ikemnmn54u 6 16 Design Design NNP work_7k7caouvh5efzjp7ikemnmn54u 6 17 01 01 CD work_7k7caouvh5efzjp7ikemnmn54u 6 18 June June NNP work_7k7caouvh5efzjp7ikemnmn54u 6 19 1996 1996 CD work_7k7caouvh5efzjp7ikemnmn54u 6 20 , , , work_7k7caouvh5efzjp7ikemnmn54u 6 21 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 6 22 : : : work_7k7caouvh5efzjp7ikemnmn54u 6 23 R50–R54 R50–R54 NNP work_7k7caouvh5efzjp7ikemnmn54u 6 24 © © NNP work_7k7caouvh5efzjp7ikemnmn54u 6 25 Current Current NNP work_7k7caouvh5efzjp7ikemnmn54u 6 26 Biology Biology NNP work_7k7caouvh5efzjp7ikemnmn54u 6 27 Ltd Ltd NNP work_7k7caouvh5efzjp7ikemnmn54u 6 28 ISSN ISSN NNP work_7k7caouvh5efzjp7ikemnmn54u 6 29 1359 1359 CD work_7k7caouvh5efzjp7ikemnmn54u 6 30 - - SYM work_7k7caouvh5efzjp7ikemnmn54u 6 31 0278 0278 CD work_7k7caouvh5efzjp7ikemnmn54u 6 32 The the DT work_7k7caouvh5efzjp7ikemnmn54u 6 33 recent recent JJ work_7k7caouvh5efzjp7ikemnmn54u 6 34 commentary commentary NN work_7k7caouvh5efzjp7ikemnmn54u 6 35 by by IN work_7k7caouvh5efzjp7ikemnmn54u 6 36 Honig Honig NNP work_7k7caouvh5efzjp7ikemnmn54u 6 37 and and CC work_7k7caouvh5efzjp7ikemnmn54u 6 38 Cohen Cohen NNP work_7k7caouvh5efzjp7ikemnmn54u 6 39 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 6 40 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 6 41 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 6 42 in in IN work_7k7caouvh5efzjp7ikemnmn54u 6 43 Folding Folding NNP work_7k7caouvh5efzjp7ikemnmn54u 6 44 & & CC work_7k7caouvh5efzjp7ikemnmn54u 6 45 Design Design NNP work_7k7caouvh5efzjp7ikemnmn54u 6 46 discusses discuss VBZ work_7k7caouvh5efzjp7ikemnmn54u 6 47 the the DT work_7k7caouvh5efzjp7ikemnmn54u 6 48 role role NN work_7k7caouvh5efzjp7ikemnmn54u 6 49 of of IN work_7k7caouvh5efzjp7ikemnmn54u 6 50 different different JJ work_7k7caouvh5efzjp7ikemnmn54u 6 51 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 6 52 in in IN work_7k7caouvh5efzjp7ikemnmn54u 6 53 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 6 54 studies study NNS work_7k7caouvh5efzjp7ikemnmn54u 6 55 . . . work_7k7caouvh5efzjp7ikemnmn54u 7 1 Such such JJ work_7k7caouvh5efzjp7ikemnmn54u 7 2 discussion discussion NN work_7k7caouvh5efzjp7ikemnmn54u 7 3 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 7 4 timely timely JJ work_7k7caouvh5efzjp7ikemnmn54u 7 5 , , , work_7k7caouvh5efzjp7ikemnmn54u 7 6 because because IN work_7k7caouvh5efzjp7ikemnmn54u 7 7 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 7 8 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 7 9 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 7 10 a a DT work_7k7caouvh5efzjp7ikemnmn54u 7 11 fascinating fascinating JJ work_7k7caouvh5efzjp7ikemnmn54u 7 12 cross cross JJ work_7k7caouvh5efzjp7ikemnmn54u 7 13 - - JJ work_7k7caouvh5efzjp7ikemnmn54u 7 14 disciplinary disciplinary JJ work_7k7caouvh5efzjp7ikemnmn54u 7 15 field field NN work_7k7caouvh5efzjp7ikemnmn54u 7 16 that that WDT work_7k7caouvh5efzjp7ikemnmn54u 7 17 attracts attract VBZ work_7k7caouvh5efzjp7ikemnmn54u 7 18 scientists scientist NNS work_7k7caouvh5efzjp7ikemnmn54u 7 19 with with IN work_7k7caouvh5efzjp7ikemnmn54u 7 20 different different JJ work_7k7caouvh5efzjp7ikemnmn54u 7 21 background background NN work_7k7caouvh5efzjp7ikemnmn54u 7 22 and and CC work_7k7caouvh5efzjp7ikemnmn54u 7 23 scientific scientific JJ work_7k7caouvh5efzjp7ikemnmn54u 7 24 cul- cul- NN work_7k7caouvh5efzjp7ikemnmn54u 7 25 tures ture NNS work_7k7caouvh5efzjp7ikemnmn54u 7 26 . . . work_7k7caouvh5efzjp7ikemnmn54u 8 1 They -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 8 2 bring bring VBP work_7k7caouvh5efzjp7ikemnmn54u 8 3 to to IN work_7k7caouvh5efzjp7ikemnmn54u 8 4 the the DT work_7k7caouvh5efzjp7ikemnmn54u 8 5 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 8 6 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 8 7 field field NN work_7k7caouvh5efzjp7ikemnmn54u 8 8 the the DT work_7k7caouvh5efzjp7ikemnmn54u 8 9 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 8 10 and and CC work_7k7caouvh5efzjp7ikemnmn54u 8 11 ways way NNS work_7k7caouvh5efzjp7ikemnmn54u 8 12 of of IN work_7k7caouvh5efzjp7ikemnmn54u 8 13 thinking thinking NN work_7k7caouvh5efzjp7ikemnmn54u 8 14 that that WDT work_7k7caouvh5efzjp7ikemnmn54u 8 15 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 8 16 accepted accept VBN work_7k7caouvh5efzjp7ikemnmn54u 8 17 in in IN work_7k7caouvh5efzjp7ikemnmn54u 8 18 their -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 8 19 respective respective JJ work_7k7caouvh5efzjp7ikemnmn54u 8 20 background background NN work_7k7caouvh5efzjp7ikemnmn54u 8 21 fields field NNS work_7k7caouvh5efzjp7ikemnmn54u 8 22 . . . work_7k7caouvh5efzjp7ikemnmn54u 9 1 Such such JJ work_7k7caouvh5efzjp7ikemnmn54u 9 2 diversity diversity NN work_7k7caouvh5efzjp7ikemnmn54u 9 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 9 4 scientific scientific JJ work_7k7caouvh5efzjp7ikemnmn54u 9 5 cultures culture NNS work_7k7caouvh5efzjp7ikemnmn54u 9 6 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 9 7 a a DT work_7k7caouvh5efzjp7ikemnmn54u 9 8 great great JJ work_7k7caouvh5efzjp7ikemnmn54u 9 9 virtue virtue NN work_7k7caouvh5efzjp7ikemnmn54u 9 10 of of IN work_7k7caouvh5efzjp7ikemnmn54u 9 11 the the DT work_7k7caouvh5efzjp7ikemnmn54u 9 12 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 9 13 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 9 14 field field NN work_7k7caouvh5efzjp7ikemnmn54u 9 15 , , , work_7k7caouvh5efzjp7ikemnmn54u 9 16 in in IN work_7k7caouvh5efzjp7ikemnmn54u 9 17 which which WDT work_7k7caouvh5efzjp7ikemnmn54u 9 18 physics physics NN work_7k7caouvh5efzjp7ikemnmn54u 9 19 , , , work_7k7caouvh5efzjp7ikemnmn54u 9 20 chemistry chemistry NN work_7k7caouvh5efzjp7ikemnmn54u 9 21 , , , work_7k7caouvh5efzjp7ikemnmn54u 9 22 biology biology NN work_7k7caouvh5efzjp7ikemnmn54u 9 23 and and CC work_7k7caouvh5efzjp7ikemnmn54u 9 24 mathematics mathematic NNS work_7k7caouvh5efzjp7ikemnmn54u 9 25 meet meet VBP work_7k7caouvh5efzjp7ikemnmn54u 9 26 . . . work_7k7caouvh5efzjp7ikemnmn54u 10 1 It -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 10 2 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 10 3 important important JJ work_7k7caouvh5efzjp7ikemnmn54u 10 4 for for IN work_7k7caouvh5efzjp7ikemnmn54u 10 5 our -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 10 6 cross cross JJ work_7k7caouvh5efzjp7ikemnmn54u 10 7 - - JJ work_7k7caouvh5efzjp7ikemnmn54u 10 8 disciplinary disciplinary JJ work_7k7caouvh5efzjp7ikemnmn54u 10 9 field field NN work_7k7caouvh5efzjp7ikemnmn54u 10 10 to to TO work_7k7caouvh5efzjp7ikemnmn54u 10 11 discuss discuss VB work_7k7caouvh5efzjp7ikemnmn54u 10 12 with with IN work_7k7caouvh5efzjp7ikemnmn54u 10 13 balance balance NN work_7k7caouvh5efzjp7ikemnmn54u 10 14 both both DT work_7k7caouvh5efzjp7ikemnmn54u 10 15 strong strong JJ work_7k7caouvh5efzjp7ikemnmn54u 10 16 points point NNS work_7k7caouvh5efzjp7ikemnmn54u 10 17 and and CC work_7k7caouvh5efzjp7ikemnmn54u 10 18 limitations limitation NNS work_7k7caouvh5efzjp7ikemnmn54u 10 19 of of IN work_7k7caouvh5efzjp7ikemnmn54u 10 20 different different JJ work_7k7caouvh5efzjp7ikemnmn54u 10 21 approaches approach NNS work_7k7caouvh5efzjp7ikemnmn54u 10 22 . . . work_7k7caouvh5efzjp7ikemnmn54u 11 1 To to IN work_7k7caouvh5efzjp7ikemnmn54u 11 2 this this DT work_7k7caouvh5efzjp7ikemnmn54u 11 3 end end NN work_7k7caouvh5efzjp7ikemnmn54u 11 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 11 5 the the DT work_7k7caouvh5efzjp7ikemnmn54u 11 6 article article NN work_7k7caouvh5efzjp7ikemnmn54u 11 7 by by IN work_7k7caouvh5efzjp7ikemnmn54u 11 8 Honig Honig NNP work_7k7caouvh5efzjp7ikemnmn54u 11 9 and and CC work_7k7caouvh5efzjp7ikemnmn54u 11 10 Cohen Cohen NNP work_7k7caouvh5efzjp7ikemnmn54u 11 11 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 11 12 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 11 13 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 11 14 can can MD work_7k7caouvh5efzjp7ikemnmn54u 11 15 be be VB work_7k7caouvh5efzjp7ikemnmn54u 11 16 seen see VBN work_7k7caouvh5efzjp7ikemnmn54u 11 17 as as IN work_7k7caouvh5efzjp7ikemnmn54u 11 18 a a DT work_7k7caouvh5efzjp7ikemnmn54u 11 19 ‘ ' `` work_7k7caouvh5efzjp7ikemnmn54u 11 20 nucleus nucleus NN work_7k7caouvh5efzjp7ikemnmn54u 11 21 ’ ' '' work_7k7caouvh5efzjp7ikemnmn54u 11 22 for for IN work_7k7caouvh5efzjp7ikemnmn54u 11 23 such such PDT work_7k7caouvh5efzjp7ikemnmn54u 11 24 a a DT work_7k7caouvh5efzjp7ikemnmn54u 11 25 discussion discussion NN work_7k7caouvh5efzjp7ikemnmn54u 11 26 in in IN work_7k7caouvh5efzjp7ikemnmn54u 11 27 Folding Folding NNP work_7k7caouvh5efzjp7ikemnmn54u 11 28 & & CC work_7k7caouvh5efzjp7ikemnmn54u 11 29 Design Design NNP work_7k7caouvh5efzjp7ikemnmn54u 11 30 both both DT work_7k7caouvh5efzjp7ikemnmn54u 11 31 on on IN work_7k7caouvh5efzjp7ikemnmn54u 11 32 paper paper NN work_7k7caouvh5efzjp7ikemnmn54u 11 33 and and CC work_7k7caouvh5efzjp7ikemnmn54u 11 34 on on IN work_7k7caouvh5efzjp7ikemnmn54u 11 35 the the DT work_7k7caouvh5efzjp7ikemnmn54u 11 36 internet internet NN work_7k7caouvh5efzjp7ikemnmn54u 11 37 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 11 38 see see VB work_7k7caouvh5efzjp7ikemnmn54u 11 39 the the DT work_7k7caouvh5efzjp7ikemnmn54u 11 40 discussion discussion NN work_7k7caouvh5efzjp7ikemnmn54u 11 41 pages page NNS work_7k7caouvh5efzjp7ikemnmn54u 11 42 on on IN work_7k7caouvh5efzjp7ikemnmn54u 11 43 BioMedNet BioMedNet NNP work_7k7caouvh5efzjp7ikemnmn54u 11 44 at at IN work_7k7caouvh5efzjp7ikemnmn54u 11 45 http://BioMedNet.com/ http://BioMedNet.com/ NNP work_7k7caouvh5efzjp7ikemnmn54u 11 46 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 11 47 . . . work_7k7caouvh5efzjp7ikemnmn54u 12 1 Unfor- Unfor- NNP work_7k7caouvh5efzjp7ikemnmn54u 12 2 tunately tunately RB work_7k7caouvh5efzjp7ikemnmn54u 12 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 12 4 as as IN work_7k7caouvh5efzjp7ikemnmn54u 12 5 happens happen VBZ work_7k7caouvh5efzjp7ikemnmn54u 12 6 in in IN work_7k7caouvh5efzjp7ikemnmn54u 12 7 many many JJ work_7k7caouvh5efzjp7ikemnmn54u 12 8 discussions discussion NNS work_7k7caouvh5efzjp7ikemnmn54u 12 9 , , , work_7k7caouvh5efzjp7ikemnmn54u 12 10 the the DT work_7k7caouvh5efzjp7ikemnmn54u 12 11 commentary commentary NN work_7k7caouvh5efzjp7ikemnmn54u 12 12 presents present VBZ work_7k7caouvh5efzjp7ikemnmn54u 12 13 somewhat somewhat RB work_7k7caouvh5efzjp7ikemnmn54u 12 14 extreme extreme JJ work_7k7caouvh5efzjp7ikemnmn54u 12 15 views view NNS work_7k7caouvh5efzjp7ikemnmn54u 12 16 , , , work_7k7caouvh5efzjp7ikemnmn54u 12 17 minimizing minimize VBG work_7k7caouvh5efzjp7ikemnmn54u 12 18 the the DT work_7k7caouvh5efzjp7ikemnmn54u 12 19 value value NN work_7k7caouvh5efzjp7ikemnmn54u 12 20 of of IN work_7k7caouvh5efzjp7ikemnmn54u 12 21 approaches approach NNS work_7k7caouvh5efzjp7ikemnmn54u 12 22 based base VBN work_7k7caouvh5efzjp7ikemnmn54u 12 23 on on IN work_7k7caouvh5efzjp7ikemnmn54u 12 24 simplified simplified JJ work_7k7caouvh5efzjp7ikemnmn54u 12 25 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 12 26 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 12 27 . . . work_7k7caouvh5efzjp7ikemnmn54u 13 1 Such such PDT work_7k7caouvh5efzjp7ikemnmn54u 13 2 an an DT work_7k7caouvh5efzjp7ikemnmn54u 13 3 assessment assessment NN work_7k7caouvh5efzjp7ikemnmn54u 13 4 does do VBZ work_7k7caouvh5efzjp7ikemnmn54u 13 5 not not RB work_7k7caouvh5efzjp7ikemnmn54u 13 6 seem seem VB work_7k7caouvh5efzjp7ikemnmn54u 13 7 to to TO work_7k7caouvh5efzjp7ikemnmn54u 13 8 be be VB work_7k7caouvh5efzjp7ikemnmn54u 13 9 substantiated substantiate VBN work_7k7caouvh5efzjp7ikemnmn54u 13 10 by by IN work_7k7caouvh5efzjp7ikemnmn54u 13 11 facts fact NNS work_7k7caouvh5efzjp7ikemnmn54u 13 12 and and CC work_7k7caouvh5efzjp7ikemnmn54u 13 13 by by IN work_7k7caouvh5efzjp7ikemnmn54u 13 14 consistent consistent JJ work_7k7caouvh5efzjp7ikemnmn54u 13 15 analysis analysis NN work_7k7caouvh5efzjp7ikemnmn54u 13 16 of of IN work_7k7caouvh5efzjp7ikemnmn54u 13 17 recent recent JJ work_7k7caouvh5efzjp7ikemnmn54u 13 18 developments development NNS work_7k7caouvh5efzjp7ikemnmn54u 13 19 . . . work_7k7caouvh5efzjp7ikemnmn54u 14 1 The the DT work_7k7caouvh5efzjp7ikemnmn54u 14 2 purpose purpose NN work_7k7caouvh5efzjp7ikemnmn54u 14 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 14 4 my -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 14 5 response response NN work_7k7caouvh5efzjp7ikemnmn54u 14 6 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 14 7 to to TO work_7k7caouvh5efzjp7ikemnmn54u 14 8 present present VB work_7k7caouvh5efzjp7ikemnmn54u 14 9 an an DT work_7k7caouvh5efzjp7ikemnmn54u 14 10 alternative alternative JJ work_7k7caouvh5efzjp7ikemnmn54u 14 11 view- view- JJ work_7k7caouvh5efzjp7ikemnmn54u 14 12 point point NN work_7k7caouvh5efzjp7ikemnmn54u 14 13 based base VBN work_7k7caouvh5efzjp7ikemnmn54u 14 14 on on IN work_7k7caouvh5efzjp7ikemnmn54u 14 15 experimental experimental JJ work_7k7caouvh5efzjp7ikemnmn54u 14 16 facts fact NNS work_7k7caouvh5efzjp7ikemnmn54u 14 17 and and CC work_7k7caouvh5efzjp7ikemnmn54u 14 18 theoretical theoretical JJ work_7k7caouvh5efzjp7ikemnmn54u 14 19 analyses analysis NNS work_7k7caouvh5efzjp7ikemnmn54u 14 20 which which WDT work_7k7caouvh5efzjp7ikemnmn54u 14 21 show show VBP work_7k7caouvh5efzjp7ikemnmn54u 14 22 that that IN work_7k7caouvh5efzjp7ikemnmn54u 14 23 simplified simplify VBN work_7k7caouvh5efzjp7ikemnmn54u 14 24 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 14 25 have have VBP work_7k7caouvh5efzjp7ikemnmn54u 14 26 been be VBN work_7k7caouvh5efzjp7ikemnmn54u 14 27 a a DT work_7k7caouvh5efzjp7ikemnmn54u 14 28 valuable valuable JJ work_7k7caouvh5efzjp7ikemnmn54u 14 29 tool tool NN work_7k7caouvh5efzjp7ikemnmn54u 14 30 for for IN work_7k7caouvh5efzjp7ikemnmn54u 14 31 the the DT work_7k7caouvh5efzjp7ikemnmn54u 14 32 study study NN work_7k7caouvh5efzjp7ikemnmn54u 14 33 of of IN work_7k7caouvh5efzjp7ikemnmn54u 14 34 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 14 35 . . . work_7k7caouvh5efzjp7ikemnmn54u 15 1 It -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 15 2 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 15 3 my -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 15 4 hope hope NN work_7k7caouvh5efzjp7ikemnmn54u 15 5 that that IN work_7k7caouvh5efzjp7ikemnmn54u 15 6 this this DT work_7k7caouvh5efzjp7ikemnmn54u 15 7 response response NN work_7k7caouvh5efzjp7ikemnmn54u 15 8 will will MD work_7k7caouvh5efzjp7ikemnmn54u 15 9 present present VB work_7k7caouvh5efzjp7ikemnmn54u 15 10 an an DT work_7k7caouvh5efzjp7ikemnmn54u 15 11 account account NN work_7k7caouvh5efzjp7ikemnmn54u 15 12 of of IN work_7k7caouvh5efzjp7ikemnmn54u 15 13 successes success NNS work_7k7caouvh5efzjp7ikemnmn54u 15 14 and and CC work_7k7caouvh5efzjp7ikemnmn54u 15 15 limita- limita- JJ work_7k7caouvh5efzjp7ikemnmn54u 15 16 tions tion NNS work_7k7caouvh5efzjp7ikemnmn54u 15 17 of of IN work_7k7caouvh5efzjp7ikemnmn54u 15 18 simplified simplify VBN work_7k7caouvh5efzjp7ikemnmn54u 15 19 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 15 20 that that WDT work_7k7caouvh5efzjp7ikemnmn54u 15 21 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 15 22 more more RBR work_7k7caouvh5efzjp7ikemnmn54u 15 23 balanced balanced JJ work_7k7caouvh5efzjp7ikemnmn54u 15 24 and and CC work_7k7caouvh5efzjp7ikemnmn54u 15 25 respectful respectful JJ work_7k7caouvh5efzjp7ikemnmn54u 15 26 to to IN work_7k7caouvh5efzjp7ikemnmn54u 15 27 all all DT work_7k7caouvh5efzjp7ikemnmn54u 15 28 points point NNS work_7k7caouvh5efzjp7ikemnmn54u 15 29 of of IN work_7k7caouvh5efzjp7ikemnmn54u 15 30 view view NN work_7k7caouvh5efzjp7ikemnmn54u 15 31 . . . work_7k7caouvh5efzjp7ikemnmn54u 16 1 It -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 16 2 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 16 3 obvious obvious JJ work_7k7caouvh5efzjp7ikemnmn54u 16 4 that that IN work_7k7caouvh5efzjp7ikemnmn54u 16 5 proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 16 6 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 16 7 too too RB work_7k7caouvh5efzjp7ikemnmn54u 16 8 complicated complicated JJ work_7k7caouvh5efzjp7ikemnmn54u 16 9 to to TO work_7k7caouvh5efzjp7ikemnmn54u 16 10 allow allow VB work_7k7caouvh5efzjp7ikemnmn54u 16 11 exact exact JJ work_7k7caouvh5efzjp7ikemnmn54u 16 12 modeling modeling NN work_7k7caouvh5efzjp7ikemnmn54u 16 13 — — : work_7k7caouvh5efzjp7ikemnmn54u 16 14 some some DT work_7k7caouvh5efzjp7ikemnmn54u 16 15 simplifications simplification NNS work_7k7caouvh5efzjp7ikemnmn54u 16 16 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 16 17 necessary necessary JJ work_7k7caouvh5efzjp7ikemnmn54u 16 18 already already RB work_7k7caouvh5efzjp7ikemnmn54u 16 19 at at IN work_7k7caouvh5efzjp7ikemnmn54u 16 20 the the DT work_7k7caouvh5efzjp7ikemnmn54u 16 21 stage stage NN work_7k7caouvh5efzjp7ikemnmn54u 16 22 of of IN work_7k7caouvh5efzjp7ikemnmn54u 16 23 initial initial JJ work_7k7caouvh5efzjp7ikemnmn54u 16 24 formulation formulation NN work_7k7caouvh5efzjp7ikemnmn54u 16 25 of of IN work_7k7caouvh5efzjp7ikemnmn54u 16 26 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 16 27 . . . work_7k7caouvh5efzjp7ikemnmn54u 17 1 The the DT work_7k7caouvh5efzjp7ikemnmn54u 17 2 crucial crucial JJ work_7k7caouvh5efzjp7ikemnmn54u 17 3 issue issue NN work_7k7caouvh5efzjp7ikemnmn54u 17 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 17 5 common common JJ work_7k7caouvh5efzjp7ikemnmn54u 17 6 to to IN work_7k7caouvh5efzjp7ikemnmn54u 17 7 any any DT work_7k7caouvh5efzjp7ikemnmn54u 17 8 theoretical theoretical JJ work_7k7caouvh5efzjp7ikemnmn54u 17 9 analysis analysis NN work_7k7caouvh5efzjp7ikemnmn54u 17 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 17 11 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 17 12 where where WRB work_7k7caouvh5efzjp7ikemnmn54u 17 13 to to TO work_7k7caouvh5efzjp7ikemnmn54u 17 14 draw draw VB work_7k7caouvh5efzjp7ikemnmn54u 17 15 ‘ ' `` work_7k7caouvh5efzjp7ikemnmn54u 17 16 a a DT work_7k7caouvh5efzjp7ikemnmn54u 17 17 line line NN work_7k7caouvh5efzjp7ikemnmn54u 17 18 in in IN work_7k7caouvh5efzjp7ikemnmn54u 17 19 the the DT work_7k7caouvh5efzjp7ikemnmn54u 17 20 sand sand NN work_7k7caouvh5efzjp7ikemnmn54u 17 21 ’ ' '' work_7k7caouvh5efzjp7ikemnmn54u 17 22 , , , work_7k7caouvh5efzjp7ikemnmn54u 17 23 i.e. i.e. FW work_7k7caouvh5efzjp7ikemnmn54u 18 1 what what WDT work_7k7caouvh5efzjp7ikemnmn54u 18 2 degree degree NN work_7k7caouvh5efzjp7ikemnmn54u 18 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 18 4 simplifica- simplifica- NN work_7k7caouvh5efzjp7ikemnmn54u 18 5 tion tion NN work_7k7caouvh5efzjp7ikemnmn54u 18 6 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 18 7 acceptable acceptable JJ work_7k7caouvh5efzjp7ikemnmn54u 18 8 without without IN work_7k7caouvh5efzjp7ikemnmn54u 18 9 ‘ ' `` work_7k7caouvh5efzjp7ikemnmn54u 18 10 throwing throw VBG work_7k7caouvh5efzjp7ikemnmn54u 18 11 the the DT work_7k7caouvh5efzjp7ikemnmn54u 18 12 baby baby NN work_7k7caouvh5efzjp7ikemnmn54u 18 13 out out RP work_7k7caouvh5efzjp7ikemnmn54u 18 14 with with IN work_7k7caouvh5efzjp7ikemnmn54u 18 15 the the DT work_7k7caouvh5efzjp7ikemnmn54u 18 16 bath bath NN work_7k7caouvh5efzjp7ikemnmn54u 18 17 water water NN work_7k7caouvh5efzjp7ikemnmn54u 18 18 ’ ' '' work_7k7caouvh5efzjp7ikemnmn54u 18 19 . . . work_7k7caouvh5efzjp7ikemnmn54u 19 1 A a DT work_7k7caouvh5efzjp7ikemnmn54u 19 2 useful useful JJ work_7k7caouvh5efzjp7ikemnmn54u 19 3 model model NN work_7k7caouvh5efzjp7ikemnmn54u 19 4 must must MD work_7k7caouvh5efzjp7ikemnmn54u 19 5 exhibit exhibit VB work_7k7caouvh5efzjp7ikemnmn54u 19 6 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 19 7 in in IN work_7k7caouvh5efzjp7ikemnmn54u 19 8 an an DT work_7k7caouvh5efzjp7ikemnmn54u 19 9 unbiased unbiased JJ work_7k7caouvh5efzjp7ikemnmn54u 19 10 simulation simulation NN work_7k7caouvh5efzjp7ikemnmn54u 19 11 and and CC work_7k7caouvh5efzjp7ikemnmn54u 19 12 , , , work_7k7caouvh5efzjp7ikemnmn54u 19 13 moreover moreover RB work_7k7caouvh5efzjp7ikemnmn54u 19 14 , , , work_7k7caouvh5efzjp7ikemnmn54u 19 15 should should MD work_7k7caouvh5efzjp7ikemnmn54u 19 16 allow allow VB work_7k7caouvh5efzjp7ikemnmn54u 19 17 for for IN work_7k7caouvh5efzjp7ikemnmn54u 19 18 hun- hun- JJ work_7k7caouvh5efzjp7ikemnmn54u 19 19 dreds dred NNS work_7k7caouvh5efzjp7ikemnmn54u 19 20 of of IN work_7k7caouvh5efzjp7ikemnmn54u 19 21 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 19 22 events event NNS work_7k7caouvh5efzjp7ikemnmn54u 19 23 to to TO work_7k7caouvh5efzjp7ikemnmn54u 19 24 occur occur VB work_7k7caouvh5efzjp7ikemnmn54u 19 25 . . . work_7k7caouvh5efzjp7ikemnmn54u 20 1 The the DT work_7k7caouvh5efzjp7ikemnmn54u 20 2 latter latter JJ work_7k7caouvh5efzjp7ikemnmn54u 20 3 requirement requirement NN work_7k7caouvh5efzjp7ikemnmn54u 20 4 follows follow VBZ work_7k7caouvh5efzjp7ikemnmn54u 20 5 from from IN work_7k7caouvh5efzjp7ikemnmn54u 20 6 the the DT work_7k7caouvh5efzjp7ikemnmn54u 20 7 fact fact NN work_7k7caouvh5efzjp7ikemnmn54u 20 8 that that IN work_7k7caouvh5efzjp7ikemnmn54u 20 9 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 20 10 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 20 11 an an DT work_7k7caouvh5efzjp7ikemnmn54u 20 12 intrinsically intrinsically RB work_7k7caouvh5efzjp7ikemnmn54u 20 13 statisti- statisti- JJ work_7k7caouvh5efzjp7ikemnmn54u 20 14 cal cal NN work_7k7caouvh5efzjp7ikemnmn54u 20 15 phenomenon phenomenon NN work_7k7caouvh5efzjp7ikemnmn54u 20 16 and and CC work_7k7caouvh5efzjp7ikemnmn54u 20 17 no no DT work_7k7caouvh5efzjp7ikemnmn54u 20 18 conclusion conclusion NN work_7k7caouvh5efzjp7ikemnmn54u 20 19 can can MD work_7k7caouvh5efzjp7ikemnmn54u 20 20 be be VB work_7k7caouvh5efzjp7ikemnmn54u 20 21 derived derive VBN work_7k7caouvh5efzjp7ikemnmn54u 20 22 from from IN work_7k7caouvh5efzjp7ikemnmn54u 20 23 a a DT work_7k7caouvh5efzjp7ikemnmn54u 20 24 single single JJ work_7k7caouvh5efzjp7ikemnmn54u 20 25 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 20 26 or or CC work_7k7caouvh5efzjp7ikemnmn54u 20 27 unfolding unfold VBG work_7k7caouvh5efzjp7ikemnmn54u 20 28 trajectory trajectory CD work_7k7caouvh5efzjp7ikemnmn54u 20 29 . . . work_7k7caouvh5efzjp7ikemnmn54u 21 1 Currently currently RB work_7k7caouvh5efzjp7ikemnmn54u 21 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 21 3 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 21 4 simulations simulation NNS work_7k7caouvh5efzjp7ikemnmn54u 21 5 satisfying satisfy VBG work_7k7caouvh5efzjp7ikemnmn54u 21 6 these these DT work_7k7caouvh5efzjp7ikemnmn54u 21 7 important important JJ work_7k7caouvh5efzjp7ikemnmn54u 21 8 requirements requirement NNS work_7k7caouvh5efzjp7ikemnmn54u 21 9 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 21 10 feasible feasible JJ work_7k7caouvh5efzjp7ikemnmn54u 21 11 only only RB work_7k7caouvh5efzjp7ikemnmn54u 21 12 in in IN work_7k7caouvh5efzjp7ikemnmn54u 21 13 the the DT work_7k7caouvh5efzjp7ikemnmn54u 21 14 context context NN work_7k7caouvh5efzjp7ikemnmn54u 21 15 of of IN work_7k7caouvh5efzjp7ikemnmn54u 21 16 simplified simplify VBN work_7k7caouvh5efzjp7ikemnmn54u 21 17 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 21 18 and and CC work_7k7caouvh5efzjp7ikemnmn54u 21 19 off- off- JJ work_7k7caouvh5efzjp7ikemnmn54u 21 20 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 21 21 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 21 22 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 21 23 most most JJS work_7k7caouvh5efzjp7ikemnmn54u 21 24 of of IN work_7k7caouvh5efzjp7ikemnmn54u 21 25 these these DT work_7k7caouvh5efzjp7ikemnmn54u 21 26 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 21 27 ‘ ' `` work_7k7caouvh5efzjp7ikemnmn54u 21 28 sidechain sidechain JJ work_7k7caouvh5efzjp7ikemnmn54u 21 29 - - : work_7k7caouvh5efzjp7ikemnmn54u 21 30 only only RB work_7k7caouvh5efzjp7ikemnmn54u 21 31 ’ ' '' work_7k7caouvh5efzjp7ikemnmn54u 21 32 , , , work_7k7caouvh5efzjp7ikemnmn54u 21 33 in in IN work_7k7caouvh5efzjp7ikemnmn54u 21 34 the the DT work_7k7caouvh5efzjp7ikemnmn54u 21 35 terminology terminology NN work_7k7caouvh5efzjp7ikemnmn54u 21 36 of of IN work_7k7caouvh5efzjp7ikemnmn54u 21 37 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 21 38 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 21 39 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 21 40 ; ; , work_7k7caouvh5efzjp7ikemnmn54u 21 41 e.g. e.g. RB work_7k7caouvh5efzjp7ikemnmn54u 22 1 see see VB work_7k7caouvh5efzjp7ikemnmn54u 22 2 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 22 3 2–12 2–12 CD work_7k7caouvh5efzjp7ikemnmn54u 22 4 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 22 5 and and CC work_7k7caouvh5efzjp7ikemnmn54u 22 6 references reference NNS work_7k7caouvh5efzjp7ikemnmn54u 22 7 therein therein RB work_7k7caouvh5efzjp7ikemnmn54u 22 8 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 22 9 . . . work_7k7caouvh5efzjp7ikemnmn54u 23 1 It -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 23 2 was be VBD work_7k7caouvh5efzjp7ikemnmn54u 23 3 suggested suggest VBN work_7k7caouvh5efzjp7ikemnmn54u 23 4 by by IN work_7k7caouvh5efzjp7ikemnmn54u 23 5 Honig Honig NNP work_7k7caouvh5efzjp7ikemnmn54u 23 6 and and CC work_7k7caouvh5efzjp7ikemnmn54u 23 7 Cohen Cohen NNP work_7k7caouvh5efzjp7ikemnmn54u 23 8 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 23 9 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 23 10 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 23 11 that that IN work_7k7caouvh5efzjp7ikemnmn54u 23 12 such such JJ work_7k7caouvh5efzjp7ikemnmn54u 23 13 “ " `` work_7k7caouvh5efzjp7ikemnmn54u 23 14 sidechain sidechain NN work_7k7caouvh5efzjp7ikemnmn54u 23 15 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 23 16 only only RB work_7k7caouvh5efzjp7ikemnmn54u 23 17 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 23 18 fail fail VBP work_7k7caouvh5efzjp7ikemnmn54u 23 19 to to TO work_7k7caouvh5efzjp7ikemnmn54u 23 20 capture capture VB work_7k7caouvh5efzjp7ikemnmn54u 23 21 essential essential JJ work_7k7caouvh5efzjp7ikemnmn54u 23 22 features feature NNS work_7k7caouvh5efzjp7ikemnmn54u 23 23 of of IN work_7k7caouvh5efzjp7ikemnmn54u 23 24 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 23 25 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 23 26 . . . work_7k7caouvh5efzjp7ikemnmn54u 23 27 ” " '' work_7k7caouvh5efzjp7ikemnmn54u 23 28 The the DT work_7k7caouvh5efzjp7ikemnmn54u 23 29 existing exist VBG work_7k7caouvh5efzjp7ikemnmn54u 23 30 gap gap NN work_7k7caouvh5efzjp7ikemnmn54u 23 31 between between IN work_7k7caouvh5efzjp7ikemnmn54u 23 32 foldable foldable JJ work_7k7caouvh5efzjp7ikemnmn54u 23 33 and and CC work_7k7caouvh5efzjp7ikemnmn54u 23 34 detailed detailed JJ work_7k7caouvh5efzjp7ikemnmn54u 23 35 atomistic atomistic JJ work_7k7caouvh5efzjp7ikemnmn54u 23 36 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 23 37 leaves leave VBZ work_7k7caouvh5efzjp7ikemnmn54u 23 38 us -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 23 39 no no DT work_7k7caouvh5efzjp7ikemnmn54u 23 40 choice choice NN work_7k7caouvh5efzjp7ikemnmn54u 23 41 other other JJ work_7k7caouvh5efzjp7ikemnmn54u 23 42 than than IN work_7k7caouvh5efzjp7ikemnmn54u 23 43 to to TO work_7k7caouvh5efzjp7ikemnmn54u 23 44 study study VB work_7k7caouvh5efzjp7ikemnmn54u 23 45 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 23 46 mechanisms mechanism NNS work_7k7caouvh5efzjp7ikemnmn54u 23 47 using use VBG work_7k7caouvh5efzjp7ikemnmn54u 23 48 simplified simplify VBN work_7k7caouvh5efzjp7ikemnmn54u 23 49 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 23 50 , , , work_7k7caouvh5efzjp7ikemnmn54u 23 51 benchmarking benchmarke VBG work_7k7caouvh5efzjp7ikemnmn54u 23 52 them -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 23 53 against against IN work_7k7caouvh5efzjp7ikemnmn54u 23 54 experiment experiment NN work_7k7caouvh5efzjp7ikemnmn54u 23 55 . . . work_7k7caouvh5efzjp7ikemnmn54u 24 1 After after RB work_7k7caouvh5efzjp7ikemnmn54u 24 2 all all RB work_7k7caouvh5efzjp7ikemnmn54u 24 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 24 4 how how WRB work_7k7caouvh5efzjp7ikemnmn54u 24 5 should should MD work_7k7caouvh5efzjp7ikemnmn54u 24 6 theory theory NN work_7k7caouvh5efzjp7ikemnmn54u 24 7 be be VB work_7k7caouvh5efzjp7ikemnmn54u 24 8 judged judge VBN work_7k7caouvh5efzjp7ikemnmn54u 24 9 ? ? . work_7k7caouvh5efzjp7ikemnmn54u 25 1 By by IN work_7k7caouvh5efzjp7ikemnmn54u 25 2 its -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 25 3 ability ability NN work_7k7caouvh5efzjp7ikemnmn54u 25 4 to to TO work_7k7caouvh5efzjp7ikemnmn54u 25 5 explain explain VB work_7k7caouvh5efzjp7ikemnmn54u 25 6 existing exist VBG work_7k7caouvh5efzjp7ikemnmn54u 25 7 experiments experiment NNS work_7k7caouvh5efzjp7ikemnmn54u 25 8 and and CC work_7k7caouvh5efzjp7ikemnmn54u 25 9 to to TO work_7k7caouvh5efzjp7ikemnmn54u 25 10 predict predict VB work_7k7caouvh5efzjp7ikemnmn54u 25 11 the the DT work_7k7caouvh5efzjp7ikemnmn54u 25 12 results result NNS work_7k7caouvh5efzjp7ikemnmn54u 25 13 of of IN work_7k7caouvh5efzjp7ikemnmn54u 25 14 future future JJ work_7k7caouvh5efzjp7ikemnmn54u 25 15 experiments experiment NNS work_7k7caouvh5efzjp7ikemnmn54u 25 16 . . . work_7k7caouvh5efzjp7ikemnmn54u 26 1 In in IN work_7k7caouvh5efzjp7ikemnmn54u 26 2 this this DT work_7k7caouvh5efzjp7ikemnmn54u 26 3 regard regard NN work_7k7caouvh5efzjp7ikemnmn54u 26 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 26 5 contrary contrary RB work_7k7caouvh5efzjp7ikemnmn54u 26 6 to to IN work_7k7caouvh5efzjp7ikemnmn54u 26 7 the the DT work_7k7caouvh5efzjp7ikemnmn54u 26 8 assertions assertion NNS work_7k7caouvh5efzjp7ikemnmn54u 26 9 of of IN work_7k7caouvh5efzjp7ikemnmn54u 26 10 Honig Honig NNP work_7k7caouvh5efzjp7ikemnmn54u 26 11 and and CC work_7k7caouvh5efzjp7ikemnmn54u 26 12 Cohen Cohen NNP work_7k7caouvh5efzjp7ikemnmn54u 26 13 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 26 14 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 26 15 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 26 16 , , , work_7k7caouvh5efzjp7ikemnmn54u 26 17 simpli- simpli- JJ work_7k7caouvh5efzjp7ikemnmn54u 26 18 fied fie VBN work_7k7caouvh5efzjp7ikemnmn54u 26 19 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 26 20 provide provide VBP work_7k7caouvh5efzjp7ikemnmn54u 26 21 valuable valuable JJ work_7k7caouvh5efzjp7ikemnmn54u 26 22 insights insight NNS work_7k7caouvh5efzjp7ikemnmn54u 26 23 into into IN work_7k7caouvh5efzjp7ikemnmn54u 26 24 the the DT work_7k7caouvh5efzjp7ikemnmn54u 26 25 basic basic JJ work_7k7caouvh5efzjp7ikemnmn54u 26 26 princi- princi- NN work_7k7caouvh5efzjp7ikemnmn54u 26 27 ples ple NNS work_7k7caouvh5efzjp7ikemnmn54u 26 28 of of IN work_7k7caouvh5efzjp7ikemnmn54u 26 29 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 26 30 stability stability NN work_7k7caouvh5efzjp7ikemnmn54u 26 31 and and CC work_7k7caouvh5efzjp7ikemnmn54u 26 32 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 26 33 . . . work_7k7caouvh5efzjp7ikemnmn54u 27 1 First first RB work_7k7caouvh5efzjp7ikemnmn54u 27 2 of of IN work_7k7caouvh5efzjp7ikemnmn54u 27 3 all all DT work_7k7caouvh5efzjp7ikemnmn54u 27 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 27 5 the the DT work_7k7caouvh5efzjp7ikemnmn54u 27 6 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 27 7 model model NN work_7k7caouvh5efzjp7ikemnmn54u 27 8 captures capture VBZ work_7k7caouvh5efzjp7ikemnmn54u 27 9 one one CD work_7k7caouvh5efzjp7ikemnmn54u 27 10 of of IN work_7k7caouvh5efzjp7ikemnmn54u 27 11 the the DT work_7k7caouvh5efzjp7ikemnmn54u 27 12 most most JJS work_7k7caouvh5efzjp7ikemnmn54u 27 13 fas- fas- NN work_7k7caouvh5efzjp7ikemnmn54u 27 14 cinating cinating NN work_7k7caouvh5efzjp7ikemnmn54u 27 15 and and CC work_7k7caouvh5efzjp7ikemnmn54u 27 16 important important JJ work_7k7caouvh5efzjp7ikemnmn54u 27 17 features feature NNS work_7k7caouvh5efzjp7ikemnmn54u 27 18 of of IN work_7k7caouvh5efzjp7ikemnmn54u 27 19 proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 27 20 — — : work_7k7caouvh5efzjp7ikemnmn54u 27 21 cooperativ- cooperativ- JJ work_7k7caouvh5efzjp7ikemnmn54u 27 22 ity ity NN work_7k7caouvh5efzjp7ikemnmn54u 27 23 of of IN work_7k7caouvh5efzjp7ikemnmn54u 27 24 their -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 27 25 structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 27 26 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 27 27 6,7,13–16 6,7,13–16 NN work_7k7caouvh5efzjp7ikemnmn54u 27 28 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 27 29 . . . work_7k7caouvh5efzjp7ikemnmn54u 28 1 