id	sid	tid	token	lemma	pos
10_1101-2021_01_08_423993	1	1	Structural	structural	JJ
10_1101-2021_01_08_423993	1	2	and	and	CC
10_1101-2021_01_08_423993	1	3	mechanistic	mechanistic	JJ
10_1101-2021_01_08_423993	1	4	insights	insight	NNS
10_1101-2021_01_08_423993	1	5	into	into	IN
10_1101-2021_01_08_423993	1	6	the	the	DT
10_1101-2021_01_08_423993	1	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	1	8	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	1	9	and	and	CC
10_1101-2021_01_08_423993	1	10	strategies	strategy	NNS
10_1101-2021_01_08_423993	1	11	for	for	IN
10_1101-2021_01_08_423993	1	12	its	-PRON-	PRP$
10_1101-2021_01_08_423993	1	13	inhibition	inhibition	NN
10_1101-2021_01_08_423993	1	14	Structural	Structural	NNP
10_1101-2021_01_08_423993	1	15	and	and	CC
10_1101-2021_01_08_423993	1	16	mechanistic	mechanistic	JJ
10_1101-2021_01_08_423993	1	17	insights	insight	NNS
10_1101-2021_01_08_423993	1	18	into	into	IN
10_1101-2021_01_08_423993	1	19	the	the	DT
10_1101-2021_01_08_423993	1	20	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	1	21	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	1	22	and	and	CC
10_1101-2021_01_08_423993	1	23	strategies	strategy	NNS
10_1101-2021_01_08_423993	1	24	for	for	IN
10_1101-2021_01_08_423993	1	25	its	-PRON-	PRP$
10_1101-2021_01_08_423993	1	26	inhibition	inhibition	NN
10_1101-2021_01_08_423993	1	27	Yuliana	Yuliana	NNP
10_1101-2021_01_08_423993	1	28	Yosaatmadja1ⱡ	Yosaatmadja1ⱡ	NNP
10_1101-2021_01_08_423993	1	29	,	,	,
10_1101-2021_01_08_423993	1	30	Hannah	Hannah	NNP
10_1101-2021_01_08_423993	1	31	T	T	NNP
10_1101-2021_01_08_423993	1	32	Baddock2ⱡ	Baddock2ⱡ	NNP
10_1101-2021_01_08_423993	1	33	,	,	,
10_1101-2021_01_08_423993	1	34	Joseph	Joseph	NNP
10_1101-2021_01_08_423993	1	35	A	A	NNP
10_1101-2021_01_08_423993	1	36	Newman1	Newman1	NNP
10_1101-2021_01_08_423993	1	37	,	,	,
10_1101-2021_01_08_423993	1	38	Marcin	Marcin	NNP
10_1101-2021_01_08_423993	1	39	Bielinski3	Bielinski3	NNP
10_1101-2021_01_08_423993	1	40	,	,	,
10_1101-2021_01_08_423993	1	41	Angeline	Angeline	NNP
10_1101-2021_01_08_423993	1	42	E	E	NNP
10_1101-2021_01_08_423993	1	43	Gavard1	Gavard1	NNP
10_1101-2021_01_08_423993	1	44	,	,	,
10_1101-2021_01_08_423993	1	45	Shubhashish	Shubhashish	NNP
10_1101-2021_01_08_423993	1	46	M	M	NNP
10_1101-2021_01_08_423993	1	47	M	M	NNP
10_1101-2021_01_08_423993	1	48	Mukhopadhyay1	Mukhopadhyay1	NNP
10_1101-2021_01_08_423993	1	49	,	,	,
10_1101-2021_01_08_423993	1	50	Adam	Adam	NNP
10_1101-2021_01_08_423993	1	51	A	A	NNP
10_1101-2021_01_08_423993	1	52	Dannerfjord1	Dannerfjord1	NNP
10_1101-2021_01_08_423993	1	53	,	,	,
10_1101-2021_01_08_423993	1	54	Christopher	Christopher	NNP
10_1101-2021_01_08_423993	1	55	J	J	NNP
10_1101-2021_01_08_423993	1	56	Schofield3	Schofield3	NNP
10_1101-2021_01_08_423993	1	57	,	,	,
10_1101-2021_01_08_423993	1	58	Peter	Peter	NNP
10_1101-2021_01_08_423993	1	59	J	J	NNP
10_1101-2021_01_08_423993	1	60	McHugh2	McHugh2	NNP
10_1101-2021_01_08_423993	1	61	*	*	NFP
10_1101-2021_01_08_423993	1	62	,	,	,
10_1101-2021_01_08_423993	1	63	Opher	Opher	NNP
10_1101-2021_01_08_423993	1	64	Gileadi1	Gileadi1	NNP
10_1101-2021_01_08_423993	1	65	*	*	NFP
10_1101-2021_01_08_423993	1	66	.	.	.
10_1101-2021_01_08_423993	2	1	1Centre	1centre	CD
10_1101-2021_01_08_423993	2	2	for	for	IN
10_1101-2021_01_08_423993	2	3	Medicines	Medicines	NNP
10_1101-2021_01_08_423993	2	4	Discovery	Discovery	NNP
10_1101-2021_01_08_423993	2	5	,	,	,
10_1101-2021_01_08_423993	2	6	University	University	NNP
10_1101-2021_01_08_423993	2	7	of	of	IN
10_1101-2021_01_08_423993	2	8	Oxford	Oxford	NNP
10_1101-2021_01_08_423993	2	9	,	,	,
10_1101-2021_01_08_423993	2	10	ORCRB	ORCRB	NNP
10_1101-2021_01_08_423993	2	11	,	,	,
10_1101-2021_01_08_423993	2	12	Roosevelt	Roosevelt	NNP
10_1101-2021_01_08_423993	2	13	Drive	Drive	NNP
10_1101-2021_01_08_423993	2	14	,	,	,
10_1101-2021_01_08_423993	2	15	Oxford	Oxford	NNP
10_1101-2021_01_08_423993	2	16	,	,	,
10_1101-2021_01_08_423993	2	17	OX3	OX3	NNP
10_1101-2021_01_08_423993	2	18	7DQ	7DQ	NNP
10_1101-2021_01_08_423993	2	19	,	,	,
10_1101-2021_01_08_423993	2	20	United	United	NNP
10_1101-2021_01_08_423993	2	21	Kingdom	Kingdom	NNP
10_1101-2021_01_08_423993	2	22	;	;	:
10_1101-2021_01_08_423993	2	23	2Department	2department	CD
10_1101-2021_01_08_423993	2	24	of	of	IN
10_1101-2021_01_08_423993	2	25	Oncology	Oncology	NNP
10_1101-2021_01_08_423993	2	26	,	,	,
10_1101-2021_01_08_423993	2	27	MRC	MRC	NNP
10_1101-2021_01_08_423993	2	28	-	-	HYPH
10_1101-2021_01_08_423993	2	29	Weatherall	Weatherall	NNP
10_1101-2021_01_08_423993	2	30	Institute	Institute	NNP
10_1101-2021_01_08_423993	2	31	of	of	IN
10_1101-2021_01_08_423993	2	32	Molecular	Molecular	NNP
10_1101-2021_01_08_423993	2	33	Medicine	Medicine	NNP
10_1101-2021_01_08_423993	2	34	,	,	,
10_1101-2021_01_08_423993	2	35	University	University	NNP
10_1101-2021_01_08_423993	2	36	of	of	IN
10_1101-2021_01_08_423993	2	37	Oxford	Oxford	NNP
10_1101-2021_01_08_423993	2	38	,	,	,
10_1101-2021_01_08_423993	2	39	Oxford	Oxford	NNP
10_1101-2021_01_08_423993	2	40	OX3	OX3	NNP
10_1101-2021_01_08_423993	2	41	9DS	9ds	CD
10_1101-2021_01_08_423993	2	42	,	,	,
10_1101-2021_01_08_423993	2	43	United	United	NNP
10_1101-2021_01_08_423993	2	44	Kingdom	Kingdom	NNP
10_1101-2021_01_08_423993	2	45	;	;	:
10_1101-2021_01_08_423993	2	46	3Chemistry	3Chemistry	NNP
10_1101-2021_01_08_423993	2	47	Research	Research	NNP
10_1101-2021_01_08_423993	2	48	Laboratory	Laboratory	NNP
10_1101-2021_01_08_423993	2	49	,	,	,
10_1101-2021_01_08_423993	2	50	University	University	NNP
10_1101-2021_01_08_423993	2	51	of	of	IN
10_1101-2021_01_08_423993	2	52	Oxford	Oxford	NNP
10_1101-2021_01_08_423993	2	53	,	,	,
10_1101-2021_01_08_423993	2	54	Mansfield	Mansfield	NNP
10_1101-2021_01_08_423993	2	55	Road	Road	NNP
10_1101-2021_01_08_423993	2	56	,	,	,
10_1101-2021_01_08_423993	2	57	Oxford	Oxford	NNP
10_1101-2021_01_08_423993	2	58	,	,	,
10_1101-2021_01_08_423993	2	59	OX1	OX1	NNP
10_1101-2021_01_08_423993	2	60	3TA	3TA	NNP
10_1101-2021_01_08_423993	2	61	,	,	,
10_1101-2021_01_08_423993	2	62	United	United	NNP
10_1101-2021_01_08_423993	2	63	Kingdom	Kingdom	NNP
10_1101-2021_01_08_423993	2	64	.	.	.
10_1101-2021_01_08_423993	3	1	*	*	NFP
10_1101-2021_01_08_423993	3	2	To	to	IN
10_1101-2021_01_08_423993	3	3	whom	whom	WP
10_1101-2021_01_08_423993	3	4	correspondence	correspondence	NN
10_1101-2021_01_08_423993	3	5	should	should	MD
10_1101-2021_01_08_423993	3	6	be	be	VB
10_1101-2021_01_08_423993	3	7	addressed	address	VBN
10_1101-2021_01_08_423993	3	8	.	.	.
10_1101-2021_01_08_423993	4	1	email	email	NN
10_1101-2021_01_08_423993	4	2	:	:	:
10_1101-2021_01_08_423993	4	3	opher.gileadi@cmd.ox.ac.uk	opher.gileadi@cmd.ox.ac.uk	``
10_1101-2021_01_08_423993	4	4	Correspondence	Correspondence	NNP
10_1101-2021_01_08_423993	4	5	may	may	MD
10_1101-2021_01_08_423993	4	6	also	also	RB
10_1101-2021_01_08_423993	4	7	be	be	VB
10_1101-2021_01_08_423993	4	8	addressed	address	VBN
10_1101-2021_01_08_423993	4	9	to	to	IN
10_1101-2021_01_08_423993	4	10	peter.mchugh@imm.ox.ac.uk	peter.mchugh@imm.ox.ac.uk	ADD
10_1101-2021_01_08_423993	4	11	.	.	.
10_1101-2021_01_08_423993	5	1	ⱡ	ⱡ	LS
10_1101-2021_01_08_423993	5	2	These	these	DT
10_1101-2021_01_08_423993	5	3	authors	author	NNS
10_1101-2021_01_08_423993	5	4	contributed	contribute	VBD
10_1101-2021_01_08_423993	5	5	equally	equally	RB
10_1101-2021_01_08_423993	5	6	ABSTRACT	ABSTRACT	NNP
10_1101-2021_01_08_423993	5	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	5	8	(	(	-LRB-
10_1101-2021_01_08_423993	5	9	DCLRE1C	dclre1c	UH
10_1101-2021_01_08_423993	5	10	)	)	-RRB-
10_1101-2021_01_08_423993	5	11	is	be	VBZ
10_1101-2021_01_08_423993	5	12	an	an	DT
10_1101-2021_01_08_423993	5	13	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	5	14	that	that	WDT
10_1101-2021_01_08_423993	5	15	plays	play	VBZ
10_1101-2021_01_08_423993	5	16	a	a	DT
10_1101-2021_01_08_423993	5	17	key	key	JJ
10_1101-2021_01_08_423993	5	18	role	role	NN
10_1101-2021_01_08_423993	5	19	in	in	IN
10_1101-2021_01_08_423993	5	20	development	development	NN
10_1101-2021_01_08_423993	5	21	of	of	IN
10_1101-2021_01_08_423993	5	22	B-	b-	NN
10_1101-2021_01_08_423993	5	23	and	and	CC
10_1101-2021_01_08_423993	5	24	T-	T-	NNP
10_1101-2021_01_08_423993	5	25	lymphocytes	lymphocyte	NNS
10_1101-2021_01_08_423993	5	26	and	and	CC
10_1101-2021_01_08_423993	5	27	in	in	IN
10_1101-2021_01_08_423993	5	28	DNA	dna	NN
10_1101-2021_01_08_423993	5	29	double	double	JJ
10_1101-2021_01_08_423993	5	30	-	-	HYPH
10_1101-2021_01_08_423993	5	31	strand	strand	NN
10_1101-2021_01_08_423993	5	32	break	break	NN
10_1101-2021_01_08_423993	5	33	repair	repair	NN
10_1101-2021_01_08_423993	5	34	by	by	IN
10_1101-2021_01_08_423993	5	35	non	non	JJ
10_1101-2021_01_08_423993	5	36	-	-	JJ
10_1101-2021_01_08_423993	5	37	homologous	homologous	JJ
10_1101-2021_01_08_423993	5	38	end	end	NN
10_1101-2021_01_08_423993	5	39	-	-	HYPH
10_1101-2021_01_08_423993	5	40	joining	joining	NN
10_1101-2021_01_08_423993	5	41	(	(	-LRB-
10_1101-2021_01_08_423993	5	42	NHEJ	NHEJ	NNP
10_1101-2021_01_08_423993	5	43	)	)	-RRB-
10_1101-2021_01_08_423993	5	44	.	.	.
10_1101-2021_01_08_423993	6	1	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	6	2	is	be	VBZ
10_1101-2021_01_08_423993	6	3	phosphorylated	phosphorylate	VBN
10_1101-2021_01_08_423993	6	4	by	by	IN
10_1101-2021_01_08_423993	6	5	DNA	dna	NN
10_1101-2021_01_08_423993	6	6	-	-	HYPH
10_1101-2021_01_08_423993	6	7	PKcs	pkcs	NN
10_1101-2021_01_08_423993	6	8	and	and	CC
10_1101-2021_01_08_423993	6	9	acts	act	VBZ
10_1101-2021_01_08_423993	6	10	to	to	TO
10_1101-2021_01_08_423993	6	11	open	open	VB
10_1101-2021_01_08_423993	6	12	DNA	dna	NN
10_1101-2021_01_08_423993	6	13	hairpin	hairpin	NN
10_1101-2021_01_08_423993	6	14	intermediates	intermediate	NNS
10_1101-2021_01_08_423993	6	15	generated	generate	VBN
10_1101-2021_01_08_423993	6	16	during	during	IN
10_1101-2021_01_08_423993	6	17	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	6	18	and	and	CC
10_1101-2021_01_08_423993	6	19	class	class	NN
10_1101-2021_01_08_423993	6	20	-	-	HYPH
10_1101-2021_01_08_423993	6	21	switch	switch	NN
10_1101-2021_01_08_423993	6	22	recombination	recombination	NN
10_1101-2021_01_08_423993	6	23	.	.	.
10_1101-2021_01_08_423993	7	1	Consistently	consistently	RB
10_1101-2021_01_08_423993	7	2	,	,	,
10_1101-2021_01_08_423993	7	3	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	7	4	deficiency	deficiency	NN
10_1101-2021_01_08_423993	7	5	leads	lead	VBZ
10_1101-2021_01_08_423993	7	6	to	to	TO
10_1101-2021_01_08_423993	7	7	radiosensitive	radiosensitive	VB
10_1101-2021_01_08_423993	7	8	congenital	congenital	JJ
10_1101-2021_01_08_423993	7	9	severe	severe	JJ
10_1101-2021_01_08_423993	7	10	immune	immune	JJ
10_1101-2021_01_08_423993	7	11	deficiency	deficiency	NN
10_1101-2021_01_08_423993	7	12	(	(	-LRB-
10_1101-2021_01_08_423993	7	13	RS	RS	NNP
10_1101-2021_01_08_423993	7	14	-	-	HYPH
10_1101-2021_01_08_423993	7	15	SCID	SCID	NNP
10_1101-2021_01_08_423993	7	16	)	)	-RRB-
10_1101-2021_01_08_423993	7	17	.	.	.
10_1101-2021_01_08_423993	8	1	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	8	2	belongs	belong	VBZ
10_1101-2021_01_08_423993	8	3	to	to	IN
10_1101-2021_01_08_423993	8	4	a	a	DT
10_1101-2021_01_08_423993	8	5	structural	structural	JJ
10_1101-2021_01_08_423993	8	6	superfamily	superfamily	NN
10_1101-2021_01_08_423993	8	7	of	of	IN
10_1101-2021_01_08_423993	8	8	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	8	9	that	that	WDT
10_1101-2021_01_08_423993	8	10	contain	contain	VBP
10_1101-2021_01_08_423993	8	11	conserved	conserve	VBN
10_1101-2021_01_08_423993	8	12	metallo	metallo	NN
10_1101-2021_01_08_423993	8	13	-	-	HYPH
10_1101-2021_01_08_423993	8	14	β	β	NN
10_1101-2021_01_08_423993	8	15	-	-	HYPH
10_1101-2021_01_08_423993	8	16	lactamase	lactamase	NN
10_1101-2021_01_08_423993	8	17	(	(	-LRB-
10_1101-2021_01_08_423993	8	18	MBL	MBL	NNP
10_1101-2021_01_08_423993	8	19	)	)	-RRB-
10_1101-2021_01_08_423993	8	20	and	and	CC
10_1101-2021_01_08_423993	8	21	β	β	NNP
10_1101-2021_01_08_423993	8	22	-	-	HYPH
10_1101-2021_01_08_423993	8	23	CASP	CASP	NNP
10_1101-2021_01_08_423993	8	24	(	(	-LRB-
10_1101-2021_01_08_423993	8	25	CPSF	CPSF	NNP
10_1101-2021_01_08_423993	8	26	-	-	HYPH
10_1101-2021_01_08_423993	8	27	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	8	28	-	-	HYPH
10_1101-2021_01_08_423993	8	29	SNM1-Pso2	SNM1-Pso2	NNP
10_1101-2021_01_08_423993	8	30	)	)	-RRB-
10_1101-2021_01_08_423993	8	31	domains	domain	NNS
10_1101-2021_01_08_423993	8	32	.	.	.
10_1101-2021_01_08_423993	9	1	Here	here	RB
10_1101-2021_01_08_423993	9	2	,	,	,
10_1101-2021_01_08_423993	9	3	we	-PRON-	PRP
10_1101-2021_01_08_423993	9	4	present	present	VBP
10_1101-2021_01_08_423993	9	5	crystal	crystal	NN
10_1101-2021_01_08_423993	9	6	structures	structure	NNS
10_1101-2021_01_08_423993	9	7	of	of	IN
10_1101-2021_01_08_423993	9	8	the	the	DT
10_1101-2021_01_08_423993	9	9	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	9	10	domain	domain	NN
10_1101-2021_01_08_423993	9	11	of	of	IN
10_1101-2021_01_08_423993	9	12	wild	wild	JJ
10_1101-2021_01_08_423993	9	13	type	type	NN
10_1101-2021_01_08_423993	9	14	and	and	CC
10_1101-2021_01_08_423993	9	15	variant	variant	JJ
10_1101-2021_01_08_423993	9	16	forms	form	NNS
10_1101-2021_01_08_423993	9	17	of	of	IN
10_1101-2021_01_08_423993	9	18	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	9	19	that	that	WDT
10_1101-2021_01_08_423993	9	20	cause	cause	VBP
10_1101-2021_01_08_423993	9	21	RS	RS	NNP
10_1101-2021_01_08_423993	9	22	-	-	HYPH
10_1101-2021_01_08_423993	9	23	SCID	SCID	NNP
10_1101-2021_01_08_423993	9	24	Omenn	Omenn	NNP
10_1101-2021_01_08_423993	9	25	syndrome	syndrome	NN
10_1101-2021_01_08_423993	9	26	.	.	.
10_1101-2021_01_08_423993	10	1	The	the	DT
10_1101-2021_01_08_423993	10	2	truncated	truncate	VBN
10_1101-2021_01_08_423993	10	3	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	10	4	domain	domain	NN
10_1101-2021_01_08_423993	10	5	of	of	IN
10_1101-2021_01_08_423993	10	6	the	the	DT
10_1101-2021_01_08_423993	10	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	10	8	is	be	VBZ
10_1101-2021_01_08_423993	10	9	a	a	DT
10_1101-2021_01_08_423993	10	10	constitutively	constitutively	RB
10_1101-2021_01_08_423993	10	11	active	active	JJ
10_1101-2021_01_08_423993	10	12	enzyme	enzyme	NNS
10_1101-2021_01_08_423993	10	13	that	that	WDT
10_1101-2021_01_08_423993	10	14	with	with	IN
10_1101-2021_01_08_423993	10	15	similar	similar	JJ
10_1101-2021_01_08_423993	10	16	activity	activity	NN
10_1101-2021_01_08_423993	10	17	to	to	IN
10_1101-2021_01_08_423993	10	18	a	a	DT
10_1101-2021_01_08_423993	10	19	phosphorylated	phosphorylate	VBN
10_1101-2021_01_08_423993	10	20	full	full	JJ
10_1101-2021_01_08_423993	10	21	-	-	HYPH
10_1101-2021_01_08_423993	10	22	length	length	NN
10_1101-2021_01_08_423993	10	23	protein	protein	NN
10_1101-2021_01_08_423993	10	24	.	.	.
10_1101-2021_01_08_423993	11	1	Our	-PRON-	PRP$
10_1101-2021_01_08_423993	11	2	structures	structure	NNS
10_1101-2021_01_08_423993	11	3	help	help	VBP
10_1101-2021_01_08_423993	11	4	explain	explain	VB
10_1101-2021_01_08_423993	11	5	the	the	DT
10_1101-2021_01_08_423993	11	6	basis	basis	NN
10_1101-2021_01_08_423993	11	7	of	of	IN
10_1101-2021_01_08_423993	11	8	the	the	DT
10_1101-2021_01_08_423993	11	9	predominantly	predominantly	RB
10_1101-2021_01_08_423993	11	10	endonucleolytic	endonucleolytic	JJ
10_1101-2021_01_08_423993	11	11	activity	activity	NN
10_1101-2021_01_08_423993	11	12	of	of	IN
10_1101-2021_01_08_423993	11	13	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	11	14	,	,	,
10_1101-2021_01_08_423993	11	15	which	which	WDT
10_1101-2021_01_08_423993	11	16	contrast	contrast	NN
10_1101-2021_01_08_423993	11	17	with	with	IN
10_1101-2021_01_08_423993	11	18	the	the	DT
10_1101-2021_01_08_423993	11	19	predominantly	predominantly	RB
10_1101-2021_01_08_423993	11	20	exonuclease	exonuclease	NN
10_1101-2021_01_08_423993	11	21	activity	activity	NN
10_1101-2021_01_08_423993	11	22	of	of	IN
10_1101-2021_01_08_423993	11	23	the	the	DT
10_1101-2021_01_08_423993	11	24	closely	closely	RB
10_1101-2021_01_08_423993	11	25	related	related	JJ
10_1101-2021_01_08_423993	11	26	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	11	27	and	and	CC
10_1101-2021_01_08_423993	11	28	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	11	29	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	11	30	.	.	.
10_1101-2021_01_08_423993	12	1	The	the	DT
10_1101-2021_01_08_423993	12	2	structures	structure	NNS
10_1101-2021_01_08_423993	12	3	also	also	RB
10_1101-2021_01_08_423993	12	4	reveal	reveal	VBP
10_1101-2021_01_08_423993	12	5	a	a	DT
10_1101-2021_01_08_423993	12	6	second	second	JJ
10_1101-2021_01_08_423993	12	7	metal	metal	NN
10_1101-2021_01_08_423993	12	8	binding	bind	VBG
10_1101-2021_01_08_423993	12	9	site	site	NN
10_1101-2021_01_08_423993	12	10	in	in	IN
10_1101-2021_01_08_423993	12	11	its	-PRON-	PRP$
10_1101-2021_01_08_423993	12	12	β	β	NNP
10_1101-2021_01_08_423993	12	13	-	-	HYPH
10_1101-2021_01_08_423993	12	14	CASP	CASP	NNP
10_1101-2021_01_08_423993	12	15	domain	domain	NN
10_1101-2021_01_08_423993	12	16	that	that	WDT
10_1101-2021_01_08_423993	12	17	is	be	VBZ
10_1101-2021_01_08_423993	12	18	unique	unique	JJ
10_1101-2021_01_08_423993	12	19	to	to	IN
10_1101-2021_01_08_423993	12	20	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	12	21	.	.	.
10_1101-2021_01_08_423993	13	1	By	by	IN
10_1101-2021_01_08_423993	13	2	combining	combine	VBG
10_1101-2021_01_08_423993	13	3	our	-PRON-	PRP$
10_1101-2021_01_08_423993	13	4	structural	structural	JJ
10_1101-2021_01_08_423993	13	5	data	datum	NNS
10_1101-2021_01_08_423993	13	6	that	that	WDT
10_1101-2021_01_08_423993	13	7	from	from	IN
10_1101-2021_01_08_423993	13	8	a	a	DT
10_1101-2021_01_08_423993	13	9	recently	recently	RB
10_1101-2021_01_08_423993	13	10	reported	report	VBN
10_1101-2021_01_08_423993	13	11	structure	structure	NN
10_1101-2021_01_08_423993	13	12	we	-PRON-	PRP
10_1101-2021_01_08_423993	13	13	were	be	VBD
10_1101-2021_01_08_423993	13	14	able	able	JJ
10_1101-2021_01_08_423993	13	15	model	model	NN
10_1101-2021_01_08_423993	13	16	the	the	DT
10_1101-2021_01_08_423993	13	17	interaction	interaction	NN
10_1101-2021_01_08_423993	13	18	of	of	IN
10_1101-2021_01_08_423993	13	19	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	13	20	with	with	IN
10_1101-2021_01_08_423993	13	21	DNA	DNA	NNP
10_1101-2021_01_08_423993	13	22	substrates	substrate	NNS
10_1101-2021_01_08_423993	13	23	.	.	.
10_1101-2021_01_08_423993	14	1	Moreover	moreover	RB
10_1101-2021_01_08_423993	14	2	,	,	,
10_1101-2021_01_08_423993	14	3	co	co	JJ
10_1101-2021_01_08_423993	14	4	-	-	NN
10_1101-2021_01_08_423993	14	5	crystal	crystal	JJ
10_1101-2021_01_08_423993	14	6	structures	structure	NNS
10_1101-2021_01_08_423993	14	7	with	with	IN
10_1101-2021_01_08_423993	14	8	inhibitors	inhibitor	NNS
10_1101-2021_01_08_423993	14	9	indicate	indicate	VBP
10_1101-2021_01_08_423993	14	10	the	the	DT
10_1101-2021_01_08_423993	14	11	potential	potential	NN
10_1101-2021_01_08_423993	14	12	for	for	IN
10_1101-2021_01_08_423993	14	13	structure	structure	NN
10_1101-2021_01_08_423993	14	14	-	-	HYPH
10_1101-2021_01_08_423993	14	15	guided	guide	VBN
10_1101-2021_01_08_423993	14	16	development	development	NN
10_1101-2021_01_08_423993	14	17	of	of	IN
10_1101-2021_01_08_423993	14	18	inhibitors	inhibitor	NNS
10_1101-2021_01_08_423993	14	19	.	.	.
10_1101-2021_01_08_423993	15	1	INTRODUCTION	INTRODUCTION	NNP
10_1101-2021_01_08_423993	15	2	Nucleases	Nucleases	NNPS
10_1101-2021_01_08_423993	15	3	hydrolyse	hydrolyse	VBP
10_1101-2021_01_08_423993	15	4	the	the	DT
10_1101-2021_01_08_423993	15	5	phosphodiester	phosphodiester	NN
10_1101-2021_01_08_423993	15	6	bonds	bond	NNS
10_1101-2021_01_08_423993	15	7	of	of	IN
10_1101-2021_01_08_423993	15	8	nucleic	nucleic	JJ
10_1101-2021_01_08_423993	15	9	acids	acid	NNS
10_1101-2021_01_08_423993	15	10	and	and	CC
10_1101-2021_01_08_423993	15	11	are	be	VBP
10_1101-2021_01_08_423993	15	12	grouped	group	VBN
10_1101-2021_01_08_423993	15	13	into	into	IN
10_1101-2021_01_08_423993	15	14	two	two	CD
10_1101-2021_01_08_423993	15	15	broad	broad	JJ
10_1101-2021_01_08_423993	15	16	classes	class	NNS
10_1101-2021_01_08_423993	15	17	:	:	:
10_1101-2021_01_08_423993	15	18	exonucleases	exonuclease	NNS
10_1101-2021_01_08_423993	15	19	and	and	CC
10_1101-2021_01_08_423993	15	20	endonucleases	endonuclease	NNS
10_1101-2021_01_08_423993	15	21	.	.	.
10_1101-2021_01_08_423993	16	1	Exonucleases	exonuclease	NNS
10_1101-2021_01_08_423993	16	2	are	be	VBP
10_1101-2021_01_08_423993	16	3	often	often	RB
10_1101-2021_01_08_423993	16	4	non	non	JJ
10_1101-2021_01_08_423993	16	5	sequence-	sequence-	JJ
10_1101-2021_01_08_423993	16	6	specific	specific	JJ
10_1101-2021_01_08_423993	16	7	,	,	,
10_1101-2021_01_08_423993	16	8	while	while	IN
10_1101-2021_01_08_423993	16	9	endonucleases	endonuclease	NNS
10_1101-2021_01_08_423993	16	10	can	can	MD
10_1101-2021_01_08_423993	16	11	be	be	VB
10_1101-2021_01_08_423993	16	12	further	further	RB
10_1101-2021_01_08_423993	16	13	grouped	group	VBN
10_1101-2021_01_08_423993	16	14	into	into	IN
10_1101-2021_01_08_423993	16	15	sequence	sequence	NN
10_1101-2021_01_08_423993	16	16	-	-	HYPH
10_1101-2021_01_08_423993	16	17	specific	specific	NN
10_1101-2021_01_08_423993	16	18	.CC	.CC	,
10_1101-2021_01_08_423993	16	19	-	-	:
10_1101-2021_01_08_423993	16	20	BY	by	IN
10_1101-2021_01_08_423993	16	21	4.0	4.0	CD
10_1101-2021_01_08_423993	16	22	International	international	JJ
10_1101-2021_01_08_423993	16	23	licensemade	licensemade	NN
10_1101-2021_01_08_423993	16	24	available	available	JJ
10_1101-2021_01_08_423993	16	25	under	under	IN
10_1101-2021_01_08_423993	16	26	a	a	DT
10_1101-2021_01_08_423993	16	27	(	(	-LRB-
10_1101-2021_01_08_423993	16	28	which	which	WDT
10_1101-2021_01_08_423993	16	29	was	be	VBD
10_1101-2021_01_08_423993	16	30	not	not	RB
10_1101-2021_01_08_423993	16	31	certified	certify	VBN
10_1101-2021_01_08_423993	16	32	by	by	IN
10_1101-2021_01_08_423993	16	33	peer	peer	NN
10_1101-2021_01_08_423993	16	34	review	review	NN
10_1101-2021_01_08_423993	16	35	)	)	-RRB-
10_1101-2021_01_08_423993	16	36	is	be	VBZ
10_1101-2021_01_08_423993	16	37	the	the	DT
10_1101-2021_01_08_423993	16	38	author	author	NN
10_1101-2021_01_08_423993	16	39	/	/	SYM
10_1101-2021_01_08_423993	16	40	funder	funder	NN
10_1101-2021_01_08_423993	16	41	,	,	,
10_1101-2021_01_08_423993	16	42	who	who	WP
10_1101-2021_01_08_423993	16	43	has	have	VBZ
10_1101-2021_01_08_423993	16	44	granted	grant	VBN
10_1101-2021_01_08_423993	16	45	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	16	46	a	a	DT
10_1101-2021_01_08_423993	16	47	license	license	NN
10_1101-2021_01_08_423993	16	48	to	to	TO
10_1101-2021_01_08_423993	16	49	display	display	VB
10_1101-2021_01_08_423993	16	50	the	the	DT
10_1101-2021_01_08_423993	16	51	preprint	preprint	NN
10_1101-2021_01_08_423993	16	52	in	in	IN
10_1101-2021_01_08_423993	16	53	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	16	54	.	.	.
10_1101-2021_01_08_423993	17	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	17	2	is	be	VBZ
10_1101-2021_01_08_423993	17	3	The	the	DT
10_1101-2021_01_08_423993	17	4	copyright	copyright	NN
10_1101-2021_01_08_423993	17	5	holder	holder	NN
10_1101-2021_01_08_423993	17	6	for	for	IN
10_1101-2021_01_08_423993	17	7	this	this	DT
10_1101-2021_01_08_423993	17	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	17	9	version	version	NN
10_1101-2021_01_08_423993	17	10	posted	post	VBD
10_1101-2021_01_08_423993	17	11	January	January	NNP
10_1101-2021_01_08_423993	17	12	8	8	CD
10_1101-2021_01_08_423993	17	13	,	,	,
10_1101-2021_01_08_423993	17	14	2021	2021	CD
10_1101-2021_01_08_423993	17	15	.	.	.
10_1101-2021_01_08_423993	17	16	;	;	:
10_1101-2021_01_08_423993	17	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	17	18	:	:	:
10_1101-2021_01_08_423993	17	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	17	20	preprint	preprint	NN
10_1101-2021_01_08_423993	17	21	mailto:peter.mchugh@imm.ox.ac.uk	mailto:peter.mchugh@imm.ox.ac.uk	NNP
10_1101-2021_01_08_423993	17	22	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	NNP
10_1101-2021_01_08_423993	17	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	17	24	endonucleases	endonuclease	NNS
10_1101-2021_01_08_423993	17	25	,	,	,
10_1101-2021_01_08_423993	17	26	such	such	JJ
10_1101-2021_01_08_423993	17	27	as	as	IN
10_1101-2021_01_08_423993	17	28	restriction	restriction	NN
10_1101-2021_01_08_423993	17	29	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	17	30	,	,	,
10_1101-2021_01_08_423993	17	31	and	and	CC
10_1101-2021_01_08_423993	17	32	structure	structure	NN
10_1101-2021_01_08_423993	17	33	-	-	HYPH
10_1101-2021_01_08_423993	17	34	selective	selective	JJ
10_1101-2021_01_08_423993	17	35	endonucleases	endonuclease	NNS
10_1101-2021_01_08_423993	17	36	[	[	-LRB-
10_1101-2021_01_08_423993	17	37	1	1	CD
10_1101-2021_01_08_423993	17	38	]	]	-RRB-
10_1101-2021_01_08_423993	17	39	.	.	.
10_1101-2021_01_08_423993	18	1	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	18	2	(	(	-LRB-
10_1101-2021_01_08_423993	18	3	also	also	RB
10_1101-2021_01_08_423993	18	4	known	know	VBN
10_1101-2021_01_08_423993	18	5	as	as	IN
10_1101-2021_01_08_423993	18	6	SNM1C	snm1c	CD
10_1101-2021_01_08_423993	18	7	or	or	CC
10_1101-2021_01_08_423993	18	8	DCLRE1C	dclre1c	UH
10_1101-2021_01_08_423993	18	9	)	)	-RRB-
10_1101-2021_01_08_423993	18	10	,	,	,
10_1101-2021_01_08_423993	18	11	along	along	IN
10_1101-2021_01_08_423993	18	12	with	with	IN
10_1101-2021_01_08_423993	18	13	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	18	14	(	(	-LRB-
10_1101-2021_01_08_423993	18	15	DCLRE1A	DCLRE1A	NNP
10_1101-2021_01_08_423993	18	16	)	)	-RRB-
10_1101-2021_01_08_423993	18	17	and	and	CC
10_1101-2021_01_08_423993	18	18	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	18	19	(	(	-LRB-
10_1101-2021_01_08_423993	18	20	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	18	21	or	or	CC
10_1101-2021_01_08_423993	18	22	DCLRE1B	DCLRE1B	NNP
10_1101-2021_01_08_423993	18	23	)	)	-RRB-
10_1101-2021_01_08_423993	18	24	,	,	,
10_1101-2021_01_08_423993	18	25	are	be	VBP
10_1101-2021_01_08_423993	18	26	human	human	JJ
10_1101-2021_01_08_423993	18	27	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	18	28	that	that	WDT
10_1101-2021_01_08_423993	18	29	fall	fall	VBP
10_1101-2021_01_08_423993	18	30	into	into	IN
10_1101-2021_01_08_423993	18	31	the	the	DT
10_1101-2021_01_08_423993	18	32	extended	extended	JJ
10_1101-2021_01_08_423993	18	33	structural	structural	JJ
10_1101-2021_01_08_423993	18	34	family	family	NN
10_1101-2021_01_08_423993	18	35	of	of	IN
10_1101-2021_01_08_423993	18	36	metallo	metallo	NNP
10_1101-2021_01_08_423993	18	37	-	-	HYPH
10_1101-2021_01_08_423993	18	38	β	β	NN
10_1101-2021_01_08_423993	18	39	-	-	HYPH
10_1101-2021_01_08_423993	18	40	lactamase	lactamase	NN
10_1101-2021_01_08_423993	18	41	(	(	-LRB-
10_1101-2021_01_08_423993	18	42	MBL	MBL	NNP
10_1101-2021_01_08_423993	18	43	)	)	-RRB-
10_1101-2021_01_08_423993	18	44	fold	fold	VB
10_1101-2021_01_08_423993	18	45	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	18	46	[	[	-LRB-
10_1101-2021_01_08_423993	18	47	2,3	2,3	CD
10_1101-2021_01_08_423993	18	48	]	]	-RRB-
10_1101-2021_01_08_423993	18	49	.	.	.
10_1101-2021_01_08_423993	19	1	The	the	DT
10_1101-2021_01_08_423993	19	2	N	n	CD
10_1101-2021_01_08_423993	19	3	-	-	HYPH
10_1101-2021_01_08_423993	19	4	terminal	terminal	NN
10_1101-2021_01_08_423993	19	5	region	region	NN
10_1101-2021_01_08_423993	19	6	of	of	IN
10_1101-2021_01_08_423993	19	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	19	8	is	be	VBZ
10_1101-2021_01_08_423993	19	9	predicted	predict	VBN
10_1101-2021_01_08_423993	19	10	to	to	TO
10_1101-2021_01_08_423993	19	11	have	have	VB
10_1101-2021_01_08_423993	19	12	a	a	DT
10_1101-2021_01_08_423993	19	13	core	core	NN
10_1101-2021_01_08_423993	19	14	MBL	MBL	NNP
10_1101-2021_01_08_423993	19	15	fold	fold	VB
10_1101-2021_01_08_423993	19	16	(	(	-LRB-
10_1101-2021_01_08_423993	19	17	aa	aa	NNP
10_1101-2021_01_08_423993	19	18	1–155	1–155	NNP
10_1101-2021_01_08_423993	19	19	,	,	,
10_1101-2021_01_08_423993	19	20	385–361	385–361	CD
10_1101-2021_01_08_423993	19	21	)	)	-RRB-
10_1101-2021_01_08_423993	19	22	with	with	IN
10_1101-2021_01_08_423993	19	23	an	an	DT
10_1101-2021_01_08_423993	19	24	inserted	insert	VBN
10_1101-2021_01_08_423993	19	25	β	β	NNP
10_1101-2021_01_08_423993	19	26	-	-	HYPH
10_1101-2021_01_08_423993	19	27	CASP	CASP	NNP
10_1101-2021_01_08_423993	19	28	(	(	-LRB-
10_1101-2021_01_08_423993	19	29	CPSF73	CPSF73	NNP
10_1101-2021_01_08_423993	19	30	,	,	,
10_1101-2021_01_08_423993	19	31	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	19	32	,	,	,
10_1101-2021_01_08_423993	19	33	SNM1	SNM1	NNP
10_1101-2021_01_08_423993	19	34	and	and	CC
10_1101-2021_01_08_423993	19	35	PSO2	PSO2	NNPS
10_1101-2021_01_08_423993	19	36	)	)	-RRB-
10_1101-2021_01_08_423993	19	37	domain	domain	NN
10_1101-2021_01_08_423993	19	38	(	(	-LRB-
10_1101-2021_01_08_423993	19	39	aa	aa	NNP
10_1101-2021_01_08_423993	19	40	156–384	156–384	CD
10_1101-2021_01_08_423993	19	41	)	)	-RRB-
10_1101-2021_01_08_423993	19	42	.	.	.
10_1101-2021_01_08_423993	20	1	β	β	LS
10_1101-2021_01_08_423993	20	2	-	-	:
10_1101-2021_01_08_423993	20	3	CASP	CASP	NNP
10_1101-2021_01_08_423993	20	4	domains	domain	NNS
10_1101-2021_01_08_423993	20	5	are	be	VBP
10_1101-2021_01_08_423993	20	6	present	present	JJ
10_1101-2021_01_08_423993	20	7	within	within	IN
10_1101-2021_01_08_423993	20	8	the	the	DT
10_1101-2021_01_08_423993	20	9	larger	large	JJR
10_1101-2021_01_08_423993	20	10	family	family	NN
10_1101-2021_01_08_423993	20	11	of	of	IN
10_1101-2021_01_08_423993	20	12	eukaryotic	eukaryotic	JJ
10_1101-2021_01_08_423993	20	13	nucleic	nucleic	NNS
10_1101-2021_01_08_423993	20	14	acid	acid	NN
10_1101-2021_01_08_423993	20	15	processing	process	VBG
10_1101-2021_01_08_423993	20	16	MBLs	mbl	NNS
10_1101-2021_01_08_423993	20	17	and	and	CC
10_1101-2021_01_08_423993	20	18	confer	confer	VB
10_1101-2021_01_08_423993	20	19	both	both	DT
10_1101-2021_01_08_423993	20	20	DNA	DNA	NNP
10_1101-2021_01_08_423993	20	21	/	/	SYM
10_1101-2021_01_08_423993	20	22	RNA	RNA	NNP
10_1101-2021_01_08_423993	20	23	binding	binding	NN
10_1101-2021_01_08_423993	20	24	and	and	CC
10_1101-2021_01_08_423993	20	25	nuclease	nuclease	NN
10_1101-2021_01_08_423993	20	26	activity	activity	NN
10_1101-2021_01_08_423993	20	27	[	[	-LRB-
10_1101-2021_01_08_423993	20	28	2	2	CD
10_1101-2021_01_08_423993	20	29	]	]	-RRB-
10_1101-2021_01_08_423993	20	30	.	.	.
10_1101-2021_01_08_423993	21	1	The	the	DT
10_1101-2021_01_08_423993	21	2	C	C	NNP
10_1101-2021_01_08_423993	21	3	-	-	HYPH
10_1101-2021_01_08_423993	21	4	terminal	terminal	NN
10_1101-2021_01_08_423993	21	5	region	region	NN
10_1101-2021_01_08_423993	21	6	of	of	IN
10_1101-2021_01_08_423993	21	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	21	8	mediates	mediate	VBZ
10_1101-2021_01_08_423993	21	9	protein	protein	NN
10_1101-2021_01_08_423993	21	10	-	-	HYPH
10_1101-2021_01_08_423993	21	11	protein	protein	NN
10_1101-2021_01_08_423993	21	12	interactions	interaction	NNS
10_1101-2021_01_08_423993	21	13	,	,	,
10_1101-2021_01_08_423993	21	14	contains	contain	VBZ
10_1101-2021_01_08_423993	21	15	post	post	JJ
10_1101-2021_01_08_423993	21	16	translational	translational	JJ
10_1101-2021_01_08_423993	21	17	modification	modification	NN
10_1101-2021_01_08_423993	21	18	(	(	-LRB-
10_1101-2021_01_08_423993	21	19	PTM	PTM	NNP
10_1101-2021_01_08_423993	21	20	)	)	-RRB-
10_1101-2021_01_08_423993	21	21	sites	site	NNS
10_1101-2021_01_08_423993	21	22	,	,	,
10_1101-2021_01_08_423993	21	23	directs	direct	VBZ
10_1101-2021_01_08_423993	21	24	subcellular	subcellular	JJ
10_1101-2021_01_08_423993	21	25	localisation	localisation	NN
10_1101-2021_01_08_423993	21	26	,	,	,
10_1101-2021_01_08_423993	21	27	and	and	CC
10_1101-2021_01_08_423993	21	28	may	may	MD
10_1101-2021_01_08_423993	21	29	modulate	modulate	VB
10_1101-2021_01_08_423993	21	30	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	21	31	activity	activity	NN
10_1101-2021_01_08_423993	21	32	[	[	-LRB-
10_1101-2021_01_08_423993	21	33	4–7	4–7	CD
10_1101-2021_01_08_423993	21	34	]	]	-RRB-
10_1101-2021_01_08_423993	21	35	.	.	.
10_1101-2021_01_08_423993	22	1	Although	although	IN
10_1101-2021_01_08_423993	22	2	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	22	3	,	,	,
10_1101-2021_01_08_423993	22	4	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	22	5	,	,	,
10_1101-2021_01_08_423993	22	6	and	and	CC
10_1101-2021_01_08_423993	22	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	22	8	are	be	VBP
10_1101-2021_01_08_423993	22	9	predicted	predict	VBN
10_1101-2021_01_08_423993	22	10	to	to	TO
10_1101-2021_01_08_423993	22	11	have	have	VB
10_1101-2021_01_08_423993	22	12	similar	similar	JJ
10_1101-2021_01_08_423993	22	13	core	core	NN
10_1101-2021_01_08_423993	22	14	structures	structure	NNS
10_1101-2021_01_08_423993	22	15	for	for	IN
10_1101-2021_01_08_423993	22	16	their	-PRON-	PRP$
10_1101-2021_01_08_423993	22	17	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	22	18	domains	domain	NNS
10_1101-2021_01_08_423993	22	19	,	,	,
10_1101-2021_01_08_423993	22	20	each	each	DT
10_1101-2021_01_08_423993	22	21	have	have	VBP
10_1101-2021_01_08_423993	22	22	distinct	distinct	JJ
10_1101-2021_01_08_423993	22	23	cellular	cellular	JJ
10_1101-2021_01_08_423993	22	24	functions	function	NNS
10_1101-2021_01_08_423993	22	25	and	and	CC
10_1101-2021_01_08_423993	22	26	substrate	substrate	NN
10_1101-2021_01_08_423993	22	27	specificities	specificity	NNS
10_1101-2021_01_08_423993	22	28	.	.	.
10_1101-2021_01_08_423993	23	1	While	while	IN
10_1101-2021_01_08_423993	23	2	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	23	3	and	and	CC
10_1101-2021_01_08_423993	23	4	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	23	5	/	/	SYM
10_1101-2021_01_08_423993	23	6	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	23	7	are	be	VBP
10_1101-2021_01_08_423993	23	8	exclusively	exclusively	RB
10_1101-2021_01_08_423993	23	9	5	5	CD
10_1101-2021_01_08_423993	23	10	'	'	''
10_1101-2021_01_08_423993	23	11	to	to	IN
10_1101-2021_01_08_423993	23	12	3	3	CD
10_1101-2021_01_08_423993	23	13	'	'	POS
10_1101-2021_01_08_423993	23	14	exonucleases	exonuclease	NNS
10_1101-2021_01_08_423993	23	15	,	,	,
10_1101-2021_01_08_423993	23	16	the	the	DT
10_1101-2021_01_08_423993	23	17	predominant	predominant	JJ
10_1101-2021_01_08_423993	23	18	activity	activity	NN
10_1101-2021_01_08_423993	23	19	of	of	IN
10_1101-2021_01_08_423993	23	20	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	23	21	is	be	VBZ
10_1101-2021_01_08_423993	23	22	endonucleolytic	endonucleolytic	JJ
10_1101-2021_01_08_423993	23	23	[	[	-LRB-
10_1101-2021_01_08_423993	23	24	5,7	5,7	CD
10_1101-2021_01_08_423993	23	25	]	]	-RRB-
10_1101-2021_01_08_423993	23	26	,	,	,
10_1101-2021_01_08_423993	23	27	although	although	IN
10_1101-2021_01_08_423993	23	28	a	a	DT
10_1101-2021_01_08_423993	23	29	minor	minor	JJ
10_1101-2021_01_08_423993	23	30	5	5	CD
10_1101-2021_01_08_423993	23	31	'	'	''
10_1101-2021_01_08_423993	23	32	to	to	IN
10_1101-2021_01_08_423993	23	33	3	3	CD
10_1101-2021_01_08_423993	23	34	'	'	POS
10_1101-2021_01_08_423993	23	35	exonuclease	exonuclease	NN
10_1101-2021_01_08_423993	23	36	activity	activity	NN
10_1101-2021_01_08_423993	23	37	has	have	VBZ
10_1101-2021_01_08_423993	23	38	been	be	VBN
10_1101-2021_01_08_423993	23	39	reported	report	VBN
10_1101-2021_01_08_423993	23	40	[	[	-LRB-
10_1101-2021_01_08_423993	23	41	8	8	CD
10_1101-2021_01_08_423993	23	42	]	]	-RRB-
10_1101-2021_01_08_423993	23	43	.	.	.
10_1101-2021_01_08_423993	24	1	Human	human	JJ
10_1101-2021_01_08_423993	24	2	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	24	3	localises	localise	NNS
10_1101-2021_01_08_423993	24	4	to	to	IN
10_1101-2021_01_08_423993	24	5	sites	site	NNS
10_1101-2021_01_08_423993	24	6	of	of	IN
10_1101-2021_01_08_423993	24	7	DNA	dna	NN
10_1101-2021_01_08_423993	24	8	damage	damage	NN
10_1101-2021_01_08_423993	24	9	,	,	,
10_1101-2021_01_08_423993	24	10	can	can	MD
10_1101-2021_01_08_423993	24	11	digest	digest	VB
10_1101-2021_01_08_423993	24	12	past	past	IN
10_1101-2021_01_08_423993	24	13	DNA	dna	NN
10_1101-2021_01_08_423993	24	14	damage	damage	NN
10_1101-2021_01_08_423993	24	15	lesions	lesion	NNS
10_1101-2021_01_08_423993	24	16	in	in	IN
10_1101-2021_01_08_423993	24	17	vitro	vitro	FW
10_1101-2021_01_08_423993	24	18	,	,	,
10_1101-2021_01_08_423993	24	19	and	and	CC
10_1101-2021_01_08_423993	24	20	is	be	VBZ
10_1101-2021_01_08_423993	24	21	involved	involve	VBN
10_1101-2021_01_08_423993	24	22	in	in	IN
10_1101-2021_01_08_423993	24	23	the	the	DT
10_1101-2021_01_08_423993	24	24	repair	repair	NN
10_1101-2021_01_08_423993	24	25	of	of	IN
10_1101-2021_01_08_423993	24	26	interstrand	interstrand	NNP
10_1101-2021_01_08_423993	24	27	crosslinks	crosslink	NNS
10_1101-2021_01_08_423993	24	28	(	(	-LRB-
10_1101-2021_01_08_423993	24	29	ICLs	ICLs	NNPS
10_1101-2021_01_08_423993	24	30	)	)	-RRB-
10_1101-2021_01_08_423993	24	31	[	[	-LRB-
10_1101-2021_01_08_423993	24	32	9	9	CD
10_1101-2021_01_08_423993	24	33	–	–	SYM
10_1101-2021_01_08_423993	24	34	11	11	CD
10_1101-2021_01_08_423993	24	35	]	]	-RRB-
10_1101-2021_01_08_423993	24	36	.	.	.
10_1101-2021_01_08_423993	25	1	SNM1B	snm1b	LS
10_1101-2021_01_08_423993	25	2	/	/	SYM
10_1101-2021_01_08_423993	25	3	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	25	4	is	be	VBZ
10_1101-2021_01_08_423993	25	5	a	a	DT
10_1101-2021_01_08_423993	25	6	shelterin	shelterin	NN
10_1101-2021_01_08_423993	25	7	-	-	HYPH
10_1101-2021_01_08_423993	25	8	associated	associate	VBN
10_1101-2021_01_08_423993	25	9	protein	protein	NN
10_1101-2021_01_08_423993	25	10	required	require	VBN
10_1101-2021_01_08_423993	25	11	for	for	IN
10_1101-2021_01_08_423993	25	12	resection	resection	NN
10_1101-2021_01_08_423993	25	13	at	at	IN
10_1101-2021_01_08_423993	25	14	newly-	newly-	NNP
10_1101-2021_01_08_423993	25	15	replicated	replicate	VBN
10_1101-2021_01_08_423993	25	16	leading	leading	JJ
10_1101-2021_01_08_423993	25	17	-	-	HYPH
10_1101-2021_01_08_423993	25	18	strand	strand	JJ
10_1101-2021_01_08_423993	25	19	telomeres	telomere	NNS
10_1101-2021_01_08_423993	25	20	to	to	TO
10_1101-2021_01_08_423993	25	21	generate	generate	VB
10_1101-2021_01_08_423993	25	22	the	the	DT
10_1101-2021_01_08_423993	25	23	3'-overhang	3'-overhang	NNP
10_1101-2021_01_08_423993	25	24	necessary	necessary	JJ
10_1101-2021_01_08_423993	25	25	for	for	IN
10_1101-2021_01_08_423993	25	26	telomere	telomere	JJ
10_1101-2021_01_08_423993	25	27	loop	loop	NN
10_1101-2021_01_08_423993	25	28	(	(	-LRB-
10_1101-2021_01_08_423993	25	29	t	t	NNP
10_1101-2021_01_08_423993	25	30	-	-	HYPH
10_1101-2021_01_08_423993	25	31	loop	loop	NN
10_1101-2021_01_08_423993	25	32	)	)	-RRB-
10_1101-2021_01_08_423993	25	33	formation	formation	NN
10_1101-2021_01_08_423993	25	34	and	and	CC
10_1101-2021_01_08_423993	25	35	telomere	telomere	JJ
10_1101-2021_01_08_423993	25	36	protection	protection	NN
10_1101-2021_01_08_423993	25	37	[	[	-LRB-
10_1101-2021_01_08_423993	25	38	12–14	12–14	CD
10_1101-2021_01_08_423993	25	39	]	]	-RRB-
10_1101-2021_01_08_423993	25	40	.	.	.
10_1101-2021_01_08_423993	26	1	Both	both	DT
10_1101-2021_01_08_423993	26	2	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	26	3	and	and	CC
10_1101-2021_01_08_423993	26	4	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	26	5	/	/	SYM
10_1101-2021_01_08_423993	26	6	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	26	7	prefer	prefer	VBP
10_1101-2021_01_08_423993	26	8	ssDNA	ssdna	NN
10_1101-2021_01_08_423993	26	9	substrates	substrate	NNS
10_1101-2021_01_08_423993	26	10	in	in	IN
10_1101-2021_01_08_423993	26	11	vitro	vitro	FW
10_1101-2021_01_08_423993	26	12	,	,	,
10_1101-2021_01_08_423993	26	13	with	with	IN
10_1101-2021_01_08_423993	26	14	an	an	DT
10_1101-2021_01_08_423993	26	15	absolute	absolute	JJ
10_1101-2021_01_08_423993	26	16	requirement	requirement	NN
10_1101-2021_01_08_423993	26	17	for	for	IN
10_1101-2021_01_08_423993	26	18	a	a	DT
10_1101-2021_01_08_423993	26	19	free	free	JJ
10_1101-2021_01_08_423993	26	20	5'-phosphate	5'-phosphate	NNP
10_1101-2021_01_08_423993	26	21	[	[	-LRB-
10_1101-2021_01_08_423993	26	22	3,15	3,15	CD
10_1101-2021_01_08_423993	26	23	]	]	-RRB-
10_1101-2021_01_08_423993	26	24	.	.	.
10_1101-2021_01_08_423993	27	1	By	by	IN
10_1101-2021_01_08_423993	27	2	contrast	contrast	NN
10_1101-2021_01_08_423993	27	3	,	,	,
10_1101-2021_01_08_423993	27	4	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	27	5	prefers	prefer	VBZ
10_1101-2021_01_08_423993	27	6	hairpins	hairpin	NNS
10_1101-2021_01_08_423993	27	7	and	and	CC
10_1101-2021_01_08_423993	27	8	DNA	dna	NN
10_1101-2021_01_08_423993	27	9	junctions	junction	NNS
10_1101-2021_01_08_423993	27	10	as	as	IN
10_1101-2021_01_08_423993	27	11	substrates	substrate	NNS
10_1101-2021_01_08_423993	27	12	for	for	IN
10_1101-2021_01_08_423993	27	13	its	-PRON-	PRP$
10_1101-2021_01_08_423993	27	14	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	27	15	activity	activity	NN
10_1101-2021_01_08_423993	27	16	,	,	,
10_1101-2021_01_08_423993	27	17	although	although	IN
10_1101-2021_01_08_423993	27	18	it	-PRON-	PRP
10_1101-2021_01_08_423993	27	19	is	be	VBZ
10_1101-2021_01_08_423993	27	20	able	able	JJ
10_1101-2021_01_08_423993	27	21	to	to	TO
10_1101-2021_01_08_423993	27	22	process	process	VB
10_1101-2021_01_08_423993	27	23	ssDNA	ssDNA	NNP
10_1101-2021_01_08_423993	27	24	substrates	substrate	NNS
10_1101-2021_01_08_423993	27	25	[	[	-LRB-
10_1101-2021_01_08_423993	27	26	16–18	16–18	NN
10_1101-2021_01_08_423993	27	27	]	]	-RRB-
10_1101-2021_01_08_423993	27	28	The	the	DT
10_1101-2021_01_08_423993	27	29	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	27	30	activity	activity	NN
10_1101-2021_01_08_423993	27	31	of	of	IN
10_1101-2021_01_08_423993	27	32	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	27	33	is	be	VBZ
10_1101-2021_01_08_423993	27	34	responsible	responsible	JJ
10_1101-2021_01_08_423993	27	35	for	for	IN
10_1101-2021_01_08_423993	27	36	hairpin	hairpin	NN
10_1101-2021_01_08_423993	27	37	opening	opening	NN
10_1101-2021_01_08_423993	27	38	in	in	IN
10_1101-2021_01_08_423993	27	39	variable	variable	JJ
10_1101-2021_01_08_423993	27	40	(	(	-LRB-
10_1101-2021_01_08_423993	27	41	diversity	diversity	NN
10_1101-2021_01_08_423993	27	42	)	)	-RRB-
10_1101-2021_01_08_423993	27	43	joining	join	VBG
10_1101-2021_01_08_423993	27	44	(	(	-LRB-
10_1101-2021_01_08_423993	27	45	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	27	46	)	)	-RRB-
10_1101-2021_01_08_423993	27	47	recombination	recombination	NN
10_1101-2021_01_08_423993	27	48	[	[	-LRB-
10_1101-2021_01_08_423993	27	49	19	19	CD
10_1101-2021_01_08_423993	27	50	]	]	-RRB-
10_1101-2021_01_08_423993	27	51	and	and	CC
10_1101-2021_01_08_423993	27	52	contributes	contribute	VBZ
10_1101-2021_01_08_423993	27	53	to	to	TO
10_1101-2021_01_08_423993	27	54	end	end	NN
10_1101-2021_01_08_423993	27	55	-	-	HYPH
10_1101-2021_01_08_423993	27	56	processing	processing	NN
10_1101-2021_01_08_423993	27	57	in	in	IN
10_1101-2021_01_08_423993	27	58	the	the	DT
10_1101-2021_01_08_423993	27	59	canonical	canonical	JJ
10_1101-2021_01_08_423993	27	60	non	non	JJ
10_1101-2021_01_08_423993	27	61	-	-	JJ
10_1101-2021_01_08_423993	27	62	homologous	homologous	JJ
10_1101-2021_01_08_423993	27	63	end	end	NN
10_1101-2021_01_08_423993	27	64	joining	joining	NN
10_1101-2021_01_08_423993	27	65	(	(	-LRB-
10_1101-2021_01_08_423993	27	66	c	c	NNP
10_1101-2021_01_08_423993	27	67	-	-	:
10_1101-2021_01_08_423993	27	68	NHEJ	NHEJ	NNP
10_1101-2021_01_08_423993	27	69	)	)	-RRB-
10_1101-2021_01_08_423993	27	70	DNA	dna	NN
10_1101-2021_01_08_423993	27	71	repair	repair	NN
10_1101-2021_01_08_423993	27	72	[	[	-LRB-
10_1101-2021_01_08_423993	27	73	20–23	20–23	CD
10_1101-2021_01_08_423993	27	74	]	]	-RRB-
10_1101-2021_01_08_423993	27	75	.	.	.
10_1101-2021_01_08_423993	28	1	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	28	2	recombination	recombination	NN
10_1101-2021_01_08_423993	28	3	is	be	VBZ
10_1101-2021_01_08_423993	28	4	initiated	initiate	VBN
10_1101-2021_01_08_423993	28	5	by	by	IN
10_1101-2021_01_08_423993	28	6	the	the	DT
10_1101-2021_01_08_423993	28	7	recognition	recognition	NN
10_1101-2021_01_08_423993	28	8	and	and	CC
10_1101-2021_01_08_423993	28	9	binding	binding	NN
10_1101-2021_01_08_423993	28	10	of	of	IN
10_1101-2021_01_08_423993	28	11	recombination	recombination	NN
10_1101-2021_01_08_423993	28	12	-	-	HYPH
10_1101-2021_01_08_423993	28	13	activating	activate	VBG
10_1101-2021_01_08_423993	28	14	gene	gene	NN
10_1101-2021_01_08_423993	28	15	proteins	protein	NNS
10_1101-2021_01_08_423993	28	16	(	(	-LRB-
10_1101-2021_01_08_423993	28	17	RAG1	RAG1	NNP
10_1101-2021_01_08_423993	28	18	and	and	CC
10_1101-2021_01_08_423993	28	19	RAG2	rag2	VB
10_1101-2021_01_08_423993	28	20	)	)	-RRB-
10_1101-2021_01_08_423993	28	21	to	to	IN
10_1101-2021_01_08_423993	28	22	the	the	DT
10_1101-2021_01_08_423993	28	23	recombination	recombination	NN
10_1101-2021_01_08_423993	28	24	signal	signal	NN
10_1101-2021_01_08_423993	28	25	sequences	sequence	NNS
10_1101-2021_01_08_423993	28	26	(	(	-LRB-
10_1101-2021_01_08_423993	28	27	RSSs	RSSs	NNP
10_1101-2021_01_08_423993	28	28	)	)	-RRB-
10_1101-2021_01_08_423993	28	29	adjacent	adjacent	JJ
10_1101-2021_01_08_423993	28	30	to	to	IN
10_1101-2021_01_08_423993	28	31	the	the	DT
10_1101-2021_01_08_423993	28	32	V	v	NN
10_1101-2021_01_08_423993	28	33	,	,	,
10_1101-2021_01_08_423993	28	34	D	d	NN
10_1101-2021_01_08_423993	28	35	,	,	,
10_1101-2021_01_08_423993	28	36	and	and	CC
10_1101-2021_01_08_423993	28	37	J	J	NNP
10_1101-2021_01_08_423993	28	38	gene	gene	NN
10_1101-2021_01_08_423993	28	39	segments	segment	NNS
10_1101-2021_01_08_423993	28	40	.	.	.
10_1101-2021_01_08_423993	29	1	Upon	upon	IN
10_1101-2021_01_08_423993	29	2	binding	bind	VBG
10_1101-2021_01_08_423993	29	3	,	,	,
10_1101-2021_01_08_423993	29	4	the	the	DT
10_1101-2021_01_08_423993	29	5	RAG	RAG	NNP
10_1101-2021_01_08_423993	29	6	proteins	protein	NNS
10_1101-2021_01_08_423993	29	7	induce	induce	VBP
10_1101-2021_01_08_423993	29	8	double	double	JJ
10_1101-2021_01_08_423993	29	9	-	-	HYPH
10_1101-2021_01_08_423993	29	10	strand	strand	NN
10_1101-2021_01_08_423993	29	11	breaks	break	NNS
10_1101-2021_01_08_423993	29	12	(	(	-LRB-
10_1101-2021_01_08_423993	29	13	DSBs	DSBs	NNP
10_1101-2021_01_08_423993	29	14	)	)	-RRB-
10_1101-2021_01_08_423993	29	15	and	and	CC
10_1101-2021_01_08_423993	29	16	create	create	VB
10_1101-2021_01_08_423993	29	17	a	a	DT
10_1101-2021_01_08_423993	29	18	hairpin	hairpin	NN
10_1101-2021_01_08_423993	29	19	at	at	IN
10_1101-2021_01_08_423993	29	20	the	the	DT
10_1101-2021_01_08_423993	29	21	coding	code	VBG
10_1101-2021_01_08_423993	29	22	ends	end	NNS
10_1101-2021_01_08_423993	29	23	[	[	-LRB-
10_1101-2021_01_08_423993	29	24	24–26	24–26	CD
10_1101-2021_01_08_423993	29	25	]	]	-RRB-
10_1101-2021_01_08_423993	29	26	.	.	.
10_1101-2021_01_08_423993	30	1	The	the	DT
10_1101-2021_01_08_423993	30	2	Ku	Ku	NNP
10_1101-2021_01_08_423993	30	3	heterodimer	heterodimer	NN
10_1101-2021_01_08_423993	30	4	recognises	recognise	VBZ
10_1101-2021_01_08_423993	30	5	the	the	DT
10_1101-2021_01_08_423993	30	6	DNA	DNA	NNP
10_1101-2021_01_08_423993	30	7	double-	double-	VBZ
10_1101-2021_01_08_423993	30	8	strand	strand	NNP
10_1101-2021_01_08_423993	30	9	break	break	NN
10_1101-2021_01_08_423993	30	10	and	and	CC
10_1101-2021_01_08_423993	30	11	recruits	recruit	VBZ
10_1101-2021_01_08_423993	30	12	DNA	dna	NN
10_1101-2021_01_08_423993	30	13	-	-	HYPH
10_1101-2021_01_08_423993	30	14	dependent	dependent	JJ
10_1101-2021_01_08_423993	30	15	protein	protein	NN
10_1101-2021_01_08_423993	30	16	kinase	kinase	VBD
10_1101-2021_01_08_423993	30	17	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	30	18	subunit	subunit	NN
10_1101-2021_01_08_423993	30	19	(	(	-LRB-
10_1101-2021_01_08_423993	30	20	DNA	dna	NN
10_1101-2021_01_08_423993	30	21	-	-	HYPH
10_1101-2021_01_08_423993	30	22	PKcs	pkcs	NN
10_1101-2021_01_08_423993	30	23	)	)	-RRB-
10_1101-2021_01_08_423993	30	24	and	and	CC
10_1101-2021_01_08_423993	30	25	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	30	26	to	to	TO
10_1101-2021_01_08_423993	30	27	mediate	mediate	VB
10_1101-2021_01_08_423993	30	28	hairpin	hairpin	NN
10_1101-2021_01_08_423993	30	29	opening	opening	NN
10_1101-2021_01_08_423993	30	30	[	[	-LRB-
10_1101-2021_01_08_423993	30	31	17	17	CD
10_1101-2021_01_08_423993	30	32	]	]	-RRB-
10_1101-2021_01_08_423993	30	33	.	.	.
10_1101-2021_01_08_423993	31	1	Following	follow	VBG
10_1101-2021_01_08_423993	31	2	hairpin	hairpin	NN
10_1101-2021_01_08_423993	31	3	opening	opening	NN
10_1101-2021_01_08_423993	31	4	,	,	,
10_1101-2021_01_08_423993	31	5	the	the	DT
10_1101-2021_01_08_423993	31	6	NHEJ	NHEJ	NNP
10_1101-2021_01_08_423993	31	7	machinery	machinery	NN
10_1101-2021_01_08_423993	31	8	containing	contain	VBG
10_1101-2021_01_08_423993	31	9	the	the	DT
10_1101-2021_01_08_423993	31	10	XRCC4	XRCC4	NNP
10_1101-2021_01_08_423993	31	11	/	/	SYM
10_1101-2021_01_08_423993	31	12	XLF(PAXX)/DNA	XLF(PAXX)/DNA	NNP
10_1101-2021_01_08_423993	31	13	-	-	HYPH
10_1101-2021_01_08_423993	31	14	Ligase	Ligase	NNP
10_1101-2021_01_08_423993	31	15	IV	IV	NNP
10_1101-2021_01_08_423993	31	16	complex	complex	NN
10_1101-2021_01_08_423993	31	17	is	be	VBZ
10_1101-2021_01_08_423993	31	18	recruited	recruit	VBN
10_1101-2021_01_08_423993	31	19	to	to	TO
10_1101-2021_01_08_423993	31	20	catalyse	catalyse	VB
10_1101-2021_01_08_423993	31	21	the	the	DT
10_1101-2021_01_08_423993	31	22	processing	processing	NN
10_1101-2021_01_08_423993	31	23	and	and	CC
10_1101-2021_01_08_423993	31	24	ligation	ligation	NN
10_1101-2021_01_08_423993	31	25	reactions	reaction	NNS
10_1101-2021_01_08_423993	31	26	of	of	IN
10_1101-2021_01_08_423993	31	27	the	the	DT
10_1101-2021_01_08_423993	31	28	DNA	DNA	NNP
10_1101-2021_01_08_423993	31	29	ends	end	VBZ
10_1101-2021_01_08_423993	31	30	[	[	-LRB-
10_1101-2021_01_08_423993	31	31	20,27,28	20,27,28	CD
10_1101-2021_01_08_423993	31	32	]	]	-RRB-
10_1101-2021_01_08_423993	31	33	.	.	.
10_1101-2021_01_08_423993	32	1	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	32	2	recombination	recombination	NN
10_1101-2021_01_08_423993	32	3	is	be	VBZ
10_1101-2021_01_08_423993	32	4	an	an	DT
10_1101-2021_01_08_423993	32	5	essential	essential	JJ
10_1101-2021_01_08_423993	32	6	process	process	NN
10_1101-2021_01_08_423993	32	7	in	in	IN
10_1101-2021_01_08_423993	32	8	antibody	antibody	NN
10_1101-2021_01_08_423993	32	9	maturation	maturation	NN
10_1101-2021_01_08_423993	32	10	[	[	-LRB-
10_1101-2021_01_08_423993	32	11	16,29,30	16,29,30	CD
10_1101-2021_01_08_423993	32	12	]	]	-RRB-
10_1101-2021_01_08_423993	32	13	.	.	.
10_1101-2021_01_08_423993	33	1	Mutations	mutation	NNS
10_1101-2021_01_08_423993	33	2	in	in	IN
10_1101-2021_01_08_423993	33	3	the	the	DT
10_1101-2021_01_08_423993	33	4	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	33	5	gene	gene	NN
10_1101-2021_01_08_423993	33	6	cause	cause	IN
10_1101-2021_01_08_423993	33	7	aberrant	aberrant	NNP
10_1101-2021_01_08_423993	33	8	hairpin	hairpin	NNP
10_1101-2021_01_08_423993	33	9	opening	opening	NN
10_1101-2021_01_08_423993	33	10	resulting	result	VBG
10_1101-2021_01_08_423993	33	11	in	in	IN
10_1101-2021_01_08_423993	33	12	severe	severe	JJ
10_1101-2021_01_08_423993	33	13	combined	combine	VBN
10_1101-2021_01_08_423993	33	14	immune	immune	JJ
10_1101-2021_01_08_423993	33	15	deficiency	deficiency	NN
10_1101-2021_01_08_423993	33	16	(	(	-LRB-
10_1101-2021_01_08_423993	33	17	RS	RS	NNP
10_1101-2021_01_08_423993	33	18	-	-	HYPH
10_1101-2021_01_08_423993	33	19	SCID	SCID	NNP
10_1101-2021_01_08_423993	33	20	)	)	-RRB-
10_1101-2021_01_08_423993	33	21	,	,	,
10_1101-2021_01_08_423993	33	22	with	with	IN
10_1101-2021_01_08_423993	33	23	sensitivity	sensitivity	NN
10_1101-2021_01_08_423993	33	24	to	to	IN
10_1101-2021_01_08_423993	33	25	ionising	ionise	VBG
10_1101-2021_01_08_423993	33	26	radiation	radiation	NN
10_1101-2021_01_08_423993	33	27	due	due	JJ
10_1101-2021_01_08_423993	33	28	to	to	IN
10_1101-2021_01_08_423993	33	29	impairment	impairment	NN
10_1101-2021_01_08_423993	33	30	of	of	IN
10_1101-2021_01_08_423993	33	31	the	the	DT
10_1101-2021_01_08_423993	33	32	predominant	predominant	JJ
10_1101-2021_01_08_423993	33	33	DSB	DSB	NNP
10_1101-2021_01_08_423993	33	34	repair	repair	NN
10_1101-2021_01_08_423993	33	35	pathway	pathway	NN
10_1101-2021_01_08_423993	33	36	in	in	IN
10_1101-2021_01_08_423993	33	37	mammalian	mammalian	JJ
10_1101-2021_01_08_423993	33	38	cells	cell	NNS
10_1101-2021_01_08_423993	33	39	,	,	,
10_1101-2021_01_08_423993	33	40	NHEJ	NHEJ	NNP
10_1101-2021_01_08_423993	33	41	[	[	-LRB-
10_1101-2021_01_08_423993	33	42	17,19,27	17,19,27	NNP
10_1101-2021_01_08_423993	33	43	]	]	-RRB-
10_1101-2021_01_08_423993	33	44	,	,	,
10_1101-2021_01_08_423993	33	45	and	and	CC
10_1101-2021_01_08_423993	33	46	another	another	DT
10_1101-2021_01_08_423993	33	47	form	form	NN
10_1101-2021_01_08_423993	33	48	of	of	IN
10_1101-2021_01_08_423993	33	49	SCID	SCID	NNP
10_1101-2021_01_08_423993	33	50	(	(	-LRB-
10_1101-2021_01_08_423993	33	51	Omenn	Omenn	NNP
10_1101-2021_01_08_423993	33	52	syndrome	syndrome	NN
10_1101-2021_01_08_423993	33	53	)	)	-RRB-
10_1101-2021_01_08_423993	33	54	associated	associate	VBN
10_1101-2021_01_08_423993	33	55	with	with	IN
10_1101-2021_01_08_423993	33	56	hypomorphic	hypomorphic	JJ
10_1101-2021_01_08_423993	33	57	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	33	58	mutations	mutation	NNS
10_1101-2021_01_08_423993	33	59	[	[	-LRB-
10_1101-2021_01_08_423993	33	60	31,32	31,32	CD
10_1101-2021_01_08_423993	33	61	]	]	-RRB-
10_1101-2021_01_08_423993	33	62	.CC	.CC	:
10_1101-2021_01_08_423993	33	63	-	-	:
10_1101-2021_01_08_423993	33	64	BY	by	IN
10_1101-2021_01_08_423993	33	65	4.0	4.0	CD
10_1101-2021_01_08_423993	33	66	International	international	JJ
10_1101-2021_01_08_423993	33	67	licensemade	licensemade	NN
10_1101-2021_01_08_423993	33	68	available	available	JJ
10_1101-2021_01_08_423993	33	69	under	under	IN
10_1101-2021_01_08_423993	33	70	a	a	DT
10_1101-2021_01_08_423993	33	71	(	(	-LRB-
10_1101-2021_01_08_423993	33	72	which	which	WDT
10_1101-2021_01_08_423993	33	73	was	be	VBD
10_1101-2021_01_08_423993	33	74	not	not	RB
10_1101-2021_01_08_423993	33	75	certified	certify	VBN
10_1101-2021_01_08_423993	33	76	by	by	IN
10_1101-2021_01_08_423993	33	77	peer	peer	NN
10_1101-2021_01_08_423993	33	78	review	review	NN
10_1101-2021_01_08_423993	33	79	)	)	-RRB-
10_1101-2021_01_08_423993	33	80	is	be	VBZ
10_1101-2021_01_08_423993	33	81	the	the	DT
10_1101-2021_01_08_423993	33	82	author	author	NN
10_1101-2021_01_08_423993	33	83	/	/	SYM
10_1101-2021_01_08_423993	33	84	funder	funder	NN
10_1101-2021_01_08_423993	33	85	,	,	,
10_1101-2021_01_08_423993	33	86	who	who	WP
10_1101-2021_01_08_423993	33	87	has	have	VBZ
10_1101-2021_01_08_423993	33	88	granted	grant	VBN
10_1101-2021_01_08_423993	33	89	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	33	90	a	a	DT
10_1101-2021_01_08_423993	33	91	license	license	NN
10_1101-2021_01_08_423993	33	92	to	to	TO
10_1101-2021_01_08_423993	33	93	display	display	VB
10_1101-2021_01_08_423993	33	94	the	the	DT
10_1101-2021_01_08_423993	33	95	preprint	preprint	NN
10_1101-2021_01_08_423993	33	96	in	in	IN
10_1101-2021_01_08_423993	33	97	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	33	98	.	.	.
10_1101-2021_01_08_423993	34	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	34	2	is	be	VBZ
10_1101-2021_01_08_423993	34	3	The	the	DT
10_1101-2021_01_08_423993	34	4	copyright	copyright	NN
10_1101-2021_01_08_423993	34	5	holder	holder	NN
10_1101-2021_01_08_423993	34	6	for	for	IN
10_1101-2021_01_08_423993	34	7	this	this	DT
10_1101-2021_01_08_423993	34	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	34	9	version	version	NN
10_1101-2021_01_08_423993	34	10	posted	post	VBD
10_1101-2021_01_08_423993	34	11	January	January	NNP
10_1101-2021_01_08_423993	34	12	8	8	CD
10_1101-2021_01_08_423993	34	13	,	,	,
10_1101-2021_01_08_423993	34	14	2021	2021	CD
10_1101-2021_01_08_423993	34	15	.	.	.
10_1101-2021_01_08_423993	34	16	;	;	:
10_1101-2021_01_08_423993	34	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	34	18	:	:	:
10_1101-2021_01_08_423993	34	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	34	20	preprint	preprint	NN
10_1101-2021_01_08_423993	34	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	34	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2021_01_08_423993	34	23	One	one	CD
10_1101-2021_01_08_423993	34	24	of	of	IN
10_1101-2021_01_08_423993	34	25	the	the	DT
10_1101-2021_01_08_423993	34	26	most	most	RBS
10_1101-2021_01_08_423993	34	27	common	common	JJ
10_1101-2021_01_08_423993	34	28	mutations	mutation	NNS
10_1101-2021_01_08_423993	34	29	leading	lead	VBG
10_1101-2021_01_08_423993	34	30	to	to	IN
10_1101-2021_01_08_423993	34	31	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	34	32	loss	loss	NN
10_1101-2021_01_08_423993	34	33	-	-	HYPH
10_1101-2021_01_08_423993	34	34	of	of	IN
10_1101-2021_01_08_423993	34	35	-	-	HYPH
10_1101-2021_01_08_423993	34	36	function	function	NN
10_1101-2021_01_08_423993	34	37	are	be	VBP
10_1101-2021_01_08_423993	34	38	large	large	JJ
10_1101-2021_01_08_423993	34	39	deletions	deletion	NNS
10_1101-2021_01_08_423993	34	40	in	in	IN
10_1101-2021_01_08_423993	34	41	the	the	DT
10_1101-2021_01_08_423993	34	42	first	first	JJ
10_1101-2021_01_08_423993	34	43	four	four	CD
10_1101-2021_01_08_423993	34	44	exons	exon	NNS
10_1101-2021_01_08_423993	34	45	and	and	CC
10_1101-2021_01_08_423993	34	46	a	a	DT
10_1101-2021_01_08_423993	34	47	nonsense	nonsense	NN
10_1101-2021_01_08_423993	34	48	founder	founder	NN
10_1101-2021_01_08_423993	34	49	mutation	mutation	NN
10_1101-2021_01_08_423993	34	50	,	,	,
10_1101-2021_01_08_423993	34	51	as	as	IN
10_1101-2021_01_08_423993	34	52	found	find	VBN
10_1101-2021_01_08_423993	34	53	in	in	IN
10_1101-2021_01_08_423993	34	54	Navajo	Navajo	NNP
10_1101-2021_01_08_423993	34	55	and	and	CC
10_1101-2021_01_08_423993	34	56	Apache	Apache	NNP
10_1101-2021_01_08_423993	34	57	Native	Native	NNP
10_1101-2021_01_08_423993	34	58	Americans	Americans	NNPS
10_1101-2021_01_08_423993	34	59	[	[	-LRB-
10_1101-2021_01_08_423993	34	60	33	33	CD
10_1101-2021_01_08_423993	34	61	]	]	-RRB-
10_1101-2021_01_08_423993	34	62	.	.	.
10_1101-2021_01_08_423993	35	1	In	in	IN
10_1101-2021_01_08_423993	35	2	addition	addition	NN
10_1101-2021_01_08_423993	35	3	,	,	,
10_1101-2021_01_08_423993	35	4	missense	missense	NN
10_1101-2021_01_08_423993	35	5	mutations	mutation	NNS
10_1101-2021_01_08_423993	35	6	and	and	CC
10_1101-2021_01_08_423993	35	7	in	in	IN
10_1101-2021_01_08_423993	35	8	-	-	HYPH
10_1101-2021_01_08_423993	35	9	frame	frame	NN
10_1101-2021_01_08_423993	35	10	deletions	deletion	NNS
10_1101-2021_01_08_423993	35	11	in	in	IN
10_1101-2021_01_08_423993	35	12	the	the	DT
10_1101-2021_01_08_423993	35	13	highly	highly	RB
10_1101-2021_01_08_423993	35	14	conserved	conserve	VBN
10_1101-2021_01_08_423993	35	15	residues	residue	NNS
10_1101-2021_01_08_423993	35	16	such	such	JJ
10_1101-2021_01_08_423993	35	17	as	as	IN
10_1101-2021_01_08_423993	35	18	H35	H35	NNP
10_1101-2021_01_08_423993	35	19	,	,	,
10_1101-2021_01_08_423993	35	20	D165	D165	NNP
10_1101-2021_01_08_423993	35	21	and	and	CC
10_1101-2021_01_08_423993	35	22	H228	H228	NNP
10_1101-2021_01_08_423993	35	23	can	can	MD
10_1101-2021_01_08_423993	35	24	also	also	RB
10_1101-2021_01_08_423993	35	25	abolish	abolish	VB
10_1101-2021_01_08_423993	35	26	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	35	27	’	’	POS
10_1101-2021_01_08_423993	35	28	protein	protein	NN
10_1101-2021_01_08_423993	35	29	function	function	NN
10_1101-2021_01_08_423993	35	30	[	[	-LRB-
10_1101-2021_01_08_423993	35	31	34	34	CD
10_1101-2021_01_08_423993	35	32	]	]	-RRB-
10_1101-2021_01_08_423993	35	33	.	.	.
10_1101-2021_01_08_423993	36	1	Owing	owe	VBG
10_1101-2021_01_08_423993	36	2	to	to	IN
10_1101-2021_01_08_423993	36	3	the	the	DT
10_1101-2021_01_08_423993	36	4	key	key	JJ
10_1101-2021_01_08_423993	36	5	roles	role	NNS
10_1101-2021_01_08_423993	36	6	of	of	IN
10_1101-2021_01_08_423993	36	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	36	8	and	and	CC
10_1101-2021_01_08_423993	36	9	related	relate	VBN
10_1101-2021_01_08_423993	36	10	DSB	DSB	NNP
10_1101-2021_01_08_423993	36	11	repair	repair	NN
10_1101-2021_01_08_423993	36	12	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	36	13	in	in	IN
10_1101-2021_01_08_423993	36	14	both	both	DT
10_1101-2021_01_08_423993	36	15	programmed	program	VBD
10_1101-2021_01_08_423993	36	16	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	36	17	recombination	recombination	NN
10_1101-2021_01_08_423993	36	18	and	and	CC
10_1101-2021_01_08_423993	36	19	non	non	JJ
10_1101-2021_01_08_423993	36	20	-	-	JJ
10_1101-2021_01_08_423993	36	21	programmed	programmed	JJ
10_1101-2021_01_08_423993	36	22	c	c	NNP
10_1101-2021_01_08_423993	36	23	-	-	HYPH
10_1101-2021_01_08_423993	36	24	NHEJ	NHEJ	NNP
10_1101-2021_01_08_423993	36	25	DSB	DSB	NNP
10_1101-2021_01_08_423993	36	26	repair	repair	NN
10_1101-2021_01_08_423993	36	27	,	,	,
10_1101-2021_01_08_423993	36	28	they	-PRON-	PRP
10_1101-2021_01_08_423993	36	29	are	be	VBP
10_1101-2021_01_08_423993	36	30	attractive	attractive	JJ
10_1101-2021_01_08_423993	36	31	pharmacological	pharmacological	JJ
10_1101-2021_01_08_423993	36	32	targets	target	NNS
10_1101-2021_01_08_423993	36	33	for	for	IN
10_1101-2021_01_08_423993	36	34	the	the	DT
10_1101-2021_01_08_423993	36	35	radiosensitisation	radiosensitisation	NN
10_1101-2021_01_08_423993	36	36	of	of	IN
10_1101-2021_01_08_423993	36	37	tumours	tumour	NNS
10_1101-2021_01_08_423993	36	38	.	.	.
10_1101-2021_01_08_423993	37	1	Here	here	RB
10_1101-2021_01_08_423993	37	2	,	,	,
10_1101-2021_01_08_423993	37	3	we	-PRON-	PRP
10_1101-2021_01_08_423993	37	4	present	present	VBP
10_1101-2021_01_08_423993	37	5	a	a	DT
10_1101-2021_01_08_423993	37	6	high	high	JJ
10_1101-2021_01_08_423993	37	7	-	-	HYPH
10_1101-2021_01_08_423993	37	8	resolution	resolution	NN
10_1101-2021_01_08_423993	37	9	crystal	crystal	NN
10_1101-2021_01_08_423993	37	10	structure	structure	NN
10_1101-2021_01_08_423993	37	11	of	of	IN
10_1101-2021_01_08_423993	37	12	the	the	DT
10_1101-2021_01_08_423993	37	13	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	37	14	core	core	NN
10_1101-2021_01_08_423993	37	15	of	of	IN
10_1101-2021_01_08_423993	37	16	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	37	17	(	(	-LRB-
10_1101-2021_01_08_423993	37	18	aa1	aa1	NNP
10_1101-2021_01_08_423993	37	19	–	–	:
10_1101-2021_01_08_423993	37	20	361	361	CD
10_1101-2021_01_08_423993	37	21	)	)	-RRB-
10_1101-2021_01_08_423993	37	22	containing	contain	VBG
10_1101-2021_01_08_423993	37	23	both	both	CC
10_1101-2021_01_08_423993	37	24	MBL	MBL	NNP
10_1101-2021_01_08_423993	37	25	and	and	CC
10_1101-2021_01_08_423993	37	26	a	a	DT
10_1101-2021_01_08_423993	37	27	β	β	NNP
10_1101-2021_01_08_423993	37	28	-	-	HYPH
10_1101-2021_01_08_423993	37	29	CASP	casp	JJ
10_1101-2021_01_08_423993	37	30	domains	domain	NNS
10_1101-2021_01_08_423993	37	31	.	.	.
10_1101-2021_01_08_423993	38	1	This	this	DT
10_1101-2021_01_08_423993	38	2	reveals	reveal	VBZ
10_1101-2021_01_08_423993	38	3	that	that	IN
10_1101-2021_01_08_423993	38	4	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	38	5	possesses	possess	VBZ
10_1101-2021_01_08_423993	38	6	a	a	DT
10_1101-2021_01_08_423993	38	7	unique	unique	JJ
10_1101-2021_01_08_423993	38	8	feature	feature	NN
10_1101-2021_01_08_423993	38	9	,	,	,
10_1101-2021_01_08_423993	38	10	that	that	DT
10_1101-2021_01_08_423993	38	11	is	be	VBZ
10_1101-2021_01_08_423993	38	12	not	not	RB
10_1101-2021_01_08_423993	38	13	present	present	JJ
10_1101-2021_01_08_423993	38	14	in	in	IN
10_1101-2021_01_08_423993	38	15	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	38	16	and	and	CC
10_1101-2021_01_08_423993	38	17	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	38	18	/	/	SYM
10_1101-2021_01_08_423993	38	19	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	38	20	,	,	,
10_1101-2021_01_08_423993	38	21	i.e.	i.e.	FW
10_1101-2021_01_08_423993	38	22	,	,	,
10_1101-2021_01_08_423993	38	23	a	a	DT
10_1101-2021_01_08_423993	38	24	second	second	JJ
10_1101-2021_01_08_423993	38	25	metal	metal	NN
10_1101-2021_01_08_423993	38	26	binding	bind	VBG
10_1101-2021_01_08_423993	38	27	site	site	NN
10_1101-2021_01_08_423993	38	28	in	in	IN
10_1101-2021_01_08_423993	38	29	its	-PRON-	PRP$
10_1101-2021_01_08_423993	38	30	β	β	NNP
10_1101-2021_01_08_423993	38	31	-	-	HYPH
10_1101-2021_01_08_423993	38	32	CASP	CASP	NNP
10_1101-2021_01_08_423993	38	33	domain	domain	NN
10_1101-2021_01_08_423993	38	34	that	that	WDT
10_1101-2021_01_08_423993	38	35	bears	bear	VBZ
10_1101-2021_01_08_423993	38	36	a	a	DT
10_1101-2021_01_08_423993	38	37	resemblance	resemblance	NN
10_1101-2021_01_08_423993	38	38	to	to	IN
10_1101-2021_01_08_423993	38	39	classical	classical	JJ
10_1101-2021_01_08_423993	38	40	Cys2His2	Cys2His2	NNP
10_1101-2021_01_08_423993	38	41	zinc	zinc	NNP
10_1101-2021_01_08_423993	38	42	finger	finger	NN
10_1101-2021_01_08_423993	38	43	motifs	motif	VBZ
10_1101-2021_01_08_423993	38	44	.	.	.
10_1101-2021_01_08_423993	39	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	39	2	propose	propose	VBP
10_1101-2021_01_08_423993	39	3	that	that	IN
10_1101-2021_01_08_423993	39	4	this	this	DT
10_1101-2021_01_08_423993	39	5	second	second	JJ
10_1101-2021_01_08_423993	39	6	metal	metal	NN
10_1101-2021_01_08_423993	39	7	coordination	coordination	NN
10_1101-2021_01_08_423993	39	8	site	site	NN
10_1101-2021_01_08_423993	39	9	is	be	VBZ
10_1101-2021_01_08_423993	39	10	involved	involve	VBN
10_1101-2021_01_08_423993	39	11	in	in	IN
10_1101-2021_01_08_423993	39	12	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	39	13	stabilisation	stabilisation	NN
10_1101-2021_01_08_423993	39	14	and	and	CC
10_1101-2021_01_08_423993	39	15	substrate	substrate	NN
10_1101-2021_01_08_423993	39	16	specificity	specificity	NN
10_1101-2021_01_08_423993	39	17	.	.	.
10_1101-2021_01_08_423993	40	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	40	2	also	also	RB
10_1101-2021_01_08_423993	40	3	present	present	VBP
10_1101-2021_01_08_423993	40	4	a	a	DT
10_1101-2021_01_08_423993	40	5	model	model	NN
10_1101-2021_01_08_423993	40	6	for	for	IN
10_1101-2021_01_08_423993	40	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	40	8	DNA	DNA	NNP
10_1101-2021_01_08_423993	40	9	binding	bind	VBG
10_1101-2021_01_08_423993	40	10	based	base	VBN
10_1101-2021_01_08_423993	40	11	on	on	IN
10_1101-2021_01_08_423993	40	12	our	-PRON-	PRP$
10_1101-2021_01_08_423993	40	13	data	datum	NNS
10_1101-2021_01_08_423993	40	14	and	and	CC
10_1101-2021_01_08_423993	40	15	another	another	DT
10_1101-2021_01_08_423993	40	16	recently	recently	RB
10_1101-2021_01_08_423993	40	17	published	publish	VBN
10_1101-2021_01_08_423993	40	18	structure	structure	NN
10_1101-2021_01_08_423993	40	19	.	.	.
10_1101-2021_01_08_423993	41	1	The	the	DT
10_1101-2021_01_08_423993	41	2	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	41	3	DNA	dna	NN
10_1101-2021_01_08_423993	41	4	model	model	NN
10_1101-2021_01_08_423993	41	5	is	be	VBZ
10_1101-2021_01_08_423993	41	6	compared	compare	VBN
10_1101-2021_01_08_423993	41	7	with	with	IN
10_1101-2021_01_08_423993	41	8	models	model	NNS
10_1101-2021_01_08_423993	41	9	of	of	IN
10_1101-2021_01_08_423993	41	10	DNA	dna	NN
10_1101-2021_01_08_423993	41	11	binding	bind	VBG
10_1101-2021_01_08_423993	41	12	from	from	IN
10_1101-2021_01_08_423993	41	13	related	related	JJ
10_1101-2021_01_08_423993	41	14	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	41	15	to	to	TO
10_1101-2021_01_08_423993	41	16	reveal	reveal	VB
10_1101-2021_01_08_423993	41	17	distinct	distinct	JJ
10_1101-2021_01_08_423993	41	18	features	feature	NNS
10_1101-2021_01_08_423993	41	19	that	that	WDT
10_1101-2021_01_08_423993	41	20	define	define	VBP
10_1101-2021_01_08_423993	41	21	a	a	DT
10_1101-2021_01_08_423993	41	22	role	role	NN
10_1101-2021_01_08_423993	41	23	for	for	IN
10_1101-2021_01_08_423993	41	24	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	41	25	in	in	IN
10_1101-2021_01_08_423993	41	26	the	the	DT
10_1101-2021_01_08_423993	41	27	end	end	NN
10_1101-2021_01_08_423993	41	28	-	-	HYPH
10_1101-2021_01_08_423993	41	29	joining	join	VBG
10_1101-2021_01_08_423993	41	30	reaction	reaction	NN
10_1101-2021_01_08_423993	41	31	.	.	.
10_1101-2021_01_08_423993	42	1	Following	follow	VBG
10_1101-2021_01_08_423993	42	2	development	development	NN
10_1101-2021_01_08_423993	42	3	of	of	IN
10_1101-2021_01_08_423993	42	4	an	an	DT
10_1101-2021_01_08_423993	42	5	assay	assay	NN
10_1101-2021_01_08_423993	42	6	suitable	suitable	JJ
10_1101-2021_01_08_423993	42	7	for	for	IN
10_1101-2021_01_08_423993	42	8	inhibitor	inhibitor	NN
10_1101-2021_01_08_423993	42	9	screens	screen	NNS
10_1101-2021_01_08_423993	42	10	,	,	,
10_1101-2021_01_08_423993	42	11	we	-PRON-	PRP
10_1101-2021_01_08_423993	42	12	identified	identify	VBD
10_1101-2021_01_08_423993	42	13	drug	drug	NN
10_1101-2021_01_08_423993	42	14	-	-	HYPH
10_1101-2021_01_08_423993	42	15	like	like	JJ
10_1101-2021_01_08_423993	42	16	molecules	molecule	NNS
10_1101-2021_01_08_423993	42	17	that	that	WDT
10_1101-2021_01_08_423993	42	18	could	could	MD
10_1101-2021_01_08_423993	42	19	potentially	potentially	RB
10_1101-2021_01_08_423993	42	20	inhibit	inhibit	VB
10_1101-2021_01_08_423993	42	21	both	both	DT
10_1101-2021_01_08_423993	42	22	the	the	DT
10_1101-2021_01_08_423993	42	23	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	42	24	active	active	JJ
10_1101-2021_01_08_423993	42	25	site	site	NN
10_1101-2021_01_08_423993	42	26	and	and	CC
10_1101-2021_01_08_423993	42	27	its	-PRON-	PRP$
10_1101-2021_01_08_423993	42	28	essential	essential	JJ
10_1101-2021_01_08_423993	42	29	zinc	zinc	NN
10_1101-2021_01_08_423993	42	30	finger	finger	NN
10_1101-2021_01_08_423993	42	31	-	-	HYPH
10_1101-2021_01_08_423993	42	32	like	like	JJ
10_1101-2021_01_08_423993	42	33	motif	motif	NN
10_1101-2021_01_08_423993	42	34	.	.	.
10_1101-2021_01_08_423993	43	1	MATERIAL	material	NN
10_1101-2021_01_08_423993	43	2	AND	and	CC
10_1101-2021_01_08_423993	43	3	METHODS	methods	JJ
10_1101-2021_01_08_423993	43	4	Cloning	cloning	NN
10_1101-2021_01_08_423993	43	5	and	and	CC
10_1101-2021_01_08_423993	43	6	site	site	NN
10_1101-2021_01_08_423993	43	7	directed	direct	VBD
10_1101-2021_01_08_423993	43	8	mutagenesis	mutagenesis	NN
10_1101-2021_01_08_423993	43	9	of	of	IN
10_1101-2021_01_08_423993	43	10	WT	WT	NNP
10_1101-2021_01_08_423993	43	11	and	and	CC
10_1101-2021_01_08_423993	43	12	mutant	mutant	NN
10_1101-2021_01_08_423993	43	13	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	43	14	(	(	-LRB-
10_1101-2021_01_08_423993	43	15	aa	aa	NNP
10_1101-2021_01_08_423993	43	16	1	1	CD
10_1101-2021_01_08_423993	43	17	-	-	SYM
10_1101-2021_01_08_423993	43	18	362	362	CD
10_1101-2021_01_08_423993	43	19	)	)	-RRB-
10_1101-2021_01_08_423993	43	20	The	the	DT
10_1101-2021_01_08_423993	43	21	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	43	22	MBL	MBL	NNP
10_1101-2021_01_08_423993	43	23	-	-	HYPH
10_1101-2021_01_08_423993	43	24	β	β	NNP
10_1101-2021_01_08_423993	43	25	-	-	HYPH
10_1101-2021_01_08_423993	43	26	CASP	CASP	NNP
10_1101-2021_01_08_423993	43	27	domain	domain	NN
10_1101-2021_01_08_423993	43	28	(	(	-LRB-
10_1101-2021_01_08_423993	43	29	WT	WT	NNP
10_1101-2021_01_08_423993	43	30	and	and	CC
10_1101-2021_01_08_423993	43	31	mutant	mutant	NN
10_1101-2021_01_08_423993	43	32	)	)	-RRB-
10_1101-2021_01_08_423993	43	33	encoding	encoding	NN
10_1101-2021_01_08_423993	43	34	constructs	construct	NNS
10_1101-2021_01_08_423993	43	35	were	be	VBD
10_1101-2021_01_08_423993	43	36	cloned	clone	VBN
10_1101-2021_01_08_423993	43	37	into	into	IN
10_1101-2021_01_08_423993	43	38	the	the	DT
10_1101-2021_01_08_423993	43	39	baculovirus	baculovirus	NNP
10_1101-2021_01_08_423993	43	40	expression	expression	NN
10_1101-2021_01_08_423993	43	41	vector	vector	NN
10_1101-2021_01_08_423993	43	42	pBF-6HZB	pBF-6HZB	NNP
10_1101-2021_01_08_423993	43	43	which	which	WDT
10_1101-2021_01_08_423993	43	44	combines	combine	VBZ
10_1101-2021_01_08_423993	43	45	an	an	DT
10_1101-2021_01_08_423993	43	46	N	n	NN
10_1101-2021_01_08_423993	43	47	-	-	HYPH
10_1101-2021_01_08_423993	43	48	terminal	terminal	NN
10_1101-2021_01_08_423993	43	49	His6	His6	NNP
10_1101-2021_01_08_423993	43	50	sequence	sequence	NN
10_1101-2021_01_08_423993	43	51	and	and	CC
10_1101-2021_01_08_423993	43	52	the	the	DT
10_1101-2021_01_08_423993	43	53	Z	z	JJ
10_1101-2021_01_08_423993	43	54	-	-	HYPH
10_1101-2021_01_08_423993	43	55	basic	basic	JJ
10_1101-2021_01_08_423993	43	56	tag	tag	NN
10_1101-2021_01_08_423993	43	57	(	(	-LRB-
10_1101-2021_01_08_423993	43	58	GenBankTM	genbanktm	CD
10_1101-2021_01_08_423993	43	59	accession	accession	NN
10_1101-2021_01_08_423993	43	60	number	number	NN
10_1101-2021_01_08_423993	43	61	KP233213.1	kp233213.1	IN
10_1101-2021_01_08_423993	43	62	)	)	-RRB-
10_1101-2021_01_08_423993	43	63	for	for	IN
10_1101-2021_01_08_423993	43	64	efficient	efficient	JJ
10_1101-2021_01_08_423993	43	65	purification	purification	NN
10_1101-2021_01_08_423993	43	66	and	and	CC
10_1101-2021_01_08_423993	43	67	to	to	TO
10_1101-2021_01_08_423993	43	68	promote	promote	VB
10_1101-2021_01_08_423993	43	69	solubility	solubility	NN
10_1101-2021_01_08_423993	43	70	.	.	.
10_1101-2021_01_08_423993	44	1	The	the	DT
10_1101-2021_01_08_423993	44	2	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	44	3	gene	gene	NN
10_1101-2021_01_08_423993	44	4	was	be	VBD
10_1101-2021_01_08_423993	44	5	cloned	clone	VBN
10_1101-2021_01_08_423993	44	6	using	use	VBG
10_1101-2021_01_08_423993	44	7	ligation	ligation	NN
10_1101-2021_01_08_423993	44	8	independent	independent	JJ
10_1101-2021_01_08_423993	44	9	cloning	cloning	NN
10_1101-2021_01_08_423993	44	10	(	(	-LRB-
10_1101-2021_01_08_423993	44	11	LIC	lic	NN
10_1101-2021_01_08_423993	44	12	)	)	-RRB-
10_1101-2021_01_08_423993	44	13	[	[	-LRB-
10_1101-2021_01_08_423993	44	14	35	35	CD
10_1101-2021_01_08_423993	44	15	]	]	-RRB-
10_1101-2021_01_08_423993	44	16	.	.	.
10_1101-2021_01_08_423993	45	1	Site	site	NN
10_1101-2021_01_08_423993	45	2	directed	direct	VBN
10_1101-2021_01_08_423993	45	3	mutagenesis	mutagenesis	NN
10_1101-2021_01_08_423993	45	4	was	be	VBD
10_1101-2021_01_08_423993	45	5	carried	carry	VBN
10_1101-2021_01_08_423993	45	6	out	out	RP
10_1101-2021_01_08_423993	45	7	using	use	VBG
10_1101-2021_01_08_423993	45	8	an	an	DT
10_1101-2021_01_08_423993	45	9	inverse	inverse	NN
10_1101-2021_01_08_423993	45	10	PCR	PCR	NNP
10_1101-2021_01_08_423993	45	11	experiment	experiment	NN
10_1101-2021_01_08_423993	45	12	whereby	whereby	WRB
10_1101-2021_01_08_423993	45	13	an	an	DT
10_1101-2021_01_08_423993	45	14	entire	entire	JJ
10_1101-2021_01_08_423993	45	15	plasmid	plasmid	NN
10_1101-2021_01_08_423993	45	16	is	be	VBZ
10_1101-2021_01_08_423993	45	17	amplified	amplify	VBN
10_1101-2021_01_08_423993	45	18	using	use	VBG
10_1101-2021_01_08_423993	45	19	complementary	complementary	JJ
10_1101-2021_01_08_423993	45	20	mutagenic	mutagenic	JJ
10_1101-2021_01_08_423993	45	21	primers	primer	NNS
10_1101-2021_01_08_423993	45	22	(	(	-LRB-
10_1101-2021_01_08_423993	45	23	oligonucleotides	oligonucleotide	NNS
10_1101-2021_01_08_423993	45	24	)	)	-RRB-
10_1101-2021_01_08_423993	45	25	with	with	IN
10_1101-2021_01_08_423993	45	26	minimal	minimal	JJ
10_1101-2021_01_08_423993	45	27	cloning	clone	VBG
10_1101-2021_01_08_423993	45	28	steps	step	NNS
10_1101-2021_01_08_423993	45	29	[	[	-LRB-
10_1101-2021_01_08_423993	45	30	36	36	CD
10_1101-2021_01_08_423993	45	31	]	]	-RRB-
10_1101-2021_01_08_423993	45	32	.	.	.
10_1101-2021_01_08_423993	46	1	Using	use	VBG
10_1101-2021_01_08_423993	46	2	the	the	DT
10_1101-2021_01_08_423993	46	3	high	high	JJ
10_1101-2021_01_08_423993	46	4	-	-	HYPH
10_1101-2021_01_08_423993	46	5	fidelity	fidelity	NN
10_1101-2021_01_08_423993	46	6	and	and	CC
10_1101-2021_01_08_423993	46	7	high-	high-	JJ
10_1101-2021_01_08_423993	46	8	processivity	processivity	NN
10_1101-2021_01_08_423993	46	9	enzyme	enzyme	NNS
10_1101-2021_01_08_423993	46	10	Herculase	Herculase	NNP
10_1101-2021_01_08_423993	46	11	II	II	NNP
10_1101-2021_01_08_423993	46	12	Fusion	Fusion	NNP
10_1101-2021_01_08_423993	46	13	DNA	DNA	NNP
10_1101-2021_01_08_423993	46	14	Polymerase	Polymerase	NNP
10_1101-2021_01_08_423993	46	15	(	(	-LRB-
10_1101-2021_01_08_423993	46	16	Agilent	Agilent	NNP
10_1101-2021_01_08_423993	46	17	)	)	-RRB-
10_1101-2021_01_08_423993	46	18	,	,	,
10_1101-2021_01_08_423993	46	19	a	a	DT
10_1101-2021_01_08_423993	46	20	PCR	PCR	NNP
10_1101-2021_01_08_423993	46	21	was	be	VBD
10_1101-2021_01_08_423993	46	22	performed	perform	VBN
10_1101-2021_01_08_423993	46	23	to	to	TO
10_1101-2021_01_08_423993	46	24	amplify	amplify	VB
10_1101-2021_01_08_423993	46	25	a	a	DT
10_1101-2021_01_08_423993	46	26	whole	whole	JJ
10_1101-2021_01_08_423993	46	27	plasmid	plasmid	NN
10_1101-2021_01_08_423993	46	28	.	.	.
10_1101-2021_01_08_423993	47	1	The	the	DT
10_1101-2021_01_08_423993	47	2	PCR	PCR	NNP
10_1101-2021_01_08_423993	47	3	product	product	NN
10_1101-2021_01_08_423993	47	4	was	be	VBD
10_1101-2021_01_08_423993	47	5	then	then	RB
10_1101-2021_01_08_423993	47	6	added	add	VBN
10_1101-2021_01_08_423993	47	7	to	to	IN
10_1101-2021_01_08_423993	47	8	a	a	DT
10_1101-2021_01_08_423993	47	9	KLD	KLD	NNP
10_1101-2021_01_08_423993	47	10	enzyme	enzyme	NNS
10_1101-2021_01_08_423993	47	11	mix	mix	VBP
10_1101-2021_01_08_423993	47	12	(	(	-LRB-
10_1101-2021_01_08_423993	47	13	NEB	NEB	NNP
10_1101-2021_01_08_423993	47	14	)	)	-RRB-
10_1101-2021_01_08_423993	47	15	reaction	reaction	NN
10_1101-2021_01_08_423993	47	16	and	and	CC
10_1101-2021_01_08_423993	47	17	was	be	VBD
10_1101-2021_01_08_423993	47	18	incubated	incubate	VBN
10_1101-2021_01_08_423993	47	19	at	at	IN
10_1101-2021_01_08_423993	47	20	room	room	NN
10_1101-2021_01_08_423993	47	21	temperature	temperature	NN
10_1101-2021_01_08_423993	47	22	for	for	IN
10_1101-2021_01_08_423993	47	23	1	1	CD
10_1101-2021_01_08_423993	47	24	hour	hour	NN
10_1101-2021_01_08_423993	47	25	,	,	,
10_1101-2021_01_08_423993	47	26	prior	prior	RB
10_1101-2021_01_08_423993	47	27	to	to	IN
10_1101-2021_01_08_423993	47	28	transformation	transformation	NN
10_1101-2021_01_08_423993	47	29	into	into	IN
10_1101-2021_01_08_423993	47	30	Escherichia	Escherichia	NNP
10_1101-2021_01_08_423993	47	31	coli	coli	NNS
10_1101-2021_01_08_423993	47	32	cells	cell	NNS
10_1101-2021_01_08_423993	47	33	.	.	.
10_1101-2021_01_08_423993	48	1	Expression	expression	NN
10_1101-2021_01_08_423993	48	2	and	and	CC
10_1101-2021_01_08_423993	48	3	purification	purification	NN
10_1101-2021_01_08_423993	48	4	of	of	IN
10_1101-2021_01_08_423993	48	5	WT	WT	NNP
10_1101-2021_01_08_423993	48	6	and	and	CC
10_1101-2021_01_08_423993	48	7	mutant	mutant	NN
10_1101-2021_01_08_423993	48	8	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	48	9	with	with	IN
10_1101-2021_01_08_423993	48	10	IMAC	IMAC	NNP
10_1101-2021_01_08_423993	48	11	(	(	-LRB-
10_1101-2021_01_08_423993	48	12	aa	aa	NNP
10_1101-2021_01_08_423993	48	13	1	1	CD
10_1101-2021_01_08_423993	48	14	-	-	SYM
10_1101-2021_01_08_423993	48	15	362	362	CD
10_1101-2021_01_08_423993	48	16	)	)	-RRB-
10_1101-2021_01_08_423993	48	17	Baculovirus	Baculovirus	NNP
10_1101-2021_01_08_423993	48	18	generation	generation	NN
10_1101-2021_01_08_423993	48	19	was	be	VBD
10_1101-2021_01_08_423993	48	20	performed	perform	VBN
10_1101-2021_01_08_423993	48	21	as	as	IN
10_1101-2021_01_08_423993	48	22	previously	previously	RB
10_1101-2021_01_08_423993	48	23	described	describe	VBN
10_1101-2021_01_08_423993	48	24	[	[	-LRB-
10_1101-2021_01_08_423993	48	25	3	3	CD
10_1101-2021_01_08_423993	48	26	]	]	-RRB-
10_1101-2021_01_08_423993	48	27	.	.	.
10_1101-2021_01_08_423993	49	1	Recombinant	recombinant	JJ
10_1101-2021_01_08_423993	49	2	proteins	protein	NNS
10_1101-2021_01_08_423993	49	3	were	be	VBD
10_1101-2021_01_08_423993	49	4	produced	produce	VBN
10_1101-2021_01_08_423993	49	5	in	in	IN
10_1101-2021_01_08_423993	49	6	Sf9	sf9	JJ
10_1101-2021_01_08_423993	49	7	cell	cell	NN
10_1101-2021_01_08_423993	49	8	at	at	IN
10_1101-2021_01_08_423993	49	9	2	2	CD
10_1101-2021_01_08_423993	49	10	x	x	SYM
10_1101-2021_01_08_423993	49	11	106	106	CD
10_1101-2021_01_08_423993	49	12	cells/	cells/	NN
10_1101-2021_01_08_423993	49	13	mL	ml	NN
10_1101-2021_01_08_423993	49	14	infected	infect	VBN
10_1101-2021_01_08_423993	49	15	with	with	IN
10_1101-2021_01_08_423993	49	16	1.5	1.5	CD
10_1101-2021_01_08_423993	49	17	mL	ml	NN
10_1101-2021_01_08_423993	49	18	of	of	IN
10_1101-2021_01_08_423993	49	19	P2	P2	NNP
10_1101-2021_01_08_423993	49	20	virus	virus	NN
10_1101-2021_01_08_423993	49	21	for	for	IN
10_1101-2021_01_08_423993	49	22	WT	WT	NNP
10_1101-2021_01_08_423993	49	23	and	and	CC
10_1101-2021_01_08_423993	49	24	3	3	CD
10_1101-2021_01_08_423993	49	25	mL	mL	NNP
10_1101-2021_01_08_423993	49	26	of	of	IN
10_1101-2021_01_08_423993	49	27	P2	P2	NNP
10_1101-2021_01_08_423993	49	28	virus	virus	NN
10_1101-2021_01_08_423993	49	29	for	for	IN
10_1101-2021_01_08_423993	49	30	mutants	mutant	NNS
10_1101-2021_01_08_423993	49	31	respectively	respectively	RB
10_1101-2021_01_08_423993	49	32	.	.	.
10_1101-2021_01_08_423993	50	1	Infected	infected	JJ
10_1101-2021_01_08_423993	50	2	Sf9	sf9	JJ
10_1101-2021_01_08_423993	50	3	cells	cell	NNS
10_1101-2021_01_08_423993	50	4	were	be	VBD
10_1101-2021_01_08_423993	50	5	harvested	harvest	VBN
10_1101-2021_01_08_423993	50	6	70	70	CD
10_1101-2021_01_08_423993	50	7	h	h	NN
10_1101-2021_01_08_423993	50	8	after	after	IN
10_1101-2021_01_08_423993	50	9	infection	infection	NN
10_1101-2021_01_08_423993	50	10	by	by	IN
10_1101-2021_01_08_423993	50	11	centrifugation	centrifugation	NN
10_1101-2021_01_08_423993	50	12	(	(	-LRB-
10_1101-2021_01_08_423993	50	13	900	900	CD
10_1101-2021_01_08_423993	50	14	x	x	SYM
10_1101-2021_01_08_423993	50	15	g	g	NN
10_1101-2021_01_08_423993	50	16	,	,	,
10_1101-2021_01_08_423993	50	17	20	20	CD
10_1101-2021_01_08_423993	50	18	min	min	NN
10_1101-2021_01_08_423993	50	19	)	)	-RRB-
10_1101-2021_01_08_423993	50	20	.	.	.
10_1101-2021_01_08_423993	51	1	The	the	DT
10_1101-2021_01_08_423993	51	2	cell	cell	NN
10_1101-2021_01_08_423993	51	3	pellet	pellet	NN
10_1101-2021_01_08_423993	51	4	was	be	VBD
10_1101-2021_01_08_423993	51	5	resuspended	resuspend	VBN
10_1101-2021_01_08_423993	51	6	in	in	IN
10_1101-2021_01_08_423993	51	7	30	30	CD
10_1101-2021_01_08_423993	51	8	mL/	mL/	NNS
10_1101-2021_01_08_423993	51	9	L	l	NN
10_1101-2021_01_08_423993	51	10	.CC	.CC	:
10_1101-2021_01_08_423993	51	11	-	-	:
10_1101-2021_01_08_423993	51	12	BY	by	IN
10_1101-2021_01_08_423993	51	13	4.0	4.0	CD
10_1101-2021_01_08_423993	51	14	International	international	JJ
10_1101-2021_01_08_423993	51	15	licensemade	licensemade	NN
10_1101-2021_01_08_423993	51	16	available	available	JJ
10_1101-2021_01_08_423993	51	17	under	under	IN
10_1101-2021_01_08_423993	51	18	a	a	DT
10_1101-2021_01_08_423993	51	19	(	(	-LRB-
10_1101-2021_01_08_423993	51	20	which	which	WDT
10_1101-2021_01_08_423993	51	21	was	be	VBD
10_1101-2021_01_08_423993	51	22	not	not	RB
10_1101-2021_01_08_423993	51	23	certified	certify	VBN
10_1101-2021_01_08_423993	51	24	by	by	IN
10_1101-2021_01_08_423993	51	25	peer	peer	NN
10_1101-2021_01_08_423993	51	26	review	review	NN
10_1101-2021_01_08_423993	51	27	)	)	-RRB-
10_1101-2021_01_08_423993	51	28	is	be	VBZ
10_1101-2021_01_08_423993	51	29	the	the	DT
10_1101-2021_01_08_423993	51	30	author	author	NN
10_1101-2021_01_08_423993	51	31	/	/	SYM
10_1101-2021_01_08_423993	51	32	funder	funder	NN
10_1101-2021_01_08_423993	51	33	,	,	,
10_1101-2021_01_08_423993	51	34	who	who	WP
10_1101-2021_01_08_423993	51	35	has	have	VBZ
10_1101-2021_01_08_423993	51	36	granted	grant	VBN
10_1101-2021_01_08_423993	51	37	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	51	38	a	a	DT
10_1101-2021_01_08_423993	51	39	license	license	NN
10_1101-2021_01_08_423993	51	40	to	to	TO
10_1101-2021_01_08_423993	51	41	display	display	VB
10_1101-2021_01_08_423993	51	42	the	the	DT
10_1101-2021_01_08_423993	51	43	preprint	preprint	NN
10_1101-2021_01_08_423993	51	44	in	in	IN
10_1101-2021_01_08_423993	51	45	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	51	46	.	.	.
