id author title date pages extension mime words sentences flesch summary cache txt 10_1101-2020_12_31_424989 Hojjatian, Alimohammad Distinct cryo-EM Structure of α-synuclein Filaments derived by Tau 2021 24 .pdf application/pdf 7945 801 58 Distinct cryo-EM Structure of α-synuclein Filaments derived by Tau report structural characterizations of -synuclein filaments derived by a potential co-factor, tau, However, the Nand C-terminal regions of the tau-promoted -synuclein filament have investigation of tau-promoted α-synuclein filaments using solid-state NMR and cryo-EM to state NMR studies indicate that the tau-promoted α-synuclein filaments have similar structural Resolution of the tau-promoted α-synuclein filament density map was not high enough for de novo Solid-state NMR of Tau-promoted α-synuclein filaments Representative TEM images of tau-promoted α-synuclein filaments showing the Cryo-EM structure of the tau-promoted α-synuclein filaments Overlaid structures of the tau-promoted α-synuclein filament (purple) and polymorph 2b (green). In this work, we solved cryo-EM structure of α-synuclein filaments derived by tau and increased helical twist of the tau-promoted full-length α-synuclein filaments may result from the Gath, J., Bousset, L., Habenstein, B., Melki, R., Bockmann, A., and Meier, B. ./cache/10_1101-2020_12_31_424989.pdf ./txt/10_1101-2020_12_31_424989.txt