Contrary contrary JJ work_7k7caouvh5efzjp7ikemnmn54u 28 2 to to IN work_7k7caouvh5efzjp7ikemnmn54u 28 3 a a DT work_7k7caouvh5efzjp7ikemnmn54u 28 4 popular popular JJ work_7k7caouvh5efzjp7ikemnmn54u 28 5 but but CC work_7k7caouvh5efzjp7ikemnmn54u 28 6 incorrect incorrect JJ work_7k7caouvh5efzjp7ikemnmn54u 28 7 view view NN work_7k7caouvh5efzjp7ikemnmn54u 28 8 , , , work_7k7caouvh5efzjp7ikemnmn54u 28 9 helix helix NN work_7k7caouvh5efzjp7ikemnmn54u 28 10 / / SYM work_7k7caouvh5efzjp7ikemnmn54u 28 11 coil coil NN work_7k7caouvh5efzjp7ikemnmn54u 28 12 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 28 13 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 28 14 not not RB work_7k7caouvh5efzjp7ikemnmn54u 28 15 truly truly RB work_7k7caouvh5efzjp7ikemnmn54u 28 16 cooperative cooperative JJ work_7k7caouvh5efzjp7ikemnmn54u 28 17 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 28 18 not not RB work_7k7caouvh5efzjp7ikemnmn54u 28 19 a a DT work_7k7caouvh5efzjp7ikemnmn54u 28 20 first first JJ work_7k7caouvh5efzjp7ikemnmn54u 28 21 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 28 22 order order NN work_7k7caouvh5efzjp7ikemnmn54u 28 23 type type NN work_7k7caouvh5efzjp7ikemnmn54u 28 24 , , , work_7k7caouvh5efzjp7ikemnmn54u 28 25 e.g. e.g. RB work_7k7caouvh5efzjp7ikemnmn54u 29 1 see see VB work_7k7caouvh5efzjp7ikemnmn54u 29 2 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 29 3 11 11 CD work_7k7caouvh5efzjp7ikemnmn54u 29 4 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 29 5 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 29 6 . . . work_7k7caouvh5efzjp7ikemnmn54u 30 1 The the DT work_7k7caouvh5efzjp7ikemnmn54u 30 2 reason reason NN work_7k7caouvh5efzjp7ikemnmn54u 30 3 for for IN work_7k7caouvh5efzjp7ikemnmn54u 30 4 this this DT work_7k7caouvh5efzjp7ikemnmn54u 30 5 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 30 6 given give VBN work_7k7caouvh5efzjp7ikemnmn54u 30 7 by by IN work_7k7caouvh5efzjp7ikemnmn54u 30 8 the the DT work_7k7caouvh5efzjp7ikemnmn54u 30 9 Landau Landau NNP work_7k7caouvh5efzjp7ikemnmn54u 30 10 theorem theorem NN work_7k7caouvh5efzjp7ikemnmn54u 30 11 , , , work_7k7caouvh5efzjp7ikemnmn54u 30 12 which which WDT work_7k7caouvh5efzjp7ikemnmn54u 30 13 prohibits prohibit VBZ work_7k7caouvh5efzjp7ikemnmn54u 30 14 stable stable JJ work_7k7caouvh5efzjp7ikemnmn54u 30 15 phases phase NNS work_7k7caouvh5efzjp7ikemnmn54u 30 16 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 30 17 such such JJ work_7k7caouvh5efzjp7ikemnmn54u 30 18 as as IN work_7k7caouvh5efzjp7ikemnmn54u 30 19 one one CD work_7k7caouvh5efzjp7ikemnmn54u 30 20 long long JJ work_7k7caouvh5efzjp7ikemnmn54u 30 21 helix helix NN work_7k7caouvh5efzjp7ikemnmn54u 30 22 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 30 23 and and CC work_7k7caouvh5efzjp7ikemnmn54u 30 24 phase phase NN work_7k7caouvh5efzjp7ikemnmn54u 30 25 transitions transition NNS work_7k7caouvh5efzjp7ikemnmn54u 30 26 in in IN work_7k7caouvh5efzjp7ikemnmn54u 30 27 one one CD work_7k7caouvh5efzjp7ikemnmn54u 30 28 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 30 29 dimensional dimensional JJ work_7k7caouvh5efzjp7ikemnmn54u 30 30 systems system NNS work_7k7caouvh5efzjp7ikemnmn54u 30 31 without without IN work_7k7caouvh5efzjp7ikemnmn54u 30 32 long long JJ work_7k7caouvh5efzjp7ikemnmn54u 30 33 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 30 34 range range NN work_7k7caouvh5efzjp7ikemnmn54u 30 35 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 30 36 in in IN work_7k7caouvh5efzjp7ikemnmn54u 30 37 space space NN work_7k7caouvh5efzjp7ikemnmn54u 30 38 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 30 39 interactions interaction NNS work_7k7caouvh5efzjp7ikemnmn54u 30 40 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 30 41 16 16 CD work_7k7caouvh5efzjp7ikemnmn54u 30 42 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 30 43 . . . work_7k7caouvh5efzjp7ikemnmn54u 31 1 This this DT work_7k7caouvh5efzjp7ikemnmn54u 31 2 means mean VBZ work_7k7caouvh5efzjp7ikemnmn54u 31 3 that that IN work_7k7caouvh5efzjp7ikemnmn54u 31 4 helix helix JJ work_7k7caouvh5efzjp7ikemnmn54u 31 5 decay decay NN work_7k7caouvh5efzjp7ikemnmn54u 31 6 and and CC work_7k7caouvh5efzjp7ikemnmn54u 31 7 formation formation NN work_7k7caouvh5efzjp7ikemnmn54u 31 8 can can MD work_7k7caouvh5efzjp7ikemnmn54u 31 9 not not RB work_7k7caouvh5efzjp7ikemnmn54u 31 10 account account VB work_7k7caouvh5efzjp7ikemnmn54u 31 11 for for IN work_7k7caouvh5efzjp7ikemnmn54u 31 12 cooperativity cooperativity NN work_7k7caouvh5efzjp7ikemnmn54u 31 13 of of IN work_7k7caouvh5efzjp7ikemnmn54u 31 14 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 31 15 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 31 16 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 31 17 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 31 18 17 17 CD work_7k7caouvh5efzjp7ikemnmn54u 31 19 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 31 20 . . . work_7k7caouvh5efzjp7ikemnmn54u 32 1 A a DT work_7k7caouvh5efzjp7ikemnmn54u 32 2 clear clear JJ work_7k7caouvh5efzjp7ikemnmn54u 32 3 example example NN work_7k7caouvh5efzjp7ikemnmn54u 32 4 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 32 5 the the DT work_7k7caouvh5efzjp7ikemnmn54u 32 6 non non JJ work_7k7caouvh5efzjp7ikemnmn54u 32 7 - - JJ work_7k7caouvh5efzjp7ikemnmn54u 32 8 cooperative cooperative JJ work_7k7caouvh5efzjp7ikemnmn54u 32 9 character character NN work_7k7caouvh5efzjp7ikemnmn54u 32 10 of of IN work_7k7caouvh5efzjp7ikemnmn54u 32 11 unfolding unfolding NN work_7k7caouvh5efzjp7ikemnmn54u 32 12 of of IN work_7k7caouvh5efzjp7ikemnmn54u 32 13 the the DT work_7k7caouvh5efzjp7ikemnmn54u 32 14 molten molten JJ work_7k7caouvh5efzjp7ikemnmn54u 32 15 globule globule NN work_7k7caouvh5efzjp7ikemnmn54u 32 16 state state NN work_7k7caouvh5efzjp7ikemnmn54u 32 17 of of IN work_7k7caouvh5efzjp7ikemnmn54u 32 18 myoglobin myoglobin NN work_7k7caouvh5efzjp7ikemnmn54u 32 19 which which WDT work_7k7caouvh5efzjp7ikemnmn54u 32 20 involves involve VBZ work_7k7caouvh5efzjp7ikemnmn54u 32 21 massive massive JJ work_7k7caouvh5efzjp7ikemnmn54u 32 22 helix helix NN work_7k7caouvh5efzjp7ikemnmn54u 32 23 breakdown breakdown NN work_7k7caouvh5efzjp7ikemnmn54u 32 24 but but CC work_7k7caouvh5efzjp7ikemnmn54u 32 25 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 32 26 non non JJ work_7k7caouvh5efzjp7ikemnmn54u 32 27 - - JJ work_7k7caouvh5efzjp7ikemnmn54u 32 28 cooperative cooperative JJ work_7k7caouvh5efzjp7ikemnmn54u 32 29 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 32 30 18 18 CD work_7k7caouvh5efzjp7ikemnmn54u 32 31 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 32 32 . . . work_7k7caouvh5efzjp7ikemnmn54u 33 1 A a DT work_7k7caouvh5efzjp7ikemnmn54u 33 2 virtue virtue NN work_7k7caouvh5efzjp7ikemnmn54u 33 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 33 4 simplified simplify VBN work_7k7caouvh5efzjp7ikemnmn54u 33 5 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 33 6 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 33 7 their -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 33 8 intimate intimate JJ work_7k7caouvh5efzjp7ikemnmn54u 33 9 connection connection NN work_7k7caouvh5efzjp7ikemnmn54u 33 10 with with IN work_7k7caouvh5efzjp7ikemnmn54u 33 11 statistical statistical JJ work_7k7caouvh5efzjp7ikemnmn54u 33 12 mechanics mechanic NNS work_7k7caouvh5efzjp7ikemnmn54u 33 13 . . . work_7k7caouvh5efzjp7ikemnmn54u 34 1 This this DT work_7k7caouvh5efzjp7ikemnmn54u 34 2 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 34 3 very very RB work_7k7caouvh5efzjp7ikemnmn54u 34 4 important important JJ work_7k7caouvh5efzjp7ikemnmn54u 34 5 , , , work_7k7caouvh5efzjp7ikemnmn54u 34 6 as as IN work_7k7caouvh5efzjp7ikemnmn54u 34 7 it -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 34 8 often often RB work_7k7caouvh5efzjp7ikemnmn54u 34 9 allows allow VBZ work_7k7caouvh5efzjp7ikemnmn54u 34 10 us -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 34 11 to to TO work_7k7caouvh5efzjp7ikemnmn54u 34 12 compare compare VB work_7k7caouvh5efzjp7ikemnmn54u 34 13 simulation simulation NN work_7k7caouvh5efzjp7ikemnmn54u 34 14 results result NNS work_7k7caouvh5efzjp7ikemnmn54u 34 15 with with IN work_7k7caouvh5efzjp7ikemnmn54u 34 16 statisti- statisti- NNP work_7k7caouvh5efzjp7ikemnmn54u 34 17 cal cal JJ work_7k7caouvh5efzjp7ikemnmn54u 34 18 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 34 19 mechanical mechanical JJ work_7k7caouvh5efzjp7ikemnmn54u 34 20 analytical analytical JJ work_7k7caouvh5efzjp7ikemnmn54u 34 21 theories theory NNS work_7k7caouvh5efzjp7ikemnmn54u 34 22 . . . work_7k7caouvh5efzjp7ikemnmn54u 35 1 As as IN work_7k7caouvh5efzjp7ikemnmn54u 35 2 the the DT work_7k7caouvh5efzjp7ikemnmn54u 35 3 two two CD work_7k7caouvh5efzjp7ikemnmn54u 35 4 approaches approach NNS work_7k7caouvh5efzjp7ikemnmn54u 35 5 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 35 6 analytical analytical JJ work_7k7caouvh5efzjp7ikemnmn54u 35 7 and and CC work_7k7caouvh5efzjp7ikemnmn54u 35 8 numeric numeric JJ work_7k7caouvh5efzjp7ikemnmn54u 35 9 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 35 10 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 35 11 often often RB work_7k7caouvh5efzjp7ikemnmn54u 35 12 complementary complementary JJ work_7k7caouvh5efzjp7ikemnmn54u 35 13 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 35 14 e.g. e.g. RB work_7k7caouvh5efzjp7ikemnmn54u 36 1 analytical analytical JJ work_7k7caouvh5efzjp7ikemnmn54u 36 2 theories theory NNS work_7k7caouvh5efzjp7ikemnmn54u 36 3 require require VBP work_7k7caouvh5efzjp7ikemnmn54u 36 4 a a DT work_7k7caouvh5efzjp7ikemnmn54u 36 5 large large JJ work_7k7caouvh5efzjp7ikemnmn54u 36 6 number number NN work_7k7caouvh5efzjp7ikemnmn54u 36 7 of of IN work_7k7caouvh5efzjp7ikemnmn54u 36 8 particles particle NNS work_7k7caouvh5efzjp7ikemnmn54u 36 9 , , , work_7k7caouvh5efzjp7ikemnmn54u 36 10 whereas whereas IN work_7k7caouvh5efzjp7ikemnmn54u 36 11 simulations simulation NNS work_7k7caouvh5efzjp7ikemnmn54u 36 12 often often RB work_7k7caouvh5efzjp7ikemnmn54u 36 13 restrict restrict VBP work_7k7caouvh5efzjp7ikemnmn54u 36 14 it -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 36 15 to to IN work_7k7caouvh5efzjp7ikemnmn54u 36 16 modest modest JJ work_7k7caouvh5efzjp7ikemnmn54u 36 17 values value NNS work_7k7caouvh5efzjp7ikemnmn54u 36 18 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 36 19 , , , work_7k7caouvh5efzjp7ikemnmn54u 36 20 the the DT work_7k7caouvh5efzjp7ikemnmn54u 36 21 correlation correlation NN work_7k7caouvh5efzjp7ikemnmn54u 36 22 between between IN work_7k7caouvh5efzjp7ikemnmn54u 36 23 them -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 36 24 brings bring VBZ work_7k7caouvh5efzjp7ikemnmn54u 36 25 more more JJR work_7k7caouvh5efzjp7ikemnmn54u 36 26 confidence confidence NN work_7k7caouvh5efzjp7ikemnmn54u 36 27 in in IN work_7k7caouvh5efzjp7ikemnmn54u 36 28 the the DT work_7k7caouvh5efzjp7ikemnmn54u 36 29 validity validity NN work_7k7caouvh5efzjp7ikemnmn54u 36 30 of of IN work_7k7caouvh5efzjp7ikemnmn54u 36 31 obtained obtain VBN work_7k7caouvh5efzjp7ikemnmn54u 36 32 results result NNS work_7k7caouvh5efzjp7ikemnmn54u 36 33 and and CC work_7k7caouvh5efzjp7ikemnmn54u 36 34 allows allow VBZ work_7k7caouvh5efzjp7ikemnmn54u 36 35 us -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 36 36 to to TO work_7k7caouvh5efzjp7ikemnmn54u 36 37 get get VB work_7k7caouvh5efzjp7ikemnmn54u 36 38 rid rid VBN work_7k7caouvh5efzjp7ikemnmn54u 36 39 of of IN work_7k7caouvh5efzjp7ikemnmn54u 36 40 arti- arti- NN work_7k7caouvh5efzjp7ikemnmn54u 36 41 facts fact NNS work_7k7caouvh5efzjp7ikemnmn54u 36 42 . . . work_7k7caouvh5efzjp7ikemnmn54u 37 1 An an DT work_7k7caouvh5efzjp7ikemnmn54u 37 2 important important JJ work_7k7caouvh5efzjp7ikemnmn54u 37 3 example example NN work_7k7caouvh5efzjp7ikemnmn54u 37 4 in in IN work_7k7caouvh5efzjp7ikemnmn54u 37 5 this this DT work_7k7caouvh5efzjp7ikemnmn54u 37 6 regard regard NN work_7k7caouvh5efzjp7ikemnmn54u 37 7 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 37 8 the the DT work_7k7caouvh5efzjp7ikemnmn54u 37 9 conver- conver- JJ work_7k7caouvh5efzjp7ikemnmn54u 37 10 gence gence NN work_7k7caouvh5efzjp7ikemnmn54u 37 11 of of IN work_7k7caouvh5efzjp7ikemnmn54u 37 12 analytical analytical JJ work_7k7caouvh5efzjp7ikemnmn54u 37 13 theories theory NNS work_7k7caouvh5efzjp7ikemnmn54u 37 14 and and CC work_7k7caouvh5efzjp7ikemnmn54u 37 15 numeric numeric JJ work_7k7caouvh5efzjp7ikemnmn54u 37 16 simulations simulation NNS work_7k7caouvh5efzjp7ikemnmn54u 37 17 on on IN work_7k7caouvh5efzjp7ikemnmn54u 37 18 the the DT work_7k7caouvh5efzjp7ikemnmn54u 37 19 explanation explanation NN work_7k7caouvh5efzjp7ikemnmn54u 37 20 of of IN work_7k7caouvh5efzjp7ikemnmn54u 37 21 the the DT work_7k7caouvh5efzjp7ikemnmn54u 37 22 basic basic JJ work_7k7caouvh5efzjp7ikemnmn54u 37 23 reason reason NN work_7k7caouvh5efzjp7ikemnmn54u 37 24 for for IN work_7k7caouvh5efzjp7ikemnmn54u 37 25 cooperative cooperative JJ work_7k7caouvh5efzjp7ikemnmn54u 37 26 behav- behav- NN work_7k7caouvh5efzjp7ikemnmn54u 37 27 ior ior NNP work_7k7caouvh5efzjp7ikemnmn54u 37 28 as as IN work_7k7caouvh5efzjp7ikemnmn54u 37 29 connected connect VBN work_7k7caouvh5efzjp7ikemnmn54u 37 30 with with IN work_7k7caouvh5efzjp7ikemnmn54u 37 31 the the DT work_7k7caouvh5efzjp7ikemnmn54u 37 32 non non JJ work_7k7caouvh5efzjp7ikemnmn54u 37 33 - - JJ work_7k7caouvh5efzjp7ikemnmn54u 37 34 randomness randomness JJ work_7k7caouvh5efzjp7ikemnmn54u 37 35 of of IN work_7k7caouvh5efzjp7ikemnmn54u 37 36 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 37 37 sequences sequence NNS work_7k7caouvh5efzjp7ikemnmn54u 37 38 , , , work_7k7caouvh5efzjp7ikemnmn54u 37 39 their -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 37 40 optimization optimization NN work_7k7caouvh5efzjp7ikemnmn54u 37 41 for for IN work_7k7caouvh5efzjp7ikemnmn54u 37 42 efficient efficient JJ work_7k7caouvh5efzjp7ikemnmn54u 37 43 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 37 44 and and CC work_7k7caouvh5efzjp7ikemnmn54u 37 45 higher high JJR work_7k7caouvh5efzjp7ikemnmn54u 37 46 stability stability NN work_7k7caouvh5efzjp7ikemnmn54u 37 47 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 37 48 7,14,19,20 7,14,19,20 NN work_7k7caouvh5efzjp7ikemnmn54u 37 49 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 37 50 . . . work_7k7caouvh5efzjp7ikemnmn54u 38 1 Random random JJ work_7k7caouvh5efzjp7ikemnmn54u 38 2 sequences sequence NNS work_7k7caouvh5efzjp7ikemnmn54u 38 3 were be VBD work_7k7caouvh5efzjp7ikemnmn54u 38 4 pre- pre- RB work_7k7caouvh5efzjp7ikemnmn54u 38 5 dicted dicte VBN work_7k7caouvh5efzjp7ikemnmn54u 38 6 to to TO work_7k7caouvh5efzjp7ikemnmn54u 38 7 exhibit exhibit VB work_7k7caouvh5efzjp7ikemnmn54u 38 8 noncooperative noncooperative JJ work_7k7caouvh5efzjp7ikemnmn54u 38 9 , , , work_7k7caouvh5efzjp7ikemnmn54u 38 10 diffuse diffuse NN work_7k7caouvh5efzjp7ikemnmn54u 38 11 transitions transition NNS work_7k7caouvh5efzjp7ikemnmn54u 38 12 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 38 13 6,7,21 6,7,21 NNP work_7k7caouvh5efzjp7ikemnmn54u 38 14 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 38 15 . . . work_7k7caouvh5efzjp7ikemnmn54u 39 1 This this DT work_7k7caouvh5efzjp7ikemnmn54u 39 2 prediction prediction NN work_7k7caouvh5efzjp7ikemnmn54u 39 3 has have VBZ work_7k7caouvh5efzjp7ikemnmn54u 39 4 been be VBN work_7k7caouvh5efzjp7ikemnmn54u 39 5 confirmed confirm VBN work_7k7caouvh5efzjp7ikemnmn54u 39 6 by by IN work_7k7caouvh5efzjp7ikemnmn54u 39 7 experi- experi- NNP work_7k7caouvh5efzjp7ikemnmn54u 39 8 ments ment NNS work_7k7caouvh5efzjp7ikemnmn54u 39 9 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 39 10 22,23 22,23 CD work_7k7caouvh5efzjp7ikemnmn54u 39 11 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 39 12 . . . work_7k7caouvh5efzjp7ikemnmn54u 40 1 Lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 40 2 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 40 3 capture capture VBP work_7k7caouvh5efzjp7ikemnmn54u 40 4 the the DT work_7k7caouvh5efzjp7ikemnmn54u 40 5 cooperative cooperative JJ work_7k7caouvh5efzjp7ikemnmn54u 40 6 character character NN work_7k7caouvh5efzjp7ikemnmn54u 40 7 of of IN work_7k7caouvh5efzjp7ikemnmn54u 40 8 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 40 9 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 40 10 and and CC work_7k7caouvh5efzjp7ikemnmn54u 40 11 therefore therefore RB work_7k7caouvh5efzjp7ikemnmn54u 40 12 , , , work_7k7caouvh5efzjp7ikemnmn54u 40 13 in in IN work_7k7caouvh5efzjp7ikemnmn54u 40 14 spite spite NN work_7k7caouvh5efzjp7ikemnmn54u 40 15 of of IN work_7k7caouvh5efzjp7ikemnmn54u 40 16 their -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 40 17 simplicity simplicity NN work_7k7caouvh5efzjp7ikemnmn54u 40 18 , , , work_7k7caouvh5efzjp7ikemnmn54u 40 19 they -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 40 20 provide provide VBP work_7k7caouvh5efzjp7ikemnmn54u 40 21 a a DT work_7k7caouvh5efzjp7ikemnmn54u 40 22 reasonable reasonable JJ work_7k7caouvh5efzjp7ikemnmn54u 40 23 estimate estimate NN work_7k7caouvh5efzjp7ikemnmn54u 40 24 of of IN work_7k7caouvh5efzjp7ikemnmn54u 40 25 generic generic JJ work_7k7caouvh5efzjp7ikemnmn54u 40 26 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 40 27 sta- sta- VB work_7k7caouvh5efzjp7ikemnmn54u 40 28 bility bility NN work_7k7caouvh5efzjp7ikemnmn54u 40 29 of of IN work_7k7caouvh5efzjp7ikemnmn54u 40 30 0.1 0.1 CD work_7k7caouvh5efzjp7ikemnmn54u 40 31 kcal kcal JJ work_7k7caouvh5efzjp7ikemnmn54u 40 32 M–1 M–1 NNP work_7k7caouvh5efzjp7ikemnmn54u 40 33 residue–1 residue–1 NNP work_7k7caouvh5efzjp7ikemnmn54u 40 34 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 40 35 24 24 CD work_7k7caouvh5efzjp7ikemnmn54u 40 36 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 40 37 , , , work_7k7caouvh5efzjp7ikemnmn54u 40 38 close close RB work_7k7caouvh5efzjp7ikemnmn54u 40 39 to to IN work_7k7caouvh5efzjp7ikemnmn54u 40 40 experimental experimental JJ work_7k7caouvh5efzjp7ikemnmn54u 40 41 values value NNS work_7k7caouvh5efzjp7ikemnmn54u 40 42 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 40 43 25 25 CD work_7k7caouvh5efzjp7ikemnmn54u 40 44 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 40 45 . . . work_7k7caouvh5efzjp7ikemnmn54u 41 1 This this DT work_7k7caouvh5efzjp7ikemnmn54u 41 2 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 41 3 a a DT work_7k7caouvh5efzjp7ikemnmn54u 41 4 better well JJR work_7k7caouvh5efzjp7ikemnmn54u 41 5 estimate estimate NN work_7k7caouvh5efzjp7ikemnmn54u 41 6 than than IN work_7k7caouvh5efzjp7ikemnmn54u 41 7 calculations calculation NNS work_7k7caouvh5efzjp7ikemnmn54u 41 8 within within IN work_7k7caouvh5efzjp7ikemnmn54u 41 9 a a DT work_7k7caouvh5efzjp7ikemnmn54u 41 10 much much RB work_7k7caouvh5efzjp7ikemnmn54u 41 11 more more RBR work_7k7caouvh5efzjp7ikemnmn54u 41 12 detailed detailed JJ work_7k7caouvh5efzjp7ikemnmn54u 41 13 ‘ ' `` work_7k7caouvh5efzjp7ikemnmn54u 41 14 backbone backbone NN work_7k7caouvh5efzjp7ikemnmn54u 41 15 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 41 16 centric centric NN work_7k7caouvh5efzjp7ikemnmn54u 41 17 ’ ' '' work_7k7caouvh5efzjp7ikemnmn54u 41 18 model model NN work_7k7caouvh5efzjp7ikemnmn54u 41 19 , , , work_7k7caouvh5efzjp7ikemnmn54u 41 20 which which WDT work_7k7caouvh5efzjp7ikemnmn54u 41 21 in in IN work_7k7caouvh5efzjp7ikemnmn54u 41 22 spite spite NN work_7k7caouvh5efzjp7ikemnmn54u 41 23 of of IN work_7k7caouvh5efzjp7ikemnmn54u 41 24 a a DT work_7k7caouvh5efzjp7ikemnmn54u 41 25 large large JJ work_7k7caouvh5efzjp7ikemnmn54u 41 26 number number NN work_7k7caouvh5efzjp7ikemnmn54u 41 27 of of IN work_7k7caouvh5efzjp7ikemnmn54u 41 28 parameters parameter NNS work_7k7caouvh5efzjp7ikemnmn54u 41 29 involved involve VBN work_7k7caouvh5efzjp7ikemnmn54u 41 30 in in IN work_7k7caouvh5efzjp7ikemnmn54u 41 31 many many JJ work_7k7caouvh5efzjp7ikemnmn54u 41 32 cases case NNS work_7k7caouvh5efzjp7ikemnmn54u 41 33 gives give VBZ work_7k7caouvh5efzjp7ikemnmn54u 41 34 estimates estimate NNS work_7k7caouvh5efzjp7ikemnmn54u 41 35 of of IN work_7k7caouvh5efzjp7ikemnmn54u 41 36 the the DT work_7k7caouvh5efzjp7ikemnmn54u 41 37 free free JJ work_7k7caouvh5efzjp7ikemnmn54u 41 38 energy energy NN work_7k7caouvh5efzjp7ikemnmn54u 41 39 of of IN work_7k7caouvh5efzjp7ikemnmn54u 41 40 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 41 41 more more JJR work_7k7caouvh5efzjp7ikemnmn54u 41 42 than than IN work_7k7caouvh5efzjp7ikemnmn54u 41 43 an an DT work_7k7caouvh5efzjp7ikemnmn54u 41 44 order order NN work_7k7caouvh5efzjp7ikemnmn54u 41 45 of of IN work_7k7caouvh5efzjp7ikemnmn54u 41 46 magnitude magnitude NN work_7k7caouvh5efzjp7ikemnmn54u 41 47 off off RP work_7k7caouvh5efzjp7ikemnmn54u 41 48 from from IN work_7k7caouvh5efzjp7ikemnmn54u 41 49 experimental experimental JJ work_7k7caouvh5efzjp7ikemnmn54u 41 50 values value NNS work_7k7caouvh5efzjp7ikemnmn54u 41 51 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 41 52 see see VB work_7k7caouvh5efzjp7ikemnmn54u 41 53 Fig Fig NNP work_7k7caouvh5efzjp7ikemnmn54u 41 54 . . . work_7k7caouvh5efzjp7ikemnmn54u 42 1 5c 5c CD work_7k7caouvh5efzjp7ikemnmn54u 42 2 in in IN work_7k7caouvh5efzjp7ikemnmn54u 42 3 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 42 4 26 26 CD work_7k7caouvh5efzjp7ikemnmn54u 42 5 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 42 6 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 42 7 . . . work_7k7caouvh5efzjp7ikemnmn54u 43 1 For for IN work_7k7caouvh5efzjp7ikemnmn54u 43 2 example example NN work_7k7caouvh5efzjp7ikemnmn54u 43 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 43 4 calculations calculation NNS work_7k7caouvh5efzjp7ikemnmn54u 43 5 in in IN work_7k7caouvh5efzjp7ikemnmn54u 43 6 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 43 7 26 26 CD work_7k7caouvh5efzjp7ikemnmn54u 43 8 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 43 9 estimate estimate NN work_7k7caouvh5efzjp7ikemnmn54u 43 10 myoglobin myoglobin NN work_7k7caouvh5efzjp7ikemnmn54u 43 11 stability stability NN work_7k7caouvh5efzjp7ikemnmn54u 43 12 to to TO work_7k7caouvh5efzjp7ikemnmn54u 43 13 be be VB work_7k7caouvh5efzjp7ikemnmn54u 43 14 greater great JJR work_7k7caouvh5efzjp7ikemnmn54u 43 15 than than IN work_7k7caouvh5efzjp7ikemnmn54u 43 16 150 150 CD work_7k7caouvh5efzjp7ikemnmn54u 43 17 kcal kcal JJ work_7k7caouvh5efzjp7ikemnmn54u 43 18 M–1 m–1 NN work_7k7caouvh5efzjp7ikemnmn54u 43 19 while while IN work_7k7caouvh5efzjp7ikemnmn54u 43 20 actually actually RB work_7k7caouvh5efzjp7ikemnmn54u 43 21 it -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 43 22 hardly hardly RB work_7k7caouvh5efzjp7ikemnmn54u 43 23 exceeds exceed VBZ work_7k7caouvh5efzjp7ikemnmn54u 43 24 10 10 CD work_7k7caouvh5efzjp7ikemnmn54u 43 25 kcal kcal JJ work_7k7caouvh5efzjp7ikemnmn54u 43 26 M–1 m–1 NN work_7k7caouvh5efzjp7ikemnmn54u 43 27 at at IN work_7k7caouvh5efzjp7ikemnmn54u 43 28 physiological physiological JJ work_7k7caouvh5efzjp7ikemnmn54u 43 29 conditions condition NNS work_7k7caouvh5efzjp7ikemnmn54u 43 30 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 43 31 25 25 CD work_7k7caouvh5efzjp7ikemnmn54u 43 32 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 43 33 . . . work_7k7caouvh5efzjp7ikemnmn54u 44 1 This this DT work_7k7caouvh5efzjp7ikemnmn54u 44 2 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 44 3 not not RB work_7k7caouvh5efzjp7ikemnmn54u 44 4 surprising surprising JJ work_7k7caouvh5efzjp7ikemnmn54u 44 5 because because IN work_7k7caouvh5efzjp7ikemnmn54u 44 6 the the DT work_7k7caouvh5efzjp7ikemnmn54u 44 7 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 44 8 free free JJ work_7k7caouvh5efzjp7ikemnmn54u 44 9 energy energy NN work_7k7caouvh5efzjp7ikemnmn54u 44 10 represents represent VBZ work_7k7caouvh5efzjp7ikemnmn54u 44 11 a a DT work_7k7caouvh5efzjp7ikemnmn54u 44 12 small small JJ work_7k7caouvh5efzjp7ikemnmn54u 44 13 differ- differ- NN work_7k7caouvh5efzjp7ikemnmn54u 44 14 ence ence NN work_7k7caouvh5efzjp7ikemnmn54u 44 15 between between IN work_7k7caouvh5efzjp7ikemnmn54u 44 16 two two CD work_7k7caouvh5efzjp7ikemnmn54u 44 17 large large JJ work_7k7caouvh5efzjp7ikemnmn54u 44 18 numbers number NNS work_7k7caouvh5efzjp7ikemnmn54u 44 19 — — : work_7k7caouvh5efzjp7ikemnmn54u 44 20 energetic energetic JJ work_7k7caouvh5efzjp7ikemnmn54u 44 21 contribu- contribu- JJ work_7k7caouvh5efzjp7ikemnmn54u 44 22 tions tion NNS work_7k7caouvh5efzjp7ikemnmn54u 44 23 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 44 24 roughly roughly RB work_7k7caouvh5efzjp7ikemnmn54u 44 25 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 44 26 kcal kcal JJ work_7k7caouvh5efzjp7ikemnmn54u 44 27 M–1 M–1 NNP work_7k7caouvh5efzjp7ikemnmn54u 44 28 residue–1 residue–1 NNP work_7k7caouvh5efzjp7ikemnmn54u 44 29 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 44 30 and and CC work_7k7caouvh5efzjp7ikemnmn54u 44 31 the the DT work_7k7caouvh5efzjp7ikemnmn54u 44 32 opposing oppose VBG work_7k7caouvh5efzjp7ikemnmn54u 44 33 entropic entropic JJ work_7k7caouvh5efzjp7ikemnmn54u 44 34 contributions contribution NNS work_7k7caouvh5efzjp7ikemnmn54u 44 35 of of IN work_7k7caouvh5efzjp7ikemnmn54u 44 36 the the DT work_7k7caouvh5efzjp7ikemnmn54u 44 37 same same JJ work_7k7caouvh5efzjp7ikemnmn54u 44 38 order order NN work_7k7caouvh5efzjp7ikemnmn54u 44 39 of of IN work_7k7caouvh5efzjp7ikemnmn54u 44 40 magnitude magnitude NN work_7k7caouvh5efzjp7ikemnmn54u 44 41 . . . work_7k7caouvh5efzjp7ikemnmn54u 45 1 Calculations calculation NNS work_7k7caouvh5efzjp7ikemnmn54u 45 2 that that WDT work_7k7caouvh5efzjp7ikemnmn54u 45 3 involve involve VBP work_7k7caouvh5efzjp7ikemnmn54u 45 4 many many JJ work_7k7caouvh5efzjp7ikemnmn54u 45 5 parameters parameter NNS work_7k7caouvh5efzjp7ikemnmn54u 45 6 but but CC work_7k7caouvh5efzjp7ikemnmn54u 45 7 fail fail VBP work_7k7caouvh5efzjp7ikemnmn54u 45 8 to to TO work_7k7caouvh5efzjp7ikemnmn54u 45 9 incorporate incorporate VB work_7k7caouvh5efzjp7ikemnmn54u 45 10 the the DT work_7k7caouvh5efzjp7ikemnmn54u 45 11 key key JJ work_7k7caouvh5efzjp7ikemnmn54u 45 12 physics physics NN work_7k7caouvh5efzjp7ikemnmn54u 45 13 of of IN work_7k7caouvh5efzjp7ikemnmn54u 45 14 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 45 15 — — : work_7k7caouvh5efzjp7ikemnmn54u 45 16 cooperativity cooperativity NN work_7k7caouvh5efzjp7ikemnmn54u 45 17 — — : work_7k7caouvh5efzjp7ikemnmn54u 45 18 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 45 19 not not RB work_7k7caouvh5efzjp7ikemnmn54u 45 20 likely likely JJ work_7k7caouvh5efzjp7ikemnmn54u 45 21 to to TO work_7k7caouvh5efzjp7ikemnmn54u 45 22 have have VB work_7k7caouvh5efzjp7ikemnmn54u 45 23 sufficient sufficient JJ work_7k7caouvh5efzjp7ikemnmn54u 45 24 precision precision NN work_7k7caouvh5efzjp7ikemnmn54u 45 25 to to TO work_7k7caouvh5efzjp7ikemnmn54u 45 26 give give VB work_7k7caouvh5efzjp7ikemnmn54u 45 27 a a DT work_7k7caouvh5efzjp7ikemnmn54u 45 28 reliable reliable JJ work_7k7caouvh5efzjp7ikemnmn54u 45 29 estimate estimate NN work_7k7caouvh5efzjp7ikemnmn54u 45 30 of of IN work_7k7caouvh5efzjp7ikemnmn54u 45 31 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 45 32 free free JJ work_7k7caouvh5efzjp7ikemnmn54u 45 33 energy energy NN work_7k7caouvh5efzjp7ikemnmn54u 45 34 of of IN work_7k7caouvh5efzjp7ikemnmn54u 45 35 an an DT work_7k7caouvh5efzjp7ikemnmn54u 45 36 individual individual JJ work_7k7caouvh5efzjp7ikemnmn54u 45 37 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 45 38 . . . work_7k7caouvh5efzjp7ikemnmn54u 46 1 Another another DT work_7k7caouvh5efzjp7ikemnmn54u 46 2 important important JJ work_7k7caouvh5efzjp7ikemnmn54u 46 3 issue issue NN work_7k7caouvh5efzjp7ikemnmn54u 46 4 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 46 5 how how WRB work_7k7caouvh5efzjp7ikemnmn54u 46 6 simplified simplified JJ work_7k7caouvh5efzjp7ikemnmn54u 46 7 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 46 8 treat treat VBP work_7k7caouvh5efzjp7ikemnmn54u 46 9 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 46 10 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 46 11 kinetics kinetic NNS work_7k7caouvh5efzjp7ikemnmn54u 46 12 . . . work_7k7caouvh5efzjp7ikemnmn54u 47 1 The the DT work_7k7caouvh5efzjp7ikemnmn54u 47 2 simplification simplification NN work_7k7caouvh5efzjp7ikemnmn54u 47 3 introduced introduce VBN work_7k7caouvh5efzjp7ikemnmn54u 47 4 in in IN work_7k7caouvh5efzjp7ikemnmn54u 47 5 many many JJ work_7k7caouvh5efzjp7ikemnmn54u 47 6 — — : work_7k7caouvh5efzjp7ikemnmn54u 47 7 but but CC work_7k7caouvh5efzjp7ikemnmn54u 47 8 not not RB work_7k7caouvh5efzjp7ikemnmn54u 47 9 all all DT work_7k7caouvh5efzjp7ikemnmn54u 47 10 — — : work_7k7caouvh5efzjp7ikemnmn54u 47 11 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 47 12 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 47 13 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 47 14 that that IN work_7k7caouvh5efzjp7ikemnmn54u 47 15 they -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 47 16 do do VBP work_7k7caouvh5efzjp7ikemnmn54u 47 17 not not RB work_7k7caouvh5efzjp7ikemnmn54u 47 18 include include VB work_7k7caouvh5efzjp7ikemnmn54u 47 19 backbone backbone NN work_7k7caouvh5efzjp7ikemnmn54u 47 20 hydrogen hydrogen NN work_7k7caouvh5efzjp7ikemnmn54u 47 21 bonds bond NNS work_7k7caouvh5efzjp7ikemnmn54u 47 22 explicitly explicitly RB work_7k7caouvh5efzjp7ikemnmn54u 47 23 . . . work_7k7caouvh5efzjp7ikemnmn54u 48 1 Is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 48 2 this this DT work_7k7caouvh5efzjp7ikemnmn54u 48 3 factor factor NN work_7k7caouvh5efzjp7ikemnmn54u 48 4 crucial crucial JJ work_7k7caouvh5efzjp7ikemnmn54u 48 5 ? ? . work_7k7caouvh5efzjp7ikemnmn54u 49 1 Clearly clearly RB work_7k7caouvh5efzjp7ikemnmn54u 49 2 the the DT work_7k7caouvh5efzjp7ikemnmn54u 49 3 impact impact NN work_7k7caouvh5efzjp7ikemnmn54u 49 4 of of IN work_7k7caouvh5efzjp7ikemnmn54u 49 5 backbone backbone NN work_7k7caouvh5efzjp7ikemnmn54u 49 6 hydrogen hydrogen NN work_7k7caouvh5efzjp7ikemnmn54u 49 7 bonds bond NNS work_7k7caouvh5efzjp7ikemnmn54u 49 8 on on IN work_7k7caouvh5efzjp7ikemnmn54u 49 9 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 49 10 kinetics kinetic NNS work_7k7caouvh5efzjp7ikemnmn54u 49 11 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 49 12 essential essential JJ work_7k7caouvh5efzjp7ikemnmn54u 49 13 only only RB work_7k7caouvh5efzjp7ikemnmn54u 49 14 if if IN work_7k7caouvh5efzjp7ikemnmn54u 49 15 they -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 49 16 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 49 17 formed form VBN work_7k7caouvh5efzjp7ikemnmn54u 49 18 , , , work_7k7caouvh5efzjp7ikemnmn54u 49 19 to to IN work_7k7caouvh5efzjp7ikemnmn54u 49 20 a a DT work_7k7caouvh5efzjp7ikemnmn54u 49 21 con- con- NN work_7k7caouvh5efzjp7ikemnmn54u 49 22 siderable siderable JJ work_7k7caouvh5efzjp7ikemnmn54u 49 23 extent extent NN work_7k7caouvh5efzjp7ikemnmn54u 49 24 , , , work_7k7caouvh5efzjp7ikemnmn54u 49 25 before before IN work_7k7caouvh5efzjp7ikemnmn54u 49 26 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 49 27 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 49 28 state state NN work_7k7caouvh5efzjp7ikemnmn54u 49 29 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 49 30 reached reach VBN work_7k7caouvh5efzjp7ikemnmn54u 49 31 . . . work_7k7caouvh5efzjp7ikemnmn54u 50 1 In in IN work_7k7caouvh5efzjp7ikemnmn54u 50 2 this this DT work_7k7caouvh5efzjp7ikemnmn54u 50 3 regard regard NN work_7k7caouvh5efzjp7ikemnmn54u 50 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 50 5 Honig Honig NNP work_7k7caouvh5efzjp7ikemnmn54u 50 6 and and CC work_7k7caouvh5efzjp7ikemnmn54u 50 7 Cohen Cohen NNP work_7k7caouvh5efzjp7ikemnmn54u 50 8 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 50 9 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 50 10 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 50 11 refer refer VB work_7k7caouvh5efzjp7ikemnmn54u 50 12 to to IN work_7k7caouvh5efzjp7ikemnmn54u 50 13 two two CD work_7k7caouvh5efzjp7ikemnmn54u 50 14 papers paper NNS work_7k7caouvh5efzjp7ikemnmn54u 50 15 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 50 16 27,28 27,28 CD work_7k7caouvh5efzjp7ikemnmn54u 50 17 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 50 18 which which WDT work_7k7caouvh5efzjp7ikemnmn54u 50 19 concern concern NN work_7k7caouvh5efzjp7ikemnmn54u 50 20 unfolding unfold VBG work_7k7caouvh5efzjp7ikemnmn54u 50 21 intermediates intermediate NNS work_7k7caouvh5efzjp7ikemnmn54u 50 22 . . . work_7k7caouvh5efzjp7ikemnmn54u 