10_1101-2021_01_08_423993	52	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	52	2	is	be	VBZ
10_1101-2021_01_08_423993	52	3	The	the	DT
10_1101-2021_01_08_423993	52	4	copyright	copyright	NN
10_1101-2021_01_08_423993	52	5	holder	holder	NN
10_1101-2021_01_08_423993	52	6	for	for	IN
10_1101-2021_01_08_423993	52	7	this	this	DT
10_1101-2021_01_08_423993	52	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	52	9	version	version	NN
10_1101-2021_01_08_423993	52	10	posted	post	VBD
10_1101-2021_01_08_423993	52	11	January	January	NNP
10_1101-2021_01_08_423993	52	12	8	8	CD
10_1101-2021_01_08_423993	52	13	,	,	,
10_1101-2021_01_08_423993	52	14	2021	2021	CD
10_1101-2021_01_08_423993	52	15	.	.	.
10_1101-2021_01_08_423993	52	16	;	;	:
10_1101-2021_01_08_423993	52	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	52	18	:	:	:
10_1101-2021_01_08_423993	52	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	52	20	preprint	preprint	NN
10_1101-2021_01_08_423993	52	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	CD
10_1101-2021_01_08_423993	52	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	52	23	lysis	lysis	NN
10_1101-2021_01_08_423993	52	24	buffer	buffer	NN
10_1101-2021_01_08_423993	52	25	(	(	-LRB-
10_1101-2021_01_08_423993	52	26	50	50	CD
10_1101-2021_01_08_423993	52	27	mM	mM	NNP
10_1101-2021_01_08_423993	52	28	HEPES	hepe	NNS
10_1101-2021_01_08_423993	52	29	pH	pH	NNP
10_1101-2021_01_08_423993	52	30	7.5	7.5	CD
10_1101-2021_01_08_423993	52	31	,	,	,
10_1101-2021_01_08_423993	52	32	500	500	CD
10_1101-2021_01_08_423993	52	33	mM	mM	NNP
10_1101-2021_01_08_423993	52	34	NaCl	NaCl	NNP
10_1101-2021_01_08_423993	52	35	,	,	,
10_1101-2021_01_08_423993	52	36	10	10	CD
10_1101-2021_01_08_423993	52	37	mM	mm	NN
10_1101-2021_01_08_423993	52	38	imidazole	imidazole	NN
10_1101-2021_01_08_423993	52	39	,	,	,
10_1101-2021_01_08_423993	52	40	5	5	CD
10_1101-2021_01_08_423993	52	41	%	%	NN
10_1101-2021_01_08_423993	52	42	(	(	-LRB-
10_1101-2021_01_08_423993	52	43	v	v	NN
10_1101-2021_01_08_423993	52	44	/	/	SYM
10_1101-2021_01_08_423993	52	45	v	v	NN
10_1101-2021_01_08_423993	52	46	)	)	-RRB-
10_1101-2021_01_08_423993	52	47	glycerol	glycerol	NN
10_1101-2021_01_08_423993	52	48	and	and	CC
10_1101-2021_01_08_423993	52	49	1	1	CD
10_1101-2021_01_08_423993	52	50	mM	mM	NNP
10_1101-2021_01_08_423993	52	51	TCEP	TCEP	NNP
10_1101-2021_01_08_423993	52	52	)	)	-RRB-
10_1101-2021_01_08_423993	52	53	,	,	,
10_1101-2021_01_08_423993	52	54	snap	snap	VBP
10_1101-2021_01_08_423993	52	55	frozen	frozen	JJ
10_1101-2021_01_08_423993	52	56	in	in	IN
10_1101-2021_01_08_423993	52	57	liquid	liquid	JJ
10_1101-2021_01_08_423993	52	58	nitrogen	nitrogen	NN
10_1101-2021_01_08_423993	52	59	,	,	,
10_1101-2021_01_08_423993	52	60	then	then	RB
10_1101-2021_01_08_423993	52	61	stored	store	VBD
10_1101-2021_01_08_423993	52	62	at	at	IN
10_1101-2021_01_08_423993	52	63	−80	−80	NNP
10_1101-2021_01_08_423993	52	64	°	°	,
10_1101-2021_01_08_423993	52	65	C	C	NNP
10_1101-2021_01_08_423993	52	66	for	for	IN
10_1101-2021_01_08_423993	52	67	later	later	JJ
10_1101-2021_01_08_423993	52	68	use	use	NN
10_1101-2021_01_08_423993	52	69	.	.	.
10_1101-2021_01_08_423993	53	1	Thawed	thaw	VBN
10_1101-2021_01_08_423993	53	2	cell	cell	NN
10_1101-2021_01_08_423993	53	3	aliquots	aliquot	NNS
10_1101-2021_01_08_423993	53	4	were	be	VBD
10_1101-2021_01_08_423993	53	5	lysed	lyse	VBN
10_1101-2021_01_08_423993	53	6	by	by	IN
10_1101-2021_01_08_423993	53	7	sonication	sonication	NN
10_1101-2021_01_08_423993	53	8	.	.	.
10_1101-2021_01_08_423993	54	1	The	the	DT
10_1101-2021_01_08_423993	54	2	lysates	lysate	NNS
10_1101-2021_01_08_423993	54	3	were	be	VBD
10_1101-2021_01_08_423993	54	4	clarified	clarify	VBN
10_1101-2021_01_08_423993	54	5	by	by	IN
10_1101-2021_01_08_423993	54	6	centrifugation	centrifugation	NN
10_1101-2021_01_08_423993	54	7	(	(	-LRB-
10_1101-2021_01_08_423993	54	8	40,000	40,000	CD
10_1101-2021_01_08_423993	54	9	g	g	NNP
10_1101-2021_01_08_423993	54	10	,	,	,
10_1101-2021_01_08_423993	54	11	30	30	CD
10_1101-2021_01_08_423993	54	12	min	min	NN
10_1101-2021_01_08_423993	54	13	)	)	-RRB-
10_1101-2021_01_08_423993	54	14	,	,	,
10_1101-2021_01_08_423993	54	15	then	then	RB
10_1101-2021_01_08_423993	54	16	the	the	DT
10_1101-2021_01_08_423993	54	17	supernatant	supernatant	NN
10_1101-2021_01_08_423993	54	18	was	be	VBD
10_1101-2021_01_08_423993	54	19	passed	pass	VBN
10_1101-2021_01_08_423993	54	20	through	through	IN
10_1101-2021_01_08_423993	54	21	a	a	DT
10_1101-2021_01_08_423993	54	22	0.80	0.80	CD
10_1101-2021_01_08_423993	54	23	μm	μm	NN
10_1101-2021_01_08_423993	54	24	filter	filter	NN
10_1101-2021_01_08_423993	54	25	(	(	-LRB-
10_1101-2021_01_08_423993	54	26	Millipore	Millipore	NNP
10_1101-2021_01_08_423993	54	27	)	)	-RRB-
10_1101-2021_01_08_423993	54	28	and	and	CC
10_1101-2021_01_08_423993	54	29	loaded	load	VBD
10_1101-2021_01_08_423993	54	30	onto	onto	IN
10_1101-2021_01_08_423993	54	31	an	an	DT
10_1101-2021_01_08_423993	54	32	equilibrated	equilibrated	JJ
10_1101-2021_01_08_423993	54	33	(	(	-LRB-
10_1101-2021_01_08_423993	54	34	lysis	lysis	NN
10_1101-2021_01_08_423993	54	35	buffer	buffer	NN
10_1101-2021_01_08_423993	54	36	)	)	-RRB-
10_1101-2021_01_08_423993	54	37	immobilised	immobilise	VBD
10_1101-2021_01_08_423993	54	38	metal	metal	NN
10_1101-2021_01_08_423993	54	39	affinity	affinity	NN
10_1101-2021_01_08_423993	54	40	chromatography	chromatography	NN
10_1101-2021_01_08_423993	54	41	column	column	NN
10_1101-2021_01_08_423993	54	42	(	(	-LRB-
10_1101-2021_01_08_423993	54	43	IMAC	IMAC	NNP
10_1101-2021_01_08_423993	54	44	)	)	-RRB-
10_1101-2021_01_08_423993	54	45	(	(	-LRB-
10_1101-2021_01_08_423993	54	46	Ni	ni	RB
10_1101-2021_01_08_423993	54	47	-	-	HYPH
10_1101-2021_01_08_423993	54	48	NTA	NTA	NNP
10_1101-2021_01_08_423993	54	49	Superflow	Superflow	NNP
10_1101-2021_01_08_423993	54	50	Cartridge	Cartridge	NNP
10_1101-2021_01_08_423993	54	51	,	,	,
10_1101-2021_01_08_423993	54	52	Qiagen	Qiagen	NNP
10_1101-2021_01_08_423993	54	53	)	)	-RRB-
10_1101-2021_01_08_423993	54	54	.	.	.
10_1101-2021_01_08_423993	55	1	The	the	DT
10_1101-2021_01_08_423993	55	2	immobilised	immobilised	JJ
10_1101-2021_01_08_423993	55	3	protein	protein	NN
10_1101-2021_01_08_423993	55	4	was	be	VBD
10_1101-2021_01_08_423993	55	5	washed	wash	VBN
10_1101-2021_01_08_423993	55	6	with	with	IN
10_1101-2021_01_08_423993	55	7	lysis	lysis	NN
10_1101-2021_01_08_423993	55	8	buffer	buffer	NN
10_1101-2021_01_08_423993	55	9	,	,	,
10_1101-2021_01_08_423993	55	10	then	then	RB
10_1101-2021_01_08_423993	55	11	eluted	elute	VBD
10_1101-2021_01_08_423993	55	12	using	use	VBG
10_1101-2021_01_08_423993	55	13	a	a	DT
10_1101-2021_01_08_423993	55	14	linear	linear	JJ
10_1101-2021_01_08_423993	55	15	gradient	gradient	NN
10_1101-2021_01_08_423993	55	16	of	of	IN
10_1101-2021_01_08_423993	55	17	elution	elution	NN
10_1101-2021_01_08_423993	55	18	buffer	buffer	NNP
10_1101-2021_01_08_423993	55	19	(	(	-LRB-
10_1101-2021_01_08_423993	55	20	50	50	CD
10_1101-2021_01_08_423993	55	21	mM	mM	NNP
10_1101-2021_01_08_423993	55	22	HEPES	hepe	NNS
10_1101-2021_01_08_423993	55	23	pH	pH	NNP
10_1101-2021_01_08_423993	55	24	7.5	7.5	CD
10_1101-2021_01_08_423993	55	25	,	,	,
10_1101-2021_01_08_423993	55	26	500	500	CD
10_1101-2021_01_08_423993	55	27	mM	mM	NNP
10_1101-2021_01_08_423993	55	28	NaCl	NaCl	NNP
10_1101-2021_01_08_423993	55	29	,	,	,
10_1101-2021_01_08_423993	55	30	300	300	CD
10_1101-2021_01_08_423993	55	31	mM	mM	NNP
10_1101-2021_01_08_423993	55	32	imidazole	imidazole	NN
10_1101-2021_01_08_423993	55	33	,	,	,
10_1101-2021_01_08_423993	55	34	5	5	CD
10_1101-2021_01_08_423993	55	35	%	%	NN
10_1101-2021_01_08_423993	55	36	v	v	NN
10_1101-2021_01_08_423993	55	37	/	/	SYM
10_1101-2021_01_08_423993	55	38	v	v	NN
10_1101-2021_01_08_423993	55	39	glycerol	glycerol	NN
10_1101-2021_01_08_423993	55	40	,	,	,
10_1101-2021_01_08_423993	55	41	and	and	CC
10_1101-2021_01_08_423993	55	42	1	1	CD
10_1101-2021_01_08_423993	55	43	mM	mM	NNP
10_1101-2021_01_08_423993	55	44	TCEP	tcep	NN
10_1101-2021_01_08_423993	55	45	)	)	-RRB-
10_1101-2021_01_08_423993	55	46	.	.	.
10_1101-2021_01_08_423993	56	1	The	the	DT
10_1101-2021_01_08_423993	56	2	protein	protein	NN
10_1101-2021_01_08_423993	56	3	containing	contain	VBG
10_1101-2021_01_08_423993	56	4	fractions	fraction	NNS
10_1101-2021_01_08_423993	56	5	were	be	VBD
10_1101-2021_01_08_423993	56	6	pooled	pool	VBN
10_1101-2021_01_08_423993	56	7	and	and	CC
10_1101-2021_01_08_423993	56	8	passed	pass	VBN
10_1101-2021_01_08_423993	56	9	through	through	IN
10_1101-2021_01_08_423993	56	10	an	an	DT
10_1101-2021_01_08_423993	56	11	ion	ion	NN
10_1101-2021_01_08_423993	56	12	exchange	exchange	NN
10_1101-2021_01_08_423993	56	13	column	column	NN
10_1101-2021_01_08_423993	56	14	(	(	-LRB-
10_1101-2021_01_08_423993	56	15	HiTrap	HiTrap	NNP
10_1101-2021_01_08_423993	56	16	®	®	NNP
10_1101-2021_01_08_423993	56	17	SP	SP	NNP
10_1101-2021_01_08_423993	56	18	FF	FF	NNP
10_1101-2021_01_08_423993	56	19	GE	GE	NNP
10_1101-2021_01_08_423993	56	20	Healthcare	Healthcare	NNP
10_1101-2021_01_08_423993	56	21	Life	Life	NNP
10_1101-2021_01_08_423993	56	22	Sciences	Sciences	NNPS
10_1101-2021_01_08_423993	56	23	)	)	-RRB-
10_1101-2021_01_08_423993	56	24	pre	pre	VB
10_1101-2021_01_08_423993	56	25	-	-	VBN
10_1101-2021_01_08_423993	56	26	equilibrated	equilibrated	JJ
10_1101-2021_01_08_423993	56	27	in	in	IN
10_1101-2021_01_08_423993	56	28	the	the	DT
10_1101-2021_01_08_423993	56	29	SP	SP	NNP
10_1101-2021_01_08_423993	56	30	buffer	buffer	NN
10_1101-2021_01_08_423993	56	31	A	a	NN
10_1101-2021_01_08_423993	56	32	(	(	-LRB-
10_1101-2021_01_08_423993	56	33	25	25	CD
10_1101-2021_01_08_423993	56	34	mM	mM	NNP
10_1101-2021_01_08_423993	56	35	HEPES	hepe	NNS
10_1101-2021_01_08_423993	56	36	pH	pH	NNP
10_1101-2021_01_08_423993	56	37	7.5	7.5	CD
10_1101-2021_01_08_423993	56	38	,	,	,
10_1101-2021_01_08_423993	56	39	300	300	CD
10_1101-2021_01_08_423993	56	40	mM	mM	NNP
10_1101-2021_01_08_423993	56	41	NaCl	NaCl	NNP
10_1101-2021_01_08_423993	56	42	,	,	,
10_1101-2021_01_08_423993	56	43	5	5	CD
10_1101-2021_01_08_423993	56	44	%	%	NN
10_1101-2021_01_08_423993	56	45	(	(	-LRB-
10_1101-2021_01_08_423993	56	46	v	v	NN
10_1101-2021_01_08_423993	56	47	/	/	SYM
10_1101-2021_01_08_423993	56	48	v	v	NN
10_1101-2021_01_08_423993	56	49	)	)	-RRB-
10_1101-2021_01_08_423993	56	50	glycerol	glycerol	NN
10_1101-2021_01_08_423993	56	51	and	and	CC
10_1101-2021_01_08_423993	56	52	1	1	CD
10_1101-2021_01_08_423993	56	53	mM	mM	NNP
10_1101-2021_01_08_423993	56	54	TCEP	tcep	NN
10_1101-2021_01_08_423993	56	55	)	)	-RRB-
10_1101-2021_01_08_423993	56	56	.	.	.
10_1101-2021_01_08_423993	57	1	The	the	DT
10_1101-2021_01_08_423993	57	2	protein	protein	NN
10_1101-2021_01_08_423993	57	3	was	be	VBD
10_1101-2021_01_08_423993	57	4	eluted	elute	VBN
10_1101-2021_01_08_423993	57	5	using	use	VBG
10_1101-2021_01_08_423993	57	6	a	a	DT
10_1101-2021_01_08_423993	57	7	linear	linear	JJ
10_1101-2021_01_08_423993	57	8	gradient	gradient	NN
10_1101-2021_01_08_423993	57	9	of	of	IN
10_1101-2021_01_08_423993	57	10	SP	SP	NNP
10_1101-2021_01_08_423993	57	11	buffer	buffer	NN
10_1101-2021_01_08_423993	57	12	B	B	NNP
10_1101-2021_01_08_423993	57	13	(	(	-LRB-
10_1101-2021_01_08_423993	57	14	SP	SP	NNP
10_1101-2021_01_08_423993	57	15	buffer	buffer	NN
10_1101-2021_01_08_423993	57	16	A	A	NNP
10_1101-2021_01_08_423993	57	17	with	with	IN
10_1101-2021_01_08_423993	57	18	1	1	CD
10_1101-2021_01_08_423993	57	19	M	M	NNP
10_1101-2021_01_08_423993	57	20	NaCl	NaCl	NNP
10_1101-2021_01_08_423993	57	21	)	)	-RRB-
10_1101-2021_01_08_423993	57	22	,	,	,
10_1101-2021_01_08_423993	57	23	and	and	CC
10_1101-2021_01_08_423993	57	24	fractions	fraction	NNS
10_1101-2021_01_08_423993	57	25	containing	contain	VBG
10_1101-2021_01_08_423993	57	26	the	the	DT
10_1101-2021_01_08_423993	57	27	tag	tag	NN
10_1101-2021_01_08_423993	57	28	-	-	HYPH
10_1101-2021_01_08_423993	57	29	free	free	JJ
10_1101-2021_01_08_423993	57	30	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	57	31	were	be	VBD
10_1101-2021_01_08_423993	57	32	identified	identify	VBN
10_1101-2021_01_08_423993	57	33	by	by	IN
10_1101-2021_01_08_423993	57	34	electrophoresis	electrophoresis	NN
10_1101-2021_01_08_423993	57	35	.	.	.
10_1101-2021_01_08_423993	58	1	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	58	2	containing	contain	VBG
10_1101-2021_01_08_423993	58	3	fractions	fraction	NNS
10_1101-2021_01_08_423993	58	4	were	be	VBD
10_1101-2021_01_08_423993	58	5	pooled	pool	VBN
10_1101-2021_01_08_423993	58	6	and	and	CC
10_1101-2021_01_08_423993	58	7	dialysed	dialyse	VBN
10_1101-2021_01_08_423993	58	8	overnight	overnight	RB
10_1101-2021_01_08_423993	58	9	at	at	IN
10_1101-2021_01_08_423993	58	10	4	4	CD
10_1101-2021_01_08_423993	58	11	°	°	NNS
10_1101-2021_01_08_423993	58	12	C	C	NNP
10_1101-2021_01_08_423993	58	13	in	in	IN
10_1101-2021_01_08_423993	58	14	SP	SP	NNP
10_1101-2021_01_08_423993	58	15	buffer	buffer	NN
10_1101-2021_01_08_423993	58	16	A	A	NNP
10_1101-2021_01_08_423993	58	17	and	and	CC
10_1101-2021_01_08_423993	58	18	supplemented	supplement	VBN
10_1101-2021_01_08_423993	58	19	with	with	IN
10_1101-2021_01_08_423993	58	20	recombinant	recombinant	JJ
10_1101-2021_01_08_423993	58	21	tobacco	tobacco	NN
10_1101-2021_01_08_423993	58	22	etch	etch	NN
10_1101-2021_01_08_423993	58	23	virus	virus	NN
10_1101-2021_01_08_423993	58	24	(	(	-LRB-
10_1101-2021_01_08_423993	58	25	TEV	TEV	NNP
10_1101-2021_01_08_423993	58	26	)	)	-RRB-
10_1101-2021_01_08_423993	58	27	protease	protease	NN
10_1101-2021_01_08_423993	58	28	for	for	IN
10_1101-2021_01_08_423993	58	29	cleavage	cleavage	NN
10_1101-2021_01_08_423993	58	30	of	of	IN
10_1101-2021_01_08_423993	58	31	the	the	DT
10_1101-2021_01_08_423993	58	32	6His-	6His-	NNP
10_1101-2021_01_08_423993	58	33	ZB	ZB	NNP
10_1101-2021_01_08_423993	58	34	tag	tag	NN
10_1101-2021_01_08_423993	58	35	.	.	.
10_1101-2021_01_08_423993	59	1	The	the	DT
10_1101-2021_01_08_423993	59	2	protein	protein	NN
10_1101-2021_01_08_423993	59	3	was	be	VBD
10_1101-2021_01_08_423993	59	4	subsequently	subsequently	RB
10_1101-2021_01_08_423993	59	5	loaded	load	VBN
10_1101-2021_01_08_423993	59	6	into	into	IN
10_1101-2021_01_08_423993	59	7	an	an	DT
10_1101-2021_01_08_423993	59	8	ion	ion	NN
10_1101-2021_01_08_423993	59	9	exchange	exchange	NN
10_1101-2021_01_08_423993	59	10	column	column	NN
10_1101-2021_01_08_423993	59	11	(	(	-LRB-
10_1101-2021_01_08_423993	59	12	HiTrap	HiTrap	NNP
10_1101-2021_01_08_423993	59	13	®	®	NNP
10_1101-2021_01_08_423993	59	14	SP	SP	NNP
10_1101-2021_01_08_423993	59	15	FF	FF	NNP
10_1101-2021_01_08_423993	59	16	GE	GE	NNP
10_1101-2021_01_08_423993	59	17	Healthcare	Healthcare	NNP
10_1101-2021_01_08_423993	59	18	Life	Life	NNP
10_1101-2021_01_08_423993	59	19	Sciences	Sciences	NNPS
10_1101-2021_01_08_423993	59	20	)	)	-RRB-
10_1101-2021_01_08_423993	59	21	,	,	,
10_1101-2021_01_08_423993	59	22	pre	pre	VBN
10_1101-2021_01_08_423993	59	23	-	-	VBN
10_1101-2021_01_08_423993	59	24	equilibrated	equilibrated	JJ
10_1101-2021_01_08_423993	59	25	in	in	IN
10_1101-2021_01_08_423993	59	26	the	the	DT
10_1101-2021_01_08_423993	59	27	SP	SP	NNP
10_1101-2021_01_08_423993	59	28	buffer	buffer	NN
10_1101-2021_01_08_423993	59	29	A	A	NNP
10_1101-2021_01_08_423993	59	30	to	to	TO
10_1101-2021_01_08_423993	59	31	remove	remove	VB
10_1101-2021_01_08_423993	59	32	6His	6his	CD
10_1101-2021_01_08_423993	59	33	-	-	HYPH
10_1101-2021_01_08_423993	59	34	ZB	zb	NN
10_1101-2021_01_08_423993	59	35	tag	tag	NN
10_1101-2021_01_08_423993	59	36	and	and	CC
10_1101-2021_01_08_423993	59	37	uncleaved	uncleaved	JJ
10_1101-2021_01_08_423993	59	38	protein	protein	NN
10_1101-2021_01_08_423993	59	39	.	.	.
10_1101-2021_01_08_423993	60	1	The	the	DT
10_1101-2021_01_08_423993	60	2	protein	protein	NN
10_1101-2021_01_08_423993	60	3	was	be	VBD
10_1101-2021_01_08_423993	60	4	eluted	elute	VBN
10_1101-2021_01_08_423993	60	5	using	use	VBG
10_1101-2021_01_08_423993	60	6	a	a	DT
10_1101-2021_01_08_423993	60	7	linear	linear	JJ
10_1101-2021_01_08_423993	60	8	gradient	gradient	NN
10_1101-2021_01_08_423993	60	9	of	of	IN
10_1101-2021_01_08_423993	60	10	SP	SP	NNP
10_1101-2021_01_08_423993	60	11	buffer	buffer	NN
10_1101-2021_01_08_423993	60	12	B	B	NNP
10_1101-2021_01_08_423993	60	13	,	,	,
10_1101-2021_01_08_423993	60	14	and	and	CC
10_1101-2021_01_08_423993	60	15	fractions	fraction	NNS
10_1101-2021_01_08_423993	60	16	containing	contain	VBG
10_1101-2021_01_08_423993	60	17	the	the	DT
10_1101-2021_01_08_423993	60	18	tag	tag	NN
10_1101-2021_01_08_423993	60	19	-	-	HYPH
10_1101-2021_01_08_423993	60	20	free	free	JJ
10_1101-2021_01_08_423993	60	21	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	60	22	were	be	VBD
10_1101-2021_01_08_423993	60	23	identified	identify	VBN
10_1101-2021_01_08_423993	60	24	by	by	IN
10_1101-2021_01_08_423993	60	25	electrophoresis	electrophoresis	NN
10_1101-2021_01_08_423993	60	26	.	.	.
10_1101-2021_01_08_423993	61	1	Artemis-	Artemis-	NNP
10_1101-2021_01_08_423993	61	2	containing	contain	VBG
10_1101-2021_01_08_423993	61	3	fractions	fraction	NNS
10_1101-2021_01_08_423993	61	4	from	from	IN
10_1101-2021_01_08_423993	61	5	the	the	DT
10_1101-2021_01_08_423993	61	6	SP	SP	NNP
10_1101-2021_01_08_423993	61	7	column	column	NN
10_1101-2021_01_08_423993	61	8	elution	elution	NN
10_1101-2021_01_08_423993	61	9	were	be	VBD
10_1101-2021_01_08_423993	61	10	combined	combine	VBN
10_1101-2021_01_08_423993	61	11	and	and	CC
10_1101-2021_01_08_423993	61	12	concentrated	concentrate	VBN
10_1101-2021_01_08_423993	61	13	to	to	IN
10_1101-2021_01_08_423993	61	14	1	1	CD
10_1101-2021_01_08_423993	61	15	mL	ml	NN
10_1101-2021_01_08_423993	61	16	using	use	VBG
10_1101-2021_01_08_423993	61	17	a	a	DT
10_1101-2021_01_08_423993	61	18	30	30	CD
10_1101-2021_01_08_423993	61	19	kDa	kda	NN
10_1101-2021_01_08_423993	61	20	MWCO	mwco	NN
10_1101-2021_01_08_423993	61	21	centrifugal	centrifugal	JJ
10_1101-2021_01_08_423993	61	22	concentrator	concentrator	NN
10_1101-2021_01_08_423993	61	23	.	.	.
10_1101-2021_01_08_423993	62	1	The	the	DT
10_1101-2021_01_08_423993	62	2	protein	protein	NN
10_1101-2021_01_08_423993	62	3	was	be	VBD
10_1101-2021_01_08_423993	62	4	then	then	RB
10_1101-2021_01_08_423993	62	5	loaded	load	VBN
10_1101-2021_01_08_423993	62	6	on	on	IN
10_1101-2021_01_08_423993	62	7	to	to	IN
10_1101-2021_01_08_423993	62	8	a	a	DT
10_1101-2021_01_08_423993	62	9	Superdex	Superdex	NNP
10_1101-2021_01_08_423993	62	10	75	75	CD
10_1101-2021_01_08_423993	62	11	increase	increase	NN
10_1101-2021_01_08_423993	62	12	10/300	10/300	CD
10_1101-2021_01_08_423993	62	13	GL	GL	NNP
10_1101-2021_01_08_423993	62	14	equilibrated	equilibrate	VBN
10_1101-2021_01_08_423993	62	15	with	with	IN
10_1101-2021_01_08_423993	62	16	SEC	SEC	NNP
10_1101-2021_01_08_423993	62	17	buffer	buffer	NN
10_1101-2021_01_08_423993	62	18	(	(	-LRB-
10_1101-2021_01_08_423993	62	19	25	25	CD
10_1101-2021_01_08_423993	62	20	mM	mM	NNP
10_1101-2021_01_08_423993	62	21	HEPES	hepe	NNS
10_1101-2021_01_08_423993	62	22	pH	pH	NNP
10_1101-2021_01_08_423993	62	23	7.5	7.5	CD
10_1101-2021_01_08_423993	62	24	,	,	,
10_1101-2021_01_08_423993	62	25	300	300	CD
10_1101-2021_01_08_423993	62	26	mM	mM	NNP
10_1101-2021_01_08_423993	62	27	NaCl	NaCl	NNP
10_1101-2021_01_08_423993	62	28	,	,	,
10_1101-2021_01_08_423993	62	29	5	5	CD
10_1101-2021_01_08_423993	62	30	%	%	NN
10_1101-2021_01_08_423993	62	31	(	(	-LRB-
10_1101-2021_01_08_423993	62	32	v	v	NN
10_1101-2021_01_08_423993	62	33	/	/	SYM
10_1101-2021_01_08_423993	62	34	v	v	NN
10_1101-2021_01_08_423993	62	35	)	)	-RRB-
10_1101-2021_01_08_423993	62	36	glycerol	glycerol	NN
10_1101-2021_01_08_423993	62	37	,	,	,
10_1101-2021_01_08_423993	62	38	2	2	CD
10_1101-2021_01_08_423993	62	39	mM	mM	NNP
10_1101-2021_01_08_423993	62	40	TCEP	tcep	NN
10_1101-2021_01_08_423993	62	41	)	)	-RRB-
10_1101-2021_01_08_423993	62	42	.	.	.
10_1101-2021_01_08_423993	63	1	Mass	mass	JJ
10_1101-2021_01_08_423993	63	2	spectrometric	spectrometric	JJ
10_1101-2021_01_08_423993	63	3	analysis	analysis	NN
10_1101-2021_01_08_423993	63	4	of	of	IN
10_1101-2021_01_08_423993	63	5	the	the	DT
10_1101-2021_01_08_423993	63	6	purified	purify	VBN
10_1101-2021_01_08_423993	63	7	proteins	protein	NNS
10_1101-2021_01_08_423993	63	8	revealed	reveal	VBD
10_1101-2021_01_08_423993	63	9	masses	masse	NNS
10_1101-2021_01_08_423993	63	10	of	of	IN
10_1101-2021_01_08_423993	63	11	41716.5	41716.5	CD
10_1101-2021_01_08_423993	63	12	Da	Da	NNP
10_1101-2021_01_08_423993	63	13	,	,	,
10_1101-2021_01_08_423993	63	14	41650.5	41650.5	CD
10_1101-2021_01_08_423993	63	15	Da	Da	NNP
10_1101-2021_01_08_423993	63	16	,	,	,
10_1101-2021_01_08_423993	63	17	41672.2	41672.2	CD
10_1101-2021_01_08_423993	63	18	Da	Da	NNP
10_1101-2021_01_08_423993	63	19	,	,	,
10_1101-2021_01_08_423993	63	20	41639.9	41639.9	CD
10_1101-2021_01_08_423993	63	21	Da	Da	NNP
10_1101-2021_01_08_423993	63	22	for	for	IN
10_1101-2021_01_08_423993	63	23	WT	WT	NNP
10_1101-2021_01_08_423993	63	24	,	,	,
10_1101-2021_01_08_423993	63	25	H35A	H35A	NNP
10_1101-2021_01_08_423993	63	26	,	,	,
10_1101-2021_01_08_423993	63	27	D37A	D37A	NNP
10_1101-2021_01_08_423993	63	28	and	and	CC
10_1101-2021_01_08_423993	63	29	H35D	H35D	NNP
10_1101-2021_01_08_423993	63	30	proteins	protein	NNS
10_1101-2021_01_08_423993	63	31	,	,	,
10_1101-2021_01_08_423993	63	32	respectively	respectively	RB
10_1101-2021_01_08_423993	63	33	.	.	.
10_1101-2021_01_08_423993	64	1	The	the	DT
10_1101-2021_01_08_423993	64	2	calculated	calculated	JJ
10_1101-2021_01_08_423993	64	3	masses	masse	NNS
10_1101-2021_01_08_423993	64	4	are	be	VBP
10_1101-2021_01_08_423993	64	5	41715.09	41715.09	CD
10_1101-2021_01_08_423993	64	6	,	,	,
10_1101-2021_01_08_423993	64	7	41649.2	41649.2	CD
10_1101-2021_01_08_423993	64	8	,	,	,
10_1101-2021_01_08_423993	64	9	41671.2	41671.2	CD
10_1101-2021_01_08_423993	64	10	and	and	CC
10_1101-2021_01_08_423993	64	11	14639.2	14639.2	CD
10_1101-2021_01_08_423993	64	12	,	,	,
10_1101-2021_01_08_423993	64	13	respectively	respectively	RB
10_1101-2021_01_08_423993	64	14	,	,	,
10_1101-2021_01_08_423993	64	15	all	all	DT
10_1101-2021_01_08_423993	64	16	within	within	IN
10_1101-2021_01_08_423993	64	17	1.5	1.5	CD
10_1101-2021_01_08_423993	64	18	Da	Da	NNP
10_1101-2021_01_08_423993	64	19	of	of	IN
10_1101-2021_01_08_423993	64	20	the	the	DT
10_1101-2021_01_08_423993	64	21	measured	measured	JJ
10_1101-2021_01_08_423993	64	22	masses	masse	NNS
10_1101-2021_01_08_423993	64	23	.	.	.
10_1101-2021_01_08_423993	65	1	Expression	expression	NN
10_1101-2021_01_08_423993	65	2	and	and	CC
10_1101-2021_01_08_423993	65	3	purification	purification	NN
10_1101-2021_01_08_423993	65	4	of	of	IN
10_1101-2021_01_08_423993	65	5	WT	WT	NNP
10_1101-2021_01_08_423993	65	6	truncated	truncate	VBD
10_1101-2021_01_08_423993	65	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	65	8	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	65	9	domain	domain	NN
10_1101-2021_01_08_423993	65	10	without	without	IN
10_1101-2021_01_08_423993	65	11	IMAC	IMAC	NNP
10_1101-2021_01_08_423993	65	12	(	(	-LRB-
10_1101-2021_01_08_423993	65	13	aa	aa	NNP
10_1101-2021_01_08_423993	65	14	1	1	CD
10_1101-2021_01_08_423993	65	15	-	-	SYM
10_1101-2021_01_08_423993	65	16	362	362	CD
10_1101-2021_01_08_423993	65	17	)	)	-RRB-
10_1101-2021_01_08_423993	65	18	The	the	DT
10_1101-2021_01_08_423993	65	19	truncated	truncate	VBN
10_1101-2021_01_08_423993	65	20	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	65	21	protein	protein	NN
10_1101-2021_01_08_423993	65	22	was	be	VBD
10_1101-2021_01_08_423993	65	23	expressed	express	VBN
10_1101-2021_01_08_423993	65	24	and	and	CC
10_1101-2021_01_08_423993	65	25	purified	purify	VBN
10_1101-2021_01_08_423993	65	26	in	in	IN
10_1101-2021_01_08_423993	65	27	a	a	DT
10_1101-2021_01_08_423993	65	28	similar	similar	JJ
10_1101-2021_01_08_423993	65	29	manner	manner	NN
10_1101-2021_01_08_423993	65	30	as	as	IN
10_1101-2021_01_08_423993	65	31	described	describe	VBN
10_1101-2021_01_08_423993	65	32	above	above	IN
10_1101-2021_01_08_423993	65	33	except	except	IN
10_1101-2021_01_08_423993	65	34	for	for	IN
10_1101-2021_01_08_423993	65	35	the	the	DT
10_1101-2021_01_08_423993	65	36	first	first	JJ
10_1101-2021_01_08_423993	65	37	purification	purification	NN
10_1101-2021_01_08_423993	65	38	step	step	NN
10_1101-2021_01_08_423993	65	39	.	.	.
10_1101-2021_01_08_423993	66	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	66	2	used	use	VBD
10_1101-2021_01_08_423993	66	3	5	5	CD
10_1101-2021_01_08_423993	66	4	mL	mL	NNP
10_1101-2021_01_08_423993	66	5	HiTrap	HiTrap	NNP
10_1101-2021_01_08_423993	66	6	®	®	NNP
10_1101-2021_01_08_423993	66	7	SP	SP	NNP
10_1101-2021_01_08_423993	66	8	Fast	fast	JJ
10_1101-2021_01_08_423993	66	9	Flow	flow	NN
10_1101-2021_01_08_423993	66	10	(	(	-LRB-
10_1101-2021_01_08_423993	66	11	GE	GE	NNP
10_1101-2021_01_08_423993	66	12	Health	Health	NNP
10_1101-2021_01_08_423993	66	13	Care	Care	NNP
10_1101-2021_01_08_423993	66	14	)	)	-RRB-
10_1101-2021_01_08_423993	66	15	column	column	NN
10_1101-2021_01_08_423993	66	16	as	as	IN
10_1101-2021_01_08_423993	66	17	the	the	DT
10_1101-2021_01_08_423993	66	18	first	first	JJ
10_1101-2021_01_08_423993	66	19	step	step	NN
10_1101-2021_01_08_423993	66	20	of	of	IN
10_1101-2021_01_08_423993	66	21	purification	purification	NN
10_1101-2021_01_08_423993	66	22	.	.	.
10_1101-2021_01_08_423993	67	1	Following	follow	VBG
10_1101-2021_01_08_423993	67	2	an	an	DT
10_1101-2021_01_08_423993	67	3	overnight	overnight	JJ
10_1101-2021_01_08_423993	67	4	TEV	TEV	NNP
10_1101-2021_01_08_423993	67	5	cleavage	cleavage	NN
10_1101-2021_01_08_423993	67	6	the	the	DT
10_1101-2021_01_08_423993	67	7	protein	protein	NN
10_1101-2021_01_08_423993	67	8	was	be	VBD
10_1101-2021_01_08_423993	67	9	subjected	subject	VBN
10_1101-2021_01_08_423993	67	10	to	to	IN
10_1101-2021_01_08_423993	67	11	a	a	DT
10_1101-2021_01_08_423993	67	12	second	second	JJ
10_1101-2021_01_08_423993	67	13	ion	ion	NN
10_1101-2021_01_08_423993	67	14	exchange	exchange	NN
10_1101-2021_01_08_423993	67	15	step	step	NN
10_1101-2021_01_08_423993	67	16	(	(	-LRB-
10_1101-2021_01_08_423993	67	17	5	5	CD
10_1101-2021_01_08_423993	67	18	mL	mL	NNP
10_1101-2021_01_08_423993	67	19	HiTrap	HiTrap	NNP
10_1101-2021_01_08_423993	67	20	®	®	NNP
10_1101-2021_01_08_423993	67	21	SP	SP	NNP
10_1101-2021_01_08_423993	67	22	Fast	fast	JJ
10_1101-2021_01_08_423993	67	23	Flow	flow	NN
10_1101-2021_01_08_423993	67	24	(	(	-LRB-
10_1101-2021_01_08_423993	67	25	GE	GE	NNP
10_1101-2021_01_08_423993	67	26	Health	Health	NNP
10_1101-2021_01_08_423993	67	27	Care	Care	NNP
10_1101-2021_01_08_423993	67	28	)	)	-RRB-
10_1101-2021_01_08_423993	67	29	)	)	-RRB-
10_1101-2021_01_08_423993	67	30	for	for	IN
10_1101-2021_01_08_423993	67	31	the	the	DT
10_1101-2021_01_08_423993	67	32	removal	removal	NN
10_1101-2021_01_08_423993	67	33	of	of	IN
10_1101-2021_01_08_423993	67	34	the	the	DT
10_1101-2021_01_08_423993	67	35	Z	z	JJ
10_1101-2021_01_08_423993	67	36	-	-	HYPH
10_1101-2021_01_08_423993	67	37	Basic	basic	JJ
10_1101-2021_01_08_423993	67	38	protein	protein	NN
10_1101-2021_01_08_423993	67	39	tag	tag	NN
10_1101-2021_01_08_423993	67	40	.	.	.
10_1101-2021_01_08_423993	68	1	The	the	DT
10_1101-2021_01_08_423993	68	2	protein	protein	NN
10_1101-2021_01_08_423993	68	3	was	be	VBD
10_1101-2021_01_08_423993	68	4	further	further	RB
10_1101-2021_01_08_423993	68	5	purified	purify	VBN
10_1101-2021_01_08_423993	68	6	by	by	IN
10_1101-2021_01_08_423993	68	7	size	size	NN
10_1101-2021_01_08_423993	68	8	exclusion	exclusion	NN
10_1101-2021_01_08_423993	68	9	chromatography	chromatography	NN
10_1101-2021_01_08_423993	68	10	(	(	-LRB-
10_1101-2021_01_08_423993	68	11	Highload	Highload	NNP
10_1101-2021_01_08_423993	68	12	®	®	NNPS
10_1101-2021_01_08_423993	68	13	16/200	16/200	CD
10_1101-2021_01_08_423993	68	14	Superdex	superdex	JJ
10_1101-2021_01_08_423993	68	15	®	®	NNP
10_1101-2021_01_08_423993	68	16	200	200	CD
10_1101-2021_01_08_423993	68	17	)	)	-RRB-
10_1101-2021_01_08_423993	68	18	.	.	.
10_1101-2021_01_08_423993	69	1	Cloning	clone	VBG
10_1101-2021_01_08_423993	69	2	,	,	,
10_1101-2021_01_08_423993	69	3	expression	expression	NN
10_1101-2021_01_08_423993	69	4	and	and	CC
10_1101-2021_01_08_423993	69	5	purification	purification	NN
10_1101-2021_01_08_423993	69	6	of	of	IN
10_1101-2021_01_08_423993	69	7	full	full	JJ
10_1101-2021_01_08_423993	69	8	-	-	HYPH
10_1101-2021_01_08_423993	69	9	length	length	NN
10_1101-2021_01_08_423993	69	10	WT	WT	NNP
10_1101-2021_01_08_423993	69	11	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	69	12	(	(	-LRB-
10_1101-2021_01_08_423993	69	13	aa	aa	NNP
10_1101-2021_01_08_423993	69	14	1	1	CD
10_1101-2021_01_08_423993	69	15	-	-	SYM
10_1101-2021_01_08_423993	69	16	692	692	CD
10_1101-2021_01_08_423993	69	17	)	)	-RRB-
10_1101-2021_01_08_423993	69	18	.CC	.CC	:
10_1101-2021_01_08_423993	69	19	-	-	:
10_1101-2021_01_08_423993	69	20	BY	by	IN
10_1101-2021_01_08_423993	69	21	4.0	4.0	CD
10_1101-2021_01_08_423993	69	22	International	international	JJ
10_1101-2021_01_08_423993	69	23	licensemade	licensemade	NN
10_1101-2021_01_08_423993	69	24	available	available	JJ
10_1101-2021_01_08_423993	69	25	under	under	IN
10_1101-2021_01_08_423993	69	26	a	a	DT
10_1101-2021_01_08_423993	69	27	(	(	-LRB-
10_1101-2021_01_08_423993	69	28	which	which	WDT
10_1101-2021_01_08_423993	69	29	was	be	VBD
10_1101-2021_01_08_423993	69	30	not	not	RB
10_1101-2021_01_08_423993	69	31	certified	certify	VBN
10_1101-2021_01_08_423993	69	32	by	by	IN
10_1101-2021_01_08_423993	69	33	peer	peer	NN
10_1101-2021_01_08_423993	69	34	review	review	NN
10_1101-2021_01_08_423993	69	35	)	)	-RRB-
10_1101-2021_01_08_423993	69	36	is	be	VBZ
10_1101-2021_01_08_423993	69	37	the	the	DT
10_1101-2021_01_08_423993	69	38	author	author	NN
10_1101-2021_01_08_423993	69	39	/	/	SYM
10_1101-2021_01_08_423993	69	40	funder	funder	NN
10_1101-2021_01_08_423993	69	41	,	,	,
10_1101-2021_01_08_423993	69	42	who	who	WP
10_1101-2021_01_08_423993	69	43	has	have	VBZ
10_1101-2021_01_08_423993	69	44	granted	grant	VBN
10_1101-2021_01_08_423993	69	45	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	69	46	a	a	DT
10_1101-2021_01_08_423993	69	47	license	license	NN
10_1101-2021_01_08_423993	69	48	to	to	TO
10_1101-2021_01_08_423993	69	49	display	display	VB
10_1101-2021_01_08_423993	69	50	the	the	DT
10_1101-2021_01_08_423993	69	51	preprint	preprint	NN
10_1101-2021_01_08_423993	69	52	in	in	IN
10_1101-2021_01_08_423993	69	53	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	69	54	.	.	.
10_1101-2021_01_08_423993	70	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	70	2	is	be	VBZ
10_1101-2021_01_08_423993	70	3	The	the	DT
10_1101-2021_01_08_423993	70	4	copyright	copyright	NN
10_1101-2021_01_08_423993	70	5	holder	holder	NN
10_1101-2021_01_08_423993	70	6	for	for	IN
10_1101-2021_01_08_423993	70	7	this	this	DT
10_1101-2021_01_08_423993	70	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	70	9	version	version	NN
10_1101-2021_01_08_423993	70	10	posted	post	VBD
10_1101-2021_01_08_423993	70	11	January	January	NNP
10_1101-2021_01_08_423993	70	12	8	8	CD
10_1101-2021_01_08_423993	70	13	,	,	,
10_1101-2021_01_08_423993	70	14	2021	2021	CD
10_1101-2021_01_08_423993	70	15	.	.	.
10_1101-2021_01_08_423993	70	16	;	;	:
10_1101-2021_01_08_423993	70	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	70	18	:	:	:
10_1101-2021_01_08_423993	70	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	70	20	preprint	preprint	NN
10_1101-2021_01_08_423993	70	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	70	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	NNS
10_1101-2021_01_08_423993	70	23	The	the	DT
10_1101-2021_01_08_423993	70	24	full	full	JJ
10_1101-2021_01_08_423993	70	25	-	-	HYPH
10_1101-2021_01_08_423993	70	26	length	length	NN
10_1101-2021_01_08_423993	70	27	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	70	28	encoding	encode	VBG
10_1101-2021_01_08_423993	70	29	construct	construct	NN
10_1101-2021_01_08_423993	70	30	was	be	VBD
10_1101-2021_01_08_423993	70	31	cloned	clone	VBN
10_1101-2021_01_08_423993	70	32	into	into	IN
10_1101-2021_01_08_423993	70	33	pFB	pfb	NN
10_1101-2021_01_08_423993	70	34	-	-	HYPH
10_1101-2021_01_08_423993	70	35	CT10HF	ct10hf	FW
10_1101-2021_01_08_423993	70	36	-	-	HYPH
10_1101-2021_01_08_423993	70	37	LIC	LIC	NNP
10_1101-2021_01_08_423993	70	38	,	,	,
10_1101-2021_01_08_423993	70	39	a	a	DT
10_1101-2021_01_08_423993	70	40	baculovirus	baculovirus	NNP
10_1101-2021_01_08_423993	70	41	expression	expression	NN
10_1101-2021_01_08_423993	70	42	vector	vector	NN
10_1101-2021_01_08_423993	70	43	containing	contain	VBG
10_1101-2021_01_08_423993	70	44	a	a	DT
10_1101-2021_01_08_423993	70	45	C	C	NNP
10_1101-2021_01_08_423993	70	46	-	-	HYPH
10_1101-2021_01_08_423993	70	47	terminal	terminal	JJ
10_1101-2021_01_08_423993	70	48	His10	His10	NNP
10_1101-2021_01_08_423993	70	49	and	and	CC
10_1101-2021_01_08_423993	70	50	FLAG	FLAG	NNP
10_1101-2021_01_08_423993	70	51	tag	tag	NN
10_1101-2021_01_08_423993	70	52	.	.	.
10_1101-2021_01_08_423993	71	1	pFB	pFB	NNP
10_1101-2021_01_08_423993	71	2	-	-	HYPH
10_1101-2021_01_08_423993	71	3	CT10HF	ct10hf	FW
10_1101-2021_01_08_423993	71	4	-	-	HYPH
10_1101-2021_01_08_423993	71	5	LIC	LIC	NNP
10_1101-2021_01_08_423993	71	6	was	be	VBD
10_1101-2021_01_08_423993	71	7	a	a	DT
10_1101-2021_01_08_423993	71	8	gift	gift	NN
10_1101-2021_01_08_423993	71	9	from	from	IN
10_1101-2021_01_08_423993	71	10	Nicola	Nicola	NNP
10_1101-2021_01_08_423993	71	11	Burgess	Burgess	NNP
10_1101-2021_01_08_423993	71	12	-	-	HYPH
10_1101-2021_01_08_423993	71	13	Brown	Brown	NNP
10_1101-2021_01_08_423993	71	14	(	(	-LRB-
10_1101-2021_01_08_423993	71	15	Addgene	Addgene	NNP
10_1101-2021_01_08_423993	71	16	plasmid	plasmid	NN
10_1101-2021_01_08_423993	71	17	#	#	$
10_1101-2021_01_08_423993	71	18	39191	39191	CD
10_1101-2021_01_08_423993	71	19	;	;	:
10_1101-2021_01_08_423993	71	20	http://n2t.net/addgene:39191	http://n2t.net/addgene:39191	NNP
10_1101-2021_01_08_423993	71	21	;	;	:
10_1101-2021_01_08_423993	71	22	RRID	RRID	NNP
10_1101-2021_01_08_423993	71	23	:	:	:
10_1101-2021_01_08_423993	71	24	Addgene_39191	Addgene_39191	NNP
10_1101-2021_01_08_423993	71	25	)	)	-RRB-
10_1101-2021_01_08_423993	71	26	.	.	.
10_1101-2021_01_08_423993	72	1	As	as	IN
10_1101-2021_01_08_423993	72	2	for	for	IN
10_1101-2021_01_08_423993	72	3	the	the	DT
10_1101-2021_01_08_423993	72	4	truncated	truncated	JJ
10_1101-2021_01_08_423993	72	5	protein	protein	NN
10_1101-2021_01_08_423993	72	6	,	,	,
10_1101-2021_01_08_423993	72	7	the	the	DT
10_1101-2021_01_08_423993	72	8	full	full	JJ
10_1101-2021_01_08_423993	72	9	-length	-length	NNP
10_1101-2021_01_08_423993	72	10	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	72	11	gene	gene	NN
10_1101-2021_01_08_423993	72	12	was	be	VBD
10_1101-2021_01_08_423993	72	13	also	also	RB
10_1101-2021_01_08_423993	72	14	cloned	clone	VBN
10_1101-2021_01_08_423993	72	15	using	use	VBG
10_1101-2021_01_08_423993	72	16	ligation	ligation	NN
10_1101-2021_01_08_423993	72	17	independent	independent	JJ
10_1101-2021_01_08_423993	72	18	cloning	cloning	NN
10_1101-2021_01_08_423993	72	19	(	(	-LRB-
10_1101-2021_01_08_423993	72	20	LIC	lic	NN
10_1101-2021_01_08_423993	72	21	)	)	-RRB-
10_1101-2021_01_08_423993	72	22	[	[	-LRB-
10_1101-2021_01_08_423993	72	23	35	35	CD
10_1101-2021_01_08_423993	72	24	]	]	-RRB-
10_1101-2021_01_08_423993	72	25	.	.	.
10_1101-2021_01_08_423993	73	1	The	the	DT
10_1101-2021_01_08_423993	73	2	baculovirus	baculovirus	NNP
10_1101-2021_01_08_423993	73	3	mediated	mediate	VBD
10_1101-2021_01_08_423993	73	4	expression	expression	NN
10_1101-2021_01_08_423993	73	5	of	of	IN
10_1101-2021_01_08_423993	73	6	the	the	DT
10_1101-2021_01_08_423993	73	7	full	full	JJ
10_1101-2021_01_08_423993	73	8	length	length	NN
10_1101-2021_01_08_423993	73	9	DCLRE1C/	DCLRE1C/	NNP
10_1101-2021_01_08_423993	73	10	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	73	11	gene	gene	NN
10_1101-2021_01_08_423993	73	12	was	be	VBD
10_1101-2021_01_08_423993	73	13	performed	perform	VBN
10_1101-2021_01_08_423993	73	14	in	in	IN
10_1101-2021_01_08_423993	73	15	a	a	DT
10_1101-2021_01_08_423993	73	16	manner	manner	NN
10_1101-2021_01_08_423993	73	17	similar	similar	JJ
10_1101-2021_01_08_423993	73	18	to	to	IN
10_1101-2021_01_08_423993	73	19	that	that	DT
10_1101-2021_01_08_423993	73	20	used	use	VBN
10_1101-2021_01_08_423993	73	21	for	for	IN
10_1101-2021_01_08_423993	73	22	the	the	DT
10_1101-2021_01_08_423993	73	23	truncated	truncated	JJ
10_1101-2021_01_08_423993	73	24	protein	protein	NN
10_1101-2021_01_08_423993	73	25	.	.	.
10_1101-2021_01_08_423993	74	1	However	however	RB
10_1101-2021_01_08_423993	74	2	,	,	,
10_1101-2021_01_08_423993	74	3	instead	instead	RB
10_1101-2021_01_08_423993	74	4	of	of	IN
10_1101-2021_01_08_423993	74	5	infection	infection	NN
10_1101-2021_01_08_423993	74	6	with	with	IN
10_1101-2021_01_08_423993	74	7	1.5	1.5	CD
10_1101-2021_01_08_423993	74	8	mL	ml	NN
10_1101-2021_01_08_423993	74	9	of	of	IN
10_1101-2021_01_08_423993	74	10	P2	P2	NNP
10_1101-2021_01_08_423993	74	11	Virus	Virus	NNP
10_1101-2021_01_08_423993	74	12	,	,	,
10_1101-2021_01_08_423993	74	13	3.0	3.0	CD
10_1101-2021_01_08_423993	74	14	mL	ml	NN
10_1101-2021_01_08_423993	74	15	of	of	IN
10_1101-2021_01_08_423993	74	16	P2	P2	NNP
10_1101-2021_01_08_423993	74	17	virus	virus	NN
10_1101-2021_01_08_423993	74	18	was	be	VBD
10_1101-2021_01_08_423993	74	19	used	use	VBN
10_1101-2021_01_08_423993	74	20	to	to	TO
10_1101-2021_01_08_423993	74	21	infect	infect	VB
10_1101-2021_01_08_423993	74	22	Sf9	sf9	JJ
10_1101-2021_01_08_423993	74	23	cells	cell	NNS
10_1101-2021_01_08_423993	74	24	at	at	IN
10_1101-2021_01_08_423993	74	25	2	2	CD
10_1101-2021_01_08_423993	74	26	x	x	SYM
10_1101-2021_01_08_423993	74	27	106	106	CD
10_1101-2021_01_08_423993	74	28	cells/	cells/	NN
10_1101-2021_01_08_423993	74	29	mL	ml	NN
10_1101-2021_01_08_423993	74	30	for	for	IN
10_1101-2021_01_08_423993	74	31	the	the	DT
10_1101-2021_01_08_423993	74	32	expression	expression	NN
10_1101-2021_01_08_423993	74	33	of	of	IN
10_1101-2021_01_08_423993	74	34	the	the	DT
10_1101-2021_01_08_423993	74	35	full	full	JJ
10_1101-2021_01_08_423993	74	36	-	-	HYPH
10_1101-2021_01_08_423993	74	37	length	length	NN
10_1101-2021_01_08_423993	74	38	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	74	39	construct	construct	NN
10_1101-2021_01_08_423993	74	40	.	.	.
10_1101-2021_01_08_423993	75	1	Cell	cell	NN
10_1101-2021_01_08_423993	75	2	harvesting	harvesting	NN
10_1101-2021_01_08_423993	75	3	and	and	CC
10_1101-2021_01_08_423993	75	4	the	the	DT
10_1101-2021_01_08_423993	75	5	initial	initial	JJ
10_1101-2021_01_08_423993	75	6	IMAC	IMAC	NNP
10_1101-2021_01_08_423993	75	7	purification	purification	NN
10_1101-2021_01_08_423993	75	8	steps	step	NNS
10_1101-2021_01_08_423993	75	9	were	be	VBD
10_1101-2021_01_08_423993	75	10	performed	perform	VBN
10_1101-2021_01_08_423993	75	11	as	as	IN
10_1101-2021_01_08_423993	75	12	described	describe	VBN
10_1101-2021_01_08_423993	75	13	for	for	IN
10_1101-2021_01_08_423993	75	14	the	the	DT
10_1101-2021_01_08_423993	75	15	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	75	16	domain	domain	NN
10_1101-2021_01_08_423993	75	17	.	.	.
10_1101-2021_01_08_423993	76	1	Following	follow	VBG
10_1101-2021_01_08_423993	76	2	IMAC	IMAC	NNP
10_1101-2021_01_08_423993	76	3	chromatographic	chromatographic	JJ
10_1101-2021_01_08_423993	76	4	purification	purification	NN
10_1101-2021_01_08_423993	76	5	,	,	,
10_1101-2021_01_08_423993	76	6	TEV	TEV	NNP
10_1101-2021_01_08_423993	76	7	cleavage	cleavage	NN
10_1101-2021_01_08_423993	76	8	overnight	overnight	RB
10_1101-2021_01_08_423993	76	9	in	in	IN
10_1101-2021_01_08_423993	76	10	dialysis	dialysis	NN
10_1101-2021_01_08_423993	76	11	buffer	buffer	NN
10_1101-2021_01_08_423993	76	12	(	(	-LRB-
10_1101-2021_01_08_423993	76	13	50	50	CD
10_1101-2021_01_08_423993	76	14	mM	mM	NNP
10_1101-2021_01_08_423993	76	15	HEPES	hepe	NNS
10_1101-2021_01_08_423993	76	16	pH	pH	NNP
10_1101-2021_01_08_423993	76	17	7.5	7.5	CD
10_1101-2021_01_08_423993	76	18	,	,	,
10_1101-2021_01_08_423993	76	19	0.5	0.5	CD
10_1101-2021_01_08_423993	76	20	M	M	NNP
10_1101-2021_01_08_423993	76	21	NaCl	NaCl	NNP
10_1101-2021_01_08_423993	76	22	,	,	,
10_1101-2021_01_08_423993	76	23	5	5	CD
10_1101-2021_01_08_423993	76	24	%	%	NN
10_1101-2021_01_08_423993	76	25	glycerol	glycerol	NN
10_1101-2021_01_08_423993	76	26	and	and	CC
10_1101-2021_01_08_423993	76	27	1	1	CD
10_1101-2021_01_08_423993	76	28	mM	mM	NNP
10_1101-2021_01_08_423993	76	29	TCEP	tcep	NN
10_1101-2021_01_08_423993	76	30	)	)	-RRB-
10_1101-2021_01_08_423993	76	31	gave	give	VBD
10_1101-2021_01_08_423993	76	32	protein	protein	NN
10_1101-2021_01_08_423993	76	33	which	which	WDT
10_1101-2021_01_08_423993	76	34	was	be	VBD
10_1101-2021_01_08_423993	76	35	then	then	RB
10_1101-2021_01_08_423993	76	36	passed	pass	VBN
10_1101-2021_01_08_423993	76	37	through	through	RP
10_1101-2021_01_08_423993	76	38	a	a	DT
10_1101-2021_01_08_423993	76	39	5	5	CD
10_1101-2021_01_08_423993	76	40	mL	mL	NNP
10_1101-2021_01_08_423993	76	41	Ni	ni	JJ
10_1101-2021_01_08_423993	76	42	-	-	HYPH
10_1101-2021_01_08_423993	76	43	sepharose	sepharose	NN
10_1101-2021_01_08_423993	76	44	column	column	NN
10_1101-2021_01_08_423993	76	45	;	;	:
10_1101-2021_01_08_423993	76	46	the	the	DT
10_1101-2021_01_08_423993	76	47	flowthrough	flowthrough	JJ
10_1101-2021_01_08_423993	76	48	fractions	fraction	NNS
10_1101-2021_01_08_423993	76	49	were	be	VBD
10_1101-2021_01_08_423993	76	50	collected	collect	VBN
10_1101-2021_01_08_423993	76	51	.	.	.
10_1101-2021_01_08_423993	77	1	The	the	DT
10_1101-2021_01_08_423993	77	2	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	77	3	protein	protein	NN
10_1101-2021_01_08_423993	77	4	was	be	VBD
10_1101-2021_01_08_423993	77	5	then	then	RB
10_1101-2021_01_08_423993	77	6	concentrated	concentrate	VBN
10_1101-2021_01_08_423993	77	7	using	use	VBG
10_1101-2021_01_08_423993	77	8	a	a	DT
10_1101-2021_01_08_423993	77	9	centrifugal	centrifugal	JJ
10_1101-2021_01_08_423993	77	10	concentrator	concentrator	NN
10_1101-2021_01_08_423993	77	11	(	(	-LRB-
10_1101-2021_01_08_423993	77	12	Centricon	Centricon	NNP
10_1101-2021_01_08_423993	77	13	,	,	,
10_1101-2021_01_08_423993	77	14	MWCO	MWCO	NNP
10_1101-2021_01_08_423993	77	15	30	30	CD
10_1101-2021_01_08_423993	77	16	kDa	kDa	NNS
10_1101-2021_01_08_423993	77	17	)	)	-RRB-
10_1101-2021_01_08_423993	77	18	before	before	IN
10_1101-2021_01_08_423993	77	19	loading	load	VBG
10_1101-2021_01_08_423993	77	20	on	on	IN
10_1101-2021_01_08_423993	77	21	a	a	DT
10_1101-2021_01_08_423993	77	22	Superdex	Superdex	NNP
10_1101-2021_01_08_423993	77	23	S200	S200	NNP
10_1101-2021_01_08_423993	77	24	HR	hr	NN
10_1101-2021_01_08_423993	77	25	16/60	16/60	CD
10_1101-2021_01_08_423993	77	26	gel	gel	NN
10_1101-2021_01_08_423993	77	27	filtration	filtration	NN
10_1101-2021_01_08_423993	77	28	column	column	NN
10_1101-2021_01_08_423993	77	29	in	in	IN
10_1101-2021_01_08_423993	77	30	dialysis	dialysis	NNP
10_1101-2021_01_08_423993	77	31	buffer	buffer	NN
10_1101-2021_01_08_423993	77	32	.	.	.
10_1101-2021_01_08_423993	78	1	Fractions	fraction	NNS
10_1101-2021_01_08_423993	78	2	containing	contain	VBG
10_1101-2021_01_08_423993	78	3	purified	purify	VBN
10_1101-2021_01_08_423993	78	4	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	78	5	protein	protein	NN
10_1101-2021_01_08_423993	78	6	were	be	VBD
10_1101-2021_01_08_423993	78	7	pooled	pool	VBN
10_1101-2021_01_08_423993	78	8	and	and	CC
10_1101-2021_01_08_423993	78	9	concentrated	concentrate	VBN
10_1101-2021_01_08_423993	78	10	to	to	IN
10_1101-2021_01_08_423993	78	11	10	10	CD
10_1101-2021_01_08_423993	78	12	mg	mg	CD
10_1101-2021_01_08_423993	78	13	/	/	SYM
10_1101-2021_01_08_423993	78	14	mL.	mL.	NNP
10_1101-2021_01_08_423993	79	1	Electospray	electospray	JJ
10_1101-2021_01_08_423993	79	2	mass	mass	NN
10_1101-2021_01_08_423993	79	3	spectrometry	spectrometry	NN
10_1101-2021_01_08_423993	79	4	(	(	-LRB-
10_1101-2021_01_08_423993	79	5	ESI	ESI	NNP
10_1101-2021_01_08_423993	79	6	-	-	HYPH
10_1101-2021_01_08_423993	79	7	QTOF	QTOF	NNP
10_1101-2021_01_08_423993	79	8	)	)	-RRB-
10_1101-2021_01_08_423993	79	9	Reversed	reverse	VBN
10_1101-2021_01_08_423993	79	10	-	-	HYPH
10_1101-2021_01_08_423993	79	11	phase	phase	NN
10_1101-2021_01_08_423993	79	12	chromatography	chromatography	NN
10_1101-2021_01_08_423993	79	13	was	be	VBD
10_1101-2021_01_08_423993	79	14	performed	perform	VBN
10_1101-2021_01_08_423993	79	15	in	in	IN
10_1101-2021_01_08_423993	79	16	-	-	HYPH
10_1101-2021_01_08_423993	79	17	line	line	NN
10_1101-2021_01_08_423993	79	18	prior	prior	RB
10_1101-2021_01_08_423993	79	19	to	to	IN
10_1101-2021_01_08_423993	79	20	mass	mass	NNP
10_1101-2021_01_08_423993	79	21	spectrometry	spectrometry	NNP
10_1101-2021_01_08_423993	79	22	using	use	VBG
10_1101-2021_01_08_423993	79	23	an	an	DT
10_1101-2021_01_08_423993	79	24	Agilent	Agilent	NNP
10_1101-2021_01_08_423993	79	25	1290	1290	CD
10_1101-2021_01_08_423993	79	26	uHPLC	uhplc	NN
10_1101-2021_01_08_423993	79	27	system	system	NN
10_1101-2021_01_08_423993	79	28	(	(	-LRB-
10_1101-2021_01_08_423993	79	29	Agilent	Agilent	NNP
10_1101-2021_01_08_423993	79	30	Technologies	Technologies	NNPS
10_1101-2021_01_08_423993	79	31	inc	inc	NNP
10_1101-2021_01_08_423993	79	32	.	.	NNP
10_1101-2021_01_08_423993	79	33	–	–	:
10_1101-2021_01_08_423993	79	34	Palo	Palo	NNP
10_1101-2021_01_08_423993	79	35	Alto	Alto	NNP
10_1101-2021_01_08_423993	79	36	,	,	,
10_1101-2021_01_08_423993	79	37	CA	CA	NNP
10_1101-2021_01_08_423993	79	38	,	,	,
10_1101-2021_01_08_423993	79	39	USA	USA	NNP
10_1101-2021_01_08_423993	79	40	)	)	-RRB-
10_1101-2021_01_08_423993	79	41	.	.	.
10_1101-2021_01_08_423993	80	1	Concentrated	concentrated	JJ
10_1101-2021_01_08_423993	80	2	protein	protein	NN
10_1101-2021_01_08_423993	80	3	samples	sample	NNS
10_1101-2021_01_08_423993	80	4	were	be	VBD
10_1101-2021_01_08_423993	80	5	diluted	dilute	VBN
10_1101-2021_01_08_423993	80	6	to	to	IN
10_1101-2021_01_08_423993	80	7	0.02	0.02	CD
10_1101-2021_01_08_423993	80	8	mg	mg	NNP
10_1101-2021_01_08_423993	80	9	/	/	SYM
10_1101-2021_01_08_423993	80	10	ml	ml	NN
10_1101-2021_01_08_423993	80	11	in	in	IN
10_1101-2021_01_08_423993	80	12	0.1	0.1	CD
10_1101-2021_01_08_423993	80	13	%	%	NN
10_1101-2021_01_08_423993	80	14	formic	formic	JJ
10_1101-2021_01_08_423993	80	15	acid	acid	NN
10_1101-2021_01_08_423993	80	16	and	and	CC
10_1101-2021_01_08_423993	80	17	50	50	CD
10_1101-2021_01_08_423993	80	18	µl	µl	XX
10_1101-2021_01_08_423993	80	19	was	be	VBD
10_1101-2021_01_08_423993	80	20	injected	inject	VBN
10_1101-2021_01_08_423993	80	21	on	on	IN
10_1101-2021_01_08_423993	80	22	to	to	IN
10_1101-2021_01_08_423993	80	23	a	a	DT
10_1101-2021_01_08_423993	80	24	2.1	2.1	CD
10_1101-2021_01_08_423993	80	25	mm	mm	CD
10_1101-2021_01_08_423993	80	26	x	x	SYM
10_1101-2021_01_08_423993	80	27	12.5	12.5	CD
10_1101-2021_01_08_423993	80	28	mm	mm	NNP
10_1101-2021_01_08_423993	80	29	Zorbax	Zorbax	NNP
10_1101-2021_01_08_423993	80	30	5um	5um	JJ
10_1101-2021_01_08_423993	80	31	300SB	300SB	NNP
10_1101-2021_01_08_423993	80	32	-	-	HYPH
10_1101-2021_01_08_423993	80	33	C3	C3	NNP
10_1101-2021_01_08_423993	80	34	guard	guard	NN
10_1101-2021_01_08_423993	80	35	column	column	NN
10_1101-2021_01_08_423993	80	36	housed	house	VBN
10_1101-2021_01_08_423993	80	37	in	in	IN
10_1101-2021_01_08_423993	80	38	a	a	DT
10_1101-2021_01_08_423993	80	39	column	column	NN
10_1101-2021_01_08_423993	80	40	oven	oven	NN
10_1101-2021_01_08_423993	80	41	set	set	NN
10_1101-2021_01_08_423993	80	42	at	at	IN
10_1101-2021_01_08_423993	80	43	40	40	CD
10_1101-2021_01_08_423993	80	44	oC.	oc.	JJ
10_1101-2021_01_08_423993	81	1	The	the	DT
10_1101-2021_01_08_423993	81	2	solvent	solvent	NN
10_1101-2021_01_08_423993	81	3	system	system	NN
10_1101-2021_01_08_423993	81	4	used	use	VBD
10_1101-2021_01_08_423993	81	5	consisted	consist	VBD
10_1101-2021_01_08_423993	81	6	of	of	IN
10_1101-2021_01_08_423993	81	7	0.1	0.1	CD
10_1101-2021_01_08_423993	81	8	%	%	NN
10_1101-2021_01_08_423993	81	9	formic	formic	NN
10_1101-2021_01_08_423993	81	10	acid	acid	NN
10_1101-2021_01_08_423993	81	11	in	in	IN
10_1101-2021_01_08_423993	81	12	ultra-	ultra-	JJ
10_1101-2021_01_08_423993	81	13	high	high	JJ
10_1101-2021_01_08_423993	81	14	purity	purity	NN
10_1101-2021_01_08_423993	81	15	water	water	NN
10_1101-2021_01_08_423993	81	16	(	(	-LRB-
10_1101-2021_01_08_423993	81	17	Millipore	Millipore	NNP
10_1101-2021_01_08_423993	81	18	)	)	-RRB-
10_1101-2021_01_08_423993	81	19	(	(	-LRB-
10_1101-2021_01_08_423993	81	20	solvent	solvent	NNP
10_1101-2021_01_08_423993	81	21	A	a	NN
10_1101-2021_01_08_423993	81	22	)	)	-RRB-
10_1101-2021_01_08_423993	81	23	and	and	CC
10_1101-2021_01_08_423993	81	24	0.1	0.1	CD
10_1101-2021_01_08_423993	81	25	%	%	NN
10_1101-2021_01_08_423993	81	26	formic	formic	NN
10_1101-2021_01_08_423993	81	27	acid	acid	NN
10_1101-2021_01_08_423993	81	28	in	in	IN
10_1101-2021_01_08_423993	81	29	methanol	methanol	NN
10_1101-2021_01_08_423993	81	30	(	(	-LRB-
10_1101-2021_01_08_423993	81	31	LC	LC	NNP
10_1101-2021_01_08_423993	81	32	-	-	HYPH
10_1101-2021_01_08_423993	81	33	MS	MS	NNP
10_1101-2021_01_08_423993	81	34	grade	grade	NN
10_1101-2021_01_08_423993	81	35	,	,	,
10_1101-2021_01_08_423993	81	36	Chromasolve	Chromasolve	NNP
10_1101-2021_01_08_423993	81	37	)	)	-RRB-
10_1101-2021_01_08_423993	81	38	(	(	-LRB-
10_1101-2021_01_08_423993	81	39	solvent	solvent	NNP
10_1101-2021_01_08_423993	81	40	B	B	NNP
10_1101-2021_01_08_423993	81	41	)	)	-RRB-
10_1101-2021_01_08_423993	81	42	.	.	.
10_1101-2021_01_08_423993	82	1	Chromatography	chromatography	NN
10_1101-2021_01_08_423993	82	2	was	be	VBD
10_1101-2021_01_08_423993	82	3	performed	perform	VBN
10_1101-2021_01_08_423993	82	4	as	as	IN
10_1101-2021_01_08_423993	82	5	follows	follow	VBZ
10_1101-2021_01_08_423993	82	6	:	:	:
10_1101-2021_01_08_423993	82	7	Initial	initial	JJ
10_1101-2021_01_08_423993	82	8	conditions	condition	NNS
10_1101-2021_01_08_423993	82	9	were	be	VBD
10_1101-2021_01_08_423993	82	10	90	90	CD
10_1101-2021_01_08_423993	82	11	%	%	NN
10_1101-2021_01_08_423993	82	12	A	a	NN
10_1101-2021_01_08_423993	82	13	and	and	CC
10_1101-2021_01_08_423993	82	14	10	10	CD
10_1101-2021_01_08_423993	82	15	%	%	NN
10_1101-2021_01_08_423993	82	16	B	b	NN
10_1101-2021_01_08_423993	82	17	and	and	CC
10_1101-2021_01_08_423993	82	18	a	a	DT
10_1101-2021_01_08_423993	82	19	flow	flow	NN
10_1101-2021_01_08_423993	82	20	rate	rate	NN
10_1101-2021_01_08_423993	82	21	of	of	IN
10_1101-2021_01_08_423993	82	22	1.0	1.0	CD
10_1101-2021_01_08_423993	82	23	ml	ml	CD
10_1101-2021_01_08_423993	82	24	/	/	SYM
10_1101-2021_01_08_423993	82	25	min	min	NN
10_1101-2021_01_08_423993	82	26	.	.	.
10_1101-2021_01_08_423993	83	1	A	a	DT
10_1101-2021_01_08_423993	83	2	linear	linear	JJ
10_1101-2021_01_08_423993	83	3	gradient	gradient	NN
10_1101-2021_01_08_423993	83	4	from	from	IN
10_1101-2021_01_08_423993	83	5	10	10	CD
10_1101-2021_01_08_423993	83	6	%	%	NN
10_1101-2021_01_08_423993	83	7	B	b	NN
10_1101-2021_01_08_423993	83	8	to	to	IN
10_1101-2021_01_08_423993	83	9	80	80	CD
10_1101-2021_01_08_423993	83	10	%	%	NN
10_1101-2021_01_08_423993	83	11	B	b	NN
10_1101-2021_01_08_423993	83	12	was	be	VBD
10_1101-2021_01_08_423993	83	13	applied	apply	VBN
10_1101-2021_01_08_423993	83	14	over	over	IN
10_1101-2021_01_08_423993	83	15	35	35	CD
10_1101-2021_01_08_423993	83	16	seconds	second	NNS
10_1101-2021_01_08_423993	83	17	.	.	.
10_1101-2021_01_08_423993	84	1	Elution	elution	NN
10_1101-2021_01_08_423993	84	2	then	then	RB
10_1101-2021_01_08_423993	84	3	proceeded	proceed	VBD
10_1101-2021_01_08_423993	84	4	isocratically	isocratically	RB
10_1101-2021_01_08_423993	84	5	at	at	IN
10_1101-2021_01_08_423993	84	6	95	95	CD
10_1101-2021_01_08_423993	84	7	%	%	NN
10_1101-2021_01_08_423993	84	8	B	b	NN
10_1101-2021_01_08_423993	84	9	for	for	IN
10_1101-2021_01_08_423993	84	10	40	40	CD
10_1101-2021_01_08_423993	84	11	seconds	second	NNS
10_1101-2021_01_08_423993	84	12	followed	follow	VBN
10_1101-2021_01_08_423993	84	13	by	by	IN
10_1101-2021_01_08_423993	84	14	equilibration	equilibration	NN
10_1101-2021_01_08_423993	84	15	at	at	IN
10_1101-2021_01_08_423993	84	16	initial	initial	JJ
10_1101-2021_01_08_423993	84	17	conditions	condition	NNS
10_1101-2021_01_08_423993	84	18	for	for	IN
10_1101-2021_01_08_423993	84	19	a	a	DT
10_1101-2021_01_08_423993	84	20	further	further	JJ
10_1101-2021_01_08_423993	84	21	15	15	CD
10_1101-2021_01_08_423993	84	22	seconds	second	NNS
10_1101-2021_01_08_423993	84	23	.	.	.
10_1101-2021_01_08_423993	85	1	Protein	Protein	NNP
10_1101-2021_01_08_423993	85	2	intact	intact	JJ
10_1101-2021_01_08_423993	85	3	mass	mass	NN
10_1101-2021_01_08_423993	85	4	was	be	VBD
10_1101-2021_01_08_423993	85	5	determined	determine	VBN
10_1101-2021_01_08_423993	85	6	using	use	VBG
10_1101-2021_01_08_423993	85	7	a	a	DT
10_1101-2021_01_08_423993	85	8	6530	6530	CD
10_1101-2021_01_08_423993	85	9	electrospray	electrospray	NNP
10_1101-2021_01_08_423993	85	10	ionisation	ionisation	NN
10_1101-2021_01_08_423993	85	11	quadrupole	quadrupole	JJ
10_1101-2021_01_08_423993	85	12	time	time	NN
10_1101-2021_01_08_423993	85	13	-	-	HYPH
10_1101-2021_01_08_423993	85	14	of	of	IN
10_1101-2021_01_08_423993	85	15	-	-	HYPH
10_1101-2021_01_08_423993	85	16	flight	flight	NN
10_1101-2021_01_08_423993	85	17	mass	mass	NN
10_1101-2021_01_08_423993	85	18	spectrometer	spectrometer	NN
10_1101-2021_01_08_423993	85	19	(	(	-LRB-
10_1101-2021_01_08_423993	85	20	Agilent	Agilent	NNP
10_1101-2021_01_08_423993	85	21	Technologies	Technologies	NNP
10_1101-2021_01_08_423993	85	22	Inc.	Inc.	NNP
10_1101-2021_01_08_423993	85	23	–	–	:
10_1101-2021_01_08_423993	85	24	Palo	Palo	NNP
10_1101-2021_01_08_423993	85	25	Alto	Alto	NNP
10_1101-2021_01_08_423993	85	26	,	,	,
10_1101-2021_01_08_423993	85	27	CA	CA	NNP
10_1101-2021_01_08_423993	85	28	,	,	,
10_1101-2021_01_08_423993	85	29	USA	USA	NNP
10_1101-2021_01_08_423993	85	30	)	)	-RRB-
10_1101-2021_01_08_423993	85	31	.	.	.
10_1101-2021_01_08_423993	86	1	The	the	DT
10_1101-2021_01_08_423993	86	2	instrument	instrument	NN
10_1101-2021_01_08_423993	86	3	was	be	VBD
10_1101-2021_01_08_423993	86	4	configured	configure	VBN
10_1101-2021_01_08_423993	86	5	with	with	IN
10_1101-2021_01_08_423993	86	6	the	the	DT
10_1101-2021_01_08_423993	86	7	standard	standard	JJ
10_1101-2021_01_08_423993	86	8	ESI	ESI	NNP
10_1101-2021_01_08_423993	86	9	source	source	NN
10_1101-2021_01_08_423993	86	10	and	and	CC
10_1101-2021_01_08_423993	86	11	operated	operate	VBN
10_1101-2021_01_08_423993	86	12	in	in	IN
10_1101-2021_01_08_423993	86	13	positive	positive	JJ
10_1101-2021_01_08_423993	86	14	ion	ion	NN
10_1101-2021_01_08_423993	86	15	mode	mode	NN
10_1101-2021_01_08_423993	86	16	.	.	.
10_1101-2021_01_08_423993	87	1	The	the	DT
10_1101-2021_01_08_423993	87	2	ion	ion	NN
10_1101-2021_01_08_423993	87	3	source	source	NN
10_1101-2021_01_08_423993	87	4	was	be	VBD
10_1101-2021_01_08_423993	87	5	operated	operate	VBN
10_1101-2021_01_08_423993	87	6	with	with	IN
10_1101-2021_01_08_423993	87	7	the	the	DT
10_1101-2021_01_08_423993	87	8	capillary	capillary	JJ
10_1101-2021_01_08_423993	87	9	voltage	voltage	NN
10_1101-2021_01_08_423993	87	10	at	at	IN
10_1101-2021_01_08_423993	87	11	4000	4000	CD
10_1101-2021_01_08_423993	87	12	V	v	NN
10_1101-2021_01_08_423993	87	13	,	,	,
10_1101-2021_01_08_423993	87	14	nebulizer	nebulizer	NN
10_1101-2021_01_08_423993	87	15	pressure	pressure	NN
10_1101-2021_01_08_423993	87	16	at	at	IN
10_1101-2021_01_08_423993	87	17	60	60	CD
10_1101-2021_01_08_423993	87	18	psig	psig	NNS
10_1101-2021_01_08_423993	87	19	,	,	,
10_1101-2021_01_08_423993	87	20	drying	dry	VBG
10_1101-2021_01_08_423993	87	21	gas	gas	NN
10_1101-2021_01_08_423993	87	22	at	at	IN
10_1101-2021_01_08_423993	87	23	350oC	350oC	NNP
10_1101-2021_01_08_423993	87	24	and	and	CC
10_1101-2021_01_08_423993	87	25	drying	drying	NN
10_1101-2021_01_08_423993	87	26	gas	gas	NN
10_1101-2021_01_08_423993	87	27	flow	flow	NN
10_1101-2021_01_08_423993	87	28	rate	rate	NN
10_1101-2021_01_08_423993	87	29	at	at	IN
10_1101-2021_01_08_423993	87	30	12	12	CD
10_1101-2021_01_08_423993	87	31	L	L	NNP
10_1101-2021_01_08_423993	87	32	/	/	SYM
10_1101-2021_01_08_423993	87	33	min	min	NN
10_1101-2021_01_08_423993	87	34	.	.	.
10_1101-2021_01_08_423993	88	1	The	the	DT
10_1101-2021_01_08_423993	88	2	instrument	instrument	NN
10_1101-2021_01_08_423993	88	3	ion	ion	NN
10_1101-2021_01_08_423993	88	4	optic	optic	JJ
10_1101-2021_01_08_423993	88	5	voltages	voltage	NNS
10_1101-2021_01_08_423993	88	6	were	be	VBD
10_1101-2021_01_08_423993	88	7	as	as	IN
10_1101-2021_01_08_423993	88	8	follows	follow	VBZ
10_1101-2021_01_08_423993	88	9	:	:	:
10_1101-2021_01_08_423993	88	10	fragmentor	fragmentor	NN
10_1101-2021_01_08_423993	88	11	250	250	CD
10_1101-2021_01_08_423993	88	12	V	v	NN
10_1101-2021_01_08_423993	88	13	,	,	,
10_1101-2021_01_08_423993	88	14	skimmer	skimmer	NN
10_1101-2021_01_08_423993	88	15	60	60	CD
10_1101-2021_01_08_423993	88	16	V	v	NN
10_1101-2021_01_08_423993	88	17	and	and	CC
10_1101-2021_01_08_423993	88	18	octopole	octopole	NNP
10_1101-2021_01_08_423993	88	19	RF	RF	NNP
10_1101-2021_01_08_423993	88	20	250	250	CD
10_1101-2021_01_08_423993	88	21	V.	V.	NNP
10_1101-2021_01_08_423993	88	22	Protein	Protein	NNP
10_1101-2021_01_08_423993	88	23	crystallisation	crystallisation	NN
10_1101-2021_01_08_423993	88	24	and	and	CC
10_1101-2021_01_08_423993	88	25	Soaking	soaking	NN
10_1101-2021_01_08_423993	88	26	.CC	.CC	NFP
10_1101-2021_01_08_423993	88	27	-	-	:
10_1101-2021_01_08_423993	88	28	BY	by	IN
10_1101-2021_01_08_423993	88	29	4.0	4.0	CD
10_1101-2021_01_08_423993	88	30	International	international	JJ
10_1101-2021_01_08_423993	88	31	licensemade	licensemade	NN
10_1101-2021_01_08_423993	88	32	available	available	JJ
10_1101-2021_01_08_423993	88	33	under	under	IN
10_1101-2021_01_08_423993	88	34	a	a	DT
10_1101-2021_01_08_423993	88	35	(	(	-LRB-
10_1101-2021_01_08_423993	88	36	which	which	WDT
10_1101-2021_01_08_423993	88	37	was	be	VBD
10_1101-2021_01_08_423993	88	38	not	not	RB
10_1101-2021_01_08_423993	88	39	certified	certify	VBN
10_1101-2021_01_08_423993	88	40	by	by	IN
10_1101-2021_01_08_423993	88	41	peer	peer	NN
10_1101-2021_01_08_423993	88	42	review	review	NN
10_1101-2021_01_08_423993	88	43	)	)	-RRB-
10_1101-2021_01_08_423993	88	44	is	be	VBZ
10_1101-2021_01_08_423993	88	45	the	the	DT
10_1101-2021_01_08_423993	88	46	author	author	NN
10_1101-2021_01_08_423993	88	47	/	/	SYM
10_1101-2021_01_08_423993	88	48	funder	funder	NN
10_1101-2021_01_08_423993	88	49	,	,	,
10_1101-2021_01_08_423993	88	50	who	who	WP
10_1101-2021_01_08_423993	88	51	has	have	VBZ
10_1101-2021_01_08_423993	88	52	granted	grant	VBN
10_1101-2021_01_08_423993	88	53	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	88	54	a	a	DT
10_1101-2021_01_08_423993	88	55	license	license	NN
10_1101-2021_01_08_423993	88	56	to	to	TO
10_1101-2021_01_08_423993	88	57	display	display	VB
10_1101-2021_01_08_423993	88	58	the	the	DT
10_1101-2021_01_08_423993	88	59	preprint	preprint	NN
10_1101-2021_01_08_423993	88	60	in	in	IN
10_1101-2021_01_08_423993	88	61	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	88	62	.	.	.
10_1101-2021_01_08_423993	89	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	89	2	is	be	VBZ
10_1101-2021_01_08_423993	89	3	The	the	DT
10_1101-2021_01_08_423993	89	4	copyright	copyright	NN
10_1101-2021_01_08_423993	89	5	holder	holder	NN
10_1101-2021_01_08_423993	89	6	for	for	IN
10_1101-2021_01_08_423993	89	7	this	this	DT
10_1101-2021_01_08_423993	89	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	89	9	version	version	NN
10_1101-2021_01_08_423993	89	10	posted	post	VBD
10_1101-2021_01_08_423993	89	11	January	January	NNP
10_1101-2021_01_08_423993	89	12	8	8	CD
10_1101-2021_01_08_423993	89	13	,	,	,
10_1101-2021_01_08_423993	89	14	2021	2021	CD
10_1101-2021_01_08_423993	89	15	.	.	.
10_1101-2021_01_08_423993	89	16	;	;	:
10_1101-2021_01_08_423993	89	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	89	18	:	:	:
10_1101-2021_01_08_423993	89	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	89	20	preprint	preprint	NN
10_1101-2021_01_08_423993	89	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	89	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	89	23	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	89	24	(	(	-LRB-
10_1101-2021_01_08_423993	89	25	PDB:6TT5	PDB:6TT5	NNP
10_1101-2021_01_08_423993	89	26	)	)	-RRB-
10_1101-2021_01_08_423993	89	27	was	be	VBD
10_1101-2021_01_08_423993	89	28	crystallised	crystallise	VBN
10_1101-2021_01_08_423993	89	29	using	use	VBG
10_1101-2021_01_08_423993	89	30	the	the	DT
10_1101-2021_01_08_423993	89	31	sitting	sit	VBG
10_1101-2021_01_08_423993	89	32	drop	drop	NN
10_1101-2021_01_08_423993	89	33	vapour	vapour	NNP
10_1101-2021_01_08_423993	89	34	diffusion	diffusion	NN
10_1101-2021_01_08_423993	89	35	method	method	NN
10_1101-2021_01_08_423993	89	36	by	by	IN
10_1101-2021_01_08_423993	89	37	mixing	mix	VBG
10_1101-2021_01_08_423993	89	38	50	50	CD
10_1101-2021_01_08_423993	89	39	nL	nL	NNP
10_1101-2021_01_08_423993	89	40	protein	protein	NN
10_1101-2021_01_08_423993	89	41	with	with	IN
10_1101-2021_01_08_423993	89	42	50	50	CD
10_1101-2021_01_08_423993	89	43	nL	nL	NNP
10_1101-2021_01_08_423993	89	44	crystallisation	crystallisation	NN
10_1101-2021_01_08_423993	89	45	solution	solution	NN
10_1101-2021_01_08_423993	89	46	comprising	comprise	VBG
10_1101-2021_01_08_423993	89	47	0.2	0.2	CD
10_1101-2021_01_08_423993	89	48	M	m	NN
10_1101-2021_01_08_423993	89	49	ammonium	ammonium	NN
10_1101-2021_01_08_423993	89	50	chloride	chloride	NN
10_1101-2021_01_08_423993	89	51	,	,	,
10_1101-2021_01_08_423993	89	52	20	20	CD
10_1101-2021_01_08_423993	89	53	%	%	NN
10_1101-2021_01_08_423993	89	54	(	(	-LRB-
10_1101-2021_01_08_423993	89	55	v	v	NN
10_1101-2021_01_08_423993	89	56	/	/	SYM
10_1101-2021_01_08_423993	89	57	v	v	NN
10_1101-2021_01_08_423993	89	58	)	)	-RRB-
10_1101-2021_01_08_423993	89	59	PEG	PEG	NNP
10_1101-2021_01_08_423993	89	60	3350	3350	CD
10_1101-2021_01_08_423993	89	61	.	.	.
10_1101-2021_01_08_423993	90	1	Crystals	crystal	NNS
10_1101-2021_01_08_423993	90	2	grew	grow	VBD
10_1101-2021_01_08_423993	90	3	after	after	RB
10_1101-2021_01_08_423993	90	4	2	2	CD
10_1101-2021_01_08_423993	90	5	weeks	week	NNS
10_1101-2021_01_08_423993	90	6	and	and	CC
10_1101-2021_01_08_423993	90	7	reached	reach	VBN
10_1101-2021_01_08_423993	90	8	maximum	maximum	JJ
10_1101-2021_01_08_423993	90	9	size	size	NN
10_1101-2021_01_08_423993	90	10	within	within	IN
10_1101-2021_01_08_423993	90	11	3	3	CD
10_1101-2021_01_08_423993	90	12	weeks	week	NNS
10_1101-2021_01_08_423993	90	13	.	.	.
10_1101-2021_01_08_423993	91	1	An	an	DT
10_1101-2021_01_08_423993	91	2	unliganded	unliganded	JJ
10_1101-2021_01_08_423993	91	3	crystal	crystal	NN
10_1101-2021_01_08_423993	91	4	was	be	VBD
10_1101-2021_01_08_423993	91	5	flash	flash	NN
10_1101-2021_01_08_423993	91	6	frozen	frozen	JJ
10_1101-2021_01_08_423993	91	7	in	in	IN
10_1101-2021_01_08_423993	91	8	liquid	liquid	JJ
10_1101-2021_01_08_423993	91	9	nitrogen	nitrogen	NN
10_1101-2021_01_08_423993	91	10	,	,	,
10_1101-2021_01_08_423993	91	11	cryoprotected	cryoprotecte	VBN
10_1101-2021_01_08_423993	91	12	with	with	IN
10_1101-2021_01_08_423993	91	13	the	the	DT
10_1101-2021_01_08_423993	91	14	mother	mother	NN
10_1101-2021_01_08_423993	91	15	liquor	liquor	NN
10_1101-2021_01_08_423993	91	16	supplemented	supplement	VBN
10_1101-2021_01_08_423993	91	17	with	with	IN
10_1101-2021_01_08_423993	91	18	20	20	CD
10_1101-2021_01_08_423993	91	19	%	%	NN
10_1101-2021_01_08_423993	91	20	(	(	-LRB-
10_1101-2021_01_08_423993	91	21	v	v	NN
10_1101-2021_01_08_423993	91	22	/	/	SYM
10_1101-2021_01_08_423993	91	23	v	v	NN
10_1101-2021_01_08_423993	91	24	)	)	-RRB-
10_1101-2021_01_08_423993	91	25	ethylene	ethylene	NN
10_1101-2021_01_08_423993	91	26	glycol	glycol	NN
10_1101-2021_01_08_423993	91	27	solution	solution	NN
10_1101-2021_01_08_423993	91	28	.	.	.
10_1101-2021_01_08_423993	92	1	The	the	DT
10_1101-2021_01_08_423993	92	2	non	non	JJ
10_1101-2021_01_08_423993	92	3	-	-	JJ
10_1101-2021_01_08_423993	92	4	IMAC	imac	JJ
10_1101-2021_01_08_423993	92	5	purified	purify	VBN
10_1101-2021_01_08_423993	92	6	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	92	7	(	(	-LRB-
10_1101-2021_01_08_423993	92	8	PDB:7AF1	PDB:7AF1	NNP
10_1101-2021_01_08_423993	92	9	)	)	-RRB-
10_1101-2021_01_08_423993	92	10	was	be	VBD
10_1101-2021_01_08_423993	92	11	crystallised	crystallise	VBN
10_1101-2021_01_08_423993	92	12	in	in	IN
10_1101-2021_01_08_423993	92	13	a	a	DT
10_1101-2021_01_08_423993	92	14	similar	similar	JJ
10_1101-2021_01_08_423993	92	15	manner	manner	NN
10_1101-2021_01_08_423993	92	16	,	,	,
10_1101-2021_01_08_423993	92	17	with	with	IN
10_1101-2021_01_08_423993	92	18	the	the	DT
10_1101-2021_01_08_423993	92	19	addition	addition	NN
10_1101-2021_01_08_423993	92	20	of	of	IN
10_1101-2021_01_08_423993	92	21	20	20	CD
10_1101-2021_01_08_423993	92	22	nL	nL	NNP
10_1101-2021_01_08_423993	92	23	of	of	IN
10_1101-2021_01_08_423993	92	24	crystal	crystal	NN
10_1101-2021_01_08_423993	92	25	seed	seed	NN
10_1101-2021_01_08_423993	92	26	solution	solution	NN
10_1101-2021_01_08_423993	92	27	obtained	obtain	VBN
10_1101-2021_01_08_423993	92	28	from	from	IN
10_1101-2021_01_08_423993	92	29	previous	previous	JJ
10_1101-2021_01_08_423993	92	30	crystallisation	crystallisation	NN
10_1101-2021_01_08_423993	92	31	experiment	experiment	NN
10_1101-2021_01_08_423993	92	32	.	.	.
10_1101-2021_01_08_423993	93	1	The	the	DT
10_1101-2021_01_08_423993	93	2	crystals	crystal	NNS
10_1101-2021_01_08_423993	93	3	were	be	VBD
10_1101-2021_01_08_423993	93	4	grown	grow	VBN
10_1101-2021_01_08_423993	93	5	in	in	IN
10_1101-2021_01_08_423993	93	6	a	a	DT
10_1101-2021_01_08_423993	93	7	solution	solution	NN
10_1101-2021_01_08_423993	93	8	comprising	comprise	VBG
10_1101-2021_01_08_423993	93	9	0.25	0.25	CD
10_1101-2021_01_08_423993	93	10	M	M	NNP
10_1101-2021_01_08_423993	93	11	ammonium	ammonium	NN
10_1101-2021_01_08_423993	93	12	chloride	chloride	NN
10_1101-2021_01_08_423993	93	13	and	and	CC
10_1101-2021_01_08_423993	93	14	30	30	CD
10_1101-2021_01_08_423993	93	15	%	%	NN
10_1101-2021_01_08_423993	93	16	(	(	-LRB-
10_1101-2021_01_08_423993	93	17	v	v	NN
10_1101-2021_01_08_423993	93	18	/	/	SYM
10_1101-2021_01_08_423993	93	19	v	v	NN
10_1101-2021_01_08_423993	93	20	)	)	-RRB-
10_1101-2021_01_08_423993	93	21	PEG	PEG	NNP
10_1101-2021_01_08_423993	93	22	3350	3350	CD
10_1101-2021_01_08_423993	93	23	at	at	IN
10_1101-2021_01_08_423993	93	24	4	4	CD
10_1101-2021_01_08_423993	93	25	°	°	NNS
10_1101-2021_01_08_423993	93	26	C	C	NNP
10_1101-2021_01_08_423993	93	27	.	.	.
10_1101-2021_01_08_423993	94	1	Crystals	crystal	NNS
10_1101-2021_01_08_423993	94	2	grew	grow	VBD
10_1101-2021_01_08_423993	94	3	after	after	IN
10_1101-2021_01_08_423993	94	4	one	one	CD
10_1101-2021_01_08_423993	94	5	day	day	NN
10_1101-2021_01_08_423993	94	6	and	and	CC
10_1101-2021_01_08_423993	94	7	reached	reach	VBD
10_1101-2021_01_08_423993	94	8	a	a	DT
10_1101-2021_01_08_423993	94	9	maximum	maximum	JJ
10_1101-2021_01_08_423993	94	10	size	size	NN
10_1101-2021_01_08_423993	94	11	within	within	IN
10_1101-2021_01_08_423993	94	12	one	one	CD
10_1101-2021_01_08_423993	94	13	week	week	NN
10_1101-2021_01_08_423993	94	14	.	.	.
10_1101-2021_01_08_423993	95	1	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	95	2	variants	variant	NNS
10_1101-2021_01_08_423993	95	3	(	(	-LRB-
10_1101-2021_01_08_423993	95	4	mutants	mutant	NNS
10_1101-2021_01_08_423993	95	5	H33A	H33A	NNP
10_1101-2021_01_08_423993	95	6	and	and	CC
10_1101-2021_01_08_423993	95	7	H35D	H35D	NNP
10_1101-2021_01_08_423993	95	8	)	)	-RRB-
10_1101-2021_01_08_423993	95	9	were	be	VBD
10_1101-2021_01_08_423993	95	10	crystallised	crystallise	VBN
10_1101-2021_01_08_423993	95	11	using	use	VBG
10_1101-2021_01_08_423993	95	12	the	the	DT
10_1101-2021_01_08_423993	95	13	sitting	sit	VBG
10_1101-2021_01_08_423993	95	14	drop	drop	NN
10_1101-2021_01_08_423993	95	15	vapour	vapour	NNP
10_1101-2021_01_08_423993	95	16	diffusion	diffusion	NN
10_1101-2021_01_08_423993	95	17	method	method	NN
10_1101-2021_01_08_423993	95	18	by	by	IN
10_1101-2021_01_08_423993	95	19	mixing	mix	VBG
10_1101-2021_01_08_423993	95	20	50	50	CD
10_1101-2021_01_08_423993	95	21	nL	nL	NNP
10_1101-2021_01_08_423993	95	22	protein	protein	NN
10_1101-2021_01_08_423993	95	23	with	with	IN
10_1101-2021_01_08_423993	95	24	50	50	CD
10_1101-2021_01_08_423993	95	25	nL	nL	NNP
10_1101-2021_01_08_423993	95	26	crystallisation	crystallisation	NN
10_1101-2021_01_08_423993	95	27	solution	solution	NN
10_1101-2021_01_08_423993	95	28	comprising	comprise	VBG
10_1101-2021_01_08_423993	95	29	0.1	0.1	CD
10_1101-2021_01_08_423993	95	30	M	M	NNP
10_1101-2021_01_08_423993	95	31	sodium	sodium	NN
10_1101-2021_01_08_423993	95	32	citrate	citrate	NN
10_1101-2021_01_08_423993	95	33	pH	pH	NNP
10_1101-2021_01_08_423993	95	34	5.5	5.5	CD
10_1101-2021_01_08_423993	95	35	,	,	,
10_1101-2021_01_08_423993	95	36	20	20	CD
10_1101-2021_01_08_423993	95	37	%	%	NN
10_1101-2021_01_08_423993	95	38	PEG	peg	NN
10_1101-2021_01_08_423993	95	39	3350	3350	CD
10_1101-2021_01_08_423993	95	40	,	,	,
10_1101-2021_01_08_423993	95	41	while	while	IN
10_1101-2021_01_08_423993	95	42	the	the	DT
10_1101-2021_01_08_423993	95	43	D37A	D37A	NNP
10_1101-2021_01_08_423993	95	44	was	be	VBD
10_1101-2021_01_08_423993	95	45	crystalised	crystalise	VBN
10_1101-2021_01_08_423993	95	46	in	in	IN
10_1101-2021_01_08_423993	95	47	0.2	0.2	CD
10_1101-2021_01_08_423993	95	48	M	M	NNP
10_1101-2021_01_08_423993	95	49	ammonium	ammonium	NN
10_1101-2021_01_08_423993	95	50	acetate	acetate	NN
10_1101-2021_01_08_423993	95	51	,	,	,
10_1101-2021_01_08_423993	95	52	0.1	0.1	CD
10_1101-2021_01_08_423993	95	53	M	m	CD
10_1101-2021_01_08_423993	95	54	bis	bis	NN
10_1101-2021_01_08_423993	95	55	-	-	HYPH
10_1101-2021_01_08_423993	95	56	TRIS	tris	NN
10_1101-2021_01_08_423993	95	57	pH	pH	NNP
10_1101-2021_01_08_423993	95	58	5.5	5.5	CD
10_1101-2021_01_08_423993	95	59	,	,	,
10_1101-2021_01_08_423993	95	60	25	25	CD
10_1101-2021_01_08_423993	95	61	%	%	NN
10_1101-2021_01_08_423993	95	62	PEG	PEG	NNP
10_1101-2021_01_08_423993	95	63	3350	3350	CD
10_1101-2021_01_08_423993	95	64	.	.	.
10_1101-2021_01_08_423993	96	1	All	all	DT
10_1101-2021_01_08_423993	96	2	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	96	3	variants	variant	NNS
10_1101-2021_01_08_423993	96	4	were	be	VBD
10_1101-2021_01_08_423993	96	5	crystalised	crystalise	VBN
10_1101-2021_01_08_423993	96	6	in	in	IN
10_1101-2021_01_08_423993	96	7	the	the	DT
10_1101-2021_01_08_423993	96	8	presence	presence	NN
10_1101-2021_01_08_423993	96	9	of	of	IN
10_1101-2021_01_08_423993	96	10	20	20	CD
10_1101-2021_01_08_423993	96	11	nL	nl	NN
10_1101-2021_01_08_423993	96	12	of	of	IN
10_1101-2021_01_08_423993	96	13	crystal	crystal	NN
10_1101-2021_01_08_423993	96	14	seed	seed	NN
10_1101-2021_01_08_423993	96	15	solution	solution	NN
10_1101-2021_01_08_423993	96	16	obtained	obtain	VBN
10_1101-2021_01_08_423993	96	17	from	from	IN
10_1101-2021_01_08_423993	96	18	previous	previous	JJ
10_1101-2021_01_08_423993	96	19	crystallisation	crystallisation	NN
10_1101-2021_01_08_423993	96	20	experiment	experiment	NN
10_1101-2021_01_08_423993	96	21	.	.	.
10_1101-2021_01_08_423993	97	1	Crystals	crystal	NNS
10_1101-2021_01_08_423993	97	2	grew	grow	VBD
10_1101-2021_01_08_423993	97	3	after	after	IN
10_1101-2021_01_08_423993	97	4	one	one	CD
10_1101-2021_01_08_423993	97	5	day	day	NN
10_1101-2021_01_08_423993	97	6	at	at	IN
10_1101-2021_01_08_423993	97	7	4	4	CD
10_1101-2021_01_08_423993	97	8	°	°	NNS
10_1101-2021_01_08_423993	97	9	C	C	NNP
10_1101-2021_01_08_423993	97	10	.	.	.
10_1101-2021_01_08_423993	98	1	and	and	CC
10_1101-2021_01_08_423993	98	2	reached	reach	VBN
10_1101-2021_01_08_423993	98	3	maximum	maximum	JJ
10_1101-2021_01_08_423993	98	4	size	size	NN
10_1101-2021_01_08_423993	98	5	within	within	IN
10_1101-2021_01_08_423993	98	6	one	one	CD
10_1101-2021_01_08_423993	98	7	week	week	NN
10_1101-2021_01_08_423993	98	8	Data	Data	NNP
10_1101-2021_01_08_423993	98	9	collection	collection	NN
10_1101-2021_01_08_423993	98	10	and	and	CC
10_1101-2021_01_08_423993	98	11	refinements	refinement	VBZ
10_1101-2021_01_08_423993	98	12	Data	Data	NNPS
10_1101-2021_01_08_423993	98	13	were	be	VBD
10_1101-2021_01_08_423993	98	14	collected	collect	VBN
10_1101-2021_01_08_423993	98	15	at	at	IN
10_1101-2021_01_08_423993	98	16	Diamond	Diamond	NNP
10_1101-2021_01_08_423993	98	17	Light	Light	NNP
10_1101-2021_01_08_423993	98	18	Source	Source	NNP
10_1101-2021_01_08_423993	98	19	I04	I04	NNP
10_1101-2021_01_08_423993	98	20	,	,	,
10_1101-2021_01_08_423993	98	21	I03	I03	NNP
10_1101-2021_01_08_423993	98	22	,	,	,
10_1101-2021_01_08_423993	98	23	or	or	CC
10_1101-2021_01_08_423993	98	24	I24	I24	NNP
10_1101-2021_01_08_423993	98	25	beamlines	beamline	NNS
10_1101-2021_01_08_423993	98	26	.	.	.
10_1101-2021_01_08_423993	99	1	Diffraction	diffraction	NN
10_1101-2021_01_08_423993	99	2	data	datum	NNS
10_1101-2021_01_08_423993	99	3	were	be	VBD
10_1101-2021_01_08_423993	99	4	processed	process	VBN
10_1101-2021_01_08_423993	99	5	using	use	VBG
10_1101-2021_01_08_423993	99	6	DIALS	dial	NNS
10_1101-2021_01_08_423993	99	7	[	[	-LRB-
10_1101-2021_01_08_423993	99	8	37	37	CD
10_1101-2021_01_08_423993	99	9	]	]	-RRB-
10_1101-2021_01_08_423993	99	10	and	and	CC
10_1101-2021_01_08_423993	99	11	structures	structure	NNS
10_1101-2021_01_08_423993	99	12	were	be	VBD
10_1101-2021_01_08_423993	99	13	solved	solve	VBN
10_1101-2021_01_08_423993	99	14	by	by	IN
10_1101-2021_01_08_423993	99	15	molecular	molecular	JJ
10_1101-2021_01_08_423993	99	16	replacement	replacement	NN
10_1101-2021_01_08_423993	99	17	using	use	VBG
10_1101-2021_01_08_423993	99	18	PHASER	PHASER	NNP
10_1101-2021_01_08_423993	99	19	[	[	-LRB-
10_1101-2021_01_08_423993	99	20	38	38	CD
10_1101-2021_01_08_423993	99	21	]	]	-RRB-
10_1101-2021_01_08_423993	99	22	and	and	CC
10_1101-2021_01_08_423993	99	23	the	the	DT
10_1101-2021_01_08_423993	99	24	PDB	PDB	NNP
10_1101-2021_01_08_423993	99	25	coordinates	coordinate	VBZ
10_1101-2021_01_08_423993	99	26	5Q2A.	5q2a.	CD
10_1101-2021_01_08_423993	100	1	Model	model	NN
10_1101-2021_01_08_423993	100	2	building	building	NN
10_1101-2021_01_08_423993	100	3	and	and	CC
10_1101-2021_01_08_423993	100	4	the	the	DT
10_1101-2021_01_08_423993	100	5	addition	addition	NN
10_1101-2021_01_08_423993	100	6	of	of	IN
10_1101-2021_01_08_423993	100	7	water	water	NN
10_1101-2021_01_08_423993	100	8	molecules	molecule	NNS
10_1101-2021_01_08_423993	100	9	were	be	VBD
10_1101-2021_01_08_423993	100	10	performed	perform	VBN
10_1101-2021_01_08_423993	100	11	in	in	IN
10_1101-2021_01_08_423993	100	12	COOT	COOT	NNP
10_1101-2021_01_08_423993	100	13	[	[	-LRB-
10_1101-2021_01_08_423993	100	14	39	39	CD
10_1101-2021_01_08_423993	100	15	]	]	-RRB-
10_1101-2021_01_08_423993	100	16	and	and	CC
10_1101-2021_01_08_423993	100	17	structures	structure	NNS
10_1101-2021_01_08_423993	100	18	refined	refine	VBD
10_1101-2021_01_08_423993	100	19	using	use	VBG
10_1101-2021_01_08_423993	100	20	REFMAC	REFMAC	NNP
10_1101-2021_01_08_423993	100	21	[	[	-LRB-
10_1101-2021_01_08_423993	100	22	40	40	CD
10_1101-2021_01_08_423993	100	23	]	]	-RRB-
10_1101-2021_01_08_423993	100	24	.	.	.
10_1101-2021_01_08_423993	101	1	Data	datum	NNS
10_1101-2021_01_08_423993	101	2	collection	collection	NN
10_1101-2021_01_08_423993	101	3	and	and	CC
10_1101-2021_01_08_423993	101	4	refinement	refinement	JJ
10_1101-2021_01_08_423993	101	5	statistics	statistic	NNS
10_1101-2021_01_08_423993	101	6	are	be	VBP
10_1101-2021_01_08_423993	101	7	given	give	VBN
10_1101-2021_01_08_423993	101	8	in	in	IN
10_1101-2021_01_08_423993	101	9	Table	table	NN
10_1101-2021_01_08_423993	101	10	I.	i.	NN
10_1101-2021_01_08_423993	102	1	The	the	DT
10_1101-2021_01_08_423993	102	2	X	X	NNP
10_1101-2021_01_08_423993	102	3	-	-	NN
10_1101-2021_01_08_423993	102	4	ray	ray	NNP
10_1101-2021_01_08_423993	102	5	fluorescence	fluorescence	NN
10_1101-2021_01_08_423993	102	6	data	datum	NNS
10_1101-2021_01_08_423993	102	7	was	be	VBD
10_1101-2021_01_08_423993	102	8	collected	collect	VBN
10_1101-2021_01_08_423993	102	9	at	at	IN
10_1101-2021_01_08_423993	102	10	Diamond	Diamond	NNP
10_1101-2021_01_08_423993	102	11	Light	Light	NNP
10_1101-2021_01_08_423993	102	12	Source	Source	NNP
10_1101-2021_01_08_423993	102	13	I03	I03	NNP
10_1101-2021_01_08_423993	102	14	(	(	-LRB-
10_1101-2021_01_08_423993	102	15	6TT5	6tt5	LS
10_1101-2021_01_08_423993	102	16	)	)	-RRB-
10_1101-2021_01_08_423993	102	17	using	use	VBG
10_1101-2021_01_08_423993	102	18	100	100	CD
10_1101-2021_01_08_423993	102	19	%	%	NN
10_1101-2021_01_08_423993	102	20	transmission	transmission	NN
10_1101-2021_01_08_423993	102	21	and	and	CC
10_1101-2021_01_08_423993	102	22	12.7	12.7	CD
10_1101-2021_01_08_423993	102	23	eV	eV	NNS
10_1101-2021_01_08_423993	102	24	,	,	,
10_1101-2021_01_08_423993	102	25	and	and	CC
10_1101-2021_01_08_423993	102	26	I24	I24	NNP
10_1101-2021_01_08_423993	102	27	(	(	-LRB-
10_1101-2021_01_08_423993	102	28	7AF1	7af1	LS
10_1101-2021_01_08_423993	102	29	)	)	-RRB-
10_1101-2021_01_08_423993	102	30	using	use	VBG
10_1101-2021_01_08_423993	102	31	1	1	CD
10_1101-2021_01_08_423993	102	32	%	%	NN
10_1101-2021_01_08_423993	102	33	transmission	transmission	NN
10_1101-2021_01_08_423993	102	34	and	and	CC
10_1101-2021_01_08_423993	102	35	12.8	12.8	CD
10_1101-2021_01_08_423993	102	36	eV	ev	FW
10_1101-2021_01_08_423993	102	37	(	(	-LRB-
10_1101-2021_01_08_423993	102	38	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	102	39	.	.	.
10_1101-2021_01_08_423993	103	1	Figure	figure	NN
10_1101-2021_01_08_423993	103	2	1	1	CD
10_1101-2021_01_08_423993	103	3	)	)	-RRB-
10_1101-2021_01_08_423993	103	4	.	.	.
10_1101-2021_01_08_423993	104	1	Generation	generation	NN
10_1101-2021_01_08_423993	104	2	of	of	IN
10_1101-2021_01_08_423993	104	3	3-radiolabelled	3-radiolabelled	CD
10_1101-2021_01_08_423993	104	4	substrates	substrate	NNS
10_1101-2021_01_08_423993	104	5	10	10	CD
10_1101-2021_01_08_423993	104	6	pmol	pmol	NN
10_1101-2021_01_08_423993	104	7	of	of	IN
10_1101-2021_01_08_423993	104	8	single	single	JJ
10_1101-2021_01_08_423993	104	9	-	-	HYPH
10_1101-2021_01_08_423993	104	10	stranded	strand	VBN
10_1101-2021_01_08_423993	104	11	DNA	dna	NN
10_1101-2021_01_08_423993	104	12	(	(	-LRB-
10_1101-2021_01_08_423993	104	13	Eurofins	Eurofins	NNP
10_1101-2021_01_08_423993	104	14	MWG	MWG	NNP
10_1101-2021_01_08_423993	104	15	Operon	Operon	NNP
10_1101-2021_01_08_423993	104	16	,	,	,
10_1101-2021_01_08_423993	104	17	Germany	Germany	NNP
10_1101-2021_01_08_423993	104	18	)	)	-RRB-
10_1101-2021_01_08_423993	104	19	were	be	VBD
10_1101-2021_01_08_423993	104	20	labelled	label	VBN
10_1101-2021_01_08_423993	104	21	with	with	IN
10_1101-2021_01_08_423993	104	22	3.3	3.3	CD
10_1101-2021_01_08_423993	104	23	pmol	pmol	NN
10_1101-2021_01_08_423993	104	24	of	of	IN
10_1101-2021_01_08_423993	104	25	α-32P	α-32p	NN
10_1101-2021_01_08_423993	104	26	-	-	HYPH
10_1101-2021_01_08_423993	104	27	dATP	datp	NN
10_1101-2021_01_08_423993	104	28	(	(	-LRB-
10_1101-2021_01_08_423993	104	29	Perkin	Perkin	NNP
10_1101-2021_01_08_423993	104	30	Elmer	Elmer	NNP
10_1101-2021_01_08_423993	104	31	)	)	-RRB-
10_1101-2021_01_08_423993	104	32	by	by	IN
10_1101-2021_01_08_423993	104	33	incubation	incubation	NN
10_1101-2021_01_08_423993	104	34	with	with	IN
10_1101-2021_01_08_423993	104	35	terminal	terminal	JJ
10_1101-2021_01_08_423993	104	36	deoxynucleotidyl	deoxynucleotidyl	NN
10_1101-2021_01_08_423993	104	37	transferase	transferase	NN
10_1101-2021_01_08_423993	104	38	(	(	-LRB-
10_1101-2021_01_08_423993	104	39	TdT	TdT	NNP
10_1101-2021_01_08_423993	104	40	,	,	,
10_1101-2021_01_08_423993	104	41	20	20	CD
10_1101-2021_01_08_423993	104	42	U	u	NN
10_1101-2021_01_08_423993	104	43	;	;	:
10_1101-2021_01_08_423993	104	44	ThermoFisher	ThermoFisher	NNP
10_1101-2021_01_08_423993	104	45	Scientific	Scientific	NNP
10_1101-2021_01_08_423993	104	46	)	)	-RRB-
10_1101-2021_01_08_423993	104	47	,	,	,
10_1101-2021_01_08_423993	104	48	at	at	IN
10_1101-2021_01_08_423993	104	49	37oC	37oc	CD
10_1101-2021_01_08_423993	104	50	for	for	IN
10_1101-2021_01_08_423993	104	51	1	1	CD
10_1101-2021_01_08_423993	104	52	hour	hour	NN
10_1101-2021_01_08_423993	104	53	.	.	.
