Black Skin and the Ideal of Beauty VOL. 108 . NO . M AY t 9Y7 Table I. Microsatellite Instability in Neurofibromas of Two Related NF-l Patients" Marke rs T1 T2 T3 T4 D2S 1 23 + 0 9S 1 26 + + + 0 9S1 96 + + D9S 2 87 + 09S176 + + D9S 12 7 + a Thre e nc urofi bro m Bs oC th e fat h e r (T I. T 2 . T 3) and onc of th e d aug hte r (T4) were anal y z e d at 23 1l1i cros<1 cclli tc lo c i . Altered mi c ro satc llitc l1l;lrkc rs are shown . sug g ests that this ge n e tic ev ent m ay b e ch ara cte ri sti c o f tb e late stages of tumor d evelo pm ent. On th e other hand , th e in cr eas ed susceptibility to e n vironm ental facto rs, pro ba bl y inv o lve d in n e u- rofi broma tumOli ge n es is, ma y al so ex pl ain di fie re n ces b e tw ee n individuals . M ultipl e ge n es r esp o nsibl e fo r se ve ral ge n o de rma toses ha ve be en recentl y m appe d on chromo so m e 9 (Pe ri cak-Van ce ef ai , 1995 ). Ou r findin g o f multiple alterations o n chro m oso m e 9 indi cates that " m o difying ge n es" (Easton et ai, 199 3) , unlinked to th e NF- 1 loc u s an d loca ted in th e r egio n s w e anal yze d , mi ght ha ve a r ole it) th e path ogen esis of n e uro fibr o ma s in NF-l pati e nts. F urth e r in ves ti ga- LETTERS T O T HE ED ITOR 813 tio n s o n a large r numb er of N F-l p atients ar e n ee d ed to claJ.i fy th e p rec is e rol e o f chro m oso m e 9 in th e d eve lo pm en t of th ese tumors . M ali a Con cett a Farg n oli , Sergio C himen ti , Ke t ty Pelis D ep artm ent of Derm ato logy Unive rsity of L' Aq uil a, L' A quil a, Ital y REFER E N CES Easto n DF, Po de r MA . Hu so n SM , Po n de r HAJ: An alla lys is ofv;lriauon in exp ress io n of n c u fo fibro m :tcosis (N F) ryp e 1. (NF l ): ev idence fo r m od ifyi n g gcn es . .4 111 J HUIII Cm et 53:305- 31 3, t 993 H on chel R . Hallin g KC , Pitte lkow M. Sch aid OJ, T hi bod eau SN : M icrosa telli rc in s t ~lbiljry in M uir-Torre syndro m e . Gnll re,. Res 5 -1: l t 59 -1 '163 . J 99-t H Oll c hc1 It . H all ing K C . Thi bo d eau SN : Gen o m ic in sti1b ility in I1 co pla sin. Scmill Cel l Bioi 6:45-52 . 1995 Ottini L. Espo siro D L, R.ic he l ta A. Cn rl csil1l o M. P" llll.iro tra R. Veri M C. Bat ti sfa P. f rad L. Ca rami a fG. C alv ic ri S, C,lm a A, Mariani- C o stan tin i It: Al te rn tion s o f m ic rosatc lli ces in ne u roftb ro m as o f VOlI R cc kJin g<1 u sc ll 's d ise ase . C allce,. Res 55:5677- 5680. 1995 Pe ricak - Va nc e MA . Ba le AE, H aine s JL, Kwiarko w ski D.I . Pil z A , Slau gc nh au pt S , W hite j A. Edward s jH . Ma rc hu k O. Olopa de 0 1. Attwoo d .l , Povey S: R.epo rt o n the fo urth w o rksho p a ll c hro m o so m c 9 . A IIII H I/III G elll'l 59:3 -1- 7- 36 5 , 1995 Pc ris K. Ke ll e r G , C him c n ti S. A m