51 1 In in IN work_7k7caouvh5efzjp7ikemnmn54u 51 2 their -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 51 3 view view NN work_7k7caouvh5efzjp7ikemnmn54u 51 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 51 5 the the DT work_7k7caouvh5efzjp7ikemnmn54u 51 6 results result NNS work_7k7caouvh5efzjp7ikemnmn54u 51 7 of of IN work_7k7caouvh5efzjp7ikemnmn54u 51 8 these these DT work_7k7caouvh5efzjp7ikemnmn54u 51 9 papers paper NNS work_7k7caouvh5efzjp7ikemnmn54u 51 10 suggest suggest VBP work_7k7caouvh5efzjp7ikemnmn54u 51 11 that that IN work_7k7caouvh5efzjp7ikemnmn54u 51 12 the the DT work_7k7caouvh5efzjp7ikemnmn54u 51 13 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 51 14 state state NN work_7k7caouvh5efzjp7ikemnmn54u 51 15 of of IN work_7k7caouvh5efzjp7ikemnmn54u 51 16 unfolding unfold VBG work_7k7caouvh5efzjp7ikemnmn54u 51 17 “ " `` work_7k7caouvh5efzjp7ikemnmn54u 51 18 appears appear NNS work_7k7caouvh5efzjp7ikemnmn54u 51 19 to to TO work_7k7caouvh5efzjp7ikemnmn54u 51 20 be be VB work_7k7caouvh5efzjp7ikemnmn54u 51 21 due due IN work_7k7caouvh5efzjp7ikemnmn54u 51 22 to to IN work_7k7caouvh5efzjp7ikemnmn54u 51 23 the the DT work_7k7caouvh5efzjp7ikemnmn54u 51 24 breaking breaking NN work_7k7caouvh5efzjp7ikemnmn54u 51 25 of of IN work_7k7caouvh5efzjp7ikemnmn54u 51 26 hydrogen hydrogen NN work_7k7caouvh5efzjp7ikemnmn54u 51 27 bonds bond NNS work_7k7caouvh5efzjp7ikemnmn54u 51 28 ” " '' work_7k7caouvh5efzjp7ikemnmn54u 51 29 . . . work_7k7caouvh5efzjp7ikemnmn54u 52 1 I -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 52 2 believe believe VBP work_7k7caouvh5efzjp7ikemnmn54u 52 3 that that IN work_7k7caouvh5efzjp7ikemnmn54u 52 4 this this DT work_7k7caouvh5efzjp7ikemnmn54u 52 5 conclusion conclusion NN work_7k7caouvh5efzjp7ikemnmn54u 52 6 does do VBZ work_7k7caouvh5efzjp7ikemnmn54u 52 7 not not RB work_7k7caouvh5efzjp7ikemnmn54u 52 8 follow follow VB work_7k7caouvh5efzjp7ikemnmn54u 52 9 from from IN work_7k7caouvh5efzjp7ikemnmn54u 52 10 the the DT work_7k7caouvh5efzjp7ikemnmn54u 52 11 experiments experiment NNS work_7k7caouvh5efzjp7ikemnmn54u 52 12 reported report VBN work_7k7caouvh5efzjp7ikemnmn54u 52 13 by by IN work_7k7caouvh5efzjp7ikemnmn54u 52 14 Baldwin Baldwin NNP work_7k7caouvh5efzjp7ikemnmn54u 52 15 and and CC work_7k7caouvh5efzjp7ikemnmn54u 52 16 co- co- JJ work_7k7caouvh5efzjp7ikemnmn54u 52 17 authors author NNS work_7k7caouvh5efzjp7ikemnmn54u 52 18 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 52 19 27,28 27,28 CD work_7k7caouvh5efzjp7ikemnmn54u 52 20 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 52 21 . . . work_7k7caouvh5efzjp7ikemnmn54u 53 1 What what WP work_7k7caouvh5efzjp7ikemnmn54u 53 2 they -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 53 3 actually actually RB work_7k7caouvh5efzjp7ikemnmn54u 53 4 show show VBP work_7k7caouvh5efzjp7ikemnmn54u 53 5 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 53 6 that that IN work_7k7caouvh5efzjp7ikemnmn54u 53 7 all all DT work_7k7caouvh5efzjp7ikemnmn54u 53 8 hydro- hydro- NN work_7k7caouvh5efzjp7ikemnmn54u 53 9 gen gen NNP work_7k7caouvh5efzjp7ikemnmn54u 53 10 bonds bond NNS work_7k7caouvh5efzjp7ikemnmn54u 53 11 get get VBP work_7k7caouvh5efzjp7ikemnmn54u 53 12 disrupted disrupt VBN work_7k7caouvh5efzjp7ikemnmn54u 53 13 at at IN work_7k7caouvh5efzjp7ikemnmn54u 53 14 the the DT work_7k7caouvh5efzjp7ikemnmn54u 53 15 rate rate NN work_7k7caouvh5efzjp7ikemnmn54u 53 16 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 53 17 limiting limit VBG work_7k7caouvh5efzjp7ikemnmn54u 53 18 step step NN work_7k7caouvh5efzjp7ikemnmn54u 53 19 of of IN work_7k7caouvh5efzjp7ikemnmn54u 53 20 unfolding unfolding NN work_7k7caouvh5efzjp7ikemnmn54u 53 21 , , , work_7k7caouvh5efzjp7ikemnmn54u 53 22 after after IN work_7k7caouvh5efzjp7ikemnmn54u 53 23 the the DT work_7k7caouvh5efzjp7ikemnmn54u 53 24 dry dry JJ work_7k7caouvh5efzjp7ikemnmn54u 53 25 molten molten JJ work_7k7caouvh5efzjp7ikemnmn54u 53 26 globule globule NN work_7k7caouvh5efzjp7ikemnmn54u 53 27 intermediate intermediate NN work_7k7caouvh5efzjp7ikemnmn54u 53 28 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 53 29 29 29 CD work_7k7caouvh5efzjp7ikemnmn54u 53 30 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 53 31 . . . work_7k7caouvh5efzjp7ikemnmn54u 54 1 That that DT work_7k7caouvh5efzjp7ikemnmn54u 54 2 does do VBZ work_7k7caouvh5efzjp7ikemnmn54u 54 3 not not RB work_7k7caouvh5efzjp7ikemnmn54u 54 4 imply imply VB work_7k7caouvh5efzjp7ikemnmn54u 54 5 that that IN work_7k7caouvh5efzjp7ikemnmn54u 54 6 hydrogen hydrogen NN work_7k7caouvh5efzjp7ikemnmn54u 54 7 bonds bond NNS work_7k7caouvh5efzjp7ikemnmn54u 54 8 break break VBP work_7k7caouvh5efzjp7ikemnmn54u 54 9 at at IN work_7k7caouvh5efzjp7ikemnmn54u 54 10 or or CC work_7k7caouvh5efzjp7ikemnmn54u 54 11 near near IN work_7k7caouvh5efzjp7ikemnmn54u 54 12 the the DT work_7k7caouvh5efzjp7ikemnmn54u 54 13 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 54 14 state state NN work_7k7caouvh5efzjp7ikemnmn54u 54 15 . . . work_7k7caouvh5efzjp7ikemnmn54u 55 1 In in IN work_7k7caouvh5efzjp7ikemnmn54u 55 2 fact fact NN work_7k7caouvh5efzjp7ikemnmn54u 55 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 55 4 as as IN work_7k7caouvh5efzjp7ikemnmn54u 55 5 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 55 6 from from IN work_7k7caouvh5efzjp7ikemnmn54u 55 7 the the DT work_7k7caouvh5efzjp7ikemnmn54u 55 8 dry dry JJ work_7k7caouvh5efzjp7ikemnmn54u 55 9 molten molten JJ work_7k7caouvh5efzjp7ikemnmn54u 55 10 globule globule NN work_7k7caouvh5efzjp7ikemnmn54u 55 11 unfolding unfold VBG work_7k7caouvh5efzjp7ikemnmn54u 55 12 intermediate intermediate JJ work_7k7caouvh5efzjp7ikemnmn54u 55 13 to to IN work_7k7caouvh5efzjp7ikemnmn54u 55 14 the the DT work_7k7caouvh5efzjp7ikemnmn54u 55 15 unfolded unfolded JJ work_7k7caouvh5efzjp7ikemnmn54u 55 16 state state NN work_7k7caouvh5efzjp7ikemnmn54u 55 17 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 55 18 two two CD work_7k7caouvh5efzjp7ikemnmn54u 55 19 state state NN work_7k7caouvh5efzjp7ikemnmn54u 55 20 , , , work_7k7caouvh5efzjp7ikemnmn54u 55 21 all all DT work_7k7caouvh5efzjp7ikemnmn54u 55 22 properties property NNS work_7k7caouvh5efzjp7ikemnmn54u 55 23 change change VBP work_7k7caouvh5efzjp7ikemnmn54u 55 24 with with IN work_7k7caouvh5efzjp7ikemnmn54u 55 25 the the DT work_7k7caouvh5efzjp7ikemnmn54u 55 26 same same JJ work_7k7caouvh5efzjp7ikemnmn54u 55 27 kinetic kinetic JJ work_7k7caouvh5efzjp7ikemnmn54u 55 28 exponent exponent NN work_7k7caouvh5efzjp7ikemnmn54u 55 29 . . . work_7k7caouvh5efzjp7ikemnmn54u 56 1 Therefore therefore RB work_7k7caouvh5efzjp7ikemnmn54u 56 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 56 3 it -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 56 4 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 56 5 impossible impossible JJ work_7k7caouvh5efzjp7ikemnmn54u 56 6 to to TO work_7k7caouvh5efzjp7ikemnmn54u 56 7 judge judge VB work_7k7caouvh5efzjp7ikemnmn54u 56 8 from from IN work_7k7caouvh5efzjp7ikemnmn54u 56 9 the the DT work_7k7caouvh5efzjp7ikemnmn54u 56 10 experiments experiment NNS work_7k7caouvh5efzjp7ikemnmn54u 56 11 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 56 12 27,28 27,28 CD work_7k7caouvh5efzjp7ikemnmn54u 56 13 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 56 14 at at IN work_7k7caouvh5efzjp7ikemnmn54u 56 15 what what WP work_7k7caouvh5efzjp7ikemnmn54u 56 16 point(s point(s NNP work_7k7caouvh5efzjp7ikemnmn54u 56 17 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 56 18 of of IN work_7k7caouvh5efzjp7ikemnmn54u 56 19 the the DT work_7k7caouvh5efzjp7ikemnmn54u 56 20 unfolding unfold VBG work_7k7caouvh5efzjp7ikemnmn54u 56 21 trajectories trajectory NNS work_7k7caouvh5efzjp7ikemnmn54u 56 22 overcoming overcome VBG work_7k7caouvh5efzjp7ikemnmn54u 56 23 the the DT work_7k7caouvh5efzjp7ikemnmn54u 56 24 major major JJ work_7k7caouvh5efzjp7ikemnmn54u 56 25 barrier barrier NN work_7k7caouvh5efzjp7ikemnmn54u 56 26 the the DT work_7k7caouvh5efzjp7ikemnmn54u 56 27 disruption disruption NN work_7k7caouvh5efzjp7ikemnmn54u 56 28 of of IN work_7k7caouvh5efzjp7ikemnmn54u 56 29 hydrogen hydrogen NNP work_7k7caouvh5efzjp7ikemnmn54u 56 30 bonds bond NNS work_7k7caouvh5efzjp7ikemnmn54u 56 31 occurs occur VBZ work_7k7caouvh5efzjp7ikemnmn54u 56 32 . . . work_7k7caouvh5efzjp7ikemnmn54u 57 1 Independently independently RB work_7k7caouvh5efzjp7ikemnmn54u 57 2 of of IN work_7k7caouvh5efzjp7ikemnmn54u 57 3 where where WRB work_7k7caouvh5efzjp7ikemnmn54u 57 4 each each DT work_7k7caouvh5efzjp7ikemnmn54u 57 5 hydrogen hydrogen NN work_7k7caouvh5efzjp7ikemnmn54u 57 6 bond bond NN work_7k7caouvh5efzjp7ikemnmn54u 57 7 does do VBZ work_7k7caouvh5efzjp7ikemnmn54u 57 8 actually actually RB work_7k7caouvh5efzjp7ikemnmn54u 57 9 break break VB work_7k7caouvh5efzjp7ikemnmn54u 57 10 in in IN work_7k7caouvh5efzjp7ikemnmn54u 57 11 the the DT work_7k7caouvh5efzjp7ikemnmn54u 57 12 rate- rate- NN work_7k7caouvh5efzjp7ikemnmn54u 57 13 limiting limit VBG work_7k7caouvh5efzjp7ikemnmn54u 57 14 step step NN work_7k7caouvh5efzjp7ikemnmn54u 57 15 of of IN work_7k7caouvh5efzjp7ikemnmn54u 57 16 unfolding unfolding NN work_7k7caouvh5efzjp7ikemnmn54u 57 17 , , , work_7k7caouvh5efzjp7ikemnmn54u 57 18 it -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 57 19 will will MD work_7k7caouvh5efzjp7ikemnmn54u 57 20 be be VB work_7k7caouvh5efzjp7ikemnmn54u 57 21 decaying decay VBG work_7k7caouvh5efzjp7ikemnmn54u 57 22 with with IN work_7k7caouvh5efzjp7ikemnmn54u 57 23 the the DT work_7k7caouvh5efzjp7ikemnmn54u 57 24 same same JJ work_7k7caouvh5efzjp7ikemnmn54u 57 25 kinetic kinetic JJ work_7k7caouvh5efzjp7ikemnmn54u 57 26 exponent exponent NN work_7k7caouvh5efzjp7ikemnmn54u 57 27 . . . work_7k7caouvh5efzjp7ikemnmn54u 58 1 Currently currently RB work_7k7caouvh5efzjp7ikemnmn54u 58 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 58 3 in in IN work_7k7caouvh5efzjp7ikemnmn54u 58 4 fact fact NN work_7k7caouvh5efzjp7ikemnmn54u 58 5 , , , work_7k7caouvh5efzjp7ikemnmn54u 58 6 only only RB work_7k7caouvh5efzjp7ikemnmn54u 58 7 the the DT work_7k7caouvh5efzjp7ikemnmn54u 58 8 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 58 9 engineering engineering NN work_7k7caouvh5efzjp7ikemnmn54u 58 10 method method NN work_7k7caouvh5efzjp7ikemnmn54u 58 11 can can MD work_7k7caouvh5efzjp7ikemnmn54u 58 12 provide provide VB work_7k7caouvh5efzjp7ikemnmn54u 58 13 information information NN work_7k7caouvh5efzjp7ikemnmn54u 58 14 about about IN work_7k7caouvh5efzjp7ikemnmn54u 58 15 the the DT work_7k7caouvh5efzjp7ikemnmn54u 58 16 structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 58 17 of of IN work_7k7caouvh5efzjp7ikemnmn54u 58 18 the the DT work_7k7caouvh5efzjp7ikemnmn54u 58 19 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 58 20 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 58 21 state state NN work_7k7caouvh5efzjp7ikemnmn54u 58 22 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 58 23 30 30 CD work_7k7caouvh5efzjp7ikemnmn54u 58 24 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 58 25 . . . work_7k7caouvh5efzjp7ikemnmn54u 59 1 Keeping keep VBG work_7k7caouvh5efzjp7ikemnmn54u 59 2 that that IN work_7k7caouvh5efzjp7ikemnmn54u 59 3 in in IN work_7k7caouvh5efzjp7ikemnmn54u 59 4 mind mind NN work_7k7caouvh5efzjp7ikemnmn54u 59 5 , , , work_7k7caouvh5efzjp7ikemnmn54u 59 6 let let VB work_7k7caouvh5efzjp7ikemnmn54u 59 7 me -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 59 8 turn turn VB work_7k7caouvh5efzjp7ikemnmn54u 59 9 to to IN work_7k7caouvh5efzjp7ikemnmn54u 59 10 the the DT work_7k7caouvh5efzjp7ikemnmn54u 59 11 analysis analysis NN work_7k7caouvh5efzjp7ikemnmn54u 59 12 of of IN work_7k7caouvh5efzjp7ikemnmn54u 59 13 experiments experiment NNS work_7k7caouvh5efzjp7ikemnmn54u 59 14 that that WDT work_7k7caouvh5efzjp7ikemnmn54u 59 15 aim aim VBP work_7k7caouvh5efzjp7ikemnmn54u 59 16 specifically specifically RB work_7k7caouvh5efzjp7ikemnmn54u 59 17 to to TO work_7k7caouvh5efzjp7ikemnmn54u 59 18 study study VB work_7k7caouvh5efzjp7ikemnmn54u 59 19 the the DT work_7k7caouvh5efzjp7ikemnmn54u 59 20 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 59 21 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 59 22 state state NN work_7k7caouvh5efzjp7ikemnmn54u 59 23 . . . work_7k7caouvh5efzjp7ikemnmn54u 60 1 These these DT work_7k7caouvh5efzjp7ikemnmn54u 60 2 clearly clearly RB work_7k7caouvh5efzjp7ikemnmn54u 60 3 point point VBP work_7k7caouvh5efzjp7ikemnmn54u 60 4 out out RP work_7k7caouvh5efzjp7ikemnmn54u 60 5 that that IN work_7k7caouvh5efzjp7ikemnmn54u 60 6 the the DT work_7k7caouvh5efzjp7ikemnmn54u 60 7 hydrogen hydrogen NNP work_7k7caouvh5efzjp7ikemnmn54u 60 8 bond bond NN work_7k7caouvh5efzjp7ikemnmn54u 60 9 network network NN work_7k7caouvh5efzjp7ikemnmn54u 60 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 60 11 or or CC work_7k7caouvh5efzjp7ikemnmn54u 60 12 secondary secondary JJ work_7k7caouvh5efzjp7ikemnmn54u 60 13 structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 60 14 , , , work_7k7caouvh5efzjp7ikemnmn54u 60 15 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 60 16 formed form VBN work_7k7caouvh5efzjp7ikemnmn54u 60 17 after after IN work_7k7caouvh5efzjp7ikemnmn54u 60 18 the the DT work_7k7caouvh5efzjp7ikemnmn54u 60 19 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 60 20 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 60 21 state state NN work_7k7caouvh5efzjp7ikemnmn54u 60 22 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 60 23 overcome overcome VBN work_7k7caouvh5efzjp7ikemnmn54u 60 24 . . . work_7k7caouvh5efzjp7ikemnmn54u 61 1 First first RB work_7k7caouvh5efzjp7ikemnmn54u 61 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 61 3 consider consider VB work_7k7caouvh5efzjp7ikemnmn54u 61 4 a a DT work_7k7caouvh5efzjp7ikemnmn54u 61 5 series series NN work_7k7caouvh5efzjp7ikemnmn54u 61 6 of of IN work_7k7caouvh5efzjp7ikemnmn54u 61 7 conclusive conclusive JJ work_7k7caouvh5efzjp7ikemnmn54u 61 8 experiments experiment NNS work_7k7caouvh5efzjp7ikemnmn54u 61 9 by by IN work_7k7caouvh5efzjp7ikemnmn54u 61 10 Fersht Fersht NNS work_7k7caouvh5efzjp7ikemnmn54u 61 11 and and CC work_7k7caouvh5efzjp7ikemnmn54u 61 12 co co NNS work_7k7caouvh5efzjp7ikemnmn54u 61 13 - - NNS work_7k7caouvh5efzjp7ikemnmn54u 61 14 workers worker NNS work_7k7caouvh5efzjp7ikemnmn54u 61 15 on on IN work_7k7caouvh5efzjp7ikemnmn54u 61 16 CI2 CI2 NNP work_7k7caouvh5efzjp7ikemnmn54u 61 17 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 61 18 31,32 31,32 CD work_7k7caouvh5efzjp7ikemnmn54u 61 19 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 61 20 . . . work_7k7caouvh5efzjp7ikemnmn54u 62 1 They -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 62 2 provide provide VBP work_7k7caouvh5efzjp7ikemnmn54u 62 3 extensive extensive JJ work_7k7caouvh5efzjp7ikemnmn54u 62 4 data datum NNS work_7k7caouvh5efzjp7ikemnmn54u 62 5 suggesting suggest VBG work_7k7caouvh5efzjp7ikemnmn54u 62 6 that that IN work_7k7caouvh5efzjp7ikemnmn54u 62 7 mutations mutation NNS work_7k7caouvh5efzjp7ikemnmn54u 62 8 outside outside IN work_7k7caouvh5efzjp7ikemnmn54u 62 9 the the DT work_7k7caouvh5efzjp7ikemnmn54u 62 10 nucleation nucleation NN work_7k7caouvh5efzjp7ikemnmn54u 62 11 core core NN work_7k7caouvh5efzjp7ikemnmn54u 62 12 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 62 13 but but CC work_7k7caouvh5efzjp7ikemnmn54u 62 14 affecting affect VBG work_7k7caouvh5efzjp7ikemnmn54u 62 15 the the DT work_7k7caouvh5efzjp7ikemnmn54u 62 16 stability stability NN work_7k7caouvh5efzjp7ikemnmn54u 62 17 of of IN work_7k7caouvh5efzjp7ikemnmn54u 62 18 secondary secondary JJ work_7k7caouvh5efzjp7ikemnmn54u 62 19 structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 62 20 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 62 21 do do VBP work_7k7caouvh5efzjp7ikemnmn54u 62 22 not not RB work_7k7caouvh5efzjp7ikemnmn54u 62 23 signif- signif- VB work_7k7caouvh5efzjp7ikemnmn54u 62 24 icantly icantly RB work_7k7caouvh5efzjp7ikemnmn54u 62 25 affect affect VB work_7k7caouvh5efzjp7ikemnmn54u 62 26 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 62 27 kinetics kinetic NNS work_7k7caouvh5efzjp7ikemnmn54u 62 28 . . . work_7k7caouvh5efzjp7ikemnmn54u 63 1 A a DT work_7k7caouvh5efzjp7ikemnmn54u 63 2 good good JJ work_7k7caouvh5efzjp7ikemnmn54u 63 3 example example NN work_7k7caouvh5efzjp7ikemnmn54u 63 4 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 63 5 Val19→Ala Val19→Ala NNP work_7k7caouvh5efzjp7ikemnmn54u 63 6 substitution substitution NN work_7k7caouvh5efzjp7ikemnmn54u 63 7 in in IN work_7k7caouvh5efzjp7ikemnmn54u 63 8 CI2 CI2 NNP work_7k7caouvh5efzjp7ikemnmn54u 63 9 . . . work_7k7caouvh5efzjp7ikemnmn54u 64 1 Mutation mutation NN work_7k7caouvh5efzjp7ikemnmn54u 64 2 of of IN work_7k7caouvh5efzjp7ikemnmn54u 64 3 two two CD work_7k7caouvh5efzjp7ikemnmn54u 64 4 neighbor- neighbor- NN work_7k7caouvh5efzjp7ikemnmn54u 64 5 ing ing JJ work_7k7caouvh5efzjp7ikemnmn54u 64 6 core core NN work_7k7caouvh5efzjp7ikemnmn54u 64 7 residues residue NNS work_7k7caouvh5efzjp7ikemnmn54u 64 8 belonging belong VBG work_7k7caouvh5efzjp7ikemnmn54u 64 9 to to IN work_7k7caouvh5efzjp7ikemnmn54u 64 10 the the DT work_7k7caouvh5efzjp7ikemnmn54u 64 11 same same JJ work_7k7caouvh5efzjp7ikemnmn54u 64 12 � � NNP work_7k7caouvh5efzjp7ikemnmn54u 64 13 -helix -helix JJ work_7k7caouvh5efzjp7ikemnmn54u 64 14 , , , work_7k7caouvh5efzjp7ikemnmn54u 64 15 Ala16 Ala16 NNP work_7k7caouvh5efzjp7ikemnmn54u 64 16 and and CC work_7k7caouvh5efzjp7ikemnmn54u 64 17 Ile20 Ile20 NNP work_7k7caouvh5efzjp7ikemnmn54u 64 18 , , , work_7k7caouvh5efzjp7ikemnmn54u 64 19 strongly strongly RB work_7k7caouvh5efzjp7ikemnmn54u 64 20 affect affect VB work_7k7caouvh5efzjp7ikemnmn54u 64 21 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 64 22 kinetics kinetic NNS work_7k7caouvh5efzjp7ikemnmn54u 64 23 having have VBG work_7k7caouvh5efzjp7ikemnmn54u 64 24 � � NNP work_7k7caouvh5efzjp7ikemnmn54u 64 25 -values -values , work_7k7caouvh5efzjp7ikemnmn54u 64 26 of of IN work_7k7caouvh5efzjp7ikemnmn54u 64 27 1.0 1.0 CD work_7k7caouvh5efzjp7ikemnmn54u 64 28 and and CC work_7k7caouvh5efzjp7ikemnmn54u 64 29 0.48 0.48 CD work_7k7caouvh5efzjp7ikemnmn54u 64 30 respectively respectively RB work_7k7caouvh5efzjp7ikemnmn54u 64 31 . . . work_7k7caouvh5efzjp7ikemnmn54u 65 1 Val19 Val19 NNP work_7k7caouvh5efzjp7ikemnmn54u 65 2 does do VBZ work_7k7caouvh5efzjp7ikemnmn54u 65 3 not not RB work_7k7caouvh5efzjp7ikemnmn54u 65 4 participate participate VB work_7k7caouvh5efzjp7ikemnmn54u 65 5 in in IN work_7k7caouvh5efzjp7ikemnmn54u 65 6 the the DT work_7k7caouvh5efzjp7ikemnmn54u 65 7 core core NN work_7k7caouvh5efzjp7ikemnmn54u 65 8 but but CC work_7k7caouvh5efzjp7ikemnmn54u 65 9 belongs belong VBZ work_7k7caouvh5efzjp7ikemnmn54u 65 10 to to IN work_7k7caouvh5efzjp7ikemnmn54u 65 11 the the DT work_7k7caouvh5efzjp7ikemnmn54u 65 12 � � NNP work_7k7caouvh5efzjp7ikemnmn54u 65 13 -helix -helix NN work_7k7caouvh5efzjp7ikemnmn54u 65 14 . . . work_7k7caouvh5efzjp7ikemnmn54u 66 1 Its -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 66 2 mutation mutation NN work_7k7caouvh5efzjp7ikemnmn54u 66 3 to to TO work_7k7caouvh5efzjp7ikemnmn54u 66 4 alanine alanine VB work_7k7caouvh5efzjp7ikemnmn54u 66 5 stabilizes stabilize VBZ work_7k7caouvh5efzjp7ikemnmn54u 66 6 the the DT work_7k7caouvh5efzjp7ikemnmn54u 66 7 helix helix NNP work_7k7caouvh5efzjp7ikemnmn54u 66 8 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 66 9 33 33 CD work_7k7caouvh5efzjp7ikemnmn54u 66 10 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 66 11 , , , work_7k7caouvh5efzjp7ikemnmn54u 66 12 but but CC work_7k7caouvh5efzjp7ikemnmn54u 66 13 leads lead VBZ work_7k7caouvh5efzjp7ikemnmn54u 66 14 to to IN work_7k7caouvh5efzjp7ikemnmn54u 66 15 only only RB work_7k7caouvh5efzjp7ikemnmn54u 66 16 a a DT work_7k7caouvh5efzjp7ikemnmn54u 66 17 3 3 CD work_7k7caouvh5efzjp7ikemnmn54u 66 18 % % NN work_7k7caouvh5efzjp7ikemnmn54u 66 19 increase increase NN work_7k7caouvh5efzjp7ikemnmn54u 66 20 of of IN work_7k7caouvh5efzjp7ikemnmn54u 66 21 the the DT work_7k7caouvh5efzjp7ikemnmn54u 66 22 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 66 23 rate rate NN work_7k7caouvh5efzjp7ikemnmn54u 66 24 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 66 25 practically practically RB work_7k7caouvh5efzjp7ikemnmn54u 66 26 within within IN work_7k7caouvh5efzjp7ikemnmn54u 66 27 experimental experimental JJ work_7k7caouvh5efzjp7ikemnmn54u 66 28 error error NN work_7k7caouvh5efzjp7ikemnmn54u 66 29 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 66 30 . . . work_7k7caouvh5efzjp7ikemnmn54u 67 1 Normalized normalized JJ work_7k7caouvh5efzjp7ikemnmn54u 67 2 to to IN work_7k7caouvh5efzjp7ikemnmn54u 67 3 a a DT work_7k7caouvh5efzjp7ikemnmn54u 67 4 small small JJ work_7k7caouvh5efzjp7ikemnmn54u 67 5 stability stability NN work_7k7caouvh5efzjp7ikemnmn54u 67 6 change change NN work_7k7caouvh5efzjp7ikemnmn54u 67 7 , , , work_7k7caouvh5efzjp7ikemnmn54u 67 8 it -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 67 9 yields yield VBZ work_7k7caouvh5efzjp7ikemnmn54u 67 10 a a DT work_7k7caouvh5efzjp7ikemnmn54u 67 11 � � NNP work_7k7caouvh5efzjp7ikemnmn54u 67 12 -value -value NN work_7k7caouvh5efzjp7ikemnmn54u 67 13 of of IN work_7k7caouvh5efzjp7ikemnmn54u 67 14 – – : work_7k7caouvh5efzjp7ikemnmn54u 67 15 0.15 0.15 CD work_7k7caouvh5efzjp7ikemnmn54u 67 16 for for IN work_7k7caouvh5efzjp7ikemnmn54u 67 17 Val19 Val19 NNP work_7k7caouvh5efzjp7ikemnmn54u 67 18 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 67 19 31,32 31,32 CD work_7k7caouvh5efzjp7ikemnmn54u 67 20 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 67 21 . . . work_7k7caouvh5efzjp7ikemnmn54u 68 1 This this DT work_7k7caouvh5efzjp7ikemnmn54u 68 2 shows show VBZ work_7k7caouvh5efzjp7ikemnmn54u 68 3 clearly clearly RB work_7k7caouvh5efzjp7ikemnmn54u 68 4 that that IN work_7k7caouvh5efzjp7ikemnmn54u 68 5 the the DT work_7k7caouvh5efzjp7ikemnmn54u 68 6 con- con- NN work_7k7caouvh5efzjp7ikemnmn54u 68 7 tribution tribution NN work_7k7caouvh5efzjp7ikemnmn54u 68 8 of of IN work_7k7caouvh5efzjp7ikemnmn54u 68 9 formation formation NN work_7k7caouvh5efzjp7ikemnmn54u 68 10 of of IN work_7k7caouvh5efzjp7ikemnmn54u 68 11 transient transient JJ work_7k7caouvh5efzjp7ikemnmn54u 68 12 fragments fragment NNS work_7k7caouvh5efzjp7ikemnmn54u 68 13 of of IN work_7k7caouvh5efzjp7ikemnmn54u 68 14 secondary secondary JJ work_7k7caouvh5efzjp7ikemnmn54u 68 15 structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 68 16 to to IN work_7k7caouvh5efzjp7ikemnmn54u 68 17 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 68 18 rate rate NN work_7k7caouvh5efzjp7ikemnmn54u 68 19 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 68 20 a a DT work_7k7caouvh5efzjp7ikemnmn54u 68 21 few few JJ work_7k7caouvh5efzjp7ikemnmn54u 68 22 percent percent NN work_7k7caouvh5efzjp7ikemnmn54u 68 23 . . . work_7k7caouvh5efzjp7ikemnmn54u 69 1 The the DT work_7k7caouvh5efzjp7ikemnmn54u 69 2 conclusive conclusive JJ work_7k7caouvh5efzjp7ikemnmn54u 69 3 result result NN work_7k7caouvh5efzjp7ikemnmn54u 69 4 of of IN work_7k7caouvh5efzjp7ikemnmn54u 69 5 simulations simulation NNS work_7k7caouvh5efzjp7ikemnmn54u 69 6 and and CC work_7k7caouvh5efzjp7ikemnmn54u 69 7 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 69 8 engineer- engineer- NN work_7k7caouvh5efzjp7ikemnmn54u 69 9 ing e VBG work_7k7caouvh5efzjp7ikemnmn54u 69 10 experiments experiment NNS work_7k7caouvh5efzjp7ikemnmn54u 69 11 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 69 12 that that IN work_7k7caouvh5efzjp7ikemnmn54u 69 13 the the DT work_7k7caouvh5efzjp7ikemnmn54u 69 14 major major JJ work_7k7caouvh5efzjp7ikemnmn54u 69 15 factors factor NNS work_7k7caouvh5efzjp7ikemnmn54u 69 16 determining determine VBG work_7k7caouvh5efzjp7ikemnmn54u 69 17 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 69 18 kinetics kinetic NNS work_7k7caouvh5efzjp7ikemnmn54u 69 19 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 69 20 long long JJ work_7k7caouvh5efzjp7ikemnmn54u 69 21 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 69 22 range range NN work_7k7caouvh5efzjp7ikemnmn54u 69 23 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 69 24 in in IN work_7k7caouvh5efzjp7ikemnmn54u 69 25 sequence sequence NN work_7k7caouvh5efzjp7ikemnmn54u 69 26 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 69 27 interactions interaction NNS work_7k7caouvh5efzjp7ikemnmn54u 69 28 forming form VBG work_7k7caouvh5efzjp7ikemnmn54u 69 29 the the DT work_7k7caouvh5efzjp7ikemnmn54u 69 30 nucleus nucleus NN work_7k7caouvh5efzjp7ikemnmn54u 69 31 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 69 32 10,32 10,32 CD work_7k7caouvh5efzjp7ikemnmn54u 69 33 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 69 34 . . . work_7k7caouvh5efzjp7ikemnmn54u 70 1 These these DT work_7k7caouvh5efzjp7ikemnmn54u 70 2 results result NNS work_7k7caouvh5efzjp7ikemnmn54u 70 3 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 70 4 corrobo- corrobo- RB work_7k7caouvh5efzjp7ikemnmn54u 70 5 rated rate VBN work_7k7caouvh5efzjp7ikemnmn54u 70 6 in in IN work_7k7caouvh5efzjp7ikemnmn54u 70 7 the the DT work_7k7caouvh5efzjp7ikemnmn54u 70 8 work work NN work_7k7caouvh5efzjp7ikemnmn54u 70 9 of of IN work_7k7caouvh5efzjp7ikemnmn54u 70 10 Sauer Sauer NNP work_7k7caouvh5efzjp7ikemnmn54u 70 11 and and CC work_7k7caouvh5efzjp7ikemnmn54u 70 12 co co NNS work_7k7caouvh5efzjp7ikemnmn54u 70 13 - - NNS work_7k7caouvh5efzjp7ikemnmn54u 70 14 workers worker NNS work_7k7caouvh5efzjp7ikemnmn54u 70 15 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 70 16 34 34 CD work_7k7caouvh5efzjp7ikemnmn54u 70 17 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 70 18 with with IN work_7k7caouvh5efzjp7ikemnmn54u 70 19 another another DT work_7k7caouvh5efzjp7ikemnmn54u 70 20 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 70 21 , , , work_7k7caouvh5efzjp7ikemnmn54u 70 22 P22 P22 NNP work_7k7caouvh5efzjp7ikemnmn54u 70 23 arc arc NN work_7k7caouvh5efzjp7ikemnmn54u 70 24 repressor repressor NN work_7k7caouvh5efzjp7ikemnmn54u 70 25 . . . work_7k7caouvh5efzjp7ikemnmn54u 71 1 Mutation Mutation NNP work_7k7caouvh5efzjp7ikemnmn54u 71 2 Pro8→Leu Pro8→Leu NNP work_7k7caouvh5efzjp7ikemnmn54u 71 3 increased increase VBD work_7k7caouvh5efzjp7ikemnmn54u 71 4 the the DT work_7k7caouvh5efzjp7ikemnmn54u 71 5 stability stability NN work_7k7caouvh5efzjp7ikemnmn54u 71 6 of of IN work_7k7caouvh5efzjp7ikemnmn54u 71 7 the the DT work_7k7caouvh5efzjp7ikemnmn54u 71 8 � � NNP work_7k7caouvh5efzjp7ikemnmn54u 71 9 -sheet -sheet NNP work_7k7caouvh5efzjp7ikemnmn54u 71 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 71 11 but but CC work_7k7caouvh5efzjp7ikemnmn54u 71 12 the the DT work_7k7caouvh5efzjp7ikemnmn54u 71 13 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 71 14 rate rate NN work_7k7caouvh5efzjp7ikemnmn54u 71 15 remained remain VBD work_7k7caouvh5efzjp7ikemnmn54u 71 16 largely largely RB work_7k7caouvh5efzjp7ikemnmn54u 71 17 unchanged unchanged JJ work_7k7caouvh5efzjp7ikemnmn54u 71 18 . . . work_7k7caouvh5efzjp7ikemnmn54u 72 1 The the DT work_7k7caouvh5efzjp7ikemnmn54u 72 2 conclusion conclusion NN work_7k7caouvh5efzjp7ikemnmn54u 72 3 was be VBD work_7k7caouvh5efzjp7ikemnmn54u 72 4 made make VBN work_7k7caouvh5efzjp7ikemnmn54u 72 5 in in IN work_7k7caouvh5efzjp7ikemnmn54u 72 6 this this DT work_7k7caouvh5efzjp7ikemnmn54u 72 7 work work NN work_7k7caouvh5efzjp7ikemnmn54u 72 8 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 72 9 34 34 CD work_7k7caouvh5efzjp7ikemnmn54u 72 10 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 72 11 that that IN work_7k7caouvh5efzjp7ikemnmn54u 72 12 “ " `` work_7k7caouvh5efzjp7ikemnmn54u 72 13 the the DT work_7k7caouvh5efzjp7ikemnmn54u 72 14 � � NNP work_7k7caouvh5efzjp7ikemnmn54u 72 15 -sheet -sheet JJ work_7k7caouvh5efzjp7ikemnmn54u 72 16 forms form NNS work_7k7caouvh5efzjp7ikemnmn54u 72 17 after after IN work_7k7caouvh5efzjp7ikemnmn54u 72 18 the the DT work_7k7caouvh5efzjp7ikemnmn54u 72 19 rate rate NN work_7k7caouvh5efzjp7ikemnmn54u 72 20 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 72 21 limit- limit- NN work_7k7caouvh5efzjp7ikemnmn54u 72 22 ing ing NN work_7k7caouvh5efzjp7ikemnmn54u 72 23 state state NN work_7k7caouvh5efzjp7ikemnmn54u 72 24 in in IN work_7k7caouvh5efzjp7ikemnmn54u 72 25 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 72 26 . . . work_7k7caouvh5efzjp7ikemnmn54u 72 27 ” " '' work_7k7caouvh5efzjp7ikemnmn54u 72 28 Subsequent subsequent JJ work_7k7caouvh5efzjp7ikemnmn54u 72 29 study study NN work_7k7caouvh5efzjp7ikemnmn54u 72 30 from from IN work_7k7caouvh5efzjp7ikemnmn54u 72 31 the the DT work_7k7caouvh5efzjp7ikemnmn54u 72 32 same same JJ work_7k7caouvh5efzjp7ikemnmn54u 72 33 lab- lab- NN work_7k7caouvh5efzjp7ikemnmn54u 72 34 oratory oratory NN work_7k7caouvh5efzjp7ikemnmn54u 72 35 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 72 36 35 35 CD work_7k7caouvh5efzjp7ikemnmn54u 72 37 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 72 38 included include VBN work_7k7caouvh5efzjp7ikemnmn54u 72 39 substitution substitution NN work_7k7caouvh5efzjp7ikemnmn54u 72 40 of of IN work_7k7caouvh5efzjp7ikemnmn54u 72 41 many many JJ work_7k7caouvh5efzjp7ikemnmn54u 72 42 helical helical JJ work_7k7caouvh5efzjp7ikemnmn54u 72 43 sites site NNS work_7k7caouvh5efzjp7ikemnmn54u 72 44 in in IN work_7k7caouvh5efzjp7ikemnmn54u 72 45 the the DT work_7k7caouvh5efzjp7ikemnmn54u 72 46 P22 P22 NNP work_7k7caouvh5efzjp7ikemnmn54u 72 47 arc arc NN work_7k7caouvh5efzjp7ikemnmn54u 72 48 repressor repressor NN work_7k7caouvh5efzjp7ikemnmn54u 72 49 by by IN work_7k7caouvh5efzjp7ikemnmn54u 72 50 helix helix NN work_7k7caouvh5efzjp7ikemnmn54u 72 51 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 72 52 propensity propensity NN work_7k7caouvh5efzjp7ikemnmn54u 72 53 altering alter VBG work_7k7caouvh5efzjp7ikemnmn54u 72 54 alanine alanine NN work_7k7caouvh5efzjp7ikemnmn54u 72 55 with with IN work_7k7caouvh5efzjp7ikemnmn54u 72 56 little little JJ work_7k7caouvh5efzjp7ikemnmn54u 72 57 change change NN work_7k7caouvh5efzjp7ikemnmn54u 72 58 in in IN work_7k7caouvh5efzjp7ikemnmn54u 72 59 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 72 60 rates rate NNS work_7k7caouvh5efzjp7ikemnmn54u 72 61 also also RB work_7k7caouvh5efzjp7ikemnmn54u 72 62 . . . work_7k7caouvh5efzjp7ikemnmn54u 73 1 Similar similar JJ work_7k7caouvh5efzjp7ikemnmn54u 73 2 results result NNS work_7k7caouvh5efzjp7ikemnmn54u 73 3 were be VBD work_7k7caouvh5efzjp7ikemnmn54u 73 4 obtained obtain VBN work_7k7caouvh5efzjp7ikemnmn54u 73 5 recently recently RB work_7k7caouvh5efzjp7ikemnmn54u 73 6 for for IN work_7k7caouvh5efzjp7ikemnmn54u 73 7 another another DT work_7k7caouvh5efzjp7ikemnmn54u 73 8 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 73 9 , , , work_7k7caouvh5efzjp7ikemnmn54u 73 10 CheY chey NN work_7k7caouvh5efzjp7ikemnmn54u 73 11 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 73 12 36 36 CD work_7k7caouvh5efzjp7ikemnmn54u 73 13 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 73 14 . . . work_7k7caouvh5efzjp7ikemnmn54u 74 1 For for IN work_7k7caouvh5efzjp7ikemnmn54u 74 2 example example NN work_7k7caouvh5efzjp7ikemnmn54u 74 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 74 4 mutation mutation NN work_7k7caouvh5efzjp7ikemnmn54u 74 5 Gly39→Ala Gly39→Ala NNP work_7k7caouvh5efzjp7ikemnmn54u 74 6 in in IN work_7k7caouvh5efzjp7ikemnmn54u 74 7 this this DT work_7k7caouvh5efzjp7ikemnmn54u 74 8 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 74 9 stabilizes stabilize VBZ work_7k7caouvh5efzjp7ikemnmn54u 74 10 � � NNS work_7k7caouvh5efzjp7ikemnmn54u 74 11 -helix -helix VBD work_7k7caouvh5efzjp7ikemnmn54u 74 12 2 2 CD work_7k7caouvh5efzjp7ikemnmn54u 74 13 but but CC work_7k7caouvh5efzjp7ikemnmn54u 74 14 does do VBZ work_7k7caouvh5efzjp7ikemnmn54u 74 15 not not RB work_7k7caouvh5efzjp7ikemnmn54u 74 16 affect affect VB work_7k7caouvh5efzjp7ikemnmn54u 74 17 the the DT work_7k7caouvh5efzjp7ikemnmn54u 74 18 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 74 19 rate rate NN work_7k7caouvh5efzjp7ikemnmn54u 74 20 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 74 21 � � NN work_7k7caouvh5efzjp7ikemnmn54u 74 22 -value -value NN work_7k7caouvh5efzjp7ikemnmn54u 74 23 for for IN work_7k7caouvh5efzjp7ikemnmn54u 74 24 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 74 25 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 74 26 0.03 0.03 CD work_7k7caouvh5efzjp7ikemnmn54u 74 27 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 74 28 . . . work_7k7caouvh5efzjp7ikemnmn54u 75 1 Mutational