10_1101-2021_01_08_423993	105	1	This	this	DT
10_1101-2021_01_08_423993	105	2	solution	solution	NN
10_1101-2021_01_08_423993	105	3	was	be	VBD
10_1101-2021_01_08_423993	105	4	then	then	RB
10_1101-2021_01_08_423993	105	5	passed	pass	VBN
10_1101-2021_01_08_423993	105	6	through	through	IN
10_1101-2021_01_08_423993	105	7	a	a	DT
10_1101-2021_01_08_423993	105	8	P6	P6	NNP
10_1101-2021_01_08_423993	105	9	Micro	Micro	NNP
10_1101-2021_01_08_423993	105	10	Bio	Bio	NNP
10_1101-2021_01_08_423993	105	11	-	-	HYPH
10_1101-2021_01_08_423993	105	12	Spin	Spin	NNP
10_1101-2021_01_08_423993	105	13	chromatography	chromatography	NN
10_1101-2021_01_08_423993	105	14	column	column	NN
10_1101-2021_01_08_423993	105	15	(	(	-LRB-
10_1101-2021_01_08_423993	105	16	BioRad	BioRad	NNP
10_1101-2021_01_08_423993	105	17	)	)	-RRB-
10_1101-2021_01_08_423993	105	18	,	,	,
10_1101-2021_01_08_423993	105	19	and	and	CC
10_1101-2021_01_08_423993	105	20	the	the	DT
10_1101-2021_01_08_423993	105	21	radiolabeled	radiolabele	VBN
10_1101-2021_01_08_423993	105	22	DNA	DNA	NNP
10_1101-2021_01_08_423993	105	23	was	be	VBD
10_1101-2021_01_08_423993	105	24	annealed	anneal	VBN
10_1101-2021_01_08_423993	105	25	with	with	IN
10_1101-2021_01_08_423993	105	26	the	the	DT
10_1101-2021_01_08_423993	105	27	appropriate	appropriate	JJ
10_1101-2021_01_08_423993	105	28	unlabeled	unlabeled	JJ
10_1101-2021_01_08_423993	105	29	oligonucleotides	oligonucleotide	NNS
10_1101-2021_01_08_423993	105	30	(	(	-LRB-
10_1101-2021_01_08_423993	105	31	1:1.5	1:1.5	CD
10_1101-2021_01_08_423993	105	32	molar	molar	JJ
10_1101-2021_01_08_423993	105	33	ratio	ratio	NN
10_1101-2021_01_08_423993	105	34	of	of	IN
10_1101-2021_01_08_423993	105	35	labelled	label	VBN
10_1101-2021_01_08_423993	105	36	to	to	IN
10_1101-2021_01_08_423993	105	37	unlabeled	unlabeled	JJ
10_1101-2021_01_08_423993	105	38	oligonucleotide	oligonucleotide	NN
10_1101-2021_01_08_423993	105	39	)	)	-RRB-
10_1101-2021_01_08_423993	105	40	(	(	-LRB-
10_1101-2021_01_08_423993	105	41	Supplementary	Supplementary	NNP
10_1101-2021_01_08_423993	105	42	Table	Table	NNP
10_1101-2021_01_08_423993	105	43	1	1	CD
10_1101-2021_01_08_423993	105	44	for	for	IN
10_1101-2021_01_08_423993	105	45	sequences	sequence	NNS
10_1101-2021_01_08_423993	105	46	)	)	-RRB-
10_1101-2021_01_08_423993	105	47	by	by	IN
10_1101-2021_01_08_423993	105	48	heating	heat	VBG
10_1101-2021_01_08_423993	105	49	to	to	IN
10_1101-2021_01_08_423993	105	50	95oC	95oc	CD
10_1101-2021_01_08_423993	105	51	for	for	IN
10_1101-2021_01_08_423993	105	52	5	5	CD
10_1101-2021_01_08_423993	105	53	min	min	NN
10_1101-2021_01_08_423993	105	54	,	,	,
10_1101-2021_01_08_423993	105	55	and	and	CC
10_1101-2021_01_08_423993	105	56	cooling	cool	VBG
10_1101-2021_01_08_423993	105	57	to	to	IN
10_1101-2021_01_08_423993	105	58	below	below	IN
10_1101-2021_01_08_423993	105	59	30oC	30oc	CD
10_1101-2021_01_08_423993	105	60	in	in	IN
10_1101-2021_01_08_423993	105	61	annealing	anneal	VBG
10_1101-2021_01_08_423993	105	62	buffer	buffer	NN
10_1101-2021_01_08_423993	105	63	(	(	-LRB-
10_1101-2021_01_08_423993	105	64	10	10	CD
10_1101-2021_01_08_423993	105	65	mM	mM	NNP
10_1101-2021_01_08_423993	105	66	Tris	Tris	NNP
10_1101-2021_01_08_423993	105	67	-	-	HYPH
10_1101-2021_01_08_423993	105	68	HCl	HCl	NNP
10_1101-2021_01_08_423993	105	69	;	;	:
10_1101-2021_01_08_423993	105	70	pH	pH	NNP
10_1101-2021_01_08_423993	105	71	7.5	7.5	CD
10_1101-2021_01_08_423993	105	72	,	,	,
10_1101-2021_01_08_423993	105	73	100	100	CD
10_1101-2021_01_08_423993	105	74	mM	mM	NNP
10_1101-2021_01_08_423993	105	75	NaCl	NaCl	NNP
10_1101-2021_01_08_423993	105	76	,	,	,
10_1101-2021_01_08_423993	105	77	0.1	0.1	CD
10_1101-2021_01_08_423993	105	78	mM	mm	NN
10_1101-2021_01_08_423993	105	79	EDTA	edta	NN
10_1101-2021_01_08_423993	105	80	)	)	-RRB-
10_1101-2021_01_08_423993	105	81	.	.	.
10_1101-2021_01_08_423993	106	1	Gel	Gel	NNP
10_1101-2021_01_08_423993	106	2	-	-	HYPH
10_1101-2021_01_08_423993	106	3	based	base	VBN
10_1101-2021_01_08_423993	106	4	nuclease	nuclease	NN
10_1101-2021_01_08_423993	106	5	assays	assays	RB
10_1101-2021_01_08_423993	106	6	Standard	standard	JJ
10_1101-2021_01_08_423993	106	7	nuclease	nuclease	NN
10_1101-2021_01_08_423993	106	8	assays	assay	NNS
10_1101-2021_01_08_423993	106	9	were	be	VBD
10_1101-2021_01_08_423993	106	10	carried	carry	VBN
10_1101-2021_01_08_423993	106	11	out	out	RP
10_1101-2021_01_08_423993	106	12	in	in	IN
10_1101-2021_01_08_423993	106	13	reactions	reaction	NNS
10_1101-2021_01_08_423993	106	14	containing	contain	VBG
10_1101-2021_01_08_423993	106	15	20	20	CD
10_1101-2021_01_08_423993	106	16	mM	mM	NNP
10_1101-2021_01_08_423993	106	17	HEPES	HEPES	NNP
10_1101-2021_01_08_423993	106	18	-	-	HYPH
10_1101-2021_01_08_423993	106	19	KOH	KOH	NNP
10_1101-2021_01_08_423993	106	20	,	,	,
10_1101-2021_01_08_423993	106	21	pH	pH	NNP
10_1101-2021_01_08_423993	106	22	7.5	7.5	CD
10_1101-2021_01_08_423993	106	23	,	,	,
10_1101-2021_01_08_423993	106	24	50	50	CD
10_1101-2021_01_08_423993	106	25	mM	mm	NN
10_1101-2021_01_08_423993	106	26	KCl	KCl	NNS
10_1101-2021_01_08_423993	106	27	,	,	,
10_1101-2021_01_08_423993	106	28	10	10	CD
10_1101-2021_01_08_423993	106	29	mM	mM	NNP
10_1101-2021_01_08_423993	106	30	MgCl2	mgcl2	NN
10_1101-2021_01_08_423993	106	31	,	,	,
10_1101-2021_01_08_423993	106	32	0.05	0.05	CD
10_1101-2021_01_08_423993	106	33	%	%	NN
10_1101-2021_01_08_423993	106	34	(	(	-LRB-
10_1101-2021_01_08_423993	106	35	v	v	NN
10_1101-2021_01_08_423993	106	36	/	/	SYM
10_1101-2021_01_08_423993	106	37	v	v	LS
10_1101-2021_01_08_423993	106	38	)	)	-RRB-
10_1101-2021_01_08_423993	106	39	Triton	Triton	NNP
10_1101-2021_01_08_423993	106	40	X-100	X-100	NNP
10_1101-2021_01_08_423993	106	41	,	,	,
10_1101-2021_01_08_423993	106	42	5	5	CD
10_1101-2021_01_08_423993	106	43	%	%	NN
10_1101-2021_01_08_423993	106	44	(	(	-LRB-
10_1101-2021_01_08_423993	106	45	v	v	NN
10_1101-2021_01_08_423993	106	46	/	/	SYM
10_1101-2021_01_08_423993	106	47	v	v	NN
10_1101-2021_01_08_423993	106	48	)	)	-RRB-
10_1101-2021_01_08_423993	106	49	glycerol	glycerol	NN
10_1101-2021_01_08_423993	106	50	(	(	-LRB-
10_1101-2021_01_08_423993	106	51	final	final	JJ
10_1101-2021_01_08_423993	106	52	volume	volume	NN
10_1101-2021_01_08_423993	106	53	:	:	:
10_1101-2021_01_08_423993	106	54	.CC	.CC	:
10_1101-2021_01_08_423993	106	55	-	-	:
10_1101-2021_01_08_423993	106	56	BY	by	IN
10_1101-2021_01_08_423993	106	57	4.0	4.0	CD
10_1101-2021_01_08_423993	106	58	International	international	JJ
10_1101-2021_01_08_423993	106	59	licensemade	licensemade	NN
10_1101-2021_01_08_423993	106	60	available	available	JJ
10_1101-2021_01_08_423993	106	61	under	under	IN
10_1101-2021_01_08_423993	106	62	a	a	DT
10_1101-2021_01_08_423993	106	63	(	(	-LRB-
10_1101-2021_01_08_423993	106	64	which	which	WDT
10_1101-2021_01_08_423993	106	65	was	be	VBD
10_1101-2021_01_08_423993	106	66	not	not	RB
10_1101-2021_01_08_423993	106	67	certified	certify	VBN
10_1101-2021_01_08_423993	106	68	by	by	IN
10_1101-2021_01_08_423993	106	69	peer	peer	NN
10_1101-2021_01_08_423993	106	70	review	review	NN
10_1101-2021_01_08_423993	106	71	)	)	-RRB-
10_1101-2021_01_08_423993	106	72	is	be	VBZ
10_1101-2021_01_08_423993	106	73	the	the	DT
10_1101-2021_01_08_423993	106	74	author	author	NN
10_1101-2021_01_08_423993	106	75	/	/	SYM
10_1101-2021_01_08_423993	106	76	funder	funder	NN
10_1101-2021_01_08_423993	106	77	,	,	,
10_1101-2021_01_08_423993	106	78	who	who	WP
10_1101-2021_01_08_423993	106	79	has	have	VBZ
10_1101-2021_01_08_423993	106	80	granted	grant	VBN
10_1101-2021_01_08_423993	106	81	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	106	82	a	a	DT
10_1101-2021_01_08_423993	106	83	license	license	NN
10_1101-2021_01_08_423993	106	84	to	to	TO
10_1101-2021_01_08_423993	106	85	display	display	VB
10_1101-2021_01_08_423993	106	86	the	the	DT
10_1101-2021_01_08_423993	106	87	preprint	preprint	NN
10_1101-2021_01_08_423993	106	88	in	in	IN
10_1101-2021_01_08_423993	106	89	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	106	90	.	.	.
10_1101-2021_01_08_423993	107	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	107	2	is	be	VBZ
10_1101-2021_01_08_423993	107	3	The	the	DT
10_1101-2021_01_08_423993	107	4	copyright	copyright	NN
10_1101-2021_01_08_423993	107	5	holder	holder	NN
10_1101-2021_01_08_423993	107	6	for	for	IN
10_1101-2021_01_08_423993	107	7	this	this	DT
10_1101-2021_01_08_423993	107	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	107	9	version	version	NN
10_1101-2021_01_08_423993	107	10	posted	post	VBD
10_1101-2021_01_08_423993	107	11	January	January	NNP
10_1101-2021_01_08_423993	107	12	8	8	CD
10_1101-2021_01_08_423993	107	13	,	,	,
10_1101-2021_01_08_423993	107	14	2021	2021	CD
10_1101-2021_01_08_423993	107	15	.	.	.
10_1101-2021_01_08_423993	107	16	;	;	:
10_1101-2021_01_08_423993	107	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	107	18	:	:	:
10_1101-2021_01_08_423993	107	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	107	20	preprint	preprint	NN
10_1101-2021_01_08_423993	107	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	CD
10_1101-2021_01_08_423993	107	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	107	23	10	10	CD
10_1101-2021_01_08_423993	107	24	μL	μL	NNP
10_1101-2021_01_08_423993	107	25	)	)	-RRB-
10_1101-2021_01_08_423993	107	26	,	,	,
10_1101-2021_01_08_423993	107	27	and	and	CC
10_1101-2021_01_08_423993	107	28	the	the	DT
10_1101-2021_01_08_423993	107	29	indicated	indicate	VBN
10_1101-2021_01_08_423993	107	30	concentrations	concentration	NNS
10_1101-2021_01_08_423993	107	31	of	of	IN
10_1101-2021_01_08_423993	107	32	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	107	33	.	.	.
10_1101-2021_01_08_423993	108	1	Reactions	reaction	NNS
10_1101-2021_01_08_423993	108	2	were	be	VBD
10_1101-2021_01_08_423993	108	3	started	start	VBN
10_1101-2021_01_08_423993	108	4	by	by	IN
10_1101-2021_01_08_423993	108	5	the	the	DT
10_1101-2021_01_08_423993	108	6	addition	addition	NN
10_1101-2021_01_08_423993	108	7	of	of	IN
10_1101-2021_01_08_423993	108	8	DNA	DNA	NNP
10_1101-2021_01_08_423993	108	9	substrate	substrate	NN
10_1101-2021_01_08_423993	108	10	(	(	-LRB-
10_1101-2021_01_08_423993	108	11	10	10	CD
10_1101-2021_01_08_423993	108	12	nM	nM	NNP
10_1101-2021_01_08_423993	108	13	)	)	-RRB-
10_1101-2021_01_08_423993	108	14	,	,	,
10_1101-2021_01_08_423993	108	15	incubated	incubate	VBD
10_1101-2021_01_08_423993	108	16	at	at	IN
10_1101-2021_01_08_423993	108	17	37	37	CD
10_1101-2021_01_08_423993	108	18	°	°	,
10_1101-2021_01_08_423993	108	19	C	C	NNP
10_1101-2021_01_08_423993	108	20	for	for	IN
10_1101-2021_01_08_423993	108	21	the	the	DT
10_1101-2021_01_08_423993	108	22	indicated	indicate	VBN
10_1101-2021_01_08_423993	108	23	time	time	NN
10_1101-2021_01_08_423993	108	24	,	,	,
10_1101-2021_01_08_423993	108	25	then	then	RB
10_1101-2021_01_08_423993	108	26	quenched	quench	VBN
10_1101-2021_01_08_423993	108	27	by	by	IN
10_1101-2021_01_08_423993	108	28	addition	addition	NN
10_1101-2021_01_08_423993	108	29	of	of	IN
10_1101-2021_01_08_423993	108	30	10	10	CD
10_1101-2021_01_08_423993	108	31	μL	μl	NN
10_1101-2021_01_08_423993	108	32	stop	stop	VB
10_1101-2021_01_08_423993	108	33	solution	solution	NN
10_1101-2021_01_08_423993	108	34	(	(	-LRB-
10_1101-2021_01_08_423993	108	35	95	95	CD
10_1101-2021_01_08_423993	108	36	%	%	NN
10_1101-2021_01_08_423993	108	37	formamide	formamide	NN
10_1101-2021_01_08_423993	108	38	,	,	,
10_1101-2021_01_08_423993	108	39	10	10	CD
10_1101-2021_01_08_423993	108	40	mM	mm	NN
10_1101-2021_01_08_423993	108	41	EDTA	edta	NN
10_1101-2021_01_08_423993	108	42	,	,	,
10_1101-2021_01_08_423993	108	43	0.25	0.25	CD
10_1101-2021_01_08_423993	108	44	%	%	NN
10_1101-2021_01_08_423993	108	45	(	(	-LRB-
10_1101-2021_01_08_423993	108	46	v	v	NN
10_1101-2021_01_08_423993	108	47	/	/	SYM
10_1101-2021_01_08_423993	108	48	v	v	NNP
10_1101-2021_01_08_423993	108	49	)	)	-RRB-
10_1101-2021_01_08_423993	108	50	xylene	xylene	NNP
10_1101-2021_01_08_423993	108	51	cyanole	cyanole	NNP
10_1101-2021_01_08_423993	108	52	,	,	,
10_1101-2021_01_08_423993	108	53	0.25	0.25	CD
10_1101-2021_01_08_423993	108	54	%	%	NN
10_1101-2021_01_08_423993	108	55	(	(	-LRB-
10_1101-2021_01_08_423993	108	56	v	v	NN
10_1101-2021_01_08_423993	108	57	/	/	SYM
10_1101-2021_01_08_423993	108	58	v	v	NN
10_1101-2021_01_08_423993	108	59	)	)	-RRB-
10_1101-2021_01_08_423993	108	60	bromophenol	bromophenol	NN
10_1101-2021_01_08_423993	108	61	blue	blue	JJ
10_1101-2021_01_08_423993	108	62	)	)	-RRB-
10_1101-2021_01_08_423993	108	63	with	with	IN
10_1101-2021_01_08_423993	108	64	incubation	incubation	NN
10_1101-2021_01_08_423993	108	65	at	at	IN
10_1101-2021_01_08_423993	108	66	95	95	CD
10_1101-2021_01_08_423993	108	67	°	°	,
10_1101-2021_01_08_423993	108	68	C	C	NNP
10_1101-2021_01_08_423993	108	69	for	for	IN
10_1101-2021_01_08_423993	108	70	3	3	CD
10_1101-2021_01_08_423993	108	71	min	min	NN
10_1101-2021_01_08_423993	108	72	.	.	.
10_1101-2021_01_08_423993	109	1	Reaction	reaction	NN
10_1101-2021_01_08_423993	109	2	products	product	NNS
10_1101-2021_01_08_423993	109	3	were	be	VBD
10_1101-2021_01_08_423993	109	4	analysed	analyse	VBN
10_1101-2021_01_08_423993	109	5	by	by	IN
10_1101-2021_01_08_423993	109	6	20	20	CD
10_1101-2021_01_08_423993	109	7	%	%	NN
10_1101-2021_01_08_423993	109	8	denaturing	denature	VBG
10_1101-2021_01_08_423993	109	9	polyacrylamide	polyacrylamide	NN
10_1101-2021_01_08_423993	109	10	gel	gel	NN
10_1101-2021_01_08_423993	109	11	electrophoresis	electrophoresis	NN
10_1101-2021_01_08_423993	109	12	(	(	-LRB-
10_1101-2021_01_08_423993	109	13	made	make	VBN
10_1101-2021_01_08_423993	109	14	from	from	IN
10_1101-2021_01_08_423993	109	15	40	40	CD
10_1101-2021_01_08_423993	109	16	%	%	NN
10_1101-2021_01_08_423993	109	17	solution	solution	NN
10_1101-2021_01_08_423993	109	18	of	of	IN
10_1101-2021_01_08_423993	109	19	19:1	19:1	CD
10_1101-2021_01_08_423993	109	20	acrylamide	acrylamide	NN
10_1101-2021_01_08_423993	109	21	:	:	:
10_1101-2021_01_08_423993	109	22	bis	bis	NN
10_1101-2021_01_08_423993	109	23	-	-	HYPH
10_1101-2021_01_08_423993	109	24	acrylamide	acrylamide	NN
10_1101-2021_01_08_423993	109	25	,	,	,
10_1101-2021_01_08_423993	109	26	BioRad	BioRad	NNP
10_1101-2021_01_08_423993	109	27	)	)	-RRB-
10_1101-2021_01_08_423993	109	28	and	and	CC
10_1101-2021_01_08_423993	109	29	7	7	CD
10_1101-2021_01_08_423993	109	30	M	M	NNP
10_1101-2021_01_08_423993	109	31	urea	urea	NN
10_1101-2021_01_08_423993	109	32	(	(	-LRB-
10_1101-2021_01_08_423993	109	33	Sigma	Sigma	NNP
10_1101-2021_01_08_423993	109	34	Aldrich	Aldrich	NNP
10_1101-2021_01_08_423993	109	35	)	)	-RRB-
10_1101-2021_01_08_423993	109	36	)	)	-RRB-
10_1101-2021_01_08_423993	109	37	in	in	IN
10_1101-2021_01_08_423993	109	38	1	1	CD
10_1101-2021_01_08_423993	109	39	x	x	SYM
10_1101-2021_01_08_423993	109	40	TBE	TBE	NNP
10_1101-2021_01_08_423993	109	41	(	(	-LRB-
10_1101-2021_01_08_423993	109	42	Tris	Tris	NNP
10_1101-2021_01_08_423993	109	43	-	-	HYPH
10_1101-2021_01_08_423993	109	44	borate	borate	NNP
10_1101-2021_01_08_423993	109	45	EDTA	EDTA	NNP
10_1101-2021_01_08_423993	109	46	)	)	-RRB-
10_1101-2021_01_08_423993	109	47	buffer	buffer	NN
10_1101-2021_01_08_423993	109	48	.	.	.
10_1101-2021_01_08_423993	110	1	Electrophoresis	electrophoresis	NN
10_1101-2021_01_08_423993	110	2	was	be	VBD
10_1101-2021_01_08_423993	110	3	carried	carry	VBN
10_1101-2021_01_08_423993	110	4	out	out	RP
10_1101-2021_01_08_423993	110	5	at	at	IN
10_1101-2021_01_08_423993	110	6	700	700	CD
10_1101-2021_01_08_423993	110	7	V	v	NN
10_1101-2021_01_08_423993	110	8	for	for	IN
10_1101-2021_01_08_423993	110	9	75	75	CD
10_1101-2021_01_08_423993	110	10	minutes	minute	NNS
10_1101-2021_01_08_423993	110	11	;	;	:
10_1101-2021_01_08_423993	110	12	gels	gel	NNS
10_1101-2021_01_08_423993	110	13	were	be	VBD
10_1101-2021_01_08_423993	110	14	subsequently	subsequently	RB
10_1101-2021_01_08_423993	110	15	fixed	fix	VBN
10_1101-2021_01_08_423993	110	16	for	for	IN
10_1101-2021_01_08_423993	110	17	40	40	CD
10_1101-2021_01_08_423993	110	18	minutes	minute	NNS
10_1101-2021_01_08_423993	110	19	in	in	IN
10_1101-2021_01_08_423993	110	20	a	a	DT
10_1101-2021_01_08_423993	110	21	50	50	CD
10_1101-2021_01_08_423993	110	22	%	%	NN
10_1101-2021_01_08_423993	110	23	methanol	methanol	NN
10_1101-2021_01_08_423993	110	24	,	,	,
10_1101-2021_01_08_423993	110	25	10	10	CD
10_1101-2021_01_08_423993	110	26	%	%	NN
10_1101-2021_01_08_423993	110	27	acetic	acetic	JJ
10_1101-2021_01_08_423993	110	28	acid	acid	NN
10_1101-2021_01_08_423993	110	29	solution	solution	NN
10_1101-2021_01_08_423993	110	30	,	,	,
10_1101-2021_01_08_423993	110	31	and	and	CC
10_1101-2021_01_08_423993	110	32	dried	dry	VBD
10_1101-2021_01_08_423993	110	33	at	at	IN
10_1101-2021_01_08_423993	110	34	80	80	CD
10_1101-2021_01_08_423993	110	35	°	°	,
10_1101-2021_01_08_423993	110	36	C	C	NNP
10_1101-2021_01_08_423993	110	37	for	for	IN
10_1101-2021_01_08_423993	110	38	two	two	CD
10_1101-2021_01_08_423993	110	39	hours	hour	NNS
10_1101-2021_01_08_423993	110	40	under	under	IN
10_1101-2021_01_08_423993	110	41	a	a	DT
10_1101-2021_01_08_423993	110	42	vacuum	vacuum	NN
10_1101-2021_01_08_423993	110	43	.	.	.
10_1101-2021_01_08_423993	111	1	Dried	dry	VBN
10_1101-2021_01_08_423993	111	2	gels	gel	NNS
10_1101-2021_01_08_423993	111	3	were	be	VBD
10_1101-2021_01_08_423993	111	4	exposed	expose	VBN
10_1101-2021_01_08_423993	111	5	to	to	IN
10_1101-2021_01_08_423993	111	6	a	a	DT
10_1101-2021_01_08_423993	111	7	Kodak	Kodak	NNP
10_1101-2021_01_08_423993	111	8	phosphor	phosphor	NN
10_1101-2021_01_08_423993	111	9	imager	imager	NN
10_1101-2021_01_08_423993	111	10	screen	screen	NN
10_1101-2021_01_08_423993	111	11	and	and	CC
10_1101-2021_01_08_423993	111	12	scanned	scan	VBD
10_1101-2021_01_08_423993	111	13	using	use	VBG
10_1101-2021_01_08_423993	111	14	a	a	DT
10_1101-2021_01_08_423993	111	15	Typhoon	Typhoon	NNP
10_1101-2021_01_08_423993	111	16	9500	9500	CD
10_1101-2021_01_08_423993	111	17	instrument	instrument	NN
10_1101-2021_01_08_423993	111	18	(	(	-LRB-
10_1101-2021_01_08_423993	111	19	GE	GE	NNP
10_1101-2021_01_08_423993	111	20	)	)	-RRB-
10_1101-2021_01_08_423993	111	21	.	.	.
10_1101-2021_01_08_423993	112	1	Fluorescence	Fluorescence	NNP
10_1101-2021_01_08_423993	112	2	-	-	HYPH
10_1101-2021_01_08_423993	112	3	based	base	VBN
10_1101-2021_01_08_423993	112	4	nuclease	nuclease	NNP
10_1101-2021_01_08_423993	112	5	assay	assay	NN
10_1101-2021_01_08_423993	112	6	.	.	.
10_1101-2021_01_08_423993	113	1	The	the	DT
10_1101-2021_01_08_423993	113	2	protocol	protocol	NN
10_1101-2021_01_08_423993	113	3	of	of	IN
10_1101-2021_01_08_423993	113	4	Lee	Lee	NNP
10_1101-2021_01_08_423993	113	5	et	et	NNP
10_1101-2021_01_08_423993	113	6	al	al	NNP
10_1101-2021_01_08_423993	113	7	[	[	-LRB-
10_1101-2021_01_08_423993	113	8	41	41	CD
10_1101-2021_01_08_423993	113	9	]	]	-RRB-
10_1101-2021_01_08_423993	113	10	was	be	VBD
10_1101-2021_01_08_423993	113	11	adapted	adapt	VBN
10_1101-2021_01_08_423993	113	12	for	for	IN
10_1101-2021_01_08_423993	113	13	structure	structure	NN
10_1101-2021_01_08_423993	113	14	-	-	HYPH
10_1101-2021_01_08_423993	113	15	specific	specific	JJ
10_1101-2021_01_08_423993	113	16	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	113	17	activity	activity	NN
10_1101-2021_01_08_423993	113	18	.	.	.
10_1101-2021_01_08_423993	114	1	A	a	DT
10_1101-2021_01_08_423993	114	2	ssDNA	ssdna	CD
10_1101-2021_01_08_423993	114	3	substrate	substrate	NN
10_1101-2021_01_08_423993	114	4	was	be	VBD
10_1101-2021_01_08_423993	114	5	utilised	utilise	VBN
10_1101-2021_01_08_423993	114	6	containing	contain	VBG
10_1101-2021_01_08_423993	114	7	a	a	DT
10_1101-2021_01_08_423993	114	8	5	5	CD
10_1101-2021_01_08_423993	114	9	’	'	''
10_1101-2021_01_08_423993	114	10	FITC	fitc	RB
10_1101-2021_01_08_423993	114	11	-	-	HYPH
10_1101-2021_01_08_423993	114	12	conjugated	conjugate	VBN
10_1101-2021_01_08_423993	114	13	T	T	NNP
10_1101-2021_01_08_423993	114	14	and	and	CC
10_1101-2021_01_08_423993	114	15	a	a	DT
10_1101-2021_01_08_423993	114	16	3	3	CD
10_1101-2021_01_08_423993	114	17	’	'	''
10_1101-2021_01_08_423993	114	18	BHQ-1	bhq-1	JJ
10_1101-2021_01_08_423993	114	19	(	(	-LRB-
10_1101-2021_01_08_423993	114	20	black	black	JJ
10_1101-2021_01_08_423993	114	21	hole	hole	NN
10_1101-2021_01_08_423993	114	22	quencher)-conjugated	quencher)-conjugated	NNP
10_1101-2021_01_08_423993	114	23	T	T	NNP
10_1101-2021_01_08_423993	114	24	(	(	-LRB-
10_1101-2021_01_08_423993	114	25	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	114	26	.	.	.
10_1101-2021_01_08_423993	115	1	Table	table	NN
10_1101-2021_01_08_423993	115	2	1	1	CD
10_1101-2021_01_08_423993	115	3	)	)	-RRB-
10_1101-2021_01_08_423993	115	4	.	.	.
10_1101-2021_01_08_423993	116	1	As	as	IN
10_1101-2021_01_08_423993	116	2	the	the	DT
10_1101-2021_01_08_423993	116	3	FITC	FITC	NNP
10_1101-2021_01_08_423993	116	4	and	and	CC
10_1101-2021_01_08_423993	116	5	BHQ-1	BHQ-1	NNP
10_1101-2021_01_08_423993	116	6	are	be	VBP
10_1101-2021_01_08_423993	116	7	located	locate	VBN
10_1101-2021_01_08_423993	116	8	proximal	proximal	JJ
10_1101-2021_01_08_423993	116	9	to	to	IN
10_1101-2021_01_08_423993	116	10	one	one	CD
10_1101-2021_01_08_423993	116	11	another	another	DT
10_1101-2021_01_08_423993	116	12	,	,	,
10_1101-2021_01_08_423993	116	13	prior	prior	RB
10_1101-2021_01_08_423993	116	14	to	to	IN
10_1101-2021_01_08_423993	116	15	endonucleolytic	endonucleolytic	JJ
10_1101-2021_01_08_423993	116	16	incision	incision	NN
10_1101-2021_01_08_423993	116	17	,	,	,
10_1101-2021_01_08_423993	116	18	the	the	DT
10_1101-2021_01_08_423993	116	19	intact	intact	JJ
10_1101-2021_01_08_423993	116	20	substrate	substrate	NN
10_1101-2021_01_08_423993	116	21	does	do	VBZ
10_1101-2021_01_08_423993	116	22	not	not	RB
10_1101-2021_01_08_423993	116	23	fluoresce	fluoresce	VB
10_1101-2021_01_08_423993	116	24	.	.	.
10_1101-2021_01_08_423993	117	1	Following	follow	VBG
10_1101-2021_01_08_423993	117	2	endonucleolytic	endonucleolytic	JJ
10_1101-2021_01_08_423993	117	3	incision	incision	NN
10_1101-2021_01_08_423993	117	4	by	by	IN
10_1101-2021_01_08_423993	117	5	DCLRE1C	DCLRE1C	NNP
10_1101-2021_01_08_423993	117	6	/	/	SYM
10_1101-2021_01_08_423993	117	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	117	8	,	,	,
10_1101-2021_01_08_423993	117	9	there	there	EX
10_1101-2021_01_08_423993	117	10	is	be	VBZ
10_1101-2021_01_08_423993	117	11	uncoupling	uncoupling	JJ
10_1101-2021_01_08_423993	117	12	of	of	IN
10_1101-2021_01_08_423993	117	13	the	the	DT
10_1101-2021_01_08_423993	117	14	FITC	FITC	NNP
10_1101-2021_01_08_423993	117	15	from	from	IN
10_1101-2021_01_08_423993	117	16	the	the	DT
10_1101-2021_01_08_423993	117	17	BHQ-1	BHQ-1	NNP
10_1101-2021_01_08_423993	117	18	and	and	CC
10_1101-2021_01_08_423993	117	19	an	an	DT
10_1101-2021_01_08_423993	117	20	increase	increase	NN
10_1101-2021_01_08_423993	117	21	in	in	IN
10_1101-2021_01_08_423993	117	22	fluorescence	fluorescence	NN
10_1101-2021_01_08_423993	117	23	.	.	.
10_1101-2021_01_08_423993	118	1	Inhibitors	inhibitor	NNS
10_1101-2021_01_08_423993	118	2	(	(	-LRB-
10_1101-2021_01_08_423993	118	3	at	at	IN
10_1101-2021_01_08_423993	118	4	increasing	increase	VBG
10_1101-2021_01_08_423993	118	5	concentrations	concentration	NNS
10_1101-2021_01_08_423993	118	6	)	)	-RRB-
10_1101-2021_01_08_423993	118	7	were	be	VBD
10_1101-2021_01_08_423993	118	8	incubated	incubate	VBN
10_1101-2021_01_08_423993	118	9	with	with	IN
10_1101-2021_01_08_423993	118	10	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	118	11	for	for	IN
10_1101-2021_01_08_423993	118	12	10	10	CD
10_1101-2021_01_08_423993	118	13	minutes	minute	NNS
10_1101-2021_01_08_423993	118	14	at	at	IN
10_1101-2021_01_08_423993	118	15	room	room	NN
10_1101-2021_01_08_423993	118	16	temperature	temperature	NN
10_1101-2021_01_08_423993	118	17	,	,	,
10_1101-2021_01_08_423993	118	18	before	before	IN
10_1101-2021_01_08_423993	118	19	the	the	DT
10_1101-2021_01_08_423993	118	20	reaction	reaction	NN
10_1101-2021_01_08_423993	118	21	was	be	VBD
10_1101-2021_01_08_423993	118	22	started	start	VBN
10_1101-2021_01_08_423993	118	23	with	with	IN
10_1101-2021_01_08_423993	118	24	the	the	DT
10_1101-2021_01_08_423993	118	25	addition	addition	NN
10_1101-2021_01_08_423993	118	26	of	of	IN
10_1101-2021_01_08_423993	118	27	DNA	DNA	NNP
10_1101-2021_01_08_423993	118	28	substrate	substrate	NN
10_1101-2021_01_08_423993	118	29	.	.	.
10_1101-2021_01_08_423993	119	1	Assays	assay	NNS
10_1101-2021_01_08_423993	119	2	were	be	VBD
10_1101-2021_01_08_423993	119	3	carried	carry	VBN
10_1101-2021_01_08_423993	119	4	out	out	RP
10_1101-2021_01_08_423993	119	5	in	in	IN
10_1101-2021_01_08_423993	119	6	a	a	DT
10_1101-2021_01_08_423993	119	7	384-well	384-well	CD
10_1101-2021_01_08_423993	119	8	format	format	NN
10_1101-2021_01_08_423993	119	9	,	,	,
10_1101-2021_01_08_423993	119	10	in	in	IN
10_1101-2021_01_08_423993	119	11	a	a	DT
10_1101-2021_01_08_423993	119	12	25	25	CD
10_1101-2021_01_08_423993	119	13	L	L	NNP
10_1101-2021_01_08_423993	119	14	reaction	reaction	NN
10_1101-2021_01_08_423993	119	15	volume	volume	NN
10_1101-2021_01_08_423993	119	16	.	.	.
10_1101-2021_01_08_423993	120	1	The	the	DT
10_1101-2021_01_08_423993	120	2	buffer	buffer	NN
10_1101-2021_01_08_423993	120	3	was	be	VBD
10_1101-2021_01_08_423993	120	4	the	the	DT
10_1101-2021_01_08_423993	120	5	same	same	JJ
10_1101-2021_01_08_423993	120	6	as	as	IN
10_1101-2021_01_08_423993	120	7	for	for	IN
10_1101-2021_01_08_423993	120	8	the	the	DT
10_1101-2021_01_08_423993	120	9	gel	gel	NN
10_1101-2021_01_08_423993	120	10	-	-	HYPH
10_1101-2021_01_08_423993	120	11	based	base	VBN
10_1101-2021_01_08_423993	120	12	nuclease	nuclease	NN
10_1101-2021_01_08_423993	120	13	assays	assays	RB
10_1101-2021_01_08_423993	120	14	,	,	,
10_1101-2021_01_08_423993	120	15	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	120	16	concentration	concentration	NN
10_1101-2021_01_08_423993	120	17	was	be	VBD
10_1101-2021_01_08_423993	120	18	50	50	CD
10_1101-2021_01_08_423993	120	19	nM	nM	NNP
10_1101-2021_01_08_423993	120	20	,	,	,
10_1101-2021_01_08_423993	120	21	and	and	CC
10_1101-2021_01_08_423993	120	22	the	the	DT
10_1101-2021_01_08_423993	120	23	DNA	DNA	NNP
10_1101-2021_01_08_423993	120	24	substrate	substrate	NN
10_1101-2021_01_08_423993	120	25	was	be	VBD
10_1101-2021_01_08_423993	120	26	at	at	IN
10_1101-2021_01_08_423993	120	27	25	25	CD
10_1101-2021_01_08_423993	120	28	nM.	nm.	NN
10_1101-2021_01_08_423993	121	1	Fluorescence	Fluorescence	NNP
10_1101-2021_01_08_423993	121	2	spectra	spectra	NN
10_1101-2021_01_08_423993	121	3	were	be	VBD
10_1101-2021_01_08_423993	121	4	measured	measure	VBN
10_1101-2021_01_08_423993	121	5	using	use	VBG
10_1101-2021_01_08_423993	121	6	a	a	DT
10_1101-2021_01_08_423993	121	7	PHERAstar	PHERAstar	NNP
10_1101-2021_01_08_423993	121	8	FSX	FSX	NNP
10_1101-2021_01_08_423993	121	9	(	(	-LRB-
10_1101-2021_01_08_423993	121	10	excitation	excitation	NN
10_1101-2021_01_08_423993	121	11	:	:	:
10_1101-2021_01_08_423993	121	12	495	495	CD
10_1101-2021_01_08_423993	121	13	nm	nm	NN
10_1101-2021_01_08_423993	121	14	;	;	:
10_1101-2021_01_08_423993	121	15	emission	emission	NN
10_1101-2021_01_08_423993	121	16	:	:	:
10_1101-2021_01_08_423993	121	17	525	525	CD
10_1101-2021_01_08_423993	121	18	nm	nm	CD
10_1101-2021_01_08_423993	121	19	)	)	-RRB-
10_1101-2021_01_08_423993	121	20	with	with	IN
10_1101-2021_01_08_423993	121	21	readings	reading	NNS
10_1101-2021_01_08_423993	121	22	taken	take	VBN
10_1101-2021_01_08_423993	121	23	every	every	DT
10_1101-2021_01_08_423993	121	24	150	150	CD
10_1101-2021_01_08_423993	121	25	sec	sec	NNP
10_1101-2021_01_08_423993	121	26	,	,	,
10_1101-2021_01_08_423993	121	27	for	for	IN
10_1101-2021_01_08_423993	121	28	35	35	CD
10_1101-2021_01_08_423993	121	29	min	min	NN
10_1101-2021_01_08_423993	121	30	,	,	,
10_1101-2021_01_08_423993	121	31	at	at	IN
10_1101-2021_01_08_423993	121	32	37	37	CD
10_1101-2021_01_08_423993	121	33	°	°	NNS
10_1101-2021_01_08_423993	121	34	C	C	NNP
10_1101-2021_01_08_423993	121	35	.	.	.
10_1101-2021_01_08_423993	122	1	RESULTS	RESULTS	NNP
10_1101-2021_01_08_423993	122	2	Human	Human	NNP
10_1101-2021_01_08_423993	122	3	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	122	4	(	(	-LRB-
10_1101-2021_01_08_423993	122	5	SNM1C	snm1c	CD
10_1101-2021_01_08_423993	122	6	or	or	CC
10_1101-2021_01_08_423993	122	7	DCLRE1C	dclre1c	UH
10_1101-2021_01_08_423993	122	8	)	)	-RRB-
10_1101-2021_01_08_423993	122	9	has	have	VBZ
10_1101-2021_01_08_423993	122	10	a	a	DT
10_1101-2021_01_08_423993	122	11	core	core	NN
10_1101-2021_01_08_423993	122	12	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	122	13	fold	fold	NN
10_1101-2021_01_08_423993	122	14	similar	similar	JJ
10_1101-2021_01_08_423993	122	15	to	to	IN
10_1101-2021_01_08_423993	122	16	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	122	17	and	and	CC
10_1101-2021_01_08_423993	122	18	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	122	19	/	/	SYM
10_1101-2021_01_08_423993	122	20	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	122	21	The	the	DT
10_1101-2021_01_08_423993	122	22	core	core	JJ
10_1101-2021_01_08_423993	122	23	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	122	24	domain	domain	NN
10_1101-2021_01_08_423993	122	25	of	of	IN
10_1101-2021_01_08_423993	122	26	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	122	27	(	(	-LRB-
10_1101-2021_01_08_423993	122	28	aa	aa	NNP
10_1101-2021_01_08_423993	122	29	3–361	3–361	NNP
10_1101-2021_01_08_423993	122	30	)	)	-RRB-
10_1101-2021_01_08_423993	122	31	was	be	VBD
10_1101-2021_01_08_423993	122	32	produced	produce	VBN
10_1101-2021_01_08_423993	122	33	in	in	IN
10_1101-2021_01_08_423993	122	34	baculovirus	baculovirus	NNP
10_1101-2021_01_08_423993	122	35	-	-	HYPH
10_1101-2021_01_08_423993	122	36	infected	infect	VBN
10_1101-2021_01_08_423993	122	37	Sf9	sf9	JJ
10_1101-2021_01_08_423993	122	38	cells	cell	NNS
10_1101-2021_01_08_423993	122	39	fused	fuse	VBN
10_1101-2021_01_08_423993	122	40	to	to	IN
10_1101-2021_01_08_423993	122	41	a	a	DT
10_1101-2021_01_08_423993	122	42	highly	highly	RB
10_1101-2021_01_08_423993	122	43	basic	basic	JJ
10_1101-2021_01_08_423993	122	44	His6-Zb	His6-Zb	NNP
10_1101-2021_01_08_423993	122	45	tag	tag	NN
10_1101-2021_01_08_423993	122	46	,	,	,
10_1101-2021_01_08_423993	122	47	which	which	WDT
10_1101-2021_01_08_423993	122	48	confers	confer	VBZ
10_1101-2021_01_08_423993	122	49	tight	tight	RB
10_1101-2021_01_08_423993	122	50	binding	bind	VBG
10_1101-2021_01_08_423993	122	51	to	to	IN
10_1101-2021_01_08_423993	122	52	cation	cation	NN
10_1101-2021_01_08_423993	122	53	exchange	exchange	NN
10_1101-2021_01_08_423993	122	54	columns	column	NNS
10_1101-2021_01_08_423993	122	55	.	.	.
10_1101-2021_01_08_423993	123	1	The	the	DT
10_1101-2021_01_08_423993	123	2	protein	protein	NN
10_1101-2021_01_08_423993	123	3	was	be	VBD
10_1101-2021_01_08_423993	123	4	purified	purify	VBN
10_1101-2021_01_08_423993	123	5	using	use	VBG
10_1101-2021_01_08_423993	123	6	immobilised	immobilise	VBN
10_1101-2021_01_08_423993	123	7	metal	metal	NN
10_1101-2021_01_08_423993	123	8	affinity	affinity	NN
10_1101-2021_01_08_423993	123	9	chromatography	chromatography	NN
10_1101-2021_01_08_423993	123	10	(	(	-LRB-
10_1101-2021_01_08_423993	123	11	IMAC	IMAC	NNP
10_1101-2021_01_08_423993	123	12	)	)	-RRB-
10_1101-2021_01_08_423993	123	13	on	on	IN
10_1101-2021_01_08_423993	123	14	a	a	DT
10_1101-2021_01_08_423993	123	15	Nickel	Nickel	NNP
10_1101-2021_01_08_423993	123	16	-	-	HYPH
10_1101-2021_01_08_423993	123	17	Sepharose	sepharose	NN
10_1101-2021_01_08_423993	123	18	column	column	NN
10_1101-2021_01_08_423993	123	19	as	as	IN
10_1101-2021_01_08_423993	123	20	the	the	DT
10_1101-2021_01_08_423993	123	21	initial	initial	JJ
10_1101-2021_01_08_423993	123	22	step	step	NN
10_1101-2021_01_08_423993	123	23	.	.	.
10_1101-2021_01_08_423993	124	1	Subsequent	subsequent	JJ
10_1101-2021_01_08_423993	124	2	preparations	preparation	NNS
10_1101-2021_01_08_423993	124	3	were	be	VBD
10_1101-2021_01_08_423993	124	4	performed	perform	VBN
10_1101-2021_01_08_423993	124	5	without	without	IN
10_1101-2021_01_08_423993	124	6	the	the	DT
10_1101-2021_01_08_423993	124	7	use	use	NN
10_1101-2021_01_08_423993	124	8	of	of	IN
10_1101-2021_01_08_423993	124	9	IMAC	IMAC	NNP
10_1101-2021_01_08_423993	124	10	,	,	,
10_1101-2021_01_08_423993	124	11	to	to	TO
10_1101-2021_01_08_423993	124	12	avoid	avoid	VB
10_1101-2021_01_08_423993	124	13	the	the	DT
10_1101-2021_01_08_423993	124	14	introduction	introduction	NN
10_1101-2021_01_08_423993	124	15	of	of	IN
10_1101-2021_01_08_423993	124	16	Ni2	ni2	NN
10_1101-2021_01_08_423993	124	17	+	+	CC
10_1101-2021_01_08_423993	124	18	ions	ion	NNS
10_1101-2021_01_08_423993	124	19	during	during	IN
10_1101-2021_01_08_423993	124	20	purification	purification	NN
10_1101-2021_01_08_423993	124	21	.	.	.
10_1101-2021_01_08_423993	125	1	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	125	2	protein	protein	NN
10_1101-2021_01_08_423993	125	3	was	be	VBD
10_1101-2021_01_08_423993	125	4	purified	purify	VBN
10_1101-2021_01_08_423993	125	5	as	as	IN
10_1101-2021_01_08_423993	125	6	detailed	detail	VBN
10_1101-2021_01_08_423993	125	7	in	in	IN
10_1101-2021_01_08_423993	125	8	the	the	DT
10_1101-2021_01_08_423993	125	9	Methods	Methods	NNP
10_1101-2021_01_08_423993	125	10	&	&	CC
10_1101-2021_01_08_423993	125	11	Materials	Materials	NNPS
10_1101-2021_01_08_423993	125	12	,	,	,
10_1101-2021_01_08_423993	125	13	and	and	CC
10_1101-2021_01_08_423993	125	14	crystals	crystal	NNS
10_1101-2021_01_08_423993	125	15	were	be	VBD
10_1101-2021_01_08_423993	125	16	subsequently	subsequently	RB
10_1101-2021_01_08_423993	125	17	grown	grow	VBN
10_1101-2021_01_08_423993	125	18	and	and	CC
10_1101-2021_01_08_423993	125	19	diffracted	diffract	VBN
10_1101-2021_01_08_423993	125	20	to	to	IN
10_1101-2021_01_08_423993	125	21	1.6	1.6	CD
10_1101-2021_01_08_423993	125	22	Å	å	NN
10_1101-2021_01_08_423993	125	23	resolution	resolution	NN
10_1101-2021_01_08_423993	125	24	(	(	-LRB-
10_1101-2021_01_08_423993	125	25	Table	table	NN
10_1101-2021_01_08_423993	125	26	1	1	CD
10_1101-2021_01_08_423993	125	27	)	)	-RRB-
10_1101-2021_01_08_423993	125	28	;	;	:
10_1101-2021_01_08_423993	125	29	the	the	DT
10_1101-2021_01_08_423993	125	30	structure	structure	NN
10_1101-2021_01_08_423993	125	31	was	be	VBD
10_1101-2021_01_08_423993	125	32	solved	solve	VBN
10_1101-2021_01_08_423993	125	33	using	use	VBG
10_1101-2021_01_08_423993	125	34	a	a	DT
10_1101-2021_01_08_423993	125	35	structure	structure	NN
10_1101-2021_01_08_423993	125	36	of	of	IN
10_1101-2021_01_08_423993	125	37	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	125	38	(	(	-LRB-
10_1101-2021_01_08_423993	125	39	PDB	PDB	NNP
10_1101-2021_01_08_423993	125	40	coordinates	coordinate	VBZ
10_1101-2021_01_08_423993	125	41	5Q2A	5q2a	CD
10_1101-2021_01_08_423993	125	42	)	)	-RRB-
10_1101-2021_01_08_423993	125	43	as	as	IN
10_1101-2021_01_08_423993	125	44	the	the	DT
10_1101-2021_01_08_423993	125	45	molecular	molecular	JJ
10_1101-2021_01_08_423993	125	46	replacement	replacement	NN
10_1101-2021_01_08_423993	125	47	model	model	NN
10_1101-2021_01_08_423993	125	48	.	.	.
10_1101-2021_01_08_423993	126	1	The	the	DT
10_1101-2021_01_08_423993	126	2	resultant	resultant	JJ
10_1101-2021_01_08_423993	126	3	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	126	4	structure	structure	NN
10_1101-2021_01_08_423993	126	5	(	(	-LRB-
10_1101-2021_01_08_423993	126	6	PDB	PDB	NNP
10_1101-2021_01_08_423993	126	7	coordinates	coordinate	NNS
10_1101-2021_01_08_423993	126	8	7AF1	7af1	CD
10_1101-2021_01_08_423993	126	9	)	)	-RRB-
10_1101-2021_01_08_423993	126	10	contains	contain	VBZ
10_1101-2021_01_08_423993	126	11	a	a	DT
10_1101-2021_01_08_423993	126	12	single	single	JJ
10_1101-2021_01_08_423993	126	13	molecule	molecule	NN
10_1101-2021_01_08_423993	126	14	in	in	IN
10_1101-2021_01_08_423993	126	15	the	the	DT
10_1101-2021_01_08_423993	126	16	.CC	.CC	NFP
10_1101-2021_01_08_423993	126	17	-	-	:
10_1101-2021_01_08_423993	126	18	BY	by	IN
10_1101-2021_01_08_423993	126	19	4.0	4.0	CD
10_1101-2021_01_08_423993	126	20	International	international	JJ
10_1101-2021_01_08_423993	126	21	licensemade	licensemade	NN
10_1101-2021_01_08_423993	126	22	available	available	JJ
10_1101-2021_01_08_423993	126	23	under	under	IN
10_1101-2021_01_08_423993	126	24	a	a	DT
10_1101-2021_01_08_423993	126	25	(	(	-LRB-
10_1101-2021_01_08_423993	126	26	which	which	WDT
10_1101-2021_01_08_423993	126	27	was	be	VBD
10_1101-2021_01_08_423993	126	28	not	not	RB
10_1101-2021_01_08_423993	126	29	certified	certify	VBN
10_1101-2021_01_08_423993	126	30	by	by	IN
10_1101-2021_01_08_423993	126	31	peer	peer	NN
10_1101-2021_01_08_423993	126	32	review	review	NN
10_1101-2021_01_08_423993	126	33	)	)	-RRB-
10_1101-2021_01_08_423993	126	34	is	be	VBZ
10_1101-2021_01_08_423993	126	35	the	the	DT
10_1101-2021_01_08_423993	126	36	author	author	NN
10_1101-2021_01_08_423993	126	37	/	/	SYM
10_1101-2021_01_08_423993	126	38	funder	funder	NN
10_1101-2021_01_08_423993	126	39	,	,	,
10_1101-2021_01_08_423993	126	40	who	who	WP
10_1101-2021_01_08_423993	126	41	has	have	VBZ
10_1101-2021_01_08_423993	126	42	granted	grant	VBN
10_1101-2021_01_08_423993	126	43	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	126	44	a	a	DT
10_1101-2021_01_08_423993	126	45	license	license	NN
10_1101-2021_01_08_423993	126	46	to	to	TO
10_1101-2021_01_08_423993	126	47	display	display	VB
10_1101-2021_01_08_423993	126	48	the	the	DT
10_1101-2021_01_08_423993	126	49	preprint	preprint	NN
10_1101-2021_01_08_423993	126	50	in	in	IN
10_1101-2021_01_08_423993	126	51	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	126	52	.	.	.
10_1101-2021_01_08_423993	127	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	127	2	is	be	VBZ
10_1101-2021_01_08_423993	127	3	The	the	DT
10_1101-2021_01_08_423993	127	4	copyright	copyright	NN
10_1101-2021_01_08_423993	127	5	holder	holder	NN
10_1101-2021_01_08_423993	127	6	for	for	IN
10_1101-2021_01_08_423993	127	7	this	this	DT
10_1101-2021_01_08_423993	127	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	127	9	version	version	NN
10_1101-2021_01_08_423993	127	10	posted	post	VBD
10_1101-2021_01_08_423993	127	11	January	January	NNP
10_1101-2021_01_08_423993	127	12	8	8	CD
10_1101-2021_01_08_423993	127	13	,	,	,
10_1101-2021_01_08_423993	127	14	2021	2021	CD
10_1101-2021_01_08_423993	127	15	.	.	.
10_1101-2021_01_08_423993	127	16	;	;	:
10_1101-2021_01_08_423993	127	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	127	18	:	:	:
10_1101-2021_01_08_423993	127	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	127	20	preprint	preprint	NN
10_1101-2021_01_08_423993	127	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	NN
10_1101-2021_01_08_423993	127	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	NNP
10_1101-2021_01_08_423993	127	23	asymmetric	asymmetric	JJ
10_1101-2021_01_08_423993	127	24	unit	unit	NN
10_1101-2021_01_08_423993	127	25	,	,	,
10_1101-2021_01_08_423993	127	26	with	with	IN
10_1101-2021_01_08_423993	127	27	two	two	CD
10_1101-2021_01_08_423993	127	28	zinc	zinc	NN
10_1101-2021_01_08_423993	127	29	ions	ion	NNS
10_1101-2021_01_08_423993	127	30	coordinated	coordinate	VBN
10_1101-2021_01_08_423993	127	31	at	at	IN
10_1101-2021_01_08_423993	127	32	the	the	DT
10_1101-2021_01_08_423993	127	33	active	active	JJ
10_1101-2021_01_08_423993	127	34	site	site	NN
10_1101-2021_01_08_423993	127	35	.	.	.
10_1101-2021_01_08_423993	128	1	The	the	DT
10_1101-2021_01_08_423993	128	2	metal	metal	NN
10_1101-2021_01_08_423993	128	3	ions	ion	NNS
10_1101-2021_01_08_423993	128	4	were	be	VBD
10_1101-2021_01_08_423993	128	5	identified	identify	VBN
10_1101-2021_01_08_423993	128	6	using	use	VBG
10_1101-2021_01_08_423993	128	7	X	x	NN
10_1101-2021_01_08_423993	128	8	-	-	NN
10_1101-2021_01_08_423993	128	9	ray	ray	NN
10_1101-2021_01_08_423993	128	10	fluorescence	fluorescence	NN
10_1101-2021_01_08_423993	128	11	(	(	-LRB-
10_1101-2021_01_08_423993	128	12	XRF	XRF	NNP
10_1101-2021_01_08_423993	128	13	)	)	-RRB-
10_1101-2021_01_08_423993	128	14	analysis	analysis	NN
10_1101-2021_01_08_423993	128	15	during	during	IN
10_1101-2021_01_08_423993	128	16	data	datum	NNS
10_1101-2021_01_08_423993	128	17	collection	collection	NN
10_1101-2021_01_08_423993	128	18	at	at	IN
10_1101-2021_01_08_423993	128	19	the	the	DT
10_1101-2021_01_08_423993	128	20	Diamond	Diamond	NNP
10_1101-2021_01_08_423993	128	21	Light	Light	NNP
10_1101-2021_01_08_423993	128	22	source	source	NN
10_1101-2021_01_08_423993	128	23	.	.	.
10_1101-2021_01_08_423993	129	1	When	when	WRB
10_1101-2021_01_08_423993	129	2	using	use	VBG
10_1101-2021_01_08_423993	129	3	the	the	DT
10_1101-2021_01_08_423993	129	4	protein	protein	NN
10_1101-2021_01_08_423993	129	5	purified	purify	VBD
10_1101-2021_01_08_423993	129	6	using	use	VBG
10_1101-2021_01_08_423993	129	7	IMAC	IMAC	NNP
10_1101-2021_01_08_423993	129	8	,	,	,
10_1101-2021_01_08_423993	129	9	the	the	DT
10_1101-2021_01_08_423993	129	10	first	first	JJ
10_1101-2021_01_08_423993	129	11	zinc	zinc	NN
10_1101-2021_01_08_423993	129	12	ion	ion	NN
10_1101-2021_01_08_423993	129	13	in	in	IN
10_1101-2021_01_08_423993	129	14	the	the	DT
10_1101-2021_01_08_423993	129	15	active	active	JJ
10_1101-2021_01_08_423993	129	16	site	site	NN
10_1101-2021_01_08_423993	129	17	can	can	MD
10_1101-2021_01_08_423993	129	18	be	be	VB
10_1101-2021_01_08_423993	129	19	replaced	replace	VBN
10_1101-2021_01_08_423993	129	20	by	by	IN
10_1101-2021_01_08_423993	129	21	a	a	DT
10_1101-2021_01_08_423993	129	22	nickel	nickel	NN
10_1101-2021_01_08_423993	129	23	ion	ion	NN
10_1101-2021_01_08_423993	129	24	(	(	-LRB-
10_1101-2021_01_08_423993	129	25	PDB	pdb	NN
10_1101-2021_01_08_423993	129	26	:	:	:
10_1101-2021_01_08_423993	129	27	6TT5	6tt5	LS
10_1101-2021_01_08_423993	129	28	)	)	-RRB-
10_1101-2021_01_08_423993	129	29	(	(	-LRB-
10_1101-2021_01_08_423993	129	30	Figure	figure	NN
10_1101-2021_01_08_423993	129	31	2E	2e	NN
10_1101-2021_01_08_423993	129	32	)	)	-RRB-
10_1101-2021_01_08_423993	129	33	.	.	.
10_1101-2021_01_08_423993	130	1	The	the	DT
10_1101-2021_01_08_423993	130	2	presence	presence	NN
10_1101-2021_01_08_423993	130	3	of	of	IN
10_1101-2021_01_08_423993	130	4	the	the	DT
10_1101-2021_01_08_423993	130	5	nickel	nickel	NN
10_1101-2021_01_08_423993	130	6	ion	ion	NN
10_1101-2021_01_08_423993	130	7	was	be	VBD
10_1101-2021_01_08_423993	130	8	also	also	RB
10_1101-2021_01_08_423993	130	9	confirmed	confirm	VBN
10_1101-2021_01_08_423993	130	10	in	in	IN
10_1101-2021_01_08_423993	130	11	the	the	DT
10_1101-2021_01_08_423993	130	12	crystal	crystal	NN
10_1101-2021_01_08_423993	130	13	by	by	IN
10_1101-2021_01_08_423993	130	14	XRF	XRF	NNP
10_1101-2021_01_08_423993	130	15	.	.	.
10_1101-2021_01_08_423993	131	1	The	the	DT
10_1101-2021_01_08_423993	131	2	X	X	NNP
10_1101-2021_01_08_423993	131	3	-	-	NN
10_1101-2021_01_08_423993	131	4	ray	ray	NN
10_1101-2021_01_08_423993	131	5	fluorescence	fluorescence	NN
10_1101-2021_01_08_423993	131	6	analysis	analysis	NN
10_1101-2021_01_08_423993	131	7	of	of	IN
10_1101-2021_01_08_423993	131	8	the	the	DT
10_1101-2021_01_08_423993	131	9	metal	metal	NN
10_1101-2021_01_08_423993	131	10	ions	ion	NNS
10_1101-2021_01_08_423993	131	11	present	present	JJ
10_1101-2021_01_08_423993	131	12	in	in	IN
10_1101-2021_01_08_423993	131	13	the	the	DT
10_1101-2021_01_08_423993	131	14	structures	structure	NNS
10_1101-2021_01_08_423993	131	15	are	be	VBP
10_1101-2021_01_08_423993	131	16	shown	show	VBN
10_1101-2021_01_08_423993	131	17	in	in	IN
10_1101-2021_01_08_423993	131	18	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	131	19	.	.	.
10_1101-2021_01_08_423993	132	1	Figure	figure	NN
10_1101-2021_01_08_423993	132	2	1	1	CD
10_1101-2021_01_08_423993	132	3	.	.	.
10_1101-2021_01_08_423993	133	1	This	this	DT
10_1101-2021_01_08_423993	133	2	metal	metal	NN
10_1101-2021_01_08_423993	133	3	ion	ion	NN
10_1101-2021_01_08_423993	133	4	coordination	coordination	NN
10_1101-2021_01_08_423993	133	5	pattern	pattern	NN
10_1101-2021_01_08_423993	133	6	has	have	VBZ
10_1101-2021_01_08_423993	133	7	been	be	VBN
10_1101-2021_01_08_423993	133	8	observed	observe	VBN
10_1101-2021_01_08_423993	133	9	with	with	IN
10_1101-2021_01_08_423993	133	10	other	other	JJ
10_1101-2021_01_08_423993	133	11	member	member	NN
10_1101-2021_01_08_423993	133	12	of	of	IN
10_1101-2021_01_08_423993	133	13	the	the	DT
10_1101-2021_01_08_423993	133	14	family	family	NN
10_1101-2021_01_08_423993	133	15	,	,	,
10_1101-2021_01_08_423993	133	16	such	such	JJ
10_1101-2021_01_08_423993	133	17	as	as	IN
10_1101-2021_01_08_423993	133	18	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	133	19	and	and	CC
10_1101-2021_01_08_423993	133	20	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	133	21	/	/	SYM
10_1101-2021_01_08_423993	133	22	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	133	23	[	[	-LRB-
10_1101-2021_01_08_423993	133	24	3,9	3,9	CD
10_1101-2021_01_08_423993	133	25	]	]	-RRB-
10_1101-2021_01_08_423993	133	26	.	.	.
10_1101-2021_01_08_423993	134	1	The	the	DT
10_1101-2021_01_08_423993	134	2	overall	overall	JJ
10_1101-2021_01_08_423993	134	3	fold	fold	NN
10_1101-2021_01_08_423993	134	4	of	of	IN
10_1101-2021_01_08_423993	134	5	human	human	JJ
10_1101-2021_01_08_423993	134	6	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	134	7	protein	protein	NN
10_1101-2021_01_08_423993	134	8	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	134	9	core	core	NN
10_1101-2021_01_08_423993	134	10	is	be	VBZ
10_1101-2021_01_08_423993	134	11	very	very	RB
10_1101-2021_01_08_423993	134	12	similar	similar	JJ
10_1101-2021_01_08_423993	134	13	to	to	IN
10_1101-2021_01_08_423993	134	14	that	that	DT
10_1101-2021_01_08_423993	134	15	of	of	IN
10_1101-2021_01_08_423993	134	16	human	human	JJ
10_1101-2021_01_08_423993	134	17	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	134	18	and	and	CC
10_1101-2021_01_08_423993	134	19	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	134	20	/	/	SYM
10_1101-2021_01_08_423993	134	21	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	134	22	(	(	-LRB-
10_1101-2021_01_08_423993	134	23	2	2	CD
10_1101-2021_01_08_423993	134	24	Å	Å	NNP
10_1101-2021_01_08_423993	134	25	RMSD	RMSD	NNP
10_1101-2021_01_08_423993	134	26	)	)	-RRB-
10_1101-2021_01_08_423993	134	27	.	.	.
10_1101-2021_01_08_423993	135	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	135	2	has	have	VBZ
10_1101-2021_01_08_423993	135	3	the	the	DT
10_1101-2021_01_08_423993	135	4	key	key	JJ
10_1101-2021_01_08_423993	135	5	structural	structural	JJ
10_1101-2021_01_08_423993	135	6	characteristics	characteristic	NNS
10_1101-2021_01_08_423993	135	7	of	of	IN
10_1101-2021_01_08_423993	135	8	human	human	JJ
10_1101-2021_01_08_423993	135	9	MBL	MBL	NNP
10_1101-2021_01_08_423993	135	10	fold	fold	VBP
10_1101-2021_01_08_423993	135	11	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	135	12	,	,	,
10_1101-2021_01_08_423993	135	13	with	with	IN
10_1101-2021_01_08_423993	135	14	the	the	DT
10_1101-2021_01_08_423993	135	15	di	di	JJ
10_1101-2021_01_08_423993	135	16	-	-	HYPH
10_1101-2021_01_08_423993	135	17	metal	metal	NN
10_1101-2021_01_08_423993	135	18	containing	contain	VBG
10_1101-2021_01_08_423993	135	19	active	active	JJ
10_1101-2021_01_08_423993	135	20	site	site	NN
10_1101-2021_01_08_423993	135	21	interfaced	interface	VBN
10_1101-2021_01_08_423993	135	22	between	between	IN
10_1101-2021_01_08_423993	135	23	the	the	DT
10_1101-2021_01_08_423993	135	24	MBL	MBL	NNP
10_1101-2021_01_08_423993	135	25	and	and	CC
10_1101-2021_01_08_423993	135	26	β	β	NNP
10_1101-2021_01_08_423993	135	27	-	-	HYPH
10_1101-2021_01_08_423993	135	28	CASP	CASP	NNP
10_1101-2021_01_08_423993	135	29	domains	domain	NNS
10_1101-2021_01_08_423993	135	30	(	(	-LRB-
10_1101-2021_01_08_423993	135	31	Figure	figure	NN
10_1101-2021_01_08_423993	135	32	1A	1a	NN
10_1101-2021_01_08_423993	135	33	)	)	-RRB-
10_1101-2021_01_08_423993	135	34	.	.	.
10_1101-2021_01_08_423993	136	1	As	as	IN
10_1101-2021_01_08_423993	136	2	anticipated	anticipate	VBN
10_1101-2021_01_08_423993	136	3	,	,	,
10_1101-2021_01_08_423993	136	4	the	the	DT
10_1101-2021_01_08_423993	136	5	MBL	MBL	NNP
10_1101-2021_01_08_423993	136	6	domain	domain	NN
10_1101-2021_01_08_423993	136	7	(	(	-LRB-
10_1101-2021_01_08_423993	136	8	Figure	figure	NN
10_1101-2021_01_08_423993	136	9	1A	1a	NN
10_1101-2021_01_08_423993	136	10	and	and	CC
10_1101-2021_01_08_423993	136	11	1B	1b	NN
10_1101-2021_01_08_423993	136	12	,	,	,
10_1101-2021_01_08_423993	136	13	in	in	IN
10_1101-2021_01_08_423993	136	14	pink	pink	NN
10_1101-2021_01_08_423993	136	15	)	)	-RRB-
10_1101-2021_01_08_423993	136	16	of	of	IN
10_1101-2021_01_08_423993	136	17	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	136	18	has	have	VBZ
10_1101-2021_01_08_423993	136	19	the	the	DT
10_1101-2021_01_08_423993	136	20	typical	typical	JJ
10_1101-2021_01_08_423993	136	21	α	α	NNP
10_1101-2021_01_08_423993	136	22	/	/	SYM
10_1101-2021_01_08_423993	136	23	β	β	NNP
10_1101-2021_01_08_423993	136	24	-	-	HYPH
10_1101-2021_01_08_423993	136	25	β	β	NNP
10_1101-2021_01_08_423993	136	26	/	/	SYM
10_1101-2021_01_08_423993	136	27	α	α	NNP
10_1101-2021_01_08_423993	136	28	sandwich	sandwich	NN
10_1101-2021_01_08_423993	136	29	MBL	MBL	NNP
10_1101-2021_01_08_423993	136	30	fold	fold	VB
10_1101-2021_01_08_423993	136	31	[	[	-LRB-
10_1101-2021_01_08_423993	136	32	42	42	CD
10_1101-2021_01_08_423993	136	33	]	]	-RRB-
10_1101-2021_01_08_423993	136	34	and	and	CC
10_1101-2021_01_08_423993	136	35	contains	contain	VBZ
10_1101-2021_01_08_423993	136	36	all	all	DT
10_1101-2021_01_08_423993	136	37	of	of	IN
10_1101-2021_01_08_423993	136	38	the	the	DT
10_1101-2021_01_08_423993	136	39	highly	highly	RB
10_1101-2021_01_08_423993	136	40	conserved	conserve	VBN
10_1101-2021_01_08_423993	136	41	motifs	motif	NNS
10_1101-2021_01_08_423993	136	42	1–4	1–4	CD
10_1101-2021_01_08_423993	136	43	(	(	-LRB-
10_1101-2021_01_08_423993	136	44	Figure	figure	NN
10_1101-2021_01_08_423993	136	45	1C	1c	NN
10_1101-2021_01_08_423993	136	46	and	and	CC
10_1101-2021_01_08_423993	136	47	D	d	NN
10_1101-2021_01_08_423993	136	48	;	;	:
10_1101-2021_01_08_423993	136	49	and	and	CC
10_1101-2021_01_08_423993	136	50	sequence	sequence	NN
10_1101-2021_01_08_423993	136	51	alignment	alignment	NN
10_1101-2021_01_08_423993	136	52	,	,	,
10_1101-2021_01_08_423993	136	53	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	136	54	.	.	.
10_1101-2021_01_08_423993	137	1	Figure	figure	NN
10_1101-2021_01_08_423993	137	2	2	2	CD
10_1101-2021_01_08_423993	137	3	)	)	-RRB-
10_1101-2021_01_08_423993	137	4	which	which	WDT
10_1101-2021_01_08_423993	137	5	are	be	VBP
10_1101-2021_01_08_423993	137	6	typical	typical	JJ
10_1101-2021_01_08_423993	137	7	for	for	IN
10_1101-2021_01_08_423993	137	8	the	the	DT
10_1101-2021_01_08_423993	137	9	whole	whole	JJ
10_1101-2021_01_08_423993	137	10	MBL	MBL	NNP
10_1101-2021_01_08_423993	137	11	superfamily	superfamily	RB
10_1101-2021_01_08_423993	137	12	,	,	,
10_1101-2021_01_08_423993	137	13	and	and	CC
10_1101-2021_01_08_423993	137	14	motif	motif	NN
10_1101-2021_01_08_423993	137	15	A	a	DT
10_1101-2021_01_08_423993	137	16	–	–	:
10_1101-2021_01_08_423993	137	17	C	c	NN
10_1101-2021_01_08_423993	137	18	which	which	WDT
10_1101-2021_01_08_423993	137	19	are	be	VBP
10_1101-2021_01_08_423993	137	20	typical	typical	JJ
10_1101-2021_01_08_423993	137	21	of	of	IN
10_1101-2021_01_08_423993	137	22	the	the	DT
10_1101-2021_01_08_423993	137	23	β	β	NNP
10_1101-2021_01_08_423993	137	24	-	-	HYPH
10_1101-2021_01_08_423993	137	25	CASP	CASP	NNP
10_1101-2021_01_08_423993	137	26	fold	fold	VBP
10_1101-2021_01_08_423993	137	27	containing	contain	VBG
10_1101-2021_01_08_423993	137	28	family	family	NN
10_1101-2021_01_08_423993	137	29	[	[	-LRB-
10_1101-2021_01_08_423993	137	30	2,27,43,44	2,27,43,44	CD
10_1101-2021_01_08_423993	137	31	]	]	-RRB-
10_1101-2021_01_08_423993	137	32	.	.	.
10_1101-2021_01_08_423993	138	1	Motifs	Motifs	NNP
10_1101-2021_01_08_423993	138	2	1–4	1–4	CD
10_1101-2021_01_08_423993	138	3	(	(	-LRB-
10_1101-2021_01_08_423993	138	4	Figures	figure	NNS
10_1101-2021_01_08_423993	138	5	1D	1d	CD
10_1101-2021_01_08_423993	138	6	and	and	CC
10_1101-2021_01_08_423993	138	7	2C	2c	NN
10_1101-2021_01_08_423993	138	8	)	)	-RRB-
10_1101-2021_01_08_423993	138	9	are	be	VBP
10_1101-2021_01_08_423993	138	10	responsible	responsible	JJ
10_1101-2021_01_08_423993	138	11	for	for	IN
10_1101-2021_01_08_423993	138	12	metal	metal	NN
10_1101-2021_01_08_423993	138	13	ion	ion	NN
10_1101-2021_01_08_423993	138	14	coordination	coordination	NN
10_1101-2021_01_08_423993	138	15	in	in	IN
10_1101-2021_01_08_423993	138	16	both	both	CC
10_1101-2021_01_08_423993	138	17	DNA	DNA	NNP
10_1101-2021_01_08_423993	138	18	and	and	CC
10_1101-2021_01_08_423993	138	19	RNA	RNA	NNP
10_1101-2021_01_08_423993	138	20	processing	processing	NN
10_1101-2021_01_08_423993	138	21	MBL	MBL	NNP
10_1101-2021_01_08_423993	138	22	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	138	23	[	[	-LRB-
10_1101-2021_01_08_423993	138	24	44	44	CD
10_1101-2021_01_08_423993	138	25	]	]	-RRB-
10_1101-2021_01_08_423993	138	26	.	.	.
10_1101-2021_01_08_423993	139	1	As	as	IN
10_1101-2021_01_08_423993	139	2	previously	previously	RB
10_1101-2021_01_08_423993	139	3	observed	observe	VBN
10_1101-2021_01_08_423993	139	4	in	in	IN
10_1101-2021_01_08_423993	139	5	crystal	crystal	JJ
10_1101-2021_01_08_423993	139	6	structures	structure	NNS
10_1101-2021_01_08_423993	139	7	of	of	IN
10_1101-2021_01_08_423993	139	8	human	human	NN
10_1101-2021_01_08_423993	139	9	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	139	10	and	and	CC
10_1101-2021_01_08_423993	139	11	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	139	12	/	/	SYM
10_1101-2021_01_08_423993	139	13	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	139	14	,	,	,
10_1101-2021_01_08_423993	139	15	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	139	16	can	can	MD
10_1101-2021_01_08_423993	139	17	coordinate	coordinate	VB
10_1101-2021_01_08_423993	139	18	one	one	CD
10_1101-2021_01_08_423993	139	19	or	or	CC
10_1101-2021_01_08_423993	139	20	two	two	CD
10_1101-2021_01_08_423993	139	21	metal	metal	NN
10_1101-2021_01_08_423993	139	22	ions	ion	NNS
10_1101-2021_01_08_423993	139	23	in	in	IN
10_1101-2021_01_08_423993	139	24	its	-PRON-	PRP$
10_1101-2021_01_08_423993	139	25	active	active	JJ
10_1101-2021_01_08_423993	139	26	site	site	NN
10_1101-2021_01_08_423993	139	27	.	.	.
10_1101-2021_01_08_423993	140	1	One	one	CD
10_1101-2021_01_08_423993	140	2	zinc	zinc	NN
10_1101-2021_01_08_423993	140	3	ion	ion	NN
10_1101-2021_01_08_423993	140	4	(	(	-LRB-
10_1101-2021_01_08_423993	140	5	Zn1	zn1	NN
10_1101-2021_01_08_423993	140	6	)	)	-RRB-
10_1101-2021_01_08_423993	140	7	in	in	IN
10_1101-2021_01_08_423993	140	8	the	the	DT
10_1101-2021_01_08_423993	140	9	active	active	JJ
10_1101-2021_01_08_423993	140	10	site	site	NN
10_1101-2021_01_08_423993	140	11	is	be	VBZ
10_1101-2021_01_08_423993	140	12	coordinated	coordinate	VBN
10_1101-2021_01_08_423993	140	13	by	by	IN
10_1101-2021_01_08_423993	140	14	four	four	CD
10_1101-2021_01_08_423993	140	15	residues	residue	NNS
10_1101-2021_01_08_423993	140	16	(	(	-LRB-
10_1101-2021_01_08_423993	140	17	His33	His33	NNP
10_1101-2021_01_08_423993	140	18	,	,	,
10_1101-2021_01_08_423993	140	19	His35	His35	NNP
10_1101-2021_01_08_423993	140	20	,	,	,
10_1101-2021_01_08_423993	140	21	His115	his115	CD
10_1101-2021_01_08_423993	140	22	,	,	,
10_1101-2021_01_08_423993	140	23	and	and	CC
10_1101-2021_01_08_423993	140	24	Asp116	Asp116	NNS
10_1101-2021_01_08_423993	140	25	)	)	-RRB-
10_1101-2021_01_08_423993	140	26	and	and	CC
10_1101-2021_01_08_423993	140	27	two	two	CD
10_1101-2021_01_08_423993	140	28	water	water	NN
10_1101-2021_01_08_423993	140	29	molecules	molecule	NNS
10_1101-2021_01_08_423993	140	30	(	(	-LRB-
10_1101-2021_01_08_423993	140	31	H2O	h2o	NN
10_1101-2021_01_08_423993	140	32	506	506	CD
10_1101-2021_01_08_423993	140	33	and	and	CC
10_1101-2021_01_08_423993	140	34	611	611	CD
10_1101-2021_01_08_423993	140	35	)	)	-RRB-
10_1101-2021_01_08_423993	140	36	in	in	IN
10_1101-2021_01_08_423993	140	37	an	an	DT
10_1101-2021_01_08_423993	140	38	octahedral	octahedral	JJ
10_1101-2021_01_08_423993	140	39	manner	manner	NN
10_1101-2021_01_08_423993	140	40	(	(	-LRB-
10_1101-2021_01_08_423993	140	41	Figure	figure	NN
10_1101-2021_01_08_423993	140	42	2C	2c	NN
10_1101-2021_01_08_423993	140	43	)	)	-RRB-
10_1101-2021_01_08_423993	140	44	.	.	.
10_1101-2021_01_08_423993	141	1	The	the	DT
10_1101-2021_01_08_423993	141	2	second	second	JJ
10_1101-2021_01_08_423993	141	3	zinc	zinc	NN
10_1101-2021_01_08_423993	141	4	ion	ion	NN
10_1101-2021_01_08_423993	141	5	(	(	-LRB-
10_1101-2021_01_08_423993	141	6	Zn2	Zn2	NNP
10_1101-2021_01_08_423993	141	7	)	)	-RRB-
10_1101-2021_01_08_423993	141	8	was	be	VBD
10_1101-2021_01_08_423993	141	9	refined	refine	VBN
10_1101-2021_01_08_423993	141	10	with	with	IN
10_1101-2021_01_08_423993	141	11	30	30	CD
10_1101-2021_01_08_423993	141	12	%	%	NN
10_1101-2021_01_08_423993	141	13	occupancy	occupancy	NN
10_1101-2021_01_08_423993	141	14	and	and	CC
10_1101-2021_01_08_423993	141	15	is	be	VBZ
10_1101-2021_01_08_423993	141	16	coordinated	coordinate	VBN
10_1101-2021_01_08_423993	141	17	by	by	IN
10_1101-2021_01_08_423993	141	18	three	three	CD
10_1101-2021_01_08_423993	141	19	residues	residue	NNS
10_1101-2021_01_08_423993	141	20	(	(	-LRB-
10_1101-2021_01_08_423993	141	21	Asp37	Asp37	NNP
10_1101-2021_01_08_423993	141	22	,	,	,
10_1101-2021_01_08_423993	141	23	His38	His38	NNP
10_1101-2021_01_08_423993	141	24	,	,	,
10_1101-2021_01_08_423993	141	25	and	and	CC
10_1101-2021_01_08_423993	141	26	Asp136	asp136	CD
10_1101-2021_01_08_423993	141	27	)	)	-RRB-
10_1101-2021_01_08_423993	141	28	and	and	CC
10_1101-2021_01_08_423993	141	29	two	two	CD
10_1101-2021_01_08_423993	141	30	water	water	NN
10_1101-2021_01_08_423993	141	31	molecules	molecule	NNS
10_1101-2021_01_08_423993	141	32	(	(	-LRB-
10_1101-2021_01_08_423993	141	33	H2O	h2o	NN
10_1101-2021_01_08_423993	141	34	506	506	CD
10_1101-2021_01_08_423993	141	35	and	and	CC
10_1101-2021_01_08_423993	141	36	529	529	CD
10_1101-2021_01_08_423993	141	37	)	)	-RRB-
10_1101-2021_01_08_423993	141	38	.	.	.
10_1101-2021_01_08_423993	142	1	The	the	DT
10_1101-2021_01_08_423993	142	2	low	low	JJ
10_1101-2021_01_08_423993	142	3	occupancy	occupancy	NN
10_1101-2021_01_08_423993	142	4	of	of	IN
10_1101-2021_01_08_423993	142	5	the	the	DT
10_1101-2021_01_08_423993	142	6	second	second	JJ
10_1101-2021_01_08_423993	142	7	zinc	zinc	NN
10_1101-2021_01_08_423993	142	8	ion	ion	NN
10_1101-2021_01_08_423993	142	9	,	,	,
10_1101-2021_01_08_423993	142	10	together	together	RB
10_1101-2021_01_08_423993	142	11	with	with	IN
10_1101-2021_01_08_423993	142	12	the	the	DT
10_1101-2021_01_08_423993	142	13	two	two	CD
10_1101-2021_01_08_423993	142	14	conformations	conformation	NNS
10_1101-2021_01_08_423993	142	15	(	(	-LRB-
10_1101-2021_01_08_423993	142	16	0.5	0.5	CD
10_1101-2021_01_08_423993	142	17	occupancy	occupancy	NN
10_1101-2021_01_08_423993	142	18	for	for	IN
10_1101-2021_01_08_423993	142	19	each	each	DT
10_1101-2021_01_08_423993	142	20	conformation	conformation	NN
10_1101-2021_01_08_423993	142	21	)	)	-RRB-
10_1101-2021_01_08_423993	142	22	observed	observe	VBN
10_1101-2021_01_08_423993	142	23	for	for	IN
10_1101-2021_01_08_423993	142	24	Asp37	Asp37	NNP
10_1101-2021_01_08_423993	142	25	(	(	-LRB-
10_1101-2021_01_08_423993	142	26	Figure	Figure	NNP
10_1101-2021_01_08_423993	142	27	2E	2e	LS
10_1101-2021_01_08_423993	142	28	)	)	-RRB-
10_1101-2021_01_08_423993	142	29	suggest	suggest	VB
10_1101-2021_01_08_423993	142	30	that	that	IN
10_1101-2021_01_08_423993	142	31	this	this	DT
10_1101-2021_01_08_423993	142	32	site	site	NN
10_1101-2021_01_08_423993	142	33	binds	bind	VBZ
10_1101-2021_01_08_423993	142	34	a	a	DT
10_1101-2021_01_08_423993	142	35	metal	metal	NN
10_1101-2021_01_08_423993	142	36	ion	ion	NN
10_1101-2021_01_08_423993	142	37	less	less	RBR
10_1101-2021_01_08_423993	142	38	tightly	tightly	RB
10_1101-2021_01_08_423993	142	39	than	than	IN
10_1101-2021_01_08_423993	142	40	the	the	DT
10_1101-2021_01_08_423993	142	41	Zn1	zn1	NN
10_1101-2021_01_08_423993	142	42	site	site	NN
10_1101-2021_01_08_423993	142	43	,	,	,
10_1101-2021_01_08_423993	142	44	consistent	consistent	JJ
10_1101-2021_01_08_423993	142	45	with	with	IN
10_1101-2021_01_08_423993	142	46	studies	study	NNS
10_1101-2021_01_08_423993	142	47	on	on	IN
10_1101-2021_01_08_423993	142	48	other	other	JJ
10_1101-2021_01_08_423993	142	49	human	human	JJ
10_1101-2021_01_08_423993	142	50	MBL	mbl	NN
10_1101-2021_01_08_423993	142	51	fold	fold	VB
10_1101-2021_01_08_423993	142	52	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	142	53	[	[	-LRB-
10_1101-2021_01_08_423993	142	54	3	3	CD
10_1101-2021_01_08_423993	142	55	,	,	,
10_1101-2021_01_08_423993	142	56	Baddock	Baddock	NNP
10_1101-2021_01_08_423993	142	57	et	et	NNP
10_1101-2021_01_08_423993	142	58	.	.	.
10_1101-2021_01_08_423993	143	1	al	al	NNP
10_1101-2021_01_08_423993	143	2	.	.	NNP
10_1101-2021_01_08_423993	143	3	,2020	,2020	,
10_1101-2021_01_08_423993	143	4	]	]	-RRB-
10_1101-2021_01_08_423993	143	5	The	the	DT
10_1101-2021_01_08_423993	143	6	structure	structure	NN
10_1101-2021_01_08_423993	143	7	of	of	IN
10_1101-2021_01_08_423993	143	8	human	human	JJ
10_1101-2021_01_08_423993	143	9	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	143	10	(	(	-LRB-
10_1101-2021_01_08_423993	143	11	PDB	PDB	NNP
10_1101-2021_01_08_423993	143	12	:	:	:
10_1101-2021_01_08_423993	143	13	5AHR	5AHR	NNP
10_1101-2021_01_08_423993	143	14	)	)	-RRB-
10_1101-2021_01_08_423993	143	15	[	[	-LRB-
10_1101-2021_01_08_423993	143	16	3	3	CD
10_1101-2021_01_08_423993	143	17	]	]	-RRB-
10_1101-2021_01_08_423993	143	18	was	be	VBD
10_1101-2021_01_08_423993	143	19	solved	solve	VBN
10_1101-2021_01_08_423993	143	20	with	with	IN
10_1101-2021_01_08_423993	143	21	a	a	DT
10_1101-2021_01_08_423993	143	22	single	single	JJ
10_1101-2021_01_08_423993	143	23	zinc	zinc	NN
10_1101-2021_01_08_423993	143	24	ion	ion	NN
10_1101-2021_01_08_423993	143	25	coordinated	coordinate	VBN
10_1101-2021_01_08_423993	143	26	in	in	IN
10_1101-2021_01_08_423993	143	27	the	the	DT
10_1101-2021_01_08_423993	143	28	active	active	JJ
10_1101-2021_01_08_423993	143	29	site	site	NN
10_1101-2021_01_08_423993	143	30	(	(	-LRB-
10_1101-2021_01_08_423993	143	31	Figure	Figure	NNP
10_1101-2021_01_08_423993	143	32	2A	2a	NN
10_1101-2021_01_08_423993	143	33	)	)	-RRB-
10_1101-2021_01_08_423993	143	34	.	.	.
10_1101-2021_01_08_423993	144	1	By	by	IN
10_1101-2021_01_08_423993	144	2	contrast	contrast	NN
10_1101-2021_01_08_423993	144	3	,	,	,
10_1101-2021_01_08_423993	144	4	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	144	5	structures	structure	NNS
10_1101-2021_01_08_423993	144	6	solved	solve	VBD
10_1101-2021_01_08_423993	144	7	with	with	IN
10_1101-2021_01_08_423993	144	8	a	a	DT
10_1101-2021_01_08_423993	144	9	bound	bind	VBN
10_1101-2021_01_08_423993	144	10	AMP	AMP	NNP
10_1101-2021_01_08_423993	144	11	(	(	-LRB-
10_1101-2021_01_08_423993	144	12	Baddock	Baddock	NNP
10_1101-2021_01_08_423993	144	13	et	et	NNP
10_1101-2021_01_08_423993	144	14	.	.	.
10_1101-2021_01_08_423993	145	1	al	al	NNP
10_1101-2021_01_08_423993	145	2	.	.	NNP
10_1101-2021_01_08_423993	145	3	,	,	,
10_1101-2021_01_08_423993	145	4	accompanying	accompany	VBG
10_1101-2021_01_08_423993	145	5	paper	paper	NN
10_1101-2021_01_08_423993	145	6	)	)	-RRB-
10_1101-2021_01_08_423993	145	7	showed	show	VBD
10_1101-2021_01_08_423993	145	8	that	that	IN
10_1101-2021_01_08_423993	145	9	both	both	DT
10_1101-2021_01_08_423993	145	10	metal	metal	NN
10_1101-2021_01_08_423993	145	11	ions	ion	NNS
10_1101-2021_01_08_423993	145	12	are	be	VBP
10_1101-2021_01_08_423993	145	13	positioned	position	VBN
10_1101-2021_01_08_423993	145	14	to	to	TO
10_1101-2021_01_08_423993	145	15	coordinate	coordinate	VB
10_1101-2021_01_08_423993	145	16	the	the	DT
10_1101-2021_01_08_423993	145	17	phosphate	phosphate	NN
10_1101-2021_01_08_423993	145	18	group	group	NN
10_1101-2021_01_08_423993	145	19	of	of	IN
10_1101-2021_01_08_423993	145	20	the	the	DT
10_1101-2021_01_08_423993	145	21	AMP	AMP	NNP
10_1101-2021_01_08_423993	145	22	in	in	IN
10_1101-2021_01_08_423993	145	23	an	an	DT
10_1101-2021_01_08_423993	145	24	octahedral	octahedral	JJ
10_1101-2021_01_08_423993	145	25	manner	manner	NN
10_1101-2021_01_08_423993	145	26	(	(	-LRB-
10_1101-2021_01_08_423993	145	27	Figure	figure	NN
10_1101-2021_01_08_423993	145	28	2B	2B	NNS
10_1101-2021_01_08_423993	145	29	)	)	-RRB-
10_1101-2021_01_08_423993	145	30	.	.	.
10_1101-2021_01_08_423993	146	1	In	in	IN
10_1101-2021_01_08_423993	146	2	summary	summary	NN
10_1101-2021_01_08_423993	146	3	,	,	,
10_1101-2021_01_08_423993	146	4	the	the	DT
10_1101-2021_01_08_423993	146	5	octahedral	octahedral	JJ
10_1101-2021_01_08_423993	146	6	coordination	coordination	NN
10_1101-2021_01_08_423993	146	7	sites	site	NNS
10_1101-2021_01_08_423993	146	8	for	for	IN
10_1101-2021_01_08_423993	146	9	the	the	DT
10_1101-2021_01_08_423993	146	10	first	first	JJ
10_1101-2021_01_08_423993	146	11	zinc	zinc	NN
10_1101-2021_01_08_423993	146	12	ion	ion	NN
10_1101-2021_01_08_423993	146	13	are	be	VBP
10_1101-2021_01_08_423993	146	14	contributed	contribute	VBN
10_1101-2021_01_08_423993	146	15	to	to	IN
10_1101-2021_01_08_423993	146	16	by	by	IN
10_1101-2021_01_08_423993	146	17	three	three	CD
10_1101-2021_01_08_423993	146	18	histidines	histidine	NNS
10_1101-2021_01_08_423993	146	19	,	,	,
10_1101-2021_01_08_423993	146	20	one	one	CD
10_1101-2021_01_08_423993	146	21	aspartate	aspartate	NN
10_1101-2021_01_08_423993	146	22	residue	residue	NN
10_1101-2021_01_08_423993	146	23	,	,	,
10_1101-2021_01_08_423993	146	24	and	and	CC
10_1101-2021_01_08_423993	146	25	either	either	CC
10_1101-2021_01_08_423993	146	26	water	water	NN
10_1101-2021_01_08_423993	146	27	molecules	molecule	NNS
10_1101-2021_01_08_423993	146	28	or	or	CC
10_1101-2021_01_08_423993	146	29	a	a	DT
10_1101-2021_01_08_423993	146	30	phosphate	phosphate	JJ
10_1101-2021_01_08_423993	146	31	oxygen	oxygen	NN
10_1101-2021_01_08_423993	146	32	of	of	IN
10_1101-2021_01_08_423993	146	33	the	the	DT
10_1101-2021_01_08_423993	146	34	substrate	substrate	NN
10_1101-2021_01_08_423993	146	35	;	;	:
10_1101-2021_01_08_423993	146	36	the	the	DT
10_1101-2021_01_08_423993	146	37	second	second	JJ
10_1101-2021_01_08_423993	146	38	metal	metal	NN
10_1101-2021_01_08_423993	146	39	ion	ion	NN
10_1101-2021_01_08_423993	146	40	is	be	VBZ
10_1101-2021_01_08_423993	146	41	more	more	RBR
10_1101-2021_01_08_423993	146	42	weakly	weakly	RB
10_1101-2021_01_08_423993	146	43	coordinated	coordinate	VBN
10_1101-2021_01_08_423993	146	44	in	in	IN
10_1101-2021_01_08_423993	146	45	the	the	DT
10_1101-2021_01_08_423993	146	46	SNM1	SNM1	NNP
10_1101-2021_01_08_423993	146	47	protein	protein	NN
10_1101-2021_01_08_423993	146	48	family	family	NN
10_1101-2021_01_08_423993	146	49	,	,	,
10_1101-2021_01_08_423993	146	50	with	with	IN
10_1101-2021_01_08_423993	146	51	one	one	CD
10_1101-2021_01_08_423993	146	52	histidine	histidine	NN
10_1101-2021_01_08_423993	146	53	and	and	CC
10_1101-2021_01_08_423993	146	54	two	two	CD
10_1101-2021_01_08_423993	146	55	aspartates	aspartate	NNS
10_1101-2021_01_08_423993	146	56	,	,	,
10_1101-2021_01_08_423993	146	57	with	with	IN
10_1101-2021_01_08_423993	146	58	the	the	DT
10_1101-2021_01_08_423993	146	59	remaining	remain	VBG
10_1101-2021_01_08_423993	146	60	three	three	CD
10_1101-2021_01_08_423993	146	61	positions	position	NNS
10_1101-2021_01_08_423993	146	62	occupied	occupy	VBN
10_1101-2021_01_08_423993	146	63	by	by	IN
10_1101-2021_01_08_423993	146	64	water	water	NN
10_1101-2021_01_08_423993	146	65	or	or	CC
10_1101-2021_01_08_423993	146	66	a	a	DT
10_1101-2021_01_08_423993	146	67	phosphate	phosphate	JJ
10_1101-2021_01_08_423993	146	68	oxygen	oxygen	NN
10_1101-2021_01_08_423993	146	69	of	of	IN
10_1101-2021_01_08_423993	146	70	the	the	DT
10_1101-2021_01_08_423993	146	71	DNA	DNA	NNP
10_1101-2021_01_08_423993	146	72	substrate	substrate	NN
10_1101-2021_01_08_423993	146	73	.	.	.
10_1101-2021_01_08_423993	147	1	This	this	DT
10_1101-2021_01_08_423993	147	2	can	can	MD
10_1101-2021_01_08_423993	147	3	explain	explain	VB
10_1101-2021_01_08_423993	147	4	the	the	DT
10_1101-2021_01_08_423993	147	5	partial	partial	JJ
10_1101-2021_01_08_423993	147	6	occupancy	occupancy	NN
10_1101-2021_01_08_423993	147	7	of	of	IN
10_1101-2021_01_08_423993	147	8	the	the	DT
10_1101-2021_01_08_423993	147	9	second	second	JJ
10_1101-2021_01_08_423993	147	10	zinc	zinc	NN
10_1101-2021_01_08_423993	147	11	position	position	NN
10_1101-2021_01_08_423993	147	12	in	in	IN
10_1101-2021_01_08_423993	147	13	SNM1	SNM1	NNP
10_1101-2021_01_08_423993	147	14	enzyme	enzyme	NNS
10_1101-2021_01_08_423993	147	15	structures	structure	NNS
10_1101-2021_01_08_423993	147	16	,	,	,
10_1101-2021_01_08_423993	147	17	where	where	WRB
10_1101-2021_01_08_423993	147	18	the	the	DT
10_1101-2021_01_08_423993	147	19	full	full	JJ
10_1101-2021_01_08_423993	147	20	occupancy	occupancy	NN
10_1101-2021_01_08_423993	147	21	may	may	MD
10_1101-2021_01_08_423993	147	22	be	be	VB
10_1101-2021_01_08_423993	147	23	achieved	achieve	VBN
10_1101-2021_01_08_423993	147	24	only	only	RB
10_1101-2021_01_08_423993	147	25	in	in	IN
10_1101-2021_01_08_423993	147	26	presence	presence	NN
10_1101-2021_01_08_423993	147	27	of	of	IN
10_1101-2021_01_08_423993	147	28	substrate	substrate	NN
10_1101-2021_01_08_423993	147	29	.	.	.
10_1101-2021_01_08_423993	148	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	148	2	propose	propose	VBP
10_1101-2021_01_08_423993	148	3	that	that	IN
10_1101-2021_01_08_423993	148	4	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	148	5	would	would	MD
10_1101-2021_01_08_423993	148	6	.CC	.CC	:
10_1101-2021_01_08_423993	148	7	-	-	:
10_1101-2021_01_08_423993	148	8	BY	by	IN
10_1101-2021_01_08_423993	148	9	4.0	4.0	CD
10_1101-2021_01_08_423993	148	10	International	international	JJ
10_1101-2021_01_08_423993	148	11	licensemade	licensemade	NN
10_1101-2021_01_08_423993	148	12	available	available	JJ
10_1101-2021_01_08_423993	148	13	under	under	IN
10_1101-2021_01_08_423993	148	14	a	a	DT
10_1101-2021_01_08_423993	148	15	(	(	-LRB-
10_1101-2021_01_08_423993	148	16	which	which	WDT
10_1101-2021_01_08_423993	148	17	was	be	VBD
10_1101-2021_01_08_423993	148	18	not	not	RB
10_1101-2021_01_08_423993	148	19	certified	certify	VBN
10_1101-2021_01_08_423993	148	20	by	by	IN
10_1101-2021_01_08_423993	148	21	peer	peer	NN
10_1101-2021_01_08_423993	148	22	review	review	NN
10_1101-2021_01_08_423993	148	23	)	)	-RRB-
10_1101-2021_01_08_423993	148	24	is	be	VBZ
10_1101-2021_01_08_423993	148	25	the	the	DT
10_1101-2021_01_08_423993	148	26	author	author	NN
10_1101-2021_01_08_423993	148	27	/	/	SYM
10_1101-2021_01_08_423993	148	28	funder	funder	NN
10_1101-2021_01_08_423993	148	29	,	,	,
10_1101-2021_01_08_423993	148	30	who	who	WP
10_1101-2021_01_08_423993	148	31	has	have	VBZ
10_1101-2021_01_08_423993	148	32	granted	grant	VBN
10_1101-2021_01_08_423993	148	33	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	148	34	a	a	DT
10_1101-2021_01_08_423993	148	35	license	license	NN
10_1101-2021_01_08_423993	148	36	to	to	TO
10_1101-2021_01_08_423993	148	37	display	display	VB
10_1101-2021_01_08_423993	148	38	the	the	DT
10_1101-2021_01_08_423993	148	39	preprint	preprint	NN
10_1101-2021_01_08_423993	148	40	in	in	IN
10_1101-2021_01_08_423993	148	41	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	148	42	.	.	.
10_1101-2021_01_08_423993	149	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	149	2	is	be	VBZ
10_1101-2021_01_08_423993	149	3	The	the	DT
10_1101-2021_01_08_423993	149	4	copyright	copyright	NN
10_1101-2021_01_08_423993	149	5	holder	holder	NN
10_1101-2021_01_08_423993	149	6	for	for	IN
10_1101-2021_01_08_423993	149	7	this	this	DT
10_1101-2021_01_08_423993	149	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	149	9	version	version	NN
10_1101-2021_01_08_423993	149	10	posted	post	VBD
10_1101-2021_01_08_423993	149	11	January	January	NNP
10_1101-2021_01_08_423993	149	12	8	8	CD
10_1101-2021_01_08_423993	149	13	,	,	,
10_1101-2021_01_08_423993	149	14	2021	2021	CD
10_1101-2021_01_08_423993	149	15	.	.	.
10_1101-2021_01_08_423993	149	16	;	;	:
10_1101-2021_01_08_423993	149	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	149	18	:	:	:
10_1101-2021_01_08_423993	149	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	149	20	preprint	preprint	NN
10_1101-2021_01_08_423993	149	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	149	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	UH
10_1101-2021_01_08_423993	149	23	coordinate	coordinate	VB
10_1101-2021_01_08_423993	149	24	a	a	DT
10_1101-2021_01_08_423993	149	25	phosphate	phosphate	NN
10_1101-2021_01_08_423993	149	26	group	group	NN
10_1101-2021_01_08_423993	149	27	of	of	IN
10_1101-2021_01_08_423993	149	28	its	-PRON-	PRP$
10_1101-2021_01_08_423993	149	29	substrate	substrate	NN
10_1101-2021_01_08_423993	149	30	in	in	IN
10_1101-2021_01_08_423993	149	31	a	a	DT
10_1101-2021_01_08_423993	149	32	similar	similar	JJ
10_1101-2021_01_08_423993	149	33	manner	manner	NN
10_1101-2021_01_08_423993	149	34	.	.	.
10_1101-2021_01_08_423993	150	1	The	the	DT
10_1101-2021_01_08_423993	150	2	structure	structure	NN
10_1101-2021_01_08_423993	150	3	of	of	IN
10_1101-2021_01_08_423993	150	4	human	human	NN
10_1101-2021_01_08_423993	150	5	CPSF-73	CPSF-73	,
10_1101-2021_01_08_423993	150	6	(	(	-LRB-
10_1101-2021_01_08_423993	150	7	PDB	PDB	NNP
10_1101-2021_01_08_423993	150	8	:	:	:
10_1101-2021_01_08_423993	150	9	2I7	2i7	CD
10_1101-2021_01_08_423993	150	10	T	T	NNP
10_1101-2021_01_08_423993	150	11	)	)	-RRB-
10_1101-2021_01_08_423993	150	12	,	,	,
10_1101-2021_01_08_423993	150	13	an	an	DT
10_1101-2021_01_08_423993	150	14	RNA	RNA	NNP
10_1101-2021_01_08_423993	150	15	processing	processing	NN
10_1101-2021_01_08_423993	150	16	nuclease	nuclease	NN
10_1101-2021_01_08_423993	150	17	,	,	,
10_1101-2021_01_08_423993	150	18	with	with	IN
10_1101-2021_01_08_423993	150	19	two	two	CD
10_1101-2021_01_08_423993	150	20	active	active	JJ
10_1101-2021_01_08_423993	150	21	site	site	NN
10_1101-2021_01_08_423993	150	22	bound	bind	VBD
10_1101-2021_01_08_423993	150	23	zinc	zinc	NN
10_1101-2021_01_08_423993	150	24	ions	ion	NNS
10_1101-2021_01_08_423993	150	25	and	and	CC
10_1101-2021_01_08_423993	150	26	a	a	DT
10_1101-2021_01_08_423993	150	27	phosphate	phosphate	NN
10_1101-2021_01_08_423993	150	28	molecule	molecule	NN
10_1101-2021_01_08_423993	150	29	[	[	-LRB-
10_1101-2021_01_08_423993	150	30	45	45	CD
10_1101-2021_01_08_423993	150	31	]	]	-RRB-
10_1101-2021_01_08_423993	150	32	,	,	,
10_1101-2021_01_08_423993	150	33	shows	show	VBZ
10_1101-2021_01_08_423993	150	34	that	that	IN
10_1101-2021_01_08_423993	150	35	the	the	DT
10_1101-2021_01_08_423993	150	36	two	two	CD
10_1101-2021_01_08_423993	150	37	zinc	zinc	NN
10_1101-2021_01_08_423993	150	38	ions	ion	NNS
10_1101-2021_01_08_423993	150	39	are	be	VBP
10_1101-2021_01_08_423993	150	40	coordinated	coordinate	VBN
10_1101-2021_01_08_423993	150	41	in	in	IN
10_1101-2021_01_08_423993	150	42	a	a	DT
10_1101-2021_01_08_423993	150	43	very	very	RB
10_1101-2021_01_08_423993	150	44	similar	similar	JJ
10_1101-2021_01_08_423993	150	45	geometry	geometry	NN
10_1101-2021_01_08_423993	150	46	with	with	IN
10_1101-2021_01_08_423993	150	47	the	the	DT
10_1101-2021_01_08_423993	150	48	human	human	JJ
10_1101-2021_01_08_423993	150	49	MBL	MBL	NNP
10_1101-2021_01_08_423993	150	50	DNA	DNA	NNP
10_1101-2021_01_08_423993	150	51	processing	processing	NN
10_1101-2021_01_08_423993	150	52	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	150	53	.	.	.
10_1101-2021_01_08_423993	151	1	[	[	-LRB-
10_1101-2021_01_08_423993	151	2	46,47	46,47	CD
10_1101-2021_01_08_423993	151	3	]	]	-RRB-
10_1101-2021_01_08_423993	151	4	.	.	.
10_1101-2021_01_08_423993	152	1	A	a	DT
10_1101-2021_01_08_423993	152	2	striking	striking	JJ
10_1101-2021_01_08_423993	152	3	difference	difference	NN
10_1101-2021_01_08_423993	152	4	between	between	IN
10_1101-2021_01_08_423993	152	5	the	the	DT
10_1101-2021_01_08_423993	152	6	MBL	MBL	NNP
10_1101-2021_01_08_423993	152	7	RNA	RNA	NNP
10_1101-2021_01_08_423993	152	8	and	and	CC
10_1101-2021_01_08_423993	152	9	DNA	DNA	NNP
10_1101-2021_01_08_423993	152	10	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	152	11	is	be	VBZ
10_1101-2021_01_08_423993	152	12	that	that	IN
10_1101-2021_01_08_423993	152	13	the	the	DT
10_1101-2021_01_08_423993	152	14	second	second	JJ
10_1101-2021_01_08_423993	152	15	metal	metal	NN
10_1101-2021_01_08_423993	152	16	ion	ion	NN
10_1101-2021_01_08_423993	152	17	(	(	-LRB-
10_1101-2021_01_08_423993	152	18	M2	M2	NNP
10_1101-2021_01_08_423993	152	19	)	)	-RRB-
10_1101-2021_01_08_423993	152	20	in	in	IN
10_1101-2021_01_08_423993	152	21	the	the	DT
10_1101-2021_01_08_423993	152	22	RNA	RNA	NNP
10_1101-2021_01_08_423993	152	23	processing	processing	NN
10_1101-2021_01_08_423993	152	24	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	152	25	is	be	VBZ
10_1101-2021_01_08_423993	152	26	coordinated	coordinate	VBN
10_1101-2021_01_08_423993	152	27	by	by	IN
10_1101-2021_01_08_423993	152	28	an	an	DT
10_1101-2021_01_08_423993	152	29	additional	additional	JJ
10_1101-2021_01_08_423993	152	30	histidine	histidine	NN
10_1101-2021_01_08_423993	152	31	residue	residue	NN
10_1101-2021_01_08_423993	152	32	(	(	-LRB-
10_1101-2021_01_08_423993	152	33	His418	his418	CD
10_1101-2021_01_08_423993	152	34	for	for	IN
10_1101-2021_01_08_423993	152	35	CPSF-73	cpsf-73	JJ
10_1101-2021_01_08_423993	152	36	)	)	-RRB-
10_1101-2021_01_08_423993	152	37	[	[	-LRB-
10_1101-2021_01_08_423993	152	38	45	45	CD
10_1101-2021_01_08_423993	152	39	]	]	-RRB-
10_1101-2021_01_08_423993	152	40	that	that	WDT
10_1101-2021_01_08_423993	152	41	is	be	VBZ
10_1101-2021_01_08_423993	152	42	absent	absent	JJ
10_1101-2021_01_08_423993	152	43	in	in	IN
10_1101-2021_01_08_423993	152	44	the	the	DT
10_1101-2021_01_08_423993	152	45	DNA	dna	NN
10_1101-2021_01_08_423993	152	46	processing	processing	NN
10_1101-2021_01_08_423993	152	47	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	152	48	(	(	-LRB-
10_1101-2021_01_08_423993	152	49	Figure	figure	NN
10_1101-2021_01_08_423993	152	50	2D	2d	NN
10_1101-2021_01_08_423993	152	51	)	)	-RRB-
10_1101-2021_01_08_423993	152	52	.	.	.
10_1101-2021_01_08_423993	153	1	The	the	DT
10_1101-2021_01_08_423993	153	2	structure	structure	NN
10_1101-2021_01_08_423993	153	3	of	of	IN
10_1101-2021_01_08_423993	153	4	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	153	5	reveals	reveal	VBZ
10_1101-2021_01_08_423993	153	6	a	a	DT
10_1101-2021_01_08_423993	153	7	novel	novel	JJ
10_1101-2021_01_08_423993	153	8	zinc	zinc	NN
10_1101-2021_01_08_423993	153	9	-	-	HYPH
10_1101-2021_01_08_423993	153	10	finger	finger	NN
10_1101-2021_01_08_423993	153	11	like	like	IN
10_1101-2021_01_08_423993	153	12	motif	motif	NN
10_1101-2021_01_08_423993	153	13	in	in	IN
10_1101-2021_01_08_423993	153	14	the	the	DT
10_1101-2021_01_08_423993	153	15	β	β	NNP
10_1101-2021_01_08_423993	153	16	-	-	HYPH
10_1101-2021_01_08_423993	153	17	CASP	CASP	NNP
10_1101-2021_01_08_423993	153	18	domain	domain	NN
10_1101-2021_01_08_423993	153	19	.	.	.
10_1101-2021_01_08_423993	154	1	Proteins	protein	NNS
10_1101-2021_01_08_423993	154	2	with	with	IN
10_1101-2021_01_08_423993	154	3	a	a	DT
10_1101-2021_01_08_423993	154	4	β	β	NN
10_1101-2021_01_08_423993	154	5	-	-	HYPH
10_1101-2021_01_08_423993	154	6	CASP	CASP	NNP
10_1101-2021_01_08_423993	154	7	fold	fold	VB
10_1101-2021_01_08_423993	154	8	form	form	NN
10_1101-2021_01_08_423993	154	9	a	a	DT
10_1101-2021_01_08_423993	154	10	distinct	distinct	JJ
10_1101-2021_01_08_423993	154	11	sub	sub	NN
10_1101-2021_01_08_423993	154	12	-	-	NN
10_1101-2021_01_08_423993	154	13	group	group	NN
10_1101-2021_01_08_423993	154	14	within	within	IN
10_1101-2021_01_08_423993	154	15	the	the	DT
10_1101-2021_01_08_423993	154	16	MBL	MBL	NNP
10_1101-2021_01_08_423993	154	17	-	-	HYPH
10_1101-2021_01_08_423993	154	18	fold	fold	VB
10_1101-2021_01_08_423993	154	19	superfamily	superfamily	RB
10_1101-2021_01_08_423993	154	20	that	that	WDT
10_1101-2021_01_08_423993	154	21	specifically	specifically	RB
10_1101-2021_01_08_423993	154	22	act	act	VBP
10_1101-2021_01_08_423993	154	23	on	on	IN
10_1101-2021_01_08_423993	154	24	nucleic	nucleic	NNP
10_1101-2021_01_08_423993	154	25	acids	acid	NNS
10_1101-2021_01_08_423993	154	26	[	[	-LRB-
10_1101-2021_01_08_423993	154	27	2	2	CD
10_1101-2021_01_08_423993	154	28	]	]	-RRB-
10_1101-2021_01_08_423993	154	29	.	.	.
10_1101-2021_01_08_423993	155	1	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	155	2	’	’	POS
10_1101-2021_01_08_423993	155	3	β	β	NNP
10_1101-2021_01_08_423993	155	4	-	-	HYPH
10_1101-2021_01_08_423993	155	5	CASP	CASP	NNP
10_1101-2021_01_08_423993	155	6	domain	domain	NN
10_1101-2021_01_08_423993	155	7	is	be	VBZ
10_1101-2021_01_08_423993	155	8	comprised	comprise	VBN
10_1101-2021_01_08_423993	155	9	of	of	IN
10_1101-2021_01_08_423993	155	10	residues	residue	NNS
10_1101-2021_01_08_423993	155	11	156–384	156–384	CD
10_1101-2021_01_08_423993	155	12	and	and	CC
10_1101-2021_01_08_423993	155	13	it	-PRON-	PRP
10_1101-2021_01_08_423993	155	14	is	be	VBZ
10_1101-2021_01_08_423993	155	15	the	the	DT
10_1101-2021_01_08_423993	155	16	second	second	JJ
10_1101-2021_01_08_423993	155	17	globular	globular	JJ
10_1101-2021_01_08_423993	155	18	domain	domain	NN
10_1101-2021_01_08_423993	155	19	(	(	-LRB-
10_1101-2021_01_08_423993	155	20	Figure	figure	NN
10_1101-2021_01_08_423993	155	21	1A	1a	NN
10_1101-2021_01_08_423993	155	22	,	,	,
10_1101-2021_01_08_423993	155	23	shown	show	VBN
10_1101-2021_01_08_423993	155	24	in	in	IN
10_1101-2021_01_08_423993	155	25	white	white	NN
10_1101-2021_01_08_423993	155	26	)	)	-RRB-
10_1101-2021_01_08_423993	155	27	in	in	IN
10_1101-2021_01_08_423993	155	28	the	the	DT
10_1101-2021_01_08_423993	155	29	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	155	30	region	region	NN
10_1101-2021_01_08_423993	155	31	;	;	,
10_1101-2021_01_08_423993	155	32	inserted	insert	VBN
10_1101-2021_01_08_423993	155	33	within	within	IN
10_1101-2021_01_08_423993	155	34	the	the	DT
10_1101-2021_01_08_423993	155	35	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	155	36	MBL	MBL	NNP
10_1101-2021_01_08_423993	155	37	fold	fold	VB
10_1101-2021_01_08_423993	155	38	sequence	sequence	NN
10_1101-2021_01_08_423993	155	39	between	between	IN
10_1101-2021_01_08_423993	155	40	the	the	DT
10_1101-2021_01_08_423993	155	41	small	small	JJ
10_1101-2021_01_08_423993	155	42	α	α	NNP
10_1101-2021_01_08_423993	155	43	-	-	HYPH
10_1101-2021_01_08_423993	155	44	helices	helix	NNS
10_1101-2021_01_08_423993	155	45	6	6	CD
10_1101-2021_01_08_423993	155	46	and	and	CC
10_1101-2021_01_08_423993	155	47	7	7	CD
10_1101-2021_01_08_423993	155	48	(	(	-LRB-
10_1101-2021_01_08_423993	155	49	figure	figure	NN
10_1101-2021_01_08_423993	155	50	1	1	CD
10_1101-2021_01_08_423993	155	51	B	b	NN
10_1101-2021_01_08_423993	155	52	)	)	-RRB-
10_1101-2021_01_08_423993	155	53	.	.	.
