Sleeping beauty transposition from nonintegrating lentivirus. | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1038/mt.2009.94 Corpus ID: 205204954Sleeping beauty transposition from nonintegrating lentivirus. @article{Vink2009SleepingBT, title={Sleeping beauty transposition from nonintegrating lentivirus.}, author={C. Vink and H. Gaspar and R. Gabriel and M. Schmidt and R. McIvor and Adrian J Thrasher and W. Qasim}, journal={Molecular therapy : the journal of the American Society of Gene Therapy}, year={2009}, volume={17 7}, pages={ 1197-204 } } C. Vink, H. Gaspar, +4 authors W. Qasim Published 2009 Biology, Medicine Molecular therapy : the journal of the American Society of Gene Therapy Lentiviral vectors enter cells with high efficiency and deliver stable transduction through integration into host chromosomes, but their preference for integration within actively transcribing genes means that insertional mutagenesis following disruption of host proto-oncogenes is a recognized concern. We have addressed this problem by combining the efficient cell and nuclear entry properties of HIV-1-derived lentiviral vectors with the integration profile benefits of Sleeping Beauty (SB… Expand View on PubMed doi.org Save to Library Create Alert Cite Launch Research Feed Share This Paper 77 CitationsHighly Influential Citations 3 Background Citations 21 Methods Citations 11 Results Citations 3 View All Figures and Topics from this paper figure 1 figure 2 figure 3 figure 4 figure 5 View All 5 Figures & Tables Long Terminal Repeat Transposase Integrase benefit Chromosomes Terminal Repeat Sequences Proto-Oncogenes Subfamily lentivirinae transduction Inverted Papilloma 77 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells. Brian Moldt, C. Miskey, +8 authors J. Mikkelsen Biology, Medicine Molecular therapy : the journal of the American Society of Gene Therapy 2011 67 Save Alert Research Feed A hybrid lentivirus-transposon vector for safer gene therapy C. Vink Biology 2010 1 PDF Save Alert Research Feed Mobilization of DNA transposable elements from lentiviral vectors R. Bak, J. Mikkelsen Medicine Mobile genetic elements 2011 4 Save Alert Research Feed Transcriptionally regulated and nontoxic delivery of the hyperactive Sleeping Beauty Transposase Fabienne Cocchiarella, M. Latella, +4 authors A. Recchia Biology, Medicine Molecular therapy. Methods & clinical development 2016 2 Save Alert Research Feed Hybrid lentiviral vectors. W. Qasim, C. Vink, A. Thrasher Biology, Medicine Molecular therapy : the journal of the American Society of Gene Therapy 2010 11 Save Alert Research Feed Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery M. Galla, A. Schambach, +10 authors C. Baum Medicine Nucleic acids research 2011 50 PDF View 1 excerpt, cites results Save Alert Research Feed Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery Melanie Galla, A. Schambach, +10 authors C. Baum Biology Nucleic Acids Research 2012 2 PDF Save Alert Research Feed Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration W. Zhang, Martin Muck-Hausl, +6 authors A. Ehrhardt Biology, Medicine PloS one 2013 27 PDF Save Alert Research Feed Development of the hybrid Sleeping Beauty-baculovirus vector for sustained gene expression and cancer therapy W-Y Luo, Y-S Shih, +8 authors Y-C Hu Biology, Medicine Gene Therapy 2012 46 PDF Save Alert Research Feed Understanding lentiviral vector chromatin targeting: working to reduce insertional mutagenic potential for gene therapy C. Papayannakos, R. Daniel Biology, Medicine Gene Therapy 2013 33 PDF Save Alert Research Feed ... 1 2 3 4 5 ... References SHOWING 1-10 OF 38 REFERENCES SORT BYRelevance Most Influenced Papers Recency Stable gene transfer to muscle using non-integrating lentiviral vectors. L. Apolonia, S. Waddington, +6 authors N. Philpott Biology, Medicine Molecular therapy : the journal of the American Society of Gene Therapy 2007 163 PDF Save Alert Research Feed Hybrid lentivirus-transposon vectors with a random integration profile in human cells. N. Staunstrup, Brian Moldt, +5 authors J. Mikkelsen Biology, Medicine Molecular therapy : the journal of the American Society of Gene Therapy 2009 99 Save Alert Research Feed Helper-Independent Sleeping Beauty transposon-transposase vectors for efficient nonviral gene delivery and persistent gene expression in vivo. J. Mikkelsen, S. Yant, L. Meuse, Z. Huang, H. Xu, M. 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