mutational JJ work_7k7caouvh5efzjp7ikemnmn54u 75 2 analysis analysis NN work_7k7caouvh5efzjp7ikemnmn54u 75 3 was be VBD work_7k7caouvh5efzjp7ikemnmn54u 75 4 also also RB work_7k7caouvh5efzjp7ikemnmn54u 75 5 employed employ VBN work_7k7caouvh5efzjp7ikemnmn54u 75 6 by by IN work_7k7caouvh5efzjp7ikemnmn54u 75 7 Sosnick Sosnick NNP work_7k7caouvh5efzjp7ikemnmn54u 75 8 et et NNP work_7k7caouvh5efzjp7ikemnmn54u 75 9 al al NNP work_7k7caouvh5efzjp7ikemnmn54u 75 10 . . . work_7k7caouvh5efzjp7ikemnmn54u 76 1 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 76 2 37 37 CD work_7k7caouvh5efzjp7ikemnmn54u 76 3 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 76 4 to to TO work_7k7caouvh5efzjp7ikemnmn54u 76 5 determine determine VB work_7k7caouvh5efzjp7ikemnmn54u 76 6 when when WRB work_7k7caouvh5efzjp7ikemnmn54u 76 7 secondary secondary JJ work_7k7caouvh5efzjp7ikemnmn54u 76 8 structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 76 9 forms form NNS work_7k7caouvh5efzjp7ikemnmn54u 76 10 in in IN work_7k7caouvh5efzjp7ikemnmn54u 76 11 the the DT work_7k7caouvh5efzjp7ikemnmn54u 76 12 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 76 13 of of IN work_7k7caouvh5efzjp7ikemnmn54u 76 14 an an DT work_7k7caouvh5efzjp7ikemnmn54u 76 15 � � JJ work_7k7caouvh5efzjp7ikemnmn54u 76 16 -helical -helical JJ work_7k7caouvh5efzjp7ikemnmn54u 76 17 dimer dimer NN work_7k7caouvh5efzjp7ikemnmn54u 76 18 , , , work_7k7caouvh5efzjp7ikemnmn54u 76 19 GCN4 GCN4 NNP work_7k7caouvh5efzjp7ikemnmn54u 76 20 . . . work_7k7caouvh5efzjp7ikemnmn54u 77 1 Residues residue NNS work_7k7caouvh5efzjp7ikemnmn54u 77 2 at at IN work_7k7caouvh5efzjp7ikemnmn54u 77 3 non non JJ work_7k7caouvh5efzjp7ikemnmn54u 77 4 - - JJ work_7k7caouvh5efzjp7ikemnmn54u 77 5 per- per- JJ work_7k7caouvh5efzjp7ikemnmn54u 77 6 Review Review NNP work_7k7caouvh5efzjp7ikemnmn54u 77 7 Modeling Modeling NNP work_7k7caouvh5efzjp7ikemnmn54u 77 8 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 77 9 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 77 10 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 77 11 R51 R51 NNP work_7k7caouvh5efzjp7ikemnmn54u 77 12 R52 R52 NNP work_7k7caouvh5efzjp7ikemnmn54u 77 13 Folding Folding NNP work_7k7caouvh5efzjp7ikemnmn54u 77 14 & & CC work_7k7caouvh5efzjp7ikemnmn54u 77 15 Design Design NNP work_7k7caouvh5efzjp7ikemnmn54u 77 16 Vol Vol NNP work_7k7caouvh5efzjp7ikemnmn54u 77 17 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 77 18 No no DT work_7k7caouvh5efzjp7ikemnmn54u 77 19 3 3 CD work_7k7caouvh5efzjp7ikemnmn54u 77 20 turbing turbe VBG work_7k7caouvh5efzjp7ikemnmn54u 77 21 positions position NNS work_7k7caouvh5efzjp7ikemnmn54u 77 22 along along IN work_7k7caouvh5efzjp7ikemnmn54u 77 23 the the DT work_7k7caouvh5efzjp7ikemnmn54u 77 24 exterior exterior JJ work_7k7caouvh5efzjp7ikemnmn54u 77 25 length length NN work_7k7caouvh5efzjp7ikemnmn54u 77 26 of of IN work_7k7caouvh5efzjp7ikemnmn54u 77 27 the the DT work_7k7caouvh5efzjp7ikemnmn54u 77 28 helices helix NNS work_7k7caouvh5efzjp7ikemnmn54u 77 29 were be VBD work_7k7caouvh5efzjp7ikemnmn54u 77 30 substituted substitute VBN work_7k7caouvh5efzjp7ikemnmn54u 77 31 one one CD work_7k7caouvh5efzjp7ikemnmn54u 77 32 at at IN work_7k7caouvh5efzjp7ikemnmn54u 77 33 a a DT work_7k7caouvh5efzjp7ikemnmn54u 77 34 time time NN work_7k7caouvh5efzjp7ikemnmn54u 77 35 with with IN work_7k7caouvh5efzjp7ikemnmn54u 77 36 alanine alanine NN work_7k7caouvh5efzjp7ikemnmn54u 77 37 and and CC work_7k7caouvh5efzjp7ikemnmn54u 77 38 glycine glycine NN work_7k7caouvh5efzjp7ikemnmn54u 77 39 to to TO work_7k7caouvh5efzjp7ikemnmn54u 77 40 vary vary VB work_7k7caouvh5efzjp7ikemnmn54u 77 41 helix helix JJ work_7k7caouvh5efzjp7ikemnmn54u 77 42 propensity propensity NN work_7k7caouvh5efzjp7ikemnmn54u 77 43 . . . work_7k7caouvh5efzjp7ikemnmn54u 78 1 For for IN work_7k7caouvh5efzjp7ikemnmn54u 78 2 all all DT work_7k7caouvh5efzjp7ikemnmn54u 78 3 variants variant NNS work_7k7caouvh5efzjp7ikemnmn54u 78 4 the the DT work_7k7caouvh5efzjp7ikemnmn54u 78 5 bimolecular bimolecular JJ work_7k7caouvh5efzjp7ikemnmn54u 78 6 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 78 7 rate rate NN work_7k7caouvh5efzjp7ikemnmn54u 78 8 remains remain VBZ work_7k7caouvh5efzjp7ikemnmn54u 78 9 largely largely RB work_7k7caouvh5efzjp7ikemnmn54u 78 10 unchanged unchanged JJ work_7k7caouvh5efzjp7ikemnmn54u 78 11 ; ; : work_7k7caouvh5efzjp7ikemnmn54u 78 12 the the DT work_7k7caouvh5efzjp7ikemnmn54u 78 13 change change NN work_7k7caouvh5efzjp7ikemnmn54u 78 14 in in IN work_7k7caouvh5efzjp7ikemnmn54u 78 15 sta- sta- JJ work_7k7caouvh5efzjp7ikemnmn54u 78 16 bility bility NN work_7k7caouvh5efzjp7ikemnmn54u 78 17 appears appear VBZ work_7k7caouvh5efzjp7ikemnmn54u 78 18 largely largely RB work_7k7caouvh5efzjp7ikemnmn54u 78 19 in in IN work_7k7caouvh5efzjp7ikemnmn54u 78 20 the the DT work_7k7caouvh5efzjp7ikemnmn54u 78 21 unfolding unfold VBG work_7k7caouvh5efzjp7ikemnmn54u 78 22 rate rate NN work_7k7caouvh5efzjp7ikemnmn54u 78 23 . . . work_7k7caouvh5efzjp7ikemnmn54u 79 1 Sosnick Sosnick NNP work_7k7caouvh5efzjp7ikemnmn54u 79 2 et et NNP work_7k7caouvh5efzjp7ikemnmn54u 79 3 al al NNP work_7k7caouvh5efzjp7ikemnmn54u 79 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 80 1 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 80 2 37 37 CD work_7k7caouvh5efzjp7ikemnmn54u 80 3 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 80 4 conclude conclude VBP work_7k7caouvh5efzjp7ikemnmn54u 80 5 that that IN work_7k7caouvh5efzjp7ikemnmn54u 80 6 “ " `` work_7k7caouvh5efzjp7ikemnmn54u 80 7 contrary contrary JJ work_7k7caouvh5efzjp7ikemnmn54u 80 8 to to IN work_7k7caouvh5efzjp7ikemnmn54u 80 9 most most JJS work_7k7caouvh5efzjp7ikemnmn54u 80 10 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 80 11 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 80 12 , , , work_7k7caouvh5efzjp7ikemnmn54u 80 13 wide- wide- RB work_7k7caouvh5efzjp7ikemnmn54u 80 14 spread spread VBN work_7k7caouvh5efzjp7ikemnmn54u 80 15 helix helix NN work_7k7caouvh5efzjp7ikemnmn54u 80 16 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 80 17 not not RB work_7k7caouvh5efzjp7ikemnmn54u 80 18 yet yet RB work_7k7caouvh5efzjp7ikemnmn54u 80 19 formed form VBN work_7k7caouvh5efzjp7ikemnmn54u 80 20 at at IN work_7k7caouvh5efzjp7ikemnmn54u 80 21 the the DT work_7k7caouvh5efzjp7ikemnmn54u 80 22 rate rate NN work_7k7caouvh5efzjp7ikemnmn54u 80 23 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 80 24 limiting limit VBG work_7k7caouvh5efzjp7ikemnmn54u 80 25 step step NN work_7k7caouvh5efzjp7ikemnmn54u 80 26 in in IN work_7k7caouvh5efzjp7ikemnmn54u 80 27 the the DT work_7k7caouvh5efzjp7ikemnmn54u 80 28 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 80 29 pathway pathway NN work_7k7caouvh5efzjp7ikemnmn54u 80 30 . . . work_7k7caouvh5efzjp7ikemnmn54u 80 31 ” " '' work_7k7caouvh5efzjp7ikemnmn54u 80 32 Theoretical theoretical JJ work_7k7caouvh5efzjp7ikemnmn54u 80 33 efforts effort NNS work_7k7caouvh5efzjp7ikemnmn54u 80 34 in in IN work_7k7caouvh5efzjp7ikemnmn54u 80 35 the the DT work_7k7caouvh5efzjp7ikemnmn54u 80 36 framework framework NN work_7k7caouvh5efzjp7ikemnmn54u 80 37 of of IN work_7k7caouvh5efzjp7ikemnmn54u 80 38 simplified simplify VBN work_7k7caouvh5efzjp7ikemnmn54u 80 39 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 80 40 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 80 41 10 10 CD work_7k7caouvh5efzjp7ikemnmn54u 80 42 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 80 43 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 80 44 lead lead VBP work_7k7caouvh5efzjp7ikemnmn54u 80 45 , , , work_7k7caouvh5efzjp7ikemnmn54u 80 46 along along IN work_7k7caouvh5efzjp7ikemnmn54u 80 47 with with IN work_7k7caouvh5efzjp7ikemnmn54u 80 48 experiments experiment NNS work_7k7caouvh5efzjp7ikemnmn54u 80 49 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 80 50 32,38 32,38 CD work_7k7caouvh5efzjp7ikemnmn54u 80 51 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 80 52 , , , work_7k7caouvh5efzjp7ikemnmn54u 80 53 to to IN work_7k7caouvh5efzjp7ikemnmn54u 80 54 the the DT work_7k7caouvh5efzjp7ikemnmn54u 80 55 discovery discovery NN work_7k7caouvh5efzjp7ikemnmn54u 80 56 of of IN work_7k7caouvh5efzjp7ikemnmn54u 80 57 the the DT work_7k7caouvh5efzjp7ikemnmn54u 80 58 nucleation nucleation NN work_7k7caouvh5efzjp7ikemnmn54u 80 59 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 80 60 condensation condensation NN work_7k7caouvh5efzjp7ikemnmn54u 80 61 mechanism mechanism NN work_7k7caouvh5efzjp7ikemnmn54u 80 62 via via IN work_7k7caouvh5efzjp7ikemnmn54u 80 63 formation formation NN work_7k7caouvh5efzjp7ikemnmn54u 80 64 of of IN work_7k7caouvh5efzjp7ikemnmn54u 80 65 a a DT work_7k7caouvh5efzjp7ikemnmn54u 80 66 specific specific JJ work_7k7caouvh5efzjp7ikemnmn54u 80 67 nucleus nucleus NN work_7k7caouvh5efzjp7ikemnmn54u 80 68 in in IN work_7k7caouvh5efzjp7ikemnmn54u 80 69 the the DT work_7k7caouvh5efzjp7ikemnmn54u 80 70 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 80 71 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 80 72 state state NN work_7k7caouvh5efzjp7ikemnmn54u 80 73 . . . work_7k7caouvh5efzjp7ikemnmn54u 81 1 This this DT work_7k7caouvh5efzjp7ikemnmn54u 81 2 mechanism mechanism NN work_7k7caouvh5efzjp7ikemnmn54u 81 3 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 81 4 likely likely JJ work_7k7caouvh5efzjp7ikemnmn54u 81 5 to to TO work_7k7caouvh5efzjp7ikemnmn54u 81 6 capture capture VB work_7k7caouvh5efzjp7ikemnmn54u 81 7 important important JJ work_7k7caouvh5efzjp7ikemnmn54u 81 8 fea- fea- JJ work_7k7caouvh5efzjp7ikemnmn54u 81 9 tures ture NNS work_7k7caouvh5efzjp7ikemnmn54u 81 10 of of IN work_7k7caouvh5efzjp7ikemnmn54u 81 11 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 81 12 kinetics kinetic NNS work_7k7caouvh5efzjp7ikemnmn54u 81 13 of of IN work_7k7caouvh5efzjp7ikemnmn54u 81 14 at at IN work_7k7caouvh5efzjp7ikemnmn54u 81 15 least least JJS work_7k7caouvh5efzjp7ikemnmn54u 81 16 small small JJ work_7k7caouvh5efzjp7ikemnmn54u 81 17 proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 81 18 . . . work_7k7caouvh5efzjp7ikemnmn54u 82 1 Further further RB work_7k7caouvh5efzjp7ikemnmn54u 82 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 82 3 analysis analysis NN work_7k7caouvh5efzjp7ikemnmn54u 82 4 of of IN work_7k7caouvh5efzjp7ikemnmn54u 82 5 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 82 6 model model NN work_7k7caouvh5efzjp7ikemnmn54u 82 7 kinetics kinetic NNS work_7k7caouvh5efzjp7ikemnmn54u 82 8 allowed allow VBD work_7k7caouvh5efzjp7ikemnmn54u 82 9 us -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 82 10 to to TO work_7k7caouvh5efzjp7ikemnmn54u 82 11 develop develop VB work_7k7caouvh5efzjp7ikemnmn54u 82 12 a a DT work_7k7caouvh5efzjp7ikemnmn54u 82 13 successful successful JJ work_7k7caouvh5efzjp7ikemnmn54u 82 14 approach approach NN work_7k7caouvh5efzjp7ikemnmn54u 82 15 to to TO work_7k7caouvh5efzjp7ikemnmn54u 82 16 predict predict VB work_7k7caouvh5efzjp7ikemnmn54u 82 17 the the DT work_7k7caouvh5efzjp7ikemnmn54u 82 18 residues residue NNS work_7k7caouvh5efzjp7ikemnmn54u 82 19 which which WDT work_7k7caouvh5efzjp7ikemnmn54u 82 20 consti- consti- VBZ work_7k7caouvh5efzjp7ikemnmn54u 82 21 tute tute NN work_7k7caouvh5efzjp7ikemnmn54u 82 22 the the DT work_7k7caouvh5efzjp7ikemnmn54u 82 23 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 82 24 nucleus nucleus NN work_7k7caouvh5efzjp7ikemnmn54u 82 25 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 82 26 39 39 CD work_7k7caouvh5efzjp7ikemnmn54u 82 27 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 82 28 , , , work_7k7caouvh5efzjp7ikemnmn54u 82 29 i.e. i.e. FW work_7k7caouvh5efzjp7ikemnmn54u 83 1 making make VBG work_7k7caouvh5efzjp7ikemnmn54u 83 2 even even RB work_7k7caouvh5efzjp7ikemnmn54u 83 3 very very RB work_7k7caouvh5efzjp7ikemnmn54u 83 4 spe- spe- RB work_7k7caouvh5efzjp7ikemnmn54u 83 5 cific cific JJ work_7k7caouvh5efzjp7ikemnmn54u 83 6 predictions prediction NNS work_7k7caouvh5efzjp7ikemnmn54u 83 7 of of IN work_7k7caouvh5efzjp7ikemnmn54u 83 8 the the DT work_7k7caouvh5efzjp7ikemnmn54u 83 9 theory theory NN work_7k7caouvh5efzjp7ikemnmn54u 83 10 testable testable JJ work_7k7caouvh5efzjp7ikemnmn54u 83 11 experimentally experimentally RB work_7k7caouvh5efzjp7ikemnmn54u 83 12 . . . work_7k7caouvh5efzjp7ikemnmn54u 84 1 Finally finally RB work_7k7caouvh5efzjp7ikemnmn54u 84 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 84 3 I -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 84 4 analyze analyze VBP work_7k7caouvh5efzjp7ikemnmn54u 84 5 the the DT work_7k7caouvh5efzjp7ikemnmn54u 84 6 ‘ ' `` work_7k7caouvh5efzjp7ikemnmn54u 84 7 gedanken gedanken JJ work_7k7caouvh5efzjp7ikemnmn54u 84 8 experiment experiment NN work_7k7caouvh5efzjp7ikemnmn54u 84 9 ’ ' '' work_7k7caouvh5efzjp7ikemnmn54u 84 10 interpreted interpret VBN work_7k7caouvh5efzjp7ikemnmn54u 84 11 by by IN work_7k7caouvh5efzjp7ikemnmn54u 84 12 Honig Honig NNP work_7k7caouvh5efzjp7ikemnmn54u 84 13 and and CC work_7k7caouvh5efzjp7ikemnmn54u 84 14 Cohen Cohen NNP work_7k7caouvh5efzjp7ikemnmn54u 84 15 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 84 16 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 84 17 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 84 18 as as IN work_7k7caouvh5efzjp7ikemnmn54u 84 19 a a DT work_7k7caouvh5efzjp7ikemnmn54u 84 20 convincing convincing JJ work_7k7caouvh5efzjp7ikemnmn54u 84 21 proof proof NN work_7k7caouvh5efzjp7ikemnmn54u 84 22 of of IN work_7k7caouvh5efzjp7ikemnmn54u 84 23 the the DT work_7k7caouvh5efzjp7ikemnmn54u 84 24 serious serious JJ work_7k7caouvh5efzjp7ikemnmn54u 84 25 limitations limitation NNS work_7k7caouvh5efzjp7ikemnmn54u 84 26 of of IN work_7k7caouvh5efzjp7ikemnmn54u 84 27 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 84 28 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 84 29 . . . work_7k7caouvh5efzjp7ikemnmn54u 85 1 Honig Honig NNP work_7k7caouvh5efzjp7ikemnmn54u 85 2 and and CC work_7k7caouvh5efzjp7ikemnmn54u 85 3 Cohen Cohen NNP work_7k7caouvh5efzjp7ikemnmn54u 85 4 discuss discuss VBP work_7k7caouvh5efzjp7ikemnmn54u 85 5 experiments experiment NNS work_7k7caouvh5efzjp7ikemnmn54u 85 6 of of IN work_7k7caouvh5efzjp7ikemnmn54u 85 7 Scheraga Scheraga NNP work_7k7caouvh5efzjp7ikemnmn54u 85 8 and and CC work_7k7caouvh5efzjp7ikemnmn54u 85 9 co co NNS work_7k7caouvh5efzjp7ikemnmn54u 85 10 - - NNS work_7k7caouvh5efzjp7ikemnmn54u 85 11 workers worker NNS work_7k7caouvh5efzjp7ikemnmn54u 85 12 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 85 13 40 40 CD work_7k7caouvh5efzjp7ikemnmn54u 85 14 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 85 15 on on IN work_7k7caouvh5efzjp7ikemnmn54u 85 16 conformational conformational JJ work_7k7caouvh5efzjp7ikemnmn54u 85 17 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 85 18 in in IN work_7k7caouvh5efzjp7ikemnmn54u 85 19 polyalanine polyalanine NN work_7k7caouvh5efzjp7ikemnmn54u 85 20 . . . work_7k7caouvh5efzjp7ikemnmn54u 86 1 Alanine Alanine NNP work_7k7caouvh5efzjp7ikemnmn54u 86 2 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 86 3 a a DT work_7k7caouvh5efzjp7ikemnmn54u 86 4 mod- mod- NN work_7k7caouvh5efzjp7ikemnmn54u 86 5 erately erately RB work_7k7caouvh5efzjp7ikemnmn54u 86 6 hydrophobic hydrophobic FW work_7k7caouvh5efzjp7ikemnmn54u 86 7 helix helix NN work_7k7caouvh5efzjp7ikemnmn54u 86 8 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 86 9 stabilizing stabilize VBG work_7k7caouvh5efzjp7ikemnmn54u 86 10 amino amino NN work_7k7caouvh5efzjp7ikemnmn54u 86 11 acid acid NN work_7k7caouvh5efzjp7ikemnmn54u 86 12 . . . work_7k7caouvh5efzjp7ikemnmn54u 87 1 Accord- Accord- NNP work_7k7caouvh5efzjp7ikemnmn54u 87 2 ing ing NNP work_7k7caouvh5efzjp7ikemnmn54u 87 3 to to IN work_7k7caouvh5efzjp7ikemnmn54u 87 4 Honig Honig NNP work_7k7caouvh5efzjp7ikemnmn54u 87 5 and and CC work_7k7caouvh5efzjp7ikemnmn54u 87 6 Cohen Cohen NNP work_7k7caouvh5efzjp7ikemnmn54u 87 7 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 87 8 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 87 9 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 87 10 “ " `` work_7k7caouvh5efzjp7ikemnmn54u 87 11 polyalanine polyalanine NN work_7k7caouvh5efzjp7ikemnmn54u 87 12 , , , work_7k7caouvh5efzjp7ikemnmn54u 87 13 Hn Hn NNP work_7k7caouvh5efzjp7ikemnmn54u 87 14 , , , work_7k7caouvh5efzjp7ikemnmn54u 87 15 forms form VBZ work_7k7caouvh5efzjp7ikemnmn54u 87 16 an an DT work_7k7caouvh5efzjp7ikemnmn54u 87 17 � � NNP work_7k7caouvh5efzjp7ikemnmn54u 87 18 -helix -helix NN work_7k7caouvh5efzjp7ikemnmn54u 87 19 , , , work_7k7caouvh5efzjp7ikemnmn54u 87 20 but but CC work_7k7caouvh5efzjp7ikemnmn54u 87 21 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 87 22 predicted predict VBN work_7k7caouvh5efzjp7ikemnmn54u 87 23 by by IN work_7k7caouvh5efzjp7ikemnmn54u 87 24 sidechain sidechain JJ work_7k7caouvh5efzjp7ikemnmn54u 87 25 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 87 26 only only RB work_7k7caouvh5efzjp7ikemnmn54u 87 27 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 87 28 to to TO work_7k7caouvh5efzjp7ikemnmn54u 87 29 form form VB work_7k7caouvh5efzjp7ikemnmn54u 87 30 an an DT work_7k7caouvh5efzjp7ikemnmn54u 87 31 array array NN work_7k7caouvh5efzjp7ikemnmn54u 87 32 of of IN work_7k7caouvh5efzjp7ikemnmn54u 87 33 compact compact JJ work_7k7caouvh5efzjp7ikemnmn54u 87 34 structures structure NNS work_7k7caouvh5efzjp7ikemnmn54u 87 35 ” " '' work_7k7caouvh5efzjp7ikemnmn54u 87 36 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 87 37 H h NN work_7k7caouvh5efzjp7ikemnmn54u 87 38 stands stand VBZ work_7k7caouvh5efzjp7ikemnmn54u 87 39 for for IN work_7k7caouvh5efzjp7ikemnmn54u 87 40 hydropho- hydropho- NNP work_7k7caouvh5efzjp7ikemnmn54u 87 41 bic bic NNP work_7k7caouvh5efzjp7ikemnmn54u 87 42 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 87 43 . . . work_7k7caouvh5efzjp7ikemnmn54u 88 1 I -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 88 2 was be VBD work_7k7caouvh5efzjp7ikemnmn54u 88 3 quite quite RB work_7k7caouvh5efzjp7ikemnmn54u 88 4 intrigued intrigue VBN work_7k7caouvh5efzjp7ikemnmn54u 88 5 by by IN work_7k7caouvh5efzjp7ikemnmn54u 88 6 this this DT work_7k7caouvh5efzjp7ikemnmn54u 88 7 conclusion conclusion NN work_7k7caouvh5efzjp7ikemnmn54u 88 8 because because IN work_7k7caouvh5efzjp7ikemnmn54u 88 9 it -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 88 10 did do VBD work_7k7caouvh5efzjp7ikemnmn54u 88 11 not not RB work_7k7caouvh5efzjp7ikemnmn54u 88 12 sound sound VB work_7k7caouvh5efzjp7ikemnmn54u 88 13 to to TO work_7k7caouvh5efzjp7ikemnmn54u 88 14 be be VB work_7k7caouvh5efzjp7ikemnmn54u 88 15 consistent consistent JJ work_7k7caouvh5efzjp7ikemnmn54u 88 16 with with IN work_7k7caouvh5efzjp7ikemnmn54u 88 17 statistical statistical JJ work_7k7caouvh5efzjp7ikemnmn54u 88 18 mechanics mechanic NNS work_7k7caouvh5efzjp7ikemnmn54u 88 19 . . . work_7k7caouvh5efzjp7ikemnmn54u 89 1 Indeed indeed RB work_7k7caouvh5efzjp7ikemnmn54u 89 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 89 3 helical helical JJ work_7k7caouvh5efzjp7ikemnmn54u 89 4 conformation conformation NN work_7k7caouvh5efzjp7ikemnmn54u 89 5 in in IN work_7k7caouvh5efzjp7ikemnmn54u 89 6 this this DT work_7k7caouvh5efzjp7ikemnmn54u 89 7 case case NN work_7k7caouvh5efzjp7ikemnmn54u 89 8 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 89 9 unfavorable unfavorable JJ work_7k7caouvh5efzjp7ikemnmn54u 89 10 energetically energetically RB work_7k7caouvh5efzjp7ikemnmn54u 89 11 as as RB work_7k7caouvh5efzjp7ikemnmn54u 89 12 well well RB work_7k7caouvh5efzjp7ikemnmn54u 89 13 as as IN work_7k7caouvh5efzjp7ikemnmn54u 89 14 entropically entropically RB work_7k7caouvh5efzjp7ikemnmn54u 89 15 . . . work_7k7caouvh5efzjp7ikemnmn54u 90 1 Compaction compaction NN work_7k7caouvh5efzjp7ikemnmn54u 90 2 into into IN work_7k7caouvh5efzjp7ikemnmn54u 90 3 glob- glob- JJ work_7k7caouvh5efzjp7ikemnmn54u 90 4 ular ular JJ work_7k7caouvh5efzjp7ikemnmn54u 90 5 state state NN work_7k7caouvh5efzjp7ikemnmn54u 90 6 with with IN work_7k7caouvh5efzjp7ikemnmn54u 90 7 high high JJ work_7k7caouvh5efzjp7ikemnmn54u 90 8 helical helical JJ work_7k7caouvh5efzjp7ikemnmn54u 90 9 content content NN work_7k7caouvh5efzjp7ikemnmn54u 90 10 could could MD work_7k7caouvh5efzjp7ikemnmn54u 90 11 result result VB work_7k7caouvh5efzjp7ikemnmn54u 90 12 in in IN work_7k7caouvh5efzjp7ikemnmn54u 90 13 both both DT work_7k7caouvh5efzjp7ikemnmn54u 90 14 enhanced enhanced JJ work_7k7caouvh5efzjp7ikemnmn54u 90 15 hydrophobic hydrophobic JJ work_7k7caouvh5efzjp7ikemnmn54u 90 16 interactions interaction NNS work_7k7caouvh5efzjp7ikemnmn54u 90 17 and and CC work_7k7caouvh5efzjp7ikemnmn54u 90 18 entropy entropy JJ work_7k7caouvh5efzjp7ikemnmn54u 90 19 increase increase NN work_7k7caouvh5efzjp7ikemnmn54u 90 20 due due IN work_7k7caouvh5efzjp7ikemnmn54u 90 21 to to IN work_7k7caouvh5efzjp7ikemnmn54u 90 22 a a DT work_7k7caouvh5efzjp7ikemnmn54u 90 23 multitude multitude NN work_7k7caouvh5efzjp7ikemnmn54u 90 24 of of IN work_7k7caouvh5efzjp7ikemnmn54u 90 25 available available JJ work_7k7caouvh5efzjp7ikemnmn54u 90 26 compact compact JJ work_7k7caouvh5efzjp7ikemnmn54u 90 27 conformations conformation NNS work_7k7caouvh5efzjp7ikemnmn54u 90 28 . . . work_7k7caouvh5efzjp7ikemnmn54u 91 1 Some some DT work_7k7caouvh5efzjp7ikemnmn54u 91 2 details detail NNS work_7k7caouvh5efzjp7ikemnmn54u 91 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 91 4 the the DT work_7k7caouvh5efzjp7ikemnmn54u 91 5 experiments experiment NNS work_7k7caouvh5efzjp7ikemnmn54u 91 6 of of IN work_7k7caouvh5efzjp7ikemnmn54u 91 7 Scheraga Scheraga NNP work_7k7caouvh5efzjp7ikemnmn54u 91 8 and and CC work_7k7caouvh5efzjp7ikemnmn54u 91 9 co- co- JJ work_7k7caouvh5efzjp7ikemnmn54u 91 10 workers worker NNS work_7k7caouvh5efzjp7ikemnmn54u 91 11 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 91 12 40 40 CD work_7k7caouvh5efzjp7ikemnmn54u 91 13 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 91 14 were be VBD work_7k7caouvh5efzjp7ikemnmn54u 91 15 not not RB work_7k7caouvh5efzjp7ikemnmn54u 91 16 clearly clearly RB work_7k7caouvh5efzjp7ikemnmn54u 91 17 explained explain VBN work_7k7caouvh5efzjp7ikemnmn54u 91 18 by by IN work_7k7caouvh5efzjp7ikemnmn54u 91 19 Honig Honig NNP work_7k7caouvh5efzjp7ikemnmn54u 91 20 and and CC work_7k7caouvh5efzjp7ikemnmn54u 91 21 Cohen Cohen NNP work_7k7caouvh5efzjp7ikemnmn54u 91 22 . . . work_7k7caouvh5efzjp7ikemnmn54u 92 1 Reading read VBG work_7k7caouvh5efzjp7ikemnmn54u 92 2 the the DT work_7k7caouvh5efzjp7ikemnmn54u 92 3 original original JJ work_7k7caouvh5efzjp7ikemnmn54u 92 4 paper paper NN work_7k7caouvh5efzjp7ikemnmn54u 92 5 , , , work_7k7caouvh5efzjp7ikemnmn54u 92 6 I -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 92 7 found find VBD work_7k7caouvh5efzjp7ikemnmn54u 92 8 the the DT work_7k7caouvh5efzjp7ikemnmn54u 92 9 following following NN work_7k7caouvh5efzjp7ikemnmn54u 92 10 . . . work_7k7caouvh5efzjp7ikemnmn54u 93 1 In in IN work_7k7caouvh5efzjp7ikemnmn54u 93 2 order order NN work_7k7caouvh5efzjp7ikemnmn54u 93 3 to to TO work_7k7caouvh5efzjp7ikemnmn54u 93 4 make make VB work_7k7caouvh5efzjp7ikemnmn54u 93 5 their -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 93 6 polymers polymer NNS work_7k7caouvh5efzjp7ikemnmn54u 93 7 soluble soluble JJ work_7k7caouvh5efzjp7ikemnmn54u 93 8 , , , work_7k7caouvh5efzjp7ikemnmn54u 93 9 Scheraga Scheraga NNP work_7k7caouvh5efzjp7ikemnmn54u 93 10 and and CC work_7k7caouvh5efzjp7ikemnmn54u 93 11 co- co- JJ work_7k7caouvh5efzjp7ikemnmn54u 93 12 workers worker NNS work_7k7caouvh5efzjp7ikemnmn54u 93 13 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 93 14 40 40 CD work_7k7caouvh5efzjp7ikemnmn54u 93 15 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 93 16 attached attach VBN work_7k7caouvh5efzjp7ikemnmn54u 93 17 long long RB work_7k7caouvh5efzjp7ikemnmn54u 93 18 charged charge VBN work_7k7caouvh5efzjp7ikemnmn54u 93 19 polylysine polylysine NN work_7k7caouvh5efzjp7ikemnmn54u 93 20 ‘ ' `` work_7k7caouvh5efzjp7ikemnmn54u 93 21 tails tail NNS work_7k7caouvh5efzjp7ikemnmn54u 93 22 ’ ' '' work_7k7caouvh5efzjp7ikemnmn54u 93 23 to to IN work_7k7caouvh5efzjp7ikemnmn54u 93 24 both both DT work_7k7caouvh5efzjp7ikemnmn54u 93 25 ends end NNS work_7k7caouvh5efzjp7ikemnmn54u 93 26 of of IN work_7k7caouvh5efzjp7ikemnmn54u 93 27 the the DT work_7k7caouvh5efzjp7ikemnmn54u 93 28 polyalanine polyalanine NN work_7k7caouvh5efzjp7ikemnmn54u 93 29 . . . work_7k7caouvh5efzjp7ikemnmn54u 94 1 In in IN work_7k7caouvh5efzjp7ikemnmn54u 94 2 salt salt NN work_7k7caouvh5efzjp7ikemnmn54u 94 3 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 94 4 free free JJ work_7k7caouvh5efzjp7ikemnmn54u 94 5 solution solution NN work_7k7caouvh5efzjp7ikemnmn54u 94 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 94 7 where where WRB work_7k7caouvh5efzjp7ikemnmn54u 94 8 Coulomb coulomb NN work_7k7caouvh5efzjp7ikemnmn54u 94 9 repulsion repulsion NN work_7k7caouvh5efzjp7ikemnmn54u 94 10 between between IN work_7k7caouvh5efzjp7ikemnmn54u 94 11 polylysines polylysine NNS work_7k7caouvh5efzjp7ikemnmn54u 94 12 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 94 13 unscreened unscreened JJ work_7k7caouvh5efzjp7ikemnmn54u 94 14 and and CC work_7k7caouvh5efzjp7ikemnmn54u 94 15 overwhelming overwhelming JJ work_7k7caouvh5efzjp7ikemnmn54u 94 16 , , , work_7k7caouvh5efzjp7ikemnmn54u 94 17 the the DT work_7k7caouvh5efzjp7ikemnmn54u 94 18 central central JJ work_7k7caouvh5efzjp7ikemnmn54u 94 19 fragment fragment NN work_7k7caouvh5efzjp7ikemnmn54u 94 20 , , , work_7k7caouvh5efzjp7ikemnmn54u 94 21 polyalanine polyalanine NN work_7k7caouvh5efzjp7ikemnmn54u 94 22 , , , work_7k7caouvh5efzjp7ikemnmn54u 94 23 indeed indeed RB work_7k7caouvh5efzjp7ikemnmn54u 94 24 adopts adopt VBZ work_7k7caouvh5efzjp7ikemnmn54u 94 25 extended extended JJ work_7k7caouvh5efzjp7ikemnmn54u 94 26 helical helical JJ work_7k7caouvh5efzjp7ikemnmn54u 94 27 conformation conformation NN work_7k7caouvh5efzjp7ikemnmn54u 94 28 . . . work_7k7caouvh5efzjp7ikemnmn54u 95 1 When when WRB work_7k7caouvh5efzjp7ikemnmn54u 95 2 salt salt NN work_7k7caouvh5efzjp7ikemnmn54u 95 3 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 95 4 added add VBN work_7k7caouvh5efzjp7ikemnmn54u 95 5 , , , work_7k7caouvh5efzjp7ikemnmn54u 95 6 the the DT work_7k7caouvh5efzjp7ikemnmn54u 95 7 repulsion repulsion NN work_7k7caouvh5efzjp7ikemnmn54u 95 8 between between IN work_7k7caouvh5efzjp7ikemnmn54u 95 9 polylysine polylysine NN work_7k7caouvh5efzjp7ikemnmn54u 95 10 tails tail NNS work_7k7caouvh5efzjp7ikemnmn54u 95 11 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 95 12 screened screen VBN work_7k7caouvh5efzjp7ikemnmn54u 95 13 and and CC work_7k7caouvh5efzjp7ikemnmn54u 95 14 polyalanine polyalanine NN work_7k7caouvh5efzjp7ikemnmn54u 95 15 adopts adopt VBZ work_7k7caouvh5efzjp7ikemnmn54u 95 16 a a DT work_7k7caouvh5efzjp7ikemnmn54u 95 17 compact compact JJ work_7k7caouvh5efzjp7ikemnmn54u 95 18 globular globular JJ work_7k7caouvh5efzjp7ikemnmn54u 95 19 conformation conformation NN work_7k7caouvh5efzjp7ikemnmn54u 95 20 with with IN work_7k7caouvh5efzjp7ikemnmn54u 95 21 high high JJ work_7k7caouvh5efzjp7ikemnmn54u 95 22 helical helical JJ work_7k7caouvh5efzjp7ikemnmn54u 95 23 content content NN work_7k7caouvh5efzjp7ikemnmn54u 95 24 . . . work_7k7caouvh5efzjp7ikemnmn54u 96 1 It -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 96 2 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 96 3 clear clear JJ work_7k7caouvh5efzjp7ikemnmn54u 96 4 that that IN work_7k7caouvh5efzjp7ikemnmn54u 96 5 the the DT work_7k7caouvh5efzjp7ikemnmn54u 96 6 attached attach VBN work_7k7caouvh5efzjp7ikemnmn54u 96 7 polylysine polylysine NN work_7k7caouvh5efzjp7ikemnmn54u 96 8 plays play VBZ work_7k7caouvh5efzjp7ikemnmn54u 96 9 a a DT work_7k7caouvh5efzjp7ikemnmn54u 96 10 crucial crucial JJ work_7k7caouvh5efzjp7ikemnmn54u 96 11 role role NN work_7k7caouvh5efzjp7ikemnmn54u 96 12 in in IN work_7k7caouvh5efzjp7ikemnmn54u 96 13 determining determine VBG work_7k7caouvh5efzjp7ikemnmn54u 96 14 the the DT work_7k7caouvh5efzjp7ikemnmn54u 96 15 confor- confor- NN work_7k7caouvh5efzjp7ikemnmn54u 96 16 mation mation NN work_7k7caouvh5efzjp7ikemnmn54u 96 17 of of IN work_7k7caouvh5efzjp7ikemnmn54u 96 18 the the DT work_7k7caouvh5efzjp7ikemnmn54u 96 19 polyalanine polyalanine JJ work_7k7caouvh5efzjp7ikemnmn54u 96 20 fragment fragment NN work_7k7caouvh5efzjp7ikemnmn54u 96 21 . . . work_7k7caouvh5efzjp7ikemnmn54u 97 1 It -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 97 2 also also RB work_7k7caouvh5efzjp7ikemnmn54u 97 3 explains explain VBZ work_7k7caouvh5efzjp7ikemnmn54u 97 4 why why WRB work_7k7caouvh5efzjp7ikemnmn54u 97 5 longer long JJR work_7k7caouvh5efzjp7ikemnmn54u 97 6 polyalanine polyalanine JJ work_7k7caouvh5efzjp7ikemnmn54u 97 7 helices helix NNS work_7k7caouvh5efzjp7ikemnmn54u 97 8 in in IN work_7k7caouvh5efzjp7ikemnmn54u 97 9 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 97 10 40 40 CD work_7k7caouvh5efzjp7ikemnmn54u 97 11 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 97 12 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 97 13 more more RBR work_7k7caouvh5efzjp7ikemnmn54u 97 14 stable stable JJ work_7k7caouvh5efzjp7ikemnmn54u 97 15 . . . work_7k7caouvh5efzjp7ikemnmn54u 98 1 Short short JJ work_7k7caouvh5efzjp7ikemnmn54u 98 2 polyalanine polyalanine NN work_7k7caouvh5efzjp7ikemnmn54u 98 3 fragments fragment VBZ work_7k7caouvh5efzjp7ikemnmn54u 98 4 force force VBP work_7k7caouvh5efzjp7ikemnmn54u 98 5 polylysine polylysine NN work_7k7caouvh5efzjp7ikemnmn54u 98 6 tails tail NNS work_7k7caouvh5efzjp7ikemnmn54u 98 7 to to TO work_7k7caouvh5efzjp7ikemnmn54u 98 8 come come VB work_7k7caouvh5efzjp7ikemnmn54u 98 9 close close RB work_7k7caouvh5efzjp7ikemnmn54u 98 10 to to IN work_7k7caouvh5efzjp7ikemnmn54u 98 11 each each DT work_7k7caouvh5efzjp7ikemnmn54u 98 12 other other JJ work_7k7caouvh5efzjp7ikemnmn54u 98 13 . . . work_7k7caouvh5efzjp7ikemnmn54u 99 1 Repulsion repulsion NN work_7k7caouvh5efzjp7ikemnmn54u 99 2 between between IN work_7k7caouvh5efzjp7ikemnmn54u 99 3 polylysine polylysine NN work_7k7caouvh5efzjp7ikemnmn54u 99 4 fragments fragment NNS work_7k7caouvh5efzjp7ikemnmn54u 99 5 destroys destroys NNPS work_7k7caouvh5efzjp7ikemnmn54u 99 6 polyalanine polyalanine VBP work_7k7caouvh5efzjp7ikemnmn54u 99 7 helix helix NN work_7k7caouvh5efzjp7ikemnmn54u 99 8 forcing force VBG work_7k7caouvh5efzjp7ikemnmn54u 99 9 the the DT work_7k7caouvh5efzjp7ikemnmn54u 99 10 chain chain NN work_7k7caouvh5efzjp7ikemnmn54u 99 11 into into IN work_7k7caouvh5efzjp7ikemnmn54u 99 12 extremely extremely RB work_7k7caouvh5efzjp7ikemnmn54u 99 13 extended extended JJ work_7k7caouvh5efzjp7ikemnmn54u 99 14 conformation conformation NN work_7k7caouvh5efzjp7ikemnmn54u 99 15 . . . work_7k7caouvh5efzjp7ikemnmn54u 100 1 Longer long JJR work_7k7caouvh5efzjp7ikemnmn54u 100 2 polyalanine polyalanine NN work_7k7caouvh5efzjp7ikemnmn54u 100 3 sequences sequence NNS work_7k7caouvh5efzjp7ikemnmn54u 100 4 experience experience VBP work_7k7caouvh5efzjp7ikemnmn54u 100 5 less less RBR work_7k7caouvh5efzjp7ikemnmn54u 100 6 stretching stretch VBG work_7k7caouvh5efzjp7ikemnmn54u 100 7 force force NN work_7k7caouvh5efzjp7ikemnmn54u 100 8 from from IN work_7k7caouvh5efzjp7ikemnmn54u 100 9 the the DT work_7k7caouvh5efzjp7ikemnmn54u 100 10 polylysine polylysine NN work_7k7caouvh5efzjp7ikemnmn54u 100 11 tails tail NNS work_7k7caouvh5efzjp7ikemnmn54u 100 12 and and CC work_7k7caouvh5efzjp7ikemnmn54u 100 13 , , , work_7k7caouvh5efzjp7ikemnmn54u 100 14 although although IN work_7k7caouvh5efzjp7ikemnmn54u 100 15 they -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 100 16 still still RB work_7k7caouvh5efzjp7ikemnmn54u 100 17 can can MD work_7k7caouvh5efzjp7ikemnmn54u 100 18 not not RB work_7k7caouvh5efzjp7ikemnmn54u 100 19 become become VB work_7k7caouvh5efzjp7ikemnmn54u 100 20 compact compact JJ work_7k7caouvh5efzjp7ikemnmn54u 100 21 in in IN work_7k7caouvh5efzjp7ikemnmn54u 100 22 salt salt NN work_7k7caouvh5efzjp7ikemnmn54u 100 23 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 100 24 free free JJ work_7k7caouvh5efzjp7ikemnmn54u 100 25 solution solution NN work_7k7caouvh5efzjp7ikemnmn54u 100 26 , , , work_7k7caouvh5efzjp7ikemnmn54u 100 27 they -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 100 28 can can MD work_7k7caouvh5efzjp7ikemnmn54u 100 29 become become VB work_7k7caouvh5efzjp7ikemnmn54u 100 30 helical helical JJ work_7k7caouvh5efzjp7ikemnmn54u 100 31 . . . work_7k7caouvh5efzjp7ikemnmn54u 101 1 Most Most JJS work_7k7caouvh5efzjp7ikemnmn54u 101 2 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 