10_1101-2021_01_08_423993	156	1	The	the	DT
10_1101-2021_01_08_423993	156	2	β	β	NNP
10_1101-2021_01_08_423993	156	3	-	-	HYPH
10_1101-2021_01_08_423993	156	4	CASP	CASP	NNP
10_1101-2021_01_08_423993	156	5	domain	domain	NN
10_1101-2021_01_08_423993	156	6	has	have	VBZ
10_1101-2021_01_08_423993	156	7	been	be	VBN
10_1101-2021_01_08_423993	156	8	proposed	propose	VBN
10_1101-2021_01_08_423993	156	9	to	to	TO
10_1101-2021_01_08_423993	156	10	facilitate	facilitate	VB
10_1101-2021_01_08_423993	156	11	substrate	substrate	JJ
10_1101-2021_01_08_423993	156	12	recognition	recognition	NN
10_1101-2021_01_08_423993	156	13	and	and	CC
10_1101-2021_01_08_423993	156	14	binding	bind	VBG
10_1101-2021_01_08_423993	156	15	in	in	IN
10_1101-2021_01_08_423993	156	16	the	the	DT
10_1101-2021_01_08_423993	156	17	nucleic	nucleic	NN
10_1101-2021_01_08_423993	156	18	acid	acid	NN
10_1101-2021_01_08_423993	156	19	processing	process	VBG
10_1101-2021_01_08_423993	156	20	MBL	MBL	NNP
10_1101-2021_01_08_423993	156	21	fold	fold	RB
10_1101-2021_01_08_423993	156	22	-	-	HYPH
10_1101-2021_01_08_423993	156	23	containing	contain	VBG
10_1101-2021_01_08_423993	156	24	family	family	NN
10_1101-2021_01_08_423993	156	25	of	of	IN
10_1101-2021_01_08_423993	156	26	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	156	27	[	[	-LRB-
10_1101-2021_01_08_423993	156	28	2,48	2,48	CD
10_1101-2021_01_08_423993	156	29	]	]	-RRB-
10_1101-2021_01_08_423993	156	30	.	.	.
10_1101-2021_01_08_423993	157	1	Another	another	DT
10_1101-2021_01_08_423993	157	2	metal	metal	NN
10_1101-2021_01_08_423993	157	3	ion	ion	NN
10_1101-2021_01_08_423993	157	4	coordination	coordination	NN
10_1101-2021_01_08_423993	157	5	site	site	NN
10_1101-2021_01_08_423993	157	6	,	,	,
10_1101-2021_01_08_423993	157	7	unique	unique	JJ
10_1101-2021_01_08_423993	157	8	to	to	IN
10_1101-2021_01_08_423993	157	9	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	157	10	,	,	,
10_1101-2021_01_08_423993	157	11	is	be	VBZ
10_1101-2021_01_08_423993	157	12	present	present	JJ
10_1101-2021_01_08_423993	157	13	in	in	IN
10_1101-2021_01_08_423993	157	14	the	the	DT
10_1101-2021_01_08_423993	157	15	β	β	NNP
10_1101-2021_01_08_423993	157	16	-	-	HYPH
10_1101-2021_01_08_423993	157	17	CASP	CASP	NNP
10_1101-2021_01_08_423993	157	18	domain	domain	NN
10_1101-2021_01_08_423993	157	19	,	,	,
10_1101-2021_01_08_423993	157	20	with	with	IN
10_1101-2021_01_08_423993	157	21	similarity	similarity	NN
10_1101-2021_01_08_423993	157	22	to	to	IN
10_1101-2021_01_08_423993	157	23	the	the	DT
10_1101-2021_01_08_423993	157	24	canonical	canonical	JJ
10_1101-2021_01_08_423993	157	25	Cys2	Cys2	NNP
10_1101-2021_01_08_423993	157	26	His2	His2	NNP
10_1101-2021_01_08_423993	157	27	zinc	zinc	NN
10_1101-2021_01_08_423993	157	28	-	-	HYPH
10_1101-2021_01_08_423993	157	29	finger	finger	NN
10_1101-2021_01_08_423993	157	30	motif	motif	NN
10_1101-2021_01_08_423993	157	31	[	[	-LRB-
10_1101-2021_01_08_423993	157	32	49,50	49,50	CD
10_1101-2021_01_08_423993	157	33	]	]	-RRB-
10_1101-2021_01_08_423993	157	34	.	.	.
10_1101-2021_01_08_423993	158	1	Many	many	JJ
10_1101-2021_01_08_423993	158	2	DNA	dna	NN
10_1101-2021_01_08_423993	158	3	binding	bind	VBG
10_1101-2021_01_08_423993	158	4	proteins	protein	NNS
10_1101-2021_01_08_423993	158	5	,	,	,
10_1101-2021_01_08_423993	158	6	including	include	VBG
10_1101-2021_01_08_423993	158	7	transcription	transcription	NN
10_1101-2021_01_08_423993	158	8	factors	factor	NNS
10_1101-2021_01_08_423993	158	9	and	and	CC
10_1101-2021_01_08_423993	158	10	a	a	DT
10_1101-2021_01_08_423993	158	11	substantial	substantial	JJ
10_1101-2021_01_08_423993	158	12	number	number	NN
10_1101-2021_01_08_423993	158	13	of	of	IN
10_1101-2021_01_08_423993	158	14	DNA	dna	NN
10_1101-2021_01_08_423993	158	15	repair	repair	NN
10_1101-2021_01_08_423993	158	16	factors	factor	NNS
10_1101-2021_01_08_423993	158	17	(	(	-LRB-
10_1101-2021_01_08_423993	158	18	including	include	VBG
10_1101-2021_01_08_423993	158	19	those	those	DT
10_1101-2021_01_08_423993	158	20	involved	involved	JJ
10_1101-2021_01_08_423993	158	21	in	in	IN
10_1101-2021_01_08_423993	158	22	NHEJ	NHEJ	NNP
10_1101-2021_01_08_423993	158	23	)	)	-RRB-
10_1101-2021_01_08_423993	158	24	,	,	,
10_1101-2021_01_08_423993	158	25	possess	possess	VBP
10_1101-2021_01_08_423993	158	26	the	the	DT
10_1101-2021_01_08_423993	158	27	classical	classical	JJ
10_1101-2021_01_08_423993	158	28	Cys2	Cys2	NNP
10_1101-2021_01_08_423993	158	29	His2	His2	NNP
10_1101-2021_01_08_423993	158	30	zinc	zinc	NN
10_1101-2021_01_08_423993	158	31	finger	finger	NN
10_1101-2021_01_08_423993	158	32	motif	motif	NN
10_1101-2021_01_08_423993	158	33	,	,	,
10_1101-2021_01_08_423993	158	34	that	that	WDT
10_1101-2021_01_08_423993	158	35	serves	serve	VBZ
10_1101-2021_01_08_423993	158	36	as	as	IN
10_1101-2021_01_08_423993	158	37	a	a	DT
10_1101-2021_01_08_423993	158	38	structural	structural	JJ
10_1101-2021_01_08_423993	158	39	feature	feature	NN
10_1101-2021_01_08_423993	158	40	stabilising	stabilise	VBG
10_1101-2021_01_08_423993	158	41	the	the	DT
10_1101-2021_01_08_423993	158	42	DNA	dna	NN
10_1101-2021_01_08_423993	158	43	binding	bind	VBG
10_1101-2021_01_08_423993	158	44	domain	domain	NN
10_1101-2021_01_08_423993	158	45	[	[	-LRB-
10_1101-2021_01_08_423993	158	46	49–52	49–52	CD
10_1101-2021_01_08_423993	158	47	]	]	-RRB-
10_1101-2021_01_08_423993	158	48	.	.	.
10_1101-2021_01_08_423993	159	1	A	a	DT
10_1101-2021_01_08_423993	159	2	typical	typical	JJ
10_1101-2021_01_08_423993	159	3	Cys2	Cys2	NNP
10_1101-2021_01_08_423993	159	4	His2	His2	NNP
10_1101-2021_01_08_423993	159	5	zinc	zinc	NN
10_1101-2021_01_08_423993	159	6	coordinating	coordinate	VBG
10_1101-2021_01_08_423993	159	7	finger	finger	NN
10_1101-2021_01_08_423993	159	8	(	(	-LRB-
10_1101-2021_01_08_423993	159	9	Figure	Figure	NNP
10_1101-2021_01_08_423993	159	10	3A	3A	NNP
10_1101-2021_01_08_423993	159	11	)	)	-RRB-
10_1101-2021_01_08_423993	159	12	has	have	VBZ
10_1101-2021_01_08_423993	159	13	a	a	DT
10_1101-2021_01_08_423993	159	14	ββα	ββα	NN
10_1101-2021_01_08_423993	159	15	motif	motif	NN
10_1101-2021_01_08_423993	159	16	,	,	,
10_1101-2021_01_08_423993	159	17	wherein	wherein	WRB
10_1101-2021_01_08_423993	159	18	the	the	DT
10_1101-2021_01_08_423993	159	19	zinc	zinc	NN
10_1101-2021_01_08_423993	159	20	ion	ion	NN
10_1101-2021_01_08_423993	159	21	is	be	VBZ
10_1101-2021_01_08_423993	159	22	coordinated	coordinate	VBN
10_1101-2021_01_08_423993	159	23	between	between	IN
10_1101-2021_01_08_423993	159	24	an	an	DT
10_1101-2021_01_08_423993	159	25	α	α	NNP
10_1101-2021_01_08_423993	159	26	-	-	HYPH
10_1101-2021_01_08_423993	159	27	helix	helix	NN
10_1101-2021_01_08_423993	159	28	and	and	CC
10_1101-2021_01_08_423993	159	29	two	two	CD
10_1101-2021_01_08_423993	159	30	antiparallel	antiparallel	VB
10_1101-2021_01_08_423993	159	31	β	β	NN
10_1101-2021_01_08_423993	159	32	-	-	HYPH
10_1101-2021_01_08_423993	159	33	sheets	sheet	NNS
10_1101-2021_01_08_423993	159	34	.	.	.
10_1101-2021_01_08_423993	160	1	The	the	DT
10_1101-2021_01_08_423993	160	2	zinc	zinc	NN
10_1101-2021_01_08_423993	160	3	ion	ion	NN
10_1101-2021_01_08_423993	160	4	confers	confer	VBZ
10_1101-2021_01_08_423993	160	5	structural	structural	JJ
10_1101-2021_01_08_423993	160	6	stability	stability	NN
10_1101-2021_01_08_423993	160	7	and	and	CC
10_1101-2021_01_08_423993	160	8	hydrophobic	hydrophobic	JJ
10_1101-2021_01_08_423993	160	9	residues	residue	NNS
10_1101-2021_01_08_423993	160	10	located	locate	VBN
10_1101-2021_01_08_423993	160	11	at	at	IN
10_1101-2021_01_08_423993	160	12	the	the	DT
10_1101-2021_01_08_423993	160	13	sides	side	NNS
10_1101-2021_01_08_423993	160	14	of	of	IN
10_1101-2021_01_08_423993	160	15	the	the	DT
10_1101-2021_01_08_423993	160	16	zinc	zinc	NN
10_1101-2021_01_08_423993	160	17	coordination	coordination	NN
10_1101-2021_01_08_423993	160	18	site	site	NN
10_1101-2021_01_08_423993	160	19	enable	enable	VBP
10_1101-2021_01_08_423993	160	20	specific	specific	JJ
10_1101-2021_01_08_423993	160	21	binding	binding	NN
10_1101-2021_01_08_423993	160	22	of	of	IN
10_1101-2021_01_08_423993	160	23	the	the	DT
10_1101-2021_01_08_423993	160	24	zinc	zinc	NN
10_1101-2021_01_08_423993	160	25	finger	finger	NN
10_1101-2021_01_08_423993	160	26	in	in	IN
10_1101-2021_01_08_423993	160	27	the	the	DT
10_1101-2021_01_08_423993	160	28	major	major	JJ
10_1101-2021_01_08_423993	160	29	groove	groove	NN
10_1101-2021_01_08_423993	160	30	of	of	IN
10_1101-2021_01_08_423993	160	31	the	the	DT
10_1101-2021_01_08_423993	160	32	DNA	DNA	NNP
10_1101-2021_01_08_423993	160	33	[	[	-LRB-
10_1101-2021_01_08_423993	160	34	49,50,53,54	49,50,53,54	NNP
10_1101-2021_01_08_423993	160	35	]	]	-RRB-
10_1101-2021_01_08_423993	160	36	.	.	.
10_1101-2021_01_08_423993	161	1	Similar	similar	JJ
10_1101-2021_01_08_423993	161	2	to	to	IN
10_1101-2021_01_08_423993	161	3	the	the	DT
10_1101-2021_01_08_423993	161	4	canonical	canonical	JJ
10_1101-2021_01_08_423993	161	5	Cys2	Cys2	NNP
10_1101-2021_01_08_423993	161	6	His2	His2	NNP
10_1101-2021_01_08_423993	161	7	zinc	zinc	NN
10_1101-2021_01_08_423993	161	8	finger	finger	NN
10_1101-2021_01_08_423993	161	9	motif	motif	NN
10_1101-2021_01_08_423993	161	10	,	,	,
10_1101-2021_01_08_423993	161	11	the	the	DT
10_1101-2021_01_08_423993	161	12	zinc	zinc	NN
10_1101-2021_01_08_423993	161	13	ion	ion	NN
10_1101-2021_01_08_423993	161	14	coordination	coordination	NN
10_1101-2021_01_08_423993	161	15	in	in	IN
10_1101-2021_01_08_423993	161	16	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	161	17	’	’	POS
10_1101-2021_01_08_423993	161	18	β	β	NNP
10_1101-2021_01_08_423993	161	19	-	-	HYPH
10_1101-2021_01_08_423993	161	20	CASP	CASP	NNP
10_1101-2021_01_08_423993	161	21	domain	domain	NN
10_1101-2021_01_08_423993	161	22	adopts	adopt	VBZ
10_1101-2021_01_08_423993	161	23	a	a	DT
10_1101-2021_01_08_423993	161	24	tetrahedral	tetrahedral	JJ
10_1101-2021_01_08_423993	161	25	geometry	geometry	NN
10_1101-2021_01_08_423993	161	26	,	,	,
10_1101-2021_01_08_423993	161	27	with	with	IN
10_1101-2021_01_08_423993	161	28	coordination	coordination	NN
10_1101-2021_01_08_423993	161	29	by	by	IN
10_1101-2021_01_08_423993	161	30	two	two	CD
10_1101-2021_01_08_423993	161	31	cysteine	cysteine	NN
10_1101-2021_01_08_423993	161	32	(	(	-LRB-
10_1101-2021_01_08_423993	161	33	Cys256	cys256	CD
10_1101-2021_01_08_423993	161	34	and	and	CC
10_1101-2021_01_08_423993	161	35	Cys272	cys272	CD
10_1101-2021_01_08_423993	161	36	)	)	-RRB-
10_1101-2021_01_08_423993	161	37	and	and	CC
10_1101-2021_01_08_423993	161	38	two	two	CD
10_1101-2021_01_08_423993	161	39	histidine	histidine	NN
10_1101-2021_01_08_423993	161	40	(	(	-LRB-
10_1101-2021_01_08_423993	161	41	His228	his228	PRP$
10_1101-2021_01_08_423993	161	42	and	and	CC
10_1101-2021_01_08_423993	161	43	His254	his254	ADD
10_1101-2021_01_08_423993	161	44	)	)	-RRB-
10_1101-2021_01_08_423993	161	45	residues	residue	NNS
10_1101-2021_01_08_423993	161	46	(	(	-LRB-
10_1101-2021_01_08_423993	161	47	Figure	figure	NN
10_1101-2021_01_08_423993	161	48	3	3	CD
10_1101-2021_01_08_423993	161	49	B	B	NNP
10_1101-2021_01_08_423993	161	50	)	)	-RRB-
10_1101-2021_01_08_423993	161	51	.	.	.
10_1101-2021_01_08_423993	162	1	However	however	RB
10_1101-2021_01_08_423993	162	2	,	,	,
10_1101-2021_01_08_423993	162	3	in	in	IN
10_1101-2021_01_08_423993	162	4	the	the	DT
10_1101-2021_01_08_423993	162	5	case	case	NN
10_1101-2021_01_08_423993	162	6	of	of	IN
10_1101-2021_01_08_423993	162	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	162	8	the	the	DT
10_1101-2021_01_08_423993	162	9	metal	metal	NN
10_1101-2021_01_08_423993	162	10	ion	ion	NN
10_1101-2021_01_08_423993	162	11	coordination	coordination	NN
10_1101-2021_01_08_423993	162	12	site	site	NN
10_1101-2021_01_08_423993	162	13	is	be	VBZ
10_1101-2021_01_08_423993	162	14	sandwiched	sandwich	VBN
10_1101-2021_01_08_423993	162	15	between	between	IN
10_1101-2021_01_08_423993	162	16	two	two	CD
10_1101-2021_01_08_423993	162	17	β	β	NNS
10_1101-2021_01_08_423993	162	18	-	-	HYPH
10_1101-2021_01_08_423993	162	19	sheets	sheet	NNS
10_1101-2021_01_08_423993	162	20	instead	instead	RB
10_1101-2021_01_08_423993	162	21	of	of	IN
10_1101-2021_01_08_423993	162	22	an	an	DT
10_1101-2021_01_08_423993	162	23	α	α	NNP
10_1101-2021_01_08_423993	162	24	-	-	HYPH
10_1101-2021_01_08_423993	162	25	helix	helix	NN
10_1101-2021_01_08_423993	162	26	and	and	CC
10_1101-2021_01_08_423993	162	27	two	two	CD
10_1101-2021_01_08_423993	162	28	antiparallel	antiparallel	VB
10_1101-2021_01_08_423993	162	29	β	β	NN
10_1101-2021_01_08_423993	162	30	-	-	HYPH
10_1101-2021_01_08_423993	162	31	sheets	sheet	NNS
10_1101-2021_01_08_423993	162	32	.	.	.
10_1101-2021_01_08_423993	163	1	Almost	almost	RB
10_1101-2021_01_08_423993	163	2	all	all	PDT
10_1101-2021_01_08_423993	163	3	the	the	DT
10_1101-2021_01_08_423993	163	4	residues	residue	NNS
10_1101-2021_01_08_423993	163	5	in	in	IN
10_1101-2021_01_08_423993	163	6	the	the	DT
10_1101-2021_01_08_423993	163	7	zinc	zinc	NN
10_1101-2021_01_08_423993	163	8	-	-	HYPH
10_1101-2021_01_08_423993	163	9	finger	finger	NN
10_1101-2021_01_08_423993	163	10	like	like	IN
10_1101-2021_01_08_423993	163	11	motif	motif	NN
10_1101-2021_01_08_423993	163	12	(	(	-LRB-
10_1101-2021_01_08_423993	163	13	His228	his228	UH
10_1101-2021_01_08_423993	163	14	,	,	,
10_1101-2021_01_08_423993	163	15	Cys256	cys256	CD
10_1101-2021_01_08_423993	163	16	,	,	,
10_1101-2021_01_08_423993	163	17	and	and	CC
10_1101-2021_01_08_423993	163	18	Cys227	cys227	CD
10_1101-2021_01_08_423993	163	19	)	)	-RRB-
10_1101-2021_01_08_423993	163	20	are	be	VBP
10_1101-2021_01_08_423993	163	21	unique	unique	JJ
10_1101-2021_01_08_423993	163	22	to	to	IN
10_1101-2021_01_08_423993	163	23	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	163	24	(	(	-LRB-
10_1101-2021_01_08_423993	163	25	sequence	sequence	NN
10_1101-2021_01_08_423993	163	26	alignment	alignment	NN
10_1101-2021_01_08_423993	163	27	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	163	28	.	.	.
10_1101-2021_01_08_423993	164	1	Figure	figure	NN
10_1101-2021_01_08_423993	164	2	2	2	CD
10_1101-2021_01_08_423993	164	3	)	)	-RRB-
10_1101-2021_01_08_423993	164	4	,	,	,
10_1101-2021_01_08_423993	164	5	with	with	IN
10_1101-2021_01_08_423993	164	6	only	only	RB
10_1101-2021_01_08_423993	164	7	His254	his254	CD
10_1101-2021_01_08_423993	164	8	being	be	VBG
10_1101-2021_01_08_423993	164	9	well	well	RB
10_1101-2021_01_08_423993	164	10	conserved	conserve	VBN
10_1101-2021_01_08_423993	164	11	within	within	IN
10_1101-2021_01_08_423993	164	12	the	the	DT
10_1101-2021_01_08_423993	164	13	SNM1-family	SNM1-family	NNP
10_1101-2021_01_08_423993	164	14	.	.	.
10_1101-2021_01_08_423993	165	1	However	however	RB
10_1101-2021_01_08_423993	165	2	,	,	,
10_1101-2021_01_08_423993	165	3	these	these	DT
10_1101-2021_01_08_423993	165	4	four	four	CD
10_1101-2021_01_08_423993	165	5	residues	residue	NNS
10_1101-2021_01_08_423993	165	6	that	that	WDT
10_1101-2021_01_08_423993	165	7	forms	form	VBZ
10_1101-2021_01_08_423993	165	8	the	the	DT
10_1101-2021_01_08_423993	165	9	zinc	zinc	NN
10_1101-2021_01_08_423993	165	10	-	-	HYPH
10_1101-2021_01_08_423993	165	11	finger	finger	NN
10_1101-2021_01_08_423993	165	12	like	like	IN
10_1101-2021_01_08_423993	165	13	motif	motif	NN
10_1101-2021_01_08_423993	165	14	are	be	VBP
10_1101-2021_01_08_423993	165	15	highly	highly	RB
10_1101-2021_01_08_423993	165	16	conserved	conserve	VBN
10_1101-2021_01_08_423993	165	17	in	in	IN
10_1101-2021_01_08_423993	165	18	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	165	19	across	across	IN
10_1101-2021_01_08_423993	165	20	different	different	JJ
10_1101-2021_01_08_423993	165	21	species	specie	NNS
10_1101-2021_01_08_423993	165	22	(	(	-LRB-
10_1101-2021_01_08_423993	165	23	from	from	IN
10_1101-2021_01_08_423993	165	24	human	human	NN
10_1101-2021_01_08_423993	165	25	to	to	IN
10_1101-2021_01_08_423993	165	26	marine	marine	NNP
10_1101-2021_01_08_423993	165	27	sponge	sponge	NNP
10_1101-2021_01_08_423993	165	28	)	)	-RRB-
10_1101-2021_01_08_423993	165	29	,	,	,
10_1101-2021_01_08_423993	165	30	implying	imply	VBG
10_1101-2021_01_08_423993	165	31	functional	functional	JJ
10_1101-2021_01_08_423993	165	32	importance	importance	NN
10_1101-2021_01_08_423993	165	33	(	(	-LRB-
10_1101-2021_01_08_423993	165	34	sequence	sequence	NN
10_1101-2021_01_08_423993	165	35	alignment	alignment	NN
10_1101-2021_01_08_423993	165	36	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	165	37	.	.	.
10_1101-2021_01_08_423993	166	1	Figure	figure	NN
10_1101-2021_01_08_423993	166	2	3	3	CD
10_1101-2021_01_08_423993	166	3	)	)	-RRB-
10_1101-2021_01_08_423993	166	4	.	.	.
10_1101-2021_01_08_423993	167	1	Consistently	consistently	RB
10_1101-2021_01_08_423993	167	2	,	,	,
10_1101-2021_01_08_423993	167	3	substitution	substitution	NN
10_1101-2021_01_08_423993	167	4	of	of	IN
10_1101-2021_01_08_423993	167	5	His228	his228	CD
10_1101-2021_01_08_423993	167	6	and	and	CC
10_1101-2021_01_08_423993	167	7	His254	his254	ADD
10_1101-2021_01_08_423993	167	8	(	(	-LRB-
10_1101-2021_01_08_423993	167	9	H228N	h228n	NN
10_1101-2021_01_08_423993	167	10	and	and	CC
10_1101-2021_01_08_423993	167	11	H254L	h254l	CD
10_1101-2021_01_08_423993	167	12	)	)	-RRB-
10_1101-2021_01_08_423993	167	13	,	,	,
10_1101-2021_01_08_423993	167	14	two	two	CD
10_1101-2021_01_08_423993	167	15	of	of	IN
10_1101-2021_01_08_423993	167	16	the	the	DT
10_1101-2021_01_08_423993	167	17	zinc	zinc	NN
10_1101-2021_01_08_423993	167	18	coordinating	coordinate	VBG
10_1101-2021_01_08_423993	167	19	residues	residue	NNS
10_1101-2021_01_08_423993	167	20	in	in	IN
10_1101-2021_01_08_423993	167	21	the	the	DT
10_1101-2021_01_08_423993	167	22	β	β	NNP
10_1101-2021_01_08_423993	167	23	-	-	HYPH
10_1101-2021_01_08_423993	167	24	CASP	CASP	NNP
10_1101-2021_01_08_423993	167	25	domain	domain	NN
10_1101-2021_01_08_423993	167	26	of	of	IN
10_1101-2021_01_08_423993	167	27	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	167	28	,	,	,
10_1101-2021_01_08_423993	167	29	cause	cause	VB
10_1101-2021_01_08_423993	167	30	RS	RS	NNP
10_1101-2021_01_08_423993	167	31	-	-	HYPH
10_1101-2021_01_08_423993	167	32	SCID	SCID	NNP
10_1101-2021_01_08_423993	167	33	in	in	IN
10_1101-2021_01_08_423993	167	34	humans	human	NNS
10_1101-2021_01_08_423993	167	35	[	[	-LRB-
10_1101-2021_01_08_423993	167	36	34,44,55	34,44,55	NN
10_1101-2021_01_08_423993	167	37	]	]	-RRB-
10_1101-2021_01_08_423993	167	38	.	.	.
10_1101-2021_01_08_423993	168	1	Patients	patient	NNS
10_1101-2021_01_08_423993	168	2	with	with	IN
10_1101-2021_01_08_423993	168	3	these	these	DT
10_1101-2021_01_08_423993	168	4	inherited	inherit	VBN
10_1101-2021_01_08_423993	168	5	mutations	mutation	NNS
10_1101-2021_01_08_423993	168	6	suffer	suffer	VBP
10_1101-2021_01_08_423993	168	7	from	from	IN
10_1101-2021_01_08_423993	168	8	impaired	impaired	JJ
10_1101-2021_01_08_423993	168	9	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	168	10	recombination	recombination	NN
10_1101-2021_01_08_423993	168	11	,	,	,
10_1101-2021_01_08_423993	168	12	leading	lead	VBG
10_1101-2021_01_08_423993	168	13	to	to	IN
10_1101-2021_01_08_423993	168	14	underdeveloped	underdeveloped	JJ
10_1101-2021_01_08_423993	168	15	B	B	NNP
10_1101-2021_01_08_423993	168	16	and	and	CC
10_1101-2021_01_08_423993	168	17	T	T	NNP
10_1101-2021_01_08_423993	168	18	lymphocytes	lymphocyte	NNS
10_1101-2021_01_08_423993	168	19	.	.	.
10_1101-2021_01_08_423993	169	1	The	the	DT
10_1101-2021_01_08_423993	169	2	importance	importance	NN
10_1101-2021_01_08_423993	169	3	of	of	IN
10_1101-2021_01_08_423993	169	4	histidine	histidine	NNP
10_1101-2021_01_08_423993	169	5	254	254	CD
10_1101-2021_01_08_423993	169	6	,	,	,
10_1101-2021_01_08_423993	169	7	has	have	VBZ
10_1101-2021_01_08_423993	169	8	been	be	VBN
10_1101-2021_01_08_423993	169	9	highlighted	highlight	VBN
10_1101-2021_01_08_423993	169	10	by	by	IN
10_1101-2021_01_08_423993	169	11	de	de	NNP
10_1101-2021_01_08_423993	169	12	Villartay	Villartay	NNP
10_1101-2021_01_08_423993	169	13	et	et	FW
10_1101-2021_01_08_423993	169	14	al	al	NNP
10_1101-2021_01_08_423993	169	15	.	.	.
10_1101-2021_01_08_423993	170	1	[	[	-LRB-
10_1101-2021_01_08_423993	170	2	44	44	CD
10_1101-2021_01_08_423993	170	3	]	]	-RRB-
10_1101-2021_01_08_423993	170	4	,	,	,
10_1101-2021_01_08_423993	170	5	who	who	WP
10_1101-2021_01_08_423993	170	6	showed	show	VBD
10_1101-2021_01_08_423993	170	7	that	that	IN
10_1101-2021_01_08_423993	170	8	the	the	DT
10_1101-2021_01_08_423993	170	9	full-	full-	NN
10_1101-2021_01_08_423993	170	10	.CC	.CC	NFP
10_1101-2021_01_08_423993	170	11	-	-	:
10_1101-2021_01_08_423993	170	12	BY	by	IN
10_1101-2021_01_08_423993	170	13	4.0	4.0	CD
10_1101-2021_01_08_423993	170	14	International	international	JJ
10_1101-2021_01_08_423993	170	15	licensemade	licensemade	NN
10_1101-2021_01_08_423993	170	16	available	available	JJ
10_1101-2021_01_08_423993	170	17	under	under	IN
10_1101-2021_01_08_423993	170	18	a	a	DT
10_1101-2021_01_08_423993	170	19	(	(	-LRB-
10_1101-2021_01_08_423993	170	20	which	which	WDT
10_1101-2021_01_08_423993	170	21	was	be	VBD
10_1101-2021_01_08_423993	170	22	not	not	RB
10_1101-2021_01_08_423993	170	23	certified	certify	VBN
10_1101-2021_01_08_423993	170	24	by	by	IN
10_1101-2021_01_08_423993	170	25	peer	peer	NN
10_1101-2021_01_08_423993	170	26	review	review	NN
10_1101-2021_01_08_423993	170	27	)	)	-RRB-
10_1101-2021_01_08_423993	170	28	is	be	VBZ
10_1101-2021_01_08_423993	170	29	the	the	DT
10_1101-2021_01_08_423993	170	30	author	author	NN
10_1101-2021_01_08_423993	170	31	/	/	SYM
10_1101-2021_01_08_423993	170	32	funder	funder	NN
10_1101-2021_01_08_423993	170	33	,	,	,
10_1101-2021_01_08_423993	170	34	who	who	WP
10_1101-2021_01_08_423993	170	35	has	have	VBZ
10_1101-2021_01_08_423993	170	36	granted	grant	VBN
10_1101-2021_01_08_423993	170	37	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	170	38	a	a	DT
10_1101-2021_01_08_423993	170	39	license	license	NN
10_1101-2021_01_08_423993	170	40	to	to	TO
10_1101-2021_01_08_423993	170	41	display	display	VB
10_1101-2021_01_08_423993	170	42	the	the	DT
10_1101-2021_01_08_423993	170	43	preprint	preprint	NN
10_1101-2021_01_08_423993	170	44	in	in	IN
10_1101-2021_01_08_423993	170	45	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	170	46	.	.	.
10_1101-2021_01_08_423993	171	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	171	2	is	be	VBZ
10_1101-2021_01_08_423993	171	3	The	the	DT
10_1101-2021_01_08_423993	171	4	copyright	copyright	NN
10_1101-2021_01_08_423993	171	5	holder	holder	NN
10_1101-2021_01_08_423993	171	6	for	for	IN
10_1101-2021_01_08_423993	171	7	this	this	DT
10_1101-2021_01_08_423993	171	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	171	9	version	version	NN
10_1101-2021_01_08_423993	171	10	posted	post	VBD
10_1101-2021_01_08_423993	171	11	January	January	NNP
10_1101-2021_01_08_423993	171	12	8	8	CD
10_1101-2021_01_08_423993	171	13	,	,	,
10_1101-2021_01_08_423993	171	14	2021	2021	CD
10_1101-2021_01_08_423993	171	15	.	.	.
10_1101-2021_01_08_423993	171	16	;	;	:
10_1101-2021_01_08_423993	171	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	171	18	:	:	:
10_1101-2021_01_08_423993	171	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	171	20	preprint	preprint	NN
10_1101-2021_01_08_423993	171	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	NN
10_1101-2021_01_08_423993	171	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	171	23	length	length	NNP
10_1101-2021_01_08_423993	171	24	H254A	H254A	NNP
10_1101-2021_01_08_423993	171	25	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	171	26	variant	variant	NN
10_1101-2021_01_08_423993	171	27	is	be	VBZ
10_1101-2021_01_08_423993	171	28	unable	unable	JJ
10_1101-2021_01_08_423993	171	29	to	to	TO
10_1101-2021_01_08_423993	171	30	carry	carry	VB
10_1101-2021_01_08_423993	171	31	out	out	RP
10_1101-2021_01_08_423993	171	32	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	171	33	recombination	recombination	NN
10_1101-2021_01_08_423993	171	34	in	in	IN
10_1101-2021_01_08_423993	171	35	vivo	vivo	NNP
10_1101-2021_01_08_423993	171	36	and	and	CC
10_1101-2021_01_08_423993	171	37	has	have	VBZ
10_1101-2021_01_08_423993	171	38	no	no	DT
10_1101-2021_01_08_423993	171	39	discernible	discernible	JJ
10_1101-2021_01_08_423993	171	40	endonucleolytic	endonucleolytic	JJ
10_1101-2021_01_08_423993	171	41	activity	activity	NN
10_1101-2021_01_08_423993	171	42	in	in	IN
10_1101-2021_01_08_423993	171	43	vitro	vitro	FW
10_1101-2021_01_08_423993	171	44	.	.	.
10_1101-2021_01_08_423993	172	1	Comparison	Comparison	NNP
10_1101-2021_01_08_423993	172	2	of	of	IN
10_1101-2021_01_08_423993	172	3	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	172	4	structure	structure	NN
10_1101-2021_01_08_423993	172	5	with	with	IN
10_1101-2021_01_08_423993	172	6	6WO0	6wo0	CD
10_1101-2021_01_08_423993	172	7	and	and	CC
10_1101-2021_01_08_423993	172	8	6WNL	6WNL	VBN
10_1101-2021_01_08_423993	172	9	During	during	IN
10_1101-2021_01_08_423993	172	10	the	the	DT
10_1101-2021_01_08_423993	172	11	preparation	preparation	NN
10_1101-2021_01_08_423993	172	12	of	of	IN
10_1101-2021_01_08_423993	172	13	this	this	DT
10_1101-2021_01_08_423993	172	14	manuscript	manuscript	NN
10_1101-2021_01_08_423993	172	15	a	a	DT
10_1101-2021_01_08_423993	172	16	structural	structural	JJ
10_1101-2021_01_08_423993	172	17	study	study	NN
10_1101-2021_01_08_423993	172	18	on	on	IN
10_1101-2021_01_08_423993	172	19	the	the	DT
10_1101-2021_01_08_423993	172	20	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	172	21	core	core	NN
10_1101-2021_01_08_423993	172	22	of	of	IN
10_1101-2021_01_08_423993	172	23	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	172	24	was	be	VBD
10_1101-2021_01_08_423993	172	25	published	publish	VBN
10_1101-2021_01_08_423993	172	26	[	[	-LRB-
10_1101-2021_01_08_423993	172	27	56	56	CD
10_1101-2021_01_08_423993	172	28	]	]	-RRB-
10_1101-2021_01_08_423993	172	29	.	.	.
10_1101-2021_01_08_423993	173	1	This	this	DT
10_1101-2021_01_08_423993	173	2	study	study	NN
10_1101-2021_01_08_423993	173	3	described	describe	VBD
10_1101-2021_01_08_423993	173	4	reported	report	VBD
10_1101-2021_01_08_423993	173	5	two	two	CD
10_1101-2021_01_08_423993	173	6	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	173	7	structures	structure	NNS
10_1101-2021_01_08_423993	173	8	(	(	-LRB-
10_1101-2021_01_08_423993	173	9	PDB	PDB	NNP
10_1101-2021_01_08_423993	173	10	:	:	:
10_1101-2021_01_08_423993	173	11	6WO0	6wo0	CD
10_1101-2021_01_08_423993	173	12	and	and	CC
10_1101-2021_01_08_423993	173	13	6WNL	6WNL	VBD
10_1101-2021_01_08_423993	173	14	)	)	-RRB-
10_1101-2021_01_08_423993	173	15	that	that	WDT
10_1101-2021_01_08_423993	173	16	are	be	VBP
10_1101-2021_01_08_423993	173	17	similar	similar	JJ
10_1101-2021_01_08_423993	173	18	to	to	IN
10_1101-2021_01_08_423993	173	19	our	-PRON-	PRP$
10_1101-2021_01_08_423993	173	20	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	173	21	structure	structure	NN
10_1101-2021_01_08_423993	173	22	(	(	-LRB-
10_1101-2021_01_08_423993	173	23	PDB	PDB	NNP
10_1101-2021_01_08_423993	173	24	code	code	NN
10_1101-2021_01_08_423993	173	25	7AF1	7af1	CD
10_1101-2021_01_08_423993	173	26	)	)	-RRB-
10_1101-2021_01_08_423993	173	27	(	(	-LRB-
10_1101-2021_01_08_423993	173	28	backbone	backbone	NN
10_1101-2021_01_08_423993	173	29	RMSDs	rmsd	NNS
10_1101-2021_01_08_423993	173	30	of	of	IN
10_1101-2021_01_08_423993	173	31	0.48	0.48	CD
10_1101-2021_01_08_423993	173	32	Å	å	NN
10_1101-2021_01_08_423993	173	33	and	and	CC
10_1101-2021_01_08_423993	173	34	0.54	0.54	CD
10_1101-2021_01_08_423993	173	35	Å	å	NN
10_1101-2021_01_08_423993	173	36	respectively	respectively	RB
10_1101-2021_01_08_423993	173	37	)	)	-RRB-
10_1101-2021_01_08_423993	173	38	,	,	,
10_1101-2021_01_08_423993	173	39	with	with	IN
10_1101-2021_01_08_423993	173	40	identical	identical	JJ
10_1101-2021_01_08_423993	173	41	relative	relative	JJ
10_1101-2021_01_08_423993	173	42	positioning	positioning	NN
10_1101-2021_01_08_423993	173	43	of	of	IN
10_1101-2021_01_08_423993	173	44	the	the	DT
10_1101-2021_01_08_423993	173	45	MBL	MBL	NNP
10_1101-2021_01_08_423993	173	46	and	and	CC
10_1101-2021_01_08_423993	173	47	β	β	NNP
10_1101-2021_01_08_423993	173	48	-	-	HYPH
10_1101-2021_01_08_423993	173	49	CASP	CASP	NNP
10_1101-2021_01_08_423993	173	50	domains	domain	NNS
10_1101-2021_01_08_423993	173	51	(	(	-LRB-
10_1101-2021_01_08_423993	173	52	Figure	figure	NN
10_1101-2021_01_08_423993	173	53	4A	4A	NNS
10_1101-2021_01_08_423993	173	54	and	and	CC
10_1101-2021_01_08_423993	173	55	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	173	56	.	.	.
10_1101-2021_01_08_423993	174	1	Figure	figure	NN
10_1101-2021_01_08_423993	174	2	4A	4A	NNP
10_1101-2021_01_08_423993	174	3	)	)	-RRB-
10_1101-2021_01_08_423993	174	4	.	.	.
10_1101-2021_01_08_423993	175	1	The	the	DT
10_1101-2021_01_08_423993	175	2	only	only	JJ
10_1101-2021_01_08_423993	175	3	significant	significant	JJ
10_1101-2021_01_08_423993	175	4	difference	difference	NN
10_1101-2021_01_08_423993	175	5	was	be	VBD
10_1101-2021_01_08_423993	175	6	that	that	IN
10_1101-2021_01_08_423993	175	7	whilst	whilst	IN
10_1101-2021_01_08_423993	175	8	we	-PRON-	PRP
10_1101-2021_01_08_423993	175	9	refined	refine	VBD
10_1101-2021_01_08_423993	175	10	our	-PRON-	PRP$
10_1101-2021_01_08_423993	175	11	structure	structure	NN
10_1101-2021_01_08_423993	175	12	with	with	IN
10_1101-2021_01_08_423993	175	13	two	two	CD
10_1101-2021_01_08_423993	175	14	zinc	zinc	NN
10_1101-2021_01_08_423993	175	15	ions	ion	NNS
10_1101-2021_01_08_423993	175	16	in	in	IN
10_1101-2021_01_08_423993	175	17	the	the	DT
10_1101-2021_01_08_423993	175	18	active	active	JJ
10_1101-2021_01_08_423993	175	19	site	site	NN
10_1101-2021_01_08_423993	175	20	,	,	,
10_1101-2021_01_08_423993	175	21	both	both	DT
10_1101-2021_01_08_423993	175	22	of	of	IN
10_1101-2021_01_08_423993	175	23	the	the	DT
10_1101-2021_01_08_423993	175	24	crystal	crystal	NN
10_1101-2021_01_08_423993	175	25	forms	form	NNS
10_1101-2021_01_08_423993	175	26	reported	report	VBN
10_1101-2021_01_08_423993	175	27	by	by	IN
10_1101-2021_01_08_423993	175	28	Karim	Karim	NNP
10_1101-2021_01_08_423993	175	29	et	et	NNP
10_1101-2021_01_08_423993	175	30	al	al	NNP
10_1101-2021_01_08_423993	175	31	.	.	.
10_1101-2021_01_08_423993	176	1	were	be	VBD
10_1101-2021_01_08_423993	176	2	modelled	model	VBN
10_1101-2021_01_08_423993	176	3	with	with	IN
10_1101-2021_01_08_423993	176	4	a	a	DT
10_1101-2021_01_08_423993	176	5	single	single	JJ
10_1101-2021_01_08_423993	176	6	active	active	JJ
10_1101-2021_01_08_423993	176	7	site	site	NN
10_1101-2021_01_08_423993	176	8	zinc	zinc	NN
10_1101-2021_01_08_423993	176	9	ion	ion	NN
10_1101-2021_01_08_423993	176	10	(	(	-LRB-
10_1101-2021_01_08_423993	176	11	Zn1	zn1	NN
10_1101-2021_01_08_423993	176	12	)	)	-RRB-
10_1101-2021_01_08_423993	176	13	,	,	,
10_1101-2021_01_08_423993	176	14	reinforcing	reinforce	VBG
10_1101-2021_01_08_423993	176	15	the	the	DT
10_1101-2021_01_08_423993	176	16	proposal	proposal	NN
10_1101-2021_01_08_423993	176	17	of	of	IN
10_1101-2021_01_08_423993	176	18	weaker	weak	JJR
10_1101-2021_01_08_423993	176	19	metal	metal	NN
10_1101-2021_01_08_423993	176	20	ion	ion	NN
10_1101-2021_01_08_423993	176	21	binding	bind	VBG
10_1101-2021_01_08_423993	176	22	at	at	IN
10_1101-2021_01_08_423993	176	23	the	the	DT
10_1101-2021_01_08_423993	176	24	Zn2	Zn2	NNP
10_1101-2021_01_08_423993	176	25	site	site	NN
10_1101-2021_01_08_423993	176	26	.	.	.
10_1101-2021_01_08_423993	177	1	Re	re	NN
10_1101-2021_01_08_423993	177	2	-	-	NN
10_1101-2021_01_08_423993	177	3	analysis	analysis	NN
10_1101-2021_01_08_423993	177	4	of	of	IN
10_1101-2021_01_08_423993	177	5	the	the	DT
10_1101-2021_01_08_423993	177	6	6WO0	6wo0	CD
10_1101-2021_01_08_423993	177	7	and	and	CC
10_1101-2021_01_08_423993	177	8	6WNL	6wnl	JJ
10_1101-2021_01_08_423993	177	9	structures	structure	NNS
10_1101-2021_01_08_423993	177	10	An	an	DT
10_1101-2021_01_08_423993	177	11	unusual	unusual	JJ
10_1101-2021_01_08_423993	177	12	aspect	aspect	NN
10_1101-2021_01_08_423993	177	13	of	of	IN
10_1101-2021_01_08_423993	177	14	the	the	DT
10_1101-2021_01_08_423993	177	15	Karim	Karim	NNP
10_1101-2021_01_08_423993	177	16	et	et	NNP
10_1101-2021_01_08_423993	177	17	al	al	NNP
10_1101-2021_01_08_423993	177	18	.	.	.
10_1101-2021_01_08_423993	178	1	structures	structure	NNS
10_1101-2021_01_08_423993	178	2	is	be	VBZ
10_1101-2021_01_08_423993	178	3	that	that	IN
10_1101-2021_01_08_423993	178	4	both	both	DT
10_1101-2021_01_08_423993	178	5	crystal	crystal	NN
10_1101-2021_01_08_423993	178	6	forms	form	NNS
10_1101-2021_01_08_423993	178	7	were	be	VBD
10_1101-2021_01_08_423993	178	8	obtained	obtain	VBN
10_1101-2021_01_08_423993	178	9	in	in	IN
10_1101-2021_01_08_423993	178	10	the	the	DT
10_1101-2021_01_08_423993	178	11	presence	presence	NN
10_1101-2021_01_08_423993	178	12	of	of	IN
10_1101-2021_01_08_423993	178	13	DNA	dna	NN
10_1101-2021_01_08_423993	178	14	and	and	CC
10_1101-2021_01_08_423993	178	15	were	be	VBD
10_1101-2021_01_08_423993	178	16	reported	report	VBN
10_1101-2021_01_08_423993	178	17	to	to	TO
10_1101-2021_01_08_423993	178	18	require	require	VB
10_1101-2021_01_08_423993	178	19	DNA	dna	NN
10_1101-2021_01_08_423993	178	20	for	for	IN
10_1101-2021_01_08_423993	178	21	their	-PRON-	PRP$
10_1101-2021_01_08_423993	178	22	growth	growth	NN
10_1101-2021_01_08_423993	178	23	;	;	:
10_1101-2021_01_08_423993	178	24	the	the	DT
10_1101-2021_01_08_423993	178	25	crystals	crystal	NNS
10_1101-2021_01_08_423993	178	26	showed	show	VBD
10_1101-2021_01_08_423993	178	27	a	a	DT
10_1101-2021_01_08_423993	178	28	fluorescence	fluorescence	NN
10_1101-2021_01_08_423993	178	29	signal	signal	NN
10_1101-2021_01_08_423993	178	30	supporting	support	VBG
10_1101-2021_01_08_423993	178	31	the	the	DT
10_1101-2021_01_08_423993	178	32	presence	presence	NN
10_1101-2021_01_08_423993	178	33	of	of	IN
10_1101-2021_01_08_423993	178	34	DNA	DNA	NNP
10_1101-2021_01_08_423993	178	35	(	(	-LRB-
10_1101-2021_01_08_423993	178	36	the	the	DT
10_1101-2021_01_08_423993	178	37	oligonucleotides	oligonucleotide	NNS
10_1101-2021_01_08_423993	178	38	used	use	VBN
10_1101-2021_01_08_423993	178	39	contained	contain	VBD
10_1101-2021_01_08_423993	178	40	a	a	DT
10_1101-2021_01_08_423993	178	41	cyanine	cyanine	NN
10_1101-2021_01_08_423993	178	42	dye	dye	NN
10_1101-2021_01_08_423993	178	43	fluorophore	fluorophore	NN
10_1101-2021_01_08_423993	178	44	)	)	-RRB-
10_1101-2021_01_08_423993	178	45	,	,	,
10_1101-2021_01_08_423993	178	46	yet	yet	CC
10_1101-2021_01_08_423993	178	47	neither	neither	DT
10_1101-2021_01_08_423993	178	48	of	of	IN
10_1101-2021_01_08_423993	178	49	the	the	DT
10_1101-2021_01_08_423993	178	50	models	model	NNS
10_1101-2021_01_08_423993	178	51	presented	present	VBN
10_1101-2021_01_08_423993	178	52	contain	contain	VBP
10_1101-2021_01_08_423993	178	53	DNA	dna	NN
10_1101-2021_01_08_423993	178	54	.	.	.
10_1101-2021_01_08_423993	179	1	The	the	DT
10_1101-2021_01_08_423993	179	2	authors	author	NNS
10_1101-2021_01_08_423993	179	3	referred	refer	VBD
10_1101-2021_01_08_423993	179	4	to	to	IN
10_1101-2021_01_08_423993	179	5	some	some	DT
10_1101-2021_01_08_423993	179	6	broken	broken	JJ
10_1101-2021_01_08_423993	179	7	stacking	stack	VBG
10_1101-2021_01_08_423993	179	8	electron	electron	NN
10_1101-2021_01_08_423993	179	9	density	density	NN
10_1101-2021_01_08_423993	179	10	in	in	IN
10_1101-2021_01_08_423993	179	11	6WNL	6WNL	NNP
10_1101-2021_01_08_423993	179	12	in	in	IN
10_1101-2021_01_08_423993	179	13	a	a	DT
10_1101-2021_01_08_423993	179	14	solvent	solvent	NN
10_1101-2021_01_08_423993	179	15	channel	channel	NN
10_1101-2021_01_08_423993	179	16	and	and	CC
10_1101-2021_01_08_423993	179	17	a	a	DT
10_1101-2021_01_08_423993	179	18	patch	patch	NN
10_1101-2021_01_08_423993	179	19	of	of	IN
10_1101-2021_01_08_423993	179	20	unsolved	unsolved	JJ
10_1101-2021_01_08_423993	179	21	density	density	NN
10_1101-2021_01_08_423993	179	22	approaching	approach	VBG
10_1101-2021_01_08_423993	179	23	the	the	DT
10_1101-2021_01_08_423993	179	24	active	active	JJ
10_1101-2021_01_08_423993	179	25	site	site	NN
10_1101-2021_01_08_423993	179	26	in	in	IN
10_1101-2021_01_08_423993	179	27	6WO0	6wo0	CD
10_1101-2021_01_08_423993	179	28	,	,	,
10_1101-2021_01_08_423993	179	29	but	but	CC
10_1101-2021_01_08_423993	179	30	state	state	NN
10_1101-2021_01_08_423993	179	31	that	that	WDT
10_1101-2021_01_08_423993	179	32	the	the	DT
10_1101-2021_01_08_423993	179	33	DNA	DNA	NNP
10_1101-2021_01_08_423993	179	34	“	"	``
10_1101-2021_01_08_423993	179	35	did	do	VBD
10_1101-2021_01_08_423993	179	36	not	not	RB
10_1101-2021_01_08_423993	179	37	bind	bind	VB
10_1101-2021_01_08_423993	179	38	to	to	IN
10_1101-2021_01_08_423993	179	39	the	the	DT
10_1101-2021_01_08_423993	179	40	protein	protein	NN
10_1101-2021_01_08_423993	179	41	in	in	IN
10_1101-2021_01_08_423993	179	42	a	a	DT
10_1101-2021_01_08_423993	179	43	physiological	physiological	JJ
10_1101-2021_01_08_423993	179	44	way	way	NN
10_1101-2021_01_08_423993	179	45	,	,	,
10_1101-2021_01_08_423993	179	46	and	and	CC
10_1101-2021_01_08_423993	179	47	likely	likely	RB
10_1101-2021_01_08_423993	179	48	bound	bind	VBN
10_1101-2021_01_08_423993	179	49	promiscuously	promiscuously	RB
10_1101-2021_01_08_423993	179	50	to	to	TO
10_1101-2021_01_08_423993	179	51	promote	promote	VB
10_1101-2021_01_08_423993	179	52	crystallization	crystallization	NN
10_1101-2021_01_08_423993	179	53	”	"	''
10_1101-2021_01_08_423993	179	54	[	[	-LRB-
10_1101-2021_01_08_423993	179	55	56	56	CD
10_1101-2021_01_08_423993	179	56	]	]	-RRB-
10_1101-2021_01_08_423993	179	57	.	.	.
10_1101-2021_01_08_423993	180	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	180	2	performed	perform	VBD
10_1101-2021_01_08_423993	180	3	a	a	DT
10_1101-2021_01_08_423993	180	4	careful	careful	JJ
10_1101-2021_01_08_423993	180	5	re	re	NN
10_1101-2021_01_08_423993	180	6	-	-	NN
10_1101-2021_01_08_423993	180	7	examination	examination	NN
10_1101-2021_01_08_423993	180	8	of	of	IN
10_1101-2021_01_08_423993	180	9	these	these	DT
10_1101-2021_01_08_423993	180	10	structures	structure	NNS
10_1101-2021_01_08_423993	180	11	looking	look	VBG
10_1101-2021_01_08_423993	180	12	closely	closely	RB
10_1101-2021_01_08_423993	180	13	at	at	IN
10_1101-2021_01_08_423993	180	14	the	the	DT
10_1101-2021_01_08_423993	180	15	residual	residual	JJ
10_1101-2021_01_08_423993	180	16	electron	electron	NNP
10_1101-2021_01_08_423993	180	17	density	density	NN
10_1101-2021_01_08_423993	180	18	.	.	.
10_1101-2021_01_08_423993	181	1	For	for	IN
10_1101-2021_01_08_423993	181	2	the	the	DT
10_1101-2021_01_08_423993	181	3	6WNL	6wnl	JJ
10_1101-2021_01_08_423993	181	4	structure	structure	NN
10_1101-2021_01_08_423993	181	5	we	-PRON-	PRP
10_1101-2021_01_08_423993	181	6	were	be	VBD
10_1101-2021_01_08_423993	181	7	able	able	JJ
10_1101-2021_01_08_423993	181	8	to	to	TO
10_1101-2021_01_08_423993	181	9	locate	locate	VB
10_1101-2021_01_08_423993	181	10	a	a	DT
10_1101-2021_01_08_423993	181	11	distorted	distorted	JJ
10_1101-2021_01_08_423993	181	12	duplex	duplex	NN
10_1101-2021_01_08_423993	181	13	DNA	dna	NN
10_1101-2021_01_08_423993	181	14	of	of	IN
10_1101-2021_01_08_423993	181	15	around	around	IN
10_1101-2021_01_08_423993	181	16	13	13	CD
10_1101-2021_01_08_423993	181	17	base	base	NN
10_1101-2021_01_08_423993	181	18	pairs	pair	NNS
10_1101-2021_01_08_423993	181	19	which	which	WDT
10_1101-2021_01_08_423993	181	20	we	-PRON-	PRP
10_1101-2021_01_08_423993	181	21	propose	propose	VBP
10_1101-2021_01_08_423993	181	22	may	may	MD
10_1101-2021_01_08_423993	181	23	be	be	VB
10_1101-2021_01_08_423993	181	24	the	the	DT
10_1101-2021_01_08_423993	181	25	product	product	NN
10_1101-2021_01_08_423993	181	26	of	of	IN
10_1101-2021_01_08_423993	181	27	duplex	duplex	NN
10_1101-2021_01_08_423993	181	28	annealing	annealing	NN
10_1101-2021_01_08_423993	181	29	of	of	IN
10_1101-2021_01_08_423993	181	30	the	the	DT
10_1101-2021_01_08_423993	181	31	oligonucleotide	oligonucleotide	NN
10_1101-2021_01_08_423993	181	32	used	use	VBN
10_1101-2021_01_08_423993	181	33	for	for	IN
10_1101-2021_01_08_423993	181	34	crystallization	crystallization	NN
10_1101-2021_01_08_423993	181	35	(	(	-LRB-
10_1101-2021_01_08_423993	181	36	a	a	DT
10_1101-2021_01_08_423993	181	37	semi	semi	JJ
10_1101-2021_01_08_423993	181	38	-	-	JJ
10_1101-2021_01_08_423993	181	39	palindromic	palindromic	JJ
10_1101-2021_01_08_423993	181	40	13-mer	13-mer	CD
10_1101-2021_01_08_423993	181	41	that	that	WDT
10_1101-2021_01_08_423993	181	42	was	be	VBD
10_1101-2021_01_08_423993	181	43	designed	design	VBN
10_1101-2021_01_08_423993	181	44	to	to	TO
10_1101-2021_01_08_423993	181	45	form	form	VB
10_1101-2021_01_08_423993	181	46	a	a	DT
10_1101-2021_01_08_423993	181	47	hairpin	hairpin	NN
10_1101-2021_01_08_423993	181	48	with	with	IN
10_1101-2021_01_08_423993	181	49	phospho	phospho	NN
10_1101-2021_01_08_423993	181	50	-	-	HYPH
10_1101-2021_01_08_423993	181	51	thioate	thioate	NN
10_1101-2021_01_08_423993	181	52	linkages	linkage	NNS
10_1101-2021_01_08_423993	181	53	in	in	IN
10_1101-2021_01_08_423993	181	54	the	the	DT
10_1101-2021_01_08_423993	181	55	single	single	RB
10_1101-2021_01_08_423993	181	56	-	-	HYPH
10_1101-2021_01_08_423993	181	57	stranded	strand	VBN
10_1101-2021_01_08_423993	181	58	region	region	NN
10_1101-2021_01_08_423993	181	59	)	)	-RRB-
10_1101-2021_01_08_423993	181	60	(	(	-LRB-
10_1101-2021_01_08_423993	181	61	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	181	62	.	.	.
10_1101-2021_01_08_423993	182	1	Figure	figure	NN
10_1101-2021_01_08_423993	182	2	4B	4b	NN
10_1101-2021_01_08_423993	182	3	)	)	-RRB-
10_1101-2021_01_08_423993	182	4	.	.	.
10_1101-2021_01_08_423993	183	1	For	for	IN
10_1101-2021_01_08_423993	183	2	this	this	DT
10_1101-2021_01_08_423993	183	3	structure	structure	NN
10_1101-2021_01_08_423993	183	4	,	,	,
10_1101-2021_01_08_423993	183	5	we	-PRON-	PRP
10_1101-2021_01_08_423993	183	6	are	be	VBP
10_1101-2021_01_08_423993	183	7	in	in	IN
10_1101-2021_01_08_423993	183	8	general	general	JJ
10_1101-2021_01_08_423993	183	9	agreement	agreement	NN
10_1101-2021_01_08_423993	183	10	with	with	IN
10_1101-2021_01_08_423993	183	11	Karim	Karim	NNP
10_1101-2021_01_08_423993	183	12	et	et	NNP
10_1101-2021_01_08_423993	183	13	al	al	NNP
10_1101-2021_01_08_423993	183	14	that	that	IN
10_1101-2021_01_08_423993	183	15	the	the	DT
10_1101-2021_01_08_423993	183	16	DNA	DNA	NNP
10_1101-2021_01_08_423993	183	17	does	do	VBZ
10_1101-2021_01_08_423993	183	18	not	not	RB
10_1101-2021_01_08_423993	183	19	appear	appear	VB
10_1101-2021_01_08_423993	183	20	to	to	TO
10_1101-2021_01_08_423993	183	21	make	make	VB
10_1101-2021_01_08_423993	183	22	meaningful	meaningful	JJ
10_1101-2021_01_08_423993	183	23	interactions	interaction	NNS
10_1101-2021_01_08_423993	183	24	with	with	IN
10_1101-2021_01_08_423993	183	25	the	the	DT
10_1101-2021_01_08_423993	183	26	protein	protein	NN
10_1101-2021_01_08_423993	183	27	that	that	WDT
10_1101-2021_01_08_423993	183	28	inform	inform	VBP
10_1101-2021_01_08_423993	183	29	on	on	IN
10_1101-2021_01_08_423993	183	30	the	the	DT
10_1101-2021_01_08_423993	183	31	mechanism	mechanism	NN
10_1101-2021_01_08_423993	183	32	of	of	IN
10_1101-2021_01_08_423993	183	33	nuclease	nuclease	NN
10_1101-2021_01_08_423993	183	34	activity	activity	NN
10_1101-2021_01_08_423993	183	35	,	,	,
10_1101-2021_01_08_423993	183	36	although	although	IN
10_1101-2021_01_08_423993	183	37	this	this	DT
10_1101-2021_01_08_423993	183	38	mode	mode	NN
10_1101-2021_01_08_423993	183	39	of	of	IN
10_1101-2021_01_08_423993	183	40	association	association	NN
10_1101-2021_01_08_423993	183	41	with	with	IN
10_1101-2021_01_08_423993	183	42	DNA	DNA	NNP
10_1101-2021_01_08_423993	183	43	may	may	MD
10_1101-2021_01_08_423993	183	44	possibly	possibly	RB
10_1101-2021_01_08_423993	183	45	be	be	VB
10_1101-2021_01_08_423993	183	46	relevant	relevant	JJ
10_1101-2021_01_08_423993	183	47	to	to	TO
10_1101-2021_01_08_423993	183	48	alternative	alternative	VB
10_1101-2021_01_08_423993	183	49	binding	bind	VBG
10_1101-2021_01_08_423993	183	50	modes	mode	NNS
10_1101-2021_01_08_423993	183	51	relating	relate	VBG
10_1101-2021_01_08_423993	183	52	to	to	IN
10_1101-2021_01_08_423993	183	53	higher	high	JJR
10_1101-2021_01_08_423993	183	54	order	order	NN
10_1101-2021_01_08_423993	183	55	complexes	complex	NNS
10_1101-2021_01_08_423993	183	56	containing	contain	VBG
10_1101-2021_01_08_423993	183	57	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	183	58	.	.	.
10_1101-2021_01_08_423993	184	1	By	by	IN
10_1101-2021_01_08_423993	184	2	contrast	contrast	NN
10_1101-2021_01_08_423993	184	3	,	,	,
10_1101-2021_01_08_423993	184	4	for	for	IN
10_1101-2021_01_08_423993	184	5	the	the	DT
10_1101-2021_01_08_423993	184	6	6WO0	6wo0	CD
10_1101-2021_01_08_423993	184	7	structure	structure	NN
10_1101-2021_01_08_423993	184	8	we	-PRON-	PRP
10_1101-2021_01_08_423993	184	9	were	be	VBD
10_1101-2021_01_08_423993	184	10	able	able	JJ
10_1101-2021_01_08_423993	184	11	to	to	TO
10_1101-2021_01_08_423993	184	12	confidently	confidently	RB
10_1101-2021_01_08_423993	184	13	build	build	VB
10_1101-2021_01_08_423993	184	14	a	a	DT
10_1101-2021_01_08_423993	184	15	DNA	dna	NN
10_1101-2021_01_08_423993	184	16	molecule	molecule	NN
10_1101-2021_01_08_423993	184	17	that	that	WDT
10_1101-2021_01_08_423993	184	18	contacts	contact	VBZ
10_1101-2021_01_08_423993	184	19	the	the	DT
10_1101-2021_01_08_423993	184	20	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	184	21	active	active	JJ
10_1101-2021_01_08_423993	184	22	site	site	NN
10_1101-2021_01_08_423993	184	23	in	in	IN
10_1101-2021_01_08_423993	184	24	a	a	DT
10_1101-2021_01_08_423993	184	25	manner	manner	NN
10_1101-2021_01_08_423993	184	26	that	that	WDT
10_1101-2021_01_08_423993	184	27	we	-PRON-	PRP
10_1101-2021_01_08_423993	184	28	believe	believe	VBP
10_1101-2021_01_08_423993	184	29	to	to	TO
10_1101-2021_01_08_423993	184	30	be	be	VB
10_1101-2021_01_08_423993	184	31	relevant	relevant	JJ
10_1101-2021_01_08_423993	184	32	to	to	IN
10_1101-2021_01_08_423993	184	33	the	the	DT
10_1101-2021_01_08_423993	184	34	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	184	35	nuclease	nuclease	NN
10_1101-2021_01_08_423993	184	36	activity	activity	NN
10_1101-2021_01_08_423993	184	37	.	.	.
10_1101-2021_01_08_423993	185	1	Our	-PRON-	PRP$
10_1101-2021_01_08_423993	185	2	model	model	NN
10_1101-2021_01_08_423993	185	3	contains	contain	VBZ
10_1101-2021_01_08_423993	185	4	an	an	DT
10_1101-2021_01_08_423993	185	5	8-nucleotide	8-nucleotide	CD
10_1101-2021_01_08_423993	185	6	5-single	5-single	CD
10_1101-2021_01_08_423993	185	7	-	-	HYPH
10_1101-2021_01_08_423993	185	8	stranded	strand	VBN
10_1101-2021_01_08_423993	185	9	extension	extension	NN
10_1101-2021_01_08_423993	185	10	with	with	IN
10_1101-2021_01_08_423993	185	11	a	a	DT
10_1101-2021_01_08_423993	185	12	short	short	JJ
10_1101-2021_01_08_423993	185	13	2-base	2-base	CD
10_1101-2021_01_08_423993	185	14	pair	pair	NN
10_1101-2021_01_08_423993	185	15	region	region	NN
10_1101-2021_01_08_423993	185	16	of	of	IN
10_1101-2021_01_08_423993	185	17	duplex	duplex	NN
10_1101-2021_01_08_423993	185	18	DNA	DNA	NNP
10_1101-2021_01_08_423993	185	19	that	that	WDT
10_1101-2021_01_08_423993	185	20	reaches	reach	VBZ
10_1101-2021_01_08_423993	185	21	into	into	IN
10_1101-2021_01_08_423993	185	22	the	the	DT
10_1101-2021_01_08_423993	185	23	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	185	24	active	active	JJ
10_1101-2021_01_08_423993	185	25	site	site	NN
10_1101-2021_01_08_423993	185	26	making	make	VBG
10_1101-2021_01_08_423993	185	27	close	close	JJ
10_1101-2021_01_08_423993	185	28	contacts	contact	NNS
10_1101-2021_01_08_423993	185	29	with	with	IN
10_1101-2021_01_08_423993	185	30	the	the	DT
10_1101-2021_01_08_423993	185	31	metal	metal	NN
10_1101-2021_01_08_423993	185	32	ion	ion	NN
10_1101-2021_01_08_423993	185	33	centre	centre	NN
10_1101-2021_01_08_423993	185	34	in	in	IN
10_1101-2021_01_08_423993	185	35	a	a	DT
10_1101-2021_01_08_423993	185	36	manner	manner	NN
10_1101-2021_01_08_423993	185	37	consistent	consistent	JJ
10_1101-2021_01_08_423993	185	38	with	with	IN
10_1101-2021_01_08_423993	185	39	the	the	DT
10_1101-2021_01_08_423993	185	40	proposed	propose	VBN
10_1101-2021_01_08_423993	185	41	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	185	42	mechanism	mechanism	NN
10_1101-2021_01_08_423993	185	43	(	(	-LRB-
10_1101-2021_01_08_423993	185	44	Figure	Figure	NNP
10_1101-2021_01_08_423993	185	45	4B	4b	NN
10_1101-2021_01_08_423993	185	46	)	)	-RRB-
10_1101-2021_01_08_423993	185	47	.	.	.
10_1101-2021_01_08_423993	186	1	The	the	DT
10_1101-2021_01_08_423993	186	2	sequence	sequence	NN
10_1101-2021_01_08_423993	186	3	of	of	IN
10_1101-2021_01_08_423993	186	4	the	the	DT
10_1101-2021_01_08_423993	186	5	longest	long	JJS
10_1101-2021_01_08_423993	186	6	strand	strand	JJ
10_1101-2021_01_08_423993	186	7	corresponds	correspond	VBZ
10_1101-2021_01_08_423993	186	8	to	to	IN
10_1101-2021_01_08_423993	186	9	the	the	DT
10_1101-2021_01_08_423993	186	10	10-nucleotide	10-nucleotide	CD
10_1101-2021_01_08_423993	186	11	cy-5	cy-5	NNP
10_1101-2021_01_08_423993	186	12	labelled	label	VBN
10_1101-2021_01_08_423993	186	13	strand	strand	NNP
10_1101-2021_01_08_423993	186	14	(	(	-LRB-
10_1101-2021_01_08_423993	186	15	cy5-GCGATCAGCT	cy5-GCGATCAGCT	NNP
10_1101-2021_01_08_423993	186	16	)	)	-RRB-
10_1101-2021_01_08_423993	186	17	with	with	IN
10_1101-2021_01_08_423993	186	18	some	some	DT
10_1101-2021_01_08_423993	186	19	residual	residual	JJ
10_1101-2021_01_08_423993	186	20	density	density	NN
10_1101-2021_01_08_423993	186	21	at	at	IN
10_1101-2021_01_08_423993	186	22	the	the	DT
10_1101-2021_01_08_423993	186	23	5-end	5-end	NNP
10_1101-2021_01_08_423993	186	24	that	that	WDT
10_1101-2021_01_08_423993	186	25	may	may	MD
10_1101-2021_01_08_423993	186	26	be	be	VB
10_1101-2021_01_08_423993	186	27	attributed	attribute	VBN
10_1101-2021_01_08_423993	186	28	to	to	IN
10_1101-2021_01_08_423993	186	29	the	the	DT
10_1101-2021_01_08_423993	186	30	cyanine	cyanine	NN
10_1101-2021_01_08_423993	186	31	fluorophore	fluorophore	NN
10_1101-2021_01_08_423993	186	32	which	which	WDT
10_1101-2021_01_08_423993	186	33	we	-PRON-	PRP
10_1101-2021_01_08_423993	186	34	did	do	VBD
10_1101-2021_01_08_423993	186	35	not	not	RB
10_1101-2021_01_08_423993	186	36	include	include	VB
10_1101-2021_01_08_423993	186	37	in	in	IN
10_1101-2021_01_08_423993	186	38	our	-PRON-	PRP$
10_1101-2021_01_08_423993	186	39	model	model	NN
10_1101-2021_01_08_423993	186	40	.	.	.
10_1101-2021_01_08_423993	187	1	The	the	DT
10_1101-2021_01_08_423993	187	2	complementary	complementary	JJ
10_1101-2021_01_08_423993	187	3	.CC	.CC	:
10_1101-2021_01_08_423993	187	4	-	-	:
10_1101-2021_01_08_423993	187	5	BY	by	IN
10_1101-2021_01_08_423993	187	6	4.0	4.0	CD
10_1101-2021_01_08_423993	187	7	International	international	JJ
10_1101-2021_01_08_423993	187	8	licensemade	licensemade	NN
10_1101-2021_01_08_423993	187	9	available	available	JJ
10_1101-2021_01_08_423993	187	10	under	under	IN
10_1101-2021_01_08_423993	187	11	a	a	DT
10_1101-2021_01_08_423993	187	12	(	(	-LRB-
10_1101-2021_01_08_423993	187	13	which	which	WDT
10_1101-2021_01_08_423993	187	14	was	be	VBD
10_1101-2021_01_08_423993	187	15	not	not	RB
10_1101-2021_01_08_423993	187	16	certified	certify	VBN
10_1101-2021_01_08_423993	187	17	by	by	IN
10_1101-2021_01_08_423993	187	18	peer	peer	NN
10_1101-2021_01_08_423993	187	19	review	review	NN
10_1101-2021_01_08_423993	187	20	)	)	-RRB-
10_1101-2021_01_08_423993	187	21	is	be	VBZ
10_1101-2021_01_08_423993	187	22	the	the	DT
10_1101-2021_01_08_423993	187	23	author	author	NN
10_1101-2021_01_08_423993	187	24	/	/	SYM
10_1101-2021_01_08_423993	187	25	funder	funder	NN
10_1101-2021_01_08_423993	187	26	,	,	,
10_1101-2021_01_08_423993	187	27	who	who	WP
10_1101-2021_01_08_423993	187	28	has	have	VBZ
10_1101-2021_01_08_423993	187	29	granted	grant	VBN
10_1101-2021_01_08_423993	187	30	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	187	31	a	a	DT
10_1101-2021_01_08_423993	187	32	license	license	NN
10_1101-2021_01_08_423993	187	33	to	to	TO
10_1101-2021_01_08_423993	187	34	display	display	VB
10_1101-2021_01_08_423993	187	35	the	the	DT
10_1101-2021_01_08_423993	187	36	preprint	preprint	NN
10_1101-2021_01_08_423993	187	37	in	in	IN
10_1101-2021_01_08_423993	187	38	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	187	39	.	.	.
10_1101-2021_01_08_423993	188	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	188	2	is	be	VBZ
10_1101-2021_01_08_423993	188	3	The	the	DT
10_1101-2021_01_08_423993	188	4	copyright	copyright	NN
10_1101-2021_01_08_423993	188	5	holder	holder	NN
10_1101-2021_01_08_423993	188	6	for	for	IN
10_1101-2021_01_08_423993	188	7	this	this	DT
10_1101-2021_01_08_423993	188	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	188	9	version	version	NN
10_1101-2021_01_08_423993	188	10	posted	post	VBD
10_1101-2021_01_08_423993	188	11	January	January	NNP
10_1101-2021_01_08_423993	188	12	8	8	CD
10_1101-2021_01_08_423993	188	13	,	,	,
10_1101-2021_01_08_423993	188	14	2021	2021	CD
10_1101-2021_01_08_423993	188	15	.	.	.
10_1101-2021_01_08_423993	188	16	;	;	:
10_1101-2021_01_08_423993	188	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	188	18	:	:	:
10_1101-2021_01_08_423993	188	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	188	20	preprint	preprint	NN
10_1101-2021_01_08_423993	188	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	NNP
10_1101-2021_01_08_423993	188	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	NNP
10_1101-2021_01_08_423993	188	23	strand	strand	NNP
10_1101-2021_01_08_423993	188	24	used	use	VBN
10_1101-2021_01_08_423993	188	25	for	for	IN
10_1101-2021_01_08_423993	188	26	crystallization	crystallization	NN
10_1101-2021_01_08_423993	188	27	was	be	VBD
10_1101-2021_01_08_423993	188	28	13-nucleotides	13-nucleotides	CD
10_1101-2021_01_08_423993	188	29	long	long	JJ
10_1101-2021_01_08_423993	188	30	and	and	CC
10_1101-2021_01_08_423993	188	31	was	be	VBD
10_1101-2021_01_08_423993	188	32	intended	intend	VBN
10_1101-2021_01_08_423993	188	33	to	to	TO
10_1101-2021_01_08_423993	188	34	produce	produce	VB
10_1101-2021_01_08_423993	188	35	a	a	DT
10_1101-2021_01_08_423993	188	36	5-	5-	CD
10_1101-2021_01_08_423993	188	37	overhang	overhang	NN
10_1101-2021_01_08_423993	188	38	,	,	,
10_1101-2021_01_08_423993	188	39	but	but	CC
10_1101-2021_01_08_423993	188	40	only	only	RB
10_1101-2021_01_08_423993	188	41	two	two	CD
10_1101-2021_01_08_423993	188	42	bases	basis	NNS
10_1101-2021_01_08_423993	188	43	and	and	CC
10_1101-2021_01_08_423993	188	44	three	three	CD
10_1101-2021_01_08_423993	188	45	phosphates	phosphate	NNS
10_1101-2021_01_08_423993	188	46	could	could	MD
10_1101-2021_01_08_423993	188	47	be	be	VB
10_1101-2021_01_08_423993	188	48	located	locate	VBN
10_1101-2021_01_08_423993	188	49	in	in	IN
10_1101-2021_01_08_423993	188	50	the	the	DT
10_1101-2021_01_08_423993	188	51	density	density	NN
10_1101-2021_01_08_423993	188	52	.	.	.
10_1101-2021_01_08_423993	189	1	The	the	DT
10_1101-2021_01_08_423993	189	2	abrupt	abrupt	JJ
10_1101-2021_01_08_423993	189	3	manner	manner	NN
10_1101-2021_01_08_423993	189	4	in	in	IN
10_1101-2021_01_08_423993	189	5	which	which	WDT
10_1101-2021_01_08_423993	189	6	the	the	DT
10_1101-2021_01_08_423993	189	7	electron	electron	NNP
10_1101-2021_01_08_423993	189	8	density	density	NN
10_1101-2021_01_08_423993	189	9	apparently	apparently	RB
10_1101-2021_01_08_423993	189	10	disappears	disappear	VBZ
10_1101-2021_01_08_423993	189	11	from	from	IN
10_1101-2021_01_08_423993	189	12	either	either	DT
10_1101-2021_01_08_423993	189	13	end	end	NN
10_1101-2021_01_08_423993	189	14	of	of	IN
10_1101-2021_01_08_423993	189	15	this	this	DT
10_1101-2021_01_08_423993	189	16	strand	strand	NN
10_1101-2021_01_08_423993	189	17	suggests	suggest	VBZ
10_1101-2021_01_08_423993	189	18	that	that	IN
10_1101-2021_01_08_423993	189	19	this	this	DT
10_1101-2021_01_08_423993	189	20	is	be	VBZ
10_1101-2021_01_08_423993	189	21	the	the	DT
10_1101-2021_01_08_423993	189	22	product	product	NN
10_1101-2021_01_08_423993	189	23	of	of	IN
10_1101-2021_01_08_423993	189	24	a	a	DT
10_1101-2021_01_08_423993	189	25	cleavage	cleavage	NN
10_1101-2021_01_08_423993	189	26	reaction	reaction	NN
10_1101-2021_01_08_423993	189	27	,	,	,
10_1101-2021_01_08_423993	189	28	although	although	IN
10_1101-2021_01_08_423993	189	29	it	-PRON-	PRP
10_1101-2021_01_08_423993	189	30	is	be	VBZ
10_1101-2021_01_08_423993	189	31	possible	possible	JJ
10_1101-2021_01_08_423993	189	32	that	that	IN
10_1101-2021_01_08_423993	189	33	remaining	remain	VBG
10_1101-2021_01_08_423993	189	34	nucleotides	nucleotide	NNS
10_1101-2021_01_08_423993	189	35	are	be	VBP
10_1101-2021_01_08_423993	189	36	not	not	RB
10_1101-2021_01_08_423993	189	37	located	locate	VBN
10_1101-2021_01_08_423993	189	38	due	due	IN
10_1101-2021_01_08_423993	189	39	to	to	IN
10_1101-2021_01_08_423993	189	40	disorder	disorder	NN
10_1101-2021_01_08_423993	189	41	.	.	.
10_1101-2021_01_08_423993	190	1	The	the	DT
10_1101-2021_01_08_423993	190	2	analysis	analysis	NN
10_1101-2021_01_08_423993	190	3	of	of	IN
10_1101-2021_01_08_423993	190	4	electron	electron	NNP
10_1101-2021_01_08_423993	190	5	density	density	NN
10_1101-2021_01_08_423993	190	6	at	at	IN
10_1101-2021_01_08_423993	190	7	this	this	DT
10_1101-2021_01_08_423993	190	8	site	site	NN
10_1101-2021_01_08_423993	190	9	is	be	VBZ
10_1101-2021_01_08_423993	190	10	complicated	complicate	VBN
10_1101-2021_01_08_423993	190	11	by	by	IN
10_1101-2021_01_08_423993	190	12	the	the	DT
10_1101-2021_01_08_423993	190	13	proximity	proximity	NN
10_1101-2021_01_08_423993	190	14	to	to	IN
10_1101-2021_01_08_423993	190	15	a	a	DT
10_1101-2021_01_08_423993	190	16	crystallographic	crystallographic	JJ
10_1101-2021_01_08_423993	190	17	2-fold	2-fold	CD
10_1101-2021_01_08_423993	190	18	symmetry	symmetry	NN
10_1101-2021_01_08_423993	190	19	axis	axis	NNP
10_1101-2021_01_08_423993	190	20	,	,	,
10_1101-2021_01_08_423993	190	21	which	which	WDT
10_1101-2021_01_08_423993	190	22	brings	bring	VBZ
10_1101-2021_01_08_423993	190	23	a	a	DT
10_1101-2021_01_08_423993	190	24	symmetry	symmetry	NN
10_1101-2021_01_08_423993	190	25	copy	copy	NN
10_1101-2021_01_08_423993	190	26	of	of	IN
10_1101-2021_01_08_423993	190	27	the	the	DT
10_1101-2021_01_08_423993	190	28	DNA	DNA	NNP
10_1101-2021_01_08_423993	190	29	molecule	molecule	VB
10_1101-2021_01_08_423993	190	30	into	into	IN
10_1101-2021_01_08_423993	190	31	a	a	DT
10_1101-2021_01_08_423993	190	32	position	position	NN
10_1101-2021_01_08_423993	190	33	where	where	WRB
10_1101-2021_01_08_423993	190	34	atoms	atom	NNS
10_1101-2021_01_08_423993	190	35	partially	partially	RB
10_1101-2021_01_08_423993	190	36	overlap	overlap	VBP
10_1101-2021_01_08_423993	190	37	and	and	CC
10_1101-2021_01_08_423993	190	38	the	the	DT
10_1101-2021_01_08_423993	190	39	extended	extended	JJ
10_1101-2021_01_08_423993	190	40	5	5	CD
10_1101-2021_01_08_423993	190	41	’	'	''
10_1101-2021_01_08_423993	190	42	strands	strand	NNS
10_1101-2021_01_08_423993	190	43	form	form	VB
10_1101-2021_01_08_423993	190	44	a	a	DT
10_1101-2021_01_08_423993	190	45	pseudo	pseudo	NN
10_1101-2021_01_08_423993	190	46	duplex	duplex	NN
10_1101-2021_01_08_423993	190	47	(	(	-LRB-
10_1101-2021_01_08_423993	190	48	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	190	49	.	.	.
10_1101-2021_01_08_423993	191	1	Figure	figure	NN
10_1101-2021_01_08_423993	191	2	5A	5a	NN
10_1101-2021_01_08_423993	191	3	)	)	-RRB-
10_1101-2021_01_08_423993	191	4	.	.	.
10_1101-2021_01_08_423993	192	1	The	the	DT
10_1101-2021_01_08_423993	192	2	occupancy	occupancy	NN
10_1101-2021_01_08_423993	192	3	of	of	IN
10_1101-2021_01_08_423993	192	4	the	the	DT
10_1101-2021_01_08_423993	192	5	entire	entire	JJ
10_1101-2021_01_08_423993	192	6	DNA	dna	NN
10_1101-2021_01_08_423993	192	7	molecule	molecule	NN
10_1101-2021_01_08_423993	192	8	is	be	VBZ
10_1101-2021_01_08_423993	192	9	thus	thus	RB
10_1101-2021_01_08_423993	192	10	limited	limit	VBN
10_1101-2021_01_08_423993	192	11	to	to	IN
10_1101-2021_01_08_423993	192	12	0.5	0.5	CD
10_1101-2021_01_08_423993	192	13	,	,	,
10_1101-2021_01_08_423993	192	14	and	and	CC
10_1101-2021_01_08_423993	192	15	the	the	DT
10_1101-2021_01_08_423993	192	16	lower	low	JJR
10_1101-2021_01_08_423993	192	17	occupancy	occupancy	NN
10_1101-2021_01_08_423993	192	18	is	be	VBZ
10_1101-2021_01_08_423993	192	19	reflected	reflect	VBN
10_1101-2021_01_08_423993	192	20	in	in	IN
10_1101-2021_01_08_423993	192	21	the	the	DT
10_1101-2021_01_08_423993	192	22	electron	electron	NNP
10_1101-2021_01_08_423993	192	23	density	density	NN
10_1101-2021_01_08_423993	192	24	map	map	NN
10_1101-2021_01_08_423993	192	25	which	which	WDT
10_1101-2021_01_08_423993	192	26	requires	require	VBZ
10_1101-2021_01_08_423993	192	27	a	a	DT
10_1101-2021_01_08_423993	192	28	lower	low	JJR
10_1101-2021_01_08_423993	192	29	contour	contour	NN
10_1101-2021_01_08_423993	192	30	level	level	NN
10_1101-2021_01_08_423993	192	31	than	than	IN
10_1101-2021_01_08_423993	192	32	would	would	MD
10_1101-2021_01_08_423993	192	33	usually	usually	RB
10_1101-2021_01_08_423993	192	34	be	be	VB
10_1101-2021_01_08_423993	192	35	applied	apply	VBN
10_1101-2021_01_08_423993	192	36	(	(	-LRB-
10_1101-2021_01_08_423993	192	37	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	192	38	.	.	.
10_1101-2021_01_08_423993	193	1	Figure	figure	NN
10_1101-2021_01_08_423993	193	2	5B	5b	NN
10_1101-2021_01_08_423993	193	3	)	)	-RRB-
10_1101-2021_01_08_423993	193	4	.	.	.
10_1101-2021_01_08_423993	194	1	After	after	IN
10_1101-2021_01_08_423993	194	2	carefully	carefully	RB
10_1101-2021_01_08_423993	194	3	building	build	VBG
10_1101-2021_01_08_423993	194	4	and	and	CC
10_1101-2021_01_08_423993	194	5	refining	refine	VBG
10_1101-2021_01_08_423993	194	6	the	the	DT
10_1101-2021_01_08_423993	194	7	afore	afore	RB
10_1101-2021_01_08_423993	194	8	-	-	HYPH
10_1101-2021_01_08_423993	194	9	described	describe	VBN
10_1101-2021_01_08_423993	194	10	DNA	DNA	NNP
10_1101-2021_01_08_423993	194	11	bound	bind	VBN
10_1101-2021_01_08_423993	194	12	model	model	NN
10_1101-2021_01_08_423993	194	13	,	,	,
10_1101-2021_01_08_423993	194	14	significant	significant	JJ
10_1101-2021_01_08_423993	194	15	positive	positive	JJ
10_1101-2021_01_08_423993	194	16	electron	electron	NN
10_1101-2021_01_08_423993	194	17	density	density	NN
10_1101-2021_01_08_423993	194	18	was	be	VBD
10_1101-2021_01_08_423993	194	19	revealed	reveal	VBN
10_1101-2021_01_08_423993	194	20	for	for	IN
10_1101-2021_01_08_423993	194	21	the	the	DT
10_1101-2021_01_08_423993	194	22	second	second	JJ
10_1101-2021_01_08_423993	194	23	metal	metal	NN
10_1101-2021_01_08_423993	194	24	ion	ion	NN
10_1101-2021_01_08_423993	194	25	(	(	-LRB-
10_1101-2021_01_08_423993	194	26	Zn2	Zn2	NNP
10_1101-2021_01_08_423993	194	27	site	site	NN
10_1101-2021_01_08_423993	194	28	)	)	-RRB-
10_1101-2021_01_08_423993	194	29	which	which	WDT
10_1101-2021_01_08_423993	194	30	we	-PRON-	PRP
10_1101-2021_01_08_423993	194	31	also	also	RB
10_1101-2021_01_08_423993	194	32	included	include	VBD
10_1101-2021_01_08_423993	194	33	in	in	IN
10_1101-2021_01_08_423993	194	34	the	the	DT
10_1101-2021_01_08_423993	194	35	model	model	NN
10_1101-2021_01_08_423993	194	36	with	with	IN
10_1101-2021_01_08_423993	194	37	the	the	DT
10_1101-2021_01_08_423993	194	38	same	same	JJ
10_1101-2021_01_08_423993	194	39	occupancy	occupancy	NN
10_1101-2021_01_08_423993	194	40	(	(	-LRB-
10_1101-2021_01_08_423993	194	41	0.5	0.5	CD
10_1101-2021_01_08_423993	194	42	)	)	-RRB-
10_1101-2021_01_08_423993	194	43	as	as	IN
10_1101-2021_01_08_423993	194	44	the	the	DT
10_1101-2021_01_08_423993	194	45	DNA	DNA	NNP
10_1101-2021_01_08_423993	194	46	.	.	.
10_1101-2021_01_08_423993	195	1	Our	-PRON-	PRP$
10_1101-2021_01_08_423993	195	2	model	model	NN
10_1101-2021_01_08_423993	195	3	was	be	VBD
10_1101-2021_01_08_423993	195	4	refined	refine	VBN
10_1101-2021_01_08_423993	195	5	to	to	IN
10_1101-2021_01_08_423993	195	6	similar	similar	JJ
10_1101-2021_01_08_423993	195	7	crystallographic	crystallographic	JJ
10_1101-2021_01_08_423993	195	8	R-	r-	NN
10_1101-2021_01_08_423993	195	9	factors	factor	NNS
10_1101-2021_01_08_423993	195	10	as	as	IN
10_1101-2021_01_08_423993	195	11	6WO0	6WO0	,
10_1101-2021_01_08_423993	195	12	and	and	CC
10_1101-2021_01_08_423993	195	13	has	have	VBZ
10_1101-2021_01_08_423993	195	14	been	be	VBN
10_1101-2021_01_08_423993	195	15	deposited	deposit	VBN
10_1101-2021_01_08_423993	195	16	with	with	IN
10_1101-2021_01_08_423993	195	17	PDB	pdb	JJ
10_1101-2021_01_08_423993	195	18	accession	accession	NN
10_1101-2021_01_08_423993	195	19	number	number	NN
10_1101-2021_01_08_423993	195	20	7ABS	7abs	JJ
10_1101-2021_01_08_423993	195	21	(	(	-LRB-
10_1101-2021_01_08_423993	195	22	refinement	refinement	JJ
10_1101-2021_01_08_423993	195	23	statistics	statistic	NNS
10_1101-2021_01_08_423993	195	24	are	be	VBP
10_1101-2021_01_08_423993	195	25	given	give	VBN
10_1101-2021_01_08_423993	195	26	in	in	IN
10_1101-2021_01_08_423993	195	27	Table	Table	NNP
10_1101-2021_01_08_423993	195	28	I	I	NNP
10_1101-2021_01_08_423993	195	29	)	)	-RRB-
10_1101-2021_01_08_423993	195	30	.	.	.
10_1101-2021_01_08_423993	196	1	Model	model	NN
10_1101-2021_01_08_423993	196	2	for	for	IN
10_1101-2021_01_08_423993	196	3	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	196	4	DNA	DNA	NNP
10_1101-2021_01_08_423993	196	5	binding	bind	VBG
10_1101-2021_01_08_423993	196	6	Using	use	VBG
10_1101-2021_01_08_423993	196	7	the	the	DT
10_1101-2021_01_08_423993	196	8	crystallographically	crystallographically	RB
10_1101-2021_01_08_423993	196	9	observed	observe	VBN
10_1101-2021_01_08_423993	196	10	DNA	dna	NN
10_1101-2021_01_08_423993	196	11	as	as	IN
10_1101-2021_01_08_423993	196	12	a	a	DT
10_1101-2021_01_08_423993	196	13	template	template	NN
10_1101-2021_01_08_423993	196	14	we	-PRON-	PRP
10_1101-2021_01_08_423993	196	15	were	be	VBD
10_1101-2021_01_08_423993	196	16	able	able	JJ
10_1101-2021_01_08_423993	196	17	make	make	VB
10_1101-2021_01_08_423993	196	18	a	a	DT
10_1101-2021_01_08_423993	196	19	model	model	NN
10_1101-2021_01_08_423993	196	20	for	for	IN
10_1101-2021_01_08_423993	196	21	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	196	22	binding	bind	VBG
10_1101-2021_01_08_423993	196	23	to	to	IN
10_1101-2021_01_08_423993	196	24	a	a	DT
10_1101-2021_01_08_423993	196	25	longer	long	JJR
10_1101-2021_01_08_423993	196	26	section	section	NN
10_1101-2021_01_08_423993	196	27	of	of	IN
10_1101-2021_01_08_423993	196	28	double	double	JJ
10_1101-2021_01_08_423993	196	29	-	-	HYPH
10_1101-2021_01_08_423993	196	30	stranded	strand	VBN
10_1101-2021_01_08_423993	196	31	DNA	dna	NN
10_1101-2021_01_08_423993	196	32	by	by	IN
10_1101-2021_01_08_423993	196	33	complementing	complement	VBG
10_1101-2021_01_08_423993	196	34	unpaired	unpaired	JJ
10_1101-2021_01_08_423993	196	35	bases	basis	NNS
10_1101-2021_01_08_423993	196	36	on	on	IN
10_1101-2021_01_08_423993	196	37	the	the	DT
10_1101-2021_01_08_423993	196	38	single	single	JJ
10_1101-2021_01_08_423993	196	39	-	-	HYPH
10_1101-2021_01_08_423993	196	40	stranded	strand	VBN
10_1101-2021_01_08_423993	196	41	DNA	DNA	NNP
10_1101-2021_01_08_423993	196	42	overhang	overhang	NN
10_1101-2021_01_08_423993	196	43	with	with	IN
10_1101-2021_01_08_423993	196	44	canonical	canonical	JJ
10_1101-2021_01_08_423993	196	45	base	base	NN
10_1101-2021_01_08_423993	196	46	pairs	pair	NNS
10_1101-2021_01_08_423993	196	47	,	,	,
10_1101-2021_01_08_423993	196	48	whilst	whilst	IN
10_1101-2021_01_08_423993	196	49	maintaining	maintain	VBG
10_1101-2021_01_08_423993	196	50	acceptable	acceptable	JJ
10_1101-2021_01_08_423993	196	51	geometry	geometry	NN
10_1101-2021_01_08_423993	196	52	of	of	IN
10_1101-2021_01_08_423993	196	53	the	the	DT
10_1101-2021_01_08_423993	196	54	sugar	sugar	NN
10_1101-2021_01_08_423993	196	55	phosphate	phosphate	NN
10_1101-2021_01_08_423993	196	56	backbone	backbone	NN
10_1101-2021_01_08_423993	196	57	(	(	-LRB-
10_1101-2021_01_08_423993	196	58	Figure	figure	NN
10_1101-2021_01_08_423993	196	59	5A	5a	RB
10_1101-2021_01_08_423993	196	60	)	)	-RRB-
10_1101-2021_01_08_423993	196	61	.	.	.
10_1101-2021_01_08_423993	197	1	The	the	DT
10_1101-2021_01_08_423993	197	2	duplex	duplex	NN
10_1101-2021_01_08_423993	197	3	section	section	NN
10_1101-2021_01_08_423993	197	4	of	of	IN
10_1101-2021_01_08_423993	197	5	this	this	DT
10_1101-2021_01_08_423993	197	6	model	model	NN
10_1101-2021_01_08_423993	197	7	deviates	deviate	VBZ
10_1101-2021_01_08_423993	197	8	slightly	slightly	RB
10_1101-2021_01_08_423993	197	9	from	from	IN
10_1101-2021_01_08_423993	197	10	the	the	DT
10_1101-2021_01_08_423993	197	11	ideal	ideal	JJ
10_1101-2021_01_08_423993	197	12	B	b	NN
10_1101-2021_01_08_423993	197	13	-	-	HYPH
10_1101-2021_01_08_423993	197	14	form	form	NN
10_1101-2021_01_08_423993	197	15	geometry	geometry	NN
10_1101-2021_01_08_423993	197	16	[	[	-LRB-
10_1101-2021_01_08_423993	197	17	57	57	CD
10_1101-2021_01_08_423993	197	18	]	]	-RRB-
10_1101-2021_01_08_423993	197	19	,	,	,
10_1101-2021_01_08_423993	197	20	in	in	IN
10_1101-2021_01_08_423993	197	21	a	a	DT
10_1101-2021_01_08_423993	197	22	manner	manner	NN
10_1101-2021_01_08_423993	197	23	that	that	WDT
10_1101-2021_01_08_423993	197	24	is	be	VBZ
10_1101-2021_01_08_423993	197	25	reminiscent	reminiscent	JJ
10_1101-2021_01_08_423993	197	26	of	of	IN
10_1101-2021_01_08_423993	197	27	certain	certain	JJ
10_1101-2021_01_08_423993	197	28	transcription	transcription	NN
10_1101-2021_01_08_423993	197	29	factor	factor	NN
10_1101-2021_01_08_423993	197	30	DNA	dna	NN
10_1101-2021_01_08_423993	197	31	complexes	complex	NNS
10_1101-2021_01_08_423993	197	32	[	[	-LRB-
10_1101-2021_01_08_423993	197	33	58,59	58,59	CD
10_1101-2021_01_08_423993	197	34	]	]	-RRB-
10_1101-2021_01_08_423993	197	35	.	.	.
10_1101-2021_01_08_423993	198	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	198	2	have	have	VBP
10_1101-2021_01_08_423993	198	3	also	also	RB
10_1101-2021_01_08_423993	198	4	extended	extend	VBN
10_1101-2021_01_08_423993	198	5	the	the	DT
10_1101-2021_01_08_423993	198	6	metal	metal	NN
10_1101-2021_01_08_423993	198	7	ion	ion	NN
10_1101-2021_01_08_423993	198	8	contacting	contact	VBG
10_1101-2021_01_08_423993	198	9	strand	strand	NN
10_1101-2021_01_08_423993	198	10	by	by	IN
10_1101-2021_01_08_423993	198	11	three	three	CD
10_1101-2021_01_08_423993	198	12	nucleotides	nucleotide	NNS
10_1101-2021_01_08_423993	198	13	to	to	TO
10_1101-2021_01_08_423993	198	14	form	form	VB
10_1101-2021_01_08_423993	198	15	a	a	DT
10_1101-2021_01_08_423993	198	16	5-overhang	5-overhang	CD
10_1101-2021_01_08_423993	198	17	;	;	:
10_1101-2021_01_08_423993	198	18	the	the	DT
10_1101-2021_01_08_423993	198	19	positioning	positioning	NN
10_1101-2021_01_08_423993	198	20	of	of	IN
10_1101-2021_01_08_423993	198	21	the	the	DT
10_1101-2021_01_08_423993	198	22	overhang	overhang	NN
10_1101-2021_01_08_423993	198	23	nucleotides	nucleotide	VBZ
10_1101-2021_01_08_423993	198	24	is	be	VBZ
10_1101-2021_01_08_423993	198	25	more	more	RBR
10_1101-2021_01_08_423993	198	26	speculative	speculative	JJ
10_1101-2021_01_08_423993	198	27	,	,	,
10_1101-2021_01_08_423993	198	28	nevertheless	nevertheless	RB
10_1101-2021_01_08_423993	198	29	it	-PRON-	PRP
10_1101-2021_01_08_423993	198	30	was	be	VBD
10_1101-2021_01_08_423993	198	31	possible	possible	JJ
10_1101-2021_01_08_423993	198	32	to	to	TO
10_1101-2021_01_08_423993	198	33	avoid	avoid	VB
10_1101-2021_01_08_423993	198	34	clashes	clash	NNS
10_1101-2021_01_08_423993	198	35	with	with	IN
10_1101-2021_01_08_423993	198	36	protein	protein	NN
10_1101-2021_01_08_423993	198	37	residues	residue	NNS
10_1101-2021_01_08_423993	198	38	whist	whist	NNP
10_1101-2021_01_08_423993	198	39	maintaining	maintain	VBG
10_1101-2021_01_08_423993	198	40	relaxed	relax	VBN
10_1101-2021_01_08_423993	198	41	geometry	geometry	NN
10_1101-2021_01_08_423993	198	42	(	(	-LRB-
10_1101-2021_01_08_423993	198	43	Figure	figure	NN
10_1101-2021_01_08_423993	198	44	6C	6c	NN
10_1101-2021_01_08_423993	198	45	)	)	-RRB-
10_1101-2021_01_08_423993	198	46	.	.	.
10_1101-2021_01_08_423993	199	1	In	in	IN
10_1101-2021_01_08_423993	199	2	the	the	DT
10_1101-2021_01_08_423993	199	3	extended	extended	JJ
10_1101-2021_01_08_423993	199	4	DNA	dna	NN
10_1101-2021_01_08_423993	199	5	complex	complex	JJ
10_1101-2021_01_08_423993	199	6	model	model	NN
10_1101-2021_01_08_423993	199	7	,	,	,
10_1101-2021_01_08_423993	199	8	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	199	9	contacts	contact	VBZ
10_1101-2021_01_08_423993	199	10	both	both	DT
10_1101-2021_01_08_423993	199	11	strands	strand	NNS
10_1101-2021_01_08_423993	199	12	of	of	IN
10_1101-2021_01_08_423993	199	13	the	the	DT
10_1101-2021_01_08_423993	199	14	DNA	dna	NN
10_1101-2021_01_08_423993	199	15	model	model	NN
10_1101-2021_01_08_423993	199	16	in	in	IN
10_1101-2021_01_08_423993	199	17	several	several	JJ
10_1101-2021_01_08_423993	199	18	areas	area	NNS
10_1101-2021_01_08_423993	199	19	;	;	:
10_1101-2021_01_08_423993	199	20	notably	notably	RB
10_1101-2021_01_08_423993	199	21	a	a	DT
10_1101-2021_01_08_423993	199	22	single	single	JJ
10_1101-2021_01_08_423993	199	23	phosphate	phosphate	NN
10_1101-2021_01_08_423993	199	24	lies	lie	NNS
10_1101-2021_01_08_423993	199	25	above	above	IN
10_1101-2021_01_08_423993	199	26	the	the	DT
10_1101-2021_01_08_423993	199	27	di	di	JJ
10_1101-2021_01_08_423993	199	28	-	-	HYPH
10_1101-2021_01_08_423993	199	29	metal	metal	JJ
10_1101-2021_01_08_423993	199	30	ion	ion	NN
10_1101-2021_01_08_423993	199	31	bearing	bear	VBG
10_1101-2021_01_08_423993	199	32	active	active	JJ
10_1101-2021_01_08_423993	199	33	site	site	NN
10_1101-2021_01_08_423993	199	34	and	and	CC
10_1101-2021_01_08_423993	199	35	ligates	ligate	VBZ
10_1101-2021_01_08_423993	199	36	to	to	IN
10_1101-2021_01_08_423993	199	37	both	both	DT
10_1101-2021_01_08_423993	199	38	metal	metal	NN
10_1101-2021_01_08_423993	199	39	ions	ion	NNS
10_1101-2021_01_08_423993	199	40	in	in	IN
10_1101-2021_01_08_423993	199	41	the	the	DT
10_1101-2021_01_08_423993	199	42	same	same	JJ
10_1101-2021_01_08_423993	199	43	manner	manner	NN
10_1101-2021_01_08_423993	199	44	as	as	IN
10_1101-2021_01_08_423993	199	45	observed	observe	VBN
10_1101-2021_01_08_423993	199	46	in	in	IN
10_1101-2021_01_08_423993	199	47	structures	structure	NNS
10_1101-2021_01_08_423993	199	48	of	of	IN
10_1101-2021_01_08_423993	199	49	related	related	JJ
10_1101-2021_01_08_423993	199	50	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	199	51	with	with	IN
10_1101-2021_01_08_423993	199	52	phosphate	phosphate	NN
10_1101-2021_01_08_423993	199	53	or	or	CC
10_1101-2021_01_08_423993	199	54	phosphate	phosphate	NN
10_1101-2021_01_08_423993	199	55	-	-	HYPH
10_1101-2021_01_08_423993	199	56	containing	contain	VBG
10_1101-2021_01_08_423993	199	57	compounds	compound	NNS
10_1101-2021_01_08_423993	199	58	(	(	-LRB-
10_1101-2021_01_08_423993	199	59	Baddock	baddock	IN
10_1101-2021_01_08_423993	199	60	et.al	et.al	NNS
10_1101-2021_01_08_423993	199	61	.	.	.
10_1101-2021_01_08_423993	200	1	2020	2020	CD
10_1101-2021_01_08_423993	200	2	)	)	-RRB-
10_1101-2021_01_08_423993	200	3	[	[	-LRB-
10_1101-2021_01_08_423993	200	4	60	60	CD
10_1101-2021_01_08_423993	200	5	]	]	-RRB-
10_1101-2021_01_08_423993	200	6	.	.	.
10_1101-2021_01_08_423993	201	1	The	the	DT
10_1101-2021_01_08_423993	201	2	two	two	CD
10_1101-2021_01_08_423993	201	3	downstream	downstream	JJ
10_1101-2021_01_08_423993	201	4	nucleotides	nucleotide	NNS
10_1101-2021_01_08_423993	201	5	on	on	IN
10_1101-2021_01_08_423993	201	6	this	this	DT
10_1101-2021_01_08_423993	201	7	strand	strand	NN
10_1101-2021_01_08_423993	201	8	pass	pass	VB
10_1101-2021_01_08_423993	201	9	close	close	RB
10_1101-2021_01_08_423993	201	10	to	to	IN
10_1101-2021_01_08_423993	201	11	the	the	DT
10_1101-2021_01_08_423993	201	12	protein	protein	NN
10_1101-2021_01_08_423993	201	13	surface	surface	NN
10_1101-2021_01_08_423993	201	14	,	,	,
10_1101-2021_01_08_423993	201	15	forming	form	VBG
10_1101-2021_01_08_423993	201	16	possible	possible	JJ
10_1101-2021_01_08_423993	201	17	interactions	interaction	NNS
10_1101-2021_01_08_423993	201	18	with	with	IN
10_1101-2021_01_08_423993	201	19	both	both	CC
10_1101-2021_01_08_423993	201	20	the	the	DT
10_1101-2021_01_08_423993	201	21	main	main	JJ
10_1101-2021_01_08_423993	201	22	chain	chain	NN
10_1101-2021_01_08_423993	201	23	of	of	IN
10_1101-2021_01_08_423993	201	24	Asp37	Asp37	NNP
10_1101-2021_01_08_423993	201	25	and	and	CC
10_1101-2021_01_08_423993	201	26	sidechain	sidechain	NN
10_1101-2021_01_08_423993	201	27	of	of	IN
10_1101-2021_01_08_423993	201	28	Lys36	Lys36	NNP
10_1101-2021_01_08_423993	201	29	,	,	,
10_1101-2021_01_08_423993	201	30	whilst	whilst	IN
10_1101-2021_01_08_423993	201	31	subsequent	subsequent	JJ
10_1101-2021_01_08_423993	201	32	nucleotides	nucleotide	NNS
10_1101-2021_01_08_423993	201	33	are	be	VBP
10_1101-2021_01_08_423993	201	34	not	not	RB
10_1101-2021_01_08_423993	201	35	close	close	JJ
10_1101-2021_01_08_423993	201	36	to	to	IN
10_1101-2021_01_08_423993	201	37	the	the	DT
10_1101-2021_01_08_423993	201	38	protein	protein	NN
10_1101-2021_01_08_423993	201	39	(	(	-LRB-
10_1101-2021_01_08_423993	201	40	Figure	figure	NN
10_1101-2021_01_08_423993	201	41	6A	6a	NN
10_1101-2021_01_08_423993	201	42	)	)	-RRB-
10_1101-2021_01_08_423993	201	43	.	.	.
10_1101-2021_01_08_423993	202	1	The	the	DT
10_1101-2021_01_08_423993	202	2	overhang	overhang	NN
10_1101-2021_01_08_423993	202	3	portion	portion	NN
10_1101-2021_01_08_423993	202	4	of	of	IN
10_1101-2021_01_08_423993	202	5	this	this	DT
10_1101-2021_01_08_423993	202	6	strand	strand	NN
10_1101-2021_01_08_423993	202	7	continues	continue	VBZ
10_1101-2021_01_08_423993	202	8	with	with	IN
10_1101-2021_01_08_423993	202	9	a	a	DT
10_1101-2021_01_08_423993	202	10	slightly	slightly	RB
10_1101-2021_01_08_423993	202	11	altered	alter	VBN
10_1101-2021_01_08_423993	202	12	trajectory	trajectory	CD
10_1101-2021_01_08_423993	202	13	,	,	,
10_1101-2021_01_08_423993	202	14	potentially	potentially	RB
10_1101-2021_01_08_423993	202	15	contacting	contact	VBG
10_1101-2021_01_08_423993	202	16	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	202	17	in	in	IN
10_1101-2021_01_08_423993	202	18	the	the	DT
10_1101-2021_01_08_423993	202	19	vicinity	vicinity	NN
10_1101-2021_01_08_423993	202	20	of	of	IN
10_1101-2021_01_08_423993	202	21	the	the	DT
10_1101-2021_01_08_423993	202	22	cleft	cleft	NNS
10_1101-2021_01_08_423993	202	23	separating	separate	VBG
10_1101-2021_01_08_423993	202	24	the	the	DT
10_1101-2021_01_08_423993	202	25	MBL	MBL	NNP
10_1101-2021_01_08_423993	202	26	and	and	CC
10_1101-2021_01_08_423993	202	27	β	β	NNP
10_1101-2021_01_08_423993	202	28	-	-	HYPH
10_1101-2021_01_08_423993	202	29	CASP	CASP	NNP
10_1101-2021_01_08_423993	202	30	domains	domain	NNS
10_1101-2021_01_08_423993	202	31	,	,	,
10_1101-2021_01_08_423993	202	32	with	with	IN
10_1101-2021_01_08_423993	202	33	the	the	DT
10_1101-2021_01_08_423993	202	34	potential	potential	NN
10_1101-2021_01_08_423993	202	35	to	to	TO
10_1101-2021_01_08_423993	202	36	form	form	VB
10_1101-2021_01_08_423993	202	37	favourable	favourable	JJ
10_1101-2021_01_08_423993	202	38	interactions	interaction	NNS
10_1101-2021_01_08_423993	202	39	with	with	IN
10_1101-2021_01_08_423993	202	40	both	both	DT
10_1101-2021_01_08_423993	202	41	positively	positively	RB
10_1101-2021_01_08_423993	202	42	charged	charge	VBN
10_1101-2021_01_08_423993	202	43	(	(	-LRB-
10_1101-2021_01_08_423993	202	44	Arg	Arg	NNP
10_1101-2021_01_08_423993	202	45	172	172	CD
10_1101-2021_01_08_423993	202	46	)	)	-RRB-
10_1101-2021_01_08_423993	202	47	and	and	CC
10_1101-2021_01_08_423993	202	48	aromatic	aromatic	JJ
10_1101-2021_01_08_423993	202	49	residues	residue	NNS
10_1101-2021_01_08_423993	202	50	(	(	-LRB-
10_1101-2021_01_08_423993	202	51	Phe	Phe	NNP
10_1101-2021_01_08_423993	202	52	173	173	CD
10_1101-2021_01_08_423993	202	53	and	and	CC
10_1101-2021_01_08_423993	202	54	Trp	Trp	NNP
10_1101-2021_01_08_423993	202	55	293	293	CD
10_1101-2021_01_08_423993	202	56	)	)	-RRB-
10_1101-2021_01_08_423993	202	57	(	(	-LRB-
10_1101-2021_01_08_423993	202	58	Figure	figure	NN
10_1101-2021_01_08_423993	202	59	6C	6c	NN
10_1101-2021_01_08_423993	202	60	)	)	-RRB-
10_1101-2021_01_08_423993	202	61	.	.	.
10_1101-2021_01_08_423993	203	1	.CC	.CC	NFP
10_1101-2021_01_08_423993	203	2	-	-	:
10_1101-2021_01_08_423993	203	3	BY	by	IN
10_1101-2021_01_08_423993	203	4	4.0	4.0	CD
10_1101-2021_01_08_423993	203	5	International	international	JJ
10_1101-2021_01_08_423993	203	6	licensemade	licensemade	NN
10_1101-2021_01_08_423993	203	7	available	available	JJ
10_1101-2021_01_08_423993	203	8	under	under	IN
10_1101-2021_01_08_423993	203	9	a	a	DT
10_1101-2021_01_08_423993	203	10	(	(	-LRB-
10_1101-2021_01_08_423993	203	11	which	which	WDT
10_1101-2021_01_08_423993	203	12	was	be	VBD
10_1101-2021_01_08_423993	203	13	not	not	RB
10_1101-2021_01_08_423993	203	14	certified	certify	VBN
10_1101-2021_01_08_423993	203	15	by	by	IN
10_1101-2021_01_08_423993	203	16	peer	peer	NN
10_1101-2021_01_08_423993	203	17	review	review	NN
10_1101-2021_01_08_423993	203	18	)	)	-RRB-
10_1101-2021_01_08_423993	203	19	is	be	VBZ
10_1101-2021_01_08_423993	203	20	the	the	DT
10_1101-2021_01_08_423993	203	21	author	author	NN
10_1101-2021_01_08_423993	203	22	/	/	SYM
10_1101-2021_01_08_423993	203	23	funder	funder	NN
10_1101-2021_01_08_423993	203	24	,	,	,
10_1101-2021_01_08_423993	203	25	who	who	WP
10_1101-2021_01_08_423993	203	26	has	have	VBZ
10_1101-2021_01_08_423993	203	27	granted	grant	VBN
10_1101-2021_01_08_423993	203	28	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	203	29	a	a	DT
10_1101-2021_01_08_423993	203	30	license	license	NN
10_1101-2021_01_08_423993	203	31	to	to	TO
10_1101-2021_01_08_423993	203	32	display	display	VB
10_1101-2021_01_08_423993	203	33	the	the	DT
10_1101-2021_01_08_423993	203	34	preprint	preprint	NN
10_1101-2021_01_08_423993	203	35	in	in	IN
10_1101-2021_01_08_423993	203	36	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	203	37	.	.	.
10_1101-2021_01_08_423993	204	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	204	2	is	be	VBZ
10_1101-2021_01_08_423993	204	3	The	the	DT
10_1101-2021_01_08_423993	204	4	copyright	copyright	NN
10_1101-2021_01_08_423993	204	5	holder	holder	NN
10_1101-2021_01_08_423993	204	6	for	for	IN
10_1101-2021_01_08_423993	204	7	this	this	DT
10_1101-2021_01_08_423993	204	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	204	9	version	version	NN
10_1101-2021_01_08_423993	204	10	posted	post	VBD
10_1101-2021_01_08_423993	204	11	January	January	NNP
10_1101-2021_01_08_423993	204	12	8	8	CD
10_1101-2021_01_08_423993	204	13	,	,	,
10_1101-2021_01_08_423993	204	14	2021	2021	CD
10_1101-2021_01_08_423993	204	15	.	.	.
10_1101-2021_01_08_423993	204	16	;	;	:
10_1101-2021_01_08_423993	204	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	204	18	:	:	:
10_1101-2021_01_08_423993	204	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	204	20	preprint	preprint	NN
10_1101-2021_01_08_423993	204	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	204	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2021_01_08_423993	204	23	The	the	DT
10_1101-2021_01_08_423993	204	24	complementary	complementary	JJ
10_1101-2021_01_08_423993	204	25	strand	strand	NN
10_1101-2021_01_08_423993	204	26	forms	form	VBZ
10_1101-2021_01_08_423993	204	27	interactions	interaction	NNS
10_1101-2021_01_08_423993	204	28	with	with	IN
10_1101-2021_01_08_423993	204	29	the	the	DT
10_1101-2021_01_08_423993	204	30	protein	protein	NN
10_1101-2021_01_08_423993	204	31	via	via	IN
10_1101-2021_01_08_423993	204	32	backbone	backbone	NN
10_1101-2021_01_08_423993	204	33	contacts	contact	NNS
10_1101-2021_01_08_423993	204	34	that	that	WDT
10_1101-2021_01_08_423993	204	35	span	span	VBP
10_1101-2021_01_08_423993	204	36	a	a	DT
10_1101-2021_01_08_423993	204	37	4-nucleotide	4-nucleotide	CD
10_1101-2021_01_08_423993	204	38	stretch	stretch	NN
10_1101-2021_01_08_423993	204	39	between	between	IN
10_1101-2021_01_08_423993	204	40	5-	5-	NNP
10_1101-2021_01_08_423993	204	41	and	and	CC
10_1101-2021_01_08_423993	204	42	8-bases	8-bases	CD
10_1101-2021_01_08_423993	204	43	from	from	IN
10_1101-2021_01_08_423993	204	44	the	the	DT
10_1101-2021_01_08_423993	204	45	3-terminus	3-terminus	NN
10_1101-2021_01_08_423993	204	46	that	that	WDT
10_1101-2021_01_08_423993	204	47	contact	contact	NN
10_1101-2021_01_08_423993	204	48	positively	positively	RB
10_1101-2021_01_08_423993	204	49	charged	charge	VBD
10_1101-2021_01_08_423993	204	50	sidechains	sidechain	NNS
10_1101-2021_01_08_423993	204	51	in	in	IN
10_1101-2021_01_08_423993	204	52	the	the	DT
10_1101-2021_01_08_423993	204	53	MBL	MBL	NNP
10_1101-2021_01_08_423993	204	54	domain	domain	NN
10_1101-2021_01_08_423993	204	55	(	(	-LRB-
10_1101-2021_01_08_423993	204	56	Lys36	Lys36	NNP
10_1101-2021_01_08_423993	204	57	,	,	,
10_1101-2021_01_08_423993	204	58	Lys40	Lys40	NNP
10_1101-2021_01_08_423993	204	59	,	,	,
10_1101-2021_01_08_423993	204	60	Arg43	Arg43	NNP
10_1101-2021_01_08_423993	204	61	,	,	,
10_1101-2021_01_08_423993	204	62	and	and	CC
10_1101-2021_01_08_423993	204	63	Lys74	Lys74	NNP
10_1101-2021_01_08_423993	204	64	)	)	-RRB-
10_1101-2021_01_08_423993	204	65	(	(	-LRB-
10_1101-2021_01_08_423993	204	66	Figure	figure	NN
10_1101-2021_01_08_423993	204	67	6A	6a	NN
10_1101-2021_01_08_423993	204	68	)	)	-RRB-
10_1101-2021_01_08_423993	204	69	.	.	.
