id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
10_1101-2021_01_06_425536	Bignon, Emmanuelle	Recognition of a Tandem Lesion by DNA Glycosylases Explored Combining Molecular Dynamics and Machine Learning	2021	11	.pdf	application/pdf	8192	877	65	Recognition of a Tandem Lesion by DNA Glycosylases Explored Combining Molecular Dynamics and Machine Learning Keywords: MutM, DNA repair glycosylase, tandem lesion, molecular dynamics simulations important MutM/Fpg residues (K60, H74, Y242, K258, and R264) are known to stabilize the DNA helix by interacting with its structural behavior of Fpg and MutM in presence of tandem DNA lesions has been reported, despite the relevance that such show that the presence of the tandem lesion induces important structural deformations to the DNA that significantly perturb The interaction network as found in the MutM:DNA crystal containing a single 8-oxoG lesion is conserved stable along our Cartoon representation of MutM interacting with the DNA helix harboring a single 8-oxoG lesion (OG19, A) or dC7/Ap20 H-bond acceptor atoms lies at 2.6±1.1 Å and 3.0±1.8 Å, respectively, in the tandem-damaged MutM:DNA complex. Importance of the contribution of residues to the MutM:DNA complex bonding for the singly-damaged (blue) and	./cache/10_1101-2021_01_06_425536.pdf	./txt/10_1101-2021_01_06_425536.txt