101 3 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 101 4 of of IN work_7k7caouvh5efzjp7ikemnmn54u 101 5 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 101 6 do do VBP work_7k7caouvh5efzjp7ikemnmn54u 101 7 not not RB work_7k7caouvh5efzjp7ikemnmn54u 101 8 include include VB work_7k7caouvh5efzjp7ikemnmn54u 101 9 long long JJ work_7k7caouvh5efzjp7ikemnmn54u 101 10 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 101 11 range range NN work_7k7caouvh5efzjp7ikemnmn54u 101 12 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 101 13 in in IN work_7k7caouvh5efzjp7ikemnmn54u 101 14 space space NN work_7k7caouvh5efzjp7ikemnmn54u 101 15 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 101 16 Coulomb Coulomb NNP work_7k7caouvh5efzjp7ikemnmn54u 101 17 forces force NNS work_7k7caouvh5efzjp7ikemnmn54u 101 18 , , , work_7k7caouvh5efzjp7ikemnmn54u 101 19 the the DT work_7k7caouvh5efzjp7ikemnmn54u 101 20 reason reason NN work_7k7caouvh5efzjp7ikemnmn54u 101 21 being be VBG work_7k7caouvh5efzjp7ikemnmn54u 101 22 that that IN work_7k7caouvh5efzjp7ikemnmn54u 101 23 in in IN work_7k7caouvh5efzjp7ikemnmn54u 101 24 most most JJS work_7k7caouvh5efzjp7ikemnmn54u 101 25 cases case NNS work_7k7caouvh5efzjp7ikemnmn54u 101 26 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 101 27 occurs occur VBZ work_7k7caouvh5efzjp7ikemnmn54u 101 28 at at IN work_7k7caouvh5efzjp7ikemnmn54u 101 29 physiological physiological JJ work_7k7caouvh5efzjp7ikemnmn54u 101 30 salt salt NN work_7k7caouvh5efzjp7ikemnmn54u 101 31 concentrations concentration NNS work_7k7caouvh5efzjp7ikemnmn54u 101 32 , , , work_7k7caouvh5efzjp7ikemnmn54u 101 33 at at IN work_7k7caouvh5efzjp7ikemnmn54u 101 34 which which WDT work_7k7caouvh5efzjp7ikemnmn54u 101 35 electrostatic electrostatic JJ work_7k7caouvh5efzjp7ikemnmn54u 101 36 forces force NNS work_7k7caouvh5efzjp7ikemnmn54u 101 37 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 101 38 screened screen VBN work_7k7caouvh5efzjp7ikemnmn54u 101 39 . . . work_7k7caouvh5efzjp7ikemnmn54u 102 1 Long long JJ work_7k7caouvh5efzjp7ikemnmn54u 102 2 helices helix NNS work_7k7caouvh5efzjp7ikemnmn54u 102 3 without without IN work_7k7caouvh5efzjp7ikemnmn54u 102 4 chain chain NN work_7k7caouvh5efzjp7ikemnmn54u 102 5 compaction compaction NN work_7k7caouvh5efzjp7ikemnmn54u 102 6 were be VBD work_7k7caouvh5efzjp7ikemnmn54u 102 7 observed observe VBN work_7k7caouvh5efzjp7ikemnmn54u 102 8 in in IN work_7k7caouvh5efzjp7ikemnmn54u 102 9 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 102 10 40 40 CD work_7k7caouvh5efzjp7ikemnmn54u 102 11 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 102 12 in in IN work_7k7caouvh5efzjp7ikemnmn54u 102 13 salt- salt- NNP work_7k7caouvh5efzjp7ikemnmn54u 102 14 free free JJ work_7k7caouvh5efzjp7ikemnmn54u 102 15 solution solution NN work_7k7caouvh5efzjp7ikemnmn54u 102 16 . . . work_7k7caouvh5efzjp7ikemnmn54u 103 1 A a DT work_7k7caouvh5efzjp7ikemnmn54u 103 2 trivial trivial JJ work_7k7caouvh5efzjp7ikemnmn54u 103 3 modification modification NN work_7k7caouvh5efzjp7ikemnmn54u 103 4 of of IN work_7k7caouvh5efzjp7ikemnmn54u 103 5 a a DT work_7k7caouvh5efzjp7ikemnmn54u 103 6 lattice lattice JJ work_7k7caouvh5efzjp7ikemnmn54u 103 7 model model NN work_7k7caouvh5efzjp7ikemnmn54u 103 8 to to TO work_7k7caouvh5efzjp7ikemnmn54u 103 9 account account VB work_7k7caouvh5efzjp7ikemnmn54u 103 10 for for IN work_7k7caouvh5efzjp7ikemnmn54u 103 11 such such JJ work_7k7caouvh5efzjp7ikemnmn54u 103 12 conditions condition NNS work_7k7caouvh5efzjp7ikemnmn54u 103 13 would would MD work_7k7caouvh5efzjp7ikemnmn54u 103 14 be be VB work_7k7caouvh5efzjp7ikemnmn54u 103 15 to to TO work_7k7caouvh5efzjp7ikemnmn54u 103 16 introduce introduce VB work_7k7caouvh5efzjp7ikemnmn54u 103 17 Coulomb Coulomb NNP work_7k7caouvh5efzjp7ikemnmn54u 103 18 interactions interaction NNS work_7k7caouvh5efzjp7ikemnmn54u 103 19 between between IN work_7k7caouvh5efzjp7ikemnmn54u 103 20 charged charge VBN work_7k7caouvh5efzjp7ikemnmn54u 103 21 monomers monomer NNS work_7k7caouvh5efzjp7ikemnmn54u 103 22 . . . work_7k7caouvh5efzjp7ikemnmn54u 104 1 Then then RB work_7k7caouvh5efzjp7ikemnmn54u 104 2 a a DT work_7k7caouvh5efzjp7ikemnmn54u 104 3 fair fair JJ work_7k7caouvh5efzjp7ikemnmn54u 104 4 comparison comparison NN work_7k7caouvh5efzjp7ikemnmn54u 104 5 with with IN work_7k7caouvh5efzjp7ikemnmn54u 104 6 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 104 7 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 104 8 would would MD work_7k7caouvh5efzjp7ikemnmn54u 104 9 be be VB work_7k7caouvh5efzjp7ikemnmn54u 104 10 to to TO work_7k7caouvh5efzjp7ikemnmn54u 104 11 consider consider VB work_7k7caouvh5efzjp7ikemnmn54u 104 12 a a DT work_7k7caouvh5efzjp7ikemnmn54u 104 13 poly poly JJ work_7k7caouvh5efzjp7ikemnmn54u 104 14 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 104 15 H h NN work_7k7caouvh5efzjp7ikemnmn54u 104 16 sequence sequence NN work_7k7caouvh5efzjp7ikemnmn54u 104 17 with with IN work_7k7caouvh5efzjp7ikemnmn54u 104 18 very very RB work_7k7caouvh5efzjp7ikemnmn54u 104 19 strong strong JJ work_7k7caouvh5efzjp7ikemnmn54u 104 20 unscreened unscreened JJ work_7k7caouvh5efzjp7ikemnmn54u 104 21 Coulomb Coulomb NNP work_7k7caouvh5efzjp7ikemnmn54u 104 22 repulsion repulsion NN work_7k7caouvh5efzjp7ikemnmn54u 104 23 between between IN work_7k7caouvh5efzjp7ikemnmn54u 104 24 the the DT work_7k7caouvh5efzjp7ikemnmn54u 104 25 ends end NNS work_7k7caouvh5efzjp7ikemnmn54u 104 26 . . . work_7k7caouvh5efzjp7ikemnmn54u 105 1 Such such PDT work_7k7caouvh5efzjp7ikemnmn54u 105 2 a a DT work_7k7caouvh5efzjp7ikemnmn54u 105 3 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 105 4 chain chain NN work_7k7caouvh5efzjp7ikemnmn54u 105 5 , , , work_7k7caouvh5efzjp7ikemnmn54u 105 6 under under IN work_7k7caouvh5efzjp7ikemnmn54u 105 7 the the DT work_7k7caouvh5efzjp7ikemnmn54u 105 8 action action NN work_7k7caouvh5efzjp7ikemnmn54u 105 9 of of IN work_7k7caouvh5efzjp7ikemnmn54u 105 10 stretching stretch VBG work_7k7caouvh5efzjp7ikemnmn54u 105 11 force force NN work_7k7caouvh5efzjp7ikemnmn54u 105 12 between between IN work_7k7caouvh5efzjp7ikemnmn54u 105 13 the the DT work_7k7caouvh5efzjp7ikemnmn54u 105 14 ends end NNS work_7k7caouvh5efzjp7ikemnmn54u 105 15 , , , work_7k7caouvh5efzjp7ikemnmn54u 105 16 will will MD work_7k7caouvh5efzjp7ikemnmn54u 105 17 adopt adopt VB work_7k7caouvh5efzjp7ikemnmn54u 105 18 an an DT work_7k7caouvh5efzjp7ikemnmn54u 105 19 extended extended JJ work_7k7caouvh5efzjp7ikemnmn54u 105 20 conformation conformation NN work_7k7caouvh5efzjp7ikemnmn54u 105 21 . . . work_7k7caouvh5efzjp7ikemnmn54u 106 1 Simple simple JJ work_7k7caouvh5efzjp7ikemnmn54u 106 2 addition addition NN work_7k7caouvh5efzjp7ikemnmn54u 106 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 106 4 local local JJ work_7k7caouvh5efzjp7ikemnmn54u 106 5 i i NN work_7k7caouvh5efzjp7ikemnmn54u 106 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 106 7 i+3 i+3 JJR work_7k7caouvh5efzjp7ikemnmn54u 106 8 attraction attraction NN work_7k7caouvh5efzjp7ikemnmn54u 106 9 makes make VBZ work_7k7caouvh5efzjp7ikemnmn54u 106 10 this this DT work_7k7caouvh5efzjp7ikemnmn54u 106 11 extended extend VBN work_7k7caouvh5efzjp7ikemnmn54u 106 12 conformation conformation NN work_7k7caouvh5efzjp7ikemnmn54u 106 13 helical helical JJ work_7k7caouvh5efzjp7ikemnmn54u 106 14 if if IN work_7k7caouvh5efzjp7ikemnmn54u 106 15 the the DT work_7k7caouvh5efzjp7ikemnmn54u 106 16 chain chain NN work_7k7caouvh5efzjp7ikemnmn54u 106 17 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 106 18 long long JJ work_7k7caouvh5efzjp7ikemnmn54u 106 19 enough enough RB work_7k7caouvh5efzjp7ikemnmn54u 106 20 to to TO work_7k7caouvh5efzjp7ikemnmn54u 106 21 keep keep VB work_7k7caouvh5efzjp7ikemnmn54u 106 22 the the DT work_7k7caouvh5efzjp7ikemnmn54u 106 23 ends end NNS work_7k7caouvh5efzjp7ikemnmn54u 106 24 sufficiently sufficiently RB work_7k7caouvh5efzjp7ikemnmn54u 106 25 far far RB work_7k7caouvh5efzjp7ikemnmn54u 106 26 from from IN work_7k7caouvh5efzjp7ikemnmn54u 106 27 each each DT work_7k7caouvh5efzjp7ikemnmn54u 106 28 other other JJ work_7k7caouvh5efzjp7ikemnmn54u 106 29 . . . work_7k7caouvh5efzjp7ikemnmn54u 107 1 This this DT work_7k7caouvh5efzjp7ikemnmn54u 107 2 corresponds correspond VBZ work_7k7caouvh5efzjp7ikemnmn54u 107 3 to to IN work_7k7caouvh5efzjp7ikemnmn54u 107 4 the the DT work_7k7caouvh5efzjp7ikemnmn54u 107 5 salt salt NN work_7k7caouvh5efzjp7ikemnmn54u 107 6 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 107 7 free free JJ work_7k7caouvh5efzjp7ikemnmn54u 107 8 case case NN work_7k7caouvh5efzjp7ikemnmn54u 107 9 of of IN work_7k7caouvh5efzjp7ikemnmn54u 107 10 the the DT work_7k7caouvh5efzjp7ikemnmn54u 107 11 experiment experiment NN work_7k7caouvh5efzjp7ikemnmn54u 107 12 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 107 13 40 40 CD work_7k7caouvh5efzjp7ikemnmn54u 107 14 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 107 15 . . . work_7k7caouvh5efzjp7ikemnmn54u 108 1 When when WRB work_7k7caouvh5efzjp7ikemnmn54u 108 2 the the DT work_7k7caouvh5efzjp7ikemnmn54u 108 3 repulsion repulsion NN work_7k7caouvh5efzjp7ikemnmn54u 108 4 between between IN work_7k7caouvh5efzjp7ikemnmn54u 108 5 chain chain NN work_7k7caouvh5efzjp7ikemnmn54u 108 6 ends end VBZ work_7k7caouvh5efzjp7ikemnmn54u 108 7 diminishes diminishe NNS work_7k7caouvh5efzjp7ikemnmn54u 108 8 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 108 9 upon upon IN work_7k7caouvh5efzjp7ikemnmn54u 108 10 addition addition NN work_7k7caouvh5efzjp7ikemnmn54u 108 11 of of IN work_7k7caouvh5efzjp7ikemnmn54u 108 12 salt salt NN work_7k7caouvh5efzjp7ikemnmn54u 108 13 in in IN work_7k7caouvh5efzjp7ikemnmn54u 108 14 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 108 15 40 40 CD work_7k7caouvh5efzjp7ikemnmn54u 108 16 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 108 17 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 108 18 , , , work_7k7caouvh5efzjp7ikemnmn54u 108 19 hydrophobic hydrophobic NN work_7k7caouvh5efzjp7ikemnmn54u 108 20 attraction attraction NN work_7k7caouvh5efzjp7ikemnmn54u 108 21 takes take VBZ work_7k7caouvh5efzjp7ikemnmn54u 108 22 over over RP work_7k7caouvh5efzjp7ikemnmn54u 108 23 and and CC work_7k7caouvh5efzjp7ikemnmn54u 108 24 the the DT work_7k7caouvh5efzjp7ikemnmn54u 108 25 chain chain NN work_7k7caouvh5efzjp7ikemnmn54u 108 26 becomes become VBZ work_7k7caouvh5efzjp7ikemnmn54u 108 27 compact compact JJ work_7k7caouvh5efzjp7ikemnmn54u 108 28 in in IN work_7k7caouvh5efzjp7ikemnmn54u 108 29 the the DT work_7k7caouvh5efzjp7ikemnmn54u 108 30 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 108 31 model model NN work_7k7caouvh5efzjp7ikemnmn54u 108 32 , , , work_7k7caouvh5efzjp7ikemnmn54u 108 33 in in IN work_7k7caouvh5efzjp7ikemnmn54u 108 34 agreement agreement NN work_7k7caouvh5efzjp7ikemnmn54u 108 35 with with IN work_7k7caouvh5efzjp7ikemnmn54u 108 36 basic basic JJ work_7k7caouvh5efzjp7ikemnmn54u 108 37 statistical statistical JJ work_7k7caouvh5efzjp7ikemnmn54u 108 38 mechanics mechanic NNS work_7k7caouvh5efzjp7ikemnmn54u 108 39 and and CC work_7k7caouvh5efzjp7ikemnmn54u 108 40 the the DT work_7k7caouvh5efzjp7ikemnmn54u 108 41 experiment experiment NN work_7k7caouvh5efzjp7ikemnmn54u 108 42 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 108 43 40 40 CD work_7k7caouvh5efzjp7ikemnmn54u 108 44 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 108 45 . . . work_7k7caouvh5efzjp7ikemnmn54u 109 1 Moreover moreover RB work_7k7caouvh5efzjp7ikemnmn54u 109 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 109 3 when when WRB work_7k7caouvh5efzjp7ikemnmn54u 109 4 local local JJ work_7k7caouvh5efzjp7ikemnmn54u 109 5 i i PRP work_7k7caouvh5efzjp7ikemnmn54u 109 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 109 7 i+3 i+3 `` work_7k7caouvh5efzjp7ikemnmn54u 109 8 attrac- attrac- NNP work_7k7caouvh5efzjp7ikemnmn54u 109 9 tion tion NN work_7k7caouvh5efzjp7ikemnmn54u 109 10 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 109 11 modeling model VBG work_7k7caouvh5efzjp7ikemnmn54u 109 12 hydrogen hydrogen NN work_7k7caouvh5efzjp7ikemnmn54u 109 13 bond bond NNP work_7k7caouvh5efzjp7ikemnmn54u 109 14 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 109 15 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 109 16 added add VBN work_7k7caouvh5efzjp7ikemnmn54u 109 17 along along IN work_7k7caouvh5efzjp7ikemnmn54u 109 18 with with IN work_7k7caouvh5efzjp7ikemnmn54u 109 19 hydrophobic hydrophobic JJ work_7k7caouvh5efzjp7ikemnmn54u 109 20 attraction attraction NN work_7k7caouvh5efzjp7ikemnmn54u 109 21 in in IN work_7k7caouvh5efzjp7ikemnmn54u 109 22 the the DT work_7k7caouvh5efzjp7ikemnmn54u 109 23 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 109 24 model model NN work_7k7caouvh5efzjp7ikemnmn54u 109 25 , , , work_7k7caouvh5efzjp7ikemnmn54u 109 26 the the DT work_7k7caouvh5efzjp7ikemnmn54u 109 27 resulting result VBG work_7k7caouvh5efzjp7ikemnmn54u 109 28 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 109 29 conformations conformation NNS work_7k7caouvh5efzjp7ikemnmn54u 109 30 were be VBD work_7k7caouvh5efzjp7ikemnmn54u 109 31 shown show VBN work_7k7caouvh5efzjp7ikemnmn54u 109 32 to to TO work_7k7caouvh5efzjp7ikemnmn54u 109 33 be be VB work_7k7caouvh5efzjp7ikemnmn54u 109 34 compact compact JJ work_7k7caouvh5efzjp7ikemnmn54u 109 35 and and CC work_7k7caouvh5efzjp7ikemnmn54u 109 36 helical helical JJ work_7k7caouvh5efzjp7ikemnmn54u 109 37 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 109 38 see see VB work_7k7caouvh5efzjp7ikemnmn54u 109 39 Fig Fig NNP work_7k7caouvh5efzjp7ikemnmn54u 109 40 . . . work_7k7caouvh5efzjp7ikemnmn54u 110 1 2a 2a CD work_7k7caouvh5efzjp7ikemnmn54u 110 2 in in IN work_7k7caouvh5efzjp7ikemnmn54u 110 3 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 110 4 10 10 CD work_7k7caouvh5efzjp7ikemnmn54u 110 5 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 110 6 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 110 7 , , , work_7k7caouvh5efzjp7ikemnmn54u 110 8 exactly exactly RB work_7k7caouvh5efzjp7ikemnmn54u 110 9 like like IN work_7k7caouvh5efzjp7ikemnmn54u 110 10 the the DT work_7k7caouvh5efzjp7ikemnmn54u 110 11 ones one NNS work_7k7caouvh5efzjp7ikemnmn54u 110 12 in in IN work_7k7caouvh5efzjp7ikemnmn54u 110 13 the the DT work_7k7caouvh5efzjp7ikemnmn54u 110 14 high high JJ work_7k7caouvh5efzjp7ikemnmn54u 110 15 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 110 16 salt salt NN work_7k7caouvh5efzjp7ikemnmn54u 110 17 case case NN work_7k7caouvh5efzjp7ikemnmn54u 110 18 in in IN work_7k7caouvh5efzjp7ikemnmn54u 110 19 the the DT work_7k7caouvh5efzjp7ikemnmn54u 110 20 experiment experiment NN work_7k7caouvh5efzjp7ikemnmn54u 110 21 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 110 22 40 40 CD work_7k7caouvh5efzjp7ikemnmn54u 110 23 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 110 24 . . . work_7k7caouvh5efzjp7ikemnmn54u 111 1 Summarizing summarize VBG work_7k7caouvh5efzjp7ikemnmn54u 111 2 the the DT work_7k7caouvh5efzjp7ikemnmn54u 111 3 dis- dis- JJ work_7k7caouvh5efzjp7ikemnmn54u 111 4 cussion cussion NN work_7k7caouvh5efzjp7ikemnmn54u 111 5 of of IN work_7k7caouvh5efzjp7ikemnmn54u 111 6 the the DT work_7k7caouvh5efzjp7ikemnmn54u 111 7 ‘ ' `` work_7k7caouvh5efzjp7ikemnmn54u 111 8 gedanken gedanken JJ work_7k7caouvh5efzjp7ikemnmn54u 111 9 experiment experiment NN work_7k7caouvh5efzjp7ikemnmn54u 111 10 ’ ' '' work_7k7caouvh5efzjp7ikemnmn54u 111 11 , , , work_7k7caouvh5efzjp7ikemnmn54u 111 12 I -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 111 13 note note VBP work_7k7caouvh5efzjp7ikemnmn54u 111 14 that that IN work_7k7caouvh5efzjp7ikemnmn54u 111 15 , , , work_7k7caouvh5efzjp7ikemnmn54u 111 16 opposite opposite RB work_7k7caouvh5efzjp7ikemnmn54u 111 17 to to IN work_7k7caouvh5efzjp7ikemnmn54u 111 18 the the DT work_7k7caouvh5efzjp7ikemnmn54u 111 19 claim claim NN work_7k7caouvh5efzjp7ikemnmn54u 111 20 of of IN work_7k7caouvh5efzjp7ikemnmn54u 111 21 Honig Honig NNP work_7k7caouvh5efzjp7ikemnmn54u 111 22 and and CC work_7k7caouvh5efzjp7ikemnmn54u 111 23 Cohen Cohen NNP work_7k7caouvh5efzjp7ikemnmn54u 111 24 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 111 25 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 111 26 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 111 27 , , , work_7k7caouvh5efzjp7ikemnmn54u 111 28 the the DT work_7k7caouvh5efzjp7ikemnmn54u 111 29 results result NNS work_7k7caouvh5efzjp7ikemnmn54u 111 30 of of IN work_7k7caouvh5efzjp7ikemnmn54u 111 31 this this DT work_7k7caouvh5efzjp7ikemnmn54u 111 32 elegant elegant JJ work_7k7caouvh5efzjp7ikemnmn54u 111 33 study study NN work_7k7caouvh5efzjp7ikemnmn54u 111 34 of of IN work_7k7caouvh5efzjp7ikemnmn54u 111 35 Scheraga Scheraga NNP work_7k7caouvh5efzjp7ikemnmn54u 111 36 and and CC work_7k7caouvh5efzjp7ikemnmn54u 111 37 co co NNS work_7k7caouvh5efzjp7ikemnmn54u 111 38 - - NNS work_7k7caouvh5efzjp7ikemnmn54u 111 39 workers worker NNS work_7k7caouvh5efzjp7ikemnmn54u 111 40 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 111 41 40 40 CD work_7k7caouvh5efzjp7ikemnmn54u 111 42 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 111 43 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 111 44 consis- consis- VBN work_7k7caouvh5efzjp7ikemnmn54u 111 45 tent tent NN work_7k7caouvh5efzjp7ikemnmn54u 111 46 with with IN work_7k7caouvh5efzjp7ikemnmn54u 111 47 statistical statistical JJ work_7k7caouvh5efzjp7ikemnmn54u 111 48 mechanics mechanic NNS work_7k7caouvh5efzjp7ikemnmn54u 111 49 and and CC work_7k7caouvh5efzjp7ikemnmn54u 111 50 can can MD work_7k7caouvh5efzjp7ikemnmn54u 111 51 be be VB work_7k7caouvh5efzjp7ikemnmn54u 111 52 rationalized rationalize VBN work_7k7caouvh5efzjp7ikemnmn54u 111 53 within within IN work_7k7caouvh5efzjp7ikemnmn54u 111 54 simple simple JJ work_7k7caouvh5efzjp7ikemnmn54u 111 55 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 111 56 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 111 57 . . . work_7k7caouvh5efzjp7ikemnmn54u 112 1 In in IN work_7k7caouvh5efzjp7ikemnmn54u 112 2 fact fact NN work_7k7caouvh5efzjp7ikemnmn54u 112 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 112 4 a a DT work_7k7caouvh5efzjp7ikemnmn54u 112 5 statistical statistical JJ work_7k7caouvh5efzjp7ikemnmn54u 112 6 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 112 7 mechani- mechani- NN work_7k7caouvh5efzjp7ikemnmn54u 112 8 cal cal NN work_7k7caouvh5efzjp7ikemnmn54u 112 9 rationale rationale NN work_7k7caouvh5efzjp7ikemnmn54u 112 10 for for IN work_7k7caouvh5efzjp7ikemnmn54u 112 11 the the DT work_7k7caouvh5efzjp7ikemnmn54u 112 12 observed observed JJ work_7k7caouvh5efzjp7ikemnmn54u 112 13 effects effect NNS work_7k7caouvh5efzjp7ikemnmn54u 112 14 was be VBD work_7k7caouvh5efzjp7ikemnmn54u 112 15 given give VBN work_7k7caouvh5efzjp7ikemnmn54u 112 16 already already RB work_7k7caouvh5efzjp7ikemnmn54u 112 17 in in IN work_7k7caouvh5efzjp7ikemnmn54u 112 18 the the DT work_7k7caouvh5efzjp7ikemnmn54u 112 19 original original JJ work_7k7caouvh5efzjp7ikemnmn54u 112 20 paper paper NN work_7k7caouvh5efzjp7ikemnmn54u 112 21 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 112 22 40 40 CD work_7k7caouvh5efzjp7ikemnmn54u 112 23 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 112 24 . . . work_7k7caouvh5efzjp7ikemnmn54u 113 1 It -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 113 2 will will MD work_7k7caouvh5efzjp7ikemnmn54u 113 3 be be VB work_7k7caouvh5efzjp7ikemnmn54u 113 4 a a DT work_7k7caouvh5efzjp7ikemnmn54u 113 5 matter matter NN work_7k7caouvh5efzjp7ikemnmn54u 113 6 of of IN work_7k7caouvh5efzjp7ikemnmn54u 113 7 interest interest NN work_7k7caouvh5efzjp7ikemnmn54u 113 8 in in IN work_7k7caouvh5efzjp7ikemnmn54u 113 9 future future JJ work_7k7caouvh5efzjp7ikemnmn54u 113 10 study study NN work_7k7caouvh5efzjp7ikemnmn54u 113 11 to to IN work_7k7caouvh5efzjp7ikemnmn54u 113 12 model model VB work_7k7caouvh5efzjp7ikemnmn54u 113 13 block block NN work_7k7caouvh5efzjp7ikemnmn54u 113 14 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 113 15 copolymer copolymer NN work_7k7caouvh5efzjp7ikemnmn54u 113 16 polypeptides polypeptide NNS work_7k7caouvh5efzjp7ikemnmn54u 113 17 like like IN work_7k7caouvh5efzjp7ikemnmn54u 113 18 the the DT work_7k7caouvh5efzjp7ikemnmn54u 113 19 ones one NNS work_7k7caouvh5efzjp7ikemnmn54u 113 20 studied study VBN work_7k7caouvh5efzjp7ikemnmn54u 113 21 by by IN work_7k7caouvh5efzjp7ikemnmn54u 113 22 Scheraga Scheraga NNP work_7k7caouvh5efzjp7ikemnmn54u 113 23 and and CC work_7k7caouvh5efzjp7ikemnmn54u 113 24 co co NNS work_7k7caouvh5efzjp7ikemnmn54u 113 25 - - NNS work_7k7caouvh5efzjp7ikemnmn54u 113 26 workers worker NNS work_7k7caouvh5efzjp7ikemnmn54u 113 27 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 113 28 40 40 CD work_7k7caouvh5efzjp7ikemnmn54u 113 29 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 113 30 . . . work_7k7caouvh5efzjp7ikemnmn54u 114 1 Lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 114 2 and and CC work_7k7caouvh5efzjp7ikemnmn54u 114 3 other other JJ work_7k7caouvh5efzjp7ikemnmn54u 114 4 simplified simplify VBN work_7k7caouvh5efzjp7ikemnmn54u 114 5 analytical analytical JJ work_7k7caouvh5efzjp7ikemnmn54u 114 6 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 114 7 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 114 8 the the DT work_7k7caouvh5efzjp7ikemnmn54u 114 9 sta- sta- JJ work_7k7caouvh5efzjp7ikemnmn54u 114 10 tistical tistical JJ work_7k7caouvh5efzjp7ikemnmn54u 114 11 mechanician mechanician NN work_7k7caouvh5efzjp7ikemnmn54u 114 12 ’s ’s POS work_7k7caouvh5efzjp7ikemnmn54u 114 13 contributions contribution NNS work_7k7caouvh5efzjp7ikemnmn54u 114 14 to to IN work_7k7caouvh5efzjp7ikemnmn54u 114 15 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 114 16 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 114 17 . . . work_7k7caouvh5efzjp7ikemnmn54u 115 1 It -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 115 2 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 115 3 part part NN work_7k7caouvh5efzjp7ikemnmn54u 115 4 of of IN work_7k7caouvh5efzjp7ikemnmn54u 115 5 the the DT work_7k7caouvh5efzjp7ikemnmn54u 115 6 culture culture NN work_7k7caouvh5efzjp7ikemnmn54u 115 7 in in IN work_7k7caouvh5efzjp7ikemnmn54u 115 8 this this DT work_7k7caouvh5efzjp7ikemnmn54u 115 9 field field NN work_7k7caouvh5efzjp7ikemnmn54u 115 10 to to TO work_7k7caouvh5efzjp7ikemnmn54u 115 11 appreciate appreciate VB work_7k7caouvh5efzjp7ikemnmn54u 115 12 that that IN work_7k7caouvh5efzjp7ikemnmn54u 115 13 simpli- simpli- NN work_7k7caouvh5efzjp7ikemnmn54u 115 14 fied fie VBN work_7k7caouvh5efzjp7ikemnmn54u 115 15 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 115 16 provide provide VBP work_7k7caouvh5efzjp7ikemnmn54u 115 17 coarse coarse RB work_7k7caouvh5efzjp7ikemnmn54u 115 18 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 115 19 grained grain VBN work_7k7caouvh5efzjp7ikemnmn54u 115 20 descriptions description NNS work_7k7caouvh5efzjp7ikemnmn54u 115 21 and and CC work_7k7caouvh5efzjp7ikemnmn54u 115 22 as as RB work_7k7caouvh5efzjp7ikemnmn54u 115 23 such such JJ work_7k7caouvh5efzjp7ikemnmn54u 115 24 they -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 115 25 may may MD work_7k7caouvh5efzjp7ikemnmn54u 115 26 be be VB work_7k7caouvh5efzjp7ikemnmn54u 115 27 adequate adequate JJ work_7k7caouvh5efzjp7ikemnmn54u 115 28 to to TO work_7k7caouvh5efzjp7ikemnmn54u 115 29 describe describe VB work_7k7caouvh5efzjp7ikemnmn54u 115 30 the the DT work_7k7caouvh5efzjp7ikemnmn54u 115 31 effects effect NNS work_7k7caouvh5efzjp7ikemnmn54u 115 32 taking take VBG work_7k7caouvh5efzjp7ikemnmn54u 115 33 place place NN work_7k7caouvh5efzjp7ikemnmn54u 115 34 on on IN work_7k7caouvh5efzjp7ikemnmn54u 115 35 longer long JJR work_7k7caouvh5efzjp7ikemnmn54u 115 36 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 115 37 than than IN work_7k7caouvh5efzjp7ikemnmn54u 115 38 microscopic microscopic JJ work_7k7caouvh5efzjp7ikemnmn54u 115 39 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 115 40 time time NN work_7k7caouvh5efzjp7ikemnmn54u 115 41 and and CC work_7k7caouvh5efzjp7ikemnmn54u 115 42 length length NN work_7k7caouvh5efzjp7ikemnmn54u 115 43 scales scale NNS work_7k7caouvh5efzjp7ikemnmn54u 115 44 . . . work_7k7caouvh5efzjp7ikemnmn54u 116 1 The the DT work_7k7caouvh5efzjp7ikemnmn54u 116 2 most most RBS work_7k7caouvh5efzjp7ikemnmn54u 116 3 important important JJ work_7k7caouvh5efzjp7ikemnmn54u 116 4 example example NN work_7k7caouvh5efzjp7ikemnmn54u 116 5 of of IN work_7k7caouvh5efzjp7ikemnmn54u 116 6 this this DT work_7k7caouvh5efzjp7ikemnmn54u 116 7 kind kind NN work_7k7caouvh5efzjp7ikemnmn54u 116 8 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 116 9 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 116 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 116 11 and and CC work_7k7caouvh5efzjp7ikemnmn54u 116 12 I -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 116 13 have have VBP work_7k7caouvh5efzjp7ikemnmn54u 116 14 presented present VBN work_7k7caouvh5efzjp7ikemnmn54u 116 15 evidence evidence NN work_7k7caouvh5efzjp7ikemnmn54u 116 16 here here RB work_7k7caouvh5efzjp7ikemnmn54u 116 17 that that IN work_7k7caouvh5efzjp7ikemnmn54u 116 18 statistical statistical JJ work_7k7caouvh5efzjp7ikemnmn54u 116 19 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 116 20 mechanical mechanical JJ work_7k7caouvh5efzjp7ikemnmn54u 116 21 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 116 22 do do VBP work_7k7caouvh5efzjp7ikemnmn54u 116 23 capture capture VB work_7k7caouvh5efzjp7ikemnmn54u 116 24 many many JJ work_7k7caouvh5efzjp7ikemnmn54u 116 25 essential essential JJ work_7k7caouvh5efzjp7ikemnmn54u 116 26 features feature NNS work_7k7caouvh5efzjp7ikemnmn54u 116 27 of of IN work_7k7caouvh5efzjp7ikemnmn54u 116 28 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 116 29 . . . work_7k7caouvh5efzjp7ikemnmn54u 117 1 Certainly certainly RB work_7k7caouvh5efzjp7ikemnmn54u 117 2 such such JJ work_7k7caouvh5efzjp7ikemnmn54u 117 3 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 117 4 have have VBP work_7k7caouvh5efzjp7ikemnmn54u 117 5 their -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 117 6 limitations limitation NNS work_7k7caouvh5efzjp7ikemnmn54u 117 7 . . . work_7k7caouvh5efzjp7ikemnmn54u 118 1 Many many JJ work_7k7caouvh5efzjp7ikemnmn54u 118 2 impor- impor- JJ work_7k7caouvh5efzjp7ikemnmn54u 118 3 tant tant JJ work_7k7caouvh5efzjp7ikemnmn54u 118 4 effects effect NNS work_7k7caouvh5efzjp7ikemnmn54u 118 5 , , , work_7k7caouvh5efzjp7ikemnmn54u 118 6 such such JJ work_7k7caouvh5efzjp7ikemnmn54u 118 7 as as IN work_7k7caouvh5efzjp7ikemnmn54u 118 8 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 118 9 function function NN work_7k7caouvh5efzjp7ikemnmn54u 118 10 or or CC work_7k7caouvh5efzjp7ikemnmn54u 118 11 ligand ligand NN work_7k7caouvh5efzjp7ikemnmn54u 118 12 binding bind VBG work_7k7caouvh5efzjp7ikemnmn54u 118 13 specificity specificity NN work_7k7caouvh5efzjp7ikemnmn54u 118 14 , , , work_7k7caouvh5efzjp7ikemnmn54u 118 15 occur occur VB work_7k7caouvh5efzjp7ikemnmn54u 118 16 on on IN work_7k7caouvh5efzjp7ikemnmn54u 118 17 microscopic microscopic JJ work_7k7caouvh5efzjp7ikemnmn54u 118 18 length length NN work_7k7caouvh5efzjp7ikemnmn54u 118 19 and and CC work_7k7caouvh5efzjp7ikemnmn54u 118 20 time time NN work_7k7caouvh5efzjp7ikemnmn54u 118 21 scales scale NNS work_7k7caouvh5efzjp7ikemnmn54u 118 22 . . . work_7k7caouvh5efzjp7ikemnmn54u 119 1 Lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 119 2 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 119 3 do do VBP work_7k7caouvh5efzjp7ikemnmn54u 119 4 not not RB work_7k7caouvh5efzjp7ikemnmn54u 119 5 provide provide VB work_7k7caouvh5efzjp7ikemnmn54u 119 6 a a DT work_7k7caouvh5efzjp7ikemnmn54u 119 7 sufficient sufficient JJ work_7k7caouvh5efzjp7ikemnmn54u 119 8 degree degree NN work_7k7caouvh5efzjp7ikemnmn54u 119 9 of of IN work_7k7caouvh5efzjp7ikemnmn54u 119 10 detail detail NN work_7k7caouvh5efzjp7ikemnmn54u 119 11 to to TO work_7k7caouvh5efzjp7ikemnmn54u 119 12 study study VB work_7k7caouvh5efzjp7ikemnmn54u 119 13 these these DT work_7k7caouvh5efzjp7ikemnmn54u 119 14 phenomena phenomenon NNS work_7k7caouvh5efzjp7ikemnmn54u 119 15 . . . work_7k7caouvh5efzjp7ikemnmn54u 120 1 Their -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 120 2 analysis analysis NN work_7k7caouvh5efzjp7ikemnmn54u 120 3 requires require VBZ work_7k7caouvh5efzjp7ikemnmn54u 120 4 all- all- RB work_7k7caouvh5efzjp7ikemnmn54u 120 5 atom atom NN work_7k7caouvh5efzjp7ikemnmn54u 120 6 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 120 7 and and CC work_7k7caouvh5efzjp7ikemnmn54u 120 8 molecular molecular JJ work_7k7caouvh5efzjp7ikemnmn54u 120 9 dynamics dynamic NNS work_7k7caouvh5efzjp7ikemnmn54u 120 10 simulations simulation NNS work_7k7caouvh5efzjp7ikemnmn54u 120 11 [ [ -LRB- work_7k7caouvh5efzjp7ikemnmn54u 120 12 41 41 CD work_7k7caouvh5efzjp7ikemnmn54u 120 13 ] ] -RRB- work_7k7caouvh5efzjp7ikemnmn54u 120 14 . . . work_7k7caouvh5efzjp7ikemnmn54u 121 1 Besides besides IN work_7k7caouvh5efzjp7ikemnmn54u 121 2 that that DT work_7k7caouvh5efzjp7ikemnmn54u 121 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 121 4 there there EX work_7k7caouvh5efzjp7ikemnmn54u 121 5 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 121 6 a a DT work_7k7caouvh5efzjp7ikemnmn54u 121 7 number number NN work_7k7caouvh5efzjp7ikemnmn54u 121 8 of of IN work_7k7caouvh5efzjp7ikemnmn54u 121 9 aspects aspect NNS work_7k7caouvh5efzjp7ikemnmn54u 121 10 of of IN work_7k7caouvh5efzjp7ikemnmn54u 121 11 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 121 12 that that WDT work_7k7caouvh5efzjp7ikemnmn54u 121 13 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 121 14 more more RBR work_7k7caouvh5efzjp7ikemnmn54u 121 15 microscopic microscopic JJ work_7k7caouvh5efzjp7ikemnmn54u 121 16 in in IN work_7k7caouvh5efzjp7ikemnmn54u 121 17 nature nature NN work_7k7caouvh5efzjp7ikemnmn54u 121 18 for for IN work_7k7caouvh5efzjp7ikemnmn54u 121 19 which which WDT work_7k7caouvh5efzjp7ikemnmn54u 121 20 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 121 21 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 121 22 , , , work_7k7caouvh5efzjp7ikemnmn54u 121 23 in in IN work_7k7caouvh5efzjp7ikemnmn54u 121 24 their -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 121 25 present present JJ work_7k7caouvh5efzjp7ikemnmn54u 121 26 form form NN work_7k7caouvh5efzjp7ikemnmn54u 121 27 , , , work_7k7caouvh5efzjp7ikemnmn54u 121 28 can can MD work_7k7caouvh5efzjp7ikemnmn54u 121 29 have have VB work_7k7caouvh5efzjp7ikemnmn54u 121 30 problems problem NNS work_7k7caouvh5efzjp7ikemnmn54u 121 31 . . . work_7k7caouvh5efzjp7ikemnmn54u 122 1 One one CD work_7k7caouvh5efzjp7ikemnmn54u 122 2 example example NN work_7k7caouvh5efzjp7ikemnmn54u 122 3 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 122 4 proline proline JJ work_7k7caouvh5efzjp7ikemnmn54u 122 5 isomerization isomerization NN work_7k7caouvh5efzjp7ikemnmn54u 122 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 122 7 which which WDT work_7k7caouvh5efzjp7ikemnmn54u 122 8 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 122 9 known know VBN work_7k7caouvh5efzjp7ikemnmn54u 122 10 to to TO work_7k7caouvh5efzjp7ikemnmn54u 122 11 prevent prevent VB work_7k7caouvh5efzjp7ikemnmn54u 122 12 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 122 13 if if IN work_7k7caouvh5efzjp7ikemnmn54u 122 14 proline proline JJ work_7k7caouvh5efzjp7ikemnmn54u 122 15 isomers isomer NNS work_7k7caouvh5efzjp7ikemnmn54u 122 16 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 122 17 incorrect incorrect JJ work_7k7caouvh5efzjp7ikemnmn54u 122 18 . . . work_7k7caouvh5efzjp7ikemnmn54u 123 1 Other other JJ work_7k7caouvh5efzjp7ikemnmn54u 123 2 issues issue NNS work_7k7caouvh5efzjp7ikemnmn54u 123 3 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 123 4 chirality chirality NN work_7k7caouvh5efzjp7ikemnmn54u 123 5 of of IN work_7k7caouvh5efzjp7ikemnmn54u 123 6 amino amino JJ work_7k7caouvh5efzjp7ikemnmn54u 123 7 acids acid NNS work_7k7caouvh5efzjp7ikemnmn54u 123 8 and and CC work_7k7caouvh5efzjp7ikemnmn54u 123 9 tight tight JJ work_7k7caouvh5efzjp7ikemnmn54u 123 10 packing packing NN work_7k7caouvh5efzjp7ikemnmn54u 123 11 of of IN work_7k7caouvh5efzjp7ikemnmn54u 123 12 sidechains sidechain NNS work_7k7caouvh5efzjp7ikemnmn54u 123 13 . . . work_7k7caouvh5efzjp7ikemnmn54u 124 1 These these DT work_7k7caouvh5efzjp7ikemnmn54u 124 2 aspects aspect NNS work_7k7caouvh5efzjp7ikemnmn54u 124 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 