10_1101-2021_01_08_423993	205	1	The	the	DT
10_1101-2021_01_08_423993	205	2	3-end	3-end	CD
10_1101-2021_01_08_423993	205	3	of	of	IN
10_1101-2021_01_08_423993	205	4	this	this	DT
10_1101-2021_01_08_423993	205	5	strand	strand	NN
10_1101-2021_01_08_423993	205	6	apparently	apparently	RB
10_1101-2021_01_08_423993	205	7	terminates	terminate	VBZ
10_1101-2021_01_08_423993	205	8	directly	directly	RB
10_1101-2021_01_08_423993	205	9	above	above	IN
10_1101-2021_01_08_423993	205	10	a	a	DT
10_1101-2021_01_08_423993	205	11	cluster	cluster	NN
10_1101-2021_01_08_423993	205	12	of	of	IN
10_1101-2021_01_08_423993	205	13	polar	polar	JJ
10_1101-2021_01_08_423993	205	14	or	or	CC
10_1101-2021_01_08_423993	205	15	positively	positively	RB
10_1101-2021_01_08_423993	205	16	charged	charge	VBN
10_1101-2021_01_08_423993	205	17	residues	residue	NNS
10_1101-2021_01_08_423993	205	18	in	in	IN
10_1101-2021_01_08_423993	205	19	the	the	DT
10_1101-2021_01_08_423993	205	20	β	β	NNP
10_1101-2021_01_08_423993	205	21	-	-	HYPH
10_1101-2021_01_08_423993	205	22	CASP	CASP	NNP
10_1101-2021_01_08_423993	205	23	domain	domain	NN
10_1101-2021_01_08_423993	205	24	(	(	-LRB-
10_1101-2021_01_08_423993	205	25	Lys207	Lys207	NNS
10_1101-2021_01_08_423993	205	26	,	,	,
10_1101-2021_01_08_423993	205	27	Lys288	lys288	CD
10_1101-2021_01_08_423993	205	28	,	,	,
10_1101-2021_01_08_423993	205	29	Asn205	asn205	CD
10_1101-2021_01_08_423993	205	30	)	)	-RRB-
10_1101-2021_01_08_423993	205	31	(	(	-LRB-
10_1101-2021_01_08_423993	205	32	Figure	figure	VB
10_1101-2021_01_08_423993	205	33	6B	6b	NN
10_1101-2021_01_08_423993	205	34	)	)	-RRB-
10_1101-2021_01_08_423993	205	35	.	.	.
10_1101-2021_01_08_423993	206	1	Whilst	whilst	IN
10_1101-2021_01_08_423993	206	2	the	the	DT
10_1101-2021_01_08_423993	206	3	experimental	experimental	NN
10_1101-2021_01_08_423993	206	4	(	(	-LRB-
10_1101-2021_01_08_423993	206	5	as	as	IN
10_1101-2021_01_08_423993	206	6	used	use	VBN
10_1101-2021_01_08_423993	206	7	in	in	IN
10_1101-2021_01_08_423993	206	8	co	co	NN
10_1101-2021_01_08_423993	206	9	-	-	NN
10_1101-2021_01_08_423993	206	10	crystallisation	crystallisation	JJ
10_1101-2021_01_08_423993	206	11	)	)	-RRB-
10_1101-2021_01_08_423993	206	12	DNA	dna	NN
10_1101-2021_01_08_423993	206	13	substrate	substrate	NN
10_1101-2021_01_08_423993	206	14	and	and	CC
10_1101-2021_01_08_423993	206	15	our	-PRON-	PRP$
10_1101-2021_01_08_423993	206	16	model	model	NN
10_1101-2021_01_08_423993	206	17	both	both	DT
10_1101-2021_01_08_423993	206	18	contain	contain	VBP
10_1101-2021_01_08_423993	206	19	a	a	DT
10_1101-2021_01_08_423993	206	20	3'-hydroxyl	3'-hydroxyl	NNP
10_1101-2021_01_08_423993	206	21	group	group	NN
10_1101-2021_01_08_423993	206	22	,	,	,
10_1101-2021_01_08_423993	206	23	the	the	DT
10_1101-2021_01_08_423993	206	24	model	model	NN
10_1101-2021_01_08_423993	206	25	implies	imply	VBZ
10_1101-2021_01_08_423993	206	26	that	that	IN
10_1101-2021_01_08_423993	206	27	addition	addition	NN
10_1101-2021_01_08_423993	206	28	of	of	IN
10_1101-2021_01_08_423993	206	29	a	a	DT
10_1101-2021_01_08_423993	206	30	3'-phosphate	3'-phosphate	NNP
10_1101-2021_01_08_423993	206	31	could	could	MD
10_1101-2021_01_08_423993	206	32	be	be	VB
10_1101-2021_01_08_423993	206	33	accommodated	accommodate	VBN
10_1101-2021_01_08_423993	206	34	and	and	CC
10_1101-2021_01_08_423993	206	35	may	may	MD
10_1101-2021_01_08_423993	206	36	be	be	VB
10_1101-2021_01_08_423993	206	37	expected	expect	VBN
10_1101-2021_01_08_423993	206	38	to	to	TO
10_1101-2021_01_08_423993	206	39	make	make	VB
10_1101-2021_01_08_423993	206	40	favourable	favourable	JJ
10_1101-2021_01_08_423993	206	41	interactions	interaction	NNS
10_1101-2021_01_08_423993	206	42	with	with	IN
10_1101-2021_01_08_423993	206	43	the	the	DT
10_1101-2021_01_08_423993	206	44	basic	basic	JJ
10_1101-2021_01_08_423993	206	45	cluster	cluster	NN
10_1101-2021_01_08_423993	206	46	of	of	IN
10_1101-2021_01_08_423993	206	47	residues	residue	NNS
10_1101-2021_01_08_423993	206	48	.	.	.
10_1101-2021_01_08_423993	207	1	Thus	thus	RB
10_1101-2021_01_08_423993	207	2	,	,	,
10_1101-2021_01_08_423993	207	3	our	-PRON-	PRP$
10_1101-2021_01_08_423993	207	4	model	model	NN
10_1101-2021_01_08_423993	207	5	illustrates	illustrate	VBZ
10_1101-2021_01_08_423993	207	6	a	a	DT
10_1101-2021_01_08_423993	207	7	preferred	preferred	JJ
10_1101-2021_01_08_423993	207	8	binding	binding	NN
10_1101-2021_01_08_423993	207	9	mode	mode	NN
10_1101-2021_01_08_423993	207	10	for	for	IN
10_1101-2021_01_08_423993	207	11	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	207	12	for	for	IN
10_1101-2021_01_08_423993	207	13	DNA	dna	NN
10_1101-2021_01_08_423993	207	14	with	with	IN
10_1101-2021_01_08_423993	207	15	a	a	DT
10_1101-2021_01_08_423993	207	16	5'-overhang	5'-overhang	NNP
10_1101-2021_01_08_423993	207	17	binding	bind	VBG
10_1101-2021_01_08_423993	207	18	at	at	IN
10_1101-2021_01_08_423993	207	19	the	the	DT
10_1101-2021_01_08_423993	207	20	junction	junction	NN
10_1101-2021_01_08_423993	207	21	between	between	IN
10_1101-2021_01_08_423993	207	22	double-	double-	NNS
10_1101-2021_01_08_423993	207	23	and	and	CC
10_1101-2021_01_08_423993	207	24	single	single	JJ
10_1101-2021_01_08_423993	207	25	-	-	HYPH
10_1101-2021_01_08_423993	207	26	stranded	strand	VBN
10_1101-2021_01_08_423993	207	27	regions	region	NNS
10_1101-2021_01_08_423993	207	28	,	,	,
10_1101-2021_01_08_423993	207	29	and	and	CC
10_1101-2021_01_08_423993	207	30	the	the	DT
10_1101-2021_01_08_423993	207	31	expected	expect	VBN
10_1101-2021_01_08_423993	207	32	product	product	NN
10_1101-2021_01_08_423993	207	33	of	of	IN
10_1101-2021_01_08_423993	207	34	this	this	DT
10_1101-2021_01_08_423993	207	35	reaction	reaction	NN
10_1101-2021_01_08_423993	207	36	would	would	MD
10_1101-2021_01_08_423993	207	37	be	be	VB
10_1101-2021_01_08_423993	207	38	a	a	DT
10_1101-2021_01_08_423993	207	39	blunt	blunt	RB
10_1101-2021_01_08_423993	207	40	ended	end	VBN
10_1101-2021_01_08_423993	207	41	DNA	dna	NN
10_1101-2021_01_08_423993	207	42	with	with	IN
10_1101-2021_01_08_423993	207	43	a	a	DT
10_1101-2021_01_08_423993	207	44	5'-phosphate	5'-phosphate	NNP
10_1101-2021_01_08_423993	207	45	.	.	.
10_1101-2021_01_08_423993	208	1	In	in	IN
10_1101-2021_01_08_423993	208	2	the	the	DT
10_1101-2021_01_08_423993	208	3	case	case	NN
10_1101-2021_01_08_423993	208	4	of	of	IN
10_1101-2021_01_08_423993	208	5	hairpin	hairpin	NNP
10_1101-2021_01_08_423993	208	6	DNA	DNA	NNP
10_1101-2021_01_08_423993	208	7	substrates	substrate	VBZ
10_1101-2021_01_08_423993	208	8	our	-PRON-	PRP$
10_1101-2021_01_08_423993	208	9	model	model	NN
10_1101-2021_01_08_423993	208	10	indicates	indicate	VBZ
10_1101-2021_01_08_423993	208	11	the	the	DT
10_1101-2021_01_08_423993	208	12	possibility	possibility	NN
10_1101-2021_01_08_423993	208	13	for	for	IN
10_1101-2021_01_08_423993	208	14	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	208	15	to	to	TO
10_1101-2021_01_08_423993	208	16	accommodate	accommodate	VB
10_1101-2021_01_08_423993	208	17	a	a	DT
10_1101-2021_01_08_423993	208	18	loop	loop	NN
10_1101-2021_01_08_423993	208	19	connecting	connect	VBG
10_1101-2021_01_08_423993	208	20	the	the	DT
10_1101-2021_01_08_423993	208	21	two	two	CD
10_1101-2021_01_08_423993	208	22	strands	strand	NNS
10_1101-2021_01_08_423993	208	23	possibly	possibly	RB
10_1101-2021_01_08_423993	208	24	of	of	IN
10_1101-2021_01_08_423993	208	25	around	around	RB
10_1101-2021_01_08_423993	208	26	4-nucleotides	4-nucleotides	CD
10_1101-2021_01_08_423993	208	27	or	or	CC
10_1101-2021_01_08_423993	208	28	more	more	JJR
10_1101-2021_01_08_423993	208	29	,	,	,
10_1101-2021_01_08_423993	208	30	with	with	IN
10_1101-2021_01_08_423993	208	31	the	the	DT
10_1101-2021_01_08_423993	208	32	cleavage	cleavage	NN
10_1101-2021_01_08_423993	208	33	product	product	NN
10_1101-2021_01_08_423993	208	34	being	be	VBG
10_1101-2021_01_08_423993	208	35	DNA	dna	NN
10_1101-2021_01_08_423993	208	36	with	with	IN
10_1101-2021_01_08_423993	208	37	a	a	DT
10_1101-2021_01_08_423993	208	38	3'-overhang	3'-overhang	NNP
10_1101-2021_01_08_423993	208	39	cleaved	cleave	VBD
10_1101-2021_01_08_423993	208	40	from	from	IN
10_1101-2021_01_08_423993	208	41	the	the	DT
10_1101-2021_01_08_423993	208	42	last	last	JJ
10_1101-2021_01_08_423993	208	43	paired	pair	VBN
10_1101-2021_01_08_423993	208	44	base	base	NN
10_1101-2021_01_08_423993	208	45	of	of	IN
10_1101-2021_01_08_423993	208	46	the	the	DT
10_1101-2021_01_08_423993	208	47	duplex	duplex	NN
10_1101-2021_01_08_423993	208	48	.	.	.
10_1101-2021_01_08_423993	209	1	Comparison	comparison	NN
10_1101-2021_01_08_423993	209	2	of	of	IN
10_1101-2021_01_08_423993	209	3	the	the	DT
10_1101-2021_01_08_423993	209	4	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	209	5	DNA	DNA	NNP
10_1101-2021_01_08_423993	209	6	binding	bind	VBG
10_1101-2021_01_08_423993	209	7	mode	mode	NN
10_1101-2021_01_08_423993	209	8	with	with	IN
10_1101-2021_01_08_423993	209	9	that	that	DT
10_1101-2021_01_08_423993	209	10	of	of	IN
10_1101-2021_01_08_423993	209	11	other	other	JJ
10_1101-2021_01_08_423993	209	12	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	209	13	We	-PRON-	PRP
10_1101-2021_01_08_423993	209	14	have	have	VBP
10_1101-2021_01_08_423993	209	15	recently	recently	RB
10_1101-2021_01_08_423993	209	16	determined	determine	VBN
10_1101-2021_01_08_423993	209	17	the	the	DT
10_1101-2021_01_08_423993	209	18	structure	structure	NN
10_1101-2021_01_08_423993	209	19	of	of	IN
10_1101-2021_01_08_423993	209	20	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	209	21	/	/	SYM
10_1101-2021_01_08_423993	209	22	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	209	23	in	in	IN
10_1101-2021_01_08_423993	209	24	complex	complex	NN
10_1101-2021_01_08_423993	209	25	with	with	IN
10_1101-2021_01_08_423993	209	26	two	two	CD
10_1101-2021_01_08_423993	209	27	deoxyadenosine	deoxyadenosine	NN
10_1101-2021_01_08_423993	209	28	monophosphate	monophosphate	NN
10_1101-2021_01_08_423993	209	29	nucleotides	nucleotide	NNS
10_1101-2021_01_08_423993	209	30	and	and	CC
10_1101-2021_01_08_423993	209	31	through	through	IN
10_1101-2021_01_08_423993	209	32	a	a	DT
10_1101-2021_01_08_423993	209	33	similar	similar	JJ
10_1101-2021_01_08_423993	209	34	process	process	NN
10_1101-2021_01_08_423993	209	35	of	of	IN
10_1101-2021_01_08_423993	209	36	extrapolation	extrapolation	NN
10_1101-2021_01_08_423993	209	37	to	to	IN
10_1101-2021_01_08_423993	209	38	that	that	DT
10_1101-2021_01_08_423993	209	39	outlined	outline	VBN
10_1101-2021_01_08_423993	209	40	above	above	IN
10_1101-2021_01_08_423993	209	41	we	-PRON-	PRP
10_1101-2021_01_08_423993	209	42	have	have	VBP
10_1101-2021_01_08_423993	209	43	independently	independently	RB
10_1101-2021_01_08_423993	209	44	built	build	VBN
10_1101-2021_01_08_423993	209	45	a	a	DT
10_1101-2021_01_08_423993	209	46	model	model	NN
10_1101-2021_01_08_423993	209	47	for	for	IN
10_1101-2021_01_08_423993	209	48	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	209	49	binding	bind	VBG
10_1101-2021_01_08_423993	209	50	to	to	IN
10_1101-2021_01_08_423993	209	51	DNA	DNA	NNP
10_1101-2021_01_08_423993	209	52	containing	contain	VBG
10_1101-2021_01_08_423993	209	53	a	a	DT
10_1101-2021_01_08_423993	209	54	3'-overhang	3'-overhang	NNP
10_1101-2021_01_08_423993	209	55	(	(	-LRB-
10_1101-2021_01_08_423993	209	56	one	one	CD
10_1101-2021_01_08_423993	209	57	of	of	IN
10_1101-2021_01_08_423993	209	58	its	-PRON-	PRP$
10_1101-2021_01_08_423993	209	59	preferred	preferred	JJ
10_1101-2021_01_08_423993	209	60	substrates	substrate	NNS
10_1101-2021_01_08_423993	209	61	)	)	-RRB-
10_1101-2021_01_08_423993	209	62	(	(	-LRB-
10_1101-2021_01_08_423993	209	63	Baddock	baddock	IN
10_1101-2021_01_08_423993	209	64	et.al	et.al	NNS
10_1101-2021_01_08_423993	209	65	.	.	.
10_1101-2021_01_08_423993	210	1	accompanying	accompany	VBG
10_1101-2021_01_08_423993	210	2	paper	paper	NN
10_1101-2021_01_08_423993	210	3	)	)	-RRB-
10_1101-2021_01_08_423993	210	4	.	.	.
10_1101-2021_01_08_423993	211	1	The	the	DT
10_1101-2021_01_08_423993	211	2	overall	overall	JJ
10_1101-2021_01_08_423993	211	3	mode	mode	NN
10_1101-2021_01_08_423993	211	4	of	of	IN
10_1101-2021_01_08_423993	211	5	DNA	dna	NN
10_1101-2021_01_08_423993	211	6	binding	binding	NN
10_1101-2021_01_08_423993	211	7	is	be	VBZ
10_1101-2021_01_08_423993	211	8	similar	similar	JJ
10_1101-2021_01_08_423993	211	9	in	in	IN
10_1101-2021_01_08_423993	211	10	the	the	DT
10_1101-2021_01_08_423993	211	11	two	two	CD
10_1101-2021_01_08_423993	211	12	models	model	NNS
10_1101-2021_01_08_423993	211	13	(	(	-LRB-
10_1101-2021_01_08_423993	211	14	Figure	Figure	NNP
10_1101-2021_01_08_423993	211	15	5	5	CD
10_1101-2021_01_08_423993	211	16	)	)	-RRB-
10_1101-2021_01_08_423993	211	17	,	,	,
10_1101-2021_01_08_423993	211	18	with	with	IN
10_1101-2021_01_08_423993	211	19	the	the	DT
10_1101-2021_01_08_423993	211	20	two	two	CD
10_1101-2021_01_08_423993	211	21	DNA	DNA	NNP
10_1101-2021_01_08_423993	211	22	duplexes	duplex	NNS
10_1101-2021_01_08_423993	211	23	being	be	VBG
10_1101-2021_01_08_423993	211	24	roughly	roughly	RB
10_1101-2021_01_08_423993	211	25	parallel	parallel	JJ
10_1101-2021_01_08_423993	211	26	and	and	CC
10_1101-2021_01_08_423993	211	27	forming	form	VBG
10_1101-2021_01_08_423993	211	28	contacts	contact	NNS
10_1101-2021_01_08_423993	211	29	to	to	IN
10_1101-2021_01_08_423993	211	30	similar	similar	JJ
10_1101-2021_01_08_423993	211	31	regions	region	NNS
10_1101-2021_01_08_423993	211	32	on	on	IN
10_1101-2021_01_08_423993	211	33	the	the	DT
10_1101-2021_01_08_423993	211	34	MBL	MBL	NNP
10_1101-2021_01_08_423993	211	35	domain	domain	NN
10_1101-2021_01_08_423993	211	36	.	.	.
10_1101-2021_01_08_423993	212	1	The	the	DT
10_1101-2021_01_08_423993	212	2	most	most	RBS
10_1101-2021_01_08_423993	212	3	important	important	JJ
10_1101-2021_01_08_423993	212	4	differences	difference	NNS
10_1101-2021_01_08_423993	212	5	lie	lie	VBP
10_1101-2021_01_08_423993	212	6	in	in	IN
10_1101-2021_01_08_423993	212	7	the	the	DT
10_1101-2021_01_08_423993	212	8	nature	nature	NN
10_1101-2021_01_08_423993	212	9	of	of	IN
10_1101-2021_01_08_423993	212	10	the	the	DT
10_1101-2021_01_08_423993	212	11	contacts	contact	NNS
10_1101-2021_01_08_423993	212	12	formed	form	VBN
10_1101-2021_01_08_423993	212	13	to	to	IN
10_1101-2021_01_08_423993	212	14	the	the	DT
10_1101-2021_01_08_423993	212	15	active	active	JJ
10_1101-2021_01_08_423993	212	16	site	site	NN
10_1101-2021_01_08_423993	212	17	and	and	CC
10_1101-2021_01_08_423993	212	18	the	the	DT
10_1101-2021_01_08_423993	212	19	paths	path	NNS
10_1101-2021_01_08_423993	212	20	of	of	IN
10_1101-2021_01_08_423993	212	21	the	the	DT
10_1101-2021_01_08_423993	212	22	various	various	JJ
10_1101-2021_01_08_423993	212	23	overhangs	overhang	NNS
10_1101-2021_01_08_423993	212	24	.	.	.
10_1101-2021_01_08_423993	213	1	In	in	IN
10_1101-2021_01_08_423993	213	2	the	the	DT
10_1101-2021_01_08_423993	213	3	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	213	4	model	model	NN
10_1101-2021_01_08_423993	213	5	extensive	extensive	JJ
10_1101-2021_01_08_423993	213	6	contacts	contact	NNS
10_1101-2021_01_08_423993	213	7	are	be	VBP
10_1101-2021_01_08_423993	213	8	made	make	VBN
10_1101-2021_01_08_423993	213	9	to	to	IN
10_1101-2021_01_08_423993	213	10	the	the	DT
10_1101-2021_01_08_423993	213	11	5-phosphate	5-phosphate	CD
10_1101-2021_01_08_423993	213	12	in	in	IN
10_1101-2021_01_08_423993	213	13	a	a	DT
10_1101-2021_01_08_423993	213	14	well	well	RB
10_1101-2021_01_08_423993	213	15	-	-	HYPH
10_1101-2021_01_08_423993	213	16	defined	define	VBN
10_1101-2021_01_08_423993	213	17	phosphate	phosphate	NN
10_1101-2021_01_08_423993	213	18	binding	binding	NN
10_1101-2021_01_08_423993	213	19	pocket	pocket	NN
10_1101-2021_01_08_423993	213	20	.	.	.
10_1101-2021_01_08_423993	214	1	Both	both	DT
10_1101-2021_01_08_423993	214	2	human	human	JJ
10_1101-2021_01_08_423993	214	3	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	214	4	and	and	CC
10_1101-2021_01_08_423993	214	5	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	214	6	are	be	VBP
10_1101-2021_01_08_423993	214	7	exclusively	exclusively	RB
10_1101-2021_01_08_423993	214	8	5-phosphate	5-phosphate	CD
10_1101-2021_01_08_423993	214	9	exonucleases	exonuclease	NNS
10_1101-2021_01_08_423993	214	10	,	,	,
10_1101-2021_01_08_423993	214	11	with	with	IN
10_1101-2021_01_08_423993	214	12	most	most	JJS
10_1101-2021_01_08_423993	214	13	of	of	IN
10_1101-2021_01_08_423993	214	14	these	these	DT
10_1101-2021_01_08_423993	214	15	phosphate	phosphate	NN
10_1101-2021_01_08_423993	214	16	binding	binding	NN
10_1101-2021_01_08_423993	214	17	residues	residue	NNS
10_1101-2021_01_08_423993	214	18	being	be	VBG
10_1101-2021_01_08_423993	214	19	highly	highly	RB
10_1101-2021_01_08_423993	214	20	conserved	conserve	VBN
10_1101-2021_01_08_423993	214	21	(	(	-LRB-
10_1101-2021_01_08_423993	214	22	sequence	sequence	NN
10_1101-2021_01_08_423993	214	23	alignment	alignment	NN
10_1101-2021_01_08_423993	214	24	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	214	25	.	.	.
10_1101-2021_01_08_423993	215	1	Figure	figure	NN
10_1101-2021_01_08_423993	215	2	1	1	CD
10_1101-2021_01_08_423993	215	3	in	in	IN
10_1101-2021_01_08_423993	215	4	yellow	yellow	NN
10_1101-2021_01_08_423993	215	5	)	)	-RRB-
10_1101-2021_01_08_423993	215	6	(	(	-LRB-
10_1101-2021_01_08_423993	215	7	Baddock	Baddock	NNP
10_1101-2021_01_08_423993	215	8	et	et	NNP
10_1101-2021_01_08_423993	215	9	.	.	.
10_1101-2021_01_08_423993	216	1	al	al	NNP
10_1101-2021_01_08_423993	216	2	accompanying	accompanying	NNP
10_1101-2021_01_08_423993	216	3	paper	paper	NN
10_1101-2021_01_08_423993	216	4	)	)	-RRB-
10_1101-2021_01_08_423993	216	5	.	.	.
10_1101-2021_01_08_423993	217	1	Interestingly	interestingly	RB
10_1101-2021_01_08_423993	217	2	,	,	,
10_1101-2021_01_08_423993	217	3	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	217	4	lacks	lack	VBZ
10_1101-2021_01_08_423993	217	5	these	these	DT
10_1101-2021_01_08_423993	217	6	key	key	JJ
10_1101-2021_01_08_423993	217	7	phosphate	phosphate	NN
10_1101-2021_01_08_423993	217	8	binding	binding	NN
10_1101-2021_01_08_423993	217	9	residues	residue	NNS
10_1101-2021_01_08_423993	217	10	and	and	CC
10_1101-2021_01_08_423993	217	11	the	the	DT
10_1101-2021_01_08_423993	217	12	5-phosphate	5-phosphate	CD
10_1101-2021_01_08_423993	217	13	binding	bind	VBG
10_1101-2021_01_08_423993	217	14	pocket	pocket	NN
10_1101-2021_01_08_423993	217	15	of	of	IN
10_1101-2021_01_08_423993	217	16	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	217	17	and	and	CC
10_1101-2021_01_08_423993	217	18	SNM1B.	snm1b.	NN
10_1101-2021_01_08_423993	218	1	Instead	instead	RB
10_1101-2021_01_08_423993	218	2	,	,	,
10_1101-2021_01_08_423993	218	3	this	this	DT
10_1101-2021_01_08_423993	218	4	pocket	pocket	NN
10_1101-2021_01_08_423993	218	5	in	in	IN
10_1101-2021_01_08_423993	218	6	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	218	7	is	be	VBZ
10_1101-2021_01_08_423993	218	8	partially	partially	RB
10_1101-2021_01_08_423993	218	9	filled	fill	VBN
10_1101-2021_01_08_423993	218	10	by	by	IN
10_1101-2021_01_08_423993	218	11	the	the	DT
10_1101-2021_01_08_423993	218	12	side	side	NN
10_1101-2021_01_08_423993	218	13	chain	chain	NN
10_1101-2021_01_08_423993	218	14	of	of	IN
10_1101-2021_01_08_423993	218	15	Phe318	phe318	CD
10_1101-2021_01_08_423993	218	16	.	.	.
10_1101-2021_01_08_423993	219	1	These	these	DT
10_1101-2021_01_08_423993	219	2	contacts	contact	NNS
10_1101-2021_01_08_423993	219	3	appear	appear	VBP
10_1101-2021_01_08_423993	219	4	to	to	TO
10_1101-2021_01_08_423993	219	5	define	define	VB
10_1101-2021_01_08_423993	219	6	a	a	DT
10_1101-2021_01_08_423993	219	7	high	high	JJ
10_1101-2021_01_08_423993	219	8	-	-	HYPH
10_1101-2021_01_08_423993	219	9	affinity	affinity	NN
10_1101-2021_01_08_423993	219	10	binding	bind	VBG
10_1101-2021_01_08_423993	219	11	pocket	pocket	NN
10_1101-2021_01_08_423993	219	12	exclusively	exclusively	RB
10_1101-2021_01_08_423993	219	13	for	for	IN
10_1101-2021_01_08_423993	219	14	the	the	DT
10_1101-2021_01_08_423993	219	15	5-phosphate	5-phosphate	CD
10_1101-2021_01_08_423993	219	16	of	of	IN
10_1101-2021_01_08_423993	219	17	the	the	DT
10_1101-2021_01_08_423993	219	18	DNA	DNA	NNP
10_1101-2021_01_08_423993	219	19	terminus	terminus	NN
10_1101-2021_01_08_423993	219	20	,	,	,
10_1101-2021_01_08_423993	219	21	thus	thus	RB
10_1101-2021_01_08_423993	219	22	explaining	explain	VBG
10_1101-2021_01_08_423993	219	23	the	the	DT
10_1101-2021_01_08_423993	219	24	major	major	JJ
10_1101-2021_01_08_423993	219	25	differences	difference	NNS
10_1101-2021_01_08_423993	219	26	in	in	IN
10_1101-2021_01_08_423993	219	27	nuclease	nuclease	NN
10_1101-2021_01_08_423993	219	28	activities	activity	NNS
10_1101-2021_01_08_423993	219	29	within	within	IN
10_1101-2021_01_08_423993	219	30	the	the	DT
10_1101-2021_01_08_423993	219	31	family	family	NN
10_1101-2021_01_08_423993	219	32	,	,	,
10_1101-2021_01_08_423993	219	33	i.e.	i.e.	FW
10_1101-2021_01_08_423993	219	34	,	,	,
10_1101-2021_01_08_423993	219	35	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	219	36	and	and	CC
10_1101-2021_01_08_423993	219	37	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	219	38	being	be	VBG
10_1101-2021_01_08_423993	219	39	exonucleases	exonuclease	NNS
10_1101-2021_01_08_423993	219	40	and	and	CC
10_1101-2021_01_08_423993	219	41	Artemis	artemi	NNS
10_1101-2021_01_08_423993	219	42	being	be	VBG
10_1101-2021_01_08_423993	219	43	an	an	DT
10_1101-2021_01_08_423993	219	44	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	219	45	.	.	.
10_1101-2021_01_08_423993	220	1	Further	further	JJ
10_1101-2021_01_08_423993	220	2	differences	difference	NNS
10_1101-2021_01_08_423993	220	3	between	between	IN
10_1101-2021_01_08_423993	220	4	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	220	5	and	and	CC
10_1101-2021_01_08_423993	220	6	SNM1B	SNM1B	NNS
10_1101-2021_01_08_423993	220	7	/	/	SYM
10_1101-2021_01_08_423993	220	8	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	220	9	are	be	VBP
10_1101-2021_01_08_423993	220	10	found	find	VBN
10_1101-2021_01_08_423993	220	11	in	in	IN
10_1101-2021_01_08_423993	220	12	the	the	DT
10_1101-2021_01_08_423993	220	13	loop	loop	NN
10_1101-2021_01_08_423993	220	14	connecting	connect	VBG
10_1101-2021_01_08_423993	220	15	β	β	NN
10_1101-2021_01_08_423993	220	16	-	-	HYPH
10_1101-2021_01_08_423993	220	17	strands	strand	VBZ
10_1101-2021_01_08_423993	220	18	G	g	NN
10_1101-2021_01_08_423993	220	19	and	and	CC
10_1101-2021_01_08_423993	220	20	H	H	NNP
10_1101-2021_01_08_423993	220	21	(	(	-LRB-
10_1101-2021_01_08_423993	220	22	using	use	VBG
10_1101-2021_01_08_423993	220	23	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	220	24	numbering	numbering	NN
10_1101-2021_01_08_423993	220	25	)	)	-RRB-
10_1101-2021_01_08_423993	220	26	,	,	,
10_1101-2021_01_08_423993	220	27	which	which	WDT
10_1101-2021_01_08_423993	220	28	in	in	IN
10_1101-2021_01_08_423993	220	29	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	220	30	is	be	VBZ
10_1101-2021_01_08_423993	220	31	significantly	significantly	RB
10_1101-2021_01_08_423993	220	32	longer	long	JJR
10_1101-2021_01_08_423993	220	33	and	and	CC
10_1101-2021_01_08_423993	220	34	occupies	occupy	VBZ
10_1101-2021_01_08_423993	220	35	a	a	DT
10_1101-2021_01_08_423993	220	36	different	different	JJ
10_1101-2021_01_08_423993	220	37	position	position	NN
10_1101-2021_01_08_423993	220	38	contacting	contact	VBG
10_1101-2021_01_08_423993	220	39	residues	residue	NNS
10_1101-2021_01_08_423993	220	40	in	in	IN
10_1101-2021_01_08_423993	220	41	the	the	DT
10_1101-2021_01_08_423993	220	42	MBL	MBL	NNP
10_1101-2021_01_08_423993	220	43	domain	domain	NN
10_1101-2021_01_08_423993	220	44	(	(	-LRB-
10_1101-2021_01_08_423993	220	45	Figure	Figure	NNP
10_1101-2021_01_08_423993	220	46	6B	6b	NN
10_1101-2021_01_08_423993	220	47	)	)	-RRB-
10_1101-2021_01_08_423993	220	48	,	,	,
10_1101-2021_01_08_423993	220	49	compared	compare	VBN
10_1101-2021_01_08_423993	220	50	to	to	IN
10_1101-2021_01_08_423993	220	51	the	the	DT
10_1101-2021_01_08_423993	220	52	loops	loop	NNS
10_1101-2021_01_08_423993	220	53	in	in	IN
10_1101-2021_01_08_423993	220	54	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	220	55	and	and	CC
10_1101-2021_01_08_423993	220	56	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	220	57	that	that	WDT
10_1101-2021_01_08_423993	220	58	form	form	VBP
10_1101-2021_01_08_423993	220	59	part	part	NN
10_1101-2021_01_08_423993	220	60	of	of	IN
10_1101-2021_01_08_423993	220	61	the	the	DT
10_1101-2021_01_08_423993	220	62	phosphate	phosphate	NN
10_1101-2021_01_08_423993	220	63	binding	binding	NN
10_1101-2021_01_08_423993	220	64	pocket	pocket	NN
10_1101-2021_01_08_423993	220	65	and	and	CC
10_1101-2021_01_08_423993	220	66	make	make	VB
10_1101-2021_01_08_423993	220	67	potential	potential	JJ
10_1101-2021_01_08_423993	220	68	contacts	contact	NNS
10_1101-2021_01_08_423993	220	69	with	with	IN
10_1101-2021_01_08_423993	220	70	the	the	DT
10_1101-2021_01_08_423993	220	71	3'-overhang	3'-overhang	NNP
10_1101-2021_01_08_423993	220	72	.	.	.
10_1101-2021_01_08_423993	221	1	This	this	DT
10_1101-2021_01_08_423993	221	2	loop	loop	NN
10_1101-2021_01_08_423993	221	3	displacement	displacement	NN
10_1101-2021_01_08_423993	221	4	in	in	IN
10_1101-2021_01_08_423993	221	5	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	221	6	may	may	MD
10_1101-2021_01_08_423993	221	7	contribute	contribute	VB
10_1101-2021_01_08_423993	221	8	to	to	IN
10_1101-2021_01_08_423993	221	9	its	-PRON-	PRP$
10_1101-2021_01_08_423993	221	10	ability	ability	NN
10_1101-2021_01_08_423993	221	11	in	in	IN
10_1101-2021_01_08_423993	221	12	accommodating	accommodate	VBG
10_1101-2021_01_08_423993	221	13	DNA	dna	NN
10_1101-2021_01_08_423993	221	14	substrates	substrate	NNS
10_1101-2021_01_08_423993	221	15	.CC	.CC	:
10_1101-2021_01_08_423993	221	16	-	-	:
10_1101-2021_01_08_423993	221	17	BY	by	IN
10_1101-2021_01_08_423993	221	18	4.0	4.0	CD
10_1101-2021_01_08_423993	221	19	International	international	JJ
10_1101-2021_01_08_423993	221	20	licensemade	licensemade	NN
10_1101-2021_01_08_423993	221	21	available	available	JJ
10_1101-2021_01_08_423993	221	22	under	under	IN
10_1101-2021_01_08_423993	221	23	a	a	DT
10_1101-2021_01_08_423993	221	24	(	(	-LRB-
10_1101-2021_01_08_423993	221	25	which	which	WDT
10_1101-2021_01_08_423993	221	26	was	be	VBD
10_1101-2021_01_08_423993	221	27	not	not	RB
10_1101-2021_01_08_423993	221	28	certified	certify	VBN
10_1101-2021_01_08_423993	221	29	by	by	IN
10_1101-2021_01_08_423993	221	30	peer	peer	NN
10_1101-2021_01_08_423993	221	31	review	review	NN
10_1101-2021_01_08_423993	221	32	)	)	-RRB-
10_1101-2021_01_08_423993	221	33	is	be	VBZ
10_1101-2021_01_08_423993	221	34	the	the	DT
10_1101-2021_01_08_423993	221	35	author	author	NN
10_1101-2021_01_08_423993	221	36	/	/	SYM
10_1101-2021_01_08_423993	221	37	funder	funder	NN
10_1101-2021_01_08_423993	221	38	,	,	,
10_1101-2021_01_08_423993	221	39	who	who	WP
10_1101-2021_01_08_423993	221	40	has	have	VBZ
10_1101-2021_01_08_423993	221	41	granted	grant	VBN
10_1101-2021_01_08_423993	221	42	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	221	43	a	a	DT
10_1101-2021_01_08_423993	221	44	license	license	NN
10_1101-2021_01_08_423993	221	45	to	to	TO
10_1101-2021_01_08_423993	221	46	display	display	VB
10_1101-2021_01_08_423993	221	47	the	the	DT
10_1101-2021_01_08_423993	221	48	preprint	preprint	NN
10_1101-2021_01_08_423993	221	49	in	in	IN
10_1101-2021_01_08_423993	221	50	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	221	51	.	.	.
10_1101-2021_01_08_423993	222	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	222	2	is	be	VBZ
10_1101-2021_01_08_423993	222	3	The	the	DT
10_1101-2021_01_08_423993	222	4	copyright	copyright	NN
10_1101-2021_01_08_423993	222	5	holder	holder	NN
10_1101-2021_01_08_423993	222	6	for	for	IN
10_1101-2021_01_08_423993	222	7	this	this	DT
10_1101-2021_01_08_423993	222	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	222	9	version	version	NN
10_1101-2021_01_08_423993	222	10	posted	post	VBD
10_1101-2021_01_08_423993	222	11	January	January	NNP
10_1101-2021_01_08_423993	222	12	8	8	CD
10_1101-2021_01_08_423993	222	13	,	,	,
10_1101-2021_01_08_423993	222	14	2021	2021	CD
10_1101-2021_01_08_423993	222	15	.	.	.
10_1101-2021_01_08_423993	222	16	;	;	:
10_1101-2021_01_08_423993	222	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	222	18	:	:	:
10_1101-2021_01_08_423993	222	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	222	20	preprint	preprint	NN
10_1101-2021_01_08_423993	222	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	NN
10_1101-2021_01_08_423993	222	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2021_01_08_423993	222	23	with	with	IN
10_1101-2021_01_08_423993	222	24	either	either	DT
10_1101-2021_01_08_423993	222	25	5-overhangs	5-overhang	NNS
10_1101-2021_01_08_423993	222	26	or	or	CC
10_1101-2021_01_08_423993	222	27	hairpins	hairpin	NNS
10_1101-2021_01_08_423993	222	28	,	,	,
10_1101-2021_01_08_423993	222	29	thus	thus	RB
10_1101-2021_01_08_423993	222	30	facilitating	facilitate	VBG
10_1101-2021_01_08_423993	222	31	its	-PRON-	PRP$
10_1101-2021_01_08_423993	222	32	function	function	NN
10_1101-2021_01_08_423993	222	33	as	as	IN
10_1101-2021_01_08_423993	222	34	a	a	DT
10_1101-2021_01_08_423993	222	35	structure	structure	NN
10_1101-2021_01_08_423993	222	36	specific	specific	JJ
10_1101-2021_01_08_423993	222	37	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	222	38	.	.	.
10_1101-2021_01_08_423993	223	1	Interestingly	interestingly	RB
10_1101-2021_01_08_423993	223	2	,	,	,
10_1101-2021_01_08_423993	223	3	the	the	DT
10_1101-2021_01_08_423993	223	4	surface	surface	NN
10_1101-2021_01_08_423993	223	5	of	of	IN
10_1101-2021_01_08_423993	223	6	the	the	DT
10_1101-2021_01_08_423993	223	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	223	8	interface	interface	NN
10_1101-2021_01_08_423993	223	9	between	between	IN
10_1101-2021_01_08_423993	223	10	the	the	DT
10_1101-2021_01_08_423993	223	11	MBL	MBL	NNP
10_1101-2021_01_08_423993	223	12	and	and	CC
10_1101-2021_01_08_423993	223	13	β	β	NNP
10_1101-2021_01_08_423993	223	14	-	-	HYPH
10_1101-2021_01_08_423993	223	15	CASP	CASP	NNP
10_1101-2021_01_08_423993	223	16	domains	domain	NNS
10_1101-2021_01_08_423993	223	17	contains	contain	VBZ
10_1101-2021_01_08_423993	223	18	a	a	DT
10_1101-2021_01_08_423993	223	19	belt	belt	NN
10_1101-2021_01_08_423993	223	20	of	of	IN
10_1101-2021_01_08_423993	223	21	positively	positively	RB
10_1101-2021_01_08_423993	223	22	charged	charge	VBN
10_1101-2021_01_08_423993	223	23	residues	residue	NNS
10_1101-2021_01_08_423993	223	24	(	(	-LRB-
10_1101-2021_01_08_423993	223	25	Figure	figure	NN
10_1101-2021_01_08_423993	223	26	5A	5a	RB
10_1101-2021_01_08_423993	223	27	)	)	-RRB-
10_1101-2021_01_08_423993	223	28	.	.	.
10_1101-2021_01_08_423993	224	1	These	these	DT
10_1101-2021_01_08_423993	224	2	positive	positive	JJ
10_1101-2021_01_08_423993	224	3	surface	surface	NN
10_1101-2021_01_08_423993	224	4	charges	charge	NNS
10_1101-2021_01_08_423993	224	5	are	be	VBP
10_1101-2021_01_08_423993	224	6	proposed	propose	VBN
10_1101-2021_01_08_423993	224	7	to	to	TO
10_1101-2021_01_08_423993	224	8	facilitate	facilitate	VB
10_1101-2021_01_08_423993	224	9	productive	productive	JJ
10_1101-2021_01_08_423993	224	10	DNA	dna	NN
10_1101-2021_01_08_423993	224	11	binding	bind	VBG
10_1101-2021_01_08_423993	224	12	to	to	IN
10_1101-2021_01_08_423993	224	13	the	the	DT
10_1101-2021_01_08_423993	224	14	active	active	JJ
10_1101-2021_01_08_423993	224	15	site	site	NN
10_1101-2021_01_08_423993	224	16	,	,	,
10_1101-2021_01_08_423993	224	17	consistent	consistent	JJ
10_1101-2021_01_08_423993	224	18	with	with	IN
10_1101-2021_01_08_423993	224	19	our	-PRON-	PRP$
10_1101-2021_01_08_423993	224	20	DNA	dna	NN
10_1101-2021_01_08_423993	224	21	binding	bind	VBG
10_1101-2021_01_08_423993	224	22	model	model	NN
10_1101-2021_01_08_423993	224	23	.	.	.
10_1101-2021_01_08_423993	225	1	One	one	CD
10_1101-2021_01_08_423993	225	2	of	of	IN
10_1101-2021_01_08_423993	225	3	the	the	DT
10_1101-2021_01_08_423993	225	4	striking	strike	VBG
10_1101-2021_01_08_423993	225	5	differences	difference	NNS
10_1101-2021_01_08_423993	225	6	,	,	,
10_1101-2021_01_08_423993	225	7	at	at	IN
10_1101-2021_01_08_423993	225	8	least	least	JJS
10_1101-2021_01_08_423993	225	9	in	in	IN
10_1101-2021_01_08_423993	225	10	the	the	DT
10_1101-2021_01_08_423993	225	11	available	available	JJ
10_1101-2021_01_08_423993	225	12	structures	structure	NNS
10_1101-2021_01_08_423993	225	13	,	,	,
10_1101-2021_01_08_423993	225	14	is	be	VBZ
10_1101-2021_01_08_423993	225	15	that	that	IN
10_1101-2021_01_08_423993	225	16	the	the	DT
10_1101-2021_01_08_423993	225	17	active	active	JJ
10_1101-2021_01_08_423993	225	18	site	site	NN
10_1101-2021_01_08_423993	225	19	of	of	IN
10_1101-2021_01_08_423993	225	20	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	225	21	is	be	VBZ
10_1101-2021_01_08_423993	225	22	more	more	RBR
10_1101-2021_01_08_423993	225	23	open	open	JJ
10_1101-2021_01_08_423993	225	24	compared	compare	VBN
10_1101-2021_01_08_423993	225	25	to	to	IN
10_1101-2021_01_08_423993	225	26	those	those	DT
10_1101-2021_01_08_423993	225	27	of	of	IN
10_1101-2021_01_08_423993	225	28	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	225	29	or	or	CC
10_1101-2021_01_08_423993	225	30	SNM1B.	snm1b.	NN
10_1101-2021_01_08_423993	226	1	This	this	DT
10_1101-2021_01_08_423993	226	2	openness	openness	NN
10_1101-2021_01_08_423993	226	3	may	may	MD
10_1101-2021_01_08_423993	226	4	reflect	reflect	VB
10_1101-2021_01_08_423993	226	5	an	an	DT
10_1101-2021_01_08_423993	226	6	ability	ability	NN
10_1101-2021_01_08_423993	226	7	to	to	TO
10_1101-2021_01_08_423993	226	8	accommodate	accommodate	VB
10_1101-2021_01_08_423993	226	9	different	different	JJ
10_1101-2021_01_08_423993	226	10	substrate	substrate	NN
10_1101-2021_01_08_423993	226	11	conformation	conformation	NN
10_1101-2021_01_08_423993	226	12	including	include	VBG
10_1101-2021_01_08_423993	226	13	hairpins	hairpin	NNS
10_1101-2021_01_08_423993	226	14	,	,	,
10_1101-2021_01_08_423993	226	15	3'-	3'-	CD
10_1101-2021_01_08_423993	226	16	and	and	CC
10_1101-2021_01_08_423993	226	17	5'-overhangs	5'-overhangs	NNPS
10_1101-2021_01_08_423993	226	18	,	,	,
10_1101-2021_01_08_423993	226	19	as	as	RB
10_1101-2021_01_08_423993	226	20	well	well	RB
10_1101-2021_01_08_423993	226	21	as	as	IN
10_1101-2021_01_08_423993	226	22	DNA	DNA	NNP
10_1101-2021_01_08_423993	226	23	flaps	flap	NNS
10_1101-2021_01_08_423993	226	24	and	and	CC
10_1101-2021_01_08_423993	226	25	gaps	gap	NNS
10_1101-2021_01_08_423993	226	26	.	.	.
10_1101-2021_01_08_423993	227	1	Both	both	DT
10_1101-2021_01_08_423993	227	2	human	human	JJ
10_1101-2021_01_08_423993	227	3	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	227	4	and	and	CC
10_1101-2021_01_08_423993	227	5	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	227	6	appear	appear	VBP
10_1101-2021_01_08_423993	227	7	to	to	TO
10_1101-2021_01_08_423993	227	8	have	have	VB
10_1101-2021_01_08_423993	227	9	a	a	DT
10_1101-2021_01_08_423993	227	10	more	more	RBR
10_1101-2021_01_08_423993	227	11	sequestered	sequester	VBN
10_1101-2021_01_08_423993	227	12	active	active	JJ
10_1101-2021_01_08_423993	227	13	site	site	NN
10_1101-2021_01_08_423993	227	14	that	that	WDT
10_1101-2021_01_08_423993	227	15	would	would	MD
10_1101-2021_01_08_423993	227	16	only	only	RB
10_1101-2021_01_08_423993	227	17	fit	fit	VB
10_1101-2021_01_08_423993	227	18	a	a	DT
10_1101-2021_01_08_423993	227	19	single	single	JJ
10_1101-2021_01_08_423993	227	20	strand	strand	NN
10_1101-2021_01_08_423993	227	21	of	of	IN
10_1101-2021_01_08_423993	227	22	DNA	dna	NN
10_1101-2021_01_08_423993	227	23	,	,	,
10_1101-2021_01_08_423993	227	24	which	which	WDT
10_1101-2021_01_08_423993	227	25	is	be	VBZ
10_1101-2021_01_08_423993	227	26	consistent	consistent	JJ
10_1101-2021_01_08_423993	227	27	with	with	IN
10_1101-2021_01_08_423993	227	28	previous	previous	JJ
10_1101-2021_01_08_423993	227	29	findings	finding	NNS
10_1101-2021_01_08_423993	227	30	on	on	IN
10_1101-2021_01_08_423993	227	31	their	-PRON-	PRP$
10_1101-2021_01_08_423993	227	32	preferred	preferred	JJ
10_1101-2021_01_08_423993	227	33	substrate	substrate	NN
10_1101-2021_01_08_423993	227	34	selectivity	selectivity	NN
10_1101-2021_01_08_423993	227	35	[	[	-LRB-
10_1101-2021_01_08_423993	227	36	10	10	CD
10_1101-2021_01_08_423993	227	37	]	]	-RRB-
10_1101-2021_01_08_423993	227	38	.	.	.
10_1101-2021_01_08_423993	228	1	Biochemical	biochemical	JJ
10_1101-2021_01_08_423993	228	2	characterisation	characterisation	NN
10_1101-2021_01_08_423993	228	3	of	of	IN
10_1101-2021_01_08_423993	228	4	truncated	truncate	VBN
10_1101-2021_01_08_423993	228	5	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	228	6	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	228	7	domain	domain	NN
10_1101-2021_01_08_423993	228	8	(	(	-LRB-
10_1101-2021_01_08_423993	228	9	aa	aa	NNP
10_1101-2021_01_08_423993	228	10	1	1	CD
10_1101-2021_01_08_423993	228	11	-	-	SYM
10_1101-2021_01_08_423993	228	12	361	361	CD
10_1101-2021_01_08_423993	228	13	)	)	-RRB-
10_1101-2021_01_08_423993	228	14	To	to	TO
10_1101-2021_01_08_423993	228	15	investigate	investigate	VB
10_1101-2021_01_08_423993	228	16	the	the	DT
10_1101-2021_01_08_423993	228	17	activity	activity	NN
10_1101-2021_01_08_423993	228	18	of	of	IN
10_1101-2021_01_08_423993	228	19	our	-PRON-	PRP$
10_1101-2021_01_08_423993	228	20	different	different	JJ
10_1101-2021_01_08_423993	228	21	versions	version	NNS
10_1101-2021_01_08_423993	228	22	of	of	IN
10_1101-2021_01_08_423993	228	23	recombinant	recombinant	JJ
10_1101-2021_01_08_423993	228	24	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	228	25	,	,	,
10_1101-2021_01_08_423993	228	26	we	-PRON-	PRP
10_1101-2021_01_08_423993	228	27	performed	perform	VBD
10_1101-2021_01_08_423993	228	28	nuclease	nuclease	NNP
10_1101-2021_01_08_423993	228	29	assays	assays	RB
10_1101-2021_01_08_423993	228	30	using	use	VBG
10_1101-2021_01_08_423993	228	31	radiolabelled	radiolabelle	VBN
10_1101-2021_01_08_423993	228	32	DNA	dna	NN
10_1101-2021_01_08_423993	228	33	substrates	substrate	NNS
10_1101-2021_01_08_423993	228	34	.	.	.
10_1101-2021_01_08_423993	229	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	229	2	compared	compare	VBD
10_1101-2021_01_08_423993	229	3	the	the	DT
10_1101-2021_01_08_423993	229	4	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	229	5	domain	domain	NN
10_1101-2021_01_08_423993	229	6	purified	purify	VBN
10_1101-2021_01_08_423993	229	7	using	use	VBG
10_1101-2021_01_08_423993	229	8	IMAC	IMAC	NNP
10_1101-2021_01_08_423993	229	9	(	(	-LRB-
10_1101-2021_01_08_423993	229	10	which	which	WDT
10_1101-2021_01_08_423993	229	11	contained	contain	VBD
10_1101-2021_01_08_423993	229	12	Ni2	Ni2	NNP
10_1101-2021_01_08_423993	229	13	+	+	SYM
10_1101-2021_01_08_423993	229	14	in	in	IN
10_1101-2021_01_08_423993	229	15	the	the	DT
10_1101-2021_01_08_423993	229	16	active	active	JJ
10_1101-2021_01_08_423993	229	17	site	site	NN
10_1101-2021_01_08_423993	229	18	)	)	-RRB-
10_1101-2021_01_08_423993	229	19	with	with	IN
10_1101-2021_01_08_423993	229	20	protein	protein	NN
10_1101-2021_01_08_423993	229	21	purified	purify	VBN
10_1101-2021_01_08_423993	229	22	using	use	VBG
10_1101-2021_01_08_423993	229	23	ion	ion	NN
10_1101-2021_01_08_423993	229	24	exchange	exchange	NN
10_1101-2021_01_08_423993	229	25	(	(	-LRB-
10_1101-2021_01_08_423993	229	26	and	and	CC
10_1101-2021_01_08_423993	229	27	avoiding	avoid	VBG
10_1101-2021_01_08_423993	229	28	IMAC	IMAC	NNP
10_1101-2021_01_08_423993	229	29	)	)	-RRB-
10_1101-2021_01_08_423993	229	30	,	,	,
10_1101-2021_01_08_423993	229	31	which	which	WDT
10_1101-2021_01_08_423993	229	32	contained	contain	VBD
10_1101-2021_01_08_423993	229	33	predominantly	predominantly	RB
10_1101-2021_01_08_423993	229	34	Zn2	Zn2	NNP
10_1101-2021_01_08_423993	229	35	+	+	NFP
10_1101-2021_01_08_423993	229	36	.	.	.
10_1101-2021_01_08_423993	230	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	230	2	also	also	RB
10_1101-2021_01_08_423993	230	3	tested	test	VBD
10_1101-2021_01_08_423993	230	4	the	the	DT
10_1101-2021_01_08_423993	230	5	activity	activity	NN
10_1101-2021_01_08_423993	230	6	of	of	IN
10_1101-2021_01_08_423993	230	7	full	full	JJ
10_1101-2021_01_08_423993	230	8	-	-	HYPH
10_1101-2021_01_08_423993	230	9	length	length	NN
10_1101-2021_01_08_423993	230	10	phosphorylated	phosphorylate	VBN
10_1101-2021_01_08_423993	230	11	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	230	12	.	.	.
10_1101-2021_01_08_423993	231	1	The	the	DT
10_1101-2021_01_08_423993	231	2	results	result	NNS
10_1101-2021_01_08_423993	231	3	show	show	VBP
10_1101-2021_01_08_423993	231	4	that	that	IN
10_1101-2021_01_08_423993	231	5	both	both	DT
10_1101-2021_01_08_423993	231	6	truncated	truncate	VBN
10_1101-2021_01_08_423993	231	7	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	231	8	have	have	VBP
10_1101-2021_01_08_423993	231	9	identical	identical	JJ
10_1101-2021_01_08_423993	231	10	activities	activity	NNS
10_1101-2021_01_08_423993	231	11	,	,	,
10_1101-2021_01_08_423993	231	12	which	which	WDT
10_1101-2021_01_08_423993	231	13	is	be	VBZ
10_1101-2021_01_08_423993	231	14	also	also	RB
10_1101-2021_01_08_423993	231	15	very	very	RB
10_1101-2021_01_08_423993	231	16	similar	similar	JJ
10_1101-2021_01_08_423993	231	17	to	to	IN
10_1101-2021_01_08_423993	231	18	that	that	DT
10_1101-2021_01_08_423993	231	19	of	of	IN
10_1101-2021_01_08_423993	231	20	the	the	DT
10_1101-2021_01_08_423993	231	21	full-	full-	NN
10_1101-2021_01_08_423993	231	22	length	length	NN
10_1101-2021_01_08_423993	231	23	enzyme	enzyme	NNS
10_1101-2021_01_08_423993	231	24	(	(	-LRB-
10_1101-2021_01_08_423993	231	25	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	231	26	.	.	.
10_1101-2021_01_08_423993	232	1	Figure	figure	NN
10_1101-2021_01_08_423993	232	2	6	6	CD
10_1101-2021_01_08_423993	232	3	)	)	-RRB-
10_1101-2021_01_08_423993	232	4	.	.	.
10_1101-2021_01_08_423993	233	1	One	one	CD
10_1101-2021_01_08_423993	233	2	notable	notable	JJ
10_1101-2021_01_08_423993	233	3	difference	difference	NN
10_1101-2021_01_08_423993	233	4	between	between	IN
10_1101-2021_01_08_423993	233	5	our	-PRON-	PRP$
10_1101-2021_01_08_423993	233	6	full	full	JJ
10_1101-2021_01_08_423993	233	7	-	-	HYPH
10_1101-2021_01_08_423993	233	8	length	length	NN
10_1101-2021_01_08_423993	233	9	protein	protein	NN
10_1101-2021_01_08_423993	233	10	and	and	CC
10_1101-2021_01_08_423993	233	11	that	that	WDT
10_1101-2021_01_08_423993	233	12	reported	report	VBN
10_1101-2021_01_08_423993	233	13	by	by	IN
10_1101-2021_01_08_423993	233	14	Ma	Ma	NNP
10_1101-2021_01_08_423993	233	15	et	et	NNP
10_1101-2021_01_08_423993	233	16	.	.	.
10_1101-2021_01_08_423993	234	1	al	al	NNP
10_1101-2021_01_08_423993	234	2	[	[	-LRB-
10_1101-2021_01_08_423993	234	3	18	18	CD
10_1101-2021_01_08_423993	234	4	]	]	-RRB-
10_1101-2021_01_08_423993	234	5	,	,	,
10_1101-2021_01_08_423993	234	6	is	be	VBZ
10_1101-2021_01_08_423993	234	7	that	that	IN
10_1101-2021_01_08_423993	234	8	our	-PRON-	PRP$
10_1101-2021_01_08_423993	234	9	full	full	JJ
10_1101-2021_01_08_423993	234	10	-	-	HYPH
10_1101-2021_01_08_423993	234	11	length	length	NN
10_1101-2021_01_08_423993	234	12	protein	protein	NN
10_1101-2021_01_08_423993	234	13	is	be	VBZ
10_1101-2021_01_08_423993	234	14	active	active	JJ
10_1101-2021_01_08_423993	234	15	in	in	IN
10_1101-2021_01_08_423993	234	16	the	the	DT
10_1101-2021_01_08_423993	234	17	absence	absence	NN
10_1101-2021_01_08_423993	234	18	of	of	IN
10_1101-2021_01_08_423993	234	19	DNA	dna	NN
10_1101-2021_01_08_423993	234	20	-	-	HYPH
10_1101-2021_01_08_423993	234	21	PKcs	pkcs	NN
10_1101-2021_01_08_423993	234	22	.	.	.
10_1101-2021_01_08_423993	235	1	Intact	intact	JJ
10_1101-2021_01_08_423993	235	2	protein	protein	NN
10_1101-2021_01_08_423993	235	3	mass	mass	JJ
10_1101-2021_01_08_423993	235	4	spectrometric	spectrometric	JJ
10_1101-2021_01_08_423993	235	5	analysis	analysis	NN
10_1101-2021_01_08_423993	235	6	of	of	IN
10_1101-2021_01_08_423993	235	7	our	-PRON-	PRP$
10_1101-2021_01_08_423993	235	8	full	full	JJ
10_1101-2021_01_08_423993	235	9	-	-	HYPH
10_1101-2021_01_08_423993	235	10	length	length	NN
10_1101-2021_01_08_423993	235	11	protein	protein	NN
10_1101-2021_01_08_423993	235	12	shows	show	VBZ
10_1101-2021_01_08_423993	235	13	that	that	IN
10_1101-2021_01_08_423993	235	14	the	the	DT
10_1101-2021_01_08_423993	235	15	protein	protein	NN
10_1101-2021_01_08_423993	235	16	has	have	VBZ
10_1101-2021_01_08_423993	235	17	undergone	undergo	VBN
10_1101-2021_01_08_423993	235	18	up	up	RB
10_1101-2021_01_08_423993	235	19	to	to	TO
10_1101-2021_01_08_423993	235	20	five	five	CD
10_1101-2021_01_08_423993	235	21	phosphorylation	phosphorylation	NN
10_1101-2021_01_08_423993	235	22	events	event	NNS
10_1101-2021_01_08_423993	235	23	(	(	-LRB-
10_1101-2021_01_08_423993	235	24	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	235	25	.	.	.
10_1101-2021_01_08_423993	236	1	Figure	figure	NN
10_1101-2021_01_08_423993	236	2	7	7	CD
10_1101-2021_01_08_423993	236	3	)	)	-RRB-
10_1101-2021_01_08_423993	236	4	.	.	.
10_1101-2021_01_08_423993	237	1	Poinsignon	poinsignon	JJ
10_1101-2021_01_08_423993	237	2	et	et	FW
10_1101-2021_01_08_423993	237	3	al	al	NNP
10_1101-2021_01_08_423993	237	4	.	.	.
10_1101-2021_01_08_423993	238	1	have	have	VBP
10_1101-2021_01_08_423993	238	2	shown	show	VBN
10_1101-2021_01_08_423993	238	3	that	that	IN
10_1101-2021_01_08_423993	238	4	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	238	5	is	be	VBZ
10_1101-2021_01_08_423993	238	6	constitutively	constitutively	RB
10_1101-2021_01_08_423993	238	7	phosphorylated	phosphorylate	VBN
10_1101-2021_01_08_423993	238	8	in	in	IN
10_1101-2021_01_08_423993	238	9	cultured	cultured	JJ
10_1101-2021_01_08_423993	238	10	mammalian	mammalian	JJ
10_1101-2021_01_08_423993	238	11	cells	cell	NNS
10_1101-2021_01_08_423993	238	12	and	and	CC
10_1101-2021_01_08_423993	238	13	is	be	VBZ
10_1101-2021_01_08_423993	238	14	the	the	DT
10_1101-2021_01_08_423993	238	15	target	target	NN
10_1101-2021_01_08_423993	238	16	of	of	IN
10_1101-2021_01_08_423993	238	17	additional	additional	JJ
10_1101-2021_01_08_423993	238	18	phosphorylation	phosphorylation	NN
10_1101-2021_01_08_423993	238	19	in	in	IN
10_1101-2021_01_08_423993	238	20	response	response	NN
10_1101-2021_01_08_423993	238	21	to	to	IN
10_1101-2021_01_08_423993	238	22	induced	induce	VBN
10_1101-2021_01_08_423993	238	23	DNA	dna	NN
10_1101-2021_01_08_423993	238	24	damage	damage	NN
10_1101-2021_01_08_423993	238	25	[	[	-LRB-
10_1101-2021_01_08_423993	238	26	61	61	CD
10_1101-2021_01_08_423993	238	27	]	]	-RRB-
10_1101-2021_01_08_423993	238	28	;	;	:
10_1101-2021_01_08_423993	238	29	it	-PRON-	PRP
10_1101-2021_01_08_423993	238	30	is	be	VBZ
10_1101-2021_01_08_423993	238	31	interesting	interesting	JJ
10_1101-2021_01_08_423993	238	32	that	that	IN
10_1101-2021_01_08_423993	238	33	the	the	DT
10_1101-2021_01_08_423993	238	34	capacity	capacity	NN
10_1101-2021_01_08_423993	238	35	to	to	TO
10_1101-2021_01_08_423993	238	36	phosphorylate	phosphorylate	VB
10_1101-2021_01_08_423993	238	37	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	238	38	to	to	TO
10_1101-2021_01_08_423993	238	39	produce	produce	VB
10_1101-2021_01_08_423993	238	40	an	an	DT
10_1101-2021_01_08_423993	238	41	active	active	JJ
10_1101-2021_01_08_423993	238	42	form	form	NN
10_1101-2021_01_08_423993	238	43	is	be	VBZ
10_1101-2021_01_08_423993	238	44	also	also	RB
10_1101-2021_01_08_423993	238	45	conserved	conserve	VBN
10_1101-2021_01_08_423993	238	46	in	in	IN
10_1101-2021_01_08_423993	238	47	insect	insect	JJ
10_1101-2021_01_08_423993	238	48	cells	cell	NNS
10_1101-2021_01_08_423993	238	49	.	.	.
10_1101-2021_01_08_423993	239	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	239	2	observed	observe	VBD
10_1101-2021_01_08_423993	239	3	exonuclease	exonuclease	NN
10_1101-2021_01_08_423993	239	4	activity	activity	NN
10_1101-2021_01_08_423993	239	5	with	with	IN
10_1101-2021_01_08_423993	239	6	full	full	JJ
10_1101-2021_01_08_423993	239	7	-	-	HYPH
10_1101-2021_01_08_423993	239	8	length	length	NN
10_1101-2021_01_08_423993	239	9	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	239	10	at	at	IN
10_1101-2021_01_08_423993	239	11	10	10	CD
10_1101-2021_01_08_423993	239	12	nM	nM	NNP
10_1101-2021_01_08_423993	239	13	(	(	-LRB-
10_1101-2021_01_08_423993	239	14	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	239	15	.	.	.
10_1101-2021_01_08_423993	240	1	Figure	figure	NN
10_1101-2021_01_08_423993	240	2	8)	8)	CD
10_1101-2021_01_08_423993	240	3	,	,	,
10_1101-2021_01_08_423993	240	4	though	though	IN
10_1101-2021_01_08_423993	240	5	this	this	DT
10_1101-2021_01_08_423993	240	6	was	be	VBD
10_1101-2021_01_08_423993	240	7	weak	weak	JJ
10_1101-2021_01_08_423993	240	8	compared	compare	VBN
10_1101-2021_01_08_423993	240	9	to	to	IN
10_1101-2021_01_08_423993	240	10	its	-PRON-	PRP$
10_1101-2021_01_08_423993	240	11	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	240	12	activity	activity	NN
10_1101-2021_01_08_423993	240	13	at	at	IN
10_1101-2021_01_08_423993	240	14	the	the	DT
10_1101-2021_01_08_423993	240	15	same	same	JJ
10_1101-2021_01_08_423993	240	16	concentration	concentration	NN
10_1101-2021_01_08_423993	240	17	.	.	.
10_1101-2021_01_08_423993	241	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	241	2	observed	observe	VBD
10_1101-2021_01_08_423993	241	3	no	no	DT
10_1101-2021_01_08_423993	241	4	exonuclease	exonuclease	NN
10_1101-2021_01_08_423993	241	5	activity	activity	NN
10_1101-2021_01_08_423993	241	6	for	for	IN
10_1101-2021_01_08_423993	241	7	the	the	DT
10_1101-2021_01_08_423993	241	8	truncated	truncate	VBN
10_1101-2021_01_08_423993	241	9	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	241	10	construct	construct	NN
10_1101-2021_01_08_423993	241	11	,	,	,
10_1101-2021_01_08_423993	241	12	it	-PRON-	PRP
10_1101-2021_01_08_423993	241	13	is	be	VBZ
10_1101-2021_01_08_423993	241	14	possible	possible	JJ
10_1101-2021_01_08_423993	241	15	that	that	IN
10_1101-2021_01_08_423993	241	16	phosphorylation	phosphorylation	NN
10_1101-2021_01_08_423993	241	17	alters	alter	VBZ
10_1101-2021_01_08_423993	241	18	the	the	DT
10_1101-2021_01_08_423993	241	19	balance	balance	NN
10_1101-2021_01_08_423993	241	20	between	between	IN
10_1101-2021_01_08_423993	241	21	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	241	22	and	and	CC
10_1101-2021_01_08_423993	241	23	exonuclease	exonuclease	NN
10_1101-2021_01_08_423993	241	24	activity	activity	NN
10_1101-2021_01_08_423993	241	25	,	,	,
10_1101-2021_01_08_423993	241	26	though	though	IN
10_1101-2021_01_08_423993	241	27	the	the	DT
10_1101-2021_01_08_423993	241	28	biological	biological	JJ
10_1101-2021_01_08_423993	241	29	relevance	relevance	NN
10_1101-2021_01_08_423993	241	30	of	of	IN
10_1101-2021_01_08_423993	241	31	this	this	DT
10_1101-2021_01_08_423993	241	32	,	,	,
10_1101-2021_01_08_423993	241	33	if	if	IN
10_1101-2021_01_08_423993	241	34	any	any	DT
10_1101-2021_01_08_423993	241	35	,	,	,
10_1101-2021_01_08_423993	241	36	remains	remain	VBZ
10_1101-2021_01_08_423993	241	37	to	to	TO
10_1101-2021_01_08_423993	241	38	be	be	VB
10_1101-2021_01_08_423993	241	39	validated	validate	VBN
10_1101-2021_01_08_423993	241	40	.	.	.
10_1101-2021_01_08_423993	242	1	As	as	IN
10_1101-2021_01_08_423993	242	2	mentioned	mention	VBN
10_1101-2021_01_08_423993	242	3	above	above	RB
10_1101-2021_01_08_423993	242	4	,	,	,
10_1101-2021_01_08_423993	242	5	both	both	CC
10_1101-2021_01_08_423993	242	6	human	human	JJ
10_1101-2021_01_08_423993	242	7	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	242	8	and	and	CC
10_1101-2021_01_08_423993	242	9	SNM1B	snm1b	PRP
10_1101-2021_01_08_423993	242	10	require	require	VBP
10_1101-2021_01_08_423993	242	11	a	a	DT
10_1101-2021_01_08_423993	242	12	5'-phosphate	5'-phosphate	NNP
10_1101-2021_01_08_423993	242	13	for	for	IN
10_1101-2021_01_08_423993	242	14	their	-PRON-	PRP$
10_1101-2021_01_08_423993	242	15	activity	activity	NN
10_1101-2021_01_08_423993	242	16	[	[	-LRB-
10_1101-2021_01_08_423993	242	17	3,9,15	3,9,15	CD
10_1101-2021_01_08_423993	242	18	]	]	-RRB-
10_1101-2021_01_08_423993	242	19	.	.	.
10_1101-2021_01_08_423993	243	1	To	to	TO
10_1101-2021_01_08_423993	243	2	investigate	investigate	VB
10_1101-2021_01_08_423993	243	3	whether	whether	IN
10_1101-2021_01_08_423993	243	4	there	there	EX
10_1101-2021_01_08_423993	243	5	is	be	VBZ
10_1101-2021_01_08_423993	243	6	a	a	DT
10_1101-2021_01_08_423993	243	7	similar	similar	JJ
10_1101-2021_01_08_423993	243	8	requirement	requirement	NN
10_1101-2021_01_08_423993	243	9	for	for	IN
10_1101-2021_01_08_423993	243	10	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	243	11	,	,	,
10_1101-2021_01_08_423993	243	12	we	-PRON-	PRP
10_1101-2021_01_08_423993	243	13	tested	test	VBD
10_1101-2021_01_08_423993	243	14	the	the	DT
10_1101-2021_01_08_423993	243	15	activity	activity	NN
10_1101-2021_01_08_423993	243	16	of	of	IN
10_1101-2021_01_08_423993	243	17	truncated	truncate	VBN
10_1101-2021_01_08_423993	243	18	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	243	19	against	against	IN
10_1101-2021_01_08_423993	243	20	single	single	JJ
10_1101-2021_01_08_423993	243	21	-	-	HYPH
10_1101-2021_01_08_423993	243	22	stranded	strand	VBN
10_1101-2021_01_08_423993	243	23	and	and	CC
10_1101-2021_01_08_423993	243	24	overhang	overhang	NNP
10_1101-2021_01_08_423993	243	25	DNA	dna	NN
10_1101-2021_01_08_423993	243	26	substrates	substrate	VBZ
10_1101-2021_01_08_423993	243	27	with	with	IN
10_1101-2021_01_08_423993	243	28	different	different	JJ
10_1101-2021_01_08_423993	243	29	5'-end	5'-end	JJ
10_1101-2021_01_08_423993	243	30	groups	group	NNS
10_1101-2021_01_08_423993	243	31	,	,	,
10_1101-2021_01_08_423993	243	32	including	include	VBG
10_1101-2021_01_08_423993	243	33	a	a	DT
10_1101-2021_01_08_423993	243	34	phosphate	phosphate	NN
10_1101-2021_01_08_423993	243	35	,	,	,
10_1101-2021_01_08_423993	243	36	hydroxyl	hydroxyl	NNP
10_1101-2021_01_08_423993	243	37	group	group	NNP
10_1101-2021_01_08_423993	243	38	,	,	,
10_1101-2021_01_08_423993	243	39	and	and	CC
10_1101-2021_01_08_423993	243	40	biotin	biotin	JJ
10_1101-2021_01_08_423993	243	41	groups	group	NNS
10_1101-2021_01_08_423993	243	42	(	(	-LRB-
10_1101-2021_01_08_423993	243	43	Figure	figure	NN
10_1101-2021_01_08_423993	243	44	7A	7a	NN
10_1101-2021_01_08_423993	243	45	)	)	-RRB-
10_1101-2021_01_08_423993	243	46	.	.	.
10_1101-2021_01_08_423993	244	1	The	the	DT
10_1101-2021_01_08_423993	244	2	results	result	NNS
10_1101-2021_01_08_423993	244	3	imply	imply	VBP
10_1101-2021_01_08_423993	244	4	that	that	IN
10_1101-2021_01_08_423993	244	5	,	,	,
10_1101-2021_01_08_423993	244	6	at	at	IN
10_1101-2021_01_08_423993	244	7	least	least	JJS
10_1101-2021_01_08_423993	244	8	under	under	IN
10_1101-2021_01_08_423993	244	9	the	the	DT
10_1101-2021_01_08_423993	244	10	tested	test	VBN
10_1101-2021_01_08_423993	244	11	conditions	condition	NNS
10_1101-2021_01_08_423993	244	12	,	,	,
10_1101-2021_01_08_423993	244	13	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	244	14	is	be	VBZ
10_1101-2021_01_08_423993	244	15	.CC	.CC	:
10_1101-2021_01_08_423993	244	16	-	-	:
10_1101-2021_01_08_423993	244	17	BY	by	IN
10_1101-2021_01_08_423993	244	18	4.0	4.0	CD
10_1101-2021_01_08_423993	244	19	International	international	JJ
10_1101-2021_01_08_423993	244	20	licensemade	licensemade	NN
10_1101-2021_01_08_423993	244	21	available	available	JJ
10_1101-2021_01_08_423993	244	22	under	under	IN
10_1101-2021_01_08_423993	244	23	a	a	DT
10_1101-2021_01_08_423993	244	24	(	(	-LRB-
10_1101-2021_01_08_423993	244	25	which	which	WDT
10_1101-2021_01_08_423993	244	26	was	be	VBD
10_1101-2021_01_08_423993	244	27	not	not	RB
10_1101-2021_01_08_423993	244	28	certified	certify	VBN
10_1101-2021_01_08_423993	244	29	by	by	IN
10_1101-2021_01_08_423993	244	30	peer	peer	NN
10_1101-2021_01_08_423993	244	31	review	review	NN
10_1101-2021_01_08_423993	244	32	)	)	-RRB-
10_1101-2021_01_08_423993	244	33	is	be	VBZ
10_1101-2021_01_08_423993	244	34	the	the	DT
10_1101-2021_01_08_423993	244	35	author	author	NN
10_1101-2021_01_08_423993	244	36	/	/	SYM
10_1101-2021_01_08_423993	244	37	funder	funder	NN
10_1101-2021_01_08_423993	244	38	,	,	,
10_1101-2021_01_08_423993	244	39	who	who	WP
10_1101-2021_01_08_423993	244	40	has	have	VBZ
10_1101-2021_01_08_423993	244	41	granted	grant	VBN
10_1101-2021_01_08_423993	244	42	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	244	43	a	a	DT
10_1101-2021_01_08_423993	244	44	license	license	NN
10_1101-2021_01_08_423993	244	45	to	to	TO
10_1101-2021_01_08_423993	244	46	display	display	VB
10_1101-2021_01_08_423993	244	47	the	the	DT
10_1101-2021_01_08_423993	244	48	preprint	preprint	NN
10_1101-2021_01_08_423993	244	49	in	in	IN
10_1101-2021_01_08_423993	244	50	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	244	51	.	.	.
10_1101-2021_01_08_423993	245	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	245	2	is	be	VBZ
10_1101-2021_01_08_423993	245	3	The	the	DT
10_1101-2021_01_08_423993	245	4	copyright	copyright	NN
10_1101-2021_01_08_423993	245	5	holder	holder	NN
10_1101-2021_01_08_423993	245	6	for	for	IN
10_1101-2021_01_08_423993	245	7	this	this	DT
10_1101-2021_01_08_423993	245	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	245	9	version	version	NN
10_1101-2021_01_08_423993	245	10	posted	post	VBD
10_1101-2021_01_08_423993	245	11	January	January	NNP
10_1101-2021_01_08_423993	245	12	8	8	CD
10_1101-2021_01_08_423993	245	13	,	,	,
10_1101-2021_01_08_423993	245	14	2021	2021	CD
10_1101-2021_01_08_423993	245	15	.	.	.
10_1101-2021_01_08_423993	245	16	;	;	:
10_1101-2021_01_08_423993	245	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	245	18	:	:	:
10_1101-2021_01_08_423993	245	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	245	20	preprint	preprint	NN
10_1101-2021_01_08_423993	245	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	245	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	245	23	agnostic	agnostic	JJ
10_1101-2021_01_08_423993	245	24	to	to	IN
10_1101-2021_01_08_423993	245	25	the	the	DT
10_1101-2021_01_08_423993	245	26	different	different	JJ
10_1101-2021_01_08_423993	245	27	end	end	NN
10_1101-2021_01_08_423993	245	28	modifications	modification	NNS
10_1101-2021_01_08_423993	245	29	,	,	,
10_1101-2021_01_08_423993	245	30	exhibiting	exhibit	VBG
10_1101-2021_01_08_423993	245	31	comparable	comparable	JJ
10_1101-2021_01_08_423993	245	32	digestion	digestion	NN
10_1101-2021_01_08_423993	245	33	of	of	IN
10_1101-2021_01_08_423993	245	34	all	all	DT
10_1101-2021_01_08_423993	245	35	substrates	substrate	NNS
10_1101-2021_01_08_423993	245	36	.	.	.
10_1101-2021_01_08_423993	246	1	Extensive	extensive	JJ
10_1101-2021_01_08_423993	246	2	evidence	evidence	NN
10_1101-2021_01_08_423993	246	3	demonstrates	demonstrate	VBZ
10_1101-2021_01_08_423993	246	4	that	that	IN
10_1101-2021_01_08_423993	246	5	full	full	JJ
10_1101-2021_01_08_423993	246	6	-	-	HYPH
10_1101-2021_01_08_423993	246	7	length	length	NN
10_1101-2021_01_08_423993	246	8	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	246	9	in	in	IN
10_1101-2021_01_08_423993	246	10	complex	complex	NN
10_1101-2021_01_08_423993	246	11	with	with	IN
10_1101-2021_01_08_423993	246	12	DNA	DNA	NNP
10_1101-2021_01_08_423993	246	13	-	-	HYPH
10_1101-2021_01_08_423993	246	14	PKcs	PKcs	NNP
10_1101-2021_01_08_423993	246	15	has	have	VBZ
10_1101-2021_01_08_423993	246	16	structure	structure	NN
10_1101-2021_01_08_423993	246	17	specific	specific	JJ
10_1101-2021_01_08_423993	246	18	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	246	19	activity	activity	NN
10_1101-2021_01_08_423993	246	20	[	[	-LRB-
10_1101-2021_01_08_423993	246	21	17,18,27	17,18,27	NNP
10_1101-2021_01_08_423993	246	22	]	]	-RRB-
10_1101-2021_01_08_423993	246	23	.	.	.
10_1101-2021_01_08_423993	247	1	These	these	DT
10_1101-2021_01_08_423993	247	2	studies	study	NNS
10_1101-2021_01_08_423993	247	3	reported	report	VBD
10_1101-2021_01_08_423993	247	4	that	that	IN
10_1101-2021_01_08_423993	247	5	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	247	6	can	can	MD
10_1101-2021_01_08_423993	247	7	digest	digest	VB
10_1101-2021_01_08_423993	247	8	substrates	substrate	NNS
10_1101-2021_01_08_423993	247	9	including	include	VBG
10_1101-2021_01_08_423993	247	10	overhangs	overhang	NNS
10_1101-2021_01_08_423993	247	11	,	,	,
10_1101-2021_01_08_423993	247	12	hairpins	hairpin	NNS
10_1101-2021_01_08_423993	247	13	,	,	,
10_1101-2021_01_08_423993	247	14	stem	stem	NN
10_1101-2021_01_08_423993	247	15	-	-	HYPH
10_1101-2021_01_08_423993	247	16	loops	loop	NNS
10_1101-2021_01_08_423993	247	17	,	,	,
10_1101-2021_01_08_423993	247	18	and	and	CC
10_1101-2021_01_08_423993	247	19	splayed	splayed	JJ
10_1101-2021_01_08_423993	247	20	arms	arm	NNS
10_1101-2021_01_08_423993	247	21	(	(	-LRB-
10_1101-2021_01_08_423993	247	22	pseudo	pseudo	NNP
10_1101-2021_01_08_423993	247	23	-	-	NNP
10_1101-2021_01_08_423993	247	24	Y	y	NN
10_1101-2021_01_08_423993	247	25	)	)	-RRB-
10_1101-2021_01_08_423993	247	26	.	.	.
10_1101-2021_01_08_423993	248	1	To	to	TO
10_1101-2021_01_08_423993	248	2	investigate	investigate	VB
10_1101-2021_01_08_423993	248	3	the	the	DT
10_1101-2021_01_08_423993	248	4	activity	activity	NN
10_1101-2021_01_08_423993	248	5	of	of	IN
10_1101-2021_01_08_423993	248	6	truncated	truncate	VBN
10_1101-2021_01_08_423993	248	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	248	8	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	248	9	domain	domain	NN
10_1101-2021_01_08_423993	248	10	(	(	-LRB-
10_1101-2021_01_08_423993	248	11	aa	aa	NNP
10_1101-2021_01_08_423993	248	12	1–361	1–361	CD
10_1101-2021_01_08_423993	248	13	)	)	-RRB-
10_1101-2021_01_08_423993	248	14	we	-PRON-	PRP
10_1101-2021_01_08_423993	248	15	performed	perform	VBD
10_1101-2021_01_08_423993	248	16	nuclease	nuclease	NNP
10_1101-2021_01_08_423993	248	17	assays	assays	RB
10_1101-2021_01_08_423993	248	18	using	use	VBG
10_1101-2021_01_08_423993	248	19	a	a	DT
10_1101-2021_01_08_423993	248	20	variety	variety	NN
10_1101-2021_01_08_423993	248	21	of	of	IN
10_1101-2021_01_08_423993	248	22	radio	radio	NN
10_1101-2021_01_08_423993	248	23	-	-	HYPH
10_1101-2021_01_08_423993	248	24	labelled	label	VBN
10_1101-2021_01_08_423993	248	25	DNA	dna	NN
10_1101-2021_01_08_423993	248	26	substrates	substrate	NNS
10_1101-2021_01_08_423993	248	27	(	(	-LRB-
10_1101-2021_01_08_423993	248	28	Figure	figure	NN
10_1101-2021_01_08_423993	248	29	7B	7b	NN
10_1101-2021_01_08_423993	248	30	)	)	-RRB-
10_1101-2021_01_08_423993	248	31	.	.	.
10_1101-2021_01_08_423993	249	1	The	the	DT
10_1101-2021_01_08_423993	249	2	results	result	NNS
10_1101-2021_01_08_423993	249	3	show	show	VBP
10_1101-2021_01_08_423993	249	4	that	that	WDT
10_1101-2021_01_08_423993	249	5	truncated	truncate	VBN
10_1101-2021_01_08_423993	249	6	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	249	7	has	have	VBZ
10_1101-2021_01_08_423993	249	8	substrate	substrate	JJ
10_1101-2021_01_08_423993	249	9	specific	specific	JJ
10_1101-2021_01_08_423993	249	10	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	249	11	activity	activity	NN
10_1101-2021_01_08_423993	249	12	,	,	,
10_1101-2021_01_08_423993	249	13	with	with	IN
10_1101-2021_01_08_423993	249	14	a	a	DT
10_1101-2021_01_08_423993	249	15	preference	preference	NN
10_1101-2021_01_08_423993	249	16	for	for	IN
10_1101-2021_01_08_423993	249	17	single	single	JJ
10_1101-2021_01_08_423993	249	18	-	-	HYPH
10_1101-2021_01_08_423993	249	19	stranded	strand	VBN
10_1101-2021_01_08_423993	249	20	DNA	DNA	NNP
10_1101-2021_01_08_423993	249	21	susbstrates	susbstrate	NNS
10_1101-2021_01_08_423993	249	22	,	,	,
10_1101-2021_01_08_423993	249	23	and	and	CC
10_1101-2021_01_08_423993	249	24	those	those	DT
10_1101-2021_01_08_423993	249	25	that	that	WDT
10_1101-2021_01_08_423993	249	26	contain	contain	VBP
10_1101-2021_01_08_423993	249	27	single	single	JJ
10_1101-2021_01_08_423993	249	28	stranded	strand	VBN
10_1101-2021_01_08_423993	249	29	character	character	NN
10_1101-2021_01_08_423993	249	30	(	(	-LRB-
10_1101-2021_01_08_423993	249	31	e.g.	e.g.	RB
10_1101-2021_01_08_423993	250	1	5’-	5’-	NFP
10_1101-2021_01_08_423993	250	2	and	and	CC
10_1101-2021_01_08_423993	250	3	3’-overhangs	3’-overhangs	CD
10_1101-2021_01_08_423993	250	4	,	,	,
10_1101-2021_01_08_423993	250	5	splayed	splayed	JJ
10_1101-2021_01_08_423993	250	6	arms	arm	NNS
10_1101-2021_01_08_423993	250	7	,	,	,
10_1101-2021_01_08_423993	250	8	and	and	CC
10_1101-2021_01_08_423993	250	9	a	a	DT
10_1101-2021_01_08_423993	250	10	lagging	lag	VBG
10_1101-2021_01_08_423993	250	11	flap	flap	JJ
10_1101-2021_01_08_423993	250	12	structure	structure	NN
10_1101-2021_01_08_423993	250	13	)	)	-RRB-
10_1101-2021_01_08_423993	250	14	,	,	,
10_1101-2021_01_08_423993	250	15	compared	compare	VBN
10_1101-2021_01_08_423993	250	16	with	with	IN
10_1101-2021_01_08_423993	250	17	double	double	JJ
10_1101-2021_01_08_423993	250	18	stranded	strand	VBN
10_1101-2021_01_08_423993	250	19	DNA	dna	NN
10_1101-2021_01_08_423993	250	20	structures	structure	NNS
10_1101-2021_01_08_423993	250	21	(	(	-LRB-
10_1101-2021_01_08_423993	250	22	e.g.	e.g.	RB
10_1101-2021_01_08_423993	251	1	ds	ds	NNP
10_1101-2021_01_08_423993	251	2	DNA	DNA	NNP
10_1101-2021_01_08_423993	251	3	and	and	CC
10_1101-2021_01_08_423993	251	4	a	a	DT
10_1101-2021_01_08_423993	251	5	replication	replication	NN
10_1101-2021_01_08_423993	251	6	fork	fork	NN
10_1101-2021_01_08_423993	251	7	)	)	-RRB-
10_1101-2021_01_08_423993	251	8	.	.	.
10_1101-2021_01_08_423993	252	1	This	this	DT
10_1101-2021_01_08_423993	252	2	is	be	VBZ
10_1101-2021_01_08_423993	252	3	in	in	IN
10_1101-2021_01_08_423993	252	4	accordance	accordance	NN
10_1101-2021_01_08_423993	252	5	with	with	IN
10_1101-2021_01_08_423993	252	6	previous	previous	JJ
10_1101-2021_01_08_423993	252	7	research	research	NN
10_1101-2021_01_08_423993	252	8	,	,	,
10_1101-2021_01_08_423993	252	9	where	where	WRB
10_1101-2021_01_08_423993	252	10	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	252	11	has	have	VBZ
10_1101-2021_01_08_423993	252	12	been	be	VBN
10_1101-2021_01_08_423993	252	13	reported	report	VBN
10_1101-2021_01_08_423993	252	14	to	to	TO
10_1101-2021_01_08_423993	252	15	cleave	cleave	VB
10_1101-2021_01_08_423993	252	16	around	around	RP
10_1101-2021_01_08_423993	252	17	ss-	ss-	CD
10_1101-2021_01_08_423993	252	18	to	to	IN
10_1101-2021_01_08_423993	252	19	dsDNA	dsdna	JJ
10_1101-2021_01_08_423993	252	20	junctions	junction	NNS
10_1101-2021_01_08_423993	252	21	in	in	IN
10_1101-2021_01_08_423993	252	22	DNA	DNA	NNP
10_1101-2021_01_08_423993	252	23	substrates	substrate	NNS
10_1101-2021_01_08_423993	252	24	(	(	-LRB-
10_1101-2021_01_08_423993	252	25	perhaps	perhaps	RB
10_1101-2021_01_08_423993	252	26	cite	cite	VB
10_1101-2021_01_08_423993	252	27	Chang	Chang	NNP
10_1101-2021_01_08_423993	252	28	et	et	FW
10_1101-2021_01_08_423993	252	29	al	al	NNP
10_1101-2021_01_08_423993	252	30	,	,	,
10_1101-2021_01_08_423993	252	31	2015	2015	CD
10_1101-2021_01_08_423993	252	32	for	for	IN
10_1101-2021_01_08_423993	252	33	this	this	DT
10_1101-2021_01_08_423993	252	34	)	)	-RRB-
10_1101-2021_01_08_423993	252	35	.	.	.
10_1101-2021_01_08_423993	253	1	The	the	DT
10_1101-2021_01_08_423993	253	2	truncated	truncated	JJ
10_1101-2021_01_08_423993	253	3	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	253	4	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	253	5	domain	domain	NN
10_1101-2021_01_08_423993	253	6	also	also	RB
10_1101-2021_01_08_423993	253	7	exhibits	exhibit	VBZ
10_1101-2021_01_08_423993	253	8	hairpin	hairpin	VBP
10_1101-2021_01_08_423993	253	9	opening	opening	NN
10_1101-2021_01_08_423993	253	10	activity	activity	NN
10_1101-2021_01_08_423993	253	11	,	,	,
10_1101-2021_01_08_423993	253	12	in	in	IN
10_1101-2021_01_08_423993	253	13	accordance	accordance	NN
10_1101-2021_01_08_423993	253	14	with	with	IN
10_1101-2021_01_08_423993	253	15	what	what	WP
10_1101-2021_01_08_423993	253	16	has	have	VBZ
10_1101-2021_01_08_423993	253	17	previously	previously	RB
10_1101-2021_01_08_423993	253	18	been	be	VBN
10_1101-2021_01_08_423993	253	19	reported	report	VBN
10_1101-2021_01_08_423993	253	20	(	(	-LRB-
10_1101-2021_01_08_423993	253	21	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	253	22	.	.	.
10_1101-2021_01_08_423993	254	1	Fig	fig	NN
10_1101-2021_01_08_423993	254	2	.	.	.
10_1101-2021_01_08_423993	255	1	9	9	LS
10_1101-2021_01_08_423993	255	2	)	)	-RRB-
10_1101-2021_01_08_423993	255	3	.	.	.
10_1101-2021_01_08_423993	256	1	On	on	IN
10_1101-2021_01_08_423993	256	2	a	a	DT
10_1101-2021_01_08_423993	256	3	duplex	duplex	JJ
10_1101-2021_01_08_423993	256	4	substrate	substrate	NN
10_1101-2021_01_08_423993	256	5	(	(	-LRB-
10_1101-2021_01_08_423993	256	6	YM117	ym117	NN
10_1101-2021_01_08_423993	256	7	from	from	IN
10_1101-2021_01_08_423993	256	8	Ma	Ma	NNP
10_1101-2021_01_08_423993	256	9	et	et	FW
10_1101-2021_01_08_423993	256	10	al	al	NNP
10_1101-2021_01_08_423993	256	11	)	)	-RRB-
10_1101-2021_01_08_423993	256	12	[	[	-LRB-
10_1101-2021_01_08_423993	256	13	18	18	CD
10_1101-2021_01_08_423993	256	14	]	]	-RRB-
10_1101-2021_01_08_423993	256	15	with	with	IN
10_1101-2021_01_08_423993	256	16	a	a	DT
10_1101-2021_01_08_423993	256	17	20	20	CD
10_1101-2021_01_08_423993	256	18	nt	nt	RB
10_1101-2021_01_08_423993	256	19	hairpin	hairpin	VB
10_1101-2021_01_08_423993	256	20	region	region	NN
10_1101-2021_01_08_423993	256	21	,	,	,
10_1101-2021_01_08_423993	256	22	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	256	23	cleaves	cleave	VBZ
10_1101-2021_01_08_423993	256	24	adjacent	adjacent	JJ
10_1101-2021_01_08_423993	256	25	to	to	IN
10_1101-2021_01_08_423993	256	26	the	the	DT
10_1101-2021_01_08_423993	256	27	hairpin	hairpin	NN
10_1101-2021_01_08_423993	256	28	,	,	,
10_1101-2021_01_08_423993	256	29	consistent	consistent	JJ
10_1101-2021_01_08_423993	256	30	with	with	IN
10_1101-2021_01_08_423993	256	31	previous	previous	JJ
10_1101-2021_01_08_423993	256	32	data	datum	NNS
10_1101-2021_01_08_423993	256	33	.	.	.
10_1101-2021_01_08_423993	257	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	257	2	is	be	VBZ
10_1101-2021_01_08_423993	257	3	clear	clear	JJ
10_1101-2021_01_08_423993	257	4	that	that	IN
10_1101-2021_01_08_423993	257	5	truncated	truncate	VBN
10_1101-2021_01_08_423993	257	6	form	form	NN
10_1101-2021_01_08_423993	257	7	of	of	IN
10_1101-2021_01_08_423993	257	8	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	257	9	exhibits	exhibit	VBZ
10_1101-2021_01_08_423993	257	10	nuclease	nuclease	NN
10_1101-2021_01_08_423993	257	11	activity	activity	NN
10_1101-2021_01_08_423993	257	12	closely	closely	RB
10_1101-2021_01_08_423993	257	13	comparable	comparable	JJ
10_1101-2021_01_08_423993	257	14	to	to	IN
10_1101-2021_01_08_423993	257	15	the	the	DT
10_1101-2021_01_08_423993	257	16	phosphorylated	phosphorylate	VBN
10_1101-2021_01_08_423993	257	17	full	full	JJ
10_1101-2021_01_08_423993	257	18	-	-	HYPH
10_1101-2021_01_08_423993	257	19	length	length	NN
10_1101-2021_01_08_423993	257	20	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	257	21	protein	protein	NN
10_1101-2021_01_08_423993	257	22	[	[	-LRB-
10_1101-2021_01_08_423993	257	23	18	18	CD
10_1101-2021_01_08_423993	257	24	]	]	-RRB-
10_1101-2021_01_08_423993	257	25	,	,	,
10_1101-2021_01_08_423993	257	26	indicating	indicate	VBG
10_1101-2021_01_08_423993	257	27	that	that	IN
10_1101-2021_01_08_423993	257	28	the	the	DT
10_1101-2021_01_08_423993	257	29	structural	structural	JJ
10_1101-2021_01_08_423993	257	30	studies	study	NNS
10_1101-2021_01_08_423993	257	31	presented	present	VBN
10_1101-2021_01_08_423993	257	32	here	here	RB
10_1101-2021_01_08_423993	257	33	reveal	reveal	VBP
10_1101-2021_01_08_423993	257	34	mechanistic	mechanistic	JJ
10_1101-2021_01_08_423993	257	35	insights	insight	NNS
10_1101-2021_01_08_423993	257	36	of	of	IN
10_1101-2021_01_08_423993	257	37	direct	direct	JJ
10_1101-2021_01_08_423993	257	38	relevance	relevance	NN
10_1101-2021_01_08_423993	257	39	to	to	IN
10_1101-2021_01_08_423993	257	40	the	the	DT
10_1101-2021_01_08_423993	257	41	DNA	DNA	NNP
10_1101-2021_01_08_423993	257	42	-	-	HYPH
10_1101-2021_01_08_423993	257	43	PKcs	pkcs	NN
10_1101-2021_01_08_423993	257	44	-	-	HYPH
10_1101-2021_01_08_423993	257	45	associated	associate	VBN
10_1101-2021_01_08_423993	257	46	form	form	NN
10_1101-2021_01_08_423993	257	47	of	of	IN
10_1101-2021_01_08_423993	257	48	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	257	49	that	that	WDT
10_1101-2021_01_08_423993	257	50	engages	engage	VBZ
10_1101-2021_01_08_423993	257	51	in	in	IN
10_1101-2021_01_08_423993	257	52	end	end	NN
10_1101-2021_01_08_423993	257	53	-	-	HYPH
10_1101-2021_01_08_423993	257	54	processing	processing	NN
10_1101-2021_01_08_423993	257	55	reactions	reaction	NNS
10_1101-2021_01_08_423993	257	56	in	in	IN
10_1101-2021_01_08_423993	257	57	vivo	vivo	NNP
10_1101-2021_01_08_423993	257	58	.	.	.
10_1101-2021_01_08_423993	258	1	Structural	structural	JJ
10_1101-2021_01_08_423993	258	2	and	and	CC
10_1101-2021_01_08_423993	258	3	biochemical	biochemical	JJ
10_1101-2021_01_08_423993	258	4	characterisation	characterisation	NN
10_1101-2021_01_08_423993	258	5	of	of	IN
10_1101-2021_01_08_423993	258	6	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	258	7	point	point	NN
10_1101-2021_01_08_423993	258	8	mutations	mutation	NNS
10_1101-2021_01_08_423993	258	9	Previous	previous	JJ
10_1101-2021_01_08_423993	258	10	site	site	NN
10_1101-2021_01_08_423993	258	11	-	-	HYPH
10_1101-2021_01_08_423993	258	12	directed	direct	VBN
10_1101-2021_01_08_423993	258	13	mutagenesis	mutagenesis	NN
10_1101-2021_01_08_423993	258	14	studies	study	NNS
10_1101-2021_01_08_423993	258	15	by	by	IN
10_1101-2021_01_08_423993	258	16	Pannicke	Pannicke	NNP
10_1101-2021_01_08_423993	258	17	et	et	FW
10_1101-2021_01_08_423993	258	18	al	al	NNP
10_1101-2021_01_08_423993	258	19	.	.	.
10_1101-2021_01_08_423993	259	1	targeting	target	VBG
10_1101-2021_01_08_423993	259	2	the	the	DT
10_1101-2021_01_08_423993	259	3	metal	metal	NN
10_1101-2021_01_08_423993	259	4	ion	ion	NN
10_1101-2021_01_08_423993	259	5	coordinating	coordinate	VBG
10_1101-2021_01_08_423993	259	6	residues	residue	NNS
10_1101-2021_01_08_423993	259	7	in	in	IN
10_1101-2021_01_08_423993	259	8	the	the	DT
10_1101-2021_01_08_423993	259	9	active	active	JJ
10_1101-2021_01_08_423993	259	10	site	site	NN
10_1101-2021_01_08_423993	259	11	(	(	-LRB-
10_1101-2021_01_08_423993	259	12	D17N	d17n	NN
10_1101-2021_01_08_423993	259	13	,	,	,
10_1101-2021_01_08_423993	259	14	H33A	H33A	NNP
10_1101-2021_01_08_423993	259	15	,	,	,
10_1101-2021_01_08_423993	259	16	H35A	H35A	NNP
10_1101-2021_01_08_423993	259	17	,	,	,
10_1101-2021_01_08_423993	259	18	D37N	D37N	NNP
10_1101-2021_01_08_423993	259	19	)	)	-RRB-
10_1101-2021_01_08_423993	259	20	of	of	IN
10_1101-2021_01_08_423993	259	21	full	full	JJ
10_1101-2021_01_08_423993	259	22	-	-	HYPH
10_1101-2021_01_08_423993	259	23	length	length	NN
10_1101-2021_01_08_423993	259	24	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	259	25	(	(	-LRB-
10_1101-2021_01_08_423993	259	26	aa	aa	NNP
10_1101-2021_01_08_423993	259	27	1–692	1–692	NNP
10_1101-2021_01_08_423993	259	28	)	)	-RRB-
10_1101-2021_01_08_423993	259	29	established	establish	VBD
10_1101-2021_01_08_423993	259	30	the	the	DT
10_1101-2021_01_08_423993	259	31	importance	importance	NN
10_1101-2021_01_08_423993	259	32	of	of	IN
10_1101-2021_01_08_423993	259	33	active	active	JJ
10_1101-2021_01_08_423993	259	34	site	site	NN
10_1101-2021_01_08_423993	259	35	motifs	motif	VBZ
10_1101-2021_01_08_423993	259	36	1–4	1–4	CD
10_1101-2021_01_08_423993	259	37	for	for	IN
10_1101-2021_01_08_423993	259	38	activity	activity	NN
10_1101-2021_01_08_423993	259	39	[	[	-LRB-
10_1101-2021_01_08_423993	259	40	27	27	CD
10_1101-2021_01_08_423993	259	41	]	]	-RRB-
10_1101-2021_01_08_423993	259	42	.	.	.
10_1101-2021_01_08_423993	260	1	Each	each	DT
10_1101-2021_01_08_423993	260	2	of	of	IN
10_1101-2021_01_08_423993	260	3	these	these	DT
10_1101-2021_01_08_423993	260	4	substitutions	substitution	NNS
10_1101-2021_01_08_423993	260	5	markedly	markedly	RB
10_1101-2021_01_08_423993	260	6	reduced	reduce	VBN
10_1101-2021_01_08_423993	260	7	or	or	CC
10_1101-2021_01_08_423993	260	8	abolished	abolish	VBD
10_1101-2021_01_08_423993	260	9	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	260	10	’	'	''
10_1101-2021_01_08_423993	260	11	ability	ability	NN
10_1101-2021_01_08_423993	260	12	to	to	TO
10_1101-2021_01_08_423993	260	13	carry	carry	VB
10_1101-2021_01_08_423993	260	14	out	out	RP
10_1101-2021_01_08_423993	260	15	its	-PRON-	PRP$
10_1101-2021_01_08_423993	260	16	role	role	NN
10_1101-2021_01_08_423993	260	17	in	in	IN
10_1101-2021_01_08_423993	260	18	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	260	19	recombination	recombination	NN
10_1101-2021_01_08_423993	260	20	in	in	IN
10_1101-2021_01_08_423993	260	21	vitro	vitro	FW
10_1101-2021_01_08_423993	260	22	.	.	.
10_1101-2021_01_08_423993	261	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	261	2	mutated	mutate	VBD
10_1101-2021_01_08_423993	261	3	,	,	,
10_1101-2021_01_08_423993	261	4	expressed	express	VBD
10_1101-2021_01_08_423993	261	5	,	,	,
10_1101-2021_01_08_423993	261	6	purified	purify	VBN
10_1101-2021_01_08_423993	261	7	,	,	,
10_1101-2021_01_08_423993	261	8	and	and	CC
10_1101-2021_01_08_423993	261	9	crystallised	crystallise	VBD
10_1101-2021_01_08_423993	261	10	three	three	CD
10_1101-2021_01_08_423993	261	11	forms	form	NNS
10_1101-2021_01_08_423993	261	12	of	of	IN
10_1101-2021_01_08_423993	261	13	truncated	truncate	VBN
10_1101-2021_01_08_423993	261	14	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	261	15	(	(	-LRB-
10_1101-2021_01_08_423993	261	16	aa	aa	NNP
10_1101-2021_01_08_423993	261	17	1–361	1–361	CD
10_1101-2021_01_08_423993	261	18	)	)	-RRB-
10_1101-2021_01_08_423993	261	19	with	with	IN
10_1101-2021_01_08_423993	261	20	substitutions	substitution	NNS
10_1101-2021_01_08_423993	261	21	in	in	IN
10_1101-2021_01_08_423993	261	22	several	several	JJ
10_1101-2021_01_08_423993	261	23	of	of	IN
10_1101-2021_01_08_423993	261	24	these	these	DT
10_1101-2021_01_08_423993	261	25	metal	metal	NN
10_1101-2021_01_08_423993	261	26	ion	ion	NN
10_1101-2021_01_08_423993	261	27	co	co	NN
10_1101-2021_01_08_423993	261	28	-	-	JJ
10_1101-2021_01_08_423993	261	29	ordinating	ordinating	JJ
10_1101-2021_01_08_423993	261	30	residues	residue	NNS
10_1101-2021_01_08_423993	261	31	,	,	,
10_1101-2021_01_08_423993	261	32	i.e.	i.e.	FW
10_1101-2021_01_08_423993	262	1	D37A	d37a	JJ
10_1101-2021_01_08_423993	262	2	,	,	,
10_1101-2021_01_08_423993	262	3	H33A	H33A	NNP
10_1101-2021_01_08_423993	262	4	,	,	,
10_1101-2021_01_08_423993	262	5	and	and	CC
10_1101-2021_01_08_423993	262	6	the	the	DT
10_1101-2021_01_08_423993	262	7	Omenn	Omenn	NNP
10_1101-2021_01_08_423993	262	8	Syndrome	Syndrome	NNP
10_1101-2021_01_08_423993	262	9	patient	patient	NN
10_1101-2021_01_08_423993	262	10	mutation	mutation	NN
10_1101-2021_01_08_423993	262	11	H35D	H35D	NNP
10_1101-2021_01_08_423993	262	12	[	[	-LRB-
10_1101-2021_01_08_423993	262	13	31,55	31,55	CD
10_1101-2021_01_08_423993	262	14	]	]	-RRB-
10_1101-2021_01_08_423993	262	15	.	.	.
10_1101-2021_01_08_423993	263	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	263	2	found	find	VBD
10_1101-2021_01_08_423993	263	3	that	that	IN
10_1101-2021_01_08_423993	263	4	the	the	DT
10_1101-2021_01_08_423993	263	5	overall	overall	JJ
10_1101-2021_01_08_423993	263	6	architecture	architecture	NN
10_1101-2021_01_08_423993	263	7	of	of	IN
10_1101-2021_01_08_423993	263	8	the	the	DT
10_1101-2021_01_08_423993	263	9	three	three	CD
10_1101-2021_01_08_423993	263	10	variants	variant	NNS
10_1101-2021_01_08_423993	263	11	is	be	VBZ
10_1101-2021_01_08_423993	263	12	almost	almost	RB
10_1101-2021_01_08_423993	263	13	identical	identical	JJ
10_1101-2021_01_08_423993	263	14	to	to	IN
10_1101-2021_01_08_423993	263	15	the	the	DT
10_1101-2021_01_08_423993	263	16	WT	WT	NNP
10_1101-2021_01_08_423993	263	17	(	(	-LRB-
10_1101-2021_01_08_423993	263	18	Figure	Figure	NNP
10_1101-2021_01_08_423993	263	19	8A	8A	NNP
10_1101-2021_01_08_423993	263	20	)	)	-RRB-
10_1101-2021_01_08_423993	263	21	.	.	.
10_1101-2021_01_08_423993	264	1	The	the	DT
10_1101-2021_01_08_423993	264	2	D37A	D37A	NNP
10_1101-2021_01_08_423993	264	3	structure	structure	NN
10_1101-2021_01_08_423993	264	4	retains	retain	VBZ
10_1101-2021_01_08_423993	264	5	one	one	CD
10_1101-2021_01_08_423993	264	6	Zn	zn	IN
10_1101-2021_01_08_423993	264	7	ion	ion	NN
10_1101-2021_01_08_423993	264	8	(	(	-LRB-
10_1101-2021_01_08_423993	264	9	Zn1	zn1	NN
10_1101-2021_01_08_423993	264	10	)	)	-RRB-
10_1101-2021_01_08_423993	264	11	whilst	whilst	IN
10_1101-2021_01_08_423993	264	12	losing	lose	VBG
10_1101-2021_01_08_423993	264	13	the	the	DT
10_1101-2021_01_08_423993	264	14	second	second	NN
10_1101-2021_01_08_423993	264	15	,	,	,
10_1101-2021_01_08_423993	264	16	(	(	-LRB-
10_1101-2021_01_08_423993	264	17	Zn2	Zn2	NNP
10_1101-2021_01_08_423993	264	18	)	)	-RRB-
10_1101-2021_01_08_423993	264	19	(	(	-LRB-
10_1101-2021_01_08_423993	264	20	Figure	figure	NN
10_1101-2021_01_08_423993	264	21	8B	8b	NN
10_1101-2021_01_08_423993	264	22	)	)	-RRB-
10_1101-2021_01_08_423993	264	23	in	in	IN
10_1101-2021_01_08_423993	264	24	the	the	DT
10_1101-2021_01_08_423993	264	25	active	active	JJ
10_1101-2021_01_08_423993	264	26	site	site	NN
10_1101-2021_01_08_423993	264	27	.	.	.
10_1101-2021_01_08_423993	265	1	Both	both	CC
10_1101-2021_01_08_423993	265	2	the	the	DT
10_1101-2021_01_08_423993	265	3	H33A	H33A	NNP
10_1101-2021_01_08_423993	265	4	and	and	CC
10_1101-2021_01_08_423993	265	5	H35D	H35D	NNP
10_1101-2021_01_08_423993	265	6	variants	variant	NNS
10_1101-2021_01_08_423993	265	7	additionally	additionally	RB
10_1101-2021_01_08_423993	265	8	exhibited	exhibit	VBD
10_1101-2021_01_08_423993	265	9	loss	loss	NN
10_1101-2021_01_08_423993	265	10	of	of	IN
10_1101-2021_01_08_423993	265	11	the	the	DT
10_1101-2021_01_08_423993	265	12	Zn1	zn1	NN
10_1101-2021_01_08_423993	265	13	ion	ion	NN
10_1101-2021_01_08_423993	265	14	.	.	.
10_1101-2021_01_08_423993	266	1	All	all	DT
10_1101-2021_01_08_423993	266	2	three	three	CD
10_1101-2021_01_08_423993	266	3	variants	variant	NNS
10_1101-2021_01_08_423993	266	4	retained	retain	VBD
10_1101-2021_01_08_423993	266	5	the	the	DT
10_1101-2021_01_08_423993	266	6	Zn	Zn	NNP
10_1101-2021_01_08_423993	266	7	ion	ion	NN
10_1101-2021_01_08_423993	266	8	in	in	IN
10_1101-2021_01_08_423993	266	9	the	the	DT
10_1101-2021_01_08_423993	266	10	zinc	zinc	NN
10_1101-2021_01_08_423993	266	11	finger	finger	NN
10_1101-2021_01_08_423993	266	12	-	-	HYPH
10_1101-2021_01_08_423993	266	13	like	like	JJ
10_1101-2021_01_08_423993	266	14	motif	motif	NN
10_1101-2021_01_08_423993	266	15	of	of	IN
10_1101-2021_01_08_423993	266	16	the	the	DT
10_1101-2021_01_08_423993	266	17	β	β	NNP
10_1101-2021_01_08_423993	266	18	-	-	HYPH
10_1101-2021_01_08_423993	266	19	CASP	CASP	NNP
10_1101-2021_01_08_423993	266	20	domain	domain	NN
10_1101-2021_01_08_423993	266	21	.	.	.
10_1101-2021_01_08_423993	267	1	The	the	DT
10_1101-2021_01_08_423993	267	2	position	position	NN
10_1101-2021_01_08_423993	267	3	of	of	IN
10_1101-2021_01_08_423993	267	4	the	the	DT
10_1101-2021_01_08_423993	267	5	active	active	JJ
10_1101-2021_01_08_423993	267	6	site	site	NN
10_1101-2021_01_08_423993	267	7	residues	residue	NNS
10_1101-2021_01_08_423993	267	8	and	and	CC
10_1101-2021_01_08_423993	267	9	the	the	DT
10_1101-2021_01_08_423993	267	10	surrounding	surround	VBG
10_1101-2021_01_08_423993	267	11	residues	residue	NNS
10_1101-2021_01_08_423993	267	12	in	in	IN
10_1101-2021_01_08_423993	267	13	the	the	DT
10_1101-2021_01_08_423993	267	14	D37A	D37A	NNP
10_1101-2021_01_08_423993	267	15	variant	variant	NN
10_1101-2021_01_08_423993	267	16	,	,	,
10_1101-2021_01_08_423993	267	17	superposed	superpose	VBN
10_1101-2021_01_08_423993	267	18	perfectly	perfectly	RB
10_1101-2021_01_08_423993	267	19	with	with	IN
10_1101-2021_01_08_423993	267	20	WT	WT	NNP
10_1101-2021_01_08_423993	267	21	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	267	22	.	.	.
10_1101-2021_01_08_423993	268	1	As	as	IN
10_1101-2021_01_08_423993	268	2	previously	previously	RB
10_1101-2021_01_08_423993	268	3	mentioned	mention	VBN
10_1101-2021_01_08_423993	268	4	,	,	,
10_1101-2021_01_08_423993	268	5	Asp37	Asp37	NNP
10_1101-2021_01_08_423993	268	6	can	can	MD
10_1101-2021_01_08_423993	268	7	adopt	adopt	VB
10_1101-2021_01_08_423993	268	8	two	two	CD
10_1101-2021_01_08_423993	268	9	conformations	conformation	NNS
10_1101-2021_01_08_423993	268	10	as	as	IN
10_1101-2021_01_08_423993	268	11	seen	see	VBN
10_1101-2021_01_08_423993	268	12	in	in	IN
10_1101-2021_01_08_423993	268	13	6TT5	6tt5	CD
10_1101-2021_01_08_423993	268	14	structure	structure	NN
10_1101-2021_01_08_423993	268	15	,	,	,
10_1101-2021_01_08_423993	268	16	noting	note	VBG
10_1101-2021_01_08_423993	268	17	that	that	IN
10_1101-2021_01_08_423993	268	18	the	the	DT
10_1101-2021_01_08_423993	268	19	coordinated	coordinated	JJ
10_1101-2021_01_08_423993	268	20	zinc	zinc	NN
10_1101-2021_01_08_423993	268	21	ion	ion	NN
10_1101-2021_01_08_423993	268	22	is	be	VBZ
10_1101-2021_01_08_423993	268	23	generally	generally	RB
10_1101-2021_01_08_423993	268	24	present	present	JJ
10_1101-2021_01_08_423993	268	25	at	at	IN
10_1101-2021_01_08_423993	268	26	about	about	RB
10_1101-2021_01_08_423993	268	27	30	30	CD
10_1101-2021_01_08_423993	268	28	%	%	NN
10_1101-2021_01_08_423993	268	29	occupancy	occupancy	NN
10_1101-2021_01_08_423993	268	30	in	in	IN
10_1101-2021_01_08_423993	268	31	both	both	DT
10_1101-2021_01_08_423993	268	32	of	of	IN
10_1101-2021_01_08_423993	268	33	the	the	DT
10_1101-2021_01_08_423993	268	34	WT	WT	NNP
10_1101-2021_01_08_423993	268	35	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	268	36	structures	structure	NNS
10_1101-2021_01_08_423993	268	37	(	(	-LRB-
10_1101-2021_01_08_423993	268	38	PDB	PDB	NNP
10_1101-2021_01_08_423993	268	39	6TT5	6TT5	NNPS
10_1101-2021_01_08_423993	268	40	and	and	CC
10_1101-2021_01_08_423993	268	41	7AF1	7af1	CD
10_1101-2021_01_08_423993	268	42	)	)	-RRB-
10_1101-2021_01_08_423993	268	43	.	.	.