124 4 the the DT work_7k7caouvh5efzjp7ikemnmn54u 124 5 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 124 6 problem problem NN work_7k7caouvh5efzjp7ikemnmn54u 124 7 can can MD work_7k7caouvh5efzjp7ikemnmn54u 124 8 be be VB work_7k7caouvh5efzjp7ikemnmn54u 124 9 addressed address VBN work_7k7caouvh5efzjp7ikemnmn54u 124 10 in in IN work_7k7caouvh5efzjp7ikemnmn54u 124 11 the the DT work_7k7caouvh5efzjp7ikemnmn54u 124 12 framework framework NN work_7k7caouvh5efzjp7ikemnmn54u 124 13 of of IN work_7k7caouvh5efzjp7ikemnmn54u 124 14 more more RBR work_7k7caouvh5efzjp7ikemnmn54u 124 15 atomistic atomistic JJ work_7k7caouvh5efzjp7ikemnmn54u 124 16 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 124 17 , , , work_7k7caouvh5efzjp7ikemnmn54u 124 18 which which WDT work_7k7caouvh5efzjp7ikemnmn54u 124 19 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 124 20 currently currently RB work_7k7caouvh5efzjp7ikemnmn54u 124 21 not not RB work_7k7caouvh5efzjp7ikemnmn54u 124 22 feasible feasible JJ work_7k7caouvh5efzjp7ikemnmn54u 124 23 for for IN work_7k7caouvh5efzjp7ikemnmn54u 124 24 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 124 25 simulations simulation NNS work_7k7caouvh5efzjp7ikemnmn54u 124 26 . . . work_7k7caouvh5efzjp7ikemnmn54u 125 1 It -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 125 2 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 125 3 also also RB work_7k7caouvh5efzjp7ikemnmn54u 125 4 possible possible JJ work_7k7caouvh5efzjp7ikemnmn54u 125 5 that that IN work_7k7caouvh5efzjp7ikemnmn54u 125 6 more more RBR work_7k7caouvh5efzjp7ikemnmn54u 125 7 detailed detailed JJ work_7k7caouvh5efzjp7ikemnmn54u 125 8 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 125 9 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 125 10 needed need VBN work_7k7caouvh5efzjp7ikemnmn54u 125 11 to to TO work_7k7caouvh5efzjp7ikemnmn54u 125 12 address address VB work_7k7caouvh5efzjp7ikemnmn54u 125 13 the the DT work_7k7caouvh5efzjp7ikemnmn54u 125 14 second second JJ work_7k7caouvh5efzjp7ikemnmn54u 125 15 , , , work_7k7caouvh5efzjp7ikemnmn54u 125 16 more more RBR work_7k7caouvh5efzjp7ikemnmn54u 125 17 visible visible JJ work_7k7caouvh5efzjp7ikemnmn54u 125 18 to to IN work_7k7caouvh5efzjp7ikemnmn54u 125 19 the the DT work_7k7caouvh5efzjp7ikemnmn54u 125 20 public public NN work_7k7caouvh5efzjp7ikemnmn54u 125 21 , , , work_7k7caouvh5efzjp7ikemnmn54u 125 22 side side NN work_7k7caouvh5efzjp7ikemnmn54u 125 23 of of IN work_7k7caouvh5efzjp7ikemnmn54u 125 24 the the DT work_7k7caouvh5efzjp7ikemnmn54u 125 25 ‘ ' `` work_7k7caouvh5efzjp7ikemnmn54u 125 26 holy holy NNP work_7k7caouvh5efzjp7ikemnmn54u 125 27 grail grail NNP work_7k7caouvh5efzjp7ikemnmn54u 125 28 ’ ' '' work_7k7caouvh5efzjp7ikemnmn54u 125 29 of of IN work_7k7caouvh5efzjp7ikemnmn54u 125 30 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 125 31 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 125 32 — — : work_7k7caouvh5efzjp7ikemnmn54u 125 33 prediction prediction NN work_7k7caouvh5efzjp7ikemnmn54u 125 34 of of IN work_7k7caouvh5efzjp7ikemnmn54u 125 35 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 125 36 con- con- NN work_7k7caouvh5efzjp7ikemnmn54u 125 37 formation formation NN work_7k7caouvh5efzjp7ikemnmn54u 125 38 . . . work_7k7caouvh5efzjp7ikemnmn54u 126 1 Conclusive conclusive JJ work_7k7caouvh5efzjp7ikemnmn54u 126 2 successes success NNS work_7k7caouvh5efzjp7ikemnmn54u 126 3 in in IN work_7k7caouvh5efzjp7ikemnmn54u 126 4 that that DT work_7k7caouvh5efzjp7ikemnmn54u 126 5 direction direction NN work_7k7caouvh5efzjp7ikemnmn54u 126 6 may may MD work_7k7caouvh5efzjp7ikemnmn54u 126 7 be be VB work_7k7caouvh5efzjp7ikemnmn54u 126 8 for for IN work_7k7caouvh5efzjp7ikemnmn54u 126 9 the the DT work_7k7caouvh5efzjp7ikemnmn54u 126 10 distant distant JJ work_7k7caouvh5efzjp7ikemnmn54u 126 11 future future NN work_7k7caouvh5efzjp7ikemnmn54u 126 12 , , , work_7k7caouvh5efzjp7ikemnmn54u 126 13 despite despite IN work_7k7caouvh5efzjp7ikemnmn54u 126 14 considerable considerable JJ work_7k7caouvh5efzjp7ikemnmn54u 126 15 progress progress NN work_7k7caouvh5efzjp7ikemnmn54u 126 16 achieved achieve VBN work_7k7caouvh5efzjp7ikemnmn54u 126 17 in in IN work_7k7caouvh5efzjp7ikemnmn54u 126 18 the the DT work_7k7caouvh5efzjp7ikemnmn54u 126 19 elucidation elucidation NN work_7k7caouvh5efzjp7ikemnmn54u 126 20 of of IN work_7k7caouvh5efzjp7ikemnmn54u 126 21 the the DT work_7k7caouvh5efzjp7ikemnmn54u 126 22 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 126 23 mechanism mechanism NN work_7k7caouvh5efzjp7ikemnmn54u 126 24 . . . work_7k7caouvh5efzjp7ikemnmn54u 127 1 This this DT work_7k7caouvh5efzjp7ikemnmn54u 127 2 situation situation NN work_7k7caouvh5efzjp7ikemnmn54u 127 3 has have VBZ work_7k7caouvh5efzjp7ikemnmn54u 127 4 many many JJ work_7k7caouvh5efzjp7ikemnmn54u 127 5 analogies analogy NNS work_7k7caouvh5efzjp7ikemnmn54u 127 6 with with IN work_7k7caouvh5efzjp7ikemnmn54u 127 7 other other JJ work_7k7caouvh5efzjp7ikemnmn54u 127 8 fields field NNS work_7k7caouvh5efzjp7ikemnmn54u 127 9 of of IN work_7k7caouvh5efzjp7ikemnmn54u 127 10 physics physics NN work_7k7caouvh5efzjp7ikemnmn54u 127 11 or or CC work_7k7caouvh5efzjp7ikemnmn54u 127 12 chemistry chemistry NN work_7k7caouvh5efzjp7ikemnmn54u 127 13 where where WRB work_7k7caouvh5efzjp7ikemnmn54u 127 14 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 127 15 often often RB work_7k7caouvh5efzjp7ikemnmn54u 127 16 adequately adequately RB work_7k7caouvh5efzjp7ikemnmn54u 127 17 tackle tackle VBP work_7k7caouvh5efzjp7ikemnmn54u 127 18 fundamental fundamental JJ work_7k7caouvh5efzjp7ikemnmn54u 127 19 large large JJ work_7k7caouvh5efzjp7ikemnmn54u 127 20 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 127 21 scale scale NN work_7k7caouvh5efzjp7ikemnmn54u 127 22 behavior behavior NN work_7k7caouvh5efzjp7ikemnmn54u 127 23 but but CC work_7k7caouvh5efzjp7ikemnmn54u 127 24 do do VBP work_7k7caouvh5efzjp7ikemnmn54u 127 25 not not RB work_7k7caouvh5efzjp7ikemnmn54u 127 26 capture capture VB work_7k7caouvh5efzjp7ikemnmn54u 127 27 all all DT work_7k7caouvh5efzjp7ikemnmn54u 127 28 microscopic microscopic JJ work_7k7caouvh5efzjp7ikemnmn54u 127 29 properties property NNS work_7k7caouvh5efzjp7ikemnmn54u 127 30 . . . work_7k7caouvh5efzjp7ikemnmn54u 128 1 One one CD work_7k7caouvh5efzjp7ikemnmn54u 128 2 example example NN work_7k7caouvh5efzjp7ikemnmn54u 128 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 128 4 this this DT work_7k7caouvh5efzjp7ikemnmn54u 128 5 kind kind NN work_7k7caouvh5efzjp7ikemnmn54u 128 6 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 128 7 that that IN work_7k7caouvh5efzjp7ikemnmn54u 128 8 although although IN work_7k7caouvh5efzjp7ikemnmn54u 128 9 crystallization crystallization NN work_7k7caouvh5efzjp7ikemnmn54u 128 10 as as IN work_7k7caouvh5efzjp7ikemnmn54u 128 11 a a DT work_7k7caouvh5efzjp7ikemnmn54u 128 12 physical physical JJ work_7k7caouvh5efzjp7ikemnmn54u 128 13 phenom- phenom- NN work_7k7caouvh5efzjp7ikemnmn54u 128 14 enon enon NNP work_7k7caouvh5efzjp7ikemnmn54u 128 15 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 128 16 understood understand VBN work_7k7caouvh5efzjp7ikemnmn54u 128 17 , , , work_7k7caouvh5efzjp7ikemnmn54u 128 18 we -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 128 19 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 128 20 still still RB work_7k7caouvh5efzjp7ikemnmn54u 128 21 unable unable JJ work_7k7caouvh5efzjp7ikemnmn54u 128 22 to to TO work_7k7caouvh5efzjp7ikemnmn54u 128 23 predict predict VB work_7k7caouvh5efzjp7ikemnmn54u 128 24 crystal crystal NN work_7k7caouvh5efzjp7ikemnmn54u 128 25 symmetry symmetry NN work_7k7caouvh5efzjp7ikemnmn54u 128 26 from from IN work_7k7caouvh5efzjp7ikemnmn54u 128 27 the the DT work_7k7caouvh5efzjp7ikemnmn54u 128 28 chemical chemical NN work_7k7caouvh5efzjp7ikemnmn54u 128 29 structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 128 30 of of IN work_7k7caouvh5efzjp7ikemnmn54u 128 31 the the DT work_7k7caouvh5efzjp7ikemnmn54u 128 32 constituting constitute VBG work_7k7caouvh5efzjp7ikemnmn54u 128 33 molecules molecule NNS work_7k7caouvh5efzjp7ikemnmn54u 128 34 . . . work_7k7caouvh5efzjp7ikemnmn54u 129 1 I -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 129 2 believe believe VBP work_7k7caouvh5efzjp7ikemnmn54u 129 3 that that IN work_7k7caouvh5efzjp7ikemnmn54u 129 4 it -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 129 5 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 129 6 indeed indeed RB work_7k7caouvh5efzjp7ikemnmn54u 129 7 important important JJ work_7k7caouvh5efzjp7ikemnmn54u 129 8 to to TO work_7k7caouvh5efzjp7ikemnmn54u 129 9 appreciate appreciate VB work_7k7caouvh5efzjp7ikemnmn54u 129 10 the the DT work_7k7caouvh5efzjp7ikemnmn54u 129 11 real real JJ work_7k7caouvh5efzjp7ikemnmn54u 129 12 limitations limitation NNS work_7k7caouvh5efzjp7ikemnmn54u 129 13 of of IN work_7k7caouvh5efzjp7ikemnmn54u 129 14 popular popular JJ work_7k7caouvh5efzjp7ikemnmn54u 129 15 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 129 16 . . . work_7k7caouvh5efzjp7ikemnmn54u 130 1 Detailed detailed JJ work_7k7caouvh5efzjp7ikemnmn54u 130 2 objective objective JJ work_7k7caouvh5efzjp7ikemnmn54u 130 3 analysis analysis NN work_7k7caouvh5efzjp7ikemnmn54u 130 4 of of IN work_7k7caouvh5efzjp7ikemnmn54u 130 5 experiments experiment NNS work_7k7caouvh5efzjp7ikemnmn54u 130 6 which which WDT work_7k7caouvh5efzjp7ikemnmn54u 130 7 can can MD work_7k7caouvh5efzjp7ikemnmn54u 130 8 not not RB work_7k7caouvh5efzjp7ikemnmn54u 130 9 be be VB work_7k7caouvh5efzjp7ikemnmn54u 130 10 explained explain VBN work_7k7caouvh5efzjp7ikemnmn54u 130 11 by by IN work_7k7caouvh5efzjp7ikemnmn54u 130 12 existing exist VBG work_7k7caouvh5efzjp7ikemnmn54u 130 13 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 130 14 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 130 15 a a DT work_7k7caouvh5efzjp7ikemnmn54u 130 16 means means NN work_7k7caouvh5efzjp7ikemnmn54u 130 17 to to TO work_7k7caouvh5efzjp7ikemnmn54u 130 18 elucidate elucidate VB work_7k7caouvh5efzjp7ikemnmn54u 130 19 such such JJ work_7k7caouvh5efzjp7ikemnmn54u 130 20 limitations limitation NNS work_7k7caouvh5efzjp7ikemnmn54u 130 21 . . . work_7k7caouvh5efzjp7ikemnmn54u 131 1 This this DT work_7k7caouvh5efzjp7ikemnmn54u 131 2 can can MD work_7k7caouvh5efzjp7ikemnmn54u 131 3 be be VB work_7k7caouvh5efzjp7ikemnmn54u 131 4 a a DT work_7k7caouvh5efzjp7ikemnmn54u 131 5 powerful powerful JJ work_7k7caouvh5efzjp7ikemnmn54u 131 6 stimulus stimulus NN work_7k7caouvh5efzjp7ikemnmn54u 131 7 for for IN work_7k7caouvh5efzjp7ikemnmn54u 131 8 further further JJ work_7k7caouvh5efzjp7ikemnmn54u 131 9 development development NN work_7k7caouvh5efzjp7ikemnmn54u 131 10 of of IN work_7k7caouvh5efzjp7ikemnmn54u 131 11 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 131 12 and and CC work_7k7caouvh5efzjp7ikemnmn54u 131 13 theory theory NN work_7k7caouvh5efzjp7ikemnmn54u 131 14 . . . work_7k7caouvh5efzjp7ikemnmn54u 132 1 It -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 132 2 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 132 3 an an DT work_7k7caouvh5efzjp7ikemnmn54u 132 4 exciting exciting JJ work_7k7caouvh5efzjp7ikemnmn54u 132 5 time time NN work_7k7caouvh5efzjp7ikemnmn54u 132 6 in in IN work_7k7caouvh5efzjp7ikemnmn54u 132 7 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 132 8 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 132 9 because because IN work_7k7caouvh5efzjp7ikemnmn54u 132 10 theory theory NN work_7k7caouvh5efzjp7ikemnmn54u 132 11 and and CC work_7k7caouvh5efzjp7ikemnmn54u 132 12 experiment experiment NN work_7k7caouvh5efzjp7ikemnmn54u 132 13 have have VBP work_7k7caouvh5efzjp7ikemnmn54u 132 14 started start VBN work_7k7caouvh5efzjp7ikemnmn54u 132 15 to to TO work_7k7caouvh5efzjp7ikemnmn54u 132 16 talk talk VB work_7k7caouvh5efzjp7ikemnmn54u 132 17 to to IN work_7k7caouvh5efzjp7ikemnmn54u 132 18 each each DT work_7k7caouvh5efzjp7ikemnmn54u 132 19 other other JJ work_7k7caouvh5efzjp7ikemnmn54u 132 20 and and CC work_7k7caouvh5efzjp7ikemnmn54u 132 21 agree- agree- NNP work_7k7caouvh5efzjp7ikemnmn54u 132 22 ment ment NNP work_7k7caouvh5efzjp7ikemnmn54u 132 23 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 132 24 encouraging encouraging JJ work_7k7caouvh5efzjp7ikemnmn54u 132 25 . . . work_7k7caouvh5efzjp7ikemnmn54u 133 1 Though though IN work_7k7caouvh5efzjp7ikemnmn54u 133 2 the the DT work_7k7caouvh5efzjp7ikemnmn54u 133 3 scope scope NN work_7k7caouvh5efzjp7ikemnmn54u 133 4 of of IN work_7k7caouvh5efzjp7ikemnmn54u 133 5 simplified simplify VBN work_7k7caouvh5efzjp7ikemnmn54u 133 6 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 133 7 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 133 8 models model NNS work_7k7caouvh5efzjp7ikemnmn54u 133 9 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 133 10 limited limited JJ work_7k7caouvh5efzjp7ikemnmn54u 133 11 , , , work_7k7caouvh5efzjp7ikemnmn54u 133 12 they -PRON- PRP work_7k7caouvh5efzjp7ikemnmn54u 133 13 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 133 14 proving prove VBG work_7k7caouvh5efzjp7ikemnmn54u 133 15 to to TO work_7k7caouvh5efzjp7ikemnmn54u 133 16 be be VB work_7k7caouvh5efzjp7ikemnmn54u 133 17 a a DT work_7k7caouvh5efzjp7ikemnmn54u 133 18 very very RB work_7k7caouvh5efzjp7ikemnmn54u 133 19 useful useful JJ work_7k7caouvh5efzjp7ikemnmn54u 133 20 tool tool NN work_7k7caouvh5efzjp7ikemnmn54u 133 21 to to TO work_7k7caouvh5efzjp7ikemnmn54u 133 22 study study VB work_7k7caouvh5efzjp7ikemnmn54u 133 23 fundamental fundamental JJ work_7k7caouvh5efzjp7ikemnmn54u 133 24 principles principle NNS work_7k7caouvh5efzjp7ikemnmn54u 133 25 of of IN work_7k7caouvh5efzjp7ikemnmn54u 133 26 this this DT work_7k7caouvh5efzjp7ikemnmn54u 133 27 fascinating fascinating JJ work_7k7caouvh5efzjp7ikemnmn54u 133 28 phenomenon phenomenon NN work_7k7caouvh5efzjp7ikemnmn54u 133 29 . . . work_7k7caouvh5efzjp7ikemnmn54u 134 1 References reference NNS work_7k7caouvh5efzjp7ikemnmn54u 134 2 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 134 3 . . . work_7k7caouvh5efzjp7ikemnmn54u 135 1 Honig Honig NNP work_7k7caouvh5efzjp7ikemnmn54u 135 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 135 3 B. B. NNP work_7k7caouvh5efzjp7ikemnmn54u 136 1 & & CC work_7k7caouvh5efzjp7ikemnmn54u 136 2 Cohen Cohen NNP work_7k7caouvh5efzjp7ikemnmn54u 136 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 136 4 F. F. NNP work_7k7caouvh5efzjp7ikemnmn54u 136 5 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 136 6 1996 1996 CD work_7k7caouvh5efzjp7ikemnmn54u 136 7 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 136 8 . . . work_7k7caouvh5efzjp7ikemnmn54u 137 1 Adding add VBG work_7k7caouvh5efzjp7ikemnmn54u 137 2 backbone backbone NN work_7k7caouvh5efzjp7ikemnmn54u 137 3 to to IN work_7k7caouvh5efzjp7ikemnmn54u 137 4 protein protein VB work_7k7caouvh5efzjp7ikemnmn54u 137 5 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 137 6 : : : work_7k7caouvh5efzjp7ikemnmn54u 137 7 why why WRB work_7k7caouvh5efzjp7ikemnmn54u 137 8 proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 137 9 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 137 10 polypeptides polypeptide NNS work_7k7caouvh5efzjp7ikemnmn54u 137 11 . . . work_7k7caouvh5efzjp7ikemnmn54u 138 1 Folding Folding NNP work_7k7caouvh5efzjp7ikemnmn54u 138 2 & & CC work_7k7caouvh5efzjp7ikemnmn54u 138 3 Design Design NNP work_7k7caouvh5efzjp7ikemnmn54u 138 4 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 138 5 , , , work_7k7caouvh5efzjp7ikemnmn54u 138 6 R17–R20 r17–r20 XX work_7k7caouvh5efzjp7ikemnmn54u 138 7 ; ; : work_7k7caouvh5efzjp7ikemnmn54u 138 8 1359- 1359- CD work_7k7caouvh5efzjp7ikemnmn54u 138 9 0278 0278 CD work_7k7caouvh5efzjp7ikemnmn54u 138 10 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 138 11 001-R0017 001-r0017 CD work_7k7caouvh5efzjp7ikemnmn54u 138 12 . . . work_7k7caouvh5efzjp7ikemnmn54u 139 1 2 2 LS work_7k7caouvh5efzjp7ikemnmn54u 139 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 140 1 Skolnick Skolnick NNP work_7k7caouvh5efzjp7ikemnmn54u 140 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 140 3 J. J. NNP work_7k7caouvh5efzjp7ikemnmn54u 141 1 & & CC work_7k7caouvh5efzjp7ikemnmn54u 141 2 Kolinski Kolinski NNP work_7k7caouvh5efzjp7ikemnmn54u 141 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 141 4 A. a. NN work_7k7caouvh5efzjp7ikemnmn54u 142 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 142 2 1991 1991 CD work_7k7caouvh5efzjp7ikemnmn54u 142 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 142 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 143 1 Dynamic dynamic JJ work_7k7caouvh5efzjp7ikemnmn54u 143 2 monte monte JJ work_7k7caouvh5efzjp7ikemnmn54u 143 3 carlo carlo JJ work_7k7caouvh5efzjp7ikemnmn54u 143 4 simulations simulation NNS work_7k7caouvh5efzjp7ikemnmn54u 143 5 of of IN work_7k7caouvh5efzjp7ikemnmn54u 143 6 a a DT work_7k7caouvh5efzjp7ikemnmn54u 143 7 new new JJ work_7k7caouvh5efzjp7ikemnmn54u 143 8 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 143 9 model model NN work_7k7caouvh5efzjp7ikemnmn54u 143 10 of of IN work_7k7caouvh5efzjp7ikemnmn54u 143 11 globular globular JJ work_7k7caouvh5efzjp7ikemnmn54u 143 12 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 143 13 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 143 14 , , , work_7k7caouvh5efzjp7ikemnmn54u 143 15 structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 143 16 and and CC work_7k7caouvh5efzjp7ikemnmn54u 143 17 dynamics dynamic NNS work_7k7caouvh5efzjp7ikemnmn54u 143 18 J. J. NNP work_7k7caouvh5efzjp7ikemnmn54u 143 19 Mol Mol NNP work_7k7caouvh5efzjp7ikemnmn54u 143 20 . . . work_7k7caouvh5efzjp7ikemnmn54u 144 1 Biol Biol NNP work_7k7caouvh5efzjp7ikemnmn54u 144 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 145 1 221 221 CD work_7k7caouvh5efzjp7ikemnmn54u 145 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 145 3 499–531 499–531 CD work_7k7caouvh5efzjp7ikemnmn54u 145 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 146 1 3 3 LS work_7k7caouvh5efzjp7ikemnmn54u 146 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 147 1 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 147 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 147 3 E. E. NNP work_7k7caouvh5efzjp7ikemnmn54u 147 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 147 5 Farztdinov Farztdinov NNP work_7k7caouvh5efzjp7ikemnmn54u 147 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 147 7 G.M. G.M. NNP work_7k7caouvh5efzjp7ikemnmn54u 147 8 , , , work_7k7caouvh5efzjp7ikemnmn54u 147 9 Gutin Gutin NNP work_7k7caouvh5efzjp7ikemnmn54u 147 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 147 11 A.M. A.M. NNP work_7k7caouvh5efzjp7ikemnmn54u 147 12 & & CC work_7k7caouvh5efzjp7ikemnmn54u 147 13 Karplus Karplus NNP work_7k7caouvh5efzjp7ikemnmn54u 147 14 , , , work_7k7caouvh5efzjp7ikemnmn54u 147 15 M. M. NNP work_7k7caouvh5efzjp7ikemnmn54u 147 16 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 147 17 1991 1991 CD work_7k7caouvh5efzjp7ikemnmn54u 147 18 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 147 19 . . . work_7k7caouvh5efzjp7ikemnmn54u 148 1 Protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 148 2 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 148 3 bottlenecks bottleneck NNS work_7k7caouvh5efzjp7ikemnmn54u 148 4 : : : work_7k7caouvh5efzjp7ikemnmn54u 148 5 a a DT work_7k7caouvh5efzjp7ikemnmn54u 148 6 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 148 7 monte monte JJ work_7k7caouvh5efzjp7ikemnmn54u 148 8 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 148 9 carlo carlo JJ work_7k7caouvh5efzjp7ikemnmn54u 148 10 simulation simulation NN work_7k7caouvh5efzjp7ikemnmn54u 148 11 . . . work_7k7caouvh5efzjp7ikemnmn54u 149 1 Phys phys NN work_7k7caouvh5efzjp7ikemnmn54u 149 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 150 1 Rev. Rev. NNP work_7k7caouvh5efzjp7ikemnmn54u 151 1 Lett Lett NNP work_7k7caouvh5efzjp7ikemnmn54u 151 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 152 1 67 67 CD work_7k7caouvh5efzjp7ikemnmn54u 152 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 152 3 1665–1667 1665–1667 CD work_7k7caouvh5efzjp7ikemnmn54u 152 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 153 1 4 4 LS work_7k7caouvh5efzjp7ikemnmn54u 153 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 154 1 Sali Sali NNP work_7k7caouvh5efzjp7ikemnmn54u 154 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 154 3 A. A. NNP work_7k7caouvh5efzjp7ikemnmn54u 154 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 154 5 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 154 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 154 7 E. E. NNP work_7k7caouvh5efzjp7ikemnmn54u 154 8 & & CC work_7k7caouvh5efzjp7ikemnmn54u 154 9 Karplus Karplus NNP work_7k7caouvh5efzjp7ikemnmn54u 154 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 154 11 M. M. NNP work_7k7caouvh5efzjp7ikemnmn54u 154 12 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 154 13 1994 1994 CD work_7k7caouvh5efzjp7ikemnmn54u 154 14 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 154 15 . . . work_7k7caouvh5efzjp7ikemnmn54u 155 1 How how WRB work_7k7caouvh5efzjp7ikemnmn54u 155 2 does do VBZ work_7k7caouvh5efzjp7ikemnmn54u 155 3 a a DT work_7k7caouvh5efzjp7ikemnmn54u 155 4 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 155 5 fold fold VB work_7k7caouvh5efzjp7ikemnmn54u 155 6 ? ? . work_7k7caouvh5efzjp7ikemnmn54u 156 1 Nature nature NN work_7k7caouvh5efzjp7ikemnmn54u 156 2 369 369 CD work_7k7caouvh5efzjp7ikemnmn54u 156 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 156 4 248–251 248–251 CD work_7k7caouvh5efzjp7ikemnmn54u 156 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 157 1 5 5 CD work_7k7caouvh5efzjp7ikemnmn54u 157 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 158 1 Miller Miller NNP work_7k7caouvh5efzjp7ikemnmn54u 158 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 158 3 R. R. NNP work_7k7caouvh5efzjp7ikemnmn54u 158 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 158 5 Danko Danko NNP work_7k7caouvh5efzjp7ikemnmn54u 158 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 158 7 C. C. NNP work_7k7caouvh5efzjp7ikemnmn54u 158 8 , , , work_7k7caouvh5efzjp7ikemnmn54u 158 9 Fasolka Fasolka NNP work_7k7caouvh5efzjp7ikemnmn54u 158 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 158 11 M.J. M.J. NNP work_7k7caouvh5efzjp7ikemnmn54u 158 12 , , , work_7k7caouvh5efzjp7ikemnmn54u 158 13 Balazs Balazs NNP work_7k7caouvh5efzjp7ikemnmn54u 158 14 , , , work_7k7caouvh5efzjp7ikemnmn54u 158 15 A.C. A.C. NNP work_7k7caouvh5efzjp7ikemnmn54u 158 16 , , , work_7k7caouvh5efzjp7ikemnmn54u 158 17 Chan Chan NNP work_7k7caouvh5efzjp7ikemnmn54u 158 18 , , , work_7k7caouvh5efzjp7ikemnmn54u 158 19 H.S. H.S. NNP work_7k7caouvh5efzjp7ikemnmn54u 159 1 & & CC work_7k7caouvh5efzjp7ikemnmn54u 159 2 Dill Dill NNP work_7k7caouvh5efzjp7ikemnmn54u 159 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 159 4 K.A. K.A. NNP work_7k7caouvh5efzjp7ikemnmn54u 160 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 160 2 1992 1992 CD work_7k7caouvh5efzjp7ikemnmn54u 160 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 160 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 161 1 Folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 161 2 kinetics kinetic NNS work_7k7caouvh5efzjp7ikemnmn54u 161 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 161 4 proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 161 5 and and CC work_7k7caouvh5efzjp7ikemnmn54u 161 6 copolymers copolymer NNS work_7k7caouvh5efzjp7ikemnmn54u 161 7 . . . work_7k7caouvh5efzjp7ikemnmn54u 162 1 J. J. NNP work_7k7caouvh5efzjp7ikemnmn54u 162 2 Chem Chem NNP work_7k7caouvh5efzjp7ikemnmn54u 162 3 . . . work_7k7caouvh5efzjp7ikemnmn54u 163 1 Phys phys NN work_7k7caouvh5efzjp7ikemnmn54u 163 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 164 1 96 96 CD work_7k7caouvh5efzjp7ikemnmn54u 164 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 164 3 768–780 768–780 CD work_7k7caouvh5efzjp7ikemnmn54u 164 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 165 1 6 6 CD work_7k7caouvh5efzjp7ikemnmn54u 165 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 166 1 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 166 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 166 3 E. E. NNP work_7k7caouvh5efzjp7ikemnmn54u 166 4 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 166 5 1994 1994 CD work_7k7caouvh5efzjp7ikemnmn54u 166 6 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 166 7 . . . work_7k7caouvh5efzjp7ikemnmn54u 167 1 Proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 167 2 with with IN work_7k7caouvh5efzjp7ikemnmn54u 167 3 selected select VBN work_7k7caouvh5efzjp7ikemnmn54u 167 4 sequences sequence NNS work_7k7caouvh5efzjp7ikemnmn54u 167 5 fold fold VBP work_7k7caouvh5efzjp7ikemnmn54u 167 6 to to IN work_7k7caouvh5efzjp7ikemnmn54u 167 7 their -PRON- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 167 8 unique unique JJ work_7k7caouvh5efzjp7ikemnmn54u 167 9 native native JJ work_7k7caouvh5efzjp7ikemnmn54u 167 10 conformation conformation NN work_7k7caouvh5efzjp7ikemnmn54u 167 11 . . . work_7k7caouvh5efzjp7ikemnmn54u 168 1 Phys phys NN work_7k7caouvh5efzjp7ikemnmn54u 168 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 169 1 Rev. Rev. NNP work_7k7caouvh5efzjp7ikemnmn54u 170 1 Lett Lett NNP work_7k7caouvh5efzjp7ikemnmn54u 170 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 171 1 72 72 CD work_7k7caouvh5efzjp7ikemnmn54u 171 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 171 3 3907–3910 3907–3910 CD work_7k7caouvh5efzjp7ikemnmn54u 171 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 172 1 7 7 LS work_7k7caouvh5efzjp7ikemnmn54u 172 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 173 1 Hao Hao NNP work_7k7caouvh5efzjp7ikemnmn54u 173 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 173 3 M.-H. M.-H. NNP work_7k7caouvh5efzjp7ikemnmn54u 173 4 & & CC work_7k7caouvh5efzjp7ikemnmn54u 173 5 Scheraga Scheraga NNP work_7k7caouvh5efzjp7ikemnmn54u 173 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 173 7 H. H. NNP work_7k7caouvh5efzjp7ikemnmn54u 173 8 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 173 9 1994 1994 CD work_7k7caouvh5efzjp7ikemnmn54u 173 10 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 173 11 . . . work_7k7caouvh5efzjp7ikemnmn54u 174 1 Monte Monte NNP work_7k7caouvh5efzjp7ikemnmn54u 174 2 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 174 3 carlo carlo JJ work_7k7caouvh5efzjp7ikemnmn54u 174 4 simulation simulation NN work_7k7caouvh5efzjp7ikemnmn54u 174 5 of of IN work_7k7caouvh5efzjp7ikemnmn54u 174 6 a a DT work_7k7caouvh5efzjp7ikemnmn54u 174 7 first first JJ work_7k7caouvh5efzjp7ikemnmn54u 174 8 order order NN work_7k7caouvh5efzjp7ikemnmn54u 174 9 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 174 10 for for IN work_7k7caouvh5efzjp7ikemnmn54u 174 11 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 174 12 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 174 13 . . . work_7k7caouvh5efzjp7ikemnmn54u 175 1 J. J. NNP work_7k7caouvh5efzjp7ikemnmn54u 175 2 Phys Phys NNP work_7k7caouvh5efzjp7ikemnmn54u 175 3 . . . work_7k7caouvh5efzjp7ikemnmn54u 176 1 Chem Chem NNP work_7k7caouvh5efzjp7ikemnmn54u 176 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 177 1 98 98 CD work_7k7caouvh5efzjp7ikemnmn54u 177 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 177 3 4940–4945 4940–4945 CD work_7k7caouvh5efzjp7ikemnmn54u 177 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 178 1 8 8 LS work_7k7caouvh5efzjp7ikemnmn54u 178 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 179 1 Hao Hao NNP work_7k7caouvh5efzjp7ikemnmn54u 179 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 179 3 M.-H. M.