10_1101-2021_01_08_423993	269	1	.CC	.CC	NFP
10_1101-2021_01_08_423993	269	2	-	-	:
10_1101-2021_01_08_423993	269	3	BY	by	IN
10_1101-2021_01_08_423993	269	4	4.0	4.0	CD
10_1101-2021_01_08_423993	269	5	International	international	JJ
10_1101-2021_01_08_423993	269	6	licensemade	licensemade	NN
10_1101-2021_01_08_423993	269	7	available	available	JJ
10_1101-2021_01_08_423993	269	8	under	under	IN
10_1101-2021_01_08_423993	269	9	a	a	DT
10_1101-2021_01_08_423993	269	10	(	(	-LRB-
10_1101-2021_01_08_423993	269	11	which	which	WDT
10_1101-2021_01_08_423993	269	12	was	be	VBD
10_1101-2021_01_08_423993	269	13	not	not	RB
10_1101-2021_01_08_423993	269	14	certified	certify	VBN
10_1101-2021_01_08_423993	269	15	by	by	IN
10_1101-2021_01_08_423993	269	16	peer	peer	NN
10_1101-2021_01_08_423993	269	17	review	review	NN
10_1101-2021_01_08_423993	269	18	)	)	-RRB-
10_1101-2021_01_08_423993	269	19	is	be	VBZ
10_1101-2021_01_08_423993	269	20	the	the	DT
10_1101-2021_01_08_423993	269	21	author	author	NN
10_1101-2021_01_08_423993	269	22	/	/	SYM
10_1101-2021_01_08_423993	269	23	funder	funder	NN
10_1101-2021_01_08_423993	269	24	,	,	,
10_1101-2021_01_08_423993	269	25	who	who	WP
10_1101-2021_01_08_423993	269	26	has	have	VBZ
10_1101-2021_01_08_423993	269	27	granted	grant	VBN
10_1101-2021_01_08_423993	269	28	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	269	29	a	a	DT
10_1101-2021_01_08_423993	269	30	license	license	NN
10_1101-2021_01_08_423993	269	31	to	to	TO
10_1101-2021_01_08_423993	269	32	display	display	VB
10_1101-2021_01_08_423993	269	33	the	the	DT
10_1101-2021_01_08_423993	269	34	preprint	preprint	NN
10_1101-2021_01_08_423993	269	35	in	in	IN
10_1101-2021_01_08_423993	269	36	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	269	37	.	.	.
10_1101-2021_01_08_423993	270	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	270	2	is	be	VBZ
10_1101-2021_01_08_423993	270	3	The	the	DT
10_1101-2021_01_08_423993	270	4	copyright	copyright	NN
10_1101-2021_01_08_423993	270	5	holder	holder	NN
10_1101-2021_01_08_423993	270	6	for	for	IN
10_1101-2021_01_08_423993	270	7	this	this	DT
10_1101-2021_01_08_423993	270	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	270	9	version	version	NN
10_1101-2021_01_08_423993	270	10	posted	post	VBD
10_1101-2021_01_08_423993	270	11	January	January	NNP
10_1101-2021_01_08_423993	270	12	8	8	CD
10_1101-2021_01_08_423993	270	13	,	,	,
10_1101-2021_01_08_423993	270	14	2021	2021	CD
10_1101-2021_01_08_423993	270	15	.	.	.
10_1101-2021_01_08_423993	270	16	;	;	:
10_1101-2021_01_08_423993	270	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	270	18	:	:	:
10_1101-2021_01_08_423993	270	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	270	20	preprint	preprint	NN
10_1101-2021_01_08_423993	270	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	270	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	270	23	Therefore	therefore	RB
10_1101-2021_01_08_423993	270	24	,	,	,
10_1101-2021_01_08_423993	270	25	it	-PRON-	PRP
10_1101-2021_01_08_423993	270	26	is	be	VBZ
10_1101-2021_01_08_423993	270	27	unsurprising	unsurprise	VBG
10_1101-2021_01_08_423993	270	28	that	that	DT
10_1101-2021_01_08_423993	270	29	mutation	mutation	NN
10_1101-2021_01_08_423993	270	30	of	of	IN
10_1101-2021_01_08_423993	270	31	Asp37	Asp37	NNP
10_1101-2021_01_08_423993	270	32	to	to	TO
10_1101-2021_01_08_423993	270	33	alanine	alanine	VB
10_1101-2021_01_08_423993	270	34	results	result	NNS
10_1101-2021_01_08_423993	270	35	in	in	IN
10_1101-2021_01_08_423993	270	36	the	the	DT
10_1101-2021_01_08_423993	270	37	loss	loss	NN
10_1101-2021_01_08_423993	270	38	of	of	IN
10_1101-2021_01_08_423993	270	39	Zn2	Zn2	NNP
10_1101-2021_01_08_423993	270	40	.	.	.
10_1101-2021_01_08_423993	271	1	Differential	differential	NN
10_1101-2021_01_08_423993	271	2	scanning	scanning	NN
10_1101-2021_01_08_423993	271	3	fluorimetry	fluorimetry	NN
10_1101-2021_01_08_423993	271	4	(	(	-LRB-
10_1101-2021_01_08_423993	271	5	DSF	DSF	NNP
10_1101-2021_01_08_423993	271	6	)	)	-RRB-
10_1101-2021_01_08_423993	271	7	experiments	experiment	NNS
10_1101-2021_01_08_423993	271	8	were	be	VBD
10_1101-2021_01_08_423993	271	9	carried	carry	VBN
10_1101-2021_01_08_423993	271	10	out	out	RP
10_1101-2021_01_08_423993	271	11	to	to	TO
10_1101-2021_01_08_423993	271	12	investigate	investigate	VB
10_1101-2021_01_08_423993	271	13	the	the	DT
10_1101-2021_01_08_423993	271	14	stability	stability	NN
10_1101-2021_01_08_423993	271	15	of	of	IN
10_1101-2021_01_08_423993	271	16	the	the	DT
10_1101-2021_01_08_423993	271	17	three	three	CD
10_1101-2021_01_08_423993	271	18	variants	variant	NNS
10_1101-2021_01_08_423993	271	19	.	.	.
10_1101-2021_01_08_423993	272	1	DSF	DSF	NNP
10_1101-2021_01_08_423993	272	2	analysis	analysis	NN
10_1101-2021_01_08_423993	272	3	showed	show	VBD
10_1101-2021_01_08_423993	272	4	that	that	IN
10_1101-2021_01_08_423993	272	5	the	the	DT
10_1101-2021_01_08_423993	272	6	D37A	D37A	NNP
10_1101-2021_01_08_423993	272	7	variant	variant	NN
10_1101-2021_01_08_423993	272	8	has	have	VBZ
10_1101-2021_01_08_423993	272	9	similar	similar	JJ
10_1101-2021_01_08_423993	272	10	thermal	thermal	JJ
10_1101-2021_01_08_423993	272	11	stability	stability	NN
10_1101-2021_01_08_423993	272	12	as	as	IN
10_1101-2021_01_08_423993	272	13	the	the	DT
10_1101-2021_01_08_423993	272	14	WT	WT	NNP
10_1101-2021_01_08_423993	272	15	,	,	,
10_1101-2021_01_08_423993	272	16	suggesting	suggest	VBG
10_1101-2021_01_08_423993	272	17	that	that	IN
10_1101-2021_01_08_423993	272	18	the	the	DT
10_1101-2021_01_08_423993	272	19	protein	protein	NN
10_1101-2021_01_08_423993	272	20	is	be	VBZ
10_1101-2021_01_08_423993	272	21	stable	stable	JJ
10_1101-2021_01_08_423993	272	22	and	and	CC
10_1101-2021_01_08_423993	272	23	folded	fold	VBN
10_1101-2021_01_08_423993	272	24	in	in	IN
10_1101-2021_01_08_423993	272	25	the	the	DT
10_1101-2021_01_08_423993	272	26	presence	presence	NN
10_1101-2021_01_08_423993	272	27	of	of	IN
10_1101-2021_01_08_423993	272	28	a	a	DT
10_1101-2021_01_08_423993	272	29	single	single	JJ
10_1101-2021_01_08_423993	272	30	metal	metal	NN
10_1101-2021_01_08_423993	272	31	ion	ion	NN
10_1101-2021_01_08_423993	272	32	in	in	IN
10_1101-2021_01_08_423993	272	33	the	the	DT
10_1101-2021_01_08_423993	272	34	active	active	JJ
10_1101-2021_01_08_423993	272	35	site	site	NN
10_1101-2021_01_08_423993	272	36	,	,	,
10_1101-2021_01_08_423993	272	37	whilst	whilst	IN
10_1101-2021_01_08_423993	272	38	both	both	CC
10_1101-2021_01_08_423993	272	39	H33A	H33A	NNP
10_1101-2021_01_08_423993	272	40	and	and	CC
10_1101-2021_01_08_423993	272	41	H35D	H35D	NNP
10_1101-2021_01_08_423993	272	42	variants	variant	NNS
10_1101-2021_01_08_423993	272	43	were	be	VBD
10_1101-2021_01_08_423993	272	44	substantially	substantially	RB
10_1101-2021_01_08_423993	272	45	destabilized	destabilize	VBN
10_1101-2021_01_08_423993	272	46	with	with	IN
10_1101-2021_01_08_423993	272	47	ΔTm	ΔTm	NNS
10_1101-2021_01_08_423993	272	48	around	around	IN
10_1101-2021_01_08_423993	272	49	-13	-13	HYPH
10_1101-2021_01_08_423993	272	50	°	°	NNS
10_1101-2021_01_08_423993	272	51	C	C	NNP
10_1101-2021_01_08_423993	272	52	compared	compare	VBN
10_1101-2021_01_08_423993	272	53	to	to	IN
10_1101-2021_01_08_423993	272	54	the	the	DT
10_1101-2021_01_08_423993	272	55	WT	WT	NNP
10_1101-2021_01_08_423993	272	56	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	272	57	(	(	-LRB-
10_1101-2021_01_08_423993	272	58	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	272	59	.	.	.
10_1101-2021_01_08_423993	273	1	Figure	figure	NN
10_1101-2021_01_08_423993	273	2	10	10	CD
10_1101-2021_01_08_423993	273	3	)	)	-RRB-
10_1101-2021_01_08_423993	273	4	.	.	.
10_1101-2021_01_08_423993	274	1	Histidines	Histidines	NNP
10_1101-2021_01_08_423993	274	2	33	33	CD
10_1101-2021_01_08_423993	274	3	and	and	CC
10_1101-2021_01_08_423993	274	4	35	35	CD
10_1101-2021_01_08_423993	274	5	are	be	VBP
10_1101-2021_01_08_423993	274	6	the	the	DT
10_1101-2021_01_08_423993	274	7	first	first	JJ
10_1101-2021_01_08_423993	274	8	two	two	CD
10_1101-2021_01_08_423993	274	9	histidine	histidine	NN
10_1101-2021_01_08_423993	274	10	residues	residue	NNS
10_1101-2021_01_08_423993	274	11	in	in	IN
10_1101-2021_01_08_423993	274	12	the	the	DT
10_1101-2021_01_08_423993	274	13	HxHxDH	hxhxdh	JJ
10_1101-2021_01_08_423993	274	14	motif	motif	NN
10_1101-2021_01_08_423993	274	15	(	(	-LRB-
10_1101-2021_01_08_423993	274	16	motif	motif	NN
10_1101-2021_01_08_423993	274	17	2	2	CD
10_1101-2021_01_08_423993	274	18	)	)	-RRB-
10_1101-2021_01_08_423993	274	19	in	in	IN
10_1101-2021_01_08_423993	274	20	the	the	DT
10_1101-2021_01_08_423993	274	21	MBL	MBL	NNP
10_1101-2021_01_08_423993	274	22	domain	domain	NN
10_1101-2021_01_08_423993	274	23	.	.	.
10_1101-2021_01_08_423993	275	1	Their	-PRON-	PRP$
10_1101-2021_01_08_423993	275	2	role	role	NN
10_1101-2021_01_08_423993	275	3	is	be	VBZ
10_1101-2021_01_08_423993	275	4	to	to	TO
10_1101-2021_01_08_423993	275	5	coordinate	coordinate	VB
10_1101-2021_01_08_423993	275	6	the	the	DT
10_1101-2021_01_08_423993	275	7	first	first	JJ
10_1101-2021_01_08_423993	275	8	metal	metal	NN
10_1101-2021_01_08_423993	275	9	ion	ion	NN
10_1101-2021_01_08_423993	275	10	(	(	-LRB-
10_1101-2021_01_08_423993	275	11	Zn1	zn1	NN
10_1101-2021_01_08_423993	275	12	site	site	NN
10_1101-2021_01_08_423993	275	13	)	)	-RRB-
10_1101-2021_01_08_423993	275	14	in	in	IN
10_1101-2021_01_08_423993	275	15	the	the	DT
10_1101-2021_01_08_423993	275	16	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	275	17	site	site	NN
10_1101-2021_01_08_423993	275	18	.	.	.
10_1101-2021_01_08_423993	276	1	In	in	IN
10_1101-2021_01_08_423993	276	2	the	the	DT
10_1101-2021_01_08_423993	276	3	absence	absence	NN
10_1101-2021_01_08_423993	276	4	of	of	IN
10_1101-2021_01_08_423993	276	5	metal	metal	NN
10_1101-2021_01_08_423993	276	6	ions	ion	NNS
10_1101-2021_01_08_423993	276	7	in	in	IN
10_1101-2021_01_08_423993	276	8	the	the	DT
10_1101-2021_01_08_423993	276	9	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	276	10	site	site	NN
10_1101-2021_01_08_423993	276	11	,	,	,
10_1101-2021_01_08_423993	276	12	the	the	DT
10_1101-2021_01_08_423993	276	13	loop	loop	NN
10_1101-2021_01_08_423993	276	14	comprising	comprise	VBG
10_1101-2021_01_08_423993	276	15	residues	residue	VBZ
10_1101-2021_01_08_423993	276	16	113–119	113–119	CD
10_1101-2021_01_08_423993	276	17	moves	move	NNS
10_1101-2021_01_08_423993	276	18	away	away	RB
10_1101-2021_01_08_423993	276	19	from	from	IN
10_1101-2021_01_08_423993	276	20	the	the	DT
10_1101-2021_01_08_423993	276	21	active	active	JJ
10_1101-2021_01_08_423993	276	22	site	site	NN
10_1101-2021_01_08_423993	276	23	(	(	-LRB-
10_1101-2021_01_08_423993	276	24	Figure	figure	NN
10_1101-2021_01_08_423993	276	25	8C	8c	NN
10_1101-2021_01_08_423993	276	26	and	and	CC
10_1101-2021_01_08_423993	276	27	D	d	NN
10_1101-2021_01_08_423993	276	28	)	)	-RRB-
10_1101-2021_01_08_423993	276	29	.	.	.
10_1101-2021_01_08_423993	277	1	Another	another	DT
10_1101-2021_01_08_423993	277	2	small	small	JJ
10_1101-2021_01_08_423993	277	3	rearrangement	rearrangement	NN
10_1101-2021_01_08_423993	277	4	occurs	occur	VBZ
10_1101-2021_01_08_423993	277	5	in	in	IN
10_1101-2021_01_08_423993	277	6	helix	helix	NN
10_1101-2021_01_08_423993	277	7	α8	α8	NN
10_1101-2021_01_08_423993	277	8	(	(	-LRB-
10_1101-2021_01_08_423993	277	9	residues	residue	NNS
10_1101-2021_01_08_423993	277	10	348–358	348–358	CD
10_1101-2021_01_08_423993	277	11	)	)	-RRB-
10_1101-2021_01_08_423993	277	12	of	of	IN
10_1101-2021_01_08_423993	277	13	the	the	DT
10_1101-2021_01_08_423993	277	14	MBL	MBL	NNP
10_1101-2021_01_08_423993	277	15	domain	domain	NN
10_1101-2021_01_08_423993	277	16	.	.	.
10_1101-2021_01_08_423993	278	1	In	in	IN
10_1101-2021_01_08_423993	278	2	both	both	CC
10_1101-2021_01_08_423993	278	3	the	the	DT
10_1101-2021_01_08_423993	278	4	H33A	H33A	NNP
10_1101-2021_01_08_423993	278	5	and	and	CC
10_1101-2021_01_08_423993	278	6	H35D	H35D	NNP
10_1101-2021_01_08_423993	278	7	variants	variant	NNS
10_1101-2021_01_08_423993	278	8	,	,	,
10_1101-2021_01_08_423993	278	9	helix	helix	NN
10_1101-2021_01_08_423993	278	10	α8	α8	NN
10_1101-2021_01_08_423993	278	11	moves	move	VBZ
10_1101-2021_01_08_423993	278	12	slightly	slightly	RB
10_1101-2021_01_08_423993	278	13	closer	close	RBR
10_1101-2021_01_08_423993	278	14	toward	toward	IN
10_1101-2021_01_08_423993	278	15	strand	strand	NNP
10_1101-2021_01_08_423993	278	16	β14	β14	NNP
10_1101-2021_01_08_423993	278	17	,	,	,
10_1101-2021_01_08_423993	278	18	compared	compare	VBN
10_1101-2021_01_08_423993	278	19	to	to	IN
10_1101-2021_01_08_423993	278	20	the	the	DT
10_1101-2021_01_08_423993	278	21	WT	WT	NNP
10_1101-2021_01_08_423993	278	22	and	and	CC
10_1101-2021_01_08_423993	278	23	D37A	D37A	NNP
10_1101-2021_01_08_423993	278	24	variant	variant	JJ
10_1101-2021_01_08_423993	278	25	.	.	.
10_1101-2021_01_08_423993	279	1	Surprisingly	surprisingly	RB
10_1101-2021_01_08_423993	279	2	,	,	,
10_1101-2021_01_08_423993	279	3	the	the	DT
10_1101-2021_01_08_423993	279	4	biggest	big	JJS
10_1101-2021_01_08_423993	279	5	rearrangement	rearrangement	NN
10_1101-2021_01_08_423993	279	6	occurs	occur	VBZ
10_1101-2021_01_08_423993	279	7	in	in	IN
10_1101-2021_01_08_423993	279	8	β	β	NNP
10_1101-2021_01_08_423993	279	9	-	-	HYPH
10_1101-2021_01_08_423993	279	10	strand	strand	NNP
10_1101-2021_01_08_423993	279	11	E	E	NNS
10_1101-2021_01_08_423993	279	12	(	(	-LRB-
10_1101-2021_01_08_423993	279	13	residues	residues	NNP
10_1101-2021_01_08_423993	279	14	268–270	268–270	CD
10_1101-2021_01_08_423993	279	15	)	)	-RRB-
10_1101-2021_01_08_423993	279	16	and	and	CC
10_1101-2021_01_08_423993	279	17	α	α	IN
10_1101-2021_01_08_423993	279	18	-	-	HYPH
10_1101-2021_01_08_423993	279	19	helix	helix	NN
10_1101-2021_01_08_423993	279	20	E	E	NNS
10_1101-2021_01_08_423993	279	21	(	(	-LRB-
10_1101-2021_01_08_423993	279	22	residues	residue	NNS
10_1101-2021_01_08_423993	279	23	261–267	261–267	CD
10_1101-2021_01_08_423993	279	24	)	)	-RRB-
10_1101-2021_01_08_423993	279	25	;	;	:
10_1101-2021_01_08_423993	279	26	both	both	DT
10_1101-2021_01_08_423993	279	27	located	locate	VBN
10_1101-2021_01_08_423993	279	28	near	near	IN
10_1101-2021_01_08_423993	279	29	the	the	DT
10_1101-2021_01_08_423993	279	30	zinc	zinc	NN
10_1101-2021_01_08_423993	279	31	finger	finger	NN
10_1101-2021_01_08_423993	279	32	motif	motif	NN
10_1101-2021_01_08_423993	279	33	in	in	IN
10_1101-2021_01_08_423993	279	34	the	the	DT
10_1101-2021_01_08_423993	279	35	β	β	NNP
10_1101-2021_01_08_423993	279	36	-	-	HYPH
10_1101-2021_01_08_423993	279	37	CASP	CASP	NNP
10_1101-2021_01_08_423993	279	38	domain	domain	NN
10_1101-2021_01_08_423993	279	39	(	(	-LRB-
10_1101-2021_01_08_423993	279	40	Figure	Figure	NNP
10_1101-2021_01_08_423993	279	41	8A	8A	NNP
10_1101-2021_01_08_423993	279	42	)	)	-RRB-
10_1101-2021_01_08_423993	279	43	.	.	.
10_1101-2021_01_08_423993	280	1	In	in	IN
10_1101-2021_01_08_423993	280	2	H33A	H33A	NNP
10_1101-2021_01_08_423993	280	3	and	and	CC
10_1101-2021_01_08_423993	280	4	H35D	H35D	NNP
10_1101-2021_01_08_423993	280	5	variants	variant	NNS
10_1101-2021_01_08_423993	280	6	,	,	,
10_1101-2021_01_08_423993	280	7	both	both	CC
10_1101-2021_01_08_423993	280	8	β	β	NNP
10_1101-2021_01_08_423993	280	9	-	-	HYPH
10_1101-2021_01_08_423993	280	10	strand	strand	NNP
10_1101-2021_01_08_423993	280	11	E	E	NNP
10_1101-2021_01_08_423993	280	12	and	and	CC
10_1101-2021_01_08_423993	280	13	α	α	CD
10_1101-2021_01_08_423993	280	14	-	-	HYPH
10_1101-2021_01_08_423993	280	15	helix	helix	NN
10_1101-2021_01_08_423993	280	16	E	E	NNS
10_1101-2021_01_08_423993	280	17	shifted	shift	VBD
10_1101-2021_01_08_423993	280	18	upward	upward	RB
10_1101-2021_01_08_423993	280	19	and	and	CC
10_1101-2021_01_08_423993	280	20	away	away	RB
10_1101-2021_01_08_423993	280	21	from	from	IN
10_1101-2021_01_08_423993	280	22	the	the	DT
10_1101-2021_01_08_423993	280	23	zinc	zinc	NN
10_1101-2021_01_08_423993	280	24	finger	finger	NN
10_1101-2021_01_08_423993	280	25	like	like	IN
10_1101-2021_01_08_423993	280	26	motif	motif	NN
10_1101-2021_01_08_423993	280	27	.	.	.
10_1101-2021_01_08_423993	281	1	These	these	DT
10_1101-2021_01_08_423993	281	2	conformational	conformational	JJ
10_1101-2021_01_08_423993	281	3	changes	change	NNS
10_1101-2021_01_08_423993	281	4	may	may	MD
10_1101-2021_01_08_423993	281	5	suggest	suggest	VB
10_1101-2021_01_08_423993	281	6	some	some	DT
10_1101-2021_01_08_423993	281	7	allosteric	allosteric	JJ
10_1101-2021_01_08_423993	281	8	regulation	regulation	NN
10_1101-2021_01_08_423993	281	9	in	in	IN
10_1101-2021_01_08_423993	281	10	terms	term	NNS
10_1101-2021_01_08_423993	281	11	of	of	IN
10_1101-2021_01_08_423993	281	12	substrate	substrate	NN
10_1101-2021_01_08_423993	281	13	binding	binding	NN
10_1101-2021_01_08_423993	281	14	and	and	CC
10_1101-2021_01_08_423993	281	15	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	281	16	activity	activity	NN
10_1101-2021_01_08_423993	281	17	of	of	IN
10_1101-2021_01_08_423993	281	18	the	the	DT
10_1101-2021_01_08_423993	281	19	enzyme	enzyme	NNS
10_1101-2021_01_08_423993	281	20	.	.	.
10_1101-2021_01_08_423993	282	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	282	2	also	also	RB
10_1101-2021_01_08_423993	282	3	tested	test	VBD
10_1101-2021_01_08_423993	282	4	the	the	DT
10_1101-2021_01_08_423993	282	5	activity	activity	NN
10_1101-2021_01_08_423993	282	6	of	of	IN
10_1101-2021_01_08_423993	282	7	the	the	DT
10_1101-2021_01_08_423993	282	8	D37A	D37A	NNP
10_1101-2021_01_08_423993	282	9	,	,	,
10_1101-2021_01_08_423993	282	10	H33A	H33A	NNP
10_1101-2021_01_08_423993	282	11	,	,	,
10_1101-2021_01_08_423993	282	12	and	and	CC
10_1101-2021_01_08_423993	282	13	H35D	H35D	NNP
10_1101-2021_01_08_423993	282	14	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	282	15	variants	variant	NNS
10_1101-2021_01_08_423993	282	16	in	in	IN
10_1101-2021_01_08_423993	282	17	vitro	vitro	FW
10_1101-2021_01_08_423993	282	18	using	use	VBG
10_1101-2021_01_08_423993	282	19	single	single	RB
10_1101-2021_01_08_423993	282	20	-	-	HYPH
10_1101-2021_01_08_423993	282	21	stranded	strand	VBN
10_1101-2021_01_08_423993	282	22	3	3	CD
10_1101-2021_01_08_423993	282	23	’	'	''
10_1101-2021_01_08_423993	282	24	end	end	NN
10_1101-2021_01_08_423993	282	25	radiolabelled	radiolabelle	VBN
10_1101-2021_01_08_423993	282	26	DNA	dna	NN
10_1101-2021_01_08_423993	282	27	as	as	IN
10_1101-2021_01_08_423993	282	28	a	a	DT
10_1101-2021_01_08_423993	282	29	substrate	substrate	NN
10_1101-2021_01_08_423993	282	30	in	in	IN
10_1101-2021_01_08_423993	282	31	a	a	DT
10_1101-2021_01_08_423993	282	32	gel	gel	NN
10_1101-2021_01_08_423993	282	33	-	-	HYPH
10_1101-2021_01_08_423993	282	34	based	base	VBN
10_1101-2021_01_08_423993	282	35	assay	assay	NN
10_1101-2021_01_08_423993	282	36	.	.	.
10_1101-2021_01_08_423993	283	1	All	all	DT
10_1101-2021_01_08_423993	283	2	three	three	CD
10_1101-2021_01_08_423993	283	3	variants	variant	NNS
10_1101-2021_01_08_423993	283	4	lost	lose	VBD
10_1101-2021_01_08_423993	283	5	their	-PRON-	PRP$
10_1101-2021_01_08_423993	283	6	ability	ability	NN
10_1101-2021_01_08_423993	283	7	to	to	TO
10_1101-2021_01_08_423993	283	8	digest	digest	VB
10_1101-2021_01_08_423993	283	9	the	the	DT
10_1101-2021_01_08_423993	283	10	DNA	DNA	NNP
10_1101-2021_01_08_423993	283	11	substrate	substrate	NN
10_1101-2021_01_08_423993	283	12	in	in	IN
10_1101-2021_01_08_423993	283	13	vitro	vitro	FW
10_1101-2021_01_08_423993	283	14	(	(	-LRB-
10_1101-2021_01_08_423993	283	15	Figure	Figure	NNP
10_1101-2021_01_08_423993	283	16	9	9	CD
10_1101-2021_01_08_423993	283	17	)	)	-RRB-
10_1101-2021_01_08_423993	283	18	.	.	.
10_1101-2021_01_08_423993	284	1	These	these	DT
10_1101-2021_01_08_423993	284	2	observations	observation	NNS
10_1101-2021_01_08_423993	284	3	are	be	VBP
10_1101-2021_01_08_423993	284	4	in	in	IN
10_1101-2021_01_08_423993	284	5	agreement	agreement	NN
10_1101-2021_01_08_423993	284	6	with	with	IN
10_1101-2021_01_08_423993	284	7	the	the	DT
10_1101-2021_01_08_423993	284	8	results	result	NNS
10_1101-2021_01_08_423993	284	9	obtained	obtain	VBN
10_1101-2021_01_08_423993	284	10	with	with	IN
10_1101-2021_01_08_423993	284	11	full	full	JJ
10_1101-2021_01_08_423993	284	12	-	-	HYPH
10_1101-2021_01_08_423993	284	13	length	length	NN
10_1101-2021_01_08_423993	284	14	variants	variant	NNS
10_1101-2021_01_08_423993	284	15	by	by	IN
10_1101-2021_01_08_423993	284	16	Ege	Ege	NNP
10_1101-2021_01_08_423993	284	17	et	et	NNP
10_1101-2021_01_08_423993	284	18	al	al	NNP
10_1101-2021_01_08_423993	284	19	.	.	.
10_1101-2021_01_08_423993	285	1	and	and	CC
10_1101-2021_01_08_423993	285	2	Pannicke	Pannicke	NNP
10_1101-2021_01_08_423993	285	3	et	et	NNP
10_1101-2021_01_08_423993	285	4	al	al	NNP
10_1101-2021_01_08_423993	285	5	.	.	.
10_1101-2021_01_08_423993	286	1	[	[	-LRB-
10_1101-2021_01_08_423993	286	2	27,31	27,31	CD
10_1101-2021_01_08_423993	286	3	]	]	-RRB-
10_1101-2021_01_08_423993	286	4	.	.	.
10_1101-2021_01_08_423993	287	1	Their	-PRON-	PRP$
10_1101-2021_01_08_423993	287	2	studies	study	NNS
10_1101-2021_01_08_423993	287	3	show	show	VBP
10_1101-2021_01_08_423993	287	4	that	that	IN
10_1101-2021_01_08_423993	287	5	the	the	DT
10_1101-2021_01_08_423993	287	6	full	full	JJ
10_1101-2021_01_08_423993	287	7	-	-	HYPH
10_1101-2021_01_08_423993	287	8	length	length	NN
10_1101-2021_01_08_423993	287	9	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	287	10	variants	variant	VBZ
10_1101-2021_01_08_423993	287	11	H33A	H33A	NNP
10_1101-2021_01_08_423993	287	12	,	,	,
10_1101-2021_01_08_423993	287	13	H35D	H35D	NNP
10_1101-2021_01_08_423993	287	14	,	,	,
10_1101-2021_01_08_423993	287	15	and	and	CC
10_1101-2021_01_08_423993	287	16	D37N	D37N	NNP
10_1101-2021_01_08_423993	287	17	are	be	VBP
10_1101-2021_01_08_423993	287	18	able	able	JJ
10_1101-2021_01_08_423993	287	19	to	to	TO
10_1101-2021_01_08_423993	287	20	interact	interact	VB
10_1101-2021_01_08_423993	287	21	with	with	IN
10_1101-2021_01_08_423993	287	22	and	and	CC
10_1101-2021_01_08_423993	287	23	be	be	VB
10_1101-2021_01_08_423993	287	24	phosphorylated	phosphorylate	VBN
10_1101-2021_01_08_423993	287	25	by	by	IN
10_1101-2021_01_08_423993	287	26	DNA	dna	NN
10_1101-2021_01_08_423993	287	27	-	-	HYPH
10_1101-2021_01_08_423993	287	28	PKcs	PKcs	NNP
10_1101-2021_01_08_423993	287	29	,	,	,
10_1101-2021_01_08_423993	287	30	however	however	RB
10_1101-2021_01_08_423993	287	31	,	,	,
10_1101-2021_01_08_423993	287	32	have	have	VBP
10_1101-2021_01_08_423993	287	33	lost	lose	VBN
10_1101-2021_01_08_423993	287	34	the	the	DT
10_1101-2021_01_08_423993	287	35	ability	ability	NN
10_1101-2021_01_08_423993	287	36	to	to	TO
10_1101-2021_01_08_423993	287	37	digest	digest	VB
10_1101-2021_01_08_423993	287	38	DNA	dna	NN
10_1101-2021_01_08_423993	287	39	substrates	substrate	NNS
10_1101-2021_01_08_423993	287	40	in	in	IN
10_1101-2021_01_08_423993	287	41	vitro	vitro	FW
10_1101-2021_01_08_423993	287	42	.	.	.
10_1101-2021_01_08_423993	288	1	The	the	DT
10_1101-2021_01_08_423993	288	2	combined	combine	VBN
10_1101-2021_01_08_423993	288	3	results	result	NNS
10_1101-2021_01_08_423993	288	4	reveal	reveal	VBP
10_1101-2021_01_08_423993	288	5	the	the	DT
10_1101-2021_01_08_423993	288	6	importance	importance	NN
10_1101-2021_01_08_423993	288	7	of	of	IN
10_1101-2021_01_08_423993	288	8	the	the	DT
10_1101-2021_01_08_423993	288	9	HxHxDH	hxhxdh	JJ
10_1101-2021_01_08_423993	288	10	motif	motif	NN
10_1101-2021_01_08_423993	288	11	and	and	CC
10_1101-2021_01_08_423993	288	12	highlight	highlight	VBP
10_1101-2021_01_08_423993	288	13	the	the	DT
10_1101-2021_01_08_423993	288	14	importance	importance	NN
10_1101-2021_01_08_423993	288	15	of	of	IN
10_1101-2021_01_08_423993	288	16	the	the	DT
10_1101-2021_01_08_423993	288	17	di	di	JJ
10_1101-2021_01_08_423993	288	18	-	-	HYPH
10_1101-2021_01_08_423993	288	19	metal	metal	JJ
10_1101-2021_01_08_423993	288	20	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	288	21	core	core	NN
10_1101-2021_01_08_423993	288	22	in	in	IN
10_1101-2021_01_08_423993	288	23	the	the	DT
10_1101-2021_01_08_423993	288	24	SNM1	SNM1	NNP
10_1101-2021_01_08_423993	288	25	family	family	NN
10_1101-2021_01_08_423993	288	26	,	,	,
10_1101-2021_01_08_423993	288	27	not	not	RB
10_1101-2021_01_08_423993	288	28	only	only	RB
10_1101-2021_01_08_423993	288	29	in	in	IN
10_1101-2021_01_08_423993	288	30	directly	directly	RB
10_1101-2021_01_08_423993	288	31	catalysing	catalyse	VBG
10_1101-2021_01_08_423993	288	32	hydrolysis	hydrolysis	NN
10_1101-2021_01_08_423993	288	33	,	,	,
10_1101-2021_01_08_423993	288	34	but	but	CC
10_1101-2021_01_08_423993	288	35	also	also	RB
10_1101-2021_01_08_423993	288	36	likely	likely	RB
10_1101-2021_01_08_423993	288	37	in	in	IN
10_1101-2021_01_08_423993	288	38	conformational	conformational	JJ
10_1101-2021_01_08_423993	288	39	changes	change	NNS
10_1101-2021_01_08_423993	288	40	involved	involve	VBN
10_1101-2021_01_08_423993	288	41	in	in	IN
10_1101-2021_01_08_423993	288	42	catalysis	catalysis	NN
10_1101-2021_01_08_423993	288	43	[	[	-LRB-
10_1101-2021_01_08_423993	288	44	43	43	CD
10_1101-2021_01_08_423993	288	45	]	]	-RRB-
10_1101-2021_01_08_423993	288	46	.	.	.
10_1101-2021_01_08_423993	289	1	Identification	identification	NN
10_1101-2021_01_08_423993	289	2	of	of	IN
10_1101-2021_01_08_423993	289	3	small	small	JJ
10_1101-2021_01_08_423993	289	4	molecule	molecule	JJ
10_1101-2021_01_08_423993	289	5	inhibitors	inhibitor	NNS
10_1101-2021_01_08_423993	289	6	of	of	IN
10_1101-2021_01_08_423993	289	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	289	8	Radiotherapy	Radiotherapy	NNP
10_1101-2021_01_08_423993	289	9	is	be	VBZ
10_1101-2021_01_08_423993	289	10	a	a	DT
10_1101-2021_01_08_423993	289	11	mainstay	mainstay	NN
10_1101-2021_01_08_423993	289	12	of	of	IN
10_1101-2021_01_08_423993	289	13	cancer	cancer	NN
10_1101-2021_01_08_423993	289	14	therapy	therapy	NN
10_1101-2021_01_08_423993	289	15	;	;	:
10_1101-2021_01_08_423993	289	16	its	-PRON-	PRP$
10_1101-2021_01_08_423993	289	17	effectiveness	effectiveness	NN
10_1101-2021_01_08_423993	289	18	relies	rely	VBZ
10_1101-2021_01_08_423993	289	19	on	on	IN
10_1101-2021_01_08_423993	289	20	inducing	induce	VBG
10_1101-2021_01_08_423993	289	21	DNA	dna	NN
10_1101-2021_01_08_423993	289	22	double	double	JJ
10_1101-2021_01_08_423993	289	23	-	-	HYPH
10_1101-2021_01_08_423993	289	24	strand	strand	NN
10_1101-2021_01_08_423993	289	25	breaks	break	NNS
10_1101-2021_01_08_423993	289	26	(	(	-LRB-
10_1101-2021_01_08_423993	289	27	DSBs	DSBs	NNP
10_1101-2021_01_08_423993	289	28	)	)	-RRB-
10_1101-2021_01_08_423993	289	29	that	that	WDT
10_1101-2021_01_08_423993	289	30	contain	contain	VBP
10_1101-2021_01_08_423993	289	31	complex	complex	NN
10_1101-2021_01_08_423993	289	32	,	,	,
10_1101-2021_01_08_423993	289	33	chemically	chemically	RB
10_1101-2021_01_08_423993	289	34	modified	modify	VBN
10_1101-2021_01_08_423993	289	35	ends	end	NNS
10_1101-2021_01_08_423993	289	36	that	that	WDT
10_1101-2021_01_08_423993	289	37	must	must	MD
10_1101-2021_01_08_423993	289	38	be	be	VB
10_1101-2021_01_08_423993	289	39	processed	process	VBN
10_1101-2021_01_08_423993	289	40	prior	prior	RB
10_1101-2021_01_08_423993	289	41	to	to	IN
10_1101-2021_01_08_423993	289	42	repair	repair	VB
10_1101-2021_01_08_423993	289	43	[	[	-LRB-
10_1101-2021_01_08_423993	289	44	62,63	62,63	CD
10_1101-2021_01_08_423993	289	45	]	]	-RRB-
10_1101-2021_01_08_423993	289	46	.	.	.
10_1101-2021_01_08_423993	290	1	The	the	DT
10_1101-2021_01_08_423993	290	2	canonical	canonical	JJ
10_1101-2021_01_08_423993	290	3	non	non	JJ
10_1101-2021_01_08_423993	290	4	-	-	JJ
10_1101-2021_01_08_423993	290	5	homologous	homologous	JJ
10_1101-2021_01_08_423993	290	6	end	end	NN
10_1101-2021_01_08_423993	290	7	-	-	HYPH
10_1101-2021_01_08_423993	290	8	joining	joining	NN
10_1101-2021_01_08_423993	290	9	(	(	-LRB-
10_1101-2021_01_08_423993	290	10	c	c	NNP
10_1101-2021_01_08_423993	290	11	-	-	:
10_1101-2021_01_08_423993	290	12	NHEJ	NHEJ	NNP
10_1101-2021_01_08_423993	290	13	)	)	-RRB-
10_1101-2021_01_08_423993	290	14	pathway	pathway	JJ
10_1101-2021_01_08_423993	290	15	repairs	repair	NNS
10_1101-2021_01_08_423993	290	16	80	80	NN
10_1101-2021_01_08_423993	290	17	%	%	NN
10_1101-2021_01_08_423993	290	18	of	of	IN
10_1101-2021_01_08_423993	290	19	DNA	DNA	NNP
10_1101-2021_01_08_423993	290	20	double	double	JJ
10_1101-2021_01_08_423993	290	21	-	-	HYPH
10_1101-2021_01_08_423993	290	22	strand	strand	NN
10_1101-2021_01_08_423993	290	23	breaks	break	NNS
10_1101-2021_01_08_423993	290	24	in	in	IN
10_1101-2021_01_08_423993	290	25	mammalian	mammalian	JJ
10_1101-2021_01_08_423993	290	26	cells	cell	NNS
10_1101-2021_01_08_423993	290	27	[	[	-LRB-
10_1101-2021_01_08_423993	290	28	20,23	20,23	CD
10_1101-2021_01_08_423993	290	29	]	]	-RRB-
10_1101-2021_01_08_423993	290	30	.	.	.
10_1101-2021_01_08_423993	291	1	Therefore	therefore	RB
10_1101-2021_01_08_423993	291	2	,	,	,
10_1101-2021_01_08_423993	291	3	combining	combine	VBG
10_1101-2021_01_08_423993	291	4	radiation	radiation	NN
10_1101-2021_01_08_423993	291	5	therapy	therapy	NN
10_1101-2021_01_08_423993	291	6	in	in	IN
10_1101-2021_01_08_423993	291	7	conjunction	conjunction	NN
10_1101-2021_01_08_423993	291	8	with	with	IN
10_1101-2021_01_08_423993	291	9	c	c	NNP
10_1101-2021_01_08_423993	291	10	-	-	HYPH
10_1101-2021_01_08_423993	291	11	NHEJ	NHEJ	NNP
10_1101-2021_01_08_423993	291	12	inhibitors	inhibitor	NNS
10_1101-2021_01_08_423993	291	13	could	could	MD
10_1101-2021_01_08_423993	291	14	selectively	selectively	RB
10_1101-2021_01_08_423993	291	15	radiosensitise	radiosensitise	VB
10_1101-2021_01_08_423993	291	16	tumours	tumour	NNS
10_1101-2021_01_08_423993	291	17	.	.	.
10_1101-2021_01_08_423993	292	1	Weterings	Weterings	NNP
10_1101-2021_01_08_423993	292	2	et	et	FW
10_1101-2021_01_08_423993	292	3	al	al	NNP
10_1101-2021_01_08_423993	292	4	.	.	.
10_1101-2021_01_08_423993	293	1	have	have	VBP
10_1101-2021_01_08_423993	293	2	reported	report	VBN
10_1101-2021_01_08_423993	293	3	a	a	DT
10_1101-2021_01_08_423993	293	4	compound	compound	NN
10_1101-2021_01_08_423993	293	5	that	that	WDT
10_1101-2021_01_08_423993	293	6	interferes	interfere	VBZ
10_1101-2021_01_08_423993	293	7	with	with	IN
10_1101-2021_01_08_423993	293	8	the	the	DT
10_1101-2021_01_08_423993	293	9	binding	binding	NN
10_1101-2021_01_08_423993	293	10	of	of	IN
10_1101-2021_01_08_423993	293	11	Ku70/80	Ku70/80	NNS
10_1101-2021_01_08_423993	293	12	to	to	IN
10_1101-2021_01_08_423993	293	13	DNA	dna	NN
10_1101-2021_01_08_423993	293	14	,	,	,
10_1101-2021_01_08_423993	293	15	thereby	thereby	RB
10_1101-2021_01_08_423993	293	16	increasing	increase	VBG
10_1101-2021_01_08_423993	293	17	sensitivity	sensitivity	NN
10_1101-2021_01_08_423993	293	18	to	to	IN
10_1101-2021_01_08_423993	293	19	ionising	ionise	VBG
10_1101-2021_01_08_423993	293	20	radiation	radiation	NN
10_1101-2021_01_08_423993	293	21	in	in	IN
10_1101-2021_01_08_423993	293	22	human	human	JJ
10_1101-2021_01_08_423993	293	23	cell	cell	NN
10_1101-2021_01_08_423993	293	24	lines	line	NNS
10_1101-2021_01_08_423993	293	25	[	[	-LRB-
10_1101-2021_01_08_423993	293	26	64	64	CD
10_1101-2021_01_08_423993	293	27	]	]	-RRB-
10_1101-2021_01_08_423993	293	28	;	;	:
10_1101-2021_01_08_423993	293	29	ATM	ATM	NNS
10_1101-2021_01_08_423993	293	30	inhibitors	inhibitor	NNS
10_1101-2021_01_08_423993	293	31	are	be	VBP
10_1101-2021_01_08_423993	293	32	also	also	RB
10_1101-2021_01_08_423993	293	33	in	in	IN
10_1101-2021_01_08_423993	293	34	advanced	advanced	JJ
10_1101-2021_01_08_423993	293	35	clinical	clinical	JJ
10_1101-2021_01_08_423993	293	36	development	development	NN
10_1101-2021_01_08_423993	293	37	and	and	CC
10_1101-2021_01_08_423993	293	38	represent	represent	VB
10_1101-2021_01_08_423993	293	39	the	the	DT
10_1101-2021_01_08_423993	293	40	most	most	RBS
10_1101-2021_01_08_423993	293	41	developed	developed	JJ
10_1101-2021_01_08_423993	293	42	strategy	strategy	NN
10_1101-2021_01_08_423993	293	43	to	to	TO
10_1101-2021_01_08_423993	293	44	inhibit	inhibit	VB
10_1101-2021_01_08_423993	293	45	DSB	DSB	NNP
10_1101-2021_01_08_423993	293	46	repair	repair	NN
10_1101-2021_01_08_423993	293	47	to	to	TO
10_1101-2021_01_08_423993	293	48	increase	increase	VB
10_1101-2021_01_08_423993	293	49	the	the	DT
10_1101-2021_01_08_423993	293	50	efficacy	efficacy	NN
10_1101-2021_01_08_423993	293	51	of	of	IN
10_1101-2021_01_08_423993	293	52	radiotherapy	radiotherapy	NN
10_1101-2021_01_08_423993	293	53	[	[	-LRB-
10_1101-2021_01_08_423993	293	54	65	65	CD
10_1101-2021_01_08_423993	293	55	]	]	-RRB-
10_1101-2021_01_08_423993	293	56	.CC	.CC	:
10_1101-2021_01_08_423993	293	57	-	-	:
10_1101-2021_01_08_423993	293	58	BY	by	IN
10_1101-2021_01_08_423993	293	59	4.0	4.0	CD
10_1101-2021_01_08_423993	293	60	International	international	JJ
10_1101-2021_01_08_423993	293	61	licensemade	licensemade	NN
10_1101-2021_01_08_423993	293	62	available	available	JJ
10_1101-2021_01_08_423993	293	63	under	under	IN
10_1101-2021_01_08_423993	293	64	a	a	DT
10_1101-2021_01_08_423993	293	65	(	(	-LRB-
10_1101-2021_01_08_423993	293	66	which	which	WDT
10_1101-2021_01_08_423993	293	67	was	be	VBD
10_1101-2021_01_08_423993	293	68	not	not	RB
10_1101-2021_01_08_423993	293	69	certified	certify	VBN
10_1101-2021_01_08_423993	293	70	by	by	IN
10_1101-2021_01_08_423993	293	71	peer	peer	NN
10_1101-2021_01_08_423993	293	72	review	review	NN
10_1101-2021_01_08_423993	293	73	)	)	-RRB-
10_1101-2021_01_08_423993	293	74	is	be	VBZ
10_1101-2021_01_08_423993	293	75	the	the	DT
10_1101-2021_01_08_423993	293	76	author	author	NN
10_1101-2021_01_08_423993	293	77	/	/	SYM
10_1101-2021_01_08_423993	293	78	funder	funder	NN
10_1101-2021_01_08_423993	293	79	,	,	,
10_1101-2021_01_08_423993	293	80	who	who	WP
10_1101-2021_01_08_423993	293	81	has	have	VBZ
10_1101-2021_01_08_423993	293	82	granted	grant	VBN
10_1101-2021_01_08_423993	293	83	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	293	84	a	a	DT
10_1101-2021_01_08_423993	293	85	license	license	NN
10_1101-2021_01_08_423993	293	86	to	to	TO
10_1101-2021_01_08_423993	293	87	display	display	VB
10_1101-2021_01_08_423993	293	88	the	the	DT
10_1101-2021_01_08_423993	293	89	preprint	preprint	NN
10_1101-2021_01_08_423993	293	90	in	in	IN
10_1101-2021_01_08_423993	293	91	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	293	92	.	.	.
10_1101-2021_01_08_423993	294	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	294	2	is	be	VBZ
10_1101-2021_01_08_423993	294	3	The	the	DT
10_1101-2021_01_08_423993	294	4	copyright	copyright	NN
10_1101-2021_01_08_423993	294	5	holder	holder	NN
10_1101-2021_01_08_423993	294	6	for	for	IN
10_1101-2021_01_08_423993	294	7	this	this	DT
10_1101-2021_01_08_423993	294	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	294	9	version	version	NN
10_1101-2021_01_08_423993	294	10	posted	post	VBD
10_1101-2021_01_08_423993	294	11	January	January	NNP
10_1101-2021_01_08_423993	294	12	8	8	CD
10_1101-2021_01_08_423993	294	13	,	,	,
10_1101-2021_01_08_423993	294	14	2021	2021	CD
10_1101-2021_01_08_423993	294	15	.	.	.
10_1101-2021_01_08_423993	294	16	;	;	:
10_1101-2021_01_08_423993	294	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	294	18	:	:	:
10_1101-2021_01_08_423993	294	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	294	20	preprint	preprint	NN
10_1101-2021_01_08_423993	294	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	294	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	294	23	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	294	24	,	,	,
10_1101-2021_01_08_423993	294	25	along	along	IN
10_1101-2021_01_08_423993	294	26	with	with	IN
10_1101-2021_01_08_423993	294	27	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	294	28	and	and	CC
10_1101-2021_01_08_423993	294	29	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	294	30	,	,	,
10_1101-2021_01_08_423993	294	31	possess	possess	VBP
10_1101-2021_01_08_423993	294	32	a	a	DT
10_1101-2021_01_08_423993	294	33	conserved	conserve	VBN
10_1101-2021_01_08_423993	294	34	MBL	mbl	NN
10_1101-2021_01_08_423993	294	35	-	-	HYPH
10_1101-2021_01_08_423993	294	36	fold	fold	VB
10_1101-2021_01_08_423993	294	37	domain	domain	NN
10_1101-2021_01_08_423993	294	38	that	that	WDT
10_1101-2021_01_08_423993	294	39	is	be	VBZ
10_1101-2021_01_08_423993	294	40	similar	similar	JJ
10_1101-2021_01_08_423993	294	41	to	to	IN
10_1101-2021_01_08_423993	294	42	the	the	DT
10_1101-2021_01_08_423993	294	43	true	true	JJ
10_1101-2021_01_08_423993	294	44	bacterial	bacterial	JJ
10_1101-2021_01_08_423993	294	45	MBLs	mbl	NNS
10_1101-2021_01_08_423993	294	46	.	.	.
10_1101-2021_01_08_423993	295	1	Previous	previous	JJ
10_1101-2021_01_08_423993	295	2	studies	study	NNS
10_1101-2021_01_08_423993	295	3	on	on	IN
10_1101-2021_01_08_423993	295	4	human	human	JJ
10_1101-2021_01_08_423993	295	5	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	295	6	and	and	CC
10_1101-2021_01_08_423993	295	7	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	295	8	/	/	SYM
10_1101-2021_01_08_423993	295	9	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	295	10	,	,	,
10_1101-2021_01_08_423993	295	11	showed	show	VBD
10_1101-2021_01_08_423993	295	12	that	that	IN
10_1101-2021_01_08_423993	295	13	ceftriaxone	ceftriaxone	NN
10_1101-2021_01_08_423993	295	14	(	(	-LRB-
10_1101-2021_01_08_423993	295	15	Rocephin	Rocephin	NNP
10_1101-2021_01_08_423993	295	16	)	)	-RRB-
10_1101-2021_01_08_423993	295	17	,	,	,
10_1101-2021_01_08_423993	295	18	a	a	DT
10_1101-2021_01_08_423993	295	19	widely	widely	RB
10_1101-2021_01_08_423993	295	20	used	use	VBN
10_1101-2021_01_08_423993	295	21	β	β	NNP
10_1101-2021_01_08_423993	295	22	-	-	HYPH
10_1101-2021_01_08_423993	295	23	lactam	lactam	NNP
10_1101-2021_01_08_423993	295	24	antibacterial	antibacterial	NNP
10_1101-2021_01_08_423993	295	25	(	(	-LRB-
10_1101-2021_01_08_423993	295	26	third	third	JJ
10_1101-2021_01_08_423993	295	27	generation	generation	NN
10_1101-2021_01_08_423993	295	28	cephalosporin	cephalosporin	NNP
10_1101-2021_01_08_423993	295	29	)	)	-RRB-
10_1101-2021_01_08_423993	295	30	inhibits	inhibit	VBZ
10_1101-2021_01_08_423993	295	31	the	the	DT
10_1101-2021_01_08_423993	295	32	nuclease	nuclease	NNP
10_1101-2021_01_08_423993	295	33	activity	activity	NN
10_1101-2021_01_08_423993	295	34	of	of	IN
10_1101-2021_01_08_423993	295	35	both	both	DT
10_1101-2021_01_08_423993	295	36	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	295	37	and	and	CC
10_1101-2021_01_08_423993	295	38	SNM1B	snm1b	DT
10_1101-2021_01_08_423993	295	39	[	[	-LRB-
10_1101-2021_01_08_423993	295	40	66	66	CD
10_1101-2021_01_08_423993	295	41	]	]	-RRB-
10_1101-2021_01_08_423993	295	42	.	.	.
10_1101-2021_01_08_423993	296	1	To	to	TO
10_1101-2021_01_08_423993	296	2	investigate	investigate	VB
10_1101-2021_01_08_423993	296	3	if	if	IN
10_1101-2021_01_08_423993	296	4	this	this	DT
10_1101-2021_01_08_423993	296	5	class	class	NN
10_1101-2021_01_08_423993	296	6	of	of	IN
10_1101-2021_01_08_423993	296	7	β	β	NNP
10_1101-2021_01_08_423993	296	8	-	-	HYPH
10_1101-2021_01_08_423993	296	9	lactam	lactam	NNP
10_1101-2021_01_08_423993	296	10	anti	anti	JJ
10_1101-2021_01_08_423993	296	11	-	-	JJ
10_1101-2021_01_08_423993	296	12	bacterial	bacterial	JJ
10_1101-2021_01_08_423993	296	13	compounds	compound	NNS
10_1101-2021_01_08_423993	296	14	could	could	MD
10_1101-2021_01_08_423993	296	15	inhibit	inhibit	VB
10_1101-2021_01_08_423993	296	16	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	296	17	we	-PRON-	PRP
10_1101-2021_01_08_423993	296	18	performed	perform	VBD
10_1101-2021_01_08_423993	296	19	fluorescence	fluorescence	NN
10_1101-2021_01_08_423993	296	20	-	-	HYPH
10_1101-2021_01_08_423993	296	21	based	base	VBN
10_1101-2021_01_08_423993	296	22	nuclease	nuclease	NNP
10_1101-2021_01_08_423993	296	23	assays	assay	VBZ
10_1101-2021_01_08_423993	296	24	with	with	IN
10_1101-2021_01_08_423993	296	25	three	three	CD
10_1101-2021_01_08_423993	296	26	cephalosporins	cephalosporin	NNS
10_1101-2021_01_08_423993	296	27	,	,	,
10_1101-2021_01_08_423993	296	28	i.e.	i.e.	FW
10_1101-2021_01_08_423993	297	1	ceftriaxone	ceftriaxone	NN
10_1101-2021_01_08_423993	297	2	,	,	,
10_1101-2021_01_08_423993	297	3	cefotaxime	cefotaxime	NN
10_1101-2021_01_08_423993	297	4	and	and	CC
10_1101-2021_01_08_423993	297	5	7-aminocephalosporanic	7-aminocephalosporanic	CD
10_1101-2021_01_08_423993	297	6	acid	acid	NN
10_1101-2021_01_08_423993	297	7	(	(	-LRB-
10_1101-2021_01_08_423993	297	8	Figure	Figure	NNP
10_1101-2021_01_08_423993	297	9	10A	10A	NNP
10_1101-2021_01_08_423993	297	10	)	)	-RRB-
10_1101-2021_01_08_423993	297	11	.	.	.
10_1101-2021_01_08_423993	298	1	The	the	DT
10_1101-2021_01_08_423993	298	2	results	result	NNS
10_1101-2021_01_08_423993	298	3	show	show	VBP
10_1101-2021_01_08_423993	298	4	that	that	IN
10_1101-2021_01_08_423993	298	5	neither	neither	CC
10_1101-2021_01_08_423993	298	6	cefotaxime	cefotaxime	NN
10_1101-2021_01_08_423993	298	7	nor	nor	CC
10_1101-2021_01_08_423993	298	8	the	the	DT
10_1101-2021_01_08_423993	298	9	parent	parent	NN
10_1101-2021_01_08_423993	298	10	compound	compound	NN
10_1101-2021_01_08_423993	298	11	,	,	,
10_1101-2021_01_08_423993	298	12	7-aminocephalosporanic	7-aminocephalosporanic	CD
10_1101-2021_01_08_423993	298	13	acid	acid	NN
10_1101-2021_01_08_423993	298	14	,	,	,
10_1101-2021_01_08_423993	298	15	potently	potently	RB
10_1101-2021_01_08_423993	298	16	inhibit	inhibit	VB
10_1101-2021_01_08_423993	298	17	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	298	18	’	’	POS
10_1101-2021_01_08_423993	298	19	activity	activity	NN
10_1101-2021_01_08_423993	298	20	,	,	,
10_1101-2021_01_08_423993	298	21	whilst	whilst	IN
10_1101-2021_01_08_423993	298	22	ceftriaxone	ceftriaxone	NN
10_1101-2021_01_08_423993	298	23	inhibits	inhibit	NNS
10_1101-2021_01_08_423993	298	24	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	298	25	with	with	IN
10_1101-2021_01_08_423993	298	26	a	a	DT
10_1101-2021_01_08_423993	298	27	modest	modest	JJ
10_1101-2021_01_08_423993	298	28	IC50	IC50	NNP
10_1101-2021_01_08_423993	298	29	of	of	IN
10_1101-2021_01_08_423993	298	30	65	65	CD
10_1101-2021_01_08_423993	298	31	µM	µM	NNP
10_1101-2021_01_08_423993	298	32	(	(	-LRB-
10_1101-2021_01_08_423993	298	33	Figure	Figure	NNP
10_1101-2021_01_08_423993	298	34	10B	10B	NNP
10_1101-2021_01_08_423993	298	35	)	)	-RRB-
10_1101-2021_01_08_423993	298	36	.	.	.
10_1101-2021_01_08_423993	299	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	299	2	solved	solve	VBD
10_1101-2021_01_08_423993	299	3	the	the	DT
10_1101-2021_01_08_423993	299	4	structure	structure	NN
10_1101-2021_01_08_423993	299	5	of	of	IN
10_1101-2021_01_08_423993	299	6	ceftriaxone	ceftriaxone	NN
10_1101-2021_01_08_423993	299	7	bound	bind	VBN
10_1101-2021_01_08_423993	299	8	to	to	IN
10_1101-2021_01_08_423993	299	9	the	the	DT
10_1101-2021_01_08_423993	299	10	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	299	11	domain	domain	NN
10_1101-2021_01_08_423993	299	12	of	of	IN
10_1101-2021_01_08_423993	299	13	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	299	14	(	(	-LRB-
10_1101-2021_01_08_423993	299	15	purified	purify	VBN
10_1101-2021_01_08_423993	299	16	by	by	IN
10_1101-2021_01_08_423993	299	17	IMAC	IMAC	NNP
10_1101-2021_01_08_423993	299	18	)	)	-RRB-
10_1101-2021_01_08_423993	299	19	at	at	IN
10_1101-2021_01_08_423993	299	20	1.9	1.9	CD
10_1101-2021_01_08_423993	299	21	Å	å	NN
10_1101-2021_01_08_423993	299	22	resolution	resolution	NN
10_1101-2021_01_08_423993	299	23	(	(	-LRB-
10_1101-2021_01_08_423993	299	24	Figure	figure	NN
10_1101-2021_01_08_423993	299	25	10C	10c	CD
10_1101-2021_01_08_423993	299	26	)	)	-RRB-
10_1101-2021_01_08_423993	299	27	by	by	IN
10_1101-2021_01_08_423993	299	28	soaking	soak	VBG
10_1101-2021_01_08_423993	299	29	an	an	DT
10_1101-2021_01_08_423993	299	30	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	299	31	crystal	crystal	NN
10_1101-2021_01_08_423993	299	32	with	with	IN
10_1101-2021_01_08_423993	299	33	ceftriaxone	ceftriaxone	NN
10_1101-2021_01_08_423993	299	34	.	.	.
10_1101-2021_01_08_423993	300	1	This	this	DT
10_1101-2021_01_08_423993	300	2	structure	structure	NN
10_1101-2021_01_08_423993	300	3	was	be	VBD
10_1101-2021_01_08_423993	300	4	solved	solve	VBN
10_1101-2021_01_08_423993	300	5	by	by	IN
10_1101-2021_01_08_423993	300	6	molecular	molecular	JJ
10_1101-2021_01_08_423993	300	7	replacement	replacement	NN
10_1101-2021_01_08_423993	300	8	(	(	-LRB-
10_1101-2021_01_08_423993	300	9	using	use	VBG
10_1101-2021_01_08_423993	300	10	PDB	pdb	NN
10_1101-2021_01_08_423993	300	11	:	:	:
10_1101-2021_01_08_423993	300	12	6TT5	6tt5	XX
10_1101-2021_01_08_423993	300	13	as	as	IN
10_1101-2021_01_08_423993	300	14	a	a	DT
10_1101-2021_01_08_423993	300	15	model	model	NN
10_1101-2021_01_08_423993	300	16	)	)	-RRB-
10_1101-2021_01_08_423993	300	17	,	,	,
10_1101-2021_01_08_423993	300	18	in	in	IN
10_1101-2021_01_08_423993	300	19	the	the	DT
10_1101-2021_01_08_423993	300	20	space	space	NN
10_1101-2021_01_08_423993	300	21	group	group	NN
10_1101-2021_01_08_423993	300	22	P1	p1	NN
10_1101-2021_01_08_423993	300	23	with	with	IN
10_1101-2021_01_08_423993	300	24	one	one	CD
10_1101-2021_01_08_423993	300	25	protein	protein	NN
10_1101-2021_01_08_423993	300	26	molecule	molecule	NN
10_1101-2021_01_08_423993	300	27	in	in	IN
10_1101-2021_01_08_423993	300	28	the	the	DT
10_1101-2021_01_08_423993	300	29	asymmetric	asymmetric	JJ
10_1101-2021_01_08_423993	300	30	unit	unit	NN
10_1101-2021_01_08_423993	300	31	.	.	.
10_1101-2021_01_08_423993	301	1	As	as	IN
10_1101-2021_01_08_423993	301	2	before	before	RB
10_1101-2021_01_08_423993	301	3	,	,	,
10_1101-2021_01_08_423993	301	4	in	in	IN
10_1101-2021_01_08_423993	301	5	this	this	DT
10_1101-2021_01_08_423993	301	6	structure	structure	NN
10_1101-2021_01_08_423993	301	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	301	8	possesses	possess	VBZ
10_1101-2021_01_08_423993	301	9	the	the	DT
10_1101-2021_01_08_423993	301	10	canonical	canonical	JJ
10_1101-2021_01_08_423993	301	11	bilobar	bilobar	NN
10_1101-2021_01_08_423993	301	12	MBL	MBL	NNP
10_1101-2021_01_08_423993	301	13	and	and	CC
10_1101-2021_01_08_423993	301	14	β	β	NNP
10_1101-2021_01_08_423993	301	15	-	-	HYPH
10_1101-2021_01_08_423993	301	16	CASP	CASP	NNP
10_1101-2021_01_08_423993	301	17	fold	fold	VBP
10_1101-2021_01_08_423993	301	18	with	with	IN
10_1101-2021_01_08_423993	301	19	an	an	DT
10_1101-2021_01_08_423993	301	20	active	active	JJ
10_1101-2021_01_08_423993	301	21	site	site	NN
10_1101-2021_01_08_423993	301	22	containing	contain	VBG
10_1101-2021_01_08_423993	301	23	one	one	CD
10_1101-2021_01_08_423993	301	24	nickel	nickel	NN
10_1101-2021_01_08_423993	301	25	ion	ion	NN
10_1101-2021_01_08_423993	301	26	,	,	,
10_1101-2021_01_08_423993	301	27	possibly	possibly	RB
10_1101-2021_01_08_423993	301	28	related	relate	VBN
10_1101-2021_01_08_423993	301	29	to	to	IN
10_1101-2021_01_08_423993	301	30	the	the	DT
10_1101-2021_01_08_423993	301	31	purification	purification	NN
10_1101-2021_01_08_423993	301	32	method	method	NN
10_1101-2021_01_08_423993	301	33	.	.	.
10_1101-2021_01_08_423993	302	1	Ceftriaxone	ceftriaxone	JJ
10_1101-2021_01_08_423993	302	2	binds	bind	NNS
10_1101-2021_01_08_423993	302	3	to	to	IN
10_1101-2021_01_08_423993	302	4	the	the	DT
10_1101-2021_01_08_423993	302	5	protein	protein	NN
10_1101-2021_01_08_423993	302	6	surface	surface	NN
10_1101-2021_01_08_423993	302	7	in	in	IN
10_1101-2021_01_08_423993	302	8	an	an	DT
10_1101-2021_01_08_423993	302	9	extended	extended	JJ
10_1101-2021_01_08_423993	302	10	manner	manner	NN
10_1101-2021_01_08_423993	302	11	making	make	VBG
10_1101-2021_01_08_423993	302	12	interactions	interaction	NNS
10_1101-2021_01_08_423993	302	13	with	with	IN
10_1101-2021_01_08_423993	302	14	the	the	DT
10_1101-2021_01_08_423993	302	15	active	active	JJ
10_1101-2021_01_08_423993	302	16	site	site	NN
10_1101-2021_01_08_423993	302	17	,	,	,
10_1101-2021_01_08_423993	302	18	towards	towards	IN
10_1101-2021_01_08_423993	302	19	the	the	DT
10_1101-2021_01_08_423993	302	20	β	β	NNP
10_1101-2021_01_08_423993	302	21	-	-	HYPH
10_1101-2021_01_08_423993	302	22	CASP	CASP	NNP
10_1101-2021_01_08_423993	302	23	domain	domain	NN
10_1101-2021_01_08_423993	302	24	(	(	-LRB-
10_1101-2021_01_08_423993	302	25	Figure	figure	NN
10_1101-2021_01_08_423993	302	26	10	10	CD
10_1101-2021_01_08_423993	302	27	C	C	NNP
10_1101-2021_01_08_423993	302	28	)	)	-RRB-
10_1101-2021_01_08_423993	302	29	.	.	.
10_1101-2021_01_08_423993	303	1	There	there	EX
10_1101-2021_01_08_423993	303	2	is	be	VBZ
10_1101-2021_01_08_423993	303	3	no	no	DT
10_1101-2021_01_08_423993	303	4	evidence	evidence	NN
10_1101-2021_01_08_423993	303	5	for	for	IN
10_1101-2021_01_08_423993	303	6	cleavage	cleavage	NN
10_1101-2021_01_08_423993	303	7	of	of	IN
10_1101-2021_01_08_423993	303	8	the	the	DT
10_1101-2021_01_08_423993	303	9	β	β	NNP
10_1101-2021_01_08_423993	303	10	-	-	HYPH
10_1101-2021_01_08_423993	303	11	lactam	lactam	NNP
10_1101-2021_01_08_423993	303	12	ring	ring	NN
10_1101-2021_01_08_423993	303	13	nor	nor	CC
10_1101-2021_01_08_423993	303	14	of	of	IN
10_1101-2021_01_08_423993	303	15	loss	loss	NN
10_1101-2021_01_08_423993	303	16	of	of	IN
10_1101-2021_01_08_423993	303	17	the	the	DT
10_1101-2021_01_08_423993	303	18	C-3	C-3	NNP
10_1101-2021_01_08_423993	303	19	’	’	POS
10_1101-2021_01_08_423993	303	20	cephalosporin	cephalosporin	NN
10_1101-2021_01_08_423993	303	21	side	side	NN
10_1101-2021_01_08_423993	303	22	chain	chain	NN
10_1101-2021_01_08_423993	303	23	,	,	,
10_1101-2021_01_08_423993	303	24	reactions	reaction	NNS
10_1101-2021_01_08_423993	303	25	that	that	WDT
10_1101-2021_01_08_423993	303	26	can	can	MD
10_1101-2021_01_08_423993	303	27	occur	occur	VB
10_1101-2021_01_08_423993	303	28	during	during	IN
10_1101-2021_01_08_423993	303	29	‘	'	``
10_1101-2021_01_08_423993	303	30	true	true	JJ
10_1101-2021_01_08_423993	303	31	’	'	''
10_1101-2021_01_08_423993	303	32	MBL	MBL	NNP
10_1101-2021_01_08_423993	303	33	catalysed	catalyse	VBD
10_1101-2021_01_08_423993	303	34	cephalosporin	cephalosporin	NNP
10_1101-2021_01_08_423993	303	35	hydrolysis	hydrolysis	NN
10_1101-2021_01_08_423993	303	36	.	.	.
10_1101-2021_01_08_423993	304	1	The	the	DT
10_1101-2021_01_08_423993	304	2	electron	electron	NN
10_1101-2021_01_08_423993	304	3	density	density	NN
10_1101-2021_01_08_423993	304	4	at	at	IN
10_1101-2021_01_08_423993	304	5	the	the	DT
10_1101-2021_01_08_423993	304	6	active	active	JJ
10_1101-2021_01_08_423993	304	7	site	site	NN
10_1101-2021_01_08_423993	304	8	clearly	clearly	RB
10_1101-2021_01_08_423993	304	9	reveals	reveal	VBZ
10_1101-2021_01_08_423993	304	10	the	the	DT
10_1101-2021_01_08_423993	304	11	presence	presence	NN
10_1101-2021_01_08_423993	304	12	of	of	IN
10_1101-2021_01_08_423993	304	13	the	the	DT
10_1101-2021_01_08_423993	304	14	ceftriaxone	ceftriaxone	JJ
10_1101-2021_01_08_423993	304	15	side	side	NN
10_1101-2021_01_08_423993	304	16	chain	chain	NN
10_1101-2021_01_08_423993	304	17	in	in	IN
10_1101-2021_01_08_423993	304	18	a	a	DT
10_1101-2021_01_08_423993	304	19	position	position	NN
10_1101-2021_01_08_423993	304	20	to	to	TO
10_1101-2021_01_08_423993	304	21	coordinate	coordinate	VB
10_1101-2021_01_08_423993	304	22	the	the	DT
10_1101-2021_01_08_423993	304	23	nickel	nickel	NN
10_1101-2021_01_08_423993	304	24	ion	ion	NN
10_1101-2021_01_08_423993	304	25	(	(	-LRB-
10_1101-2021_01_08_423993	304	26	at	at	IN
10_1101-2021_01_08_423993	304	27	the	the	DT
10_1101-2021_01_08_423993	304	28	Zn1	zn1	NN
10_1101-2021_01_08_423993	304	29	site	site	NN
10_1101-2021_01_08_423993	304	30	)	)	-RRB-
10_1101-2021_01_08_423993	304	31	replacing	replace	VBG
10_1101-2021_01_08_423993	304	32	water	water	NN
10_1101-2021_01_08_423993	304	33	molecules	molecule	NNS
10_1101-2021_01_08_423993	304	34	(	(	-LRB-
10_1101-2021_01_08_423993	304	35	waters	water	NNS
10_1101-2021_01_08_423993	304	36	72	72	CD
10_1101-2021_01_08_423993	304	37	and	and	CC
10_1101-2021_01_08_423993	304	38	106	106	CD
10_1101-2021_01_08_423993	304	39	)	)	-RRB-
10_1101-2021_01_08_423993	304	40	compared	compare	VBN
10_1101-2021_01_08_423993	304	41	with	with	IN
10_1101-2021_01_08_423993	304	42	the	the	DT
10_1101-2021_01_08_423993	304	43	apo	apo	NNP
10_1101-2021_01_08_423993	304	44	structure	structure	NN
10_1101-2021_01_08_423993	304	45	(	(	-LRB-
10_1101-2021_01_08_423993	304	46	Figure	Figure	NNP
10_1101-2021_01_08_423993	304	47	10D	10D	NNP
10_1101-2021_01_08_423993	304	48	)	)	-RRB-
10_1101-2021_01_08_423993	304	49	.	.	.
10_1101-2021_01_08_423993	305	1	Despite	despite	IN
10_1101-2021_01_08_423993	305	2	the	the	DT
10_1101-2021_01_08_423993	305	3	conservation	conservation	NN
10_1101-2021_01_08_423993	305	4	of	of	IN
10_1101-2021_01_08_423993	305	5	key	key	JJ
10_1101-2021_01_08_423993	305	6	elements	element	NNS
10_1101-2021_01_08_423993	305	7	of	of	IN
10_1101-2021_01_08_423993	305	8	the	the	DT
10_1101-2021_01_08_423993	305	9	active	active	JJ
10_1101-2021_01_08_423993	305	10	site	site	NN
10_1101-2021_01_08_423993	305	11	of	of	IN
10_1101-2021_01_08_423993	305	12	the	the	DT
10_1101-2021_01_08_423993	305	13	MBL	MBL	NNP
10_1101-2021_01_08_423993	305	14	fold	fold	VB
10_1101-2021_01_08_423993	305	15	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	305	16	and	and	CC
10_1101-2021_01_08_423993	305	17	the	the	DT
10_1101-2021_01_08_423993	305	18	‘	'	``
10_1101-2021_01_08_423993	305	19	true	true	JJ
10_1101-2021_01_08_423993	305	20	’	'	''
10_1101-2021_01_08_423993	305	21	b	b	NNP
10_1101-2021_01_08_423993	305	22	-	-	HYPH
10_1101-2021_01_08_423993	305	23	lactam	lactam	NNP
10_1101-2021_01_08_423993	305	24	hydrolysing	hydrolyse	VBG
10_1101-2021_01_08_423993	305	25	MBLs	mbl	NNS
10_1101-2021_01_08_423993	305	26	[	[	-LRB-
10_1101-2021_01_08_423993	305	27	67	67	CD
10_1101-2021_01_08_423993	305	28	]	]	-RRB-
10_1101-2021_01_08_423993	305	29	,	,	,
10_1101-2021_01_08_423993	305	30	ceftriaxone	ceftriaxone	VBN
10_1101-2021_01_08_423993	305	31	,	,	,
10_1101-2021_01_08_423993	305	32	does	do	VBZ
10_1101-2021_01_08_423993	305	33	not	not	RB
10_1101-2021_01_08_423993	305	34	interact	interact	VB
10_1101-2021_01_08_423993	305	35	with	with	IN
10_1101-2021_01_08_423993	305	36	the	the	DT
10_1101-2021_01_08_423993	305	37	nickel	nickel	NN
10_1101-2021_01_08_423993	305	38	ion	ion	NN
10_1101-2021_01_08_423993	305	39	via	via	IN
10_1101-2021_01_08_423993	305	40	its	-PRON-	PRP$
10_1101-2021_01_08_423993	305	41	b	b	NNP
10_1101-2021_01_08_423993	305	42	-	-	HYPH
10_1101-2021_01_08_423993	305	43	lactam	lactam	NNP
10_1101-2021_01_08_423993	305	44	ring	ring	NNP
10_1101-2021_01_08_423993	305	45	(	(	-LRB-
10_1101-2021_01_08_423993	305	46	as	as	IN
10_1101-2021_01_08_423993	305	47	occurs	occur	VBZ
10_1101-2021_01_08_423993	305	48	for	for	IN
10_1101-2021_01_08_423993	305	49	the	the	DT
10_1101-2021_01_08_423993	305	50	true	true	JJ
10_1101-2021_01_08_423993	305	51	MBLs	mbl	NNS
10_1101-2021_01_08_423993	305	52	)	)	-RRB-
10_1101-2021_01_08_423993	305	53	,	,	,
10_1101-2021_01_08_423993	305	54	but	but	CC
10_1101-2021_01_08_423993	305	55	via	via	IN
10_1101-2021_01_08_423993	305	56	both	both	DT
10_1101-2021_01_08_423993	305	57	carbonyl	carbonyl	NN
10_1101-2021_01_08_423993	305	58	oxygens	oxygen	NNS
10_1101-2021_01_08_423993	305	59	of	of	IN
10_1101-2021_01_08_423993	305	60	the	the	DT
10_1101-2021_01_08_423993	305	61	cyclic	cyclic	JJ
10_1101-2021_01_08_423993	305	62	1	1	CD
10_1101-2021_01_08_423993	305	63	,	,	,
10_1101-2021_01_08_423993	305	64	2	2	CD
10_1101-2021_01_08_423993	305	65	diamide	diamide	NN
10_1101-2021_01_08_423993	305	66	in	in	IN
10_1101-2021_01_08_423993	305	67	its	-PRON-	PRP$
10_1101-2021_01_08_423993	305	68	sidechain	sidechain	NN
10_1101-2021_01_08_423993	305	69	(	(	-LRB-
10_1101-2021_01_08_423993	305	70	Ni	Ni	NNP
10_1101-2021_01_08_423993	305	71	-	-	HYPH
10_1101-2021_01_08_423993	305	72	O	o	NN
10_1101-2021_01_08_423993	305	73	distances	distance	NNS
10_1101-2021_01_08_423993	305	74	:	:	:
10_1101-2021_01_08_423993	305	75	2	2	CD
10_1101-2021_01_08_423993	305	76	Å	å	NN
10_1101-2021_01_08_423993	305	77	and	and	CC
10_1101-2021_01_08_423993	305	78	2.2	2.2	CD
10_1101-2021_01_08_423993	305	79	Å	å	NN
10_1101-2021_01_08_423993	305	80	)	)	-RRB-
10_1101-2021_01_08_423993	305	81	,	,	,
10_1101-2021_01_08_423993	305	82	i.e.	i.e.	FW
10_1101-2021_01_08_423993	306	1	it	-PRON-	PRP
10_1101-2021_01_08_423993	306	2	is	be	VBZ
10_1101-2021_01_08_423993	306	3	not	not	RB
10_1101-2021_01_08_423993	306	4	positioned	position	VBN
10_1101-2021_01_08_423993	306	5	for	for	IN
10_1101-2021_01_08_423993	306	6	productive	productive	JJ
10_1101-2021_01_08_423993	306	7	b	b	NNP
10_1101-2021_01_08_423993	306	8	-	-	HYPH
10_1101-2021_01_08_423993	306	9	lactam	lactam	NNP
10_1101-2021_01_08_423993	306	10	hydrolysis	hydrolysis	NN
10_1101-2021_01_08_423993	306	11	.	.	.
10_1101-2021_01_08_423993	307	1	The	the	DT
10_1101-2021_01_08_423993	307	2	amino	amino	NN
10_1101-2021_01_08_423993	307	3	-	-	HYPH
10_1101-2021_01_08_423993	307	4	thiazole	thiazole	NN
10_1101-2021_01_08_423993	307	5	group	group	NN
10_1101-2021_01_08_423993	307	6	(	(	-LRB-
10_1101-2021_01_08_423993	307	7	N7	N7	NNP
10_1101-2021_01_08_423993	307	8	)	)	-RRB-
10_1101-2021_01_08_423993	307	9	of	of	IN
10_1101-2021_01_08_423993	307	10	ceftriaxone	ceftriaxone	JJ
10_1101-2021_01_08_423993	307	11	forms	form	NNS
10_1101-2021_01_08_423993	307	12	hydrogen	hydrogen	NN
10_1101-2021_01_08_423993	307	13	bonds	bond	NNS
10_1101-2021_01_08_423993	307	14	with	with	IN
10_1101-2021_01_08_423993	307	15	the	the	DT
10_1101-2021_01_08_423993	307	16	side	side	NN
10_1101-2021_01_08_423993	307	17	chain	chain	NN
10_1101-2021_01_08_423993	307	18	of	of	IN
10_1101-2021_01_08_423993	307	19	Asn205	asn205	CD
10_1101-2021_01_08_423993	307	20	,	,	,
10_1101-2021_01_08_423993	307	21	while	while	IN
10_1101-2021_01_08_423993	307	22	the	the	DT
10_1101-2021_01_08_423993	307	23	S1	S1	NNS
10_1101-2021_01_08_423993	307	24	of	of	IN
10_1101-2021_01_08_423993	307	25	the	the	DT
10_1101-2021_01_08_423993	307	26	7-aminocephalosporanic	7-aminocephalosporanic	CD
10_1101-2021_01_08_423993	307	27	acid	acid	JJ
10_1101-2021_01_08_423993	307	28	core	core	NN
10_1101-2021_01_08_423993	307	29	of	of	IN
10_1101-2021_01_08_423993	307	30	the	the	DT
10_1101-2021_01_08_423993	307	31	compound	compound	NN
10_1101-2021_01_08_423993	307	32	interacts	interact	VBZ
10_1101-2021_01_08_423993	307	33	with	with	IN
10_1101-2021_01_08_423993	307	34	the	the	DT
10_1101-2021_01_08_423993	307	35	hydroxyl	hydroxyl	NN
10_1101-2021_01_08_423993	307	36	of	of	IN
10_1101-2021_01_08_423993	307	37	Tyr212	tyr212	CD
10_1101-2021_01_08_423993	307	38	through	through	IN
10_1101-2021_01_08_423993	307	39	an	an	DT
10_1101-2021_01_08_423993	307	40	ethylene	ethylene	NN
10_1101-2021_01_08_423993	307	41	glycol	glycol	NN
10_1101-2021_01_08_423993	307	42	molecule	molecule	NN
10_1101-2021_01_08_423993	307	43	.	.	.
10_1101-2021_01_08_423993	308	1	The	the	DT
10_1101-2021_01_08_423993	308	2	rest	rest	NN
10_1101-2021_01_08_423993	308	3	of	of	IN
10_1101-2021_01_08_423993	308	4	the	the	DT
10_1101-2021_01_08_423993	308	5	molecule	molecule	NN
10_1101-2021_01_08_423993	308	6	appears	appear	VBZ
10_1101-2021_01_08_423993	308	7	to	to	TO
10_1101-2021_01_08_423993	308	8	be	be	VB
10_1101-2021_01_08_423993	308	9	flexible	flexible	JJ
10_1101-2021_01_08_423993	308	10	.	.	.
10_1101-2021_01_08_423993	309	1	The	the	DT
10_1101-2021_01_08_423993	309	2	binding	bind	VBG
10_1101-2021_01_08_423993	309	3	mode	mode	NN
10_1101-2021_01_08_423993	309	4	of	of	IN
10_1101-2021_01_08_423993	309	5	ceftriaxone	ceftriaxone	NN
10_1101-2021_01_08_423993	309	6	to	to	IN
10_1101-2021_01_08_423993	309	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	309	8	shown	show	VBN
10_1101-2021_01_08_423993	309	9	in	in	IN
10_1101-2021_01_08_423993	309	10	Figure	Figure	NNP
10_1101-2021_01_08_423993	309	11	10C	10C	NNP
10_1101-2021_01_08_423993	309	12	is	be	VBZ
10_1101-2021_01_08_423993	309	13	near	near	IN
10_1101-2021_01_08_423993	309	14	identical	identical	JJ
10_1101-2021_01_08_423993	309	15	to	to	IN
10_1101-2021_01_08_423993	309	16	that	that	DT
10_1101-2021_01_08_423993	309	17	observed	observe	VBN
10_1101-2021_01_08_423993	309	18	for	for	IN
10_1101-2021_01_08_423993	309	19	ceftriaxone	ceftriaxone	NN
10_1101-2021_01_08_423993	309	20	with	with	IN
10_1101-2021_01_08_423993	309	21	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	309	22	(	(	-LRB-
10_1101-2021_01_08_423993	309	23	PDB	PDB	NNP
10_1101-2021_01_08_423993	309	24	:	:	:
10_1101-2021_01_08_423993	309	25	5NZW	5NZW	NNP
10_1101-2021_01_08_423993	309	26	)	)	-RRB-
10_1101-2021_01_08_423993	309	27	structure	structure	NN
10_1101-2021_01_08_423993	309	28	(	(	-LRB-
10_1101-2021_01_08_423993	309	29	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	309	30	.	.	.
10_1101-2021_01_08_423993	310	1	Figure	figure	NN
10_1101-2021_01_08_423993	310	2	11	11	CD
10_1101-2021_01_08_423993	310	3	)	)	-RRB-
10_1101-2021_01_08_423993	310	4	.	.	.
10_1101-2021_01_08_423993	311	1	One	one	CD
10_1101-2021_01_08_423993	311	2	notable	notable	JJ
10_1101-2021_01_08_423993	311	3	difference	difference	NN
10_1101-2021_01_08_423993	311	4	between	between	IN
10_1101-2021_01_08_423993	311	5	the	the	DT
10_1101-2021_01_08_423993	311	6	Ceftriaxone	Ceftriaxone	NNP
10_1101-2021_01_08_423993	311	7	-	-	HYPH
10_1101-2021_01_08_423993	311	8	bound	bind	VBN
10_1101-2021_01_08_423993	311	9	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	311	10	structure	structure	NN
10_1101-2021_01_08_423993	311	11	and	and	CC
10_1101-2021_01_08_423993	311	12	the	the	DT
10_1101-2021_01_08_423993	311	13	apo	apo	NNP
10_1101-2021_01_08_423993	311	14	structure	structure	NN
10_1101-2021_01_08_423993	311	15	,	,	,
10_1101-2021_01_08_423993	311	16	is	be	VBZ
10_1101-2021_01_08_423993	311	17	the	the	DT
10_1101-2021_01_08_423993	311	18	loss	loss	NN
10_1101-2021_01_08_423993	311	19	of	of	IN
10_1101-2021_01_08_423993	311	20	a	a	DT
10_1101-2021_01_08_423993	311	21	second	second	JJ
10_1101-2021_01_08_423993	311	22	metal	metal	NN
10_1101-2021_01_08_423993	311	23	ion	ion	NN
10_1101-2021_01_08_423993	311	24	at	at	IN
10_1101-2021_01_08_423993	311	25	the	the	DT
10_1101-2021_01_08_423993	311	26	active	active	JJ
10_1101-2021_01_08_423993	311	27	site	site	NN
10_1101-2021_01_08_423993	311	28	(	(	-LRB-
10_1101-2021_01_08_423993	311	29	Figure	Figure	NNP
10_1101-2021_01_08_423993	311	30	10D	10D	NNP
10_1101-2021_01_08_423993	311	31	)	)	-RRB-
10_1101-2021_01_08_423993	311	32	.	.	.
10_1101-2021_01_08_423993	312	1	In	in	IN
10_1101-2021_01_08_423993	312	2	the	the	DT
10_1101-2021_01_08_423993	312	3	apo	apo	NN
10_1101-2021_01_08_423993	312	4	structure	structure	NN
10_1101-2021_01_08_423993	312	5	(	(	-LRB-
10_1101-2021_01_08_423993	312	6	Figure	figure	NN
10_1101-2021_01_08_423993	312	7	2C	2c	NN
10_1101-2021_01_08_423993	312	8	)	)	-RRB-
10_1101-2021_01_08_423993	312	9	,	,	,
10_1101-2021_01_08_423993	312	10	this	this	DT
10_1101-2021_01_08_423993	312	11	zinc	zinc	NN
10_1101-2021_01_08_423993	312	12	ion	ion	NN
10_1101-2021_01_08_423993	312	13	is	be	VBZ
10_1101-2021_01_08_423993	312	14	coordinated	coordinate	VBN
10_1101-2021_01_08_423993	312	15	by	by	IN
10_1101-2021_01_08_423993	312	16	residues	residue	NNS
10_1101-2021_01_08_423993	312	17	Asp37	Asp37	NNP
10_1101-2021_01_08_423993	312	18	,	,	,
10_1101-2021_01_08_423993	312	19	His38	His38	NNP
10_1101-2021_01_08_423993	312	20	,	,	,
10_1101-2021_01_08_423993	312	21	and	and	CC
10_1101-2021_01_08_423993	312	22	Asp130	asp130	CD
10_1101-2021_01_08_423993	312	23	.	.	.
10_1101-2021_01_08_423993	313	1	With	with	IN
10_1101-2021_01_08_423993	313	2	a	a	DT
10_1101-2021_01_08_423993	313	3	single	single	JJ
10_1101-2021_01_08_423993	313	4	metal	metal	NN
10_1101-2021_01_08_423993	313	5	coordination	coordination	NN
10_1101-2021_01_08_423993	313	6	in	in	IN
10_1101-2021_01_08_423993	313	7	the	the	DT
10_1101-2021_01_08_423993	313	8	ceftriaxone	ceftriaxone	NN
10_1101-2021_01_08_423993	313	9	bound	bind	VBN
10_1101-2021_01_08_423993	313	10	structure	structure	NN
10_1101-2021_01_08_423993	313	11	,	,	,
10_1101-2021_01_08_423993	313	12	the	the	DT
10_1101-2021_01_08_423993	313	13	Asp37	Asp37	NNP
10_1101-2021_01_08_423993	313	14	side	side	NN
10_1101-2021_01_08_423993	313	15	chain	chain	NN
10_1101-2021_01_08_423993	313	16	is	be	VBZ
10_1101-2021_01_08_423993	313	17	positioned	position	VBN
10_1101-2021_01_08_423993	313	18	away	away	RB
10_1101-2021_01_08_423993	313	19	from	from	IN
10_1101-2021_01_08_423993	313	20	the	the	DT
10_1101-2021_01_08_423993	313	21	active	active	JJ
10_1101-2021_01_08_423993	313	22	site	site	NN
10_1101-2021_01_08_423993	313	23	(	(	-LRB-
10_1101-2021_01_08_423993	313	24	Figure	Figure	NNP
10_1101-2021_01_08_423993	313	25	10D	10D	NNP
10_1101-2021_01_08_423993	313	26	)	)	-RRB-
10_1101-2021_01_08_423993	313	27	,	,	,
10_1101-2021_01_08_423993	313	28	as	as	IN
10_1101-2021_01_08_423993	313	29	seen	see	VBN
10_1101-2021_01_08_423993	313	30	in	in	IN
10_1101-2021_01_08_423993	313	31	the	the	DT
10_1101-2021_01_08_423993	313	32	nickel	nickel	NN
10_1101-2021_01_08_423993	313	33	bound	bind	VBN
10_1101-2021_01_08_423993	313	34	(	(	-LRB-
10_1101-2021_01_08_423993	313	35	PDB	PDB	NNP
10_1101-2021_01_08_423993	313	36	:	:	:
10_1101-2021_01_08_423993	313	37	6TT5	6tt5	LS
10_1101-2021_01_08_423993	313	38	)	)	-RRB-
10_1101-2021_01_08_423993	313	39	structure	structure	NN
10_1101-2021_01_08_423993	313	40	(	(	-LRB-
10_1101-2021_01_08_423993	313	41	Figure	figure	NN
10_1101-2021_01_08_423993	313	42	2E	2e	NN
10_1101-2021_01_08_423993	313	43	)	)	-RRB-
10_1101-2021_01_08_423993	313	44	.	.	.
10_1101-2021_01_08_423993	314	1	.CC	.CC	NFP
10_1101-2021_01_08_423993	314	2	-	-	:
10_1101-2021_01_08_423993	314	3	BY	by	IN
10_1101-2021_01_08_423993	314	4	4.0	4.0	CD
10_1101-2021_01_08_423993	314	5	International	international	JJ
10_1101-2021_01_08_423993	314	6	licensemade	licensemade	NN
10_1101-2021_01_08_423993	314	7	available	available	JJ
10_1101-2021_01_08_423993	314	8	under	under	IN
10_1101-2021_01_08_423993	314	9	a	a	DT
10_1101-2021_01_08_423993	314	10	(	(	-LRB-
10_1101-2021_01_08_423993	314	11	which	which	WDT
10_1101-2021_01_08_423993	314	12	was	be	VBD
10_1101-2021_01_08_423993	314	13	not	not	RB
10_1101-2021_01_08_423993	314	14	certified	certify	VBN
10_1101-2021_01_08_423993	314	15	by	by	IN
10_1101-2021_01_08_423993	314	16	peer	peer	NN
10_1101-2021_01_08_423993	314	17	review	review	NN
10_1101-2021_01_08_423993	314	18	)	)	-RRB-
10_1101-2021_01_08_423993	314	19	is	be	VBZ
10_1101-2021_01_08_423993	314	20	the	the	DT
10_1101-2021_01_08_423993	314	21	author	author	NN
10_1101-2021_01_08_423993	314	22	/	/	SYM
10_1101-2021_01_08_423993	314	23	funder	funder	NN
10_1101-2021_01_08_423993	314	24	,	,	,
10_1101-2021_01_08_423993	314	25	who	who	WP
10_1101-2021_01_08_423993	314	26	has	have	VBZ
10_1101-2021_01_08_423993	314	27	granted	grant	VBN
10_1101-2021_01_08_423993	314	28	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	314	29	a	a	DT
10_1101-2021_01_08_423993	314	30	license	license	NN
10_1101-2021_01_08_423993	314	31	to	to	TO
10_1101-2021_01_08_423993	314	32	display	display	VB
10_1101-2021_01_08_423993	314	33	the	the	DT
10_1101-2021_01_08_423993	314	34	preprint	preprint	NN
10_1101-2021_01_08_423993	314	35	in	in	IN
10_1101-2021_01_08_423993	314	36	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	314	37	.	.	.
10_1101-2021_01_08_423993	315	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	315	2	is	be	VBZ
10_1101-2021_01_08_423993	315	3	The	the	DT
10_1101-2021_01_08_423993	315	4	copyright	copyright	NN
10_1101-2021_01_08_423993	315	5	holder	holder	NN
10_1101-2021_01_08_423993	315	6	for	for	IN
10_1101-2021_01_08_423993	315	7	this	this	DT
10_1101-2021_01_08_423993	315	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	315	9	version	version	NN
10_1101-2021_01_08_423993	315	10	posted	post	VBD
10_1101-2021_01_08_423993	315	11	January	January	NNP
10_1101-2021_01_08_423993	315	12	8	8	CD
10_1101-2021_01_08_423993	315	13	,	,	,
10_1101-2021_01_08_423993	315	14	2021	2021	CD
10_1101-2021_01_08_423993	315	15	.	.	.
10_1101-2021_01_08_423993	315	16	;	;	:
10_1101-2021_01_08_423993	315	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	315	18	:	:	:
10_1101-2021_01_08_423993	315	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	315	20	preprint	preprint	NN
10_1101-2021_01_08_423993	315	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	315	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2021_01_08_423993	315	23	To	to	TO
10_1101-2021_01_08_423993	315	24	investigate	investigate	VB
10_1101-2021_01_08_423993	315	25	the	the	DT
10_1101-2021_01_08_423993	315	26	possibility	possibility	NN
10_1101-2021_01_08_423993	315	27	of	of	IN
10_1101-2021_01_08_423993	315	28	inhibiting	inhibit	VBG
10_1101-2021_01_08_423993	315	29	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	315	30	through	through	IN
10_1101-2021_01_08_423993	315	31	binding	bind	VBG
10_1101-2021_01_08_423993	315	32	to	to	IN
10_1101-2021_01_08_423993	315	33	the	the	DT
10_1101-2021_01_08_423993	315	34	zinc	zinc	NN
10_1101-2021_01_08_423993	315	35	finger	finger	NN
10_1101-2021_01_08_423993	315	36	motif	motif	NN
10_1101-2021_01_08_423993	315	37	in	in	IN
10_1101-2021_01_08_423993	315	38	the	the	DT
10_1101-2021_01_08_423993	315	39	β	β	NNP
10_1101-2021_01_08_423993	315	40	-	-	HYPH
10_1101-2021_01_08_423993	315	41	CASP	CASP	NNP
10_1101-2021_01_08_423993	315	42	domain	domain	NN
10_1101-2021_01_08_423993	315	43	,	,	,
10_1101-2021_01_08_423993	315	44	we	-PRON-	PRP
10_1101-2021_01_08_423993	315	45	used	use	VBD
10_1101-2021_01_08_423993	315	46	the	the	DT
10_1101-2021_01_08_423993	315	47	fluorescence	fluorescence	NN
10_1101-2021_01_08_423993	315	48	-	-	HYPH
10_1101-2021_01_08_423993	315	49	based	base	VBN
10_1101-2021_01_08_423993	315	50	nuclease	nuclease	NNP
10_1101-2021_01_08_423993	315	51	assay	assay	NNP
10_1101-2021_01_08_423993	315	52	to	to	TO
10_1101-2021_01_08_423993	315	53	test	test	VB
10_1101-2021_01_08_423993	315	54	three	three	CD
10_1101-2021_01_08_423993	315	55	compounds	compound	NNS
10_1101-2021_01_08_423993	315	56	known	know	VBN
10_1101-2021_01_08_423993	315	57	to	to	TO
10_1101-2021_01_08_423993	315	58	react	react	VB
10_1101-2021_01_08_423993	315	59	with	with	IN
10_1101-2021_01_08_423993	315	60	thiol	thiol	NN
10_1101-2021_01_08_423993	315	61	groups	group	NNS
10_1101-2021_01_08_423993	315	62	present	present	JJ
10_1101-2021_01_08_423993	315	63	in	in	IN
10_1101-2021_01_08_423993	315	64	zinc	zinc	NN
10_1101-2021_01_08_423993	315	65	fingers	finger	NNS
10_1101-2021_01_08_423993	315	66	and	and	CC
10_1101-2021_01_08_423993	315	67	which	which	WDT
10_1101-2021_01_08_423993	315	68	result	result	VBP
10_1101-2021_01_08_423993	315	69	in	in	IN
10_1101-2021_01_08_423993	315	70	zinc	zinc	NN
10_1101-2021_01_08_423993	315	71	ion	ion	NN
10_1101-2021_01_08_423993	315	72	displacement	displacement	NN
10_1101-2021_01_08_423993	315	73	,	,	,
10_1101-2021_01_08_423993	315	74	i.e.	i.e.	FW
10_1101-2021_01_08_423993	316	1	ebselen	ebselen	NNP
10_1101-2021_01_08_423993	316	2	[	[	-LRB-
10_1101-2021_01_08_423993	316	3	68	68	CD
10_1101-2021_01_08_423993	316	4	]	]	-RRB-
10_1101-2021_01_08_423993	316	5	,	,	,
10_1101-2021_01_08_423993	316	6	auranofin	auranofin	VB
10_1101-2021_01_08_423993	316	7	[	[	-LRB-
10_1101-2021_01_08_423993	316	8	69	69	CD
10_1101-2021_01_08_423993	316	9	]	]	-RRB-
10_1101-2021_01_08_423993	316	10	and	and	CC
10_1101-2021_01_08_423993	316	11	disulfiram	disulfiram	NNP
10_1101-2021_01_08_423993	316	12	[	[	-LRB-
10_1101-2021_01_08_423993	316	13	70	70	CD
10_1101-2021_01_08_423993	316	14	]	]	-RRB-
10_1101-2021_01_08_423993	316	15	.	.	.
10_1101-2021_01_08_423993	317	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	317	2	found	find	VBD
10_1101-2021_01_08_423993	317	3	that	that	IN
10_1101-2021_01_08_423993	317	4	both	both	DT
10_1101-2021_01_08_423993	317	5	ebselen	ebselen	NNP
10_1101-2021_01_08_423993	317	6	and	and	CC
10_1101-2021_01_08_423993	317	7	disulfiram	disulfiram	NNP
10_1101-2021_01_08_423993	317	8	inhibit	inhibit	VBP
10_1101-2021_01_08_423993	317	9	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	317	10	with	with	IN
10_1101-2021_01_08_423993	317	11	IC50	IC50	NNP
10_1101-2021_01_08_423993	317	12	values	value	NNS
10_1101-2021_01_08_423993	317	13	around	around	IN
10_1101-2021_01_08_423993	317	14	8.5	8.5	CD
10_1101-2021_01_08_423993	317	15	µM	µM	NNP
10_1101-2021_01_08_423993	317	16	and	and	CC
10_1101-2021_01_08_423993	317	17	10.8	10.8	CD
10_1101-2021_01_08_423993	317	18	µM	µM	NNP
10_1101-2021_01_08_423993	317	19	respectively	respectively	RB
10_1101-2021_01_08_423993	317	20	,	,	,
10_1101-2021_01_08_423993	317	21	whilst	whilst	IN
10_1101-2021_01_08_423993	317	22	Auranofin	Auranofin	NNP
10_1101-2021_01_08_423993	317	23	inhibits	inhibit	VBZ
10_1101-2021_01_08_423993	317	24	less	less	RBR
10_1101-2021_01_08_423993	317	25	potently	potently	RB
10_1101-2021_01_08_423993	317	26	(	(	-LRB-
10_1101-2021_01_08_423993	317	27	IC50	IC50	NNP
10_1101-2021_01_08_423993	317	28	46	46	CD
10_1101-2021_01_08_423993	317	29	µM	µM	NNP
10_1101-2021_01_08_423993	317	30	)	)	-RRB-
10_1101-2021_01_08_423993	317	31	(	(	-LRB-
10_1101-2021_01_08_423993	317	32	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	317	33	.	.	.
10_1101-2021_01_08_423993	318	1	Figure	figure	NN
10_1101-2021_01_08_423993	318	2	12	12	CD
10_1101-2021_01_08_423993	318	3	)	)	-RRB-
10_1101-2021_01_08_423993	318	4	,	,	,
10_1101-2021_01_08_423993	318	5	indicating	indicate	VBG
10_1101-2021_01_08_423993	318	6	additional	additional	JJ
10_1101-2021_01_08_423993	318	7	possible	possible	JJ
10_1101-2021_01_08_423993	318	8	inhibitory	inhibitory	JJ
10_1101-2021_01_08_423993	318	9	strategies	strategy	NNS
10_1101-2021_01_08_423993	318	10	.	.	.
10_1101-2021_01_08_423993	319	1	DISCUSSION	DISCUSSION	NNP
10_1101-2021_01_08_423993	319	2	The	the	DT
10_1101-2021_01_08_423993	319	3	DCLRE1C	DCLRE1C	NNP
10_1101-2021_01_08_423993	319	4	/	/	SYM
10_1101-2021_01_08_423993	319	5	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	319	6	gene	gene	NN
10_1101-2021_01_08_423993	319	7	was	be	VBD
10_1101-2021_01_08_423993	319	8	first	first	RB
10_1101-2021_01_08_423993	319	9	discovered	discover	VBN
10_1101-2021_01_08_423993	319	10	in	in	IN
10_1101-2021_01_08_423993	319	11	2000	2000	CD
10_1101-2021_01_08_423993	319	12	,	,	,
10_1101-2021_01_08_423993	319	13	following	follow	VBG
10_1101-2021_01_08_423993	319	14	work	work	NN
10_1101-2021_01_08_423993	319	15	with	with	IN
10_1101-2021_01_08_423993	319	16	children	child	NNS
10_1101-2021_01_08_423993	319	17	with	with	IN
10_1101-2021_01_08_423993	319	18	severe	severe	JJ
10_1101-2021_01_08_423993	319	19	combined	combined	JJ
10_1101-2021_01_08_423993	319	20	immunodeficiency	immunodeficiency	NN
10_1101-2021_01_08_423993	319	21	disease	disease	NN
10_1101-2021_01_08_423993	319	22	(	(	-LRB-
10_1101-2021_01_08_423993	319	23	SCID	SCID	NNP
10_1101-2021_01_08_423993	319	24	)	)	-RRB-
10_1101-2021_01_08_423993	319	25	[	[	-LRB-
10_1101-2021_01_08_423993	319	26	71	71	CD
10_1101-2021_01_08_423993	319	27	]	]	-RRB-
10_1101-2021_01_08_423993	319	28	.	.	.
10_1101-2021_01_08_423993	320	1	Subsequent	subsequent	JJ
10_1101-2021_01_08_423993	320	2	studies	study	NNS
10_1101-2021_01_08_423993	320	3	have	have	VBP
10_1101-2021_01_08_423993	320	4	shown	show	VBN
10_1101-2021_01_08_423993	320	5	that	that	IN
10_1101-2021_01_08_423993	320	6	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	320	7	is	be	VBZ
10_1101-2021_01_08_423993	320	8	a	a	DT
10_1101-2021_01_08_423993	320	9	key	key	JJ
10_1101-2021_01_08_423993	320	10	enzyme	enzyme	NNS
10_1101-2021_01_08_423993	320	11	in	in	IN
10_1101-2021_01_08_423993	320	12	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	320	13	recombination	recombination	NN
10_1101-2021_01_08_423993	320	14	[	[	-LRB-
10_1101-2021_01_08_423993	320	15	16,17,72	16,17,72	NNP
10_1101-2021_01_08_423993	320	16	]	]	-RRB-
10_1101-2021_01_08_423993	320	17	and	and	CC
10_1101-2021_01_08_423993	320	18	the	the	DT
10_1101-2021_01_08_423993	320	19	c	c	NNP
10_1101-2021_01_08_423993	320	20	-	-	HYPH
10_1101-2021_01_08_423993	320	21	NHEJ	NHEJ	NNP
10_1101-2021_01_08_423993	320	22	DNA	DNA	NNP
10_1101-2021_01_08_423993	320	23	repair	repair	NN
10_1101-2021_01_08_423993	320	24	pathway	pathway	NN
10_1101-2021_01_08_423993	320	25	[	[	-LRB-
10_1101-2021_01_08_423993	320	26	21,44,73	21,44,73	CD
10_1101-2021_01_08_423993	320	27	]	]	-RRB-
10_1101-2021_01_08_423993	320	28	;	;	:
10_1101-2021_01_08_423993	320	29	and	and	CC
10_1101-2021_01_08_423993	320	30	that	that	IN
10_1101-2021_01_08_423993	320	31	it	-PRON-	PRP
10_1101-2021_01_08_423993	320	32	is	be	VBZ
10_1101-2021_01_08_423993	320	33	structure	structure	NN
10_1101-2021_01_08_423993	320	34	specific	specific	JJ
10_1101-2021_01_08_423993	320	35	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	320	36	,	,	,
10_1101-2021_01_08_423993	320	37	and	and	CC
10_1101-2021_01_08_423993	320	38	member	member	NN
10_1101-2021_01_08_423993	320	39	of	of	IN
10_1101-2021_01_08_423993	320	40	MBL	MBL	NNP
10_1101-2021_01_08_423993	320	41	fold	fold	VB
10_1101-2021_01_08_423993	320	42	structural	structural	JJ
10_1101-2021_01_08_423993	320	43	superfamily	superfamily	RB
10_1101-2021_01_08_423993	320	44	[	[	-LRB-
10_1101-2021_01_08_423993	320	45	2	2	CD
10_1101-2021_01_08_423993	320	46	]	]	-RRB-
10_1101-2021_01_08_423993	320	47	.	.	.
10_1101-2021_01_08_423993	321	1	Our	-PRON-	PRP$
10_1101-2021_01_08_423993	321	2	structures	structure	NNS
10_1101-2021_01_08_423993	321	3	of	of	IN
10_1101-2021_01_08_423993	321	4	wild	wild	JJ
10_1101-2021_01_08_423993	321	5	-	-	HYPH
10_1101-2021_01_08_423993	321	6	type	type	NN
10_1101-2021_01_08_423993	321	7	and	and	CC
10_1101-2021_01_08_423993	321	8	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	321	9	site	site	NN
10_1101-2021_01_08_423993	321	10	mutants	mutant	NNS
10_1101-2021_01_08_423993	321	11	of	of	IN
10_1101-2021_01_08_423993	321	12	SNM1C	snm1c	NN
10_1101-2021_01_08_423993	321	13	/	/	SYM
10_1101-2021_01_08_423993	321	14	DCLRE1C	dclre1c	UH
10_1101-2021_01_08_423993	321	15	or	or	CC
10_1101-2021_01_08_423993	321	16	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	321	17	protein	protein	NN
10_1101-2021_01_08_423993	321	18	show	show	VBP
10_1101-2021_01_08_423993	321	19	that	that	IN
10_1101-2021_01_08_423993	321	20	,	,	,
10_1101-2021_01_08_423993	321	21	like	like	IN
10_1101-2021_01_08_423993	321	22	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	321	23	and	and	CC
10_1101-2021_01_08_423993	321	24	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	321	25	/	/	SYM
10_1101-2021_01_08_423993	321	26	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	321	27	and	and	CC
10_1101-2021_01_08_423993	321	28	the	the	DT
10_1101-2021_01_08_423993	321	29	RNA	RNA	NNP
10_1101-2021_01_08_423993	321	30	processing	processing	NN
10_1101-2021_01_08_423993	321	31	enzyme	enzyme	NNS
10_1101-2021_01_08_423993	321	32	CPSF73	CPSF73	NNP
10_1101-2021_01_08_423993	321	33	,	,	,
10_1101-2021_01_08_423993	321	34	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	321	35	has	have	VBZ
10_1101-2021_01_08_423993	321	36	a	a	DT
10_1101-2021_01_08_423993	321	37	typical	typical	JJ
10_1101-2021_01_08_423993	321	38	α	α	NNP
10_1101-2021_01_08_423993	321	39	/	/	SYM
10_1101-2021_01_08_423993	321	40	β	β	NNP
10_1101-2021_01_08_423993	321	41	-	-	HYPH
10_1101-2021_01_08_423993	321	42	β	β	NNP
10_1101-2021_01_08_423993	321	43	/	/	SYM
10_1101-2021_01_08_423993	321	44	α	α	NNP
10_1101-2021_01_08_423993	321	45	sandwich	sandwich	NN
10_1101-2021_01_08_423993	321	46	fold	fold	VB
10_1101-2021_01_08_423993	321	47	in	in	IN
10_1101-2021_01_08_423993	321	48	its	-PRON-	PRP$
10_1101-2021_01_08_423993	321	49	MBL	MBL	NNP
10_1101-2021_01_08_423993	321	50	domain	domain	NN
10_1101-2021_01_08_423993	321	51	and	and	CC
10_1101-2021_01_08_423993	321	52	has	have	VBZ
10_1101-2021_01_08_423993	321	53	a	a	DT
10_1101-2021_01_08_423993	321	54	β	β	NNP
10_1101-2021_01_08_423993	321	55	-	-	HYPH
10_1101-2021_01_08_423993	321	56	CASP	casp	NN
10_1101-2021_01_08_423993	321	57	domain	domain	NN
10_1101-2021_01_08_423993	321	58	,	,	,
10_1101-2021_01_08_423993	321	59	the	the	DT
10_1101-2021_01_08_423993	321	60	latter	latter	JJ
10_1101-2021_01_08_423993	321	61	a	a	DT
10_1101-2021_01_08_423993	321	62	characteristic	characteristic	JJ
10_1101-2021_01_08_423993	321	63	feature	feature	NN
10_1101-2021_01_08_423993	321	64	of	of	IN
10_1101-2021_01_08_423993	321	65	MBL	MBL	NNP
10_1101-2021_01_08_423993	321	66	fold	fold	JJ
10_1101-2021_01_08_423993	321	67	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	321	68	.	.	.
10_1101-2021_01_08_423993	322	1	However	however	RB
10_1101-2021_01_08_423993	322	2	,	,	,
10_1101-2021_01_08_423993	322	3	both	both	CC
10_1101-2021_01_08_423993	322	4	our	-PRON-	PRP$
10_1101-2021_01_08_423993	322	5	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	322	6	structures	structure	NNS
10_1101-2021_01_08_423993	322	7	and	and	CC
10_1101-2021_01_08_423993	322	8	those	those	DT
10_1101-2021_01_08_423993	322	9	recently	recently	RB
10_1101-2021_01_08_423993	322	10	reported	report	VBN
10_1101-2021_01_08_423993	322	11	by	by	IN
10_1101-2021_01_08_423993	322	12	Karim	Karim	NNP
10_1101-2021_01_08_423993	322	13	et	et	NNP
10_1101-2021_01_08_423993	322	14	.	.	.
10_1101-2021_01_08_423993	323	1	al	al	NNP
10_1101-2021_01_08_423993	323	2	[	[	-LRB-
10_1101-2021_01_08_423993	323	3	56	56	CD
10_1101-2021_01_08_423993	323	4	]	]	-RRB-
10_1101-2021_01_08_423993	323	5	reveal	reveal	VB
10_1101-2021_01_08_423993	323	6	a	a	DT
10_1101-2021_01_08_423993	323	7	unique	unique	JJ
10_1101-2021_01_08_423993	323	8	structural	structural	JJ
10_1101-2021_01_08_423993	323	9	feature	feature	NN
10_1101-2021_01_08_423993	323	10	of	of	IN
10_1101-2021_01_08_423993	323	11	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	323	12	in	in	IN
10_1101-2021_01_08_423993	323	13	its	-PRON-	PRP$
10_1101-2021_01_08_423993	323	14	β	β	NNP
10_1101-2021_01_08_423993	323	15	-	-	HYPH
10_1101-2021_01_08_423993	323	16	CASP	CASP	NNP
10_1101-2021_01_08_423993	323	17	domain	domain	NN
10_1101-2021_01_08_423993	323	18	that	that	WDT
10_1101-2021_01_08_423993	323	19	is	be	VBZ
10_1101-2021_01_08_423993	323	20	not	not	RB
10_1101-2021_01_08_423993	323	21	reported	report	VBN
10_1101-2021_01_08_423993	323	22	in	in	IN
10_1101-2021_01_08_423993	323	23	other	other	JJ
10_1101-2021_01_08_423993	323	24	human	human	JJ
10_1101-2021_01_08_423993	323	25	MBL	MBL	NNP
10_1101-2021_01_08_423993	323	26	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	323	27	,	,	,
10_1101-2021_01_08_423993	323	28	i.e.	i.e.	FW
10_1101-2021_01_08_423993	324	1	a	a	DT
10_1101-2021_01_08_423993	324	2	classical	classical	JJ
10_1101-2021_01_08_423993	324	3	zinc	zinc	NN
10_1101-2021_01_08_423993	324	4	-	-	HYPH
10_1101-2021_01_08_423993	324	5	finger	finger	NN
10_1101-2021_01_08_423993	324	6	like	like	IN
10_1101-2021_01_08_423993	324	7	motif	motif	NN
10_1101-2021_01_08_423993	324	8	.	.	.
10_1101-2021_01_08_423993	325	1	Moreover	moreover	RB
10_1101-2021_01_08_423993	325	2	,	,	,
10_1101-2021_01_08_423993	325	3	collectively	collectively	RB
10_1101-2021_01_08_423993	325	4	,	,	,
10_1101-2021_01_08_423993	325	5	these	these	DT
10_1101-2021_01_08_423993	325	6	structures	structure	NNS
10_1101-2021_01_08_423993	325	7	allow	allow	VBP
10_1101-2021_01_08_423993	325	8	us	-PRON-	PRP
10_1101-2021_01_08_423993	325	9	to	to	TO
10_1101-2021_01_08_423993	325	10	assign	assign	VB
10_1101-2021_01_08_423993	325	11	a	a	DT
10_1101-2021_01_08_423993	325	12	likely	likely	JJ
10_1101-2021_01_08_423993	325	13	mode	mode	NN
10_1101-2021_01_08_423993	325	14	of	of	IN
10_1101-2021_01_08_423993	325	15	DNA	dna	NN
10_1101-2021_01_08_423993	325	16	substrate	substrate	NN
10_1101-2021_01_08_423993	325	17	interaction	interaction	NN
10_1101-2021_01_08_423993	325	18	for	for	IN
10_1101-2021_01_08_423993	325	19	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	325	20	.	.	.
10_1101-2021_01_08_423993	326	1	The	the	DT
10_1101-2021_01_08_423993	326	2	role	role	NN
10_1101-2021_01_08_423993	326	3	of	of	IN
10_1101-2021_01_08_423993	326	4	the	the	DT
10_1101-2021_01_08_423993	326	5	newly	newly	RB
10_1101-2021_01_08_423993	326	6	-	-	HYPH
10_1101-2021_01_08_423993	326	7	described	describe	VBN
10_1101-2021_01_08_423993	326	8	zinc	zinc	NN
10_1101-2021_01_08_423993	326	9	-	-	HYPH
10_1101-2021_01_08_423993	326	10	finger	finger	NN
10_1101-2021_01_08_423993	326	11	like	like	IN
10_1101-2021_01_08_423993	326	12	motif	motif	NN
10_1101-2021_01_08_423993	326	13	remains	remain	VBZ
10_1101-2021_01_08_423993	326	14	unknown	unknown	JJ
10_1101-2021_01_08_423993	326	15	.	.	.
10_1101-2021_01_08_423993	327	1	However	however	RB
10_1101-2021_01_08_423993	327	2	,	,	,
10_1101-2021_01_08_423993	327	3	zinc-	zinc-	JJ
10_1101-2021_01_08_423993	327	4	finger	finger	NN
10_1101-2021_01_08_423993	327	5	motifs	motif	NNS
10_1101-2021_01_08_423993	327	6	are	be	VBP
10_1101-2021_01_08_423993	327	7	common	common	JJ
10_1101-2021_01_08_423993	327	8	structural	structural	JJ
10_1101-2021_01_08_423993	327	9	features	feature	NNS
10_1101-2021_01_08_423993	327	10	in	in	IN
10_1101-2021_01_08_423993	327	11	DNA	dna	NN
10_1101-2021_01_08_423993	327	12	binding	bind	VBG
10_1101-2021_01_08_423993	327	13	proteins	protein	NNS
10_1101-2021_01_08_423993	327	14	such	such	JJ
10_1101-2021_01_08_423993	327	15	as	as	IN
10_1101-2021_01_08_423993	327	16	transcription	transcription	NN
10_1101-2021_01_08_423993	327	17	factors	factor	NNS
10_1101-2021_01_08_423993	327	18	[	[	-LRB-
10_1101-2021_01_08_423993	327	19	50,54	50,54	CD
10_1101-2021_01_08_423993	327	20	]	]	-RRB-
10_1101-2021_01_08_423993	327	21	,	,	,
10_1101-2021_01_08_423993	327	22	but	but	CC
10_1101-2021_01_08_423993	327	23	are	be	VBP
10_1101-2021_01_08_423993	327	24	also	also	RB
10_1101-2021_01_08_423993	327	25	observed	observe	VBN
10_1101-2021_01_08_423993	327	26	in	in	IN
10_1101-2021_01_08_423993	327	27	a	a	DT
10_1101-2021_01_08_423993	327	28	substantial	substantial	JJ
10_1101-2021_01_08_423993	327	29	number	number	NN
10_1101-2021_01_08_423993	327	30	of	of	IN
10_1101-2021_01_08_423993	327	31	required	require	VBN
10_1101-2021_01_08_423993	327	32	and	and	CC
10_1101-2021_01_08_423993	327	33	accessory	accessory	JJ
10_1101-2021_01_08_423993	327	34	NHEJ	NHEJ	NNP
10_1101-2021_01_08_423993	327	35	proteins	protein	VBZ
10_1101-2021_01_08_423993	327	36	[	[	-LRB-
10_1101-2021_01_08_423993	327	37	52	52	CD
10_1101-2021_01_08_423993	327	38	]	]	-RRB-
10_1101-2021_01_08_423993	327	39	.	.	.
10_1101-2021_01_08_423993	328	1	These	these	DT
10_1101-2021_01_08_423993	328	2	zinc	zinc	NN
10_1101-2021_01_08_423993	328	3	fingers	finger	NNS
10_1101-2021_01_08_423993	328	4	provide	provide	VBP
10_1101-2021_01_08_423993	328	5	structural	structural	JJ
10_1101-2021_01_08_423993	328	6	stability	stability	NN
10_1101-2021_01_08_423993	328	7	and	and	CC
10_1101-2021_01_08_423993	328	8	enhance	enhance	VB
10_1101-2021_01_08_423993	328	9	substrate	substrate	NN
10_1101-2021_01_08_423993	328	10	selectivity	selectivity	NN
10_1101-2021_01_08_423993	328	11	rather	rather	RB
10_1101-2021_01_08_423993	328	12	than	than	IN
10_1101-2021_01_08_423993	328	13	being	be	VBG
10_1101-2021_01_08_423993	328	14	involved	involve	VBN
10_1101-2021_01_08_423993	328	15	in	in	IN
10_1101-2021_01_08_423993	328	16	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	328	17	reactions	reaction	NNS
10_1101-2021_01_08_423993	328	18	,	,	,
10_1101-2021_01_08_423993	328	19	and	and	CC
10_1101-2021_01_08_423993	328	20	we	-PRON-	PRP
10_1101-2021_01_08_423993	328	21	propose	propose	VBP
10_1101-2021_01_08_423993	328	22	that	that	IN
10_1101-2021_01_08_423993	328	23	this	this	DT
10_1101-2021_01_08_423993	328	24	is	be	VBZ
10_1101-2021_01_08_423993	328	25	likely	likely	JJ
10_1101-2021_01_08_423993	328	26	to	to	TO
10_1101-2021_01_08_423993	328	27	be	be	VB
10_1101-2021_01_08_423993	328	28	the	the	DT
10_1101-2021_01_08_423993	328	29	case	case	NN
10_1101-2021_01_08_423993	328	30	for	for	IN
10_1101-2021_01_08_423993	328	31	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	328	32	.	.	.
10_1101-2021_01_08_423993	329	1	The	the	DT
10_1101-2021_01_08_423993	329	2	fact	fact	NN
10_1101-2021_01_08_423993	329	3	that	that	IN
10_1101-2021_01_08_423993	329	4	the	the	DT
10_1101-2021_01_08_423993	329	5	residues	residue	NNS
10_1101-2021_01_08_423993	329	6	(	(	-LRB-
10_1101-2021_01_08_423993	329	7	His	-PRON-	PRP$
10_1101-2021_01_08_423993	329	8	228	228	CD
10_1101-2021_01_08_423993	329	9	,	,	,
10_1101-2021_01_08_423993	329	10	His	-PRON-	PRP$
10_1101-2021_01_08_423993	329	11	254	254	CD
10_1101-2021_01_08_423993	329	12	,	,	,
10_1101-2021_01_08_423993	329	13	Cys	Cys	NNP
10_1101-2021_01_08_423993	329	14	256	256	CD
10_1101-2021_01_08_423993	329	15	,	,	,
10_1101-2021_01_08_423993	329	16	and	and	CC
10_1101-2021_01_08_423993	329	17	Cys	Cys	NNP
10_1101-2021_01_08_423993	329	18	272	272	CD
10_1101-2021_01_08_423993	329	19	)	)	-RRB-
10_1101-2021_01_08_423993	329	20	that	that	WDT
10_1101-2021_01_08_423993	329	21	are	be	VBP
10_1101-2021_01_08_423993	329	22	involved	involve	VBN
10_1101-2021_01_08_423993	329	23	in	in	IN
10_1101-2021_01_08_423993	329	24	the	the	DT
10_1101-2021_01_08_423993	329	25	zinc	zinc	NN
10_1101-2021_01_08_423993	329	26	-	-	HYPH
10_1101-2021_01_08_423993	329	27	finger	finger	NN
10_1101-2021_01_08_423993	329	28	like	like	IN
10_1101-2021_01_08_423993	329	29	motif	motif	NN
10_1101-2021_01_08_423993	329	30	are	be	VBP
10_1101-2021_01_08_423993	329	31	highly	highly	RB
10_1101-2021_01_08_423993	329	32	conserved	conserve	VBN
10_1101-2021_01_08_423993	329	33	across	across	IN
10_1101-2021_01_08_423993	329	34	different	different	JJ
10_1101-2021_01_08_423993	329	35	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	329	36	species	specie	NNS
10_1101-2021_01_08_423993	329	37	suggests	suggest	VBZ
10_1101-2021_01_08_423993	329	38	the	the	DT
10_1101-2021_01_08_423993	329	39	importance	importance	NN
10_1101-2021_01_08_423993	329	40	of	of	IN
10_1101-2021_01_08_423993	329	41	this	this	DT
10_1101-2021_01_08_423993	329	42	structural	structural	JJ
10_1101-2021_01_08_423993	329	43	feature	feature	NN
10_1101-2021_01_08_423993	329	44	.	.	.
10_1101-2021_01_08_423993	330	1	Furthermore	furthermore	RB
10_1101-2021_01_08_423993	330	2	,	,	,
10_1101-2021_01_08_423993	330	3	point	point	NN
10_1101-2021_01_08_423993	330	4	mutations	mutation	NNS
10_1101-2021_01_08_423993	330	5	in	in	IN
10_1101-2021_01_08_423993	330	6	His	-PRON-	PRP$
10_1101-2021_01_08_423993	330	7	228	228	CD
10_1101-2021_01_08_423993	330	8	and	and	CC
10_1101-2021_01_08_423993	330	9	His	-PRON-	PRP$
10_1101-2021_01_08_423993	330	10	254	254	CD
10_1101-2021_01_08_423993	330	11	(	(	-LRB-
10_1101-2021_01_08_423993	330	12	H228N	H228N	NNP
10_1101-2021_01_08_423993	330	13	and	and	CC
10_1101-2021_01_08_423993	330	14	H254L	h254l	CD
10_1101-2021_01_08_423993	330	15	)	)	-RRB-
10_1101-2021_01_08_423993	330	16	have	have	VBP
10_1101-2021_01_08_423993	330	17	been	be	VBN
10_1101-2021_01_08_423993	330	18	reported	report	VBN
10_1101-2021_01_08_423993	330	19	in	in	IN
10_1101-2021_01_08_423993	330	20	patients	patient	NNS
10_1101-2021_01_08_423993	330	21	with	with	IN
10_1101-2021_01_08_423993	330	22	a	a	DT
10_1101-2021_01_08_423993	330	23	SCID	SCID	NNP
10_1101-2021_01_08_423993	330	24	phenotype	phenotype	NN
10_1101-2021_01_08_423993	330	25	[	[	-LRB-
10_1101-2021_01_08_423993	330	26	55	55	CD
10_1101-2021_01_08_423993	330	27	]	]	-RRB-
10_1101-2021_01_08_423993	330	28	.	.	.
10_1101-2021_01_08_423993	331	1	The	the	DT
10_1101-2021_01_08_423993	331	2	presence	presence	NN
10_1101-2021_01_08_423993	331	3	of	of	IN
10_1101-2021_01_08_423993	331	4	one	one	CD
10_1101-2021_01_08_423993	331	5	or	or	CC
10_1101-2021_01_08_423993	331	6	two	two	CD
10_1101-2021_01_08_423993	331	7	metal	metal	NN
10_1101-2021_01_08_423993	331	8	ions	ion	NNS
10_1101-2021_01_08_423993	331	9	coordinated	coordinate	VBN
10_1101-2021_01_08_423993	331	10	by	by	IN
10_1101-2021_01_08_423993	331	11	the	the	DT
10_1101-2021_01_08_423993	331	12	HxHxDH	hxhxdh	JJ
10_1101-2021_01_08_423993	331	13	motif	motif	NN
10_1101-2021_01_08_423993	331	14	at	at	IN
10_1101-2021_01_08_423993	331	15	the	the	DT
10_1101-2021_01_08_423993	331	16	active	active	JJ
10_1101-2021_01_08_423993	331	17	site	site	NN
10_1101-2021_01_08_423993	331	18	of	of	IN
10_1101-2021_01_08_423993	331	19	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	331	20	reflects	reflect	VBZ
10_1101-2021_01_08_423993	331	21	a	a	DT
10_1101-2021_01_08_423993	331	22	hallmark	hallmark	NN
10_1101-2021_01_08_423993	331	23	of	of	IN
10_1101-2021_01_08_423993	331	24	the	the	DT
10_1101-2021_01_08_423993	331	25	SNM1	SNM1	NNP
10_1101-2021_01_08_423993	331	26	enzyme	enzyme	NNS
10_1101-2021_01_08_423993	331	27	family	family	NN
10_1101-2021_01_08_423993	331	28	[	[	-LRB-
10_1101-2021_01_08_423993	331	29	9,74	9,74	CD
10_1101-2021_01_08_423993	331	30	]	]	-RRB-
10_1101-2021_01_08_423993	331	31	;	;	:
10_1101-2021_01_08_423993	331	32	the	the	DT
10_1101-2021_01_08_423993	331	33	available	available	JJ
10_1101-2021_01_08_423993	331	34	evidence	evidence	NN
10_1101-2021_01_08_423993	331	35	implies	imply	VBZ
10_1101-2021_01_08_423993	331	36	that	that	IN
10_1101-2021_01_08_423993	331	37	metal	metal	NN
10_1101-2021_01_08_423993	331	38	ion	ion	NN
10_1101-2021_01_08_423993	331	39	binding	bind	VBG
10_1101-2021_01_08_423993	331	40	at	at	IN
10_1101-2021_01_08_423993	331	41	one	one	CD
10_1101-2021_01_08_423993	331	42	site	site	NN
10_1101-2021_01_08_423993	331	43	(	(	-LRB-
10_1101-2021_01_08_423993	331	44	Zn1	zn1	NN
10_1101-2021_01_08_423993	331	45	site	site	NN
10_1101-2021_01_08_423993	331	46	in	in	IN
10_1101-2021_01_08_423993	331	47	standard	standard	JJ
10_1101-2021_01_08_423993	331	48	MBL	MBL	NNP
10_1101-2021_01_08_423993	331	49	nomenclature	nomenclature	NN
10_1101-2021_01_08_423993	331	50	)	)	-RRB-
10_1101-2021_01_08_423993	331	51	is	be	VBZ
10_1101-2021_01_08_423993	331	52	stronger	strong	JJR
10_1101-2021_01_08_423993	331	53	than	than	IN
10_1101-2021_01_08_423993	331	54	at	at	IN
10_1101-2021_01_08_423993	331	55	the	the	DT
10_1101-2021_01_08_423993	331	56	other	other	JJ
10_1101-2021_01_08_423993	331	57	(	(	-LRB-
10_1101-2021_01_08_423993	331	58	Zn2	Zn2	NNP
10_1101-2021_01_08_423993	331	59	site	site	NN
10_1101-2021_01_08_423993	331	60	)	)	-RRB-
10_1101-2021_01_08_423993	331	61	.	.	.
10_1101-2021_01_08_423993	332	1	By	by	IN
10_1101-2021_01_08_423993	332	2	analogy	analogy	NN
10_1101-2021_01_08_423993	332	3	with	with	IN
10_1101-2021_01_08_423993	332	4	studies	study	NNS
10_1101-2021_01_08_423993	332	5	on	on	IN
10_1101-2021_01_08_423993	332	6	the	the	DT
10_1101-2021_01_08_423993	332	7	true	true	JJ
10_1101-2021_01_08_423993	332	8	MBLs	mbl	NNS
10_1101-2021_01_08_423993	332	9	,	,	,
10_1101-2021_01_08_423993	332	10	these	these	DT
10_1101-2021_01_08_423993	332	11	metal	metal	NN
10_1101-2021_01_08_423993	332	12	ions	ion	NNS
10_1101-2021_01_08_423993	332	13	are	be	VBP
10_1101-2021_01_08_423993	332	14	proposed	propose	VBN
10_1101-2021_01_08_423993	332	15	to	to	TO
10_1101-2021_01_08_423993	332	16	activate	activate	VB
10_1101-2021_01_08_423993	332	17	a	a	DT
10_1101-2021_01_08_423993	332	18	water	water	NN
10_1101-2021_01_08_423993	332	19	molecule	molecule	NN
10_1101-2021_01_08_423993	332	20	that	that	DT
10_1101-2021_01_08_423993	332	21	act	act	NN
10_1101-2021_01_08_423993	332	22	as	as	IN
10_1101-2021_01_08_423993	332	23	the	the	DT
10_1101-2021_01_08_423993	332	24	nucleophile	nucleophile	NN
10_1101-2021_01_08_423993	332	25	for	for	IN
10_1101-2021_01_08_423993	332	26	the	the	DT
10_1101-2021_01_08_423993	332	27	phosphodiester	phosphodiester	NN
10_1101-2021_01_08_423993	332	28	cleavage	cleavage	NN
10_1101-2021_01_08_423993	332	29	.	.	.
10_1101-2021_01_08_423993	333	1	Our	-PRON-	PRP$
10_1101-2021_01_08_423993	333	2	structure	structure	NN
10_1101-2021_01_08_423993	333	3	(	(	-LRB-
10_1101-2021_01_08_423993	333	4	PDB	PDB	NNP
10_1101-2021_01_08_423993	333	5	:	:	:
10_1101-2021_01_08_423993	333	6	7AF1	7af1	LS
10_1101-2021_01_08_423993	333	7	)	)	-RRB-
10_1101-2021_01_08_423993	333	8	suggests	suggest	VBZ
10_1101-2021_01_08_423993	333	9	that	that	IN
10_1101-2021_01_08_423993	333	10	the	the	DT
10_1101-2021_01_08_423993	333	11	native	native	JJ
10_1101-2021_01_08_423993	333	12	metal	metal	NN
10_1101-2021_01_08_423993	333	13	ion(s	ion(s	.
10_1101-2021_01_08_423993	333	14	)	)	-RRB-
10_1101-2021_01_08_423993	333	15	residing	reside	VBG
10_1101-2021_01_08_423993	333	16	in	in	IN
10_1101-2021_01_08_423993	333	17	the	the	DT
10_1101-2021_01_08_423993	333	18	active	active	JJ
10_1101-2021_01_08_423993	333	19	site	site	NN
10_1101-2021_01_08_423993	333	20	of	of	IN
10_1101-2021_01_08_423993	333	21	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	333	22	is	be	VBZ
10_1101-2021_01_08_423993	333	23	zinc	zinc	NN
10_1101-2021_01_08_423993	333	24	,	,	,
10_1101-2021_01_08_423993	333	25	although	although	IN
10_1101-2021_01_08_423993	333	26	a	a	DT
10_1101-2021_01_08_423993	333	27	nickel	nickel	NN
10_1101-2021_01_08_423993	333	28	ion	ion	NN
10_1101-2021_01_08_423993	333	29	can	can	MD
10_1101-2021_01_08_423993	333	30	also	also	RB
10_1101-2021_01_08_423993	333	31	occupy	occupy	VB
10_1101-2021_01_08_423993	333	32	the	the	DT
10_1101-2021_01_08_423993	333	33	same	same	JJ
10_1101-2021_01_08_423993	333	34	.CC	.CC	:
10_1101-2021_01_08_423993	333	35	-	-	:
10_1101-2021_01_08_423993	333	36	BY	by	IN
10_1101-2021_01_08_423993	333	37	4.0	4.0	CD
10_1101-2021_01_08_423993	333	38	International	international	JJ
10_1101-2021_01_08_423993	333	39	licensemade	licensemade	NN
10_1101-2021_01_08_423993	333	40	available	available	JJ
10_1101-2021_01_08_423993	333	41	under	under	IN
10_1101-2021_01_08_423993	333	42	a	a	DT
10_1101-2021_01_08_423993	333	43	(	(	-LRB-
10_1101-2021_01_08_423993	333	44	which	which	WDT
10_1101-2021_01_08_423993	333	45	was	be	VBD
10_1101-2021_01_08_423993	333	46	not	not	RB
10_1101-2021_01_08_423993	333	47	certified	certify	VBN
10_1101-2021_01_08_423993	333	48	by	by	IN
10_1101-2021_01_08_423993	333	49	peer	peer	NN
10_1101-2021_01_08_423993	333	50	review	review	NN
10_1101-2021_01_08_423993	333	51	)	)	-RRB-
10_1101-2021_01_08_423993	333	52	is	be	VBZ
10_1101-2021_01_08_423993	333	53	the	the	DT
10_1101-2021_01_08_423993	333	54	author	author	NN
10_1101-2021_01_08_423993	333	55	/	/	SYM
10_1101-2021_01_08_423993	333	56	funder	funder	NN
10_1101-2021_01_08_423993	333	57	,	,	,
10_1101-2021_01_08_423993	333	58	who	who	WP
10_1101-2021_01_08_423993	333	59	has	have	VBZ
10_1101-2021_01_08_423993	333	60	granted	grant	VBN
10_1101-2021_01_08_423993	333	61	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	333	62	a	a	DT
10_1101-2021_01_08_423993	333	63	license	license	NN
10_1101-2021_01_08_423993	333	64	to	to	TO
10_1101-2021_01_08_423993	333	65	display	display	VB
10_1101-2021_01_08_423993	333	66	the	the	DT
10_1101-2021_01_08_423993	333	67	preprint	preprint	NN
10_1101-2021_01_08_423993	333	68	in	in	IN
10_1101-2021_01_08_423993	333	69	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	333	70	.	.	.
10_1101-2021_01_08_423993	334	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	334	2	is	be	VBZ
10_1101-2021_01_08_423993	334	3	The	the	DT
10_1101-2021_01_08_423993	334	4	copyright	copyright	NN
10_1101-2021_01_08_423993	334	5	holder	holder	NN
10_1101-2021_01_08_423993	334	6	for	for	IN
10_1101-2021_01_08_423993	334	7	this	this	DT
10_1101-2021_01_08_423993	334	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	334	9	version	version	NN
10_1101-2021_01_08_423993	334	10	posted	post	VBD
10_1101-2021_01_08_423993	334	11	January	January	NNP
10_1101-2021_01_08_423993	334	12	8	8	CD
10_1101-2021_01_08_423993	334	13	,	,	,
10_1101-2021_01_08_423993	334	14	2021	2021	CD
10_1101-2021_01_08_423993	334	15	.	.	.
10_1101-2021_01_08_423993	334	16	;	;	:
10_1101-2021_01_08_423993	334	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	334	18	:	:	:
10_1101-2021_01_08_423993	334	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	334	20	preprint	preprint	NN
10_1101-2021_01_08_423993	334	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	NN
10_1101-2021_01_08_423993	334	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	334	23	site	site	NN
10_1101-2021_01_08_423993	334	24	depending	depend	VBG
10_1101-2021_01_08_423993	334	25	on	on	IN
10_1101-2021_01_08_423993	334	26	the	the	DT
10_1101-2021_01_08_423993	334	27	how	how	WRB
10_1101-2021_01_08_423993	334	28	the	the	DT
10_1101-2021_01_08_423993	334	29	protein	protein	NN
10_1101-2021_01_08_423993	334	30	was	be	VBD
10_1101-2021_01_08_423993	334	31	purified	purify	VBN
10_1101-2021_01_08_423993	334	32	(	(	-LRB-
10_1101-2021_01_08_423993	334	33	PDB	PDB	NNP
10_1101-2021_01_08_423993	334	34	:	:	:
10_1101-2021_01_08_423993	334	35	6TT5	6tt5	LS
10_1101-2021_01_08_423993	334	36	)	)	-RRB-
10_1101-2021_01_08_423993	334	37	.	.	.
10_1101-2021_01_08_423993	335	1	Neither	neither	CC
10_1101-2021_01_08_423993	335	2	the	the	DT
10_1101-2021_01_08_423993	335	3	presence	presence	NN
10_1101-2021_01_08_423993	335	4	of	of	IN
10_1101-2021_01_08_423993	335	5	Ni	Ni	NNP
10_1101-2021_01_08_423993	335	6	ion	ion	NN
10_1101-2021_01_08_423993	335	7	in	in	IN
10_1101-2021_01_08_423993	335	8	the	the	DT
10_1101-2021_01_08_423993	335	9	active	active	JJ
10_1101-2021_01_08_423993	335	10	site	site	NN
10_1101-2021_01_08_423993	335	11	,	,	,
10_1101-2021_01_08_423993	335	12	nor	nor	CC
10_1101-2021_01_08_423993	335	13	the	the	DT
10_1101-2021_01_08_423993	335	14	truncation	truncation	NN
10_1101-2021_01_08_423993	335	15	of	of	IN
10_1101-2021_01_08_423993	335	16	the	the	DT
10_1101-2021_01_08_423993	335	17	C	c	NN
10_1101-2021_01_08_423993	335	18	-	-	HYPH
10_1101-2021_01_08_423993	335	19	terminal	terminal	NN
10_1101-2021_01_08_423993	335	20	tail	tail	NN
10_1101-2021_01_08_423993	335	21	appear	appear	VBP
10_1101-2021_01_08_423993	335	22	to	to	TO
10_1101-2021_01_08_423993	335	23	inhibit	inhibit	VB
10_1101-2021_01_08_423993	335	24	,	,	,
10_1101-2021_01_08_423993	335	25	at	at	IN
10_1101-2021_01_08_423993	335	26	least	least	JJS
10_1101-2021_01_08_423993	335	27	substantially	substantially	RB
10_1101-2021_01_08_423993	335	28	,	,	,
10_1101-2021_01_08_423993	335	29	the	the	DT
10_1101-2021_01_08_423993	335	30	activity	activity	NN
10_1101-2021_01_08_423993	335	31	of	of	IN
10_1101-2021_01_08_423993	335	32	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	335	33	.	.	.
10_1101-2021_01_08_423993	336	1	Thus	thus	RB
10_1101-2021_01_08_423993	336	2	,	,	,
10_1101-2021_01_08_423993	336	3	using	use	VBG
10_1101-2021_01_08_423993	336	4	radio	radio	NN
10_1101-2021_01_08_423993	336	5	-	-	HYPH
10_1101-2021_01_08_423993	336	6	labelled	label	VBN
10_1101-2021_01_08_423993	336	7	gel	gel	NN
10_1101-2021_01_08_423993	336	8	-	-	HYPH
10_1101-2021_01_08_423993	336	9	based	base	VBN
10_1101-2021_01_08_423993	336	10	nuclease	nuclease	NNP
10_1101-2021_01_08_423993	336	11	assays	assays	RB
10_1101-2021_01_08_423993	336	12	,	,	,
10_1101-2021_01_08_423993	336	13	we	-PRON-	PRP
10_1101-2021_01_08_423993	336	14	showed	show	VBD
10_1101-2021_01_08_423993	336	15	that	that	IN
10_1101-2021_01_08_423993	336	16	the	the	DT
10_1101-2021_01_08_423993	336	17	truncated	truncated	JJ
10_1101-2021_01_08_423993	336	18	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	336	19	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	336	20	domain	domain	NN
10_1101-2021_01_08_423993	336	21	(	(	-LRB-
10_1101-2021_01_08_423993	336	22	aa	aa	NNP
10_1101-2021_01_08_423993	336	23	1–361	1–361	CD
10_1101-2021_01_08_423993	336	24	)	)	-RRB-
10_1101-2021_01_08_423993	336	25	with	with	IN
10_1101-2021_01_08_423993	336	26	either	either	DT
10_1101-2021_01_08_423993	336	27	Zn	Zn	NNP
10_1101-2021_01_08_423993	336	28	or	or	CC
10_1101-2021_01_08_423993	336	29	Ni	Ni	NNP
10_1101-2021_01_08_423993	336	30	ions	ion	NNS
10_1101-2021_01_08_423993	336	31	in	in	IN
10_1101-2021_01_08_423993	336	32	the	the	DT
10_1101-2021_01_08_423993	336	33	active	active	JJ
10_1101-2021_01_08_423993	336	34	site	site	NN
10_1101-2021_01_08_423993	336	35	(	(	-LRB-
10_1101-2021_01_08_423993	336	36	as	as	IN
10_1101-2021_01_08_423993	336	37	observed	observe	VBN
10_1101-2021_01_08_423993	336	38	crystallographically	crystallographically	RB
10_1101-2021_01_08_423993	336	39	in	in	IN
10_1101-2021_01_08_423993	336	40	the	the	DT
10_1101-2021_01_08_423993	336	41	same	same	JJ
10_1101-2021_01_08_423993	336	42	preparations	preparation	NNS
10_1101-2021_01_08_423993	336	43	)	)	-RRB-
10_1101-2021_01_08_423993	336	44	have	have	VBP
10_1101-2021_01_08_423993	336	45	similar	similar	JJ
10_1101-2021_01_08_423993	336	46	activity	activity	NN
10_1101-2021_01_08_423993	336	47	with	with	IN
10_1101-2021_01_08_423993	336	48	the	the	DT
10_1101-2021_01_08_423993	336	49	full	full	JJ
10_1101-2021_01_08_423993	336	50	-	-	HYPH
10_1101-2021_01_08_423993	336	51	length	length	NN
10_1101-2021_01_08_423993	336	52	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	336	53	construct	construct	NN
10_1101-2021_01_08_423993	336	54	(	(	-LRB-
10_1101-2021_01_08_423993	336	55	aa	aa	NNP
10_1101-2021_01_08_423993	336	56	1-	1-	NNP
10_1101-2021_01_08_423993	336	57	693	693	CD
10_1101-2021_01_08_423993	336	58	)	)	-RRB-
10_1101-2021_01_08_423993	336	59	.	.	.
10_1101-2021_01_08_423993	337	1	Therefore	therefore	RB
10_1101-2021_01_08_423993	337	2	,	,	,
10_1101-2021_01_08_423993	337	3	it	-PRON-	PRP
10_1101-2021_01_08_423993	337	4	seems	seem	VBZ
10_1101-2021_01_08_423993	337	5	likely	likely	JJ
10_1101-2021_01_08_423993	337	6	that	that	IN
10_1101-2021_01_08_423993	337	7	nickel	nickel	NN
10_1101-2021_01_08_423993	337	8	ions	ion	NNS
10_1101-2021_01_08_423993	337	9	are	be	VBP
10_1101-2021_01_08_423993	337	10	able	able	JJ
10_1101-2021_01_08_423993	337	11	to	to	TO
10_1101-2021_01_08_423993	337	12	replace	replace	VB
10_1101-2021_01_08_423993	337	13	zinc	zinc	NN
10_1101-2021_01_08_423993	337	14	ions	ion	NNS
10_1101-2021_01_08_423993	337	15	in	in	IN
10_1101-2021_01_08_423993	337	16	solution	solution	NN
10_1101-2021_01_08_423993	337	17	,	,	,
10_1101-2021_01_08_423993	337	18	but	but	CC
10_1101-2021_01_08_423993	337	19	catalysis	catalysis	NN
10_1101-2021_01_08_423993	337	20	of	of	IN
10_1101-2021_01_08_423993	337	21	MBL	MBL	NNP
10_1101-2021_01_08_423993	337	22	fold	fold	VB
10_1101-2021_01_08_423993	337	23	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	337	24	,	,	,
10_1101-2021_01_08_423993	337	25	including	include	VBG
10_1101-2021_01_08_423993	337	26	hydrolytic	hydrolytic	JJ
10_1101-2021_01_08_423993	337	27	reactions	reaction	NNS
10_1101-2021_01_08_423993	337	28	,	,	,
10_1101-2021_01_08_423993	337	29	with	with	IN
10_1101-2021_01_08_423993	337	30	metal	metal	NN
10_1101-2021_01_08_423993	337	31	ions	ion	NNS
10_1101-2021_01_08_423993	337	32	other	other	JJ
10_1101-2021_01_08_423993	337	33	than	than	IN
10_1101-2021_01_08_423993	337	34	zinc	zinc	NN
10_1101-2021_01_08_423993	337	35	is	be	VBZ
10_1101-2021_01_08_423993	337	36	well	well	RB
10_1101-2021_01_08_423993	337	37	-	-	HYPH
10_1101-2021_01_08_423993	337	38	precedented	precedente	VBN
10_1101-2021_01_08_423993	337	39	[	[	-LRB-
10_1101-2021_01_08_423993	337	40	67,75	67,75	CD
10_1101-2021_01_08_423993	337	41	]	]	-RRB-
10_1101-2021_01_08_423993	337	42	We	-PRON-	PRP
10_1101-2021_01_08_423993	337	43	also	also	RB
10_1101-2021_01_08_423993	337	44	solved	solve	VBD
10_1101-2021_01_08_423993	337	45	structures	structure	NNS
10_1101-2021_01_08_423993	337	46	of	of	IN
10_1101-2021_01_08_423993	337	47	three	three	CD
10_1101-2021_01_08_423993	337	48	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	337	49	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	337	50	mutants	mutant	NNS
10_1101-2021_01_08_423993	337	51	;	;	:
10_1101-2021_01_08_423993	337	52	D37A	d37a	UH
10_1101-2021_01_08_423993	337	53	,	,	,
10_1101-2021_01_08_423993	337	54	H33A	H33A	NNP
10_1101-2021_01_08_423993	337	55	,	,	,
10_1101-2021_01_08_423993	337	56	and	and	CC
10_1101-2021_01_08_423993	337	57	an	an	DT
10_1101-2021_01_08_423993	337	58	Omenn	Omenn	NNP
10_1101-2021_01_08_423993	337	59	syndrome	syndrome	NN
10_1101-2021_01_08_423993	337	60	patient	patient	NN
10_1101-2021_01_08_423993	337	61	mutation	mutation	NN
10_1101-2021_01_08_423993	337	62	,	,	,
10_1101-2021_01_08_423993	337	63	H35D.	h35d.	ADD
10_1101-2021_01_08_423993	338	1	Using	use	VBG
10_1101-2021_01_08_423993	338	2	gel	gel	NN
10_1101-2021_01_08_423993	338	3	-	-	HYPH
10_1101-2021_01_08_423993	338	4	based	base	VBN
10_1101-2021_01_08_423993	338	5	nuclease	nuclease	NNP
10_1101-2021_01_08_423993	338	6	assays	assays	RB
10_1101-2021_01_08_423993	338	7	,	,	,
10_1101-2021_01_08_423993	338	8	we	-PRON-	PRP
10_1101-2021_01_08_423993	338	9	showed	show	VBD
10_1101-2021_01_08_423993	338	10	that	that	IN
10_1101-2021_01_08_423993	338	11	these	these	DT
10_1101-2021_01_08_423993	338	12	variants	variant	NNS
10_1101-2021_01_08_423993	338	13	are	be	VBP
10_1101-2021_01_08_423993	338	14	biochemically	biochemically	RB
10_1101-2021_01_08_423993	338	15	inactive	inactive	JJ
10_1101-2021_01_08_423993	338	16	.	.	.
10_1101-2021_01_08_423993	339	1	Overall	overall	RB
10_1101-2021_01_08_423993	339	2	,	,	,
10_1101-2021_01_08_423993	339	3	the	the	DT
10_1101-2021_01_08_423993	339	4	three	three	CD
10_1101-2021_01_08_423993	339	5	variant	variant	JJ
10_1101-2021_01_08_423993	339	6	structures	structure	NNS
10_1101-2021_01_08_423993	339	7	are	be	VBP
10_1101-2021_01_08_423993	339	8	similar	similar	JJ
10_1101-2021_01_08_423993	339	9	to	to	IN
10_1101-2021_01_08_423993	339	10	the	the	DT
10_1101-2021_01_08_423993	339	11	WT	WT	NNP
10_1101-2021_01_08_423993	339	12	structure	structure	NN
10_1101-2021_01_08_423993	339	13	,	,	,
10_1101-2021_01_08_423993	339	14	even	even	RB
10_1101-2021_01_08_423993	339	15	though	though	IN
10_1101-2021_01_08_423993	339	16	H33A	H33A	NNP
10_1101-2021_01_08_423993	339	17	and	and	CC
10_1101-2021_01_08_423993	339	18	H35D	H35D	NNP
10_1101-2021_01_08_423993	339	19	entirely	entirely	RB
10_1101-2021_01_08_423993	339	20	lack	lack	VBP
10_1101-2021_01_08_423993	339	21	any	any	DT
10_1101-2021_01_08_423993	339	22	metal	metal	NN
10_1101-2021_01_08_423993	339	23	ions	ion	NNS
10_1101-2021_01_08_423993	339	24	in	in	IN
10_1101-2021_01_08_423993	339	25	the	the	DT
10_1101-2021_01_08_423993	339	26	active	active	JJ
10_1101-2021_01_08_423993	339	27	site	site	NN
10_1101-2021_01_08_423993	339	28	,	,	,
10_1101-2021_01_08_423993	339	29	although	although	IN
10_1101-2021_01_08_423993	339	30	zinc	zinc	NN
10_1101-2021_01_08_423993	339	31	was	be	VBD
10_1101-2021_01_08_423993	339	32	present	present	JJ
10_1101-2021_01_08_423993	339	33	in	in	IN
10_1101-2021_01_08_423993	339	34	the	the	DT
10_1101-2021_01_08_423993	339	35	zinc	zinc	NN
10_1101-2021_01_08_423993	339	36	finger	finger	NN
10_1101-2021_01_08_423993	339	37	.	.	.
10_1101-2021_01_08_423993	340	1	Mutation	mutation	NN
10_1101-2021_01_08_423993	340	2	of	of	IN
10_1101-2021_01_08_423993	340	3	Asp37	Asp37	NNP
10_1101-2021_01_08_423993	340	4	to	to	TO
10_1101-2021_01_08_423993	340	5	alanine	alanine	VB
10_1101-2021_01_08_423993	340	6	results	result	NNS
10_1101-2021_01_08_423993	340	7	in	in	IN
10_1101-2021_01_08_423993	340	8	the	the	DT
10_1101-2021_01_08_423993	340	9	loss	loss	NN
10_1101-2021_01_08_423993	340	10	of	of	IN
10_1101-2021_01_08_423993	340	11	the	the	DT
10_1101-2021_01_08_423993	340	12	second	second	JJ
10_1101-2021_01_08_423993	340	13	metal	metal	NN
10_1101-2021_01_08_423993	340	14	in	in	IN
10_1101-2021_01_08_423993	340	15	the	the	DT
10_1101-2021_01_08_423993	340	16	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	340	17	site	site	NN
10_1101-2021_01_08_423993	340	18	,	,	,
10_1101-2021_01_08_423993	340	19	likely	likely	RB
10_1101-2021_01_08_423993	340	20	explaining	explain	VBG
10_1101-2021_01_08_423993	340	21	the	the	DT
10_1101-2021_01_08_423993	340	22	loss	loss	NN
10_1101-2021_01_08_423993	340	23	of	of	IN
10_1101-2021_01_08_423993	340	24	activity	activity	NN
10_1101-2021_01_08_423993	340	25	,	,	,
10_1101-2021_01_08_423993	340	26	although	although	IN
10_1101-2021_01_08_423993	340	27	the	the	DT
10_1101-2021_01_08_423993	340	28	first	first	JJ
10_1101-2021_01_08_423993	340	29	metal	metal	NN
10_1101-2021_01_08_423993	340	30	ion	ion	NN
10_1101-2021_01_08_423993	340	31	is	be	VBZ
10_1101-2021_01_08_423993	340	32	still	still	RB
10_1101-2021_01_08_423993	340	33	present	present	JJ
10_1101-2021_01_08_423993	340	34	.	.	.
10_1101-2021_01_08_423993	341	1	Note	note	VB
10_1101-2021_01_08_423993	341	2	that	that	IN
10_1101-2021_01_08_423993	341	3	some	some	DT
10_1101-2021_01_08_423993	341	4	MBL	mbl	NN
10_1101-2021_01_08_423993	341	5	fold	fold	VBP
10_1101-2021_01_08_423993	341	6	hydrolases	hydrolase	NNS
10_1101-2021_01_08_423993	341	7	uses	use	VBZ
10_1101-2021_01_08_423993	341	8	two	two	CD
10_1101-2021_01_08_423993	341	9	metal	metal	NN
10_1101-2021_01_08_423993	341	10	ions	ion	NNS
10_1101-2021_01_08_423993	341	11	(	(	-LRB-
10_1101-2021_01_08_423993	341	12	e.g	e.g	NNP
10_1101-2021_01_08_423993	341	13	.	.	NNP
10_1101-2021_01_08_423993	341	14	,B1	,B1	NFP
10_1101-2021_01_08_423993	341	15	and	and	CC
10_1101-2021_01_08_423993	341	16	B3	b3	NN
10_1101-2021_01_08_423993	341	17	subfamilies	subfamily	NNS
10_1101-2021_01_08_423993	341	18	of	of	IN
10_1101-2021_01_08_423993	341	19	the	the	DT
10_1101-2021_01_08_423993	341	20	true	true	JJ
10_1101-2021_01_08_423993	341	21	MBLs	mbl	NNS
10_1101-2021_01_08_423993	341	22	and	and	CC
10_1101-2021_01_08_423993	341	23	RNase	rnase	UH
10_1101-2021_01_08_423993	341	24	J1	j1	NN
10_1101-2021_01_08_423993	341	25	from	from	IN
10_1101-2021_01_08_423993	341	26	Bacillus	bacillus	NN
10_1101-2021_01_08_423993	341	27	subtilis	subtili	NNS
10_1101-2021_01_08_423993	341	28	)	)	-RRB-
10_1101-2021_01_08_423993	341	29	(	(	-LRB-
10_1101-2021_01_08_423993	341	30	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	341	31	.	.	.
10_1101-2021_01_08_423993	342	1	Figure	Figure	NNP
10_1101-2021_01_08_423993	342	2	13A	13A	NNP
10_1101-2021_01_08_423993	342	3	and	and	CC
10_1101-2021_01_08_423993	342	4	C	C	NNP
10_1101-2021_01_08_423993	342	5	)	)	-RRB-
10_1101-2021_01_08_423993	342	6	[	[	-LRB-
10_1101-2021_01_08_423993	342	7	67,76	67,76	CD
10_1101-2021_01_08_423993	342	8	]	]	-RRB-
10_1101-2021_01_08_423993	342	9	whereas	whereas	IN
10_1101-2021_01_08_423993	342	10	others	other	NNS
10_1101-2021_01_08_423993	342	11	,	,	,
10_1101-2021_01_08_423993	342	12	sometimes	sometimes	RB
10_1101-2021_01_08_423993	342	13	with	with	IN
10_1101-2021_01_08_423993	342	14	apparently	apparently	RB
10_1101-2021_01_08_423993	342	15	very	very	RB
10_1101-2021_01_08_423993	342	16	similar	similar	JJ
10_1101-2021_01_08_423993	342	17	active	active	JJ
10_1101-2021_01_08_423993	342	18	sites	site	NNS
10_1101-2021_01_08_423993	342	19	,	,	,
10_1101-2021_01_08_423993	342	20	only	only	RB
10_1101-2021_01_08_423993	342	21	use	use	VB
10_1101-2021_01_08_423993	342	22	one	one	CD
10_1101-2021_01_08_423993	342	23	metal	metal	NN
10_1101-2021_01_08_423993	342	24	ion	ion	NN
10_1101-2021_01_08_423993	342	25	(	(	-LRB-
10_1101-2021_01_08_423993	342	26	e.g.	e.g.	RB
10_1101-2021_01_08_423993	343	1	the	the	DT
10_1101-2021_01_08_423993	343	2	B2	b2	NN
10_1101-2021_01_08_423993	343	3	subfamily	subfamily	RB
10_1101-2021_01_08_423993	343	4	of	of	IN
10_1101-2021_01_08_423993	343	5	the	the	DT
10_1101-2021_01_08_423993	343	6	true	true	JJ
10_1101-2021_01_08_423993	343	7	MBLs	mbl	NNS
10_1101-2021_01_08_423993	343	8	and	and	CC
10_1101-2021_01_08_423993	343	9	RNase	rnase	VB
10_1101-2021_01_08_423993	343	10	J	J	NNP
10_1101-2021_01_08_423993	343	11	from	from	IN
10_1101-2021_01_08_423993	343	12	Staphylococcus	Staphylococcus	NNP
10_1101-2021_01_08_423993	343	13	epidermis	epidermis	NN
10_1101-2021_01_08_423993	343	14	)	)	-RRB-
10_1101-2021_01_08_423993	343	15	[	[	-LRB-
10_1101-2021_01_08_423993	343	16	67,77](Suppl	67,77](suppl	CD
10_1101-2021_01_08_423993	343	17	.	.	.
10_1101-2021_01_08_423993	344	1	Figure	figure	NN
10_1101-2021_01_08_423993	344	2	13B	13B	NNP
10_1101-2021_01_08_423993	344	3	and	and	CC
10_1101-2021_01_08_423993	344	4	D	d	NN
10_1101-2021_01_08_423993	344	5	)	)	-RRB-
10_1101-2021_01_08_423993	344	6	.	.	.
10_1101-2021_01_08_423993	345	1	Thus	thus	RB
10_1101-2021_01_08_423993	345	2	,	,	,
10_1101-2021_01_08_423993	345	3	whilst	whilst	IN
10_1101-2021_01_08_423993	345	4	our	-PRON-	PRP$
10_1101-2021_01_08_423993	345	5	results	result	NNS
10_1101-2021_01_08_423993	345	6	support	support	VBP
10_1101-2021_01_08_423993	345	7	the	the	DT
10_1101-2021_01_08_423993	345	8	importance	importance	NN
10_1101-2021_01_08_423993	345	9	of	of	IN
10_1101-2021_01_08_423993	345	10	having	have	VBG
10_1101-2021_01_08_423993	345	11	both	both	DT
10_1101-2021_01_08_423993	345	12	metals	metal	NNS
10_1101-2021_01_08_423993	345	13	for	for	IN
10_1101-2021_01_08_423993	345	14	the	the	DT
10_1101-2021_01_08_423993	345	15	nuclease	nuclease	NN
10_1101-2021_01_08_423993	345	16	activity	activity	NN
10_1101-2021_01_08_423993	345	17	by	by	IN
10_1101-2021_01_08_423993	345	18	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	345	19	,	,	,
10_1101-2021_01_08_423993	345	20	subtle	subtle	JJ
10_1101-2021_01_08_423993	345	21	features	feature	NNS
10_1101-2021_01_08_423993	345	22	can	can	MD
10_1101-2021_01_08_423993	345	23	influence	influence	VB
10_1101-2021_01_08_423993	345	24	MBL	MBL	NNP
10_1101-2021_01_08_423993	345	25	fold	fold	VB
10_1101-2021_01_08_423993	345	26	enzyme	enzyme	NNS
10_1101-2021_01_08_423993	345	27	activity	activity	NN
10_1101-2021_01_08_423993	345	28	[	[	-LRB-
10_1101-2021_01_08_423993	345	29	67,74	67,74	CD
10_1101-2021_01_08_423993	345	30	]	]	-RRB-
10_1101-2021_01_08_423993	345	31	.	.	.
10_1101-2021_01_08_423993	346	1	Following	follow	VBG
10_1101-2021_01_08_423993	346	2	re	re	NN
10_1101-2021_01_08_423993	346	3	-	-	NN
10_1101-2021_01_08_423993	346	4	analysis	analysis	NN
10_1101-2021_01_08_423993	346	5	of	of	IN
10_1101-2021_01_08_423993	346	6	the	the	DT
10_1101-2021_01_08_423993	346	7	Karim	Karim	NNP
10_1101-2021_01_08_423993	346	8	et.al	et.al	NNS
10_1101-2021_01_08_423993	346	9	structure	structure	NN
10_1101-2021_01_08_423993	346	10	(	(	-LRB-
10_1101-2021_01_08_423993	346	11	PDB	PDB	NNP
10_1101-2021_01_08_423993	346	12	code	code	NN
10_1101-2021_01_08_423993	346	13	6WO0	6wo0	CD
10_1101-2021_01_08_423993	346	14	)	)	-RRB-
10_1101-2021_01_08_423993	346	15	,	,	,
10_1101-2021_01_08_423993	346	16	we	-PRON-	PRP
10_1101-2021_01_08_423993	346	17	were	be	VBD
10_1101-2021_01_08_423993	346	18	able	able	JJ
10_1101-2021_01_08_423993	346	19	to	to	TO
10_1101-2021_01_08_423993	346	20	generate	generate	VB
10_1101-2021_01_08_423993	346	21	a	a	DT
10_1101-2021_01_08_423993	346	22	model	model	NN
10_1101-2021_01_08_423993	346	23	of	of	IN
10_1101-2021_01_08_423993	346	24	a	a	DT
10_1101-2021_01_08_423993	346	25	DNA	dna	NN
10_1101-2021_01_08_423993	346	26	overhang	overhang	NN
10_1101-2021_01_08_423993	346	27	I.	i.	NN
10_1101-2021_01_08_423993	346	28	complex	complex	NN
10_1101-2021_01_08_423993	346	29	with	with	IN
10_1101-2021_01_08_423993	346	30	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	346	31	that	that	WDT
10_1101-2021_01_08_423993	346	32	informs	inform	VBZ
10_1101-2021_01_08_423993	346	33	on	on	IN
10_1101-2021_01_08_423993	346	34	the	the	DT
10_1101-2021_01_08_423993	346	35	substrate	substrate	NN
10_1101-2021_01_08_423993	346	36	binding	binding	NN
10_1101-2021_01_08_423993	346	37	mode	mode	NN
10_1101-2021_01_08_423993	346	38	.	.	.
10_1101-2021_01_08_423993	347	1	Our	-PRON-	PRP$
10_1101-2021_01_08_423993	347	2	model	model	NN
10_1101-2021_01_08_423993	347	3	shows	show	VBZ
10_1101-2021_01_08_423993	347	4	that	that	IN
10_1101-2021_01_08_423993	347	5	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	347	6	interacts	interact	VBZ
10_1101-2021_01_08_423993	347	7	with	with	IN
10_1101-2021_01_08_423993	347	8	the	the	DT
10_1101-2021_01_08_423993	347	9	DNA	DNA	NNP
10_1101-2021_01_08_423993	347	10	substrate	substrate	NN
10_1101-2021_01_08_423993	347	11	in	in	IN
10_1101-2021_01_08_423993	347	12	the	the	DT
10_1101-2021_01_08_423993	347	13	interface	interface	NN
10_1101-2021_01_08_423993	347	14	between	between	IN
10_1101-2021_01_08_423993	347	15	the	the	DT
10_1101-2021_01_08_423993	347	16	MBL	MBL	NNP
10_1101-2021_01_08_423993	347	17	and	and	CC
10_1101-2021_01_08_423993	347	18	the	the	DT
10_1101-2021_01_08_423993	347	19	β	β	NNP
10_1101-2021_01_08_423993	347	20	-	-	HYPH
10_1101-2021_01_08_423993	347	21	CASP	CASP	NNP
10_1101-2021_01_08_423993	347	22	domains	domain	NNS
10_1101-2021_01_08_423993	347	23	.	.	.
10_1101-2021_01_08_423993	348	1	This	this	DT
10_1101-2021_01_08_423993	348	2	interaction	interaction	NN
10_1101-2021_01_08_423993	348	3	is	be	VBZ
10_1101-2021_01_08_423993	348	4	mediated	mediate	VBN
10_1101-2021_01_08_423993	348	5	through	through	IN
10_1101-2021_01_08_423993	348	6	the	the	DT
10_1101-2021_01_08_423993	348	7	combination	combination	NN
10_1101-2021_01_08_423993	348	8	of	of	IN
10_1101-2021_01_08_423993	348	9	polar	polar	JJ
10_1101-2021_01_08_423993	348	10	or	or	CC
10_1101-2021_01_08_423993	348	11	positive	positive	JJ
10_1101-2021_01_08_423993	348	12	residues	residue	NNS
10_1101-2021_01_08_423993	348	13	and	and	CC
10_1101-2021_01_08_423993	348	14	aromatic	aromatic	JJ
10_1101-2021_01_08_423993	348	15	residues	residue	NNS
10_1101-2021_01_08_423993	348	16	of	of	IN
10_1101-2021_01_08_423993	348	17	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	348	18	and	and	CC
10_1101-2021_01_08_423993	348	19	the	the	DT
10_1101-2021_01_08_423993	348	20	DNA	dna	NN
10_1101-2021_01_08_423993	348	21	substrate	substrate	NN
10_1101-2021_01_08_423993	348	22	(	(	-LRB-
10_1101-2021_01_08_423993	348	23	Figure	figure	NN
10_1101-2021_01_08_423993	348	24	6	6	CD
10_1101-2021_01_08_423993	348	25	)	)	-RRB-
10_1101-2021_01_08_423993	348	26	.	.	.
10_1101-2021_01_08_423993	349	1	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	349	2	is	be	VBZ
10_1101-2021_01_08_423993	349	3	the	the	DT
10_1101-2021_01_08_423993	349	4	only	only	JJ
10_1101-2021_01_08_423993	349	5	identified	identify	VBN
10_1101-2021_01_08_423993	349	6	MBL	MBL	NNP
10_1101-2021_01_08_423993	349	7	/	/	SYM
10_1101-2021_01_08_423993	349	8	β	β	NNP
10_1101-2021_01_08_423993	349	9	-	-	HYPH
10_1101-2021_01_08_423993	349	10	CASP	CASP	NNP
10_1101-2021_01_08_423993	349	11	DNA	dna	NN
10_1101-2021_01_08_423993	349	12	processing	processing	NN
10_1101-2021_01_08_423993	349	13	enzyme	enzyme	NNS
10_1101-2021_01_08_423993	349	14	that	that	WDT
10_1101-2021_01_08_423993	349	15	possesses	possess	VBZ
10_1101-2021_01_08_423993	349	16	substantive	substantive	JJ
10_1101-2021_01_08_423993	349	17	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	349	18	activity	activity	NN
10_1101-2021_01_08_423993	349	19	.	.	.
10_1101-2021_01_08_423993	350	1	By	by	IN
10_1101-2021_01_08_423993	350	2	contrast	contrast	NN
10_1101-2021_01_08_423993	350	3	both	both	DT
10_1101-2021_01_08_423993	350	4	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	350	5	and	and	CC
10_1101-2021_01_08_423993	350	6	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	350	7	/	/	SYM
10_1101-2021_01_08_423993	350	8	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	350	9	are	be	VBP
10_1101-2021_01_08_423993	350	10	strictly	strictly	RB
10_1101-2021_01_08_423993	350	11	phosphate	phosphate	JJ
10_1101-2021_01_08_423993	350	12	exonucleases	exonuclease	NNS
10_1101-2021_01_08_423993	350	13	[	[	-LRB-
10_1101-2021_01_08_423993	350	14	3,9,15	3,9,15	CD
10_1101-2021_01_08_423993	350	15	]	]	-RRB-
10_1101-2021_01_08_423993	350	16	.	.	.
10_1101-2021_01_08_423993	351	1	The	the	DT
10_1101-2021_01_08_423993	351	2	recent	recent	JJ
10_1101-2021_01_08_423993	351	3	structure	structure	NN
10_1101-2021_01_08_423993	351	4	of	of	IN
10_1101-2021_01_08_423993	351	5	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	351	6	/	/	SYM
10_1101-2021_01_08_423993	351	7	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	351	8	in	in	IN
10_1101-2021_01_08_423993	351	9	complex	complex	JJ
10_1101-2021_01_08_423993	351	10	with	with	IN
10_1101-2021_01_08_423993	351	11	-	-	HYPH
10_1101-2021_01_08_423993	351	12	׳5	׳5	NN
10_1101-2021_01_08_423993	351	13	two	two	CD
10_1101-2021_01_08_423993	351	14	deoxyadenosine	deoxyadenosine	NN
10_1101-2021_01_08_423993	351	15	monophosphate	monophosphate	NN
10_1101-2021_01_08_423993	351	16	nucleotides	nucleotide	NNS
10_1101-2021_01_08_423993	351	17	(	(	-LRB-
10_1101-2021_01_08_423993	351	18	PDB	PDB	NNP
10_1101-2021_01_08_423993	351	19	code	code	NN
10_1101-2021_01_08_423993	351	20	:	:	:
10_1101-2021_01_08_423993	351	21	7A1F	7a1f	CD
10_1101-2021_01_08_423993	351	22	)	)	-RRB-
10_1101-2021_01_08_423993	351	23	reported	report	VBN
10_1101-2021_01_08_423993	351	24	by	by	IN
10_1101-2021_01_08_423993	351	25	Baddock	Baddock	NNP
10_1101-2021_01_08_423993	351	26	et	et	NNP
10_1101-2021_01_08_423993	351	27	.	.	.
10_1101-2021_01_08_423993	352	1	al	al	NNP
10_1101-2021_01_08_423993	352	2	.	.	.
10_1101-2021_01_08_423993	353	1	2020	2020	CD
10_1101-2021_01_08_423993	353	2	,	,	,
10_1101-2021_01_08_423993	353	3	reveals	reveal	VBZ
10_1101-2021_01_08_423993	353	4	a	a	DT
10_1101-2021_01_08_423993	353	5	cluster	cluster	NN
10_1101-2021_01_08_423993	353	6	of	of	IN
10_1101-2021_01_08_423993	353	7	residues	residue	NNS
10_1101-2021_01_08_423993	353	8	that	that	WDT
10_1101-2021_01_08_423993	353	9	form	form	VBP
10_1101-2021_01_08_423993	353	10	a	a	DT
10_1101-2021_01_08_423993	353	11	5	5	CD
10_1101-2021_01_08_423993	353	12	׳	׳	NNP
10_1101-2021_01_08_423993	353	13	-	-	HYPH
10_1101-2021_01_08_423993	353	14	phosphate	phosphate	NN
10_1101-2021_01_08_423993	353	15	binding	binding	NN
10_1101-2021_01_08_423993	353	16	pocket	pocket	NN
10_1101-2021_01_08_423993	353	17	,	,	,
10_1101-2021_01_08_423993	353	18	adjacent	adjacent	JJ
10_1101-2021_01_08_423993	353	19	to	to	IN
10_1101-2021_01_08_423993	353	20	the	the	DT
10_1101-2021_01_08_423993	353	21	metal	metal	NN
10_1101-2021_01_08_423993	353	22	centre	centre	NN
10_1101-2021_01_08_423993	353	23	.	.	.
10_1101-2021_01_08_423993	354	1	Structural	structural	JJ
10_1101-2021_01_08_423993	354	2	sequence	sequence	NN
10_1101-2021_01_08_423993	354	3	alignments	alignment	NNS
10_1101-2021_01_08_423993	354	4	of	of	IN
10_1101-2021_01_08_423993	354	5	the	the	DT
10_1101-2021_01_08_423993	354	6	three	three	CD
10_1101-2021_01_08_423993	354	7	proteins	protein	NNS
10_1101-2021_01_08_423993	354	8	shows	show	VBZ
10_1101-2021_01_08_423993	354	9	that	that	IN
10_1101-2021_01_08_423993	354	10	these	these	DT
10_1101-2021_01_08_423993	354	11	residues	residue	NNS
10_1101-2021_01_08_423993	354	12	are	be	VBP
10_1101-2021_01_08_423993	354	13	highly	highly	RB
10_1101-2021_01_08_423993	354	14	conserved	conserve	VBN
10_1101-2021_01_08_423993	354	15	in	in	IN
10_1101-2021_01_08_423993	354	16	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	354	17	and	and	CC
10_1101-2021_01_08_423993	354	18	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	354	19	(	(	-LRB-
10_1101-2021_01_08_423993	354	20	Suppl	Suppl	NNP
10_1101-2021_01_08_423993	354	21	.	.	.
10_1101-2021_01_08_423993	355	1	Figure	figure	NN
10_1101-2021_01_08_423993	355	2	1	1	CD
10_1101-2021_01_08_423993	355	3	)	)	-RRB-
10_1101-2021_01_08_423993	355	4	.	.	.
10_1101-2021_01_08_423993	356	1	Apart	apart	RB
10_1101-2021_01_08_423993	356	2	from	from	IN
10_1101-2021_01_08_423993	356	3	Ser	Ser	NNP
10_1101-2021_01_08_423993	356	4	317	317	CD
10_1101-2021_01_08_423993	356	5	,	,	,
10_1101-2021_01_08_423993	356	6	none	none	NN
10_1101-2021_01_08_423993	356	7	of	of	IN
10_1101-2021_01_08_423993	356	8	these	these	DT
10_1101-2021_01_08_423993	356	9	conserved	conserve	VBN
10_1101-2021_01_08_423993	356	10	phosphate	phosphate	NN
10_1101-2021_01_08_423993	356	11	binding	binding	NN
10_1101-2021_01_08_423993	356	12	pocket	pocket	NN
10_1101-2021_01_08_423993	356	13	residues	residue	NNS
10_1101-2021_01_08_423993	356	14	are	be	VBP
10_1101-2021_01_08_423993	356	15	present	present	JJ
10_1101-2021_01_08_423993	356	16	in	in	IN
10_1101-2021_01_08_423993	356	17	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	356	18	.	.	.
10_1101-2021_01_08_423993	357	1	Instead	instead	RB
10_1101-2021_01_08_423993	357	2	,	,	,
10_1101-2021_01_08_423993	357	3	the	the	DT
10_1101-2021_01_08_423993	357	4	pocket	pocket	NN
10_1101-2021_01_08_423993	357	5	is	be	VBZ
10_1101-2021_01_08_423993	357	6	partially	partially	RB
10_1101-2021_01_08_423993	357	7	occupied	occupy	VBN
10_1101-2021_01_08_423993	357	8	by	by	IN
10_1101-2021_01_08_423993	357	9	the	the	DT
10_1101-2021_01_08_423993	357	10	Phe318	phe318	CD
10_1101-2021_01_08_423993	357	11	side	side	NN
10_1101-2021_01_08_423993	357	12	chain	chain	NN
10_1101-2021_01_08_423993	357	13	,	,	,
10_1101-2021_01_08_423993	357	14	which	which	WDT
10_1101-2021_01_08_423993	357	15	is	be	VBZ
10_1101-2021_01_08_423993	357	16	absent	absent	JJ
10_1101-2021_01_08_423993	357	17	in	in	IN
10_1101-2021_01_08_423993	357	18	both	both	DT
10_1101-2021_01_08_423993	357	19	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	357	20	and	and	CC
10_1101-2021_01_08_423993	357	21	SNM1B.	snm1b.	NN
10_1101-2021_01_08_423993	358	1	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	358	2	also	also	RB
10_1101-2021_01_08_423993	358	3	possesses	possess	VBZ
10_1101-2021_01_08_423993	358	4	a	a	DT
10_1101-2021_01_08_423993	358	5	longer	long	JJR
10_1101-2021_01_08_423993	358	6	and	and	CC
10_1101-2021_01_08_423993	358	7	more	more	RBR
10_1101-2021_01_08_423993	358	8	flexible	flexible	JJ
10_1101-2021_01_08_423993	358	9	loop	loop	NN
10_1101-2021_01_08_423993	358	10	connecting	connect	VBG
10_1101-2021_01_08_423993	358	11	β-	β-	NNP
10_1101-2021_01_08_423993	358	12	strands	strand	VBZ
10_1101-2021_01_08_423993	358	13	27	27	CD
10_1101-2021_01_08_423993	358	14	and	and	CC
10_1101-2021_01_08_423993	358	15	28	28	CD
10_1101-2021_01_08_423993	358	16	(	(	-LRB-
10_1101-2021_01_08_423993	358	17	Figure	figure	NN
10_1101-2021_01_08_423993	358	18	6B	6b	NN
10_1101-2021_01_08_423993	358	19	)	)	-RRB-
10_1101-2021_01_08_423993	358	20	,	,	,
10_1101-2021_01_08_423993	358	21	compared	compare	VBN
10_1101-2021_01_08_423993	358	22	to	to	IN
10_1101-2021_01_08_423993	358	23	the	the	DT
10_1101-2021_01_08_423993	358	24	same	same	JJ
10_1101-2021_01_08_423993	358	25	loop	loop	NN
10_1101-2021_01_08_423993	358	26	in	in	IN
10_1101-2021_01_08_423993	358	27	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	358	28	and	and	CC
10_1101-2021_01_08_423993	358	29	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	358	30	that	that	WDT
10_1101-2021_01_08_423993	358	31	make	make	VBP
10_1101-2021_01_08_423993	358	32	.CC	.CC	:
10_1101-2021_01_08_423993	358	33	-	-	:
10_1101-2021_01_08_423993	358	34	BY	by	IN
10_1101-2021_01_08_423993	358	35	4.0	4.0	CD
10_1101-2021_01_08_423993	358	36	International	international	JJ
10_1101-2021_01_08_423993	358	37	licensemade	licensemade	NN
10_1101-2021_01_08_423993	358	38	available	available	JJ
10_1101-2021_01_08_423993	358	39	under	under	IN
10_1101-2021_01_08_423993	358	40	a	a	DT
10_1101-2021_01_08_423993	358	41	(	(	-LRB-
10_1101-2021_01_08_423993	358	42	which	which	WDT
10_1101-2021_01_08_423993	358	43	was	be	VBD
10_1101-2021_01_08_423993	358	44	not	not	RB
10_1101-2021_01_08_423993	358	45	certified	certify	VBN
10_1101-2021_01_08_423993	358	46	by	by	IN
10_1101-2021_01_08_423993	358	47	peer	peer	NN
10_1101-2021_01_08_423993	358	48	review	review	NN
10_1101-2021_01_08_423993	358	49	)	)	-RRB-
10_1101-2021_01_08_423993	358	50	is	be	VBZ
10_1101-2021_01_08_423993	358	51	the	the	DT
10_1101-2021_01_08_423993	358	52	author	author	NN
10_1101-2021_01_08_423993	358	53	/	/	SYM
10_1101-2021_01_08_423993	358	54	funder	funder	NN
10_1101-2021_01_08_423993	358	55	,	,	,
10_1101-2021_01_08_423993	358	56	who	who	WP
10_1101-2021_01_08_423993	358	57	has	have	VBZ
10_1101-2021_01_08_423993	358	58	granted	grant	VBN
10_1101-2021_01_08_423993	358	59	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	358	60	a	a	DT
10_1101-2021_01_08_423993	358	61	license	license	NN
10_1101-2021_01_08_423993	358	62	to	to	TO
10_1101-2021_01_08_423993	358	63	display	display	VB
10_1101-2021_01_08_423993	358	64	the	the	DT
10_1101-2021_01_08_423993	358	65	preprint	preprint	NN
10_1101-2021_01_08_423993	358	66	in	in	IN
10_1101-2021_01_08_423993	358	67	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	358	68	.	.	.
10_1101-2021_01_08_423993	359	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	359	2	is	be	VBZ
10_1101-2021_01_08_423993	359	3	The	the	DT
10_1101-2021_01_08_423993	359	4	copyright	copyright	NN
10_1101-2021_01_08_423993	359	5	holder	holder	NN
10_1101-2021_01_08_423993	359	6	for	for	IN
10_1101-2021_01_08_423993	359	7	this	this	DT
10_1101-2021_01_08_423993	359	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	359	9	version	version	NN
10_1101-2021_01_08_423993	359	10	posted	post	VBD
10_1101-2021_01_08_423993	359	11	January	January	NNP
10_1101-2021_01_08_423993	359	12	8	8	CD
10_1101-2021_01_08_423993	359	13	,	,	,
10_1101-2021_01_08_423993	359	14	2021	2021	CD
10_1101-2021_01_08_423993	359	15	.	.	.
10_1101-2021_01_08_423993	359	16	;	;	:
10_1101-2021_01_08_423993	359	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	359	18	:	:	:
10_1101-2021_01_08_423993	359	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	359	20	preprint	preprint	NN
10_1101-2021_01_08_423993	359	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	359	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	359	23	up	up	RB
10_1101-2021_01_08_423993	359	24	part	part	NN
10_1101-2021_01_08_423993	359	25	of	of	IN
10_1101-2021_01_08_423993	359	26	the	the	DT
10_1101-2021_01_08_423993	359	27	5	5	CD
10_1101-2021_01_08_423993	359	28	׳	׳	NNP
10_1101-2021_01_08_423993	359	29	-	-	HYPH
10_1101-2021_01_08_423993	359	30	phosphate	phosphate	NN
10_1101-2021_01_08_423993	359	31	binding	binding	NN
10_1101-2021_01_08_423993	359	32	pocket	pocket	NN
10_1101-2021_01_08_423993	359	33	.	.	.
10_1101-2021_01_08_423993	360	1	The	the	DT
10_1101-2021_01_08_423993	360	2	flexibility	flexibility	NN
10_1101-2021_01_08_423993	360	3	of	of	IN
10_1101-2021_01_08_423993	360	4	this	this	DT
10_1101-2021_01_08_423993	360	5	loop	loop	NN
10_1101-2021_01_08_423993	360	6	could	could	MD
10_1101-2021_01_08_423993	360	7	enable	enable	VB
10_1101-2021_01_08_423993	360	8	accommodation	accommodation	NN
10_1101-2021_01_08_423993	360	9	with	with	IN
10_1101-2021_01_08_423993	360	10	different	different	JJ
10_1101-2021_01_08_423993	360	11	types	type	NNS
10_1101-2021_01_08_423993	360	12	of	of	IN
10_1101-2021_01_08_423993	360	13	DNA	dna	NN
10_1101-2021_01_08_423993	360	14	structures	structure	NNS
10_1101-2021_01_08_423993	360	15	,	,	,
10_1101-2021_01_08_423993	360	16	such	such	JJ
10_1101-2021_01_08_423993	360	17	as	as	IN
10_1101-2021_01_08_423993	360	18	hairpins	hairpin	NNS
10_1101-2021_01_08_423993	360	19	,	,	,
10_1101-2021_01_08_423993	360	20	and	and	CC
10_1101-2021_01_08_423993	360	21	5	5	CD
10_1101-2021_01_08_423993	360	22	׳	׳	NNP
10_1101-2021_01_08_423993	360	23	-	-	HYPH
10_1101-2021_01_08_423993	360	24	overhangs	overhang	NNS
10_1101-2021_01_08_423993	360	25	.	.	.
10_1101-2021_01_08_423993	361	1	These	these	DT
10_1101-2021_01_08_423993	361	2	differences	difference	NNS
10_1101-2021_01_08_423993	361	3	plausibly	plausibly	RB
10_1101-2021_01_08_423993	361	4	explain	explain	VBP
10_1101-2021_01_08_423993	361	5	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	361	6	’	’	POS
10_1101-2021_01_08_423993	361	7	substrate	substrate	NN
10_1101-2021_01_08_423993	361	8	preferences	preference	NNS
10_1101-2021_01_08_423993	361	9	and	and	CC
10_1101-2021_01_08_423993	361	10	its	-PRON-	PRP$
10_1101-2021_01_08_423993	361	11	primary	primary	JJ
10_1101-2021_01_08_423993	361	12	activity	activity	NN
10_1101-2021_01_08_423993	361	13	as	as	IN
10_1101-2021_01_08_423993	361	14	a	a	DT
10_1101-2021_01_08_423993	361	15	structure	structure	NN
10_1101-2021_01_08_423993	361	16	-	-	HYPH
10_1101-2021_01_08_423993	361	17	selective	selective	JJ
10_1101-2021_01_08_423993	361	18	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	361	19	.	.	.
10_1101-2021_01_08_423993	362	1	Of	of	IN
10_1101-2021_01_08_423993	362	2	the	the	DT
10_1101-2021_01_08_423993	362	3	three	three	CD
10_1101-2021_01_08_423993	362	4	of	of	IN
10_1101-2021_01_08_423993	362	5	the	the	DT
10_1101-2021_01_08_423993	362	6	β	β	NNP
10_1101-2021_01_08_423993	362	7	-	-	HYPH
10_1101-2021_01_08_423993	362	8	lactam	lactam	NNP
10_1101-2021_01_08_423993	362	9	anti	anti	NNP
10_1101-2021_01_08_423993	362	10	bacterial	bacterial	JJ
10_1101-2021_01_08_423993	362	11	compounds	compound	NNS
10_1101-2021_01_08_423993	362	12	previously	previously	RB
10_1101-2021_01_08_423993	362	13	shown	show	VBN
10_1101-2021_01_08_423993	362	14	to	to	TO
10_1101-2021_01_08_423993	362	15	inhibit	inhibit	VB
10_1101-2021_01_08_423993	362	16	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	362	17	[	[	-LRB-
10_1101-2021_01_08_423993	362	18	66	66	CD
10_1101-2021_01_08_423993	362	19	]	]	-RRB-
10_1101-2021_01_08_423993	362	20	,	,	,
10_1101-2021_01_08_423993	362	21	we	-PRON-	PRP
10_1101-2021_01_08_423993	362	22	only	only	RB
10_1101-2021_01_08_423993	362	23	observed	observe	VBD
10_1101-2021_01_08_423993	362	24	inhibition	inhibition	NN
10_1101-2021_01_08_423993	362	25	of	of	IN
10_1101-2021_01_08_423993	362	26	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	362	27	with	with	IN
10_1101-2021_01_08_423993	362	28	ceftriaxone	ceftriaxone	NN
10_1101-2021_01_08_423993	362	29	.	.	.
10_1101-2021_01_08_423993	363	1	Although	although	IN
10_1101-2021_01_08_423993	363	2	the	the	DT
10_1101-2021_01_08_423993	363	3	potency	potency	NN
10_1101-2021_01_08_423993	363	4	of	of	IN
10_1101-2021_01_08_423993	363	5	inhibition	inhibition	NN
10_1101-2021_01_08_423993	363	6	is	be	VBZ
10_1101-2021_01_08_423993	363	7	moderate	moderate	JJ
10_1101-2021_01_08_423993	363	8	(	(	-LRB-
10_1101-2021_01_08_423993	363	9	IC50	IC50	NNP
10_1101-2021_01_08_423993	363	10	65	65	CD
10_1101-2021_01_08_423993	363	11	µM	µM	NNP
10_1101-2021_01_08_423993	363	12	)	)	-RRB-
10_1101-2021_01_08_423993	363	13	,	,	,
10_1101-2021_01_08_423993	363	14	we	-PRON-	PRP
10_1101-2021_01_08_423993	363	15	were	be	VBD
10_1101-2021_01_08_423993	363	16	able	able	JJ
10_1101-2021_01_08_423993	363	17	to	to	TO
10_1101-2021_01_08_423993	363	18	solve	solve	VB
10_1101-2021_01_08_423993	363	19	the	the	DT
10_1101-2021_01_08_423993	363	20	structure	structure	NN
10_1101-2021_01_08_423993	363	21	of	of	IN
10_1101-2021_01_08_423993	363	22	ceftriaxone	ceftriaxone	NN
10_1101-2021_01_08_423993	363	23	in	in	IN
10_1101-2021_01_08_423993	363	24	complex	complex	NN
10_1101-2021_01_08_423993	363	25	with	with	IN
10_1101-2021_01_08_423993	363	26	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	363	27	.	.	.
10_1101-2021_01_08_423993	364	1	Notably	notably	RB
10_1101-2021_01_08_423993	364	2	,	,	,
10_1101-2021_01_08_423993	364	3	ceftriaxone	ceftriaxone	NN
10_1101-2021_01_08_423993	364	4	does	do	VBZ
10_1101-2021_01_08_423993	364	5	not	not	RB
10_1101-2021_01_08_423993	364	6	bind	bind	VB
10_1101-2021_01_08_423993	364	7	with	with	IN
10_1101-2021_01_08_423993	364	8	its	-PRON-	PRP$
10_1101-2021_01_08_423993	364	9	b	b	NNP
10_1101-2021_01_08_423993	364	10	-	-	HYPH
10_1101-2021_01_08_423993	364	11	lactam	lactam	NNP
10_1101-2021_01_08_423993	364	12	carbonyl	carbonyl	NNP
10_1101-2021_01_08_423993	364	13	located	locate	VBN
10_1101-2021_01_08_423993	364	14	at	at	IN
10_1101-2021_01_08_423993	364	15	the	the	DT
10_1101-2021_01_08_423993	364	16	active	active	JJ
10_1101-2021_01_08_423993	364	17	site	site	NN
10_1101-2021_01_08_423993	364	18	where	where	WRB
10_1101-2021_01_08_423993	364	19	it	-PRON-	PRP
10_1101-2021_01_08_423993	364	20	ligates	ligate	VBZ
10_1101-2021_01_08_423993	364	21	to	to	IN
10_1101-2021_01_08_423993	364	22	one	one	CD
10_1101-2021_01_08_423993	364	23	zinc	zinc	NN
10_1101-2021_01_08_423993	364	24	(	(	-LRB-
10_1101-2021_01_08_423993	364	25	or	or	CC
10_1101-2021_01_08_423993	364	26	other	other	JJ
10_1101-2021_01_08_423993	364	27	metal	metal	NN
10_1101-2021_01_08_423993	364	28	)	)	-RRB-
10_1101-2021_01_08_423993	364	29	ion	ion	NN
10_1101-2021_01_08_423993	364	30	,	,	,
10_1101-2021_01_08_423993	364	31	but	but	CC
10_1101-2021_01_08_423993	364	32	instead	instead	RB
10_1101-2021_01_08_423993	364	33	binds	bind	VBZ
10_1101-2021_01_08_423993	364	34	the	the	DT
10_1101-2021_01_08_423993	364	35	single	single	JJ
10_1101-2021_01_08_423993	364	36	nickel	nickel	NN
10_1101-2021_01_08_423993	364	37	ion	ion	NN
10_1101-2021_01_08_423993	364	38	in	in	IN
10_1101-2021_01_08_423993	364	39	bidentate	bidentate	NNP
10_1101-2021_01_08_423993	364	40	manner	manner	NN
10_1101-2021_01_08_423993	364	41	via	via	IN
10_1101-2021_01_08_423993	364	42	the	the	DT
10_1101-2021_01_08_423993	364	43	carbonyls	carbonyls	NN
10_1101-2021_01_08_423993	364	44	of	of	IN
10_1101-2021_01_08_423993	364	45	its	-PRON-	PRP$
10_1101-2021_01_08_423993	364	46	cyclic	cyclic	JJ
10_1101-2021_01_08_423993	364	47	1,2	1,2	NN
10_1101-2021_01_08_423993	364	48	diamide	diamide	NN
10_1101-2021_01_08_423993	364	49	on	on	IN
10_1101-2021_01_08_423993	364	50	its	-PRON-	PRP$
10_1101-2021_01_08_423993	364	51	C-3	C-3	NNP
10_1101-2021_01_08_423993	364	52	’	'	''
10_1101-2021_01_08_423993	364	53	sidechain	sidechain	NN
10_1101-2021_01_08_423993	364	54	.	.	.
10_1101-2021_01_08_423993	365	1	[	[	-LRB-
10_1101-2021_01_08_423993	365	2	74,78	74,78	CD
10_1101-2021_01_08_423993	365	3	]	]	-RRB-
10_1101-2021_01_08_423993	365	4	.	.	.
10_1101-2021_01_08_423993	366	1	Studies	study	NNS
10_1101-2021_01_08_423993	366	2	with	with	IN
10_1101-2021_01_08_423993	366	3	the	the	DT
10_1101-2021_01_08_423993	366	4	true	true	JJ
10_1101-2021_01_08_423993	366	5	MBLs	mbl	NNS
10_1101-2021_01_08_423993	366	6	have	have	VBP
10_1101-2021_01_08_423993	366	7	shown	show	VBN
10_1101-2021_01_08_423993	366	8	that	that	DT
10_1101-2021_01_08_423993	366	9	appropriate	appropriate	JJ
10_1101-2021_01_08_423993	366	10	derivatisation	derivatisation	NN
10_1101-2021_01_08_423993	366	11	of	of	IN
10_1101-2021_01_08_423993	366	12	weakly	weakly	RB
10_1101-2021_01_08_423993	366	13	binding	bind	VBG
10_1101-2021_01_08_423993	366	14	molecules	molecule	NNS
10_1101-2021_01_08_423993	366	15	can	can	MD
10_1101-2021_01_08_423993	366	16	lead	lead	VB
10_1101-2021_01_08_423993	366	17	to	to	IN
10_1101-2021_01_08_423993	366	18	highly	highly	RB
10_1101-2021_01_08_423993	366	19	potent	potent	JJ
10_1101-2021_01_08_423993	366	20	and	and	CC
10_1101-2021_01_08_423993	366	21	selective	selective	JJ
10_1101-2021_01_08_423993	366	22	inhibitors	inhibitor	NNS
10_1101-2021_01_08_423993	366	23	.	.	.
10_1101-2021_01_08_423993	367	1	In	in	IN
10_1101-2021_01_08_423993	367	2	proof	proof	NN
10_1101-2021_01_08_423993	367	3	of	of	IN
10_1101-2021_01_08_423993	367	4	principle	principle	JJ
10_1101-2021_01_08_423993	367	5	attempts	attempt	NNS
10_1101-2021_01_08_423993	367	6	to	to	TO
10_1101-2021_01_08_423993	367	7	inhibit	inhibit	VB
10_1101-2021_01_08_423993	367	8	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	367	9	though	though	IN
10_1101-2021_01_08_423993	367	10	its	-PRON-	PRP$
10_1101-2021_01_08_423993	367	11	novel	novel	JJ
10_1101-2021_01_08_423993	367	12	structural	structural	JJ
10_1101-2021_01_08_423993	367	13	feature	feature	NN
10_1101-2021_01_08_423993	367	14	compared	compare	VBN
10_1101-2021_01_08_423993	367	15	to	to	IN
10_1101-2021_01_08_423993	367	16	other	other	JJ
10_1101-2021_01_08_423993	367	17	MBL	MBL	NNP
10_1101-2021_01_08_423993	367	18	fold	fold	VB
10_1101-2021_01_08_423993	367	19	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	367	20	,	,	,
10_1101-2021_01_08_423993	367	21	i.e.	i.e.	FW
10_1101-2021_01_08_423993	368	1	via	via	IN
10_1101-2021_01_08_423993	368	2	its	-PRON-	PRP$
10_1101-2021_01_08_423993	368	3	zinc	zinc	NN
10_1101-2021_01_08_423993	368	4	-	-	HYPH
10_1101-2021_01_08_423993	368	5	finger	finger	NN
10_1101-2021_01_08_423993	368	6	like	like	IN
10_1101-2021_01_08_423993	368	7	motif	motif	NN
10_1101-2021_01_08_423993	368	8	,	,	,
10_1101-2021_01_08_423993	368	9	we	-PRON-	PRP
10_1101-2021_01_08_423993	368	10	tested	test	VBD
10_1101-2021_01_08_423993	368	11	three	three	CD
10_1101-2021_01_08_423993	368	12	covalent	covalent	NN
10_1101-2021_01_08_423993	368	13	inhibitors	inhibitor	NNS
10_1101-2021_01_08_423993	368	14	with	with	IN
10_1101-2021_01_08_423993	368	15	thiol	thiol	NN
10_1101-2021_01_08_423993	368	16	-	-	HYPH
10_1101-2021_01_08_423993	368	17	reactive	reactive	JJ
10_1101-2021_01_08_423993	368	18	groups	group	NNS
10_1101-2021_01_08_423993	368	19	.	.	.
10_1101-2021_01_08_423993	369	1	Ebselen	Ebselen	NNP
10_1101-2021_01_08_423993	369	2	,	,	,
10_1101-2021_01_08_423993	369	3	disulfiram	disulfiram	NNP
10_1101-2021_01_08_423993	369	4	and	and	CC
10_1101-2021_01_08_423993	369	5	auranofin	auranofin	NNP
10_1101-2021_01_08_423993	369	6	have	have	VBP
10_1101-2021_01_08_423993	369	7	the	the	DT
10_1101-2021_01_08_423993	369	8	potential	potential	NN
10_1101-2021_01_08_423993	369	9	to	to	TO
10_1101-2021_01_08_423993	369	10	interact	interact	VB
10_1101-2021_01_08_423993	369	11	with	with	IN
10_1101-2021_01_08_423993	369	12	zinc	zinc	NN
10_1101-2021_01_08_423993	369	13	fingers	finger	NNS
10_1101-2021_01_08_423993	369	14	,	,	,
10_1101-2021_01_08_423993	369	15	including	include	VBG
10_1101-2021_01_08_423993	369	16	via	via	IN
10_1101-2021_01_08_423993	369	17	zinc	zinc	NN
10_1101-2021_01_08_423993	369	18	ejection	ejection	NN
10_1101-2021_01_08_423993	369	19	with	with	IN
10_1101-2021_01_08_423993	369	20	consequent	consequent	JJ
10_1101-2021_01_08_423993	369	21	protein	protein	NN
10_1101-2021_01_08_423993	369	22	destabilization	destabilization	NN
10_1101-2021_01_08_423993	369	23	[	[	-LRB-
10_1101-2021_01_08_423993	369	24	69,70,79,80	69,70,79,80	NN
10_1101-2021_01_08_423993	369	25	]	]	-RRB-
10_1101-2021_01_08_423993	369	26	.	.	.
10_1101-2021_01_08_423993	370	1	Both	both	DT
10_1101-2021_01_08_423993	370	2	ebselen	ebselen	JJ
10_1101-2021_01_08_423993	370	3	and	and	CC
10_1101-2021_01_08_423993	370	4	auranofin	auranofin	NN
10_1101-2021_01_08_423993	370	5	are	be	VBP
10_1101-2021_01_08_423993	370	6	reported	report	VBN
10_1101-2021_01_08_423993	370	7	have	have	VBP
10_1101-2021_01_08_423993	370	8	some	some	DT
10_1101-2021_01_08_423993	370	9	antimicrobial	antimicrobial	JJ
10_1101-2021_01_08_423993	370	10	properties	property	NNS
10_1101-2021_01_08_423993	370	11	[	[	-LRB-
10_1101-2021_01_08_423993	370	12	81	81	CD
10_1101-2021_01_08_423993	370	13	]	]	-RRB-
10_1101-2021_01_08_423993	370	14	,	,	,
10_1101-2021_01_08_423993	370	15	ebselen	ebselen	NNP
10_1101-2021_01_08_423993	370	16	is	be	VBZ
10_1101-2021_01_08_423993	370	17	in	in	IN
10_1101-2021_01_08_423993	370	18	clinical	clinical	JJ
10_1101-2021_01_08_423993	370	19	trials	trial	NNS
10_1101-2021_01_08_423993	370	20	for	for	IN
10_1101-2021_01_08_423993	370	21	a	a	DT
10_1101-2021_01_08_423993	370	22	variety	variety	NN
10_1101-2021_01_08_423993	370	23	of	of	IN
10_1101-2021_01_08_423993	370	24	conditions	condition	NNS
10_1101-2021_01_08_423993	370	25	,	,	,
10_1101-2021_01_08_423993	370	26	ranging	range	VBG
10_1101-2021_01_08_423993	370	27	from	from	IN
10_1101-2021_01_08_423993	370	28	stroke	stroke	NN
10_1101-2021_01_08_423993	370	29	to	to	IN
10_1101-2021_01_08_423993	370	30	bipolar	bipolar	JJ
10_1101-2021_01_08_423993	370	31	disorder	disorder	NN
10_1101-2021_01_08_423993	370	32	[	[	-LRB-
10_1101-2021_01_08_423993	370	33	82	82	CD
10_1101-2021_01_08_423993	370	34	]	]	-RRB-
10_1101-2021_01_08_423993	370	35	,	,	,
10_1101-2021_01_08_423993	370	36	and	and	CC
10_1101-2021_01_08_423993	370	37	auranofin	auranofin	NNP
10_1101-2021_01_08_423993	370	38	is	be	VBZ
10_1101-2021_01_08_423993	370	39	used	use	VBN
10_1101-2021_01_08_423993	370	40	for	for	IN
10_1101-2021_01_08_423993	370	41	treatment	treatment	NN
10_1101-2021_01_08_423993	370	42	of	of	IN
10_1101-2021_01_08_423993	370	43	rheumatoid	rheumatoid	NNP
10_1101-2021_01_08_423993	370	44	arthritis	arthritis	NNP
10_1101-2021_01_08_423993	370	45	[	[	-LRB-
10_1101-2021_01_08_423993	370	46	83	83	CD
10_1101-2021_01_08_423993	370	47	]	]	-RRB-
10_1101-2021_01_08_423993	370	48	.	.	.
10_1101-2021_01_08_423993	371	1	Recent	recent	JJ
10_1101-2021_01_08_423993	371	2	studies	study	NNS
10_1101-2021_01_08_423993	371	3	have	have	VBP
10_1101-2021_01_08_423993	371	4	also	also	RB
10_1101-2021_01_08_423993	371	5	shown	show	VBN
10_1101-2021_01_08_423993	371	6	that	that	IN
10_1101-2021_01_08_423993	371	7	ebselen	ebselen	JJ
10_1101-2021_01_08_423993	371	8	inhibits	inhibit	NNS
10_1101-2021_01_08_423993	371	9	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	371	10	from	from	IN
10_1101-2021_01_08_423993	371	11	SARS-	SARS-	NNP
10_1101-2021_01_08_423993	371	12	CoV-2	CoV-2	NNP
10_1101-2021_01_08_423993	371	13	,	,	,
10_1101-2021_01_08_423993	371	14	i.e.	i.e.	FW
10_1101-2021_01_08_423993	372	1	the	the	DT
10_1101-2021_01_08_423993	372	2	main	main	JJ
10_1101-2021_01_08_423993	372	3	protease	protease	NN
10_1101-2021_01_08_423993	372	4	(	(	-LRB-
10_1101-2021_01_08_423993	372	5	Mpro	Mpro	NNP
10_1101-2021_01_08_423993	372	6	)	)	-RRB-
10_1101-2021_01_08_423993	372	7	and	and	CC
10_1101-2021_01_08_423993	372	8	the	the	DT
10_1101-2021_01_08_423993	372	9	exonuclease	exonuclease	NN
10_1101-2021_01_08_423993	372	10	ExoN	ExoN	NNP
10_1101-2021_01_08_423993	372	11	(	(	-LRB-
10_1101-2021_01_08_423993	372	12	nsp14ExoN	nsp14ExoN	NNP
10_1101-2021_01_08_423993	372	13	-	-	HYPH
10_1101-2021_01_08_423993	372	14	nsp10	nsp10	NNP
10_1101-2021_01_08_423993	372	15	)	)	-RRB-
10_1101-2021_01_08_423993	372	16	complex	complex	JJ
10_1101-2021_01_08_423993	372	17	[	[	-LRB-
10_1101-2021_01_08_423993	372	18	84,85	84,85	CD
10_1101-2021_01_08_423993	372	19	]	]	-RRB-
10_1101-2021_01_08_423993	372	20	.	.	.
10_1101-2021_01_08_423993	373	1	Disulfiram	Disulfiram	NNP
10_1101-2021_01_08_423993	373	2	is	be	VBZ
10_1101-2021_01_08_423993	373	3	a	a	DT
10_1101-2021_01_08_423993	373	4	known	known	JJ
10_1101-2021_01_08_423993	373	5	acetaldehyde	acetaldehyde	NN
10_1101-2021_01_08_423993	373	6	dehydrogenase	dehydrogenase	NN
10_1101-2021_01_08_423993	373	7	inhibitor	inhibitor	NN
10_1101-2021_01_08_423993	373	8	used	use	VBN
10_1101-2021_01_08_423993	373	9	in	in	IN
10_1101-2021_01_08_423993	373	10	treatment	treatment	NN
10_1101-2021_01_08_423993	373	11	for	for	IN
10_1101-2021_01_08_423993	373	12	alcohol	alcohol	NN
10_1101-2021_01_08_423993	373	13	abuse	abuse	NN
10_1101-2021_01_08_423993	373	14	disorder	disorder	NN
10_1101-2021_01_08_423993	373	15	[	[	-LRB-
10_1101-2021_01_08_423993	373	16	86	86	CD
10_1101-2021_01_08_423993	373	17	]	]	-RRB-
10_1101-2021_01_08_423993	373	18	.	.	.
10_1101-2021_01_08_423993	374	1	Our	-PRON-	PRP$
10_1101-2021_01_08_423993	374	2	results	result	NNS
10_1101-2021_01_08_423993	374	3	show	show	VBP
10_1101-2021_01_08_423993	374	4	that	that	IN
10_1101-2021_01_08_423993	374	5	both	both	DT
10_1101-2021_01_08_423993	374	6	ebselen	ebselen	NNP
10_1101-2021_01_08_423993	374	7	and	and	CC
10_1101-2021_01_08_423993	374	8	disulfiram	disulfiram	NNP
10_1101-2021_01_08_423993	374	9	inhibit	inhibit	VBP
10_1101-2021_01_08_423993	374	10	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	374	11	(	(	-LRB-
10_1101-2021_01_08_423993	374	12	IC50s	IC50s	NNP
10_1101-2021_01_08_423993	374	13	8.5	8.5	CD
10_1101-2021_01_08_423993	374	14	µM	µM	NNP
10_1101-2021_01_08_423993	374	15	and	and	CC
10_1101-2021_01_08_423993	374	16	10.8	10.8	CD
10_1101-2021_01_08_423993	374	17	µM	µM	NNP
10_1101-2021_01_08_423993	374	18	,	,	,
10_1101-2021_01_08_423993	374	19	respectively	respectively	RB
10_1101-2021_01_08_423993	374	20	)	)	-RRB-
10_1101-2021_01_08_423993	374	21	,	,	,
10_1101-2021_01_08_423993	374	22	whilst	whilst	IN
10_1101-2021_01_08_423993	374	23	auranofin	auranofin	NNP
10_1101-2021_01_08_423993	374	24	is	be	VBZ
10_1101-2021_01_08_423993	374	25	less	less	RBR
10_1101-2021_01_08_423993	374	26	potent	potent	JJ
10_1101-2021_01_08_423993	374	27	(	(	-LRB-
10_1101-2021_01_08_423993	374	28	IC5046	IC5046	NNP
10_1101-2021_01_08_423993	374	29	µM	µM	NNP
10_1101-2021_01_08_423993	374	30	)	)	-RRB-
10_1101-2021_01_08_423993	374	31	.	.	.
10_1101-2021_01_08_423993	375	1	Studies	study	NNS
10_1101-2021_01_08_423993	375	2	focussed	focusse	VBN
10_1101-2021_01_08_423993	375	3	on	on	IN
10_1101-2021_01_08_423993	375	4	inhibiting	inhibit	VBG
10_1101-2021_01_08_423993	375	5	the	the	DT
10_1101-2021_01_08_423993	375	6	MBL	MBL	NNP
10_1101-2021_01_08_423993	375	7	fold	fold	JJ
10_1101-2021_01_08_423993	375	8	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	375	9	are	be	VBP
10_1101-2021_01_08_423993	375	10	at	at	IN
10_1101-2021_01_08_423993	375	11	an	an	DT
10_1101-2021_01_08_423993	375	12	early	early	JJ
10_1101-2021_01_08_423993	375	13	stage	stage	NN
10_1101-2021_01_08_423993	375	14	compared	compare	VBN
10_1101-2021_01_08_423993	375	15	with	with	IN
10_1101-2021_01_08_423993	375	16	work	work	NN
10_1101-2021_01_08_423993	375	17	on	on	IN
10_1101-2021_01_08_423993	375	18	the	the	DT
10_1101-2021_01_08_423993	375	19	true	true	JJ
10_1101-2021_01_08_423993	375	20	MBLs	mbl	NNS
10_1101-2021_01_08_423993	375	21	.	.	.
10_1101-2021_01_08_423993	376	1	The	the	DT
10_1101-2021_01_08_423993	376	2	structures	structure	NNS
10_1101-2021_01_08_423993	376	3	and	and	CC
10_1101-2021_01_08_423993	376	4	assays	assays	RB
10_1101-2021_01_08_423993	376	5	results	result	NNS
10_1101-2021_01_08_423993	376	6	presented	present	VBN
10_1101-2021_01_08_423993	376	7	here	here	RB
10_1101-2021_01_08_423993	376	8	provide	provide	VBP
10_1101-2021_01_08_423993	376	9	starting	start	VBG
10_1101-2021_01_08_423993	376	10	points	point	NNS
10_1101-2021_01_08_423993	376	11	with	with	IN
10_1101-2021_01_08_423993	376	12	established	establish	VBN
10_1101-2021_01_08_423993	376	13	drugs	drug	NNS
10_1101-2021_01_08_423993	376	14	,	,	,
10_1101-2021_01_08_423993	376	15	from	from	IN
10_1101-2021_01_08_423993	376	16	which	which	WDT
10_1101-2021_01_08_423993	376	17	it	-PRON-	PRP
10_1101-2021_01_08_423993	376	18	might	may	MD
10_1101-2021_01_08_423993	376	19	be	be	VB
10_1101-2021_01_08_423993	376	20	possible	possible	JJ
10_1101-2021_01_08_423993	376	21	to	to	TO
10_1101-2021_01_08_423993	376	22	generate	generate	VB
10_1101-2021_01_08_423993	376	23	selective	selective	JJ
10_1101-2021_01_08_423993	376	24	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	376	25	inhibitors	inhibitor	NNS
10_1101-2021_01_08_423993	376	26	,	,	,
10_1101-2021_01_08_423993	376	27	either	either	CC
10_1101-2021_01_08_423993	376	28	binding	bind	VBG
10_1101-2021_01_08_423993	376	29	at	at	IN
10_1101-2021_01_08_423993	376	30	the	the	DT
10_1101-2021_01_08_423993	376	31	active	active	JJ
10_1101-2021_01_08_423993	376	32	site	site	NN
10_1101-2021_01_08_423993	376	33	or	or	CC
10_1101-2021_01_08_423993	376	34	elsewhere	elsewhere	RB
10_1101-2021_01_08_423993	376	35	(	(	-LRB-
10_1101-2021_01_08_423993	376	36	including	include	VBG
10_1101-2021_01_08_423993	376	37	the	the	DT
10_1101-2021_01_08_423993	376	38	apparently	apparently	RB
10_1101-2021_01_08_423993	376	39	unique	unique	JJ
10_1101-2021_01_08_423993	376	40	zinc	zinc	NN
10_1101-2021_01_08_423993	376	41	finger	finger	NN
10_1101-2021_01_08_423993	376	42	of	of	IN
10_1101-2021_01_08_423993	376	43	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	376	44	)	)	-RRB-
10_1101-2021_01_08_423993	376	45	,	,	,
10_1101-2021_01_08_423993	376	46	in	in	IN
10_1101-2021_01_08_423993	376	47	order	order	NN
10_1101-2021_01_08_423993	376	48	to	to	TO
10_1101-2021_01_08_423993	376	49	radiosensitise	radiosensitise	VB
10_1101-2021_01_08_423993	376	50	cells	cell	NNS
10_1101-2021_01_08_423993	376	51	.	.	.
10_1101-2021_01_08_423993	377	1	ACCESSION	ACCESSION	NNP
10_1101-2021_01_08_423993	377	2	NUMBERS	number	NNS
10_1101-2021_01_08_423993	377	3	Coordinates	coordinate	NNS
10_1101-2021_01_08_423993	377	4	and	and	CC
10_1101-2021_01_08_423993	377	5	structure	structure	NN
10_1101-2021_01_08_423993	377	6	factors	factor	NNS
10_1101-2021_01_08_423993	377	7	have	have	VBP
10_1101-2021_01_08_423993	377	8	been	be	VBN
10_1101-2021_01_08_423993	377	9	deposited	deposit	VBN
10_1101-2021_01_08_423993	377	10	in	in	IN
10_1101-2021_01_08_423993	377	11	the	the	DT
10_1101-2021_01_08_423993	377	12	Protein	Protein	NNP
10_1101-2021_01_08_423993	377	13	Data	Data	NNPS
10_1101-2021_01_08_423993	377	14	Bank	Bank	NNP
10_1101-2021_01_08_423993	377	15	under	under	IN
10_1101-2021_01_08_423993	377	16	accession	accession	NN
10_1101-2021_01_08_423993	377	17	codes	code	NNS
10_1101-2021_01_08_423993	377	18	6TT5	6tt5	CD
10_1101-2021_01_08_423993	377	19	,	,	,
10_1101-2021_01_08_423993	377	20	7AF1	7af1	CD
10_1101-2021_01_08_423993	377	21	,	,	,
10_1101-2021_01_08_423993	377	22	7AFS	7afs	CD
10_1101-2021_01_08_423993	377	23	,	,	,
10_1101-2021_01_08_423993	377	24	7AFU	7AFU	NNP
10_1101-2021_01_08_423993	377	25	,	,	,
10_1101-2021_01_08_423993	377	26	7AGI	7AGI	NNP
10_1101-2021_01_08_423993	377	27	,	,	,
10_1101-2021_01_08_423993	377	28	7APV	7APV	NNP
10_1101-2021_01_08_423993	377	29	and	and	CC
10_1101-2021_01_08_423993	377	30	7ABS	7ABS	NNP
10_1101-2021_01_08_423993	377	31	.	.	.
10_1101-2021_01_08_423993	378	1	SUPPLEMENTARY	SUPPLEMENTARY	NNP
10_1101-2021_01_08_423993	378	2	DATA	datum	NNS
10_1101-2021_01_08_423993	378	3	.CC	.CC	NFP
10_1101-2021_01_08_423993	378	4	-	-	:
10_1101-2021_01_08_423993	378	5	BY	by	IN
10_1101-2021_01_08_423993	378	6	4.0	4.0	CD
10_1101-2021_01_08_423993	378	7	International	international	JJ
10_1101-2021_01_08_423993	378	8	licensemade	licensemade	NN
10_1101-2021_01_08_423993	378	9	available	available	JJ
10_1101-2021_01_08_423993	378	10	under	under	IN
10_1101-2021_01_08_423993	378	11	a	a	DT
10_1101-2021_01_08_423993	378	12	(	(	-LRB-
10_1101-2021_01_08_423993	378	13	which	which	WDT
10_1101-2021_01_08_423993	378	14	was	be	VBD
10_1101-2021_01_08_423993	378	15	not	not	RB
10_1101-2021_01_08_423993	378	16	certified	certify	VBN
10_1101-2021_01_08_423993	378	17	by	by	IN
10_1101-2021_01_08_423993	378	18	peer	peer	NN
10_1101-2021_01_08_423993	378	19	review	review	NN
10_1101-2021_01_08_423993	378	20	)	)	-RRB-
10_1101-2021_01_08_423993	378	21	is	be	VBZ
10_1101-2021_01_08_423993	378	22	the	the	DT
10_1101-2021_01_08_423993	378	23	author	author	NN
10_1101-2021_01_08_423993	378	24	/	/	SYM
10_1101-2021_01_08_423993	378	25	funder	funder	NN
10_1101-2021_01_08_423993	378	26	,	,	,
10_1101-2021_01_08_423993	378	27	who	who	WP
10_1101-2021_01_08_423993	378	28	has	have	VBZ
10_1101-2021_01_08_423993	378	29	granted	grant	VBN
10_1101-2021_01_08_423993	378	30	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	378	31	a	a	DT
10_1101-2021_01_08_423993	378	32	license	license	NN
10_1101-2021_01_08_423993	378	33	to	to	TO
10_1101-2021_01_08_423993	378	34	display	display	VB
10_1101-2021_01_08_423993	378	35	the	the	DT
10_1101-2021_01_08_423993	378	36	preprint	preprint	NN
10_1101-2021_01_08_423993	378	37	in	in	IN
10_1101-2021_01_08_423993	378	38	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	378	39	.	.	.
10_1101-2021_01_08_423993	379	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	379	2	is	be	VBZ
10_1101-2021_01_08_423993	379	3	The	the	DT
10_1101-2021_01_08_423993	379	4	copyright	copyright	NN
10_1101-2021_01_08_423993	379	5	holder	holder	NN
10_1101-2021_01_08_423993	379	6	for	for	IN
10_1101-2021_01_08_423993	379	7	this	this	DT
10_1101-2021_01_08_423993	379	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	379	9	version	version	NN
10_1101-2021_01_08_423993	379	10	posted	post	VBD
10_1101-2021_01_08_423993	379	11	January	January	NNP
10_1101-2021_01_08_423993	379	12	8	8	CD
10_1101-2021_01_08_423993	379	13	,	,	,
10_1101-2021_01_08_423993	379	14	2021	2021	CD
10_1101-2021_01_08_423993	379	15	.	.	.
10_1101-2021_01_08_423993	379	16	;	;	:
10_1101-2021_01_08_423993	379	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	379	18	:	:	:
10_1101-2021_01_08_423993	379	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	379	20	preprint	preprint	NN
10_1101-2021_01_08_423993	379	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	PRP
10_1101-2021_01_08_423993	379	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2021_01_08_423993	379	23	Supplementary	Supplementary	NNP
10_1101-2021_01_08_423993	379	24	Data	Data	NNP
10_1101-2021_01_08_423993	379	25	are	be	VBP
10_1101-2021_01_08_423993	379	26	available	available	JJ
10_1101-2021_01_08_423993	379	27	at	at	IN
10_1101-2021_01_08_423993	379	28	NAR	NAR	NNP
10_1101-2021_01_08_423993	379	29	online	online	RB
10_1101-2021_01_08_423993	379	30	.	.	.
10_1101-2021_01_08_423993	380	1	ACKNOWLEDGEMENT	acknowledgement	VBP
10_1101-2021_01_08_423993	380	2	We	-PRON-	PRP
10_1101-2021_01_08_423993	380	3	are	be	VBP
10_1101-2021_01_08_423993	380	4	very	very	RB
10_1101-2021_01_08_423993	380	5	grateful	grateful	JJ
10_1101-2021_01_08_423993	380	6	to	to	IN
10_1101-2021_01_08_423993	380	7	Dr	Dr	NNP
10_1101-2021_01_08_423993	380	8	Rod	Rod	NNP
10_1101-2021_01_08_423993	380	9	Chalk	Chalk	NNP
10_1101-2021_01_08_423993	380	10	and	and	CC
10_1101-2021_01_08_423993	380	11	Tiago	Tiago	NNP
10_1101-2021_01_08_423993	380	12	Moreira	Moreira	NNP
10_1101-2021_01_08_423993	380	13	for	for	IN
10_1101-2021_01_08_423993	380	14	mass	mass	NN
10_1101-2021_01_08_423993	380	15	spectrometry	spectrometry	NN
10_1101-2021_01_08_423993	380	16	,	,	,
10_1101-2021_01_08_423993	380	17	and	and	CC
10_1101-2021_01_08_423993	380	18	Dr	Dr	NNP
10_1101-2021_01_08_423993	380	19	Neil	Neil	NNP
10_1101-2021_01_08_423993	380	20	Patterson	Patterson	NNP
10_1101-2021_01_08_423993	380	21	for	for	IN
10_1101-2021_01_08_423993	380	22	the	the	DT
10_1101-2021_01_08_423993	380	23	helpful	helpful	JJ
10_1101-2021_01_08_423993	380	24	discussions	discussion	NNS
10_1101-2021_01_08_423993	380	25	and	and	CC
10_1101-2021_01_08_423993	380	26	data	datum	NNS
10_1101-2021_01_08_423993	380	27	collections	collection	NNS
10_1101-2021_01_08_423993	380	28	at	at	IN
10_1101-2021_01_08_423993	380	29	Diamond	Diamond	NNP
10_1101-2021_01_08_423993	380	30	Light	Light	NNP
10_1101-2021_01_08_423993	380	31	Source	Source	NNP
10_1101-2021_01_08_423993	380	32	.	.	.
10_1101-2021_01_08_423993	381	1	We	-PRON-	PRP
10_1101-2021_01_08_423993	381	2	acknowledge	acknowledge	VBP
10_1101-2021_01_08_423993	381	3	Diamond	Diamond	NNP
10_1101-2021_01_08_423993	381	4	Light	Light	NNP
10_1101-2021_01_08_423993	381	5	Source	Source	NNP
10_1101-2021_01_08_423993	381	6	for	for	IN
10_1101-2021_01_08_423993	381	7	time	time	NN
10_1101-2021_01_08_423993	381	8	on	on	IN
10_1101-2021_01_08_423993	381	9	Beamlines	Beamlines	NNP
10_1101-2021_01_08_423993	381	10	I03	I03	NNP
10_1101-2021_01_08_423993	381	11	,	,	,
10_1101-2021_01_08_423993	381	12	I04	I04	NNP
10_1101-2021_01_08_423993	381	13	and	and	CC
10_1101-2021_01_08_423993	381	14	I24	I24	NNP
10_1101-2021_01_08_423993	381	15	under	under	IN
10_1101-2021_01_08_423993	381	16	Proposal	Proposal	NNP
10_1101-2021_01_08_423993	381	17	MX19301	mx19301	NN
10_1101-2021_01_08_423993	381	18	.	.	.
10_1101-2021_01_08_423993	382	1	FUNDING	fund	VBG
10_1101-2021_01_08_423993	382	2	This	this	DT
10_1101-2021_01_08_423993	382	3	work	work	NN
10_1101-2021_01_08_423993	382	4	was	be	VBD
10_1101-2021_01_08_423993	382	5	supported	support	VBN
10_1101-2021_01_08_423993	382	6	by	by	IN
10_1101-2021_01_08_423993	382	7	a	a	DT
10_1101-2021_01_08_423993	382	8	Cancer	Cancer	NNP
10_1101-2021_01_08_423993	382	9	Research	Research	NNP
10_1101-2021_01_08_423993	382	10	UK	UK	NNP
10_1101-2021_01_08_423993	382	11	Programme	Programme	NNP
10_1101-2021_01_08_423993	382	12	Award	Award	NNP
10_1101-2021_01_08_423993	382	13	[	[	-LRB-
10_1101-2021_01_08_423993	382	14	A24759	a24759	NN
10_1101-2021_01_08_423993	382	15	to	to	IN
10_1101-2021_01_08_423993	382	16	PJM	PJM	NNP
10_1101-2021_01_08_423993	382	17	,	,	,
10_1101-2021_01_08_423993	382	18	OG	OG	NNP
10_1101-2021_01_08_423993	382	19	and	and	CC
10_1101-2021_01_08_423993	382	20	CJS	CJS	NNP
10_1101-2021_01_08_423993	382	21	]	]	-RRB-
10_1101-2021_01_08_423993	382	22	and	and	CC
10_1101-2021_01_08_423993	382	23	Wellcome	Wellcome	NNP
10_1101-2021_01_08_423993	382	24	trust	trust	NN
10_1101-2021_01_08_423993	382	25	grant	grant	NN
10_1101-2021_01_08_423993	382	26	[	[	-LRB-
10_1101-2021_01_08_423993	382	27	106169	106169	CD
10_1101-2021_01_08_423993	382	28	/	/	SYM
10_1101-2021_01_08_423993	382	29	ZZ14	ZZ14	NNP
10_1101-2021_01_08_423993	382	30	/	/	SYM
10_1101-2021_01_08_423993	382	31	Z	Z	NNP
10_1101-2021_01_08_423993	382	32	to	to	IN
10_1101-2021_01_08_423993	382	33	OG	OG	NNP
10_1101-2021_01_08_423993	382	34	and	and	CC
10_1101-2021_01_08_423993	382	35	106244	106244	CD
10_1101-2021_01_08_423993	382	36	/	/	SYM
10_1101-2021_01_08_423993	382	37	Z/14	Z/14	NNP
10_1101-2021_01_08_423993	382	38	/	/	SYM
10_1101-2021_01_08_423993	382	39	Z	Z	NNP
10_1101-2021_01_08_423993	382	40	to	to	IN
10_1101-2021_01_08_423993	382	41	CJS	CJS	NNP
10_1101-2021_01_08_423993	382	42	]	]	-RRB-
10_1101-2021_01_08_423993	382	43	.	.	.
10_1101-2021_01_08_423993	383	1	CONFLICT	conflict	NN
10_1101-2021_01_08_423993	383	2	OF	of	IN
10_1101-2021_01_08_423993	383	3	INTEREST	interest	NN
10_1101-2021_01_08_423993	383	4	The	the	DT
10_1101-2021_01_08_423993	383	5	authors	author	NNS
10_1101-2021_01_08_423993	383	6	declare	declare	VBP
10_1101-2021_01_08_423993	383	7	no	no	DT
10_1101-2021_01_08_423993	383	8	conflict	conflict	NN
10_1101-2021_01_08_423993	383	9	of	of	IN
10_1101-2021_01_08_423993	383	10	interest	interest	NN
10_1101-2021_01_08_423993	383	11	.	.	.
10_1101-2021_01_08_423993	384	1	REFERENCES	reference	NNS
10_1101-2021_01_08_423993	384	2	1	1	CD
10_1101-2021_01_08_423993	384	3	.	.	.
10_1101-2021_01_08_423993	385	1	Yang	Yang	NNP
10_1101-2021_01_08_423993	385	2	W	W	NNP
10_1101-2021_01_08_423993	385	3	(	(	-LRB-
10_1101-2021_01_08_423993	385	4	2011	2011	CD
10_1101-2021_01_08_423993	385	5	)	)	-RRB-
10_1101-2021_01_08_423993	385	6	Nucleases	nuclease	NNS
10_1101-2021_01_08_423993	385	7	:	:	:
10_1101-2021_01_08_423993	385	8	Diversity	diversity	NN
10_1101-2021_01_08_423993	385	9	of	of	IN
10_1101-2021_01_08_423993	385	10	structure	structure	NN
10_1101-2021_01_08_423993	385	11	,	,	,
10_1101-2021_01_08_423993	385	12	function	function	NN
10_1101-2021_01_08_423993	385	13	and	and	CC
10_1101-2021_01_08_423993	385	14	mechanism	mechanism	NN
10_1101-2021_01_08_423993	385	15	.	.	.
10_1101-2021_01_08_423993	386	1	2	2	LS
10_1101-2021_01_08_423993	386	2	.	.	.
10_1101-2021_01_08_423993	387	1	Callebaut	callebaut	NN
10_1101-2021_01_08_423993	387	2	I	I	NNP
10_1101-2021_01_08_423993	387	3	,	,	,
10_1101-2021_01_08_423993	387	4	Moshous	Moshous	NNP
10_1101-2021_01_08_423993	387	5	D	D	NNP
10_1101-2021_01_08_423993	387	6	,	,	,
10_1101-2021_01_08_423993	387	7	Mornon	Mornon	NNP
10_1101-2021_01_08_423993	387	8	J	J	NNP
10_1101-2021_01_08_423993	387	9	-	-	HYPH
10_1101-2021_01_08_423993	387	10	P	P	NNP
10_1101-2021_01_08_423993	387	11	&	&	CC
10_1101-2021_01_08_423993	387	12	De	De	NNP
10_1101-2021_01_08_423993	387	13	Villartay	Villartay	NNP
10_1101-2021_01_08_423993	387	14	JP	JP	NNP
10_1101-2021_01_08_423993	387	15	(	(	-LRB-
10_1101-2021_01_08_423993	387	16	2002	2002	CD
10_1101-2021_01_08_423993	387	17	)	)	-RRB-
10_1101-2021_01_08_423993	387	18	Metallo	Metallo	NNP
10_1101-2021_01_08_423993	387	19	-	-	HYPH
10_1101-2021_01_08_423993	387	20	beta	beta	NN
10_1101-2021_01_08_423993	387	21	-	-	HYPH
10_1101-2021_01_08_423993	387	22	lactamase	lactamase	NN
10_1101-2021_01_08_423993	387	23	fold	fold	VB
10_1101-2021_01_08_423993	387	24	within	within	IN
10_1101-2021_01_08_423993	387	25	nucleic	nucleic	NNP
10_1101-2021_01_08_423993	387	26	acids	acid	NNS
10_1101-2021_01_08_423993	387	27	processing	processing	NN
10_1101-2021_01_08_423993	387	28	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	387	29	:	:	:
10_1101-2021_01_08_423993	387	30	the	the	DT
10_1101-2021_01_08_423993	387	31	beta	beta	NN
10_1101-2021_01_08_423993	387	32	-	-	HYPH
10_1101-2021_01_08_423993	387	33	CASP	casp	NN
10_1101-2021_01_08_423993	387	34	family	family	NN
10_1101-2021_01_08_423993	387	35	.	.	.