-H. NNP work_7k7caouvh5efzjp7ikemnmn54u 179 4 & & CC work_7k7caouvh5efzjp7ikemnmn54u 179 5 Scheraga Scheraga NNP work_7k7caouvh5efzjp7ikemnmn54u 179 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 179 7 H. H. NNP work_7k7caouvh5efzjp7ikemnmn54u 179 8 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 179 9 1994 1994 CD work_7k7caouvh5efzjp7ikemnmn54u 179 10 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 179 11 . . . work_7k7caouvh5efzjp7ikemnmn54u 180 1 Statistical statistical JJ work_7k7caouvh5efzjp7ikemnmn54u 180 2 thermodynamics thermodynamic NNS work_7k7caouvh5efzjp7ikemnmn54u 180 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 180 4 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 180 5 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 180 6 : : : work_7k7caouvh5efzjp7ikemnmn54u 180 7 sequence sequence NN work_7k7caouvh5efzjp7ikemnmn54u 180 8 dependence dependence NN work_7k7caouvh5efzjp7ikemnmn54u 180 9 . . . work_7k7caouvh5efzjp7ikemnmn54u 181 1 J. J. NNP work_7k7caouvh5efzjp7ikemnmn54u 181 2 Phys Phys NNP work_7k7caouvh5efzjp7ikemnmn54u 181 3 . . . work_7k7caouvh5efzjp7ikemnmn54u 182 1 Chem Chem NNP work_7k7caouvh5efzjp7ikemnmn54u 182 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 183 1 98 98 CD work_7k7caouvh5efzjp7ikemnmn54u 183 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 183 3 9882–9886 9882–9886 CD work_7k7caouvh5efzjp7ikemnmn54u 183 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 184 1 9 9 CD work_7k7caouvh5efzjp7ikemnmn54u 184 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 185 1 Guo Guo NNP work_7k7caouvh5efzjp7ikemnmn54u 185 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 185 3 Z. Z. NNP work_7k7caouvh5efzjp7ikemnmn54u 185 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 185 5 Thirumalai Thirumalai NNP work_7k7caouvh5efzjp7ikemnmn54u 185 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 185 7 D. D. NNP work_7k7caouvh5efzjp7ikemnmn54u 185 8 & & CC work_7k7caouvh5efzjp7ikemnmn54u 185 9 Honeycutt Honeycutt NNP work_7k7caouvh5efzjp7ikemnmn54u 185 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 185 11 J.D. J.D. NNP work_7k7caouvh5efzjp7ikemnmn54u 186 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 186 2 1992 1992 CD work_7k7caouvh5efzjp7ikemnmn54u 186 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 186 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 187 1 Folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 187 2 kinetics kinetic NNS work_7k7caouvh5efzjp7ikemnmn54u 187 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 187 4 proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 187 5 : : : work_7k7caouvh5efzjp7ikemnmn54u 187 6 a a DT work_7k7caouvh5efzjp7ikemnmn54u 187 7 model model NN work_7k7caouvh5efzjp7ikemnmn54u 187 8 study study NN work_7k7caouvh5efzjp7ikemnmn54u 187 9 . . . work_7k7caouvh5efzjp7ikemnmn54u 188 1 J. J. NNP work_7k7caouvh5efzjp7ikemnmn54u 188 2 Chem Chem NNP work_7k7caouvh5efzjp7ikemnmn54u 188 3 . . . work_7k7caouvh5efzjp7ikemnmn54u 189 1 Phys phys NN work_7k7caouvh5efzjp7ikemnmn54u 189 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 190 1 97 97 CD work_7k7caouvh5efzjp7ikemnmn54u 190 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 190 3 525–535 525–535 CD work_7k7caouvh5efzjp7ikemnmn54u 190 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 191 1 10 10 CD work_7k7caouvh5efzjp7ikemnmn54u 191 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 192 1 Abkevich Abkevich NNP work_7k7caouvh5efzjp7ikemnmn54u 192 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 192 3 V. V. NNP work_7k7caouvh5efzjp7ikemnmn54u 192 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 192 5 Gutin Gutin NNP work_7k7caouvh5efzjp7ikemnmn54u 192 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 192 7 A. a. NN work_7k7caouvh5efzjp7ikemnmn54u 193 1 & & CC work_7k7caouvh5efzjp7ikemnmn54u 193 2 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 193 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 193 4 E. E. NNP work_7k7caouvh5efzjp7ikemnmn54u 193 5 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 193 6 1994 1994 CD work_7k7caouvh5efzjp7ikemnmn54u 193 7 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 193 8 . . . work_7k7caouvh5efzjp7ikemnmn54u 194 1 Specific specific JJ work_7k7caouvh5efzjp7ikemnmn54u 194 2 nucleus nucleus NN work_7k7caouvh5efzjp7ikemnmn54u 194 3 as as IN work_7k7caouvh5efzjp7ikemnmn54u 194 4 the the DT work_7k7caouvh5efzjp7ikemnmn54u 194 5 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 194 6 state state NN work_7k7caouvh5efzjp7ikemnmn54u 194 7 for for IN work_7k7caouvh5efzjp7ikemnmn54u 194 8 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 194 9 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 194 10 : : : work_7k7caouvh5efzjp7ikemnmn54u 194 11 evidence evidence NN work_7k7caouvh5efzjp7ikemnmn54u 194 12 from from IN work_7k7caouvh5efzjp7ikemnmn54u 194 13 the the DT work_7k7caouvh5efzjp7ikemnmn54u 194 14 lattice lattice NN work_7k7caouvh5efzjp7ikemnmn54u 194 15 model model NN work_7k7caouvh5efzjp7ikemnmn54u 194 16 . . . work_7k7caouvh5efzjp7ikemnmn54u 195 1 Biochemistry Biochemistry NNP work_7k7caouvh5efzjp7ikemnmn54u 195 2 33 33 CD work_7k7caouvh5efzjp7ikemnmn54u 195 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 195 4 10026–10036 10026–10036 CD work_7k7caouvh5efzjp7ikemnmn54u 195 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 196 1 11 11 CD work_7k7caouvh5efzjp7ikemnmn54u 196 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 197 1 Karplus Karplus NNP work_7k7caouvh5efzjp7ikemnmn54u 197 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 197 3 M. M. NNP work_7k7caouvh5efzjp7ikemnmn54u 197 4 & & CC work_7k7caouvh5efzjp7ikemnmn54u 197 5 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 197 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 197 7 E. E. NNP work_7k7caouvh5efzjp7ikemnmn54u 197 8 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 197 9 1994 1994 CD work_7k7caouvh5efzjp7ikemnmn54u 197 10 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 197 11 . . . work_7k7caouvh5efzjp7ikemnmn54u 198 1 Protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 198 2 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 198 3 : : : work_7k7caouvh5efzjp7ikemnmn54u 198 4 theoretical theoretical JJ work_7k7caouvh5efzjp7ikemnmn54u 198 5 studies study NNS work_7k7caouvh5efzjp7ikemnmn54u 198 6 of of IN work_7k7caouvh5efzjp7ikemnmn54u 198 7 thermodynamics thermodynamic NNS work_7k7caouvh5efzjp7ikemnmn54u 198 8 and and CC work_7k7caouvh5efzjp7ikemnmn54u 198 9 dynamics dynamic NNS work_7k7caouvh5efzjp7ikemnmn54u 198 10 . . . work_7k7caouvh5efzjp7ikemnmn54u 199 1 In in IN work_7k7caouvh5efzjp7ikemnmn54u 199 2 Protein Protein NNP work_7k7caouvh5efzjp7ikemnmn54u 199 3 Folding Folding NNP work_7k7caouvh5efzjp7ikemnmn54u 199 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 200 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 200 2 Creighton Creighton NNP work_7k7caouvh5efzjp7ikemnmn54u 200 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 200 4 T. T. NNP work_7k7caouvh5efzjp7ikemnmn54u 200 5 , , , work_7k7caouvh5efzjp7ikemnmn54u 200 6 ed ed NNP work_7k7caouvh5efzjp7ikemnmn54u 200 7 . . . work_7k7caouvh5efzjp7ikemnmn54u 200 8 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 201 1 pp pp NNP work_7k7caouvh5efzjp7ikemnmn54u 201 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 202 1 127–196 127–196 CD work_7k7caouvh5efzjp7ikemnmn54u 202 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 202 3 W.H. W.H. NNP work_7k7caouvh5efzjp7ikemnmn54u 203 1 Freeman Freeman NNP work_7k7caouvh5efzjp7ikemnmn54u 203 2 and and CC work_7k7caouvh5efzjp7ikemnmn54u 203 3 Company Company NNP work_7k7caouvh5efzjp7ikemnmn54u 203 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 203 5 New New NNP work_7k7caouvh5efzjp7ikemnmn54u 203 6 York York NNP work_7k7caouvh5efzjp7ikemnmn54u 203 7 . . . work_7k7caouvh5efzjp7ikemnmn54u 204 1 12 12 CD work_7k7caouvh5efzjp7ikemnmn54u 204 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 205 1 Bryngelson Bryngelson NNP work_7k7caouvh5efzjp7ikemnmn54u 205 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 205 3 J. J. NNP work_7k7caouvh5efzjp7ikemnmn54u 205 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 205 5 Onuchic Onuchic NNP work_7k7caouvh5efzjp7ikemnmn54u 205 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 205 7 J.N. J.N. NNP work_7k7caouvh5efzjp7ikemnmn54u 205 8 , , , work_7k7caouvh5efzjp7ikemnmn54u 205 9 Socci Socci NNP work_7k7caouvh5efzjp7ikemnmn54u 205 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 205 11 N.D. North Dakota NNP work_7k7caouvh5efzjp7ikemnmn54u 205 12 & & CC work_7k7caouvh5efzjp7ikemnmn54u 205 13 Wolynes Wolynes NNP work_7k7caouvh5efzjp7ikemnmn54u 205 14 , , , work_7k7caouvh5efzjp7ikemnmn54u 205 15 P. P. NNP work_7k7caouvh5efzjp7ikemnmn54u 205 16 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 205 17 1995 1995 CD work_7k7caouvh5efzjp7ikemnmn54u 205 18 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 205 19 . . . work_7k7caouvh5efzjp7ikemnmn54u 206 1 Funnels funnel NNS work_7k7caouvh5efzjp7ikemnmn54u 206 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 206 3 pathways pathway NNS work_7k7caouvh5efzjp7ikemnmn54u 206 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 206 5 and and CC work_7k7caouvh5efzjp7ikemnmn54u 206 6 the the DT work_7k7caouvh5efzjp7ikemnmn54u 206 7 energy energy NN work_7k7caouvh5efzjp7ikemnmn54u 206 8 landscape landscape NN work_7k7caouvh5efzjp7ikemnmn54u 206 9 of of IN work_7k7caouvh5efzjp7ikemnmn54u 206 10 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 206 11 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 206 12 : : : work_7k7caouvh5efzjp7ikemnmn54u 206 13 a a DT work_7k7caouvh5efzjp7ikemnmn54u 206 14 syn- syn- JJ work_7k7caouvh5efzjp7ikemnmn54u 206 15 thesis thesis NN work_7k7caouvh5efzjp7ikemnmn54u 206 16 . . . work_7k7caouvh5efzjp7ikemnmn54u 207 1 Proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 207 2 21 21 CD work_7k7caouvh5efzjp7ikemnmn54u 207 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 207 4 167–195 167–195 CD work_7k7caouvh5efzjp7ikemnmn54u 207 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 208 1 13 13 CD work_7k7caouvh5efzjp7ikemnmn54u 208 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 209 1 Privalov Privalov NNP work_7k7caouvh5efzjp7ikemnmn54u 209 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 209 3 P.L. P.L. NNP work_7k7caouvh5efzjp7ikemnmn54u 210 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 210 2 1989 1989 CD work_7k7caouvh5efzjp7ikemnmn54u 210 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 210 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 211 1 Stability stability NN work_7k7caouvh5efzjp7ikemnmn54u 211 2 of of IN work_7k7caouvh5efzjp7ikemnmn54u 211 3 proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 211 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 212 1 I. I. NNP work_7k7caouvh5efzjp7ikemnmn54u 213 1 Small small JJ work_7k7caouvh5efzjp7ikemnmn54u 213 2 globular globular JJ work_7k7caouvh5efzjp7ikemnmn54u 213 3 proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 213 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 214 1 Annu Annu NNP work_7k7caouvh5efzjp7ikemnmn54u 214 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 215 1 Rev. Rev. NNP work_7k7caouvh5efzjp7ikemnmn54u 216 1 Biophys Biophys NNP work_7k7caouvh5efzjp7ikemnmn54u 216 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 217 1 Biophys Biophys NNP work_7k7caouvh5efzjp7ikemnmn54u 217 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 218 1 Chem Chem NNP work_7k7caouvh5efzjp7ikemnmn54u 218 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 219 1 18 18 CD work_7k7caouvh5efzjp7ikemnmn54u 219 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 219 3 47–69 47–69 NN work_7k7caouvh5efzjp7ikemnmn54u 219 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 220 1 14 14 CD work_7k7caouvh5efzjp7ikemnmn54u 220 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 221 1 Goldstein Goldstein NNP work_7k7caouvh5efzjp7ikemnmn54u 221 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 221 3 R. R. NNP work_7k7caouvh5efzjp7ikemnmn54u 221 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 221 5 Luthey Luthey NNP work_7k7caouvh5efzjp7ikemnmn54u 221 6 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 221 7 Schulten Schulten NNP work_7k7caouvh5efzjp7ikemnmn54u 221 8 , , , work_7k7caouvh5efzjp7ikemnmn54u 221 9 Z.A. Z.A. NNP work_7k7caouvh5efzjp7ikemnmn54u 222 1 & & CC work_7k7caouvh5efzjp7ikemnmn54u 222 2 Wolynes Wolynes NNP work_7k7caouvh5efzjp7ikemnmn54u 222 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 222 4 P. P. NNP work_7k7caouvh5efzjp7ikemnmn54u 222 5 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 222 6 1992 1992 CD work_7k7caouvh5efzjp7ikemnmn54u 222 7 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 222 8 . . . work_7k7caouvh5efzjp7ikemnmn54u 223 1 Optimal optimal JJ work_7k7caouvh5efzjp7ikemnmn54u 223 2 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 223 3 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 223 4 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 223 5 codes code NNS work_7k7caouvh5efzjp7ikemnmn54u 223 6 from from IN work_7k7caouvh5efzjp7ikemnmn54u 223 7 spin spin NN work_7k7caouvh5efzjp7ikemnmn54u 223 8 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 223 9 glass glass NN work_7k7caouvh5efzjp7ikemnmn54u 223 10 theory theory NN work_7k7caouvh5efzjp7ikemnmn54u 223 11 . . . work_7k7caouvh5efzjp7ikemnmn54u 224 1 Proc Proc NNP work_7k7caouvh5efzjp7ikemnmn54u 224 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 225 1 Natl Natl NNP work_7k7caouvh5efzjp7ikemnmn54u 225 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 226 1 Acad Acad NNS work_7k7caouvh5efzjp7ikemnmn54u 226 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 227 1 Sci Sci NNP work_7k7caouvh5efzjp7ikemnmn54u 227 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 228 1 USA USA NNP work_7k7caouvh5efzjp7ikemnmn54u 228 2 89 89 CD work_7k7caouvh5efzjp7ikemnmn54u 228 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 228 4 4918–4922 4918–4922 CD work_7k7caouvh5efzjp7ikemnmn54u 228 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 229 1 15 15 CD work_7k7caouvh5efzjp7ikemnmn54u 229 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 230 1 Abkevich Abkevich NNP work_7k7caouvh5efzjp7ikemnmn54u 230 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 230 3 V. V. NNP work_7k7caouvh5efzjp7ikemnmn54u 230 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 230 5 Gutin Gutin NNP work_7k7caouvh5efzjp7ikemnmn54u 230 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 230 7 A. a. NN work_7k7caouvh5efzjp7ikemnmn54u 231 1 & & CC work_7k7caouvh5efzjp7ikemnmn54u 231 2 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 231 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 231 4 E. E. NNP work_7k7caouvh5efzjp7ikemnmn54u 231 5 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 231 6 1995 1995 CD work_7k7caouvh5efzjp7ikemnmn54u 231 7 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 231 8 . . . work_7k7caouvh5efzjp7ikemnmn54u 232 1 Impact impact NN work_7k7caouvh5efzjp7ikemnmn54u 232 2 of of IN work_7k7caouvh5efzjp7ikemnmn54u 232 3 local local JJ work_7k7caouvh5efzjp7ikemnmn54u 232 4 and and CC work_7k7caouvh5efzjp7ikemnmn54u 232 5 non non JJ work_7k7caouvh5efzjp7ikemnmn54u 232 6 - - JJ work_7k7caouvh5efzjp7ikemnmn54u 232 7 local local JJ work_7k7caouvh5efzjp7ikemnmn54u 232 8 interactions interaction NNS work_7k7caouvh5efzjp7ikemnmn54u 232 9 on on IN work_7k7caouvh5efzjp7ikemnmn54u 232 10 thermodynamics thermodynamic NNS work_7k7caouvh5efzjp7ikemnmn54u 232 11 and and CC work_7k7caouvh5efzjp7ikemnmn54u 232 12 kinetics kinetic NNS work_7k7caouvh5efzjp7ikemnmn54u 232 13 of of IN work_7k7caouvh5efzjp7ikemnmn54u 232 14 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 232 15 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 232 16 . . . work_7k7caouvh5efzjp7ikemnmn54u 233 1 J. J. NNP work_7k7caouvh5efzjp7ikemnmn54u 233 2 Mol Mol NNP work_7k7caouvh5efzjp7ikemnmn54u 233 3 . . . work_7k7caouvh5efzjp7ikemnmn54u 234 1 Biol Biol NNP work_7k7caouvh5efzjp7ikemnmn54u 234 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 235 1 252 252 CD work_7k7caouvh5efzjp7ikemnmn54u 235 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 235 3 460–471 460–471 CD work_7k7caouvh5efzjp7ikemnmn54u 235 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 236 1 16 16 CD work_7k7caouvh5efzjp7ikemnmn54u 236 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 237 1 Landau Landau NNS work_7k7caouvh5efzjp7ikemnmn54u 237 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 237 3 L.D. L.D. NNP work_7k7caouvh5efzjp7ikemnmn54u 238 1 & & CC work_7k7caouvh5efzjp7ikemnmn54u 238 2 Lifshitz Lifshitz NNP work_7k7caouvh5efzjp7ikemnmn54u 238 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 238 4 E.M. E.M. NNP work_7k7caouvh5efzjp7ikemnmn54u 238 5 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 238 6 1980 1980 CD work_7k7caouvh5efzjp7ikemnmn54u 238 7 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 238 8 . . . work_7k7caouvh5efzjp7ikemnmn54u 239 1 Statistical Statistical NNP work_7k7caouvh5efzjp7ikemnmn54u 239 2 Physics Physics NNP work_7k7caouvh5efzjp7ikemnmn54u 239 3 . . . work_7k7caouvh5efzjp7ikemnmn54u 240 1 Pergamon Pergamon NNP work_7k7caouvh5efzjp7ikemnmn54u 240 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 240 3 London London NNP work_7k7caouvh5efzjp7ikemnmn54u 240 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 241 1 17 17 CD work_7k7caouvh5efzjp7ikemnmn54u 241 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 242 1 Poland Poland NNP work_7k7caouvh5efzjp7ikemnmn54u 242 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 242 3 D. D. NNP work_7k7caouvh5efzjp7ikemnmn54u 242 4 & & CC work_7k7caouvh5efzjp7ikemnmn54u 242 5 Scheraga Scheraga NNP work_7k7caouvh5efzjp7ikemnmn54u 242 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 242 7 H.A. H.A. NNP work_7k7caouvh5efzjp7ikemnmn54u 243 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 243 2 1970 1970 CD work_7k7caouvh5efzjp7ikemnmn54u 243 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 243 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 244 1 Theory theory NN work_7k7caouvh5efzjp7ikemnmn54u 244 2 of of IN work_7k7caouvh5efzjp7ikemnmn54u 244 3 Helix Helix NNP work_7k7caouvh5efzjp7ikemnmn54u 244 4 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 244 5 Coil Coil NNP work_7k7caouvh5efzjp7ikemnmn54u 244 6 Transitions Transitions NNPS work_7k7caouvh5efzjp7ikemnmn54u 244 7 in in IN work_7k7caouvh5efzjp7ikemnmn54u 244 8 Biopolymers Biopolymers NNPS work_7k7caouvh5efzjp7ikemnmn54u 244 9 . . . work_7k7caouvh5efzjp7ikemnmn54u 245 1 Academic Academic NNP work_7k7caouvh5efzjp7ikemnmn54u 245 2 Press Press NNP work_7k7caouvh5efzjp7ikemnmn54u 245 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 245 4 New New NNP work_7k7caouvh5efzjp7ikemnmn54u 245 5 York York NNP work_7k7caouvh5efzjp7ikemnmn54u 245 6 . . . work_7k7caouvh5efzjp7ikemnmn54u 246 1 18 18 CD work_7k7caouvh5efzjp7ikemnmn54u 246 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 247 1 Griko Griko NNP work_7k7caouvh5efzjp7ikemnmn54u 247 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 247 3 Y.V. Y.V. NNP work_7k7caouvh5efzjp7ikemnmn54u 248 1 & & CC work_7k7caouvh5efzjp7ikemnmn54u 248 2 Privalov Privalov NNP work_7k7caouvh5efzjp7ikemnmn54u 248 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 248 4 P.L. P.L. NNP work_7k7caouvh5efzjp7ikemnmn54u 249 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 249 2 1994 1994 CD work_7k7caouvh5efzjp7ikemnmn54u 249 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 249 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 250 1 Thermodynamic thermodynamic JJ work_7k7caouvh5efzjp7ikemnmn54u 250 2 puzzle puzzle NN work_7k7caouvh5efzjp7ikemnmn54u 250 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 250 4 apomyo- apomyo- NNP work_7k7caouvh5efzjp7ikemnmn54u 250 5 globin globin NNP work_7k7caouvh5efzjp7ikemnmn54u 250 6 unfolding unfold VBG work_7k7caouvh5efzjp7ikemnmn54u 250 7 . . . work_7k7caouvh5efzjp7ikemnmn54u 251 1 J. J. NNP work_7k7caouvh5efzjp7ikemnmn54u 251 2 Mol Mol NNP work_7k7caouvh5efzjp7ikemnmn54u 251 3 . . . work_7k7caouvh5efzjp7ikemnmn54u 252 1 Biol Biol NNP work_7k7caouvh5efzjp7ikemnmn54u 252 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 253 1 235 235 CD work_7k7caouvh5efzjp7ikemnmn54u 253 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 253 3 1318–1325 1318–1325 CD work_7k7caouvh5efzjp7ikemnmn54u 253 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 254 1 19 19 CD work_7k7caouvh5efzjp7ikemnmn54u 254 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 255 1 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 255 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 255 3 E. E. NNP work_7k7caouvh5efzjp7ikemnmn54u 255 4 & & CC work_7k7caouvh5efzjp7ikemnmn54u 255 5 Gutin Gutin NNP work_7k7caouvh5efzjp7ikemnmn54u 255 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 255 7 A. a. NN work_7k7caouvh5efzjp7ikemnmn54u 256 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 256 2 1993 1993 CD work_7k7caouvh5efzjp7ikemnmn54u 256 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 256 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 257 1 Engineering engineering NN work_7k7caouvh5efzjp7ikemnmn54u 257 2 of of IN work_7k7caouvh5efzjp7ikemnmn54u 257 3 stable stable JJ work_7k7caouvh5efzjp7ikemnmn54u 257 4 and and CC work_7k7caouvh5efzjp7ikemnmn54u 257 5 fast- fast- JJ work_7k7caouvh5efzjp7ikemnmn54u 257 6 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 257 7 sequences sequence NNS work_7k7caouvh5efzjp7ikemnmn54u 257 8 of of IN work_7k7caouvh5efzjp7ikemnmn54u 257 9 model model NN work_7k7caouvh5efzjp7ikemnmn54u 257 10 proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 257 11 . . . work_7k7caouvh5efzjp7ikemnmn54u 258 1 Proc Proc NNP work_7k7caouvh5efzjp7ikemnmn54u 258 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 259 1 Natl Natl NNP work_7k7caouvh5efzjp7ikemnmn54u 259 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 260 1 Acad Acad NNS work_7k7caouvh5efzjp7ikemnmn54u 260 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 261 1 Sci Sci NNP work_7k7caouvh5efzjp7ikemnmn54u 261 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 262 1 USA USA NNP work_7k7caouvh5efzjp7ikemnmn54u 262 2 90 90 CD work_7k7caouvh5efzjp7ikemnmn54u 262 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 262 4 7195–7199 7195–7199 CD work_7k7caouvh5efzjp7ikemnmn54u 262 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 263 1 20 20 CD work_7k7caouvh5efzjp7ikemnmn54u 263 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 264 1 Ramanathan Ramanathan NNP work_7k7caouvh5efzjp7ikemnmn54u 264 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 264 3 S. S. NNP work_7k7caouvh5efzjp7ikemnmn54u 264 4 & & CC work_7k7caouvh5efzjp7ikemnmn54u 264 5 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 264 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 264 7 E. E. NNP work_7k7caouvh5efzjp7ikemnmn54u 264 8 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 264 9 1994 1994 CD work_7k7caouvh5efzjp7ikemnmn54u 264 10 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 264 11 . . . work_7k7caouvh5efzjp7ikemnmn54u 265 1 Statistical statistical JJ work_7k7caouvh5efzjp7ikemnmn54u 265 2 mechanics mechanic NNS work_7k7caouvh5efzjp7ikemnmn54u 265 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 265 4 proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 265 5 with with IN work_7k7caouvh5efzjp7ikemnmn54u 265 6 “ " `` work_7k7caouvh5efzjp7ikemnmn54u 265 7 evolutionary evolutionary JJ work_7k7caouvh5efzjp7ikemnmn54u 265 8 selected select VBN work_7k7caouvh5efzjp7ikemnmn54u 265 9 ” " '' work_7k7caouvh5efzjp7ikemnmn54u 265 10 sequences sequence NNS work_7k7caouvh5efzjp7ikemnmn54u 265 11 . . . work_7k7caouvh5efzjp7ikemnmn54u 266 1 Phys phys NN work_7k7caouvh5efzjp7ikemnmn54u 266 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 267 1 Rev. Rev. NNP work_7k7caouvh5efzjp7ikemnmn54u 268 1 E E NNP work_7k7caouvh5efzjp7ikemnmn54u 268 2 50 50 CD work_7k7caouvh5efzjp7ikemnmn54u 268 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 268 4 1303–1312 1303–1312 CD work_7k7caouvh5efzjp7ikemnmn54u 268 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 269 1 21 21 CD work_7k7caouvh5efzjp7ikemnmn54u 269 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 270 1 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 270 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 270 3 E. E. NNP work_7k7caouvh5efzjp7ikemnmn54u 270 4 & & CC work_7k7caouvh5efzjp7ikemnmn54u 270 5 Gutin Gutin NNP work_7k7caouvh5efzjp7ikemnmn54u 270 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 270 7 A.M. A.M. NNP work_7k7caouvh5efzjp7ikemnmn54u 270 8 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 270 9 1989 1989 CD work_7k7caouvh5efzjp7ikemnmn54u 270 10 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 270 11 . . . work_7k7caouvh5efzjp7ikemnmn54u 271 1 Formation formation NN work_7k7caouvh5efzjp7ikemnmn54u 271 2 of of IN work_7k7caouvh5efzjp7ikemnmn54u 271 3 unique unique JJ work_7k7caouvh5efzjp7ikemnmn54u 271 4 structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 271 5 in in IN work_7k7caouvh5efzjp7ikemnmn54u 271 6 polypeptide polypeptide NN work_7k7caouvh5efzjp7ikemnmn54u 271 7 chains chain NNS work_7k7caouvh5efzjp7ikemnmn54u 271 8 . . . work_7k7caouvh5efzjp7ikemnmn54u 272 1 Theoretical theoretical JJ work_7k7caouvh5efzjp7ikemnmn54u 272 2 investigation investigation NN work_7k7caouvh5efzjp7ikemnmn54u 272 3 with with IN work_7k7caouvh5efzjp7ikemnmn54u 272 4 the the DT work_7k7caouvh5efzjp7ikemnmn54u 272 5 aid aid NN work_7k7caouvh5efzjp7ikemnmn54u 272 6 of of IN work_7k7caouvh5efzjp7ikemnmn54u 272 7 replica replica NNP work_7k7caouvh5efzjp7ikemnmn54u 272 8 approach approach NN work_7k7caouvh5efzjp7ikemnmn54u 272 9 . . . work_7k7caouvh5efzjp7ikemnmn54u 273 1 Biophys Biophys NNP work_7k7caouvh5efzjp7ikemnmn54u 273 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 274 1 Chem Chem NNP work_7k7caouvh5efzjp7ikemnmn54u 274 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 275 1 34 34 CD work_7k7caouvh5efzjp7ikemnmn54u 275 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 275 3 187–199 187–199 CD work_7k7caouvh5efzjp7ikemnmn54u 275 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 276 1 22 22 CD work_7k7caouvh5efzjp7ikemnmn54u 276 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 277 1 Chaffotte chaffotte NN work_7k7caouvh5efzjp7ikemnmn54u 277 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 277 3 A. a. NN work_7k7caouvh5efzjp7ikemnmn54u 277 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 277 5 Guillou Guillou NNP work_7k7caouvh5efzjp7ikemnmn54u 277 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 277 7 Y. Y. NNP work_7k7caouvh5efzjp7ikemnmn54u 278 1 & & CC work_7k7caouvh5efzjp7ikemnmn54u 278 2 Goldberg Goldberg NNP work_7k7caouvh5efzjp7ikemnmn54u 278 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 278 4 M. M. NNP work_7k7caouvh5efzjp7ikemnmn54u 278 5 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 278 6 1992 1992 CD work_7k7caouvh5efzjp7ikemnmn54u 278 7 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 278 8 . . . work_7k7caouvh5efzjp7ikemnmn54u 279 1 Biochemistry Biochemistry NNP work_7k7caouvh5efzjp7ikemnmn54u 279 2 31 31 CD work_7k7caouvh5efzjp7ikemnmn54u 279 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 279 4 9694–9702 9694–9702 CD work_7k7caouvh5efzjp7ikemnmn54u 279 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 280 1 23 23 CD work_7k7caouvh5efzjp7ikemnmn54u 280 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 281 1 Davidson Davidson NNP work_7k7caouvh5efzjp7ikemnmn54u 281 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 281 3 A. a. NN work_7k7caouvh5efzjp7ikemnmn54u 282 1 & & CC work_7k7caouvh5efzjp7ikemnmn54u 282 2 Sauer Sauer NNP work_7k7caouvh5efzjp7ikemnmn54u 282 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 282 4 R. R. NNP work_7k7caouvh5efzjp7ikemnmn54u 282 5 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 282 6 1994 1994 CD work_7k7caouvh5efzjp7ikemnmn54u 282 7 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 282 8 . . . work_7k7caouvh5efzjp7ikemnmn54u 283 1 Folded fold VBN work_7k7caouvh5efzjp7ikemnmn54u 283 2 proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 283 3 occur occur VBP work_7k7caouvh5efzjp7ikemnmn54u 283 4 frequently frequently RB work_7k7caouvh5efzjp7ikemnmn54u 283 5 in in IN work_7k7caouvh5efzjp7ikemnmn54u 283 6 libraries library NNS work_7k7caouvh5efzjp7ikemnmn54u 283 7 of of IN work_7k7caouvh5efzjp7ikemnmn54u 283 8 random random JJ work_7k7caouvh5efzjp7ikemnmn54u 283 9 amino amino JJ work_7k7caouvh5efzjp7ikemnmn54u 283 10 acid acid NN work_7k7caouvh5efzjp7ikemnmn54u 283 11 sequences sequence NNS work_7k7caouvh5efzjp7ikemnmn54u 283 12 . . . work_7k7caouvh5efzjp7ikemnmn54u 284 1 Proc Proc NNP work_7k7caouvh5efzjp7ikemnmn54u 284 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 285 1 Natl Natl NNP work_7k7caouvh5efzjp7ikemnmn54u 285 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 286 1 Acad Acad NNS work_7k7caouvh5efzjp7ikemnmn54u 286 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 287 1 Sci Sci NNP work_7k7caouvh5efzjp7ikemnmn54u 287 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 288 1 USA USA NNP work_7k7caouvh5efzjp7ikemnmn54u 288 2 91 91 CD work_7k7caouvh5efzjp7ikemnmn54u 288 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 288 4 2146–2150 2146–2150 CD work_7k7caouvh5efzjp7ikemnmn54u 288 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 289 1 24 24 CD work_7k7caouvh5efzjp7ikemnmn54u 289 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 290 1 Gutin Gutin NNP work_7k7caouvh5efzjp7ikemnmn54u 290 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 290 3 A. a. NN work_7k7caouvh5efzjp7ikemnmn54u 290 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 290 5 Abkevich Abkevich NNP work_7k7caouvh5efzjp7ikemnmn54u 290 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 290 7 V. V. NNP work_7k7caouvh5efzjp7ikemnmn54u 290 8 & & CC work_7k7caouvh5efzjp7ikemnmn54u 290 9 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 290 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 290 11 E. E. NNP work_7k7caouvh5efzjp7ikemnmn54u 290 12 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 290 13 1995 1995 CD work_7k7caouvh5efzjp7ikemnmn54u 290 14 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 290 15 . . . work_7k7caouvh5efzjp7ikemnmn54u 291 1 Is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 291 2 burst burst VBN work_7k7caouvh5efzjp7ikemnmn54u 291 3 hydrophobic hydrophobic JJ work_7k7caouvh5efzjp7ikemnmn54u 291 4 collapse collapse NN work_7k7caouvh5efzjp7ikemnmn54u 291 5 necessary necessary JJ work_7k7caouvh5efzjp7ikemnmn54u 291 6 for for IN work_7k7caouvh5efzjp7ikemnmn54u 291 7 rapid rapid JJ work_7k7caouvh5efzjp7ikemnmn54u 291 8 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 291 9 ? ? . work_7k7caouvh5efzjp7ikemnmn54u 292 1 Biochemistry Biochemistry NNP work_7k7caouvh5efzjp7ikemnmn54u 292 2 34 34 CD work_7k7caouvh5efzjp7ikemnmn54u 292 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 292 4 3066–3076 3066–3076 CD work_7k7caouvh5efzjp7ikemnmn54u 292 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 293 1 25 25 CD work_7k7caouvh5efzjp7ikemnmn54u 293 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 294 1 Makhatadze Makhatadze NNP work_7k7caouvh5efzjp7ikemnmn54u 294 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 294 3 G. G. NNP work_7k7caouvh5efzjp7ikemnmn54u 294 4 & & CC work_7k7caouvh5efzjp7ikemnmn54u 294 5 Privalov Privalov NNP work_7k7caouvh5efzjp7ikemnmn54u 294 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 294 7 P.L. P.L. NNP work_7k7caouvh5efzjp7ikemnmn54u 295 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 295 2 1995 1995 CD work_7k7caouvh5efzjp7ikemnmn54u 295 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 295 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 296 1 Energetics Energetics NNP work_7k7caouvh5efzjp7ikemnmn54u 296 2 of of IN work_7k7caouvh5efzjp7ikemnmn54u 296 3 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 296 4 struc- struc- XX work_7k7caouvh5efzjp7ikemnmn54u 296 5 ture ture NN work_7k7caouvh5efzjp7ikemnmn54u 296 6 . . . work_7k7caouvh5efzjp7ikemnmn54u 297 1 Adv Adv NNP work_7k7caouvh5efzjp7ikemnmn54u 297 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 298 1 Protein Protein NNP work_7k7caouvh5efzjp7ikemnmn54u 298 2 Chem Chem NNP work_7k7caouvh5efzjp7ikemnmn54u 298 3 . . . work_7k7caouvh5efzjp7ikemnmn54u 299 1 47 47 CD work_7k7caouvh5efzjp7ikemnmn54u 299 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 299 3 307–425 307–425 CD work_7k7caouvh5efzjp7ikemnmn54u 299 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 300 1 26 26 CD work_7k7caouvh5efzjp7ikemnmn54u 300 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 301 1 Honig Honig NNP work_7k7caouvh5efzjp7ikemnmn54u 301 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 301 3 B. B. NNP work_7k7caouvh5efzjp7ikemnmn54u 301 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 301 5 & & CC work_7k7caouvh5efzjp7ikemnmn54u 301 6 Yang Yang NNP work_7k7caouvh5efzjp7ikemnmn54u 301 7 , , , work_7k7caouvh5efzjp7ikemnmn54u 301 8 A.S. A.S. NNP work_7k7caouvh5efzjp7ikemnmn54u 301 9 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 301 10 1995 1995 CD work_7k7caouvh5efzjp7ikemnmn54u 301 11 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 301 12 . . . work_7k7caouvh5efzjp7ikemnmn54u 302 1 Free free JJ work_7k7caouvh5efzjp7ikemnmn54u 302 2 energy energy NN work_7k7caouvh5efzjp7ikemnmn54u 302 3 balance balance NN work_7k7caouvh5efzjp7ikemnmn54u 302 4 in in IN work_7k7caouvh5efzjp7ikemnmn54u 302 5 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 302 6 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 302 7 . . . work_7k7caouvh5efzjp7ikemnmn54u 303 1 Adv Adv NNP work_7k7caouvh5efzjp7ikemnmn54u 303 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 304 1 Protein Protein NNP work_7k7caouvh5efzjp7ikemnmn54u 304 2 Chem Chem NNP work_7k7caouvh5efzjp7ikemnmn54u 304 3 . . . work_7k7caouvh5efzjp7ikemnmn54u 305 1 46 46 CD work_7k7caouvh5efzjp7ikemnmn54u 305 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 305 3 27–58 27–58 CD work_7k7caouvh5efzjp7ikemnmn54u 305 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 306 1 27 27 CD work_7k7caouvh5efzjp7ikemnmn54u 306 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 307 1 Kiefhaber Kiefhaber NNP work_7k7caouvh5efzjp7ikemnmn54u 307 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 307 3 T. T. NNP work_7k7caouvh5efzjp7ikemnmn54u 307 4 & & CC work_7k7caouvh5efzjp7ikemnmn54u 307 5 Baldwin Baldwin NNP work_7k7caouvh5efzjp7ikemnmn54u 307 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 307 7 R. R. NNP work_7k7caouvh5efzjp7ikemnmn54u 307 8 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 307 9 1995 1995 CD work_7k7caouvh5efzjp7ikemnmn54u 307 10 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 307 11 . . . work_7k7caouvh5efzjp7ikemnmn54u 308 1 Kinetic Kinetic NNP work_7k7caouvh5efzjp7ikemnmn54u 308 2 of of IN work_7k7caouvh5efzjp7ikemnmn54u 308 3 hydrogen hydrogen NN work_7k7caouvh5efzjp7ikemnmn54u 308 4 bond bond NN work_7k7caouvh5efzjp7ikemnmn54u 308 5 breakage breakage NN work_7k7caouvh5efzjp7ikemnmn54u 308 6 in in IN work_7k7caouvh5efzjp7ikemnmn54u 308 7 the the DT work_7k7caouvh5efzjp7ikemnmn54u 308 8 process process NN work_7k7caouvh5efzjp7ikemnmn54u 308 9 of of IN work_7k7caouvh5efzjp7ikemnmn54u 308 10 ribonuclease ribonuclease NN work_7k7caouvh5efzjp7ikemnmn54u 308 11 a a DT work_7k7caouvh5efzjp7ikemnmn54u 308 12 measured measure VBN work_7k7caouvh5efzjp7ikemnmn54u 308 13 by by IN work_7k7caouvh5efzjp7ikemnmn54u 308 14 pulsed pulsed JJ work_7k7caouvh5efzjp7ikemnmn54u 308 15 hydrogen hydrogen NNP work_7k7caouvh5efzjp7ikemnmn54u 308 16 exchange exchange NN work_7k7caouvh5efzjp7ikemnmn54u 308 17 . . . work_7k7caouvh5efzjp7ikemnmn54u 309 1 Proc Proc NNP work_7k7caouvh5efzjp7ikemnmn54u 309 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 310 1 Natl Natl NNP work_7k7caouvh5efzjp7ikemnmn54u 310 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 311 1 Acad Acad NNS work_7k7caouvh5efzjp7ikemnmn54u 311 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 312 1 Sci Sci NNP work_7k7caouvh5efzjp7ikemnmn54u 312 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 313 1 USA USA NNP work_7k7caouvh5efzjp7ikemnmn54u 313 2 92 92 CD work_7k7caouvh5efzjp7ikemnmn54u 313 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 313 4 2657–2661 2657–2661 CD work_7k7caouvh5efzjp7ikemnmn54u 313 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 314 1 28 28 CD work_7k7caouvh5efzjp7ikemnmn54u 314 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 315 1 Kiefhaber Kiefhaber NNP work_7k7caouvh5efzjp7ikemnmn54u 315 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 315 3 T. T. NNP work_7k7caouvh5efzjp7ikemnmn54u 315 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 315 5 Labhardt Labhardt NNP work_7k7caouvh5efzjp7ikemnmn54u 315 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 315 7 A.M. A.M. NNP work_7k7caouvh5efzjp7ikemnmn54u 315 8 & & CC work_7k7caouvh5efzjp7ikemnmn54u 315 9 Baldwin Baldwin NNP work_7k7caouvh5efzjp7ikemnmn54u 315 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 315 11 R. R. NNP work_7k7caouvh5efzjp7ikemnmn54u 315 12 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 315 13 1995 1995 CD work_7k7caouvh5efzjp7ikemnmn54u 315 14 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 315 15 . . . work_7k7caouvh5efzjp7ikemnmn54u 316 1 Direct direct JJ work_7k7caouvh5efzjp7ikemnmn54u 316 2 NMR NMR NNP work_7k7caouvh5efzjp7ikemnmn54u 316 3 evi- evi- VBZ work_7k7caouvh5efzjp7ikemnmn54u 316 4 dence dence NN work_7k7caouvh5efzjp7ikemnmn54u 316 5 for for IN work_7k7caouvh5efzjp7ikemnmn54u 316 6 an an DT work_7k7caouvh5efzjp7ikemnmn54u 316 7 intermediate intermediate JJ work_7k7caouvh5efzjp7ikemnmn54u 316 8 preceding precede VBG work_7k7caouvh5efzjp7ikemnmn54u 316 9 the the DT work_7k7caouvh5efzjp7ikemnmn54u 316 10 rate rate NN work_7k7caouvh5efzjp7ikemnmn54u 316 11 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 316 12 limiting limit VBG work_7k7caouvh5efzjp7ikemnmn54u 316 13 step step NN work_7k7caouvh5efzjp7ikemnmn54u 316 14 in in IN work_7k7caouvh5efzjp7ikemnmn54u 316 15 the the DT work_7k7caouvh5efzjp7ikemnmn54u 316 16 unfolding unfolding NN work_7k7caouvh5efzjp7ikemnmn54u 316 17 of of IN work_7k7caouvh5efzjp7ikemnmn54u 316 18 ribonuclease ribonuclease NN work_7k7caouvh5efzjp7ikemnmn54u 316 19 A. a. NN work_7k7caouvh5efzjp7ikemnmn54u 317 1 Nature nature NN work_7k7caouvh5efzjp7ikemnmn54u 317 2 375 375 CD work_7k7caouvh5efzjp7ikemnmn54u 317 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 317 4 513–515 513–515 CD work_7k7caouvh5efzjp7ikemnmn54u 317 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 318 1 29 29 CD work_7k7caouvh5efzjp7ikemnmn54u 318 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 319 1 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 319 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 319 3 E. E. NNP work_7k7caouvh5efzjp7ikemnmn54u 319 4 & & CC work_7k7caouvh5efzjp7ikemnmn54u 319 5 Finkelstein Finkelstein NNP work_7k7caouvh5efzjp7ikemnmn54u 319 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 319 7 A.V. A.V. NNP work_7k7caouvh5efzjp7ikemnmn54u 320 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 320 2 1989 1989 CD work_7k7caouvh5efzjp7ikemnmn54u 320 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 320 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 321 1 Theory theory NN work_7k7caouvh5efzjp7ikemnmn54u 321 2 of of IN work_7k7caouvh5efzjp7ikemnmn54u 321 3 cooperative cooperative JJ work_7k7caouvh5efzjp7ikemnmn54u 321 4 tran- tran- NN work_7k7caouvh5efzjp7ikemnmn54u 321 5 sitions sition NNS work_7k7caouvh5efzjp7ikemnmn54u 321 6 in in IN work_7k7caouvh5efzjp7ikemnmn54u 321 7 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 321 8 molecules molecule NNS work_7k7caouvh5efzjp7ikemnmn54u 321 9 . . . work_7k7caouvh5efzjp7ikemnmn54u 322 1 I. I. NNP work_7k7caouvh5efzjp7ikemnmn54u 323 1 Why why WRB work_7k7caouvh5efzjp7ikemnmn54u 323 2 denaturation denaturation NN work_7k7caouvh5efzjp7ikemnmn54u 323 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 323 4 globular globular JJ work_7k7caouvh5efzjp7ikemnmn54u 323 5 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 323 6 is be VBZ work_7k7caouvh5efzjp7ikemnmn54u 323 7 a a DT work_7k7caouvh5efzjp7ikemnmn54u 323 8 first first JJ work_7k7caouvh5efzjp7ikemnmn54u 323 9 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 323 10 order order NN work_7k7caouvh5efzjp7ikemnmn54u 323 11 phase phase NN work_7k7caouvh5efzjp7ikemnmn54u 323 12 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 323 13 . . . work_7k7caouvh5efzjp7ikemnmn54u 324 1 Biopolymers biopolymer NNS work_7k7caouvh5efzjp7ikemnmn54u 324 2 28 28 CD work_7k7caouvh5efzjp7ikemnmn54u 324 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 324 4 1667–1681 1667–1681 CD work_7k7caouvh5efzjp7ikemnmn54u 324 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 325 1 30 30 CD work_7k7caouvh5efzjp7ikemnmn54u 325 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 326 1 Matouschek Matouschek NNP work_7k7caouvh5efzjp7ikemnmn54u 326 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 326 3 A. A. NNP work_7k7caouvh5efzjp7ikemnmn54u 326 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 326 5 Kellis Kellis NNP work_7k7caouvh5efzjp7ikemnmn54u 326 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 326 7 J. J. NNP work_7k7caouvh5efzjp7ikemnmn54u 326 8 Jr. Jr. NNP work_7k7caouvh5efzjp7ikemnmn54u 326 9 , , , work_7k7caouvh5efzjp7ikemnmn54u 326 10 Serrano Serrano NNP work_7k7caouvh5efzjp7ikemnmn54u 326 11 , , , work_7k7caouvh5efzjp7ikemnmn54u 326 12 L. L. NNP work_7k7caouvh5efzjp7ikemnmn54u 326 13 , , , work_7k7caouvh5efzjp7ikemnmn54u 326 14 Bycroft Bycroft NNP work_7k7caouvh5efzjp7ikemnmn54u 326 15 , , , work_7k7caouvh5efzjp7ikemnmn54u 326 16 M. M. NNP work_7k7caouvh5efzjp7ikemnmn54u 326 17 & & CC work_7k7caouvh5efzjp7ikemnmn54u 326 18 Fersht Fersht NNP work_7k7caouvh5efzjp7ikemnmn54u 326 19 , , , work_7k7caouvh5efzjp7ikemnmn54u 326 20 A.R. A.R. NNP work_7k7caouvh5efzjp7ikemnmn54u 327 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 327 2 1990 1990 CD work_7k7caouvh5efzjp7ikemnmn54u 327 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 327 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 328 1 Transient transient JJ work_7k7caouvh5efzjp7ikemnmn54u 328 2 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 328 3 intermediates intermediate NNS work_7k7caouvh5efzjp7ikemnmn54u 328 4 characterized characterize VBN work_7k7caouvh5efzjp7ikemnmn54u 328 5 by by IN work_7k7caouvh5efzjp7ikemnmn54u 328 6 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 328 7 engi- engi- XX work_7k7caouvh5efzjp7ikemnmn54u 328 8 neering neering NN work_7k7caouvh5efzjp7ikemnmn54u 328 9 . . . work_7k7caouvh5efzjp7ikemnmn54u 329 1 Nature nature NN work_7k7caouvh5efzjp7ikemnmn54u 329 2 346 346 CD work_7k7caouvh5efzjp7ikemnmn54u 329 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 329 4 440–445 440–445 CD work_7k7caouvh5efzjp7ikemnmn54u 329 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 330 1 31 31 CD work_7k7caouvh5efzjp7ikemnmn54u 330 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 331 1 Jackson Jackson NNP work_7k7caouvh5efzjp7ikemnmn54u 331 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 331 3 S.E. S.E. NNP work_7k7caouvh5efzjp7ikemnmn54u 331 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 331 5 elMasry elMasry NNP work_7k7caouvh5efzjp7ikemnmn54u 331 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 331 7 N. N. NNP work_7k7caouvh5efzjp7ikemnmn54u 331 8 & & CC work_7k7caouvh5efzjp7ikemnmn54u 331 9 Fersht Fersht NNP work_7k7caouvh5efzjp7ikemnmn54u 331 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 331 11 A.R. A.R. NNP work_7k7caouvh5efzjp7ikemnmn54u 332 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 332 2 1993 1993 CD work_7k7caouvh5efzjp7ikemnmn54u 332 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 332 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 333 1 Structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 333 2 of of IN work_7k7caouvh5efzjp7ikemnmn54u 333 3 the the DT work_7k7caouvh5efzjp7ikemnmn54u 333 4 hydrophobic hydrophobic JJ work_7k7caouvh5efzjp7ikemnmn54u 333 5 core core NN work_7k7caouvh5efzjp7ikemnmn54u 333 6 in in IN work_7k7caouvh5efzjp7ikemnmn54u 333 7 the the DT work_7k7caouvh5efzjp7ikemnmn54u 333 8 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 333 9 state state NN work_7k7caouvh5efzjp7ikemnmn54u 333 10 for for IN work_7k7caouvh5efzjp7ikemnmn54u 333 11 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 333 12 of of IN work_7k7caouvh5efzjp7ikemnmn54u 333 13 chymotrypsin chymotrypsin NNP work_7k7caouvh5efzjp7ikemnmn54u 333 14 inhibitor inhibitor NN work_7k7caouvh5efzjp7ikemnmn54u 333 15 2 2 CD work_7k7caouvh5efzjp7ikemnmn54u 333 16 : : : work_7k7caouvh5efzjp7ikemnmn54u 333 17 a a DT work_7k7caouvh5efzjp7ikemnmn54u 333 18 critical critical JJ work_7k7caouvh5efzjp7ikemnmn54u 333 19 test test NN work_7k7caouvh5efzjp7ikemnmn54u 333 20 of of IN work_7k7caouvh5efzjp7ikemnmn54u 333 21 the the DT work_7k7caouvh5efzjp7ikemnmn54u 333 22 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 333 23 engineering engineering NN work_7k7caouvh5efzjp7ikemnmn54u 333 24 method method NN work_7k7caouvh5efzjp7ikemnmn54u 333 25 of of IN work_7k7caouvh5efzjp7ikemnmn54u 333 26 analysis analysis NN work_7k7caouvh5efzjp7ikemnmn54u 333 27 . . . work_7k7caouvh5efzjp7ikemnmn54u 334 1 Biochemistry Biochemistry NNP work_7k7caouvh5efzjp7ikemnmn54u 334 2 32 32 CD work_7k7caouvh5efzjp7ikemnmn54u 334 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 334 4 11270–11278 11270–11278 CD work_7k7caouvh5efzjp7ikemnmn54u 334 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 335 1 32 32 CD work_7k7caouvh5efzjp7ikemnmn54u 335 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 336 1 Itzhaki Itzhaki NNP work_7k7caouvh5efzjp7ikemnmn54u 336 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 336 3 L. L. NNP work_7k7caouvh5efzjp7ikemnmn54u 336 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 336 5 Otzen Otzen NNP work_7k7caouvh5efzjp7ikemnmn54u 336 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 336 7 D. D. NNP work_7k7caouvh5efzjp7ikemnmn54u 336 8 & & CC work_7k7caouvh5efzjp7ikemnmn54u 336 9 Fersht Fersht NNP work_7k7caouvh5efzjp7ikemnmn54u 336 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 336 11 A. a. NN work_7k7caouvh5efzjp7ikemnmn54u 337 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 337 2 1995 1995 CD work_7k7caouvh5efzjp7ikemnmn54u 337 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 337 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 338 1 The the DT work_7k7caouvh5efzjp7ikemnmn54u 338 2 structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 338 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 338 4 the the DT work_7k7caouvh5efzjp7ikemnmn54u 338 5 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 338 6 state state NN work_7k7caouvh5efzjp7ikemnmn54u 338 7 for for IN work_7k7caouvh5efzjp7ikemnmn54u 338 8 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 338 9 of of IN work_7k7caouvh5efzjp7ikemnmn54u 338 10 chymotrypsin chymotrypsin NNP work_7k7caouvh5efzjp7ikemnmn54u 338 11 inhibitor inhibitor NN work_7k7caouvh5efzjp7ikemnmn54u 338 12 2 2 CD work_7k7caouvh5efzjp7ikemnmn54u 338 13 analyzed analyze VBN work_7k7caouvh5efzjp7ikemnmn54u 338 14 by by IN work_7k7caouvh5efzjp7ikemnmn54u 338 15 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 338 16 engi- engi- PRP$ work_7k7caouvh5efzjp7ikemnmn54u 338 17 neering neere VBG work_7k7caouvh5efzjp7ikemnmn54u 338 18 methods method NNS work_7k7caouvh5efzjp7ikemnmn54u 338 19 : : : work_7k7caouvh5efzjp7ikemnmn54u 338 20 evidence evidence NN work_7k7caouvh5efzjp7ikemnmn54u 338 21 for for IN work_7k7caouvh5efzjp7ikemnmn54u 338 22 a a DT work_7k7caouvh5efzjp7ikemnmn54u 338 23 nucleation nucleation NN work_7k7caouvh5efzjp7ikemnmn54u 338 24 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 338 25 condensation condensation NN work_7k7caouvh5efzjp7ikemnmn54u 338 26 mechanism mechanism NN work_7k7caouvh5efzjp7ikemnmn54u 338 27 for for IN work_7k7caouvh5efzjp7ikemnmn54u 338 28 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 338 29 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 338 30 . . . work_7k7caouvh5efzjp7ikemnmn54u 339 1 J. J. NNP work_7k7caouvh5efzjp7ikemnmn54u 339 2 Mol Mol NNP work_7k7caouvh5efzjp7ikemnmn54u 339 3 . . . work_7k7caouvh5efzjp7ikemnmn54u 340 1 Biol Biol NNP work_7k7caouvh5efzjp7ikemnmn54u 340 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 341 1 254 254 CD work_7k7caouvh5efzjp7ikemnmn54u 341 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 341 3 260–288 260–288 CD work_7k7caouvh5efzjp7ikemnmn54u 341 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 342 1 33 33 CD work_7k7caouvh5efzjp7ikemnmn54u 342 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 343 1 Creighton Creighton NNP work_7k7caouvh5efzjp7ikemnmn54u 343 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 343 3 T. T. NNP work_7k7caouvh5efzjp7ikemnmn54u 343 4 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 343 5 1992 1992 CD work_7k7caouvh5efzjp7ikemnmn54u 343 6 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 343 7 . . . work_7k7caouvh5efzjp7ikemnmn54u 344 1 Proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 344 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 345 1 Structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 345 2 and and CC work_7k7caouvh5efzjp7ikemnmn54u 345 3 Molecular Molecular NNP work_7k7caouvh5efzjp7ikemnmn54u 345 4 Properties Properties NNPS work_7k7caouvh5efzjp7ikemnmn54u 345 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 346 1 W.H. W.H. NNP work_7k7caouvh5efzjp7ikemnmn54u 347 1 Freeman Freeman NNP work_7k7caouvh5efzjp7ikemnmn54u 347 2 & & CC work_7k7caouvh5efzjp7ikemnmn54u 347 3 Co Co NNP work_7k7caouvh5efzjp7ikemnmn54u 347 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 347 5 New New NNP work_7k7caouvh5efzjp7ikemnmn54u 347 6 York York NNP work_7k7caouvh5efzjp7ikemnmn54u 347 7 . . . work_7k7caouvh5efzjp7ikemnmn54u 348 1 34 34 CD work_7k7caouvh5efzjp7ikemnmn54u 348 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 349 1 Schildbach Schildbach NNP work_7k7caouvh5efzjp7ikemnmn54u 349 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 349 3 J. J. NNP work_7k7caouvh5efzjp7ikemnmn54u 349 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 349 5 Milla Milla NNP work_7k7caouvh5efzjp7ikemnmn54u 349 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 349 7 M. M. NNP work_7k7caouvh5efzjp7ikemnmn54u 349 8 , , , work_7k7caouvh5efzjp7ikemnmn54u 349 9 Jeffrey Jeffrey NNP work_7k7caouvh5efzjp7ikemnmn54u 349 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 349 11 P. P. NNP work_7k7caouvh5efzjp7ikemnmn54u 349 12 , , , work_7k7caouvh5efzjp7ikemnmn54u 349 13 Raumann Raumann NNP work_7k7caouvh5efzjp7ikemnmn54u 349 14 , , , work_7k7caouvh5efzjp7ikemnmn54u 349 15 B. B. NNP work_7k7caouvh5efzjp7ikemnmn54u 350 1 & & CC work_7k7caouvh5efzjp7ikemnmn54u 350 2 Sauer Sauer NNP work_7k7caouvh5efzjp7ikemnmn54u 350 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 350 4 R. R. NNP work_7k7caouvh5efzjp7ikemnmn54u 350 5 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 350 6 1995 1995 CD work_7k7caouvh5efzjp7ikemnmn54u 350 7 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 350 8 . . . work_7k7caouvh5efzjp7ikemnmn54u 351 1 Crystal crystal NN work_7k7caouvh5efzjp7ikemnmn54u 351 2 structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 351 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 351 4 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 351 5 and and CC work_7k7caouvh5efzjp7ikemnmn54u 351 6 operator operator NN work_7k7caouvh5efzjp7ikemnmn54u 351 7 binding binding NN work_7k7caouvh5efzjp7ikemnmn54u 351 8 of of IN work_7k7caouvh5efzjp7ikemnmn54u 351 9 the the DT work_7k7caouvh5efzjp7ikemnmn54u 351 10 hyperstable hyperstable JJ work_7k7caouvh5efzjp7ikemnmn54u 351 11 arc arc NN work_7k7caouvh5efzjp7ikemnmn54u 351 12 repressor repressor NNP work_7k7caouvh5efzjp7ikemnmn54u 351 13 mutant mutant JJ work_7k7caouvh5efzjp7ikemnmn54u 351 14 PL8 PL8 NNP work_7k7caouvh5efzjp7ikemnmn54u 351 15 . . . work_7k7caouvh5efzjp7ikemnmn54u 352 1 Biochemistry Biochemistry NNP work_7k7caouvh5efzjp7ikemnmn54u 352 2 34 34 CD work_7k7caouvh5efzjp7ikemnmn54u 352 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 352 4 1405–1412 1405–1412 CD work_7k7caouvh5efzjp7ikemnmn54u 352 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 353 1 35 35 CD work_7k7caouvh5efzjp7ikemnmn54u 353 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 354 1 Milla Milla NNP work_7k7caouvh5efzjp7ikemnmn54u 354 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 354 3 M. M. NNP work_7k7caouvh5efzjp7ikemnmn54u 354 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 354 5 Braun Braun NNP work_7k7caouvh5efzjp7ikemnmn54u 354 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 354 7 R. R. NNP work_7k7caouvh5efzjp7ikemnmn54u 354 8 , , , work_7k7caouvh5efzjp7ikemnmn54u 354 9 Walburger Walburger NNP work_7k7caouvh5efzjp7ikemnmn54u 354 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 354 11 C. C. NNP work_7k7caouvh5efzjp7ikemnmn54u 354 12 & & CC work_7k7caouvh5efzjp7ikemnmn54u 354 13 Sauer Sauer NNP work_7k7caouvh5efzjp7ikemnmn54u 354 14 , , , work_7k7caouvh5efzjp7ikemnmn54u 354 15 R. R. NNP work_7k7caouvh5efzjp7ikemnmn54u 354 16 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 354 17 1995 1995 CD work_7k7caouvh5efzjp7ikemnmn54u 354 18 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 354 19 . . . work_7k7caouvh5efzjp7ikemnmn54u 355 1 P22 P22 NNP work_7k7caouvh5efzjp7ikemnmn54u 355 2 arc arc NNP work_7k7caouvh5efzjp7ikemnmn54u 355 3 repres- repres- VBZ work_7k7caouvh5efzjp7ikemnmn54u 355 4 sor sor NN work_7k7caouvh5efzjp7ikemnmn54u 355 5 : : : work_7k7caouvh5efzjp7ikemnmn54u 355 6 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 355 7 state state NN work_7k7caouvh5efzjp7ikemnmn54u 355 8 properties property NNS work_7k7caouvh5efzjp7ikemnmn54u 355 9 inferred infer VBN work_7k7caouvh5efzjp7ikemnmn54u 355 10 from from IN work_7k7caouvh5efzjp7ikemnmn54u 355 11 mutational mutational JJ work_7k7caouvh5efzjp7ikemnmn54u 355 12 effects effect NNS work_7k7caouvh5efzjp7ikemnmn54u 355 13 on on IN work_7k7caouvh5efzjp7ikemnmn54u 355 14 the the DT work_7k7caouvh5efzjp7ikemnmn54u 355 15 rates rate NNS work_7k7caouvh5efzjp7ikemnmn54u 355 16 of of IN work_7k7caouvh5efzjp7ikemnmn54u 355 17 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 355 18 unfolding unfold VBG work_7k7caouvh5efzjp7ikemnmn54u 355 19 and and CC work_7k7caouvh5efzjp7ikemnmn54u 355 20 refolding refolde VBG work_7k7caouvh5efzjp7ikemnmn54u 355 21 . . . work_7k7caouvh5efzjp7ikemnmn54u 356 1 Biochemistry Biochemistry NNP work_7k7caouvh5efzjp7ikemnmn54u 356 2 34 34 CD work_7k7caouvh5efzjp7ikemnmn54u 356 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 356 4 13914–13919 13914–13919 CD work_7k7caouvh5efzjp7ikemnmn54u 356 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 357 1 36 36 CD work_7k7caouvh5efzjp7ikemnmn54u 357 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 358 1 López López NNP work_7k7caouvh5efzjp7ikemnmn54u 358 2 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 358 3 Hernández Hernández NNP work_7k7caouvh5efzjp7ikemnmn54u 358 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 358 5 E. E. NNP work_7k7caouvh5efzjp7ikemnmn54u 358 6 & & CC work_7k7caouvh5efzjp7ikemnmn54u 358 7 Serrano Serrano NNP work_7k7caouvh5efzjp7ikemnmn54u 358 8 , , , work_7k7caouvh5efzjp7ikemnmn54u 358 9 L. L. NNP work_7k7caouvh5efzjp7ikemnmn54u 358 10 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 358 11 1996 1996 CD work_7k7caouvh5efzjp7ikemnmn54u 358 12 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 358 13 . . . work_7k7caouvh5efzjp7ikemnmn54u 359 1 Structure structure NN work_7k7caouvh5efzjp7ikemnmn54u 359 2 of of IN work_7k7caouvh5efzjp7ikemnmn54u 359 3 the the DT work_7k7caouvh5efzjp7ikemnmn54u 359 4 transition transition NN work_7k7caouvh5efzjp7ikemnmn54u 359 5 state state NN work_7k7caouvh5efzjp7ikemnmn54u 359 6 for for IN work_7k7caouvh5efzjp7ikemnmn54u 359 7 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 359 8 of of IN work_7k7caouvh5efzjp7ikemnmn54u 359 9 the the DT work_7k7caouvh5efzjp7ikemnmn54u 359 10 129 129 CD work_7k7caouvh5efzjp7ikemnmn54u 359 11 aa aa NNP work_7k7caouvh5efzjp7ikemnmn54u 359 12 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 359 13 CheY CheY NNP work_7k7caouvh5efzjp7ikemnmn54u 359 14 resembles resemble VBZ work_7k7caouvh5efzjp7ikemnmn54u 359 15 that that IN work_7k7caouvh5efzjp7ikemnmn54u 359 16 of of IN work_7k7caouvh5efzjp7ikemnmn54u 359 17 a a DT work_7k7caouvh5efzjp7ikemnmn54u 359 18 smaller small JJR work_7k7caouvh5efzjp7ikemnmn54u 359 19 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 359 20 , , , work_7k7caouvh5efzjp7ikemnmn54u 359 21 CI-2 CI-2 NNP work_7k7caouvh5efzjp7ikemnmn54u 359 22 . . . work_7k7caouvh5efzjp7ikemnmn54u 360 1 Folding Folding NNP work_7k7caouvh5efzjp7ikemnmn54u 360 2 & & CC work_7k7caouvh5efzjp7ikemnmn54u 360 3 Design Design NNP work_7k7caouvh5efzjp7ikemnmn54u 360 4 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 360 5 , , , work_7k7caouvh5efzjp7ikemnmn54u 360 6 43–55 43–55 CD work_7k7caouvh5efzjp7ikemnmn54u 360 7 . . . work_7k7caouvh5efzjp7ikemnmn54u 361 1 Review review VB work_7k7caouvh5efzjp7ikemnmn54u 361 2 Modeling Modeling NNP work_7k7caouvh5efzjp7ikemnmn54u 361 3 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 361 4 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 361 5 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 361 6 R53 R53 NNP work_7k7caouvh5efzjp7ikemnmn54u 361 7 37 37 CD work_7k7caouvh5efzjp7ikemnmn54u 361 8 . . . work_7k7caouvh5efzjp7ikemnmn54u 362 1 Sosnick Sosnick NNP work_7k7caouvh5efzjp7ikemnmn54u 362 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 362 3 T. T. NNP work_7k7caouvh5efzjp7ikemnmn54u 362 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 362 5 Jackson Jackson NNP work_7k7caouvh5efzjp7ikemnmn54u 362 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 362 7 S. S. NNP work_7k7caouvh5efzjp7ikemnmn54u 362 8 , , , work_7k7caouvh5efzjp7ikemnmn54u 362 9 Englander Englander NNP work_7k7caouvh5efzjp7ikemnmn54u 362 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 362 11 S.W. S.W. NNP work_7k7caouvh5efzjp7ikemnmn54u 363 1 & & CC work_7k7caouvh5efzjp7ikemnmn54u 363 2 DeGrado DeGrado NNP work_7k7caouvh5efzjp7ikemnmn54u 363 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 363 4 W. W. NNP work_7k7caouvh5efzjp7ikemnmn54u 363 5 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 363 6 1996 1996 CD work_7k7caouvh5efzjp7ikemnmn54u 363 7 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 363 8 . . . work_7k7caouvh5efzjp7ikemnmn54u 364 1 The the DT work_7k7caouvh5efzjp7ikemnmn54u 364 2 role role NN work_7k7caouvh5efzjp7ikemnmn54u 364 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 364 4 helix helix JJ work_7k7caouvh5efzjp7ikemnmn54u 364 5 formation formation NN work_7k7caouvh5efzjp7ikemnmn54u 364 6 in in IN work_7k7caouvh5efzjp7ikemnmn54u 364 7 the the DT work_7k7caouvh5efzjp7ikemnmn54u 364 8 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 364 9 of of IN work_7k7caouvh5efzjp7ikemnmn54u 364 10 a a DT work_7k7caouvh5efzjp7ikemnmn54u 364 11 fully fully RB work_7k7caouvh5efzjp7ikemnmn54u 364 12 � � JJ work_7k7caouvh5efzjp7ikemnmn54u 364 13 -helical -helical JJ work_7k7caouvh5efzjp7ikemnmn54u 364 14 coiled coil VBN work_7k7caouvh5efzjp7ikemnmn54u 364 15 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 364 16 coil coil NN work_7k7caouvh5efzjp7ikemnmn54u 364 17 . . . work_7k7caouvh5efzjp7ikemnmn54u 365 1 Pro- pro- NN work_7k7caouvh5efzjp7ikemnmn54u 365 2 teins tein VBZ work_7k7caouvh5efzjp7ikemnmn54u 365 3 24 24 CD work_7k7caouvh5efzjp7ikemnmn54u 365 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 365 5 427–432 427–432 CD work_7k7caouvh5efzjp7ikemnmn54u 365 6 . . . work_7k7caouvh5efzjp7ikemnmn54u 366 1 38 38 CD work_7k7caouvh5efzjp7ikemnmn54u 366 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 367 1 Sosnick Sosnick NNP work_7k7caouvh5efzjp7ikemnmn54u 367 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 367 3 T.R. T.R. NNP work_7k7caouvh5efzjp7ikemnmn54u 367 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 367 5 Mayne Mayne NNP work_7k7caouvh5efzjp7ikemnmn54u 367 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 367 7 L. L. NNP work_7k7caouvh5efzjp7ikemnmn54u 367 8 & & CC work_7k7caouvh5efzjp7ikemnmn54u 367 9 Englander Englander NNP work_7k7caouvh5efzjp7ikemnmn54u 367 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 367 11 S.W. S.W. NNP work_7k7caouvh5efzjp7ikemnmn54u 368 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 368 2 1996 1996 CD work_7k7caouvh5efzjp7ikemnmn54u 368 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 368 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 369 1 Molecular molecular JJ work_7k7caouvh5efzjp7ikemnmn54u 369 2 col- col- JJ work_7k7caouvh5efzjp7ikemnmn54u 369 3 lapse lapse NN work_7k7caouvh5efzjp7ikemnmn54u 369 4 : : : work_7k7caouvh5efzjp7ikemnmn54u 369 5 the the DT work_7k7caouvh5efzjp7ikemnmn54u 369 6 rate rate NN work_7k7caouvh5efzjp7ikemnmn54u 369 7 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 369 8 limiting limit VBG work_7k7caouvh5efzjp7ikemnmn54u 369 9 step step NN work_7k7caouvh5efzjp7ikemnmn54u 369 10 in in IN work_7k7caouvh5efzjp7ikemnmn54u 369 11 two two CD work_7k7caouvh5efzjp7ikemnmn54u 369 12 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 369 13 state state NN work_7k7caouvh5efzjp7ikemnmn54u 369 14 cytochrome cytochrome NN work_7k7caouvh5efzjp7ikemnmn54u 369 15 C c NN work_7k7caouvh5efzjp7ikemnmn54u 369 16 folding fold VBG work_7k7caouvh5efzjp7ikemnmn54u 369 17 . . . work_7k7caouvh5efzjp7ikemnmn54u 370 1 Pro- pro- NN work_7k7caouvh5efzjp7ikemnmn54u 370 2 teins tein NNS work_7k7caouvh5efzjp7ikemnmn54u 370 3 24 24 CD work_7k7caouvh5efzjp7ikemnmn54u 370 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 370 5 413–426 413–426 CD work_7k7caouvh5efzjp7ikemnmn54u 370 6 . . . work_7k7caouvh5efzjp7ikemnmn54u 371 1 39 39 CD work_7k7caouvh5efzjp7ikemnmn54u 371 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 372 1 Shakhnovich Shakhnovich NNP work_7k7caouvh5efzjp7ikemnmn54u 372 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 372 3 E. E. NNP work_7k7caouvh5efzjp7ikemnmn54u 372 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 372 5 Abkevich Abkevich NNP work_7k7caouvh5efzjp7ikemnmn54u 372 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 372 7 V. V. NNP work_7k7caouvh5efzjp7ikemnmn54u 372 8 & & CC work_7k7caouvh5efzjp7ikemnmn54u 372 9 Ptitsyn Ptitsyn NNP work_7k7caouvh5efzjp7ikemnmn54u 372 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 372 11 O. O. NNP work_7k7caouvh5efzjp7ikemnmn54u 373 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 373 2 1996 1996 CD work_7k7caouvh5efzjp7ikemnmn54u 373 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 373 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 374 1 Conserved conserved JJ work_7k7caouvh5efzjp7ikemnmn54u 374 2 residues residue NNS work_7k7caouvh5efzjp7ikemnmn54u 374 3 and and CC work_7k7caouvh5efzjp7ikemnmn54u 374 4 the the DT work_7k7caouvh5efzjp7ikemnmn54u 374 5 mechanism mechanism NN work_7k7caouvh5efzjp7ikemnmn54u 374 6 of of IN work_7k7caouvh5efzjp7ikemnmn54u 374 7 protein protein NN work_7k7caouvh5efzjp7ikemnmn54u 374 8 folding folding NN work_7k7caouvh5efzjp7ikemnmn54u 374 9 . . . work_7k7caouvh5efzjp7ikemnmn54u 375 1 Nature nature NN work_7k7caouvh5efzjp7ikemnmn54u 375 2 379 379 CD work_7k7caouvh5efzjp7ikemnmn54u 375 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 375 4 96–98 96–98 CD work_7k7caouvh5efzjp7ikemnmn54u 375 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 376 1 40 40 CD work_7k7caouvh5efzjp7ikemnmn54u 376 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 377 1 Ingwall Ingwall NNP work_7k7caouvh5efzjp7ikemnmn54u 377 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 377 3 R. R. NNP work_7k7caouvh5efzjp7ikemnmn54u 377 4 , , , work_7k7caouvh5efzjp7ikemnmn54u 377 5 Scheraga Scheraga NNP work_7k7caouvh5efzjp7ikemnmn54u 377 6 , , , work_7k7caouvh5efzjp7ikemnmn54u 377 7 H. H. NNP work_7k7caouvh5efzjp7ikemnmn54u 377 8 , , , work_7k7caouvh5efzjp7ikemnmn54u 377 9 Lotan Lotan NNP work_7k7caouvh5efzjp7ikemnmn54u 377 10 , , , work_7k7caouvh5efzjp7ikemnmn54u 377 11 N. N. NNP work_7k7caouvh5efzjp7ikemnmn54u 377 12 , , , work_7k7caouvh5efzjp7ikemnmn54u 377 13 Berger Berger NNP work_7k7caouvh5efzjp7ikemnmn54u 377 14 , , , work_7k7caouvh5efzjp7ikemnmn54u 377 15 A. a. NN work_7k7caouvh5efzjp7ikemnmn54u 378 1 & & CC work_7k7caouvh5efzjp7ikemnmn54u 378 2 Katchalski Katchalski NNP work_7k7caouvh5efzjp7ikemnmn54u 378 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 378 4 E. E. NNP work_7k7caouvh5efzjp7ikemnmn54u 378 5 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 378 6 1968 1968 CD work_7k7caouvh5efzjp7ikemnmn54u 378 7 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 378 8 . . . work_7k7caouvh5efzjp7ikemnmn54u 379 1 Conformational conformational JJ work_7k7caouvh5efzjp7ikemnmn54u 379 2 studies study NNS work_7k7caouvh5efzjp7ikemnmn54u 379 3 of of IN work_7k7caouvh5efzjp7ikemnmn54u 379 4 poly poly JJ work_7k7caouvh5efzjp7ikemnmn54u 379 5 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 379 6 L l NN work_7k7caouvh5efzjp7ikemnmn54u 379 7 - - HYPH work_7k7caouvh5efzjp7ikemnmn54u 379 8 alanine alanine NN work_7k7caouvh5efzjp7ikemnmn54u 379 9 in in IN work_7k7caouvh5efzjp7ikemnmn54u 379 10 water water NN work_7k7caouvh5efzjp7ikemnmn54u 379 11 . . . work_7k7caouvh5efzjp7ikemnmn54u 380 1 Biopolymers biopolymer NNS work_7k7caouvh5efzjp7ikemnmn54u 380 2 6 6 CD work_7k7caouvh5efzjp7ikemnmn54u 380 3 , , , work_7k7caouvh5efzjp7ikemnmn54u 380 4 331–368 331–368 CD work_7k7caouvh5efzjp7ikemnmn54u 380 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 381 1 41 41 CD work_7k7caouvh5efzjp7ikemnmn54u 381 2 . . . work_7k7caouvh5efzjp7ikemnmn54u 382 1 Brooks Brooks NNP work_7k7caouvh5efzjp7ikemnmn54u 382 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 382 3 C. C. NNP work_7k7caouvh5efzjp7ikemnmn54u 382 4 III III NNP work_7k7caouvh5efzjp7ikemnmn54u 382 5 , , , work_7k7caouvh5efzjp7ikemnmn54u 382 6 Karplus Karplus NNP work_7k7caouvh5efzjp7ikemnmn54u 382 7 , , , work_7k7caouvh5efzjp7ikemnmn54u 382 8 M. M. NNP work_7k7caouvh5efzjp7ikemnmn54u 382 9 & & CC work_7k7caouvh5efzjp7ikemnmn54u 382 10 Petitt Petitt NNP work_7k7caouvh5efzjp7ikemnmn54u 382 11 , , , work_7k7caouvh5efzjp7ikemnmn54u 382 12 B. B. NNP work_7k7caouvh5efzjp7ikemnmn54u 383 1 ( ( -LRB- work_7k7caouvh5efzjp7ikemnmn54u 383 2 1988 1988 CD work_7k7caouvh5efzjp7ikemnmn54u 383 3 ) ) -RRB- work_7k7caouvh5efzjp7ikemnmn54u 383 4 . . . work_7k7caouvh5efzjp7ikemnmn54u 384 1 Proteins protein NNS work_7k7caouvh5efzjp7ikemnmn54u 384 2 : : : work_7k7caouvh5efzjp7ikemnmn54u 384 3 a a DT work_7k7caouvh5efzjp7ikemnmn54u 384 4 Theoretical Theoretical NNP work_7k7caouvh5efzjp7ikemnmn54u 384 5 Perspective Perspective NNP work_7k7caouvh5efzjp7ikemnmn54u 384 6 on on IN work_7k7caouvh5efzjp7ikemnmn54u 384 7 Dynamics Dynamics NNP work_7k7caouvh5efzjp7ikemnmn54u 384 8 , , , work_7k7caouvh5efzjp7ikemnmn54u 384 9 Structure Structure NNP work_7k7caouvh5efzjp7ikemnmn54u 384 10 and and CC work_7k7caouvh5efzjp7ikemnmn54u 384 11 Thermodynamics Thermodynamics NNP work_7k7caouvh5efzjp7ikemnmn54u 384 12 . . . work_7k7caouvh5efzjp7ikemnmn54u 385 1 Wiley Wiley NNP work_7k7caouvh5efzjp7ikemnmn54u 385 2 , , , work_7k7caouvh5efzjp7ikemnmn54u 385 3 New New NNP work_7k7caouvh5efzjp7ikemnmn54u 385 4 York York NNP work_7k7caouvh5efzjp7ikemnmn54u 385 5 . . . work_7k7caouvh5efzjp7ikemnmn54u 386 1 R54 R54 NNP work_7k7caouvh5efzjp7ikemnmn54u 386 2 Folding Folding NNP work_7k7caouvh5efzjp7ikemnmn54u 386 3 & & CC work_7k7caouvh5efzjp7ikemnmn54u 386 4 Design Design NNP work_7k7caouvh5efzjp7ikemnmn54u 386 5 Vol Vol NNP work_7k7caouvh5efzjp7ikemnmn54u 386 6 1 1 CD work_7k7caouvh5efzjp7ikemnmn54u 386 7 No no DT work_7k7caouvh5efzjp7ikemnmn54u 386 8 3 3 CD work_7k7caouvh5efzjp7ikemnmn54u 386 9 Discussion Discussion NNP work_7k7caouvh5efzjp7ikemnmn54u 386 10 pages page NNS work_7k7caouvh5efzjp7ikemnmn54u 386 11 relevant relevant JJ work_7k7caouvh5efzjp7ikemnmn54u 386 12 to to IN work_7k7caouvh5efzjp7ikemnmn54u 386 13 this this DT work_7k7caouvh5efzjp7ikemnmn54u 386 14 article article NN work_7k7caouvh5efzjp7ikemnmn54u 386 15 are be VBP work_7k7caouvh5efzjp7ikemnmn54u 386 16 now now RB work_7k7caouvh5efzjp7ikemnmn54u 386 17 available available JJ work_7k7caouvh5efzjp7ikemnmn54u 386 18 from from IN work_7k7caouvh5efzjp7ikemnmn54u 386 19 the the DT work_7k7caouvh5efzjp7ikemnmn54u 386 20 Folding Folding NNP work_7k7caouvh5efzjp7ikemnmn54u 386 21 & & CC work_7k7caouvh5efzjp7ikemnmn54u 386 22 Design Design NNP work_7k7caouvh5efzjp7ikemnmn54u 386 23 gateway gateway NN work_7k7caouvh5efzjp7ikemnmn54u 386 24 page page NN work_7k7caouvh5efzjp7ikemnmn54u 386 25 within within IN work_7k7caouvh5efzjp7ikemnmn54u 386 26 the the DT work_7k7caouvh5efzjp7ikemnmn54u 386 27 BioMedNet BioMedNet NNP work_7k7caouvh5efzjp7ikemnmn54u 386 28 at at IN work_7k7caouvh5efzjp7ikemnmn54u 386 29 http://BioMedNet.com/cbiology/fad.htm http://BioMedNet.com/cbiology/fad.htm NNP