10_1101-2021_01_08_423993	388	1	Nucleic	Nucleic	NNP
10_1101-2021_01_08_423993	388	2	Acids	Acids	NNPS
10_1101-2021_01_08_423993	388	3	Res	Res	NNP
10_1101-2021_01_08_423993	388	4	.	.	.
10_1101-2021_01_08_423993	389	1	30	30	CD
10_1101-2021_01_08_423993	389	2	,	,	,
10_1101-2021_01_08_423993	389	3	3592–3601	3592–3601	CD
10_1101-2021_01_08_423993	389	4	.	.	.
10_1101-2021_01_08_423993	390	1	3	3	LS
10_1101-2021_01_08_423993	390	2	.	.	.
10_1101-2021_01_08_423993	391	1	Allerston	Allerston	NNP
10_1101-2021_01_08_423993	391	2	CK	CK	NNP
10_1101-2021_01_08_423993	391	3	,	,	,
10_1101-2021_01_08_423993	391	4	Lee	Lee	NNP
10_1101-2021_01_08_423993	391	5	SY	SY	NNP
10_1101-2021_01_08_423993	391	6	,	,	,
10_1101-2021_01_08_423993	391	7	Newman	Newman	NNP
10_1101-2021_01_08_423993	391	8	JA	JA	NNP
10_1101-2021_01_08_423993	391	9	,	,	,
10_1101-2021_01_08_423993	391	10	Schofield	Schofield	NNP
10_1101-2021_01_08_423993	391	11	CJ	CJ	NNP
10_1101-2021_01_08_423993	391	12	,	,	,
10_1101-2021_01_08_423993	391	13	Mchugh	Mchugh	NNP
10_1101-2021_01_08_423993	391	14	PJ	PJ	NNP
10_1101-2021_01_08_423993	391	15	&	&	CC
10_1101-2021_01_08_423993	391	16	Gileadi	Gileadi	NNP
10_1101-2021_01_08_423993	391	17	O	O	NNP
10_1101-2021_01_08_423993	391	18	(	(	-LRB-
10_1101-2021_01_08_423993	391	19	2015	2015	CD
10_1101-2021_01_08_423993	391	20	)	)	-RRB-
10_1101-2021_01_08_423993	391	21	The	the	DT
10_1101-2021_01_08_423993	391	22	structures	structure	NNS
10_1101-2021_01_08_423993	391	23	of	of	IN
10_1101-2021_01_08_423993	391	24	the	the	DT
10_1101-2021_01_08_423993	391	25	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	391	26	and	and	CC
10_1101-2021_01_08_423993	391	27	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	391	28	/	/	SYM
10_1101-2021_01_08_423993	391	29	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	391	30	nuclease	nuclease	NN
10_1101-2021_01_08_423993	391	31	domains	domain	NNS
10_1101-2021_01_08_423993	391	32	reveal	reveal	VBP
10_1101-2021_01_08_423993	391	33	a	a	DT
10_1101-2021_01_08_423993	391	34	potential	potential	JJ
10_1101-2021_01_08_423993	391	35	basis	basis	NN
10_1101-2021_01_08_423993	391	36	for	for	IN
10_1101-2021_01_08_423993	391	37	their	-PRON-	PRP$
10_1101-2021_01_08_423993	391	38	distinct	distinct	JJ
10_1101-2021_01_08_423993	391	39	DNA	dna	NN
10_1101-2021_01_08_423993	391	40	processing	processing	NN
10_1101-2021_01_08_423993	391	41	activities	activity	NNS
10_1101-2021_01_08_423993	391	42	.	.	.
10_1101-2021_01_08_423993	392	1	Nucleic	Nucleic	NNP
10_1101-2021_01_08_423993	392	2	Acids	Acids	NNPS
10_1101-2021_01_08_423993	392	3	Res	Res	NNP
10_1101-2021_01_08_423993	392	4	.	.	.
10_1101-2021_01_08_423993	393	1	43	43	CD
10_1101-2021_01_08_423993	393	2	,	,	,
10_1101-2021_01_08_423993	393	3	11047–11060	11047–11060	CD
10_1101-2021_01_08_423993	393	4	.	.	.
10_1101-2021_01_08_423993	394	1	4	4	LS
10_1101-2021_01_08_423993	394	2	.	.	.
10_1101-2021_01_08_423993	395	1	Goodarzi	Goodarzi	NNP
10_1101-2021_01_08_423993	395	2	AA	AA	NNP
10_1101-2021_01_08_423993	395	3	,	,	,
10_1101-2021_01_08_423993	395	4	Yu	Yu	NNP
10_1101-2021_01_08_423993	395	5	Y	Y	NNP
10_1101-2021_01_08_423993	395	6	,	,	,
10_1101-2021_01_08_423993	395	7	Riballo	Riballo	NNP
10_1101-2021_01_08_423993	395	8	E	E	NNP
10_1101-2021_01_08_423993	395	9	,	,	,
10_1101-2021_01_08_423993	395	10	Douglas	Douglas	NNP
10_1101-2021_01_08_423993	395	11	P	P	NNP
10_1101-2021_01_08_423993	395	12	,	,	,
10_1101-2021_01_08_423993	395	13	Walker	Walker	NNP
10_1101-2021_01_08_423993	395	14	SA	SA	NNP
10_1101-2021_01_08_423993	395	15	,	,	,
10_1101-2021_01_08_423993	395	16	Ye	Ye	NNP
10_1101-2021_01_08_423993	395	17	R	R	NNP
10_1101-2021_01_08_423993	395	18	,	,	,
10_1101-2021_01_08_423993	395	19	Härer	Härer	NNP
10_1101-2021_01_08_423993	395	20	C	C	NNP
10_1101-2021_01_08_423993	395	21	,	,	,
10_1101-2021_01_08_423993	395	22	Marchetti	Marchetti	NNP
10_1101-2021_01_08_423993	395	23	C	C	NNP
10_1101-2021_01_08_423993	395	24	,	,	,
10_1101-2021_01_08_423993	395	25	Morrice	Morrice	NNP
10_1101-2021_01_08_423993	395	26	N	N	NNP
10_1101-2021_01_08_423993	395	27	,	,	,
10_1101-2021_01_08_423993	395	28	Jeggo	Jeggo	NNP
10_1101-2021_01_08_423993	395	29	PA	PA	NNP
10_1101-2021_01_08_423993	395	30	&	&	CC
10_1101-2021_01_08_423993	395	31	Lees	Lees	NNP
10_1101-2021_01_08_423993	395	32	-	-	HYPH
10_1101-2021_01_08_423993	395	33	Miller	Miller	NNP
10_1101-2021_01_08_423993	395	34	SP	SP	NNP
10_1101-2021_01_08_423993	395	35	(	(	-LRB-
10_1101-2021_01_08_423993	395	36	2006	2006	CD
10_1101-2021_01_08_423993	395	37	)	)	-RRB-
10_1101-2021_01_08_423993	395	38	DNA	DNA	NNP
10_1101-2021_01_08_423993	395	39	-	-	HYPH
10_1101-2021_01_08_423993	395	40	PK	PK	NNP
10_1101-2021_01_08_423993	395	41	autophosphorylation	autophosphorylation	NN
10_1101-2021_01_08_423993	395	42	facilitates	facilitate	VBZ
10_1101-2021_01_08_423993	395	43	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	395	44	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	395	45	activity	activity	NN
10_1101-2021_01_08_423993	395	46	.	.	.
10_1101-2021_01_08_423993	396	1	EMBO	EMBO	NNP
10_1101-2021_01_08_423993	396	2	J.	J.	NNP
10_1101-2021_01_08_423993	397	1	25	25	CD
10_1101-2021_01_08_423993	397	2	,	,	,
10_1101-2021_01_08_423993	397	3	3880–3889	3880–3889	CD
10_1101-2021_01_08_423993	397	4	.	.	.
10_1101-2021_01_08_423993	398	1	5	5	CD
10_1101-2021_01_08_423993	398	2	.	.	.
10_1101-2021_01_08_423993	399	1	Malu	Malu	NNP
10_1101-2021_01_08_423993	399	2	S	S	NNP
10_1101-2021_01_08_423993	399	3	,	,	,
10_1101-2021_01_08_423993	399	4	De	De	NNP
10_1101-2021_01_08_423993	399	5	Ioannes	Ioannes	NNP
10_1101-2021_01_08_423993	399	6	P	P	NNP
10_1101-2021_01_08_423993	399	7	,	,	,
10_1101-2021_01_08_423993	399	8	Kozlov	Kozlov	NNP
10_1101-2021_01_08_423993	399	9	M	M	NNP
10_1101-2021_01_08_423993	399	10	,	,	,
10_1101-2021_01_08_423993	399	11	Greene	Greene	NNP
10_1101-2021_01_08_423993	399	12	M	M	NNP
10_1101-2021_01_08_423993	399	13	,	,	,
10_1101-2021_01_08_423993	399	14	Francis	Francis	NNP
10_1101-2021_01_08_423993	399	15	D	D	NNP
10_1101-2021_01_08_423993	399	16	,	,	,
10_1101-2021_01_08_423993	399	17	Hanna	Hanna	NNP
10_1101-2021_01_08_423993	399	18	M	M	NNP
10_1101-2021_01_08_423993	399	19	,	,	,
10_1101-2021_01_08_423993	399	20	Pena	Pena	NNP
10_1101-2021_01_08_423993	399	21	J	J	NNP
10_1101-2021_01_08_423993	399	22	,	,	,
10_1101-2021_01_08_423993	399	23	Escalante	Escalante	NNP
10_1101-2021_01_08_423993	399	24	CR	CR	NNP
10_1101-2021_01_08_423993	399	25	,	,	,
10_1101-2021_01_08_423993	399	26	Kurosawa	Kurosawa	NNP
10_1101-2021_01_08_423993	399	27	A	A	NNP
10_1101-2021_01_08_423993	399	28	,	,	,
10_1101-2021_01_08_423993	399	29	Erdjument	erdjument	NN
10_1101-2021_01_08_423993	399	30	-	-	HYPH
10_1101-2021_01_08_423993	399	31	Bromage	bromage	NN
10_1101-2021_01_08_423993	399	32	H	h	NN
10_1101-2021_01_08_423993	399	33	,	,	,
10_1101-2021_01_08_423993	399	34	Tempst	Tempst	NNP
10_1101-2021_01_08_423993	399	35	P	P	NNP
10_1101-2021_01_08_423993	399	36	,	,	,
10_1101-2021_01_08_423993	399	37	Adachi	Adachi	NNP
10_1101-2021_01_08_423993	399	38	N	N	NNP
10_1101-2021_01_08_423993	399	39	,	,	,
10_1101-2021_01_08_423993	399	40	Vezzoni	Vezzoni	NNP
10_1101-2021_01_08_423993	399	41	P	P	NNP
10_1101-2021_01_08_423993	399	42	,	,	,
10_1101-2021_01_08_423993	399	43	Villa	Villa	NNP
10_1101-2021_01_08_423993	399	44	A	A	NNP
10_1101-2021_01_08_423993	399	45	,	,	,
10_1101-2021_01_08_423993	399	46	Aggarwal	Aggarwal	NNP
10_1101-2021_01_08_423993	399	47	AK	AK	NNP
10_1101-2021_01_08_423993	399	48	&	&	CC
10_1101-2021_01_08_423993	399	49	Cortes	Cortes	NNP
10_1101-2021_01_08_423993	399	50	P	P	NNP
10_1101-2021_01_08_423993	399	51	(	(	-LRB-
10_1101-2021_01_08_423993	399	52	2012	2012	CD
10_1101-2021_01_08_423993	399	53	)	)	-RRB-
10_1101-2021_01_08_423993	399	54	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	399	55	C	C	NNP
10_1101-2021_01_08_423993	399	56	-	-	HYPH
10_1101-2021_01_08_423993	399	57	terminal	terminal	NN
10_1101-2021_01_08_423993	399	58	region	region	NN
10_1101-2021_01_08_423993	399	59	facilitates	facilitate	VBZ
10_1101-2021_01_08_423993	399	60	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	399	61	recombination	recombination	NN
10_1101-2021_01_08_423993	399	62	through	through	IN
10_1101-2021_01_08_423993	399	63	its	-PRON-	PRP$
10_1101-2021_01_08_423993	399	64	interactions	interaction	NNS
10_1101-2021_01_08_423993	399	65	with	with	IN
10_1101-2021_01_08_423993	399	66	DNA	DNA	NNP
10_1101-2021_01_08_423993	399	67	Ligase	Ligase	NNP
10_1101-2021_01_08_423993	399	68	IV	IV	NNP
10_1101-2021_01_08_423993	399	69	and	and	CC
10_1101-2021_01_08_423993	399	70	DNA	DNA	NNP
10_1101-2021_01_08_423993	399	71	-	-	HYPH
10_1101-2021_01_08_423993	399	72	pkcs	pkcs	NNP
10_1101-2021_01_08_423993	399	73	.	.	.
10_1101-2021_01_08_423993	400	1	J.	J.	NNP
10_1101-2021_01_08_423993	400	2	Exp	Exp	NNP
10_1101-2021_01_08_423993	400	3	.	.	.
10_1101-2021_01_08_423993	401	1	Med	Med	NNP
10_1101-2021_01_08_423993	401	2	.	.	.
10_1101-2021_01_08_423993	402	1	209	209	CD
10_1101-2021_01_08_423993	402	2	,	,	,
10_1101-2021_01_08_423993	402	3	955–963	955–963	CD
10_1101-2021_01_08_423993	402	4	.	.	.
10_1101-2021_01_08_423993	403	1	6	6	CD
10_1101-2021_01_08_423993	403	2	.	.	.
10_1101-2021_01_08_423993	404	1	Niewolik	Niewolik	NNP
10_1101-2021_01_08_423993	404	2	D	D	NNP
10_1101-2021_01_08_423993	404	3	,	,	,
10_1101-2021_01_08_423993	404	4	Pannicke	Pannicke	NNP
10_1101-2021_01_08_423993	404	5	U	U	NNP
10_1101-2021_01_08_423993	404	6	,	,	,
10_1101-2021_01_08_423993	404	7	Lu	Lu	NNP
10_1101-2021_01_08_423993	404	8	H	H	NNP
10_1101-2021_01_08_423993	404	9	,	,	,
10_1101-2021_01_08_423993	404	10	Ma	Ma	NNP
10_1101-2021_01_08_423993	404	11	Y	Y	NNP
10_1101-2021_01_08_423993	404	12	,	,	,
10_1101-2021_01_08_423993	404	13	Wang	Wang	NNP
10_1101-2021_01_08_423993	404	14	LCV	LCV	NNP
10_1101-2021_01_08_423993	404	15	,	,	,
10_1101-2021_01_08_423993	404	16	Kulesza	Kulesza	NNP
10_1101-2021_01_08_423993	404	17	P	P	NNP
10_1101-2021_01_08_423993	404	18	,	,	,
10_1101-2021_01_08_423993	404	19	Zandi	Zandi	NNP
10_1101-2021_01_08_423993	404	20	E	E	NNP
10_1101-2021_01_08_423993	404	21	,	,	,
10_1101-2021_01_08_423993	404	22	Lieber	Lieber	NNP
10_1101-2021_01_08_423993	404	23	MR	MR	NNP
10_1101-2021_01_08_423993	404	24	&	&	CC
10_1101-2021_01_08_423993	404	25	Schwarz	Schwarz	NNP
10_1101-2021_01_08_423993	404	26	K	K	NNP
10_1101-2021_01_08_423993	404	27	(	(	-LRB-
10_1101-2021_01_08_423993	404	28	2006	2006	CD
10_1101-2021_01_08_423993	404	29	)	)	-RRB-
10_1101-2021_01_08_423993	404	30	DNA	dna	NN
10_1101-2021_01_08_423993	404	31	-	-	HYPH
10_1101-2021_01_08_423993	404	32	PKcs	pkcs	JJ
10_1101-2021_01_08_423993	404	33	dependence	dependence	NN
10_1101-2021_01_08_423993	404	34	of	of	IN
10_1101-2021_01_08_423993	404	35	artemis	artemis	NNP
10_1101-2021_01_08_423993	404	36	endonucleolytic	endonucleolytic	JJ
10_1101-2021_01_08_423993	404	37	activity	activity	NN
10_1101-2021_01_08_423993	404	38	,	,	,
10_1101-2021_01_08_423993	404	39	differences	difference	NNS
10_1101-2021_01_08_423993	404	40	between	between	IN
10_1101-2021_01_08_423993	404	41	hairpins	hairpin	NNS
10_1101-2021_01_08_423993	404	42	and	and	CC
10_1101-2021_01_08_423993	404	43	5′	5′	CD
10_1101-2021_01_08_423993	404	44	or	or	CC
10_1101-2021_01_08_423993	404	45	3′	3′	CD
10_1101-2021_01_08_423993	404	46	overhangs	overhang	NNS
10_1101-2021_01_08_423993	404	47	.	.	.
10_1101-2021_01_08_423993	405	1	J.	J.	NNP
10_1101-2021_01_08_423993	405	2	Biol	Biol	NNP
10_1101-2021_01_08_423993	405	3	.	.	.
10_1101-2021_01_08_423993	406	1	Chem	Chem	NNP
10_1101-2021_01_08_423993	406	2	.	.	.
10_1101-2021_01_08_423993	407	1	281	281	CD
10_1101-2021_01_08_423993	407	2	,	,	,
10_1101-2021_01_08_423993	407	3	33900–33909	33900–33909	CD
10_1101-2021_01_08_423993	407	4	.	.	.
10_1101-2021_01_08_423993	408	1	7	7	LS
10_1101-2021_01_08_423993	408	2	.	.	.
10_1101-2021_01_08_423993	409	1	Niewolik	Niewolik	NNP
10_1101-2021_01_08_423993	409	2	D	D	NNP
10_1101-2021_01_08_423993	409	3	,	,	,
10_1101-2021_01_08_423993	409	4	Peter	Peter	NNP
10_1101-2021_01_08_423993	409	5	I	I	NNP
10_1101-2021_01_08_423993	409	6	,	,	,
10_1101-2021_01_08_423993	409	7	Butscher	Butscher	NNP
10_1101-2021_01_08_423993	409	8	C	C	NNP
10_1101-2021_01_08_423993	409	9	&	&	CC
10_1101-2021_01_08_423993	409	10	Schwarz	Schwarz	NNP
10_1101-2021_01_08_423993	409	11	K	K	NNP
10_1101-2021_01_08_423993	409	12	(	(	-LRB-
10_1101-2021_01_08_423993	409	13	2017	2017	CD
10_1101-2021_01_08_423993	409	14	)	)	-RRB-
10_1101-2021_01_08_423993	409	15	Autoinhibition	autoinhibition	NN
10_1101-2021_01_08_423993	409	16	of	of	IN
10_1101-2021_01_08_423993	409	17	the	the	DT
10_1101-2021_01_08_423993	409	18	nuclease	nuclease	NN
10_1101-2021_01_08_423993	409	19	ARTEMIS	ARTEMIS	NNP
10_1101-2021_01_08_423993	409	20	is	be	VBZ
10_1101-2021_01_08_423993	409	21	mediated	mediate	VBN
10_1101-2021_01_08_423993	409	22	by	by	IN
10_1101-2021_01_08_423993	409	23	a	a	DT
10_1101-2021_01_08_423993	409	24	physical	physical	JJ
10_1101-2021_01_08_423993	409	25	interaction	interaction	NN
10_1101-2021_01_08_423993	409	26	between	between	IN
10_1101-2021_01_08_423993	409	27	its	-PRON-	PRP$
10_1101-2021_01_08_423993	409	28	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	409	29	and	and	CC
10_1101-2021_01_08_423993	409	30	C	c	NN
10_1101-2021_01_08_423993	409	31	-	-	HYPH
10_1101-2021_01_08_423993	409	32	terminal	terminal	NN
10_1101-2021_01_08_423993	409	33	domains	domain	NNS
10_1101-2021_01_08_423993	409	34	.	.	.
10_1101-2021_01_08_423993	410	1	J.	J.	NNP
10_1101-2021_01_08_423993	410	2	Biol	Biol	NNP
10_1101-2021_01_08_423993	410	3	.	.	.
10_1101-2021_01_08_423993	411	1	Chem	Chem	NNP
10_1101-2021_01_08_423993	411	2	.	.	.
10_1101-2021_01_08_423993	412	1	292	292	CD
10_1101-2021_01_08_423993	412	2	,	,	,
10_1101-2021_01_08_423993	412	3	3351–3365	3351–3365	CD
10_1101-2021_01_08_423993	412	4	.	.	.
10_1101-2021_01_08_423993	413	1	8	8	LS
10_1101-2021_01_08_423993	413	2	.	.	.
10_1101-2021_01_08_423993	414	1	Li	Li	NNP
10_1101-2021_01_08_423993	414	2	S	S	NNP
10_1101-2021_01_08_423993	414	3	,	,	,
10_1101-2021_01_08_423993	414	4	Chang	Chang	NNP
10_1101-2021_01_08_423993	414	5	HH	HH	NNP
10_1101-2021_01_08_423993	414	6	,	,	,
10_1101-2021_01_08_423993	414	7	Niewolik	Niewolik	NNP
10_1101-2021_01_08_423993	414	8	D	D	NNP
10_1101-2021_01_08_423993	414	9	,	,	,
10_1101-2021_01_08_423993	414	10	Hedrick	Hedrick	NNP
10_1101-2021_01_08_423993	414	11	MP	MP	NNP
10_1101-2021_01_08_423993	414	12	,	,	,
10_1101-2021_01_08_423993	414	13	Pinkerton	Pinkerton	NNP
10_1101-2021_01_08_423993	414	14	AB	AB	NNP
10_1101-2021_01_08_423993	414	15	,	,	,
10_1101-2021_01_08_423993	414	16	Hassig	Hassig	NNP
10_1101-2021_01_08_423993	414	17	CA	CA	NNP
10_1101-2021_01_08_423993	414	18	,	,	,
10_1101-2021_01_08_423993	414	19	Schwarz	Schwarz	NNP
10_1101-2021_01_08_423993	414	20	K	K	NNP
10_1101-2021_01_08_423993	414	21	&	&	CC
10_1101-2021_01_08_423993	414	22	Lieber	Lieber	NNP
10_1101-2021_01_08_423993	414	23	MR	MR	NNP
10_1101-2021_01_08_423993	414	24	(	(	-LRB-
10_1101-2021_01_08_423993	414	25	2014	2014	CD
10_1101-2021_01_08_423993	414	26	)	)	-RRB-
10_1101-2021_01_08_423993	414	27	Evidence	evidence	NN
10_1101-2021_01_08_423993	414	28	that	that	IN
10_1101-2021_01_08_423993	414	29	the	the	DT
10_1101-2021_01_08_423993	414	30	DNA	DNA	NNP
10_1101-2021_01_08_423993	414	31	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	414	32	ARTEMIS	ARTEMIS	NNP
10_1101-2021_01_08_423993	414	33	also	also	RB
10_1101-2021_01_08_423993	414	34	has	have	VBZ
10_1101-2021_01_08_423993	414	35	intrinsic	intrinsic	JJ
10_1101-2021_01_08_423993	414	36	5′-exonuclease	5′-exonuclease	CD
10_1101-2021_01_08_423993	414	37	.CC	.CC	:
10_1101-2021_01_08_423993	414	38	-	-	:
10_1101-2021_01_08_423993	414	39	BY	by	IN
10_1101-2021_01_08_423993	414	40	4.0	4.0	CD
10_1101-2021_01_08_423993	414	41	International	international	JJ
10_1101-2021_01_08_423993	414	42	licensemade	licensemade	NN
10_1101-2021_01_08_423993	414	43	available	available	JJ
10_1101-2021_01_08_423993	414	44	under	under	IN
10_1101-2021_01_08_423993	414	45	a	a	DT
10_1101-2021_01_08_423993	414	46	(	(	-LRB-
10_1101-2021_01_08_423993	414	47	which	which	WDT
10_1101-2021_01_08_423993	414	48	was	be	VBD
10_1101-2021_01_08_423993	414	49	not	not	RB
10_1101-2021_01_08_423993	414	50	certified	certify	VBN
10_1101-2021_01_08_423993	414	51	by	by	IN
10_1101-2021_01_08_423993	414	52	peer	peer	NN
10_1101-2021_01_08_423993	414	53	review	review	NN
10_1101-2021_01_08_423993	414	54	)	)	-RRB-
10_1101-2021_01_08_423993	414	55	is	be	VBZ
10_1101-2021_01_08_423993	414	56	the	the	DT
10_1101-2021_01_08_423993	414	57	author	author	NN
10_1101-2021_01_08_423993	414	58	/	/	SYM
10_1101-2021_01_08_423993	414	59	funder	funder	NN
10_1101-2021_01_08_423993	414	60	,	,	,
10_1101-2021_01_08_423993	414	61	who	who	WP
10_1101-2021_01_08_423993	414	62	has	have	VBZ
10_1101-2021_01_08_423993	414	63	granted	grant	VBN
10_1101-2021_01_08_423993	414	64	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	414	65	a	a	DT
10_1101-2021_01_08_423993	414	66	license	license	NN
10_1101-2021_01_08_423993	414	67	to	to	TO
10_1101-2021_01_08_423993	414	68	display	display	VB
10_1101-2021_01_08_423993	414	69	the	the	DT
10_1101-2021_01_08_423993	414	70	preprint	preprint	NN
10_1101-2021_01_08_423993	414	71	in	in	IN
10_1101-2021_01_08_423993	414	72	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	414	73	.	.	.
10_1101-2021_01_08_423993	415	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	415	2	is	be	VBZ
10_1101-2021_01_08_423993	415	3	The	the	DT
10_1101-2021_01_08_423993	415	4	copyright	copyright	NN
10_1101-2021_01_08_423993	415	5	holder	holder	NN
10_1101-2021_01_08_423993	415	6	for	for	IN
10_1101-2021_01_08_423993	415	7	this	this	DT
10_1101-2021_01_08_423993	415	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	415	9	version	version	NN
10_1101-2021_01_08_423993	415	10	posted	post	VBD
10_1101-2021_01_08_423993	415	11	January	January	NNP
10_1101-2021_01_08_423993	415	12	8	8	CD
10_1101-2021_01_08_423993	415	13	,	,	,
10_1101-2021_01_08_423993	415	14	2021	2021	CD
10_1101-2021_01_08_423993	415	15	.	.	.
10_1101-2021_01_08_423993	415	16	;	;	:
10_1101-2021_01_08_423993	415	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	415	18	:	:	:
10_1101-2021_01_08_423993	415	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	415	20	preprint	preprint	NN
10_1101-2021_01_08_423993	415	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	NN
10_1101-2021_01_08_423993	415	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	415	23	activity	activity	NN
10_1101-2021_01_08_423993	415	24	.	.	.
10_1101-2021_01_08_423993	416	1	J.	J.	NNP
10_1101-2021_01_08_423993	416	2	Biol	Biol	NNP
10_1101-2021_01_08_423993	416	3	.	.	.
10_1101-2021_01_08_423993	417	1	Chem	Chem	NNP
10_1101-2021_01_08_423993	417	2	.	.	.
10_1101-2021_01_08_423993	418	1	289	289	CD
10_1101-2021_01_08_423993	418	2	,	,	,
10_1101-2021_01_08_423993	418	3	7825–7834	7825–7834	CD
10_1101-2021_01_08_423993	418	4	.	.	.
10_1101-2021_01_08_423993	419	1	9	9	CD
10_1101-2021_01_08_423993	419	2	.	.	.
10_1101-2021_01_08_423993	420	1	Baddock	baddock	IN
10_1101-2021_01_08_423993	420	2	HT	HT	NNP
10_1101-2021_01_08_423993	420	3	,	,	,
10_1101-2021_01_08_423993	420	4	Yosaatmadja	Yosaatmadja	NNP
10_1101-2021_01_08_423993	420	5	Y	Y	NNP
10_1101-2021_01_08_423993	420	6	,	,	,
10_1101-2021_01_08_423993	420	7	Newman	Newman	NNP
10_1101-2021_01_08_423993	420	8	JA	JA	NNP
10_1101-2021_01_08_423993	420	9	,	,	,
10_1101-2021_01_08_423993	420	10	Schofield	Schofield	NNP
10_1101-2021_01_08_423993	420	11	CJ	CJ	NNP
10_1101-2021_01_08_423993	420	12	,	,	,
10_1101-2021_01_08_423993	420	13	Gileadi	Gileadi	NNP
10_1101-2021_01_08_423993	420	14	O	O	NNP
10_1101-2021_01_08_423993	420	15	&	&	CC
10_1101-2021_01_08_423993	420	16	McHugh	McHugh	NNP
10_1101-2021_01_08_423993	420	17	PJ	PJ	NNP
10_1101-2021_01_08_423993	420	18	(	(	-LRB-
10_1101-2021_01_08_423993	420	19	2020	2020	CD
10_1101-2021_01_08_423993	420	20	)	)	-RRB-
10_1101-2021_01_08_423993	420	21	The	the	DT
10_1101-2021_01_08_423993	420	22	SNM1A	SNM1A	NNP
10_1101-2021_01_08_423993	420	23	DNA	DNA	NNP
10_1101-2021_01_08_423993	420	24	Repair	Repair	NNP
10_1101-2021_01_08_423993	420	25	Nuclease	Nuclease	NNP
10_1101-2021_01_08_423993	420	26	.	.	.
10_1101-2021_01_08_423993	421	1	DNA	DNA	NNP
10_1101-2021_01_08_423993	421	2	Repair	Repair	NNP
10_1101-2021_01_08_423993	421	3	(	(	-LRB-
10_1101-2021_01_08_423993	421	4	Amst	Amst	NNP
10_1101-2021_01_08_423993	421	5	)	)	-RRB-
10_1101-2021_01_08_423993	421	6	.	.	.
10_1101-2021_01_08_423993	422	1	594	594	CD
10_1101-2021_01_08_423993	422	2	,	,	,
10_1101-2021_01_08_423993	422	3	102941	102941	CD
10_1101-2021_01_08_423993	422	4	.	.	.
10_1101-2021_01_08_423993	423	1	10	10	CD
10_1101-2021_01_08_423993	423	2	.	.	.
10_1101-2021_01_08_423993	424	1	Yan	Yan	NNP
10_1101-2021_01_08_423993	424	2	Y	Y	NNP
10_1101-2021_01_08_423993	424	3	,	,	,
10_1101-2021_01_08_423993	424	4	Akhter	Akhter	NNP
10_1101-2021_01_08_423993	424	5	S	S	NNP
10_1101-2021_01_08_423993	424	6	,	,	,
10_1101-2021_01_08_423993	424	7	Zhang	Zhang	NNP
10_1101-2021_01_08_423993	424	8	X	X	NNP
10_1101-2021_01_08_423993	424	9	&	&	CC
10_1101-2021_01_08_423993	424	10	Legerski	Legerski	NNP
10_1101-2021_01_08_423993	424	11	R	R	NNP
10_1101-2021_01_08_423993	424	12	(	(	-LRB-
10_1101-2021_01_08_423993	424	13	2010	2010	CD
10_1101-2021_01_08_423993	424	14	)	)	-RRB-
10_1101-2021_01_08_423993	424	15	The	the	DT
10_1101-2021_01_08_423993	424	16	multifunctional	multifunctional	JJ
10_1101-2021_01_08_423993	424	17	SNM1	SNM1	NNP
10_1101-2021_01_08_423993	424	18	gene	gene	NN
10_1101-2021_01_08_423993	424	19	family	family	NN
10_1101-2021_01_08_423993	424	20	:	:	:
10_1101-2021_01_08_423993	424	21	not	not	RB
10_1101-2021_01_08_423993	424	22	just	just	RB
10_1101-2021_01_08_423993	424	23	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	424	24	.	.	.
10_1101-2021_01_08_423993	425	1	Future	Future	NNP
10_1101-2021_01_08_423993	425	2	Oncol	Oncol	NNP
10_1101-2021_01_08_423993	425	3	.	.	.
10_1101-2021_01_08_423993	426	1	6	6	CD
10_1101-2021_01_08_423993	426	2	,	,	,
10_1101-2021_01_08_423993	426	3	1015–1029	1015–1029	CD
10_1101-2021_01_08_423993	426	4	.	.	.
10_1101-2021_01_08_423993	427	1	11	11	CD
10_1101-2021_01_08_423993	427	2	.	.	.
10_1101-2021_01_08_423993	428	1	Wang	Wang	NNP
10_1101-2021_01_08_423993	428	2	AT	AT	NNP
10_1101-2021_01_08_423993	428	3	,	,	,
10_1101-2021_01_08_423993	428	4	Sengerova	Sengerova	NNP
10_1101-2021_01_08_423993	428	5	B	B	NNP
10_1101-2021_01_08_423993	428	6	,	,	,
10_1101-2021_01_08_423993	428	7	Cattell	Cattell	NNP
10_1101-2021_01_08_423993	428	8	E	E	NNP
10_1101-2021_01_08_423993	428	9	,	,	,
10_1101-2021_01_08_423993	428	10	Inagawa	Inagawa	NNP
10_1101-2021_01_08_423993	428	11	T	T	NNP
10_1101-2021_01_08_423993	428	12	,	,	,
10_1101-2021_01_08_423993	428	13	Hartley	Hartley	NNP
10_1101-2021_01_08_423993	428	14	JM	JM	NNP
10_1101-2021_01_08_423993	428	15	,	,	,
10_1101-2021_01_08_423993	428	16	Kiakos	Kiakos	NNP
10_1101-2021_01_08_423993	428	17	K	K	NNP
10_1101-2021_01_08_423993	428	18	,	,	,
10_1101-2021_01_08_423993	428	19	Burgess	Burgess	NNP
10_1101-2021_01_08_423993	428	20	-	-	HYPH
10_1101-2021_01_08_423993	428	21	Brown	Brown	NNP
10_1101-2021_01_08_423993	428	22	NA	NA	NNP
10_1101-2021_01_08_423993	428	23	,	,	,
10_1101-2021_01_08_423993	428	24	P	p	NN
10_1101-2021_01_08_423993	428	25	SL	sl	NN
10_1101-2021_01_08_423993	428	26	,	,	,
10_1101-2021_01_08_423993	428	27	H	H	NNP
10_1101-2021_01_08_423993	428	28	EJ	EJ	NNP
10_1101-2021_01_08_423993	428	29	,	,	,
10_1101-2021_01_08_423993	428	30	Schofield	Schofield	NNP
10_1101-2021_01_08_423993	428	31	CJ	CJ	NNP
10_1101-2021_01_08_423993	428	32	,	,	,
10_1101-2021_01_08_423993	428	33	Gileadi	Gileadi	NNP
10_1101-2021_01_08_423993	428	34	O	O	NNP
10_1101-2021_01_08_423993	428	35	,	,	,
10_1101-2021_01_08_423993	428	36	Hartley	Hartley	NNP
10_1101-2021_01_08_423993	428	37	JA	JA	NNP
10_1101-2021_01_08_423993	428	38	&	&	CC
10_1101-2021_01_08_423993	428	39	Mchugh	Mchugh	NNP
10_1101-2021_01_08_423993	428	40	PJ	PJ	NNP
10_1101-2021_01_08_423993	428	41	(	(	-LRB-
10_1101-2021_01_08_423993	428	42	20AD	20ad	CD
10_1101-2021_01_08_423993	428	43	)	)	-RRB-
10_1101-2021_01_08_423993	428	44	Human	human	JJ
10_1101-2021_01_08_423993	428	45	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	428	46	and	and	CC
10_1101-2021_01_08_423993	428	47	XPF	xpf	NN
10_1101-2021_01_08_423993	428	48	–	–	:
10_1101-2021_01_08_423993	428	49	ERCC1	ERCC1	NNS
10_1101-2021_01_08_423993	428	50	collaborate	collaborate	VBP
10_1101-2021_01_08_423993	428	51	to	to	TO
10_1101-2021_01_08_423993	428	52	initiate	initiate	VB
10_1101-2021_01_08_423993	428	53	DNA	DNA	NNP
10_1101-2021_01_08_423993	428	54	interstrand	interstrand	NNP
10_1101-2021_01_08_423993	428	55	cross	cross	JJ
10_1101-2021_01_08_423993	428	56	-	-	JJ
10_1101-2021_01_08_423993	428	57	link	link	JJ
10_1101-2021_01_08_423993	428	58	repair	repair	NN
10_1101-2021_01_08_423993	428	59	.	.	.
10_1101-2021_01_08_423993	429	1	Genes	Genes	NNP
10_1101-2021_01_08_423993	429	2	Dev	Dev	NNP
10_1101-2021_01_08_423993	429	3	.	.	.
10_1101-2021_01_08_423993	430	1	25	25	CD
10_1101-2021_01_08_423993	430	2	,	,	,
10_1101-2021_01_08_423993	430	3	1859	1859	CD
10_1101-2021_01_08_423993	430	4	–	–	:
10_1101-2021_01_08_423993	430	5	1870	1870	CD
10_1101-2021_01_08_423993	430	6	.	.	.
10_1101-2021_01_08_423993	431	1	12	12	CD
10_1101-2021_01_08_423993	431	2	.	.	.
10_1101-2021_01_08_423993	432	1	Lenain	Lenain	NNP
10_1101-2021_01_08_423993	432	2	C	C	NNP
10_1101-2021_01_08_423993	432	3	,	,	,
10_1101-2021_01_08_423993	432	4	Bauwens	Bauwens	NNP
10_1101-2021_01_08_423993	432	5	S	S	NNP
10_1101-2021_01_08_423993	432	6	,	,	,
10_1101-2021_01_08_423993	432	7	Amiard	Amiard	NNP
10_1101-2021_01_08_423993	432	8	S	S	NNP
10_1101-2021_01_08_423993	432	9	,	,	,
10_1101-2021_01_08_423993	432	10	Brunori	Brunori	NNP
10_1101-2021_01_08_423993	432	11	M	M	NNP
10_1101-2021_01_08_423993	432	12	,	,	,
10_1101-2021_01_08_423993	432	13	Giraud	Giraud	NNP
10_1101-2021_01_08_423993	432	14	-	-	HYPH
10_1101-2021_01_08_423993	432	15	Panis	Panis	NNP
10_1101-2021_01_08_423993	432	16	MJ	MJ	NNP
10_1101-2021_01_08_423993	432	17	&	&	CC
10_1101-2021_01_08_423993	432	18	Gilson	Gilson	NNP
10_1101-2021_01_08_423993	432	19	E	E	NNP
10_1101-2021_01_08_423993	432	20	(	(	-LRB-
10_1101-2021_01_08_423993	432	21	2006	2006	CD
10_1101-2021_01_08_423993	432	22	)	)	-RRB-
10_1101-2021_01_08_423993	432	23	The	the	DT
10_1101-2021_01_08_423993	432	24	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	432	25	5′	5′	CD
10_1101-2021_01_08_423993	432	26	Exonuclease	Exonuclease	NNP
10_1101-2021_01_08_423993	432	27	Functions	Functions	NNPS
10_1101-2021_01_08_423993	432	28	Together	together	RB
10_1101-2021_01_08_423993	432	29	with	with	IN
10_1101-2021_01_08_423993	432	30	TRF2	TRF2	NNP
10_1101-2021_01_08_423993	432	31	to	to	IN
10_1101-2021_01_08_423993	432	32	Protect	Protect	NNP
10_1101-2021_01_08_423993	432	33	Telomeres	Telomeres	NNP
10_1101-2021_01_08_423993	432	34	from	from	IN
10_1101-2021_01_08_423993	432	35	DNA	DNA	NNP
10_1101-2021_01_08_423993	432	36	Repair	Repair	NNP
10_1101-2021_01_08_423993	432	37	.	.	.
10_1101-2021_01_08_423993	433	1	Curr	curr	UH
10_1101-2021_01_08_423993	433	2	.	.	.
10_1101-2021_01_08_423993	434	1	Biol	Biol	NNP
10_1101-2021_01_08_423993	434	2	.	.	.
10_1101-2021_01_08_423993	435	1	16	16	CD
10_1101-2021_01_08_423993	435	2	,	,	,
10_1101-2021_01_08_423993	435	3	1303–1310	1303–1310	CD
10_1101-2021_01_08_423993	435	4	.	.	.
10_1101-2021_01_08_423993	436	1	13	13	CD
10_1101-2021_01_08_423993	436	2	.	.	.
10_1101-2021_01_08_423993	436	3	van	van	NNP
10_1101-2021_01_08_423993	436	4	Overbeek	Overbeek	NNP
10_1101-2021_01_08_423993	436	5	M	M	NNP
10_1101-2021_01_08_423993	436	6	&	&	CC
10_1101-2021_01_08_423993	436	7	de	de	NNP
10_1101-2021_01_08_423993	436	8	Lange	Lange	NNP
10_1101-2021_01_08_423993	436	9	T	T	NNP
10_1101-2021_01_08_423993	436	10	(	(	-LRB-
10_1101-2021_01_08_423993	436	11	2006	2006	CD
10_1101-2021_01_08_423993	436	12	)	)	-RRB-
10_1101-2021_01_08_423993	436	13	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	436	14	,	,	,
10_1101-2021_01_08_423993	436	15	an	an	DT
10_1101-2021_01_08_423993	436	16	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	436	17	-	-	HYPH
10_1101-2021_01_08_423993	436	18	Related	relate	VBN
10_1101-2021_01_08_423993	436	19	Nuclease	Nuclease	NNP
10_1101-2021_01_08_423993	436	20	,	,	,
10_1101-2021_01_08_423993	436	21	Interacts	Interacts	NNPS
10_1101-2021_01_08_423993	436	22	with	with	IN
10_1101-2021_01_08_423993	436	23	TRF2	TRF2	NNP
10_1101-2021_01_08_423993	436	24	and	and	CC
10_1101-2021_01_08_423993	436	25	Protects	Protects	NNP
10_1101-2021_01_08_423993	436	26	Human	Human	NNP
10_1101-2021_01_08_423993	436	27	Telomeres	Telomeres	NNPS
10_1101-2021_01_08_423993	436	28	in	in	IN
10_1101-2021_01_08_423993	436	29	S	S	NNP
10_1101-2021_01_08_423993	436	30	Phase	Phase	NNP
10_1101-2021_01_08_423993	436	31	.	.	.
10_1101-2021_01_08_423993	437	1	Curr	curr	UH
10_1101-2021_01_08_423993	437	2	.	.	.
10_1101-2021_01_08_423993	438	1	Biol	Biol	NNP
10_1101-2021_01_08_423993	438	2	.	.	.
10_1101-2021_01_08_423993	439	1	16	16	CD
10_1101-2021_01_08_423993	439	2	,	,	,
10_1101-2021_01_08_423993	439	3	1295–1302	1295–1302	CD
10_1101-2021_01_08_423993	439	4	.	.	.
10_1101-2021_01_08_423993	440	1	14	14	CD
10_1101-2021_01_08_423993	440	2	.	.	.
10_1101-2021_01_08_423993	441	1	Demuth	Demuth	NNP
10_1101-2021_01_08_423993	441	2	I	I	NNP
10_1101-2021_01_08_423993	441	3	,	,	,
10_1101-2021_01_08_423993	441	4	Digweed	Digweed	NNP
10_1101-2021_01_08_423993	441	5	M	M	NNP
10_1101-2021_01_08_423993	441	6	&	&	CC
10_1101-2021_01_08_423993	441	7	Concannon	Concannon	NNP
10_1101-2021_01_08_423993	441	8	P	P	NNP
10_1101-2021_01_08_423993	441	9	(	(	-LRB-
10_1101-2021_01_08_423993	441	10	2004	2004	CD
10_1101-2021_01_08_423993	441	11	)	)	-RRB-
10_1101-2021_01_08_423993	441	12	Human	human	NN
10_1101-2021_01_08_423993	441	13	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	441	14	is	be	VBZ
10_1101-2021_01_08_423993	441	15	required	require	VBN
10_1101-2021_01_08_423993	441	16	for	for	IN
10_1101-2021_01_08_423993	441	17	normal	normal	JJ
10_1101-2021_01_08_423993	441	18	cellular	cellular	JJ
10_1101-2021_01_08_423993	441	19	response	response	NN
10_1101-2021_01_08_423993	441	20	to	to	IN
10_1101-2021_01_08_423993	441	21	both	both	DT
10_1101-2021_01_08_423993	441	22	DNA	DNA	NNP
10_1101-2021_01_08_423993	441	23	interstrand	interstrand	NNP
10_1101-2021_01_08_423993	441	24	crosslink	crosslink	NN
10_1101-2021_01_08_423993	441	25	-	-	HYPH
10_1101-2021_01_08_423993	441	26	inducing	induce	VBG
10_1101-2021_01_08_423993	441	27	agents	agent	NNS
10_1101-2021_01_08_423993	441	28	and	and	CC
10_1101-2021_01_08_423993	441	29	ionizing	ionize	VBG
10_1101-2021_01_08_423993	441	30	radiation	radiation	NN
10_1101-2021_01_08_423993	441	31	.	.	.
10_1101-2021_01_08_423993	442	1	Oncogene	oncogene	NN
10_1101-2021_01_08_423993	442	2	23	23	CD
10_1101-2021_01_08_423993	442	3	,	,	,
10_1101-2021_01_08_423993	442	4	8611–8618	8611–8618	CD
10_1101-2021_01_08_423993	442	5	.	.	.
10_1101-2021_01_08_423993	443	1	15	15	CD
10_1101-2021_01_08_423993	443	2	.	.	.
10_1101-2021_01_08_423993	444	1	Sengerová	Sengerová	NNP
10_1101-2021_01_08_423993	444	2	B	B	NNP
10_1101-2021_01_08_423993	444	3	,	,	,
10_1101-2021_01_08_423993	444	4	Allerston	Allerston	NNP
10_1101-2021_01_08_423993	444	5	CK	CK	NNP
10_1101-2021_01_08_423993	444	6	,	,	,
10_1101-2021_01_08_423993	444	7	Abu	Abu	NNP
10_1101-2021_01_08_423993	444	8	M	M	NNP
10_1101-2021_01_08_423993	444	9	,	,	,
10_1101-2021_01_08_423993	444	10	Lee	Lee	NNP
10_1101-2021_01_08_423993	444	11	SY	SY	NNP
10_1101-2021_01_08_423993	444	12	,	,	,
10_1101-2021_01_08_423993	444	13	Hartley	Hartley	NNP
10_1101-2021_01_08_423993	444	14	J	J	NNP
10_1101-2021_01_08_423993	444	15	,	,	,
10_1101-2021_01_08_423993	444	16	Kiakos	Kiakos	NNP
10_1101-2021_01_08_423993	444	17	K	K	NNP
10_1101-2021_01_08_423993	444	18	,	,	,
10_1101-2021_01_08_423993	444	19	Schofield	Schofield	NNP
10_1101-2021_01_08_423993	444	20	CJ	CJ	NNP
10_1101-2021_01_08_423993	444	21	,	,	,
10_1101-2021_01_08_423993	444	22	Hartley	Hartley	NNP
10_1101-2021_01_08_423993	444	23	JA	JA	NNP
10_1101-2021_01_08_423993	444	24	,	,	,
10_1101-2021_01_08_423993	444	25	Gileadi	Gileadi	NNP
10_1101-2021_01_08_423993	444	26	O	O	NNP
10_1101-2021_01_08_423993	444	27	&	&	CC
10_1101-2021_01_08_423993	444	28	McHugh	McHugh	NNP
10_1101-2021_01_08_423993	444	29	PJ	PJ	NNP
10_1101-2021_01_08_423993	444	30	(	(	-LRB-
10_1101-2021_01_08_423993	444	31	2012	2012	CD
10_1101-2021_01_08_423993	444	32	)	)	-RRB-
10_1101-2021_01_08_423993	444	33	Characterization	characterization	NN
10_1101-2021_01_08_423993	444	34	of	of	IN
10_1101-2021_01_08_423993	444	35	the	the	DT
10_1101-2021_01_08_423993	444	36	human	human	NN
10_1101-2021_01_08_423993	444	37	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	444	38	and	and	CC
10_1101-2021_01_08_423993	444	39	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	444	40	/	/	SYM
10_1101-2021_01_08_423993	444	41	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	444	42	DNA	DNA	NNP
10_1101-2021_01_08_423993	444	43	repair	repair	NN
10_1101-2021_01_08_423993	444	44	exonucleases	exonuclease	NNS
10_1101-2021_01_08_423993	444	45	.	.	.
10_1101-2021_01_08_423993	445	1	J.	J.	NNP
10_1101-2021_01_08_423993	445	2	Biol	Biol	NNP
10_1101-2021_01_08_423993	445	3	.	.	.
10_1101-2021_01_08_423993	446	1	Chem	Chem	NNP
10_1101-2021_01_08_423993	446	2	.	.	.
10_1101-2021_01_08_423993	447	1	287	287	CD
10_1101-2021_01_08_423993	447	2	,	,	,
10_1101-2021_01_08_423993	447	3	26254–26267	26254–26267	CD
10_1101-2021_01_08_423993	447	4	.	.	.
10_1101-2021_01_08_423993	448	1	16	16	CD
10_1101-2021_01_08_423993	448	2	.	.	.
10_1101-2021_01_08_423993	449	1	Mansilla	Mansilla	NNP
10_1101-2021_01_08_423993	449	2	-	-	HYPH
10_1101-2021_01_08_423993	449	3	Soto	Soto	NNP
10_1101-2021_01_08_423993	449	4	J	J	NNP
10_1101-2021_01_08_423993	449	5	&	&	CC
10_1101-2021_01_08_423993	449	6	Cortes	Cortes	NNP
10_1101-2021_01_08_423993	449	7	P	P	NNP
10_1101-2021_01_08_423993	449	8	(	(	-LRB-
10_1101-2021_01_08_423993	449	9	2003	2003	CD
10_1101-2021_01_08_423993	449	10	)	)	-RRB-
10_1101-2021_01_08_423993	449	11	VDJ	VDJ	NNP
10_1101-2021_01_08_423993	449	12	recombination	recombination	NN
10_1101-2021_01_08_423993	449	13	:	:	:
10_1101-2021_01_08_423993	449	14	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	449	15	and	and	CC
10_1101-2021_01_08_423993	449	16	its	-PRON-	PRP$
10_1101-2021_01_08_423993	449	17	in	in	IN
10_1101-2021_01_08_423993	449	18	vivo	vivo	NNP
10_1101-2021_01_08_423993	449	19	role	role	NN
10_1101-2021_01_08_423993	449	20	in	in	IN
10_1101-2021_01_08_423993	449	21	hairpin	hairpin	NNP
10_1101-2021_01_08_423993	449	22	opening	opening	NN
10_1101-2021_01_08_423993	449	23	.	.	.
10_1101-2021_01_08_423993	450	1	J.	J.	NNP
10_1101-2021_01_08_423993	450	2	Exp	Exp	NNP
10_1101-2021_01_08_423993	450	3	.	.	.
10_1101-2021_01_08_423993	451	1	Med	Med	NNP
10_1101-2021_01_08_423993	451	2	.	.	.
10_1101-2021_01_08_423993	452	1	197	197	CD
10_1101-2021_01_08_423993	452	2	,	,	,
10_1101-2021_01_08_423993	452	3	543–547	543–547	CD
10_1101-2021_01_08_423993	452	4	.	.	.
10_1101-2021_01_08_423993	453	1	17	17	CD
10_1101-2021_01_08_423993	453	2	.	.	.
10_1101-2021_01_08_423993	454	1	Ma	Ma	NNP
10_1101-2021_01_08_423993	454	2	Y	Y	NNP
10_1101-2021_01_08_423993	454	3	,	,	,
10_1101-2021_01_08_423993	454	4	Pannicke	Pannicke	NNP
10_1101-2021_01_08_423993	454	5	U	U	NNP
10_1101-2021_01_08_423993	454	6	,	,	,
10_1101-2021_01_08_423993	454	7	Schwarz	Schwarz	NNP
10_1101-2021_01_08_423993	454	8	K	K	NNP
10_1101-2021_01_08_423993	454	9	&	&	CC
10_1101-2021_01_08_423993	454	10	Lieber	Lieber	NNP
10_1101-2021_01_08_423993	454	11	MR	MR	NNP
10_1101-2021_01_08_423993	454	12	(	(	-LRB-
10_1101-2021_01_08_423993	454	13	2002	2002	CD
10_1101-2021_01_08_423993	454	14	)	)	-RRB-
10_1101-2021_01_08_423993	454	15	Hairpin	hairpin	VB
10_1101-2021_01_08_423993	454	16	opening	opening	NN
10_1101-2021_01_08_423993	454	17	and	and	CC
10_1101-2021_01_08_423993	454	18	overhang	overhang	NN
10_1101-2021_01_08_423993	454	19	processing	processing	NN
10_1101-2021_01_08_423993	454	20	by	by	IN
10_1101-2021_01_08_423993	454	21	an	an	DT
10_1101-2021_01_08_423993	454	22	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	454	23	/	/	SYM
10_1101-2021_01_08_423993	454	24	DNA	DNA	NNP
10_1101-2021_01_08_423993	454	25	-	-	HYPH
10_1101-2021_01_08_423993	454	26	dependent	dependent	JJ
10_1101-2021_01_08_423993	454	27	protein	protein	NN
10_1101-2021_01_08_423993	454	28	kinase	kinase	VBD
10_1101-2021_01_08_423993	454	29	complex	complex	NN
10_1101-2021_01_08_423993	454	30	in	in	IN
10_1101-2021_01_08_423993	454	31	nonhomologous	nonhomologous	JJ
10_1101-2021_01_08_423993	454	32	end	end	NN
10_1101-2021_01_08_423993	454	33	joining	joining	NN
10_1101-2021_01_08_423993	454	34	and	and	CC
10_1101-2021_01_08_423993	454	35	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	454	36	recombination	recombination	NN
10_1101-2021_01_08_423993	454	37	.	.	.
10_1101-2021_01_08_423993	455	1	Cell	cell	NN
10_1101-2021_01_08_423993	455	2	108	108	CD
10_1101-2021_01_08_423993	455	3	,	,	,
10_1101-2021_01_08_423993	455	4	781–794	781–794	CD
10_1101-2021_01_08_423993	455	5	.	.	.
10_1101-2021_01_08_423993	456	1	18	18	CD
10_1101-2021_01_08_423993	456	2	.	.	.
10_1101-2021_01_08_423993	457	1	Ma	Ma	NNP
10_1101-2021_01_08_423993	457	2	Y	Y	NNP
10_1101-2021_01_08_423993	457	3	,	,	,
10_1101-2021_01_08_423993	457	4	Schwarz	Schwarz	NNP
10_1101-2021_01_08_423993	457	5	K	K	NNP
10_1101-2021_01_08_423993	457	6	&	&	CC
10_1101-2021_01_08_423993	457	7	Lieber	Lieber	NNP
10_1101-2021_01_08_423993	457	8	MR	MR	NNP
10_1101-2021_01_08_423993	457	9	(	(	-LRB-
10_1101-2021_01_08_423993	457	10	2005	2005	CD
10_1101-2021_01_08_423993	457	11	)	)	-RRB-
10_1101-2021_01_08_423993	457	12	The	the	DT
10_1101-2021_01_08_423993	457	13	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	457	14	:	:	:
10_1101-2021_01_08_423993	457	15	DNA	dna	NN
10_1101-2021_01_08_423993	457	16	-	-	HYPH
10_1101-2021_01_08_423993	457	17	PKcs	pkcs	NN
10_1101-2021_01_08_423993	457	18	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	457	19	cleaves	cleave	VBZ
10_1101-2021_01_08_423993	457	20	DNA	dna	NN
10_1101-2021_01_08_423993	457	21	loops	loop	NNS
10_1101-2021_01_08_423993	457	22	,	,	,
10_1101-2021_01_08_423993	457	23	flaps	flap	NNS
10_1101-2021_01_08_423993	457	24	,	,	,
10_1101-2021_01_08_423993	457	25	and	and	CC
10_1101-2021_01_08_423993	457	26	gaps	gap	NNS
10_1101-2021_01_08_423993	457	27	.	.	.
10_1101-2021_01_08_423993	458	1	DNA	DNA	NNP
10_1101-2021_01_08_423993	458	2	Repair	Repair	NNP
10_1101-2021_01_08_423993	458	3	(	(	-LRB-
10_1101-2021_01_08_423993	458	4	Amst	Amst	NNP
10_1101-2021_01_08_423993	458	5	)	)	-RRB-
10_1101-2021_01_08_423993	458	6	.	.	.
10_1101-2021_01_08_423993	459	1	4	4	CD
10_1101-2021_01_08_423993	459	2	,	,	,
10_1101-2021_01_08_423993	459	3	845–851	845–851	CD
10_1101-2021_01_08_423993	459	4	.	.	.
10_1101-2021_01_08_423993	460	1	19	19	CD
10_1101-2021_01_08_423993	460	2	.	.	.
10_1101-2021_01_08_423993	461	1	Moshous	moshous	JJ
10_1101-2021_01_08_423993	461	2	D	D	NNP
10_1101-2021_01_08_423993	461	3	,	,	,
10_1101-2021_01_08_423993	461	4	Callebaut	Callebaut	NNP
10_1101-2021_01_08_423993	461	5	I	I	NNP
10_1101-2021_01_08_423993	461	6	,	,	,
10_1101-2021_01_08_423993	461	7	De	De	NNP
10_1101-2021_01_08_423993	461	8	Chasseval	Chasseval	NNP
10_1101-2021_01_08_423993	461	9	R	R	NNP
10_1101-2021_01_08_423993	461	10	,	,	,
10_1101-2021_01_08_423993	461	11	Corneo	Corneo	NNP
10_1101-2021_01_08_423993	461	12	B	B	NNP
10_1101-2021_01_08_423993	461	13	,	,	,
10_1101-2021_01_08_423993	461	14	Cavazzana	Cavazzana	NNP
10_1101-2021_01_08_423993	461	15	-	-	HYPH
10_1101-2021_01_08_423993	461	16	Calvo	Calvo	NNP
10_1101-2021_01_08_423993	461	17	M	M	NNP
10_1101-2021_01_08_423993	461	18	,	,	,
10_1101-2021_01_08_423993	461	19	Le	Le	NNP
10_1101-2021_01_08_423993	461	20	Deist	Deist	NNP
10_1101-2021_01_08_423993	461	21	F	F	NNP
10_1101-2021_01_08_423993	461	22	,	,	,
10_1101-2021_01_08_423993	461	23	Tezcan	Tezcan	NNP
10_1101-2021_01_08_423993	461	24	I	-PRON-	PRP
10_1101-2021_01_08_423993	461	25	,	,	,
10_1101-2021_01_08_423993	461	26	Sanal	Sanal	NNP
10_1101-2021_01_08_423993	461	27	O	o	UH
10_1101-2021_01_08_423993	461	28	,	,	,
10_1101-2021_01_08_423993	461	29	Bertrand	Bertrand	NNP
10_1101-2021_01_08_423993	461	30	Y	Y	NNP
10_1101-2021_01_08_423993	461	31	,	,	,
10_1101-2021_01_08_423993	461	32	Philippe	Philippe	NNP
10_1101-2021_01_08_423993	461	33	N	N	NNP
10_1101-2021_01_08_423993	461	34	,	,	,
10_1101-2021_01_08_423993	461	35	Fischer	Fischer	NNP
10_1101-2021_01_08_423993	461	36	A	A	NNP
10_1101-2021_01_08_423993	461	37	&	&	CC
10_1101-2021_01_08_423993	461	38	De	De	NNP
10_1101-2021_01_08_423993	461	39	Villartay	Villartay	NNP
10_1101-2021_01_08_423993	461	40	JP	JP	NNP
10_1101-2021_01_08_423993	461	41	(	(	-LRB-
10_1101-2021_01_08_423993	461	42	2001	2001	CD
10_1101-2021_01_08_423993	461	43	)	)	-RRB-
10_1101-2021_01_08_423993	461	44	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	461	45	,	,	,
10_1101-2021_01_08_423993	461	46	a	a	DT
10_1101-2021_01_08_423993	461	47	novel	novel	JJ
10_1101-2021_01_08_423993	461	48	DNA	dna	NN
10_1101-2021_01_08_423993	461	49	double	double	JJ
10_1101-2021_01_08_423993	461	50	-	-	HYPH
10_1101-2021_01_08_423993	461	51	strand	strand	NN
10_1101-2021_01_08_423993	461	52	break	break	NN
10_1101-2021_01_08_423993	461	53	repair	repair	NN
10_1101-2021_01_08_423993	461	54	/	/	SYM
10_1101-2021_01_08_423993	461	55	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	461	56	recombination	recombination	NN
10_1101-2021_01_08_423993	461	57	protein	protein	NN
10_1101-2021_01_08_423993	461	58	,	,	,
10_1101-2021_01_08_423993	461	59	is	be	VBZ
10_1101-2021_01_08_423993	461	60	mutated	mutate	VBN
10_1101-2021_01_08_423993	461	61	in	in	IN
10_1101-2021_01_08_423993	461	62	human	human	JJ
10_1101-2021_01_08_423993	461	63	severe	severe	JJ
10_1101-2021_01_08_423993	461	64	combined	combined	JJ
10_1101-2021_01_08_423993	461	65	immune	immune	JJ
10_1101-2021_01_08_423993	461	66	deficiency	deficiency	NN
10_1101-2021_01_08_423993	461	67	.	.	.
10_1101-2021_01_08_423993	462	1	Cell	cell	NN
10_1101-2021_01_08_423993	462	2	105	105	CD
10_1101-2021_01_08_423993	462	3	,	,	,
10_1101-2021_01_08_423993	462	4	177–186	177–186	CD
10_1101-2021_01_08_423993	462	5	.	.	.
10_1101-2021_01_08_423993	463	1	20	20	CD
10_1101-2021_01_08_423993	463	2	.	.	.
10_1101-2021_01_08_423993	464	1	Lieber	Lieber	NNP
10_1101-2021_01_08_423993	464	2	MR	MR	NNP
10_1101-2021_01_08_423993	464	3	(	(	-LRB-
10_1101-2021_01_08_423993	464	4	2011	2011	CD
10_1101-2021_01_08_423993	464	5	)	)	-RRB-
10_1101-2021_01_08_423993	464	6	The	the	DT
10_1101-2021_01_08_423993	464	7	mechanism	mechanism	NN
10_1101-2021_01_08_423993	464	8	of	of	IN
10_1101-2021_01_08_423993	464	9	DSB	DSB	NNP
10_1101-2021_01_08_423993	464	10	repair	repair	NN
10_1101-2021_01_08_423993	464	11	by	by	IN
10_1101-2021_01_08_423993	464	12	the	the	DT
10_1101-2021_01_08_423993	464	13	NHEJ	NHEJ	NNP
10_1101-2021_01_08_423993	464	14	.	.	.
10_1101-2021_01_08_423993	465	1	Annu	Annu	NNP
10_1101-2021_01_08_423993	465	2	.	.	.
10_1101-2021_01_08_423993	466	1	Rev.	Rev.	NNP
10_1101-2021_01_08_423993	467	1	Biochem	Biochem	NNP
10_1101-2021_01_08_423993	467	2	.	.	.
10_1101-2021_01_08_423993	468	1	79	79	CD
10_1101-2021_01_08_423993	468	2	,	,	,
10_1101-2021_01_08_423993	468	3	181–211	181–211	CD
10_1101-2021_01_08_423993	468	4	.	.	.
10_1101-2021_01_08_423993	469	1	21	21	CD
10_1101-2021_01_08_423993	469	2	.	.	.
10_1101-2021_01_08_423993	470	1	Gu	Gu	NNP
10_1101-2021_01_08_423993	470	2	J	J	NNP
10_1101-2021_01_08_423993	470	3	,	,	,
10_1101-2021_01_08_423993	470	4	Li	Li	NNP
10_1101-2021_01_08_423993	470	5	S	S	NNP
10_1101-2021_01_08_423993	470	6	,	,	,
10_1101-2021_01_08_423993	470	7	Zhang	Zhang	NNP
10_1101-2021_01_08_423993	470	8	X	X	NNP
10_1101-2021_01_08_423993	470	9	,	,	,
10_1101-2021_01_08_423993	470	10	Wang	Wang	NNP
10_1101-2021_01_08_423993	470	11	LC	LC	NNP
10_1101-2021_01_08_423993	470	12	,	,	,
10_1101-2021_01_08_423993	470	13	Niewolik	Niewolik	NNP
10_1101-2021_01_08_423993	470	14	D	D	NNP
10_1101-2021_01_08_423993	470	15	,	,	,
10_1101-2021_01_08_423993	470	16	Schwarz	Schwarz	NNP
10_1101-2021_01_08_423993	470	17	K	K	NNP
10_1101-2021_01_08_423993	470	18	,	,	,
10_1101-2021_01_08_423993	470	19	Legerski	Legerski	NNP
10_1101-2021_01_08_423993	470	20	RJ	RJ	NNP
10_1101-2021_01_08_423993	470	21	,	,	,
10_1101-2021_01_08_423993	470	22	Zandi	Zandi	NNP
10_1101-2021_01_08_423993	470	23	E	E	NNP
10_1101-2021_01_08_423993	470	24	&	&	CC
10_1101-2021_01_08_423993	470	25	Lieber	Lieber	NNP
10_1101-2021_01_08_423993	470	26	MR	MR	NNP
10_1101-2021_01_08_423993	470	27	(	(	-LRB-
10_1101-2021_01_08_423993	470	28	2010	2010	CD
10_1101-2021_01_08_423993	470	29	)	)	-RRB-
10_1101-2021_01_08_423993	470	30	DNA	dna	NN
10_1101-2021_01_08_423993	470	31	-	-	HYPH
10_1101-2021_01_08_423993	470	32	PKcs	PKcs	NNP
10_1101-2021_01_08_423993	470	33	regulates	regulate	VBZ
10_1101-2021_01_08_423993	470	34	a	a	DT
10_1101-2021_01_08_423993	470	35	single	single	JJ
10_1101-2021_01_08_423993	470	36	-	-	HYPH
10_1101-2021_01_08_423993	470	37	stranded	strand	VBN
10_1101-2021_01_08_423993	470	38	DNA	dna	NN
10_1101-2021_01_08_423993	470	39	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	470	40	activity	activity	NN
10_1101-2021_01_08_423993	470	41	of	of	IN
10_1101-2021_01_08_423993	470	42	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	470	43	.	.	.
10_1101-2021_01_08_423993	471	1	DNA	DNA	NNP
10_1101-2021_01_08_423993	471	2	Repair	Repair	NNP
10_1101-2021_01_08_423993	471	3	(	(	-LRB-
10_1101-2021_01_08_423993	471	4	Amst	Amst	NNP
10_1101-2021_01_08_423993	471	5	)	)	-RRB-
10_1101-2021_01_08_423993	471	6	.	.	.
10_1101-2021_01_08_423993	472	1	9	9	CD
10_1101-2021_01_08_423993	472	2	,	,	,
10_1101-2021_01_08_423993	472	3	429–437	429–437	CD
10_1101-2021_01_08_423993	472	4	.	.	.
10_1101-2021_01_08_423993	473	1	22	22	CD
10_1101-2021_01_08_423993	473	2	.	.	.
10_1101-2021_01_08_423993	474	1	Srivastava	Srivastava	NNP
10_1101-2021_01_08_423993	474	2	M	M	NNP
10_1101-2021_01_08_423993	474	3	&	&	CC
10_1101-2021_01_08_423993	474	4	Raghavan	Raghavan	NNP
10_1101-2021_01_08_423993	474	5	SC	SC	NNP
10_1101-2021_01_08_423993	474	6	(	(	-LRB-
10_1101-2021_01_08_423993	474	7	2015	2015	CD
10_1101-2021_01_08_423993	474	8	)	)	-RRB-
10_1101-2021_01_08_423993	474	9	DNA	dna	NN
10_1101-2021_01_08_423993	474	10	double	double	JJ
10_1101-2021_01_08_423993	474	11	-	-	HYPH
10_1101-2021_01_08_423993	474	12	strand	strand	NN
10_1101-2021_01_08_423993	474	13	break	break	NN
10_1101-2021_01_08_423993	474	14	repair	repair	NN
10_1101-2021_01_08_423993	474	15	inhibitors	inhibitor	NNS
10_1101-2021_01_08_423993	474	16	as	as	IN
10_1101-2021_01_08_423993	474	17	cancer	cancer	NN
10_1101-2021_01_08_423993	474	18	therapeutics	therapeutic	NNS
10_1101-2021_01_08_423993	474	19	.	.	.
10_1101-2021_01_08_423993	475	1	Chem	Chem	NNP
10_1101-2021_01_08_423993	475	2	.	.	.
10_1101-2021_01_08_423993	476	1	Biol	Biol	NNP
10_1101-2021_01_08_423993	476	2	.	.	.
10_1101-2021_01_08_423993	477	1	22	22	CD
10_1101-2021_01_08_423993	477	2	,	,	,
10_1101-2021_01_08_423993	477	3	17–29	17–29	CD
10_1101-2021_01_08_423993	477	4	.	.	.
10_1101-2021_01_08_423993	478	1	23	23	CD
10_1101-2021_01_08_423993	478	2	.	.	.
10_1101-2021_01_08_423993	479	1	Pannunzio	Pannunzio	NNP
10_1101-2021_01_08_423993	479	2	NR	NR	NNP
10_1101-2021_01_08_423993	479	3	,	,	,
10_1101-2021_01_08_423993	479	4	Watanabe	Watanabe	NNP
10_1101-2021_01_08_423993	479	5	G	G	NNP
10_1101-2021_01_08_423993	479	6	&	&	CC
10_1101-2021_01_08_423993	479	7	Lieber	Lieber	NNP
10_1101-2021_01_08_423993	479	8	MR	MR	NNP
10_1101-2021_01_08_423993	479	9	(	(	-LRB-
10_1101-2021_01_08_423993	479	10	2018	2018	CD
10_1101-2021_01_08_423993	479	11	)	)	-RRB-
10_1101-2021_01_08_423993	479	12	Nonhomologous	nonhomologous	JJ
10_1101-2021_01_08_423993	479	13	DNA	dna	NN
10_1101-2021_01_08_423993	479	14	end	end	NN
10_1101-2021_01_08_423993	479	15	-	-	HYPH
10_1101-2021_01_08_423993	479	16	joining	join	VBG
10_1101-2021_01_08_423993	479	17	for	for	IN
10_1101-2021_01_08_423993	479	18	repair	repair	NN
10_1101-2021_01_08_423993	479	19	of	of	IN
10_1101-2021_01_08_423993	479	20	DNA	dna	NN
10_1101-2021_01_08_423993	479	21	double	double	JJ
10_1101-2021_01_08_423993	479	22	-	-	HYPH
10_1101-2021_01_08_423993	479	23	strand	strand	NN
10_1101-2021_01_08_423993	479	24	breaks	break	NNS
10_1101-2021_01_08_423993	479	25	.	.	.
10_1101-2021_01_08_423993	480	1	J.	J.	NNP
10_1101-2021_01_08_423993	480	2	Biol	Biol	NNP
10_1101-2021_01_08_423993	480	3	.	.	.
10_1101-2021_01_08_423993	481	1	Chem	Chem	NNP
10_1101-2021_01_08_423993	481	2	.	.	.
10_1101-2021_01_08_423993	482	1	293	293	CD
10_1101-2021_01_08_423993	482	2	,	,	,
10_1101-2021_01_08_423993	482	3	10512–10523	10512–10523	CD
10_1101-2021_01_08_423993	482	4	.	.	.
10_1101-2021_01_08_423993	483	1	24	24	CD
10_1101-2021_01_08_423993	483	2	.	.	.
10_1101-2021_01_08_423993	484	1	Shockett	Shockett	NNP
10_1101-2021_01_08_423993	484	2	PE	PE	NNP
10_1101-2021_01_08_423993	484	3	&	&	CC
10_1101-2021_01_08_423993	484	4	Schatz	Schatz	NNP
10_1101-2021_01_08_423993	484	5	DG	DG	NNP
10_1101-2021_01_08_423993	484	6	(	(	-LRB-
10_1101-2021_01_08_423993	484	7	1999	1999	CD
10_1101-2021_01_08_423993	484	8	)	)	-RRB-
10_1101-2021_01_08_423993	484	9	DNA	DNA	NNP
10_1101-2021_01_08_423993	484	10	Hairpin	Hairpin	NNP
10_1101-2021_01_08_423993	484	11	Opening	Opening	NNP
10_1101-2021_01_08_423993	484	12	Mediated	mediate	VBN
10_1101-2021_01_08_423993	484	13	by	by	IN
10_1101-2021_01_08_423993	484	14	the	the	DT
10_1101-2021_01_08_423993	484	15	RAG1	RAG1	NNP
10_1101-2021_01_08_423993	484	16	and	and	CC
10_1101-2021_01_08_423993	484	17	RAG2	RAG2	NNP
10_1101-2021_01_08_423993	484	18	.CC	.CC	NFP
10_1101-2021_01_08_423993	484	19	-	-	:
10_1101-2021_01_08_423993	484	20	BY	by	IN
10_1101-2021_01_08_423993	484	21	4.0	4.0	CD
10_1101-2021_01_08_423993	484	22	International	international	JJ
10_1101-2021_01_08_423993	484	23	licensemade	licensemade	NN
10_1101-2021_01_08_423993	484	24	available	available	JJ
10_1101-2021_01_08_423993	484	25	under	under	IN
10_1101-2021_01_08_423993	484	26	a	a	DT
10_1101-2021_01_08_423993	484	27	(	(	-LRB-
10_1101-2021_01_08_423993	484	28	which	which	WDT
10_1101-2021_01_08_423993	484	29	was	be	VBD
10_1101-2021_01_08_423993	484	30	not	not	RB
10_1101-2021_01_08_423993	484	31	certified	certify	VBN
10_1101-2021_01_08_423993	484	32	by	by	IN
10_1101-2021_01_08_423993	484	33	peer	peer	NN
10_1101-2021_01_08_423993	484	34	review	review	NN
10_1101-2021_01_08_423993	484	35	)	)	-RRB-
10_1101-2021_01_08_423993	484	36	is	be	VBZ
10_1101-2021_01_08_423993	484	37	the	the	DT
10_1101-2021_01_08_423993	484	38	author	author	NN
10_1101-2021_01_08_423993	484	39	/	/	SYM
10_1101-2021_01_08_423993	484	40	funder	funder	NN
10_1101-2021_01_08_423993	484	41	,	,	,
10_1101-2021_01_08_423993	484	42	who	who	WP
10_1101-2021_01_08_423993	484	43	has	have	VBZ
10_1101-2021_01_08_423993	484	44	granted	grant	VBN
10_1101-2021_01_08_423993	484	45	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	484	46	a	a	DT
10_1101-2021_01_08_423993	484	47	license	license	NN
10_1101-2021_01_08_423993	484	48	to	to	TO
10_1101-2021_01_08_423993	484	49	display	display	VB
10_1101-2021_01_08_423993	484	50	the	the	DT
10_1101-2021_01_08_423993	484	51	preprint	preprint	NN
10_1101-2021_01_08_423993	484	52	in	in	IN
10_1101-2021_01_08_423993	484	53	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	484	54	.	.	.
10_1101-2021_01_08_423993	485	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	485	2	is	be	VBZ
10_1101-2021_01_08_423993	485	3	The	the	DT
10_1101-2021_01_08_423993	485	4	copyright	copyright	NN
10_1101-2021_01_08_423993	485	5	holder	holder	NN
10_1101-2021_01_08_423993	485	6	for	for	IN
10_1101-2021_01_08_423993	485	7	this	this	DT
10_1101-2021_01_08_423993	485	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	485	9	version	version	NN
10_1101-2021_01_08_423993	485	10	posted	post	VBD
10_1101-2021_01_08_423993	485	11	January	January	NNP
10_1101-2021_01_08_423993	485	12	8	8	CD
10_1101-2021_01_08_423993	485	13	,	,	,
10_1101-2021_01_08_423993	485	14	2021	2021	CD
10_1101-2021_01_08_423993	485	15	.	.	.
10_1101-2021_01_08_423993	485	16	;	;	:
10_1101-2021_01_08_423993	485	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	485	18	:	:	:
10_1101-2021_01_08_423993	485	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	485	20	preprint	preprint	NN
10_1101-2021_01_08_423993	485	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	485	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2021_01_08_423993	485	23	Proteins	Proteins	NNP
10_1101-2021_01_08_423993	485	24	.	.	.
10_1101-2021_01_08_423993	486	1	Mol	Mol	NNP
10_1101-2021_01_08_423993	486	2	.	.	.
10_1101-2021_01_08_423993	487	1	Cell	cell	NN
10_1101-2021_01_08_423993	487	2	.	.	.
10_1101-2021_01_08_423993	488	1	Biol	Biol	NNP
10_1101-2021_01_08_423993	488	2	.	.	.
10_1101-2021_01_08_423993	489	1	19	19	CD
10_1101-2021_01_08_423993	489	2	,	,	,
10_1101-2021_01_08_423993	489	3	4159–4166	4159–4166	CD
10_1101-2021_01_08_423993	489	4	.	.	.
10_1101-2021_01_08_423993	490	1	25	25	CD
10_1101-2021_01_08_423993	490	2	.	.	.
10_1101-2021_01_08_423993	491	1	De	De	NNP
10_1101-2021_01_08_423993	491	2	P	P	NNP
10_1101-2021_01_08_423993	491	3	,	,	,
10_1101-2021_01_08_423993	491	4	Peak	Peak	NNP
10_1101-2021_01_08_423993	491	5	MM	MM	NNP
10_1101-2021_01_08_423993	491	6	&	&	CC
10_1101-2021_01_08_423993	491	7	Rodgers	Rodgers	NNP
10_1101-2021_01_08_423993	491	8	KK	KK	NNP
10_1101-2021_01_08_423993	491	9	(	(	-LRB-
10_1101-2021_01_08_423993	491	10	2004	2004	CD
10_1101-2021_01_08_423993	491	11	)	)	-RRB-
10_1101-2021_01_08_423993	491	12	DNA	dna	NN
10_1101-2021_01_08_423993	491	13	Cleavage	Cleavage	NNP
10_1101-2021_01_08_423993	491	14	Activity	Activity	NNP
10_1101-2021_01_08_423993	491	15	of	of	IN
10_1101-2021_01_08_423993	491	16	the	the	DT
10_1101-2021_01_08_423993	491	17	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	491	18	Recombination	Recombination	NNP
10_1101-2021_01_08_423993	491	19	Protein	Protein	NNP
10_1101-2021_01_08_423993	491	20	RAG1	RAG1	NNP
10_1101-2021_01_08_423993	491	21	Is	be	VBZ
10_1101-2021_01_08_423993	491	22	Autoregulated	autoregulate	VBN
10_1101-2021_01_08_423993	491	23	.	.	.
10_1101-2021_01_08_423993	492	1	Mol	Mol	NNP
10_1101-2021_01_08_423993	492	2	.	.	.
10_1101-2021_01_08_423993	493	1	Cell	cell	NN
10_1101-2021_01_08_423993	493	2	.	.	.
10_1101-2021_01_08_423993	494	1	Biol	Biol	NNP
10_1101-2021_01_08_423993	494	2	.	.	.
10_1101-2021_01_08_423993	495	1	24	24	CD
10_1101-2021_01_08_423993	495	2	,	,	,
10_1101-2021_01_08_423993	495	3	6850–6860	6850–6860	CD
10_1101-2021_01_08_423993	495	4	.	.	.
10_1101-2021_01_08_423993	496	1	26	26	CD
10_1101-2021_01_08_423993	496	2	.	.	.
10_1101-2021_01_08_423993	497	1	Kim	Kim	NNP
10_1101-2021_01_08_423993	497	2	MS	MS	NNP
10_1101-2021_01_08_423993	497	3	,	,	,
10_1101-2021_01_08_423993	497	4	Lapkouski	Lapkouski	NNP
10_1101-2021_01_08_423993	497	5	M	M	NNP
10_1101-2021_01_08_423993	497	6	,	,	,
10_1101-2021_01_08_423993	497	7	Yang	Yang	NNP
10_1101-2021_01_08_423993	497	8	W	W	NNP
10_1101-2021_01_08_423993	497	9	&	&	CC
10_1101-2021_01_08_423993	497	10	Gellert	Gellert	NNP
10_1101-2021_01_08_423993	497	11	M	M	NNP
10_1101-2021_01_08_423993	497	12	(	(	-LRB-
10_1101-2021_01_08_423993	497	13	2015	2015	CD
10_1101-2021_01_08_423993	497	14	)	)	-RRB-
10_1101-2021_01_08_423993	497	15	Crystal	crystal	NN
10_1101-2021_01_08_423993	497	16	structure	structure	NN
10_1101-2021_01_08_423993	497	17	of	of	IN
10_1101-2021_01_08_423993	497	18	the	the	DT
10_1101-2021_01_08_423993	497	19	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	497	20	recombinase	recombinase	NN
10_1101-2021_01_08_423993	497	21	RAG1-RAG2	RAG1-RAG2	NNP
10_1101-2021_01_08_423993	497	22	.	.	.
10_1101-2021_01_08_423993	498	1	Nature	nature	NN
10_1101-2021_01_08_423993	498	2	518	518	CD
10_1101-2021_01_08_423993	498	3	,	,	,
10_1101-2021_01_08_423993	498	4	507–511	507–511	CD
10_1101-2021_01_08_423993	498	5	.	.	.
10_1101-2021_01_08_423993	499	1	27	27	CD
10_1101-2021_01_08_423993	499	2	.	.	.
10_1101-2021_01_08_423993	500	1	Pannicke	Pannicke	NNP
10_1101-2021_01_08_423993	500	2	U	U	NNP
10_1101-2021_01_08_423993	500	3	,	,	,
10_1101-2021_01_08_423993	500	4	Ma	Ma	NNP
10_1101-2021_01_08_423993	500	5	Y	Y	NNP
10_1101-2021_01_08_423993	500	6	,	,	,
10_1101-2021_01_08_423993	500	7	Hopfner	Hopfner	NNP
10_1101-2021_01_08_423993	500	8	KP	KP	NNP
10_1101-2021_01_08_423993	500	9	,	,	,
10_1101-2021_01_08_423993	500	10	Niewolik	Niewolik	NNP
10_1101-2021_01_08_423993	500	11	D	D	NNP
10_1101-2021_01_08_423993	500	12	,	,	,
10_1101-2021_01_08_423993	500	13	Lieber	Lieber	NNP
10_1101-2021_01_08_423993	500	14	MR	MR	NNP
10_1101-2021_01_08_423993	500	15	&	&	CC
10_1101-2021_01_08_423993	500	16	Schwarz	Schwarz	NNP
10_1101-2021_01_08_423993	500	17	K	K	NNP
10_1101-2021_01_08_423993	500	18	(	(	-LRB-
10_1101-2021_01_08_423993	500	19	2004	2004	CD
10_1101-2021_01_08_423993	500	20	)	)	-RRB-
10_1101-2021_01_08_423993	500	21	Functional	functional	JJ
10_1101-2021_01_08_423993	500	22	and	and	CC
10_1101-2021_01_08_423993	500	23	biochemical	biochemical	JJ
10_1101-2021_01_08_423993	500	24	dissection	dissection	NN
10_1101-2021_01_08_423993	500	25	of	of	IN
10_1101-2021_01_08_423993	500	26	the	the	DT
10_1101-2021_01_08_423993	500	27	structure	structure	NN
10_1101-2021_01_08_423993	500	28	-	-	HYPH
10_1101-2021_01_08_423993	500	29	specific	specific	JJ
10_1101-2021_01_08_423993	500	30	nuclease	nuclease	NN
10_1101-2021_01_08_423993	500	31	ARTEMIS	artemi	NNS
10_1101-2021_01_08_423993	500	32	.	.	.
10_1101-2021_01_08_423993	501	1	EMBO	EMBO	NNP
10_1101-2021_01_08_423993	501	2	J.	J.	NNP
10_1101-2021_01_08_423993	502	1	23	23	CD
10_1101-2021_01_08_423993	502	2	,	,	,
10_1101-2021_01_08_423993	502	3	1987	1987	CD
10_1101-2021_01_08_423993	502	4	–	–	:
10_1101-2021_01_08_423993	502	5	1997	1997	CD
10_1101-2021_01_08_423993	502	6	.	.	.
10_1101-2021_01_08_423993	503	1	28	28	CD
10_1101-2021_01_08_423993	503	2	.	.	.
10_1101-2021_01_08_423993	504	1	Barnes	barne	NNS
10_1101-2021_01_08_423993	504	2	DE	DE	NNP
10_1101-2021_01_08_423993	504	3	,	,	,
10_1101-2021_01_08_423993	504	4	Stamp	Stamp	NNP
10_1101-2021_01_08_423993	504	5	G	G	NNP
10_1101-2021_01_08_423993	504	6	,	,	,
10_1101-2021_01_08_423993	504	7	Rosewell	Rosewell	NNP
10_1101-2021_01_08_423993	504	8	I	I	NNP
10_1101-2021_01_08_423993	504	9	,	,	,
10_1101-2021_01_08_423993	504	10	Denzel	Denzel	NNP
10_1101-2021_01_08_423993	504	11	A	A	NNP
10_1101-2021_01_08_423993	504	12	&	&	CC
10_1101-2021_01_08_423993	504	13	Lindahl	Lindahl	NNP
10_1101-2021_01_08_423993	504	14	T	T	NNP
10_1101-2021_01_08_423993	504	15	(	(	-LRB-
10_1101-2021_01_08_423993	504	16	1998	1998	CD
10_1101-2021_01_08_423993	504	17	)	)	-RRB-
10_1101-2021_01_08_423993	504	18	Targeted	target	VBN
10_1101-2021_01_08_423993	504	19	disruption	disruption	NN
10_1101-2021_01_08_423993	504	20	of	of	IN
10_1101-2021_01_08_423993	504	21	the	the	DT
10_1101-2021_01_08_423993	504	22	gene	gene	NN
10_1101-2021_01_08_423993	504	23	encoding	encode	VBG
10_1101-2021_01_08_423993	504	24	DNA	DNA	NNP
10_1101-2021_01_08_423993	504	25	ligase	ligase	NN
10_1101-2021_01_08_423993	504	26	IV	IV	NNP
10_1101-2021_01_08_423993	504	27	leads	lead	VBZ
10_1101-2021_01_08_423993	504	28	to	to	IN
10_1101-2021_01_08_423993	504	29	lethality	lethality	NN
10_1101-2021_01_08_423993	504	30	in	in	IN
10_1101-2021_01_08_423993	504	31	embryonic	embryonic	JJ
10_1101-2021_01_08_423993	504	32	mice	mouse	NNS
10_1101-2021_01_08_423993	504	33	.	.	.
10_1101-2021_01_08_423993	505	1	Curr	curr	UH
10_1101-2021_01_08_423993	505	2	.	.	.
10_1101-2021_01_08_423993	506	1	Biol	Biol	NNP
10_1101-2021_01_08_423993	506	2	.	.	.
10_1101-2021_01_08_423993	507	1	8	8	CD
10_1101-2021_01_08_423993	507	2	,	,	,
10_1101-2021_01_08_423993	507	3	1395	1395	CD
10_1101-2021_01_08_423993	507	4	–	–	:
10_1101-2021_01_08_423993	507	5	1398	1398	CD
10_1101-2021_01_08_423993	507	6	.	.	.
10_1101-2021_01_08_423993	508	1	29	29	CD
10_1101-2021_01_08_423993	508	2	.	.	.
10_1101-2021_01_08_423993	509	1	Roth	Roth	NNP
10_1101-2021_01_08_423993	509	2	DB	DB	NNP
10_1101-2021_01_08_423993	509	3	,	,	,
10_1101-2021_01_08_423993	509	4	Menetski	Menetski	NNP
10_1101-2021_01_08_423993	509	5	JP	JP	NNP
10_1101-2021_01_08_423993	509	6	,	,	,
10_1101-2021_01_08_423993	509	7	Nakajima	Nakajima	NNP
10_1101-2021_01_08_423993	509	8	P	P	NNP
10_1101-2021_01_08_423993	509	9	,	,	,
10_1101-2021_01_08_423993	509	10	Bosma	Bosma	NNP
10_1101-2021_01_08_423993	509	11	MJ	MJ	NNP
10_1101-2021_01_08_423993	509	12	&	&	CC
10_1101-2021_01_08_423993	509	13	Gellert	Gellert	NNP
10_1101-2021_01_08_423993	509	14	M	M	NNP
10_1101-2021_01_08_423993	509	15	(	(	-LRB-
10_1101-2021_01_08_423993	509	16	1992	1992	CD
10_1101-2021_01_08_423993	509	17	)	)	-RRB-
10_1101-2021_01_08_423993	509	18	V	v	NN
10_1101-2021_01_08_423993	509	19	(	(	-LRB-
10_1101-2021_01_08_423993	509	20	D	D	NNP
10_1101-2021_01_08_423993	509	21	)	)	-RRB-
10_1101-2021_01_08_423993	509	22	J	J	NNP
10_1101-2021_01_08_423993	509	23	Recombination	Recombination	NNP
10_1101-2021_01_08_423993	509	24	 	 	_SP
10_1101-2021_01_08_423993	509	25	:	:	:
10_1101-2021_01_08_423993	509	26	Broken	Broken	NNP
10_1101-2021_01_08_423993	509	27	DNA	dna	NN
10_1101-2021_01_08_423993	509	28	Molecules	molecule	NNS
10_1101-2021_01_08_423993	509	29	with	with	IN
10_1101-2021_01_08_423993	509	30	Covalently	Covalently	NNP
10_1101-2021_01_08_423993	509	31	Sealed	seal	VBN
10_1101-2021_01_08_423993	509	32	(	(	-LRB-
10_1101-2021_01_08_423993	509	33	Hairpin	Hairpin	NNP
10_1101-2021_01_08_423993	509	34	)	)	-RRB-
10_1101-2021_01_08_423993	509	35	Coding	Coding	NNP
10_1101-2021_01_08_423993	509	36	Ends	Ends	NNPS
10_1101-2021_01_08_423993	509	37	in	in	IN
10_1101-2021_01_08_423993	509	38	scid	scid	JJ
10_1101-2021_01_08_423993	509	39	Mouse	Mouse	NNP
10_1101-2021_01_08_423993	509	40	Thymocytes	Thymocytes	NNP
10_1101-2021_01_08_423993	509	41	.	.	.
10_1101-2021_01_08_423993	510	1	70	70	CD
10_1101-2021_01_08_423993	510	2	,	,	,
10_1101-2021_01_08_423993	510	3	983–991	983–991	CD
10_1101-2021_01_08_423993	510	4	.	.	.
10_1101-2021_01_08_423993	511	1	30	30	CD
10_1101-2021_01_08_423993	511	2	.	.	.
10_1101-2021_01_08_423993	512	1	Bassing	Bassing	NNP
10_1101-2021_01_08_423993	512	2	CH	CH	NNP
10_1101-2021_01_08_423993	512	3	,	,	,
10_1101-2021_01_08_423993	512	4	Swat	Swat	NNP
10_1101-2021_01_08_423993	512	5	W	W	NNP
10_1101-2021_01_08_423993	512	6	&	&	CC
10_1101-2021_01_08_423993	512	7	Alt	Alt	NNP
10_1101-2021_01_08_423993	512	8	FW	FW	NNP
10_1101-2021_01_08_423993	512	9	(	(	-LRB-
10_1101-2021_01_08_423993	512	10	2002	2002	CD
10_1101-2021_01_08_423993	512	11	)	)	-RRB-
10_1101-2021_01_08_423993	512	12	The	the	DT
10_1101-2021_01_08_423993	512	13	mechanism	mechanism	NN
10_1101-2021_01_08_423993	512	14	and	and	CC
10_1101-2021_01_08_423993	512	15	regulation	regulation	NN
10_1101-2021_01_08_423993	512	16	of	of	IN
10_1101-2021_01_08_423993	512	17	chromosomal	chromosomal	JJ
10_1101-2021_01_08_423993	512	18	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	512	19	recombination	recombination	NN
10_1101-2021_01_08_423993	512	20	.	.	.
10_1101-2021_01_08_423993	513	1	Cell	cell	NN
10_1101-2021_01_08_423993	513	2	109	109	CD
10_1101-2021_01_08_423993	513	3	,	,	,
10_1101-2021_01_08_423993	513	4	45–55	45–55	CD
10_1101-2021_01_08_423993	513	5	.	.	.
10_1101-2021_01_08_423993	514	1	31	31	CD
10_1101-2021_01_08_423993	514	2	.	.	.
10_1101-2021_01_08_423993	515	1	Ege	Ege	NNP
10_1101-2021_01_08_423993	515	2	M	M	NNP
10_1101-2021_01_08_423993	515	3	,	,	,
10_1101-2021_01_08_423993	515	4	Ma	Ma	NNP
10_1101-2021_01_08_423993	515	5	Y	Y	NNP
10_1101-2021_01_08_423993	515	6	,	,	,
10_1101-2021_01_08_423993	515	7	Manfras	Manfras	NNP
10_1101-2021_01_08_423993	515	8	B	B	NNP
10_1101-2021_01_08_423993	515	9	,	,	,
10_1101-2021_01_08_423993	515	10	Kalwak	Kalwak	NNP
10_1101-2021_01_08_423993	515	11	K	K	NNP
10_1101-2021_01_08_423993	515	12	,	,	,
10_1101-2021_01_08_423993	515	13	Lu	Lu	NNP
10_1101-2021_01_08_423993	515	14	H	H	NNP
10_1101-2021_01_08_423993	515	15	,	,	,
10_1101-2021_01_08_423993	515	16	Lieber	Lieber	NNP
10_1101-2021_01_08_423993	515	17	MR	MR	NNP
10_1101-2021_01_08_423993	515	18	,	,	,
10_1101-2021_01_08_423993	515	19	Schwarz	Schwarz	NNP
10_1101-2021_01_08_423993	515	20	K	K	NNP
10_1101-2021_01_08_423993	515	21	&	&	CC
10_1101-2021_01_08_423993	515	22	Pannicke	Pannicke	NNP
10_1101-2021_01_08_423993	515	23	U	U	NNP
10_1101-2021_01_08_423993	515	24	(	(	-LRB-
10_1101-2021_01_08_423993	515	25	2005	2005	CD
10_1101-2021_01_08_423993	515	26	)	)	-RRB-
10_1101-2021_01_08_423993	515	27	Plenary	plenary	JJ
10_1101-2021_01_08_423993	515	28	paper	paper	NN
10_1101-2021_01_08_423993	515	29	Omenn	Omenn	NNP
10_1101-2021_01_08_423993	515	30	syndrome	syndrome	NN
10_1101-2021_01_08_423993	515	31	due	due	JJ
10_1101-2021_01_08_423993	515	32	to	to	IN
10_1101-2021_01_08_423993	515	33	ARTEMIS	ARTEMIS	NNP
10_1101-2021_01_08_423993	515	34	mutations	mutation	NNS
10_1101-2021_01_08_423993	515	35	.	.	.
10_1101-2021_01_08_423993	516	1	Blood	blood	NN
10_1101-2021_01_08_423993	516	2	105	105	CD
10_1101-2021_01_08_423993	516	3	,	,	,
10_1101-2021_01_08_423993	516	4	4179–4186	4179–4186	CD
10_1101-2021_01_08_423993	516	5	.	.	.
10_1101-2021_01_08_423993	517	1	32	32	CD
10_1101-2021_01_08_423993	517	2	.	.	.
10_1101-2021_01_08_423993	518	1	Volk	Volk	NNP
10_1101-2021_01_08_423993	518	2	T	T	NNP
10_1101-2021_01_08_423993	518	3	,	,	,
10_1101-2021_01_08_423993	518	4	Pannicke	Pannicke	NNP
10_1101-2021_01_08_423993	518	5	U	U	NNP
10_1101-2021_01_08_423993	518	6	,	,	,
10_1101-2021_01_08_423993	518	7	Reisli	Reisli	NNP
10_1101-2021_01_08_423993	518	8	I	I	NNP
10_1101-2021_01_08_423993	518	9	,	,	,
10_1101-2021_01_08_423993	518	10	Bulashevska	Bulashevska	NNP
10_1101-2021_01_08_423993	518	11	A	A	NNP
10_1101-2021_01_08_423993	518	12	,	,	,
10_1101-2021_01_08_423993	518	13	Ritter	Ritter	NNP
10_1101-2021_01_08_423993	518	14	J	J	NNP
10_1101-2021_01_08_423993	518	15	,	,	,
10_1101-2021_01_08_423993	518	16	Björkman	Björkman	NNP
10_1101-2021_01_08_423993	518	17	A	A	NNP
10_1101-2021_01_08_423993	518	18	,	,	,
10_1101-2021_01_08_423993	518	19	Schäffer	Schäffer	NNP
10_1101-2021_01_08_423993	518	20	AA	AA	NNP
10_1101-2021_01_08_423993	518	21	,	,	,
10_1101-2021_01_08_423993	518	22	Fliegauf	Fliegauf	NNP
10_1101-2021_01_08_423993	518	23	M	M	NNP
10_1101-2021_01_08_423993	518	24	,	,	,
10_1101-2021_01_08_423993	518	25	Sayar	Sayar	NNP
10_1101-2021_01_08_423993	518	26	EH	EH	NNP
10_1101-2021_01_08_423993	518	27	,	,	,
10_1101-2021_01_08_423993	518	28	Salzer	Salzer	NNP
10_1101-2021_01_08_423993	518	29	U	U	NNP
10_1101-2021_01_08_423993	518	30	,	,	,
10_1101-2021_01_08_423993	518	31	Fisch	Fisch	NNP
10_1101-2021_01_08_423993	518	32	P	P	NNP
10_1101-2021_01_08_423993	518	33	,	,	,
10_1101-2021_01_08_423993	518	34	Pfeifer	Pfeifer	NNP
10_1101-2021_01_08_423993	518	35	D	D	NNP
10_1101-2021_01_08_423993	518	36	,	,	,
10_1101-2021_01_08_423993	518	37	Virgilio	Virgilio	NNP
10_1101-2021_01_08_423993	518	38	M	M	NNP
10_1101-2021_01_08_423993	518	39	Di	Di	NNP
10_1101-2021_01_08_423993	518	40	,	,	,
10_1101-2021_01_08_423993	518	41	Cao	Cao	NNP
10_1101-2021_01_08_423993	518	42	H	H	NNP
10_1101-2021_01_08_423993	518	43	,	,	,
10_1101-2021_01_08_423993	518	44	Yang	Yang	NNP
10_1101-2021_01_08_423993	518	45	F	F	NNP
10_1101-2021_01_08_423993	518	46	,	,	,
10_1101-2021_01_08_423993	518	47	Zimmermann	Zimmermann	NNP
10_1101-2021_01_08_423993	518	48	K	K	NNP
10_1101-2021_01_08_423993	518	49	,	,	,
10_1101-2021_01_08_423993	518	50	Keles	Keles	NNP
10_1101-2021_01_08_423993	518	51	S	S	NNP
10_1101-2021_01_08_423993	518	52	,	,	,
10_1101-2021_01_08_423993	518	53	Schindler	Schindler	NNP
10_1101-2021_01_08_423993	518	54	D	D	NNP
10_1101-2021_01_08_423993	518	55	,	,	,
10_1101-2021_01_08_423993	518	56	Hammarström	Hammarström	NNP
10_1101-2021_01_08_423993	518	57	L	L	NNP
10_1101-2021_01_08_423993	518	58	,	,	,
10_1101-2021_01_08_423993	518	59	Caliskaner	Caliskaner	NNP
10_1101-2021_01_08_423993	518	60	Z	Z	NNP
10_1101-2021_01_08_423993	518	61	,	,	,
10_1101-2021_01_08_423993	518	62	Rizzi	Rizzi	NNP
10_1101-2021_01_08_423993	518	63	M	M	NNP
10_1101-2021_01_08_423993	518	64	,	,	,
10_1101-2021_01_08_423993	518	65	Hummel	Hummel	NNP
10_1101-2021_01_08_423993	518	66	M	M	NNP
10_1101-2021_01_08_423993	518	67	,	,	,
10_1101-2021_01_08_423993	518	68	Pan	Pan	NNP
10_1101-2021_01_08_423993	518	69	-	-	HYPH
10_1101-2021_01_08_423993	518	70	hammarström	hammarström	NNP
10_1101-2021_01_08_423993	518	71	Q	Q	NNP
10_1101-2021_01_08_423993	518	72	,	,	,
10_1101-2021_01_08_423993	518	73	Schwarz	Schwarz	NNP
10_1101-2021_01_08_423993	518	74	K	K	NNP
10_1101-2021_01_08_423993	518	75	&	&	CC
10_1101-2021_01_08_423993	518	76	Grimbacher	Grimbacher	NNP
10_1101-2021_01_08_423993	518	77	B	B	NNP
10_1101-2021_01_08_423993	518	78	(	(	-LRB-
10_1101-2021_01_08_423993	518	79	2015	2015	CD
10_1101-2021_01_08_423993	518	80	)	)	-RRB-
10_1101-2021_01_08_423993	518	81	DCLRE1C	dclre1c	UH
10_1101-2021_01_08_423993	518	82	(	(	-LRB-
10_1101-2021_01_08_423993	518	83	ARTEMIS	ARTEMIS	NNP
10_1101-2021_01_08_423993	518	84	)	)	-RRB-
10_1101-2021_01_08_423993	518	85	mutations	mutation	NNS
10_1101-2021_01_08_423993	518	86	causing	cause	VBG
10_1101-2021_01_08_423993	518	87	phenotypes	phenotype	NNS
10_1101-2021_01_08_423993	518	88	ranging	range	VBG
10_1101-2021_01_08_423993	518	89	from	from	IN
10_1101-2021_01_08_423993	518	90	atypical	atypical	JJ
10_1101-2021_01_08_423993	518	91	severe	severe	JJ
10_1101-2021_01_08_423993	518	92	combined	combine	VBN
10_1101-2021_01_08_423993	518	93	immunodeficiency	immunodeficiency	NN
10_1101-2021_01_08_423993	518	94	to	to	IN
10_1101-2021_01_08_423993	518	95	mere	mere	JJ
10_1101-2021_01_08_423993	518	96	antibody	antibody	NN
10_1101-2021_01_08_423993	518	97	deficiency	deficiency	NN
10_1101-2021_01_08_423993	518	98	.	.	.
10_1101-2021_01_08_423993	519	1	24	24	CD
10_1101-2021_01_08_423993	519	2	,	,	,
10_1101-2021_01_08_423993	519	3	7361–7372	7361–7372	CD
10_1101-2021_01_08_423993	519	4	.	.	.
10_1101-2021_01_08_423993	520	1	33	33	CD
10_1101-2021_01_08_423993	520	2	.	.	.
10_1101-2021_01_08_423993	521	1	Li	Li	NNP
10_1101-2021_01_08_423993	521	2	L	L	NNP
10_1101-2021_01_08_423993	521	3	,	,	,
10_1101-2021_01_08_423993	521	4	Moshous	Moshous	NNP
10_1101-2021_01_08_423993	521	5	D	D	NNP
10_1101-2021_01_08_423993	521	6	,	,	,
10_1101-2021_01_08_423993	521	7	Zhou	Zhou	NNP
10_1101-2021_01_08_423993	521	8	Y	Y	NNP
10_1101-2021_01_08_423993	521	9	,	,	,
10_1101-2021_01_08_423993	521	10	Wang	Wang	NNP
10_1101-2021_01_08_423993	521	11	J	J	NNP
10_1101-2021_01_08_423993	521	12	,	,	,
10_1101-2021_01_08_423993	521	13	Xie	Xie	NNP
10_1101-2021_01_08_423993	521	14	G	G	NNP
10_1101-2021_01_08_423993	521	15	,	,	,
10_1101-2021_01_08_423993	521	16	Salido	Salido	NNP
10_1101-2021_01_08_423993	521	17	E	E	NNP
10_1101-2021_01_08_423993	521	18	,	,	,
10_1101-2021_01_08_423993	521	19	Hu	Hu	NNP
10_1101-2021_01_08_423993	521	20	D	D	NNP
10_1101-2021_01_08_423993	521	21	&	&	CC
10_1101-2021_01_08_423993	521	22	Cowan	Cowan	NNP
10_1101-2021_01_08_423993	521	23	MJ	MJ	NNP
10_1101-2021_01_08_423993	521	24	(	(	-LRB-
10_1101-2021_01_08_423993	521	25	2002	2002	CD
10_1101-2021_01_08_423993	521	26	)	)	-RRB-
10_1101-2021_01_08_423993	521	27	A	a	DT
10_1101-2021_01_08_423993	521	28	Founder	Founder	NNP
10_1101-2021_01_08_423993	521	29	Mutation	Mutation	NNP
10_1101-2021_01_08_423993	521	30	in	in	IN
10_1101-2021_01_08_423993	521	31	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	521	32	,	,	,
10_1101-2021_01_08_423993	521	33	an	an	DT
10_1101-2021_01_08_423993	521	34	SNM1-Like	SNM1-Like	NNP
10_1101-2021_01_08_423993	521	35	Protein	protein	NN
10_1101-2021_01_08_423993	521	36	,	,	,
10_1101-2021_01_08_423993	521	37	Causes	cause	VBZ
10_1101-2021_01_08_423993	521	38	SCID	scid	NN
10_1101-2021_01_08_423993	521	39	in	in	IN
10_1101-2021_01_08_423993	521	40	Athabascan	Athabascan	NNP
10_1101-2021_01_08_423993	521	41	-	-	HYPH
10_1101-2021_01_08_423993	521	42	Speaking	speak	VBG
10_1101-2021_01_08_423993	521	43	Native	Native	NNP
10_1101-2021_01_08_423993	521	44	Americans	Americans	NNPS
10_1101-2021_01_08_423993	521	45	.	.	.
10_1101-2021_01_08_423993	522	1	J.	J.	NNP
10_1101-2021_01_08_423993	522	2	Immunol	Immunol	NNP
10_1101-2021_01_08_423993	522	3	.	.	.
10_1101-2021_01_08_423993	523	1	168	168	CD
10_1101-2021_01_08_423993	523	2	,	,	,
10_1101-2021_01_08_423993	523	3	6323–6329	6323–6329	CD
10_1101-2021_01_08_423993	523	4	.	.	.
10_1101-2021_01_08_423993	524	1	34	34	CD
10_1101-2021_01_08_423993	524	2	.	.	.
10_1101-2021_01_08_423993	525	1	Felgentreff	Felgentreff	NNP
10_1101-2021_01_08_423993	525	2	K	K	NNP
10_1101-2021_01_08_423993	525	3	,	,	,
10_1101-2021_01_08_423993	525	4	Lee	Lee	NNP
10_1101-2021_01_08_423993	525	5	YN	YN	NNP
10_1101-2021_01_08_423993	525	6	,	,	,
10_1101-2021_01_08_423993	525	7	Frugoni	Frugoni	NNP
10_1101-2021_01_08_423993	525	8	F	F	NNP
10_1101-2021_01_08_423993	525	9	,	,	,
10_1101-2021_01_08_423993	525	10	Du	Du	NNP
10_1101-2021_01_08_423993	525	11	L	L	NNP
10_1101-2021_01_08_423993	525	12	,	,	,
10_1101-2021_01_08_423993	525	13	Van	Van	NNP
10_1101-2021_01_08_423993	525	14	Der	Der	NNP
10_1101-2021_01_08_423993	525	15	Burg	Burg	NNP
10_1101-2021_01_08_423993	525	16	M	M	NNP
10_1101-2021_01_08_423993	525	17	,	,	,
10_1101-2021_01_08_423993	525	18	Giliani	Giliani	NNP
10_1101-2021_01_08_423993	525	19	S	S	NNP
10_1101-2021_01_08_423993	525	20	,	,	,
10_1101-2021_01_08_423993	525	21	Tezcan	Tezcan	NNP
10_1101-2021_01_08_423993	525	22	I	-PRON-	PRP
10_1101-2021_01_08_423993	525	23	,	,	,
10_1101-2021_01_08_423993	525	24	Reisli	Reisli	NNP
10_1101-2021_01_08_423993	525	25	I	I	NNP
10_1101-2021_01_08_423993	525	26	,	,	,
10_1101-2021_01_08_423993	525	27	Mejstrikova	Mejstrikova	NNP
10_1101-2021_01_08_423993	525	28	E	E	NNP
10_1101-2021_01_08_423993	525	29	,	,	,
10_1101-2021_01_08_423993	525	30	De	De	NNP
10_1101-2021_01_08_423993	525	31	Villartay	Villartay	NNP
10_1101-2021_01_08_423993	525	32	JP	JP	NNP
10_1101-2021_01_08_423993	525	33	,	,	,
10_1101-2021_01_08_423993	525	34	Sleckman	Sleckman	NNP
10_1101-2021_01_08_423993	525	35	BP	BP	NNP
10_1101-2021_01_08_423993	525	36	,	,	,
10_1101-2021_01_08_423993	525	37	Manis	Manis	NNP
10_1101-2021_01_08_423993	525	38	J	J	NNP
10_1101-2021_01_08_423993	525	39	&	&	CC
10_1101-2021_01_08_423993	525	40	Notarangelo	Notarangelo	NNP
10_1101-2021_01_08_423993	525	41	LD	LD	NNP
10_1101-2021_01_08_423993	525	42	(	(	-LRB-
10_1101-2021_01_08_423993	525	43	2015	2015	CD
10_1101-2021_01_08_423993	525	44	)	)	-RRB-
10_1101-2021_01_08_423993	525	45	Functional	functional	JJ
10_1101-2021_01_08_423993	525	46	analysis	analysis	NN
10_1101-2021_01_08_423993	525	47	of	of	IN
10_1101-2021_01_08_423993	525	48	naturally	naturally	RB
10_1101-2021_01_08_423993	525	49	occurring	occur	VBG
10_1101-2021_01_08_423993	525	50	DCLRE1C	DCLRE1C	NNP
10_1101-2021_01_08_423993	525	51	mutations	mutation	NNS
10_1101-2021_01_08_423993	525	52	and	and	CC
10_1101-2021_01_08_423993	525	53	correlation	correlation	NN
10_1101-2021_01_08_423993	525	54	with	with	IN
10_1101-2021_01_08_423993	525	55	the	the	DT
10_1101-2021_01_08_423993	525	56	clinical	clinical	JJ
10_1101-2021_01_08_423993	525	57	phenotype	phenotype	NN
10_1101-2021_01_08_423993	525	58	of	of	IN
10_1101-2021_01_08_423993	525	59	ARTEMIS	ARTEMIS	NNP
10_1101-2021_01_08_423993	525	60	deficiency	deficiency	NN
10_1101-2021_01_08_423993	525	61	.	.	.
10_1101-2021_01_08_423993	526	1	J.	J.	NNP
10_1101-2021_01_08_423993	527	1	Allergy	Allergy	NNP
10_1101-2021_01_08_423993	527	2	Clin	Clin	NNP
10_1101-2021_01_08_423993	527	3	.	.	.
10_1101-2021_01_08_423993	528	1	Immunol	immunol	NN
10_1101-2021_01_08_423993	528	2	.	.	.
10_1101-2021_01_08_423993	529	1	136	136	CD
10_1101-2021_01_08_423993	529	2	,	,	,
10_1101-2021_01_08_423993	529	3	140	140	CD
10_1101-2021_01_08_423993	529	4	-	-	SYM
10_1101-2021_01_08_423993	529	5	150.e7	150.e7	CD
10_1101-2021_01_08_423993	529	6	.	.	.
10_1101-2021_01_08_423993	530	1	35	35	CD
10_1101-2021_01_08_423993	530	2	.	.	.
10_1101-2021_01_08_423993	531	1	Savitsky	Savitsky	NNP
10_1101-2021_01_08_423993	531	2	P	P	NNP
10_1101-2021_01_08_423993	531	3	,	,	,
10_1101-2021_01_08_423993	531	4	Bray	Bray	NNP
10_1101-2021_01_08_423993	531	5	J	J	NNP
10_1101-2021_01_08_423993	531	6	,	,	,
10_1101-2021_01_08_423993	531	7	Cooper	Cooper	NNP
10_1101-2021_01_08_423993	531	8	CDO	CDO	NNP
10_1101-2021_01_08_423993	531	9	,	,	,
10_1101-2021_01_08_423993	531	10	Marsden	Marsden	NNP
10_1101-2021_01_08_423993	531	11	BD	BD	NNP
10_1101-2021_01_08_423993	531	12	,	,	,
10_1101-2021_01_08_423993	531	13	Mahajan	Mahajan	NNP
10_1101-2021_01_08_423993	531	14	P	P	NNP
10_1101-2021_01_08_423993	531	15	,	,	,
10_1101-2021_01_08_423993	531	16	Burgess	Burgess	NNP
10_1101-2021_01_08_423993	531	17	-	-	HYPH
10_1101-2021_01_08_423993	531	18	Brown	Brown	NNP
10_1101-2021_01_08_423993	531	19	NA	NA	NNP
10_1101-2021_01_08_423993	531	20	&	&	CC
10_1101-2021_01_08_423993	531	21	Gileadi	Gileadi	NNP
10_1101-2021_01_08_423993	531	22	O	O	NNP
10_1101-2021_01_08_423993	531	23	(	(	-LRB-
10_1101-2021_01_08_423993	531	24	2010	2010	CD
10_1101-2021_01_08_423993	531	25	)	)	-RRB-
10_1101-2021_01_08_423993	531	26	High	high	JJ
10_1101-2021_01_08_423993	531	27	-	-	HYPH
10_1101-2021_01_08_423993	531	28	throughput	throughput	NN
10_1101-2021_01_08_423993	531	29	production	production	NN
10_1101-2021_01_08_423993	531	30	of	of	IN
10_1101-2021_01_08_423993	531	31	human	human	JJ
10_1101-2021_01_08_423993	531	32	proteins	protein	NNS
10_1101-2021_01_08_423993	531	33	for	for	IN
10_1101-2021_01_08_423993	531	34	crystallization	crystallization	NN
10_1101-2021_01_08_423993	531	35	:	:	:
10_1101-2021_01_08_423993	531	36	The	the	DT
10_1101-2021_01_08_423993	531	37	SGC	SGC	NNP
10_1101-2021_01_08_423993	531	38	experience	experience	NN
10_1101-2021_01_08_423993	531	39	.	.	.
10_1101-2021_01_08_423993	532	1	J.	J.	NNP
10_1101-2021_01_08_423993	532	2	Struct	Struct	NNP
10_1101-2021_01_08_423993	532	3	.	.	.
10_1101-2021_01_08_423993	533	1	Biol	Biol	NNP
10_1101-2021_01_08_423993	533	2	.	.	.
10_1101-2021_01_08_423993	534	1	172	172	CD
10_1101-2021_01_08_423993	534	2	,	,	,
10_1101-2021_01_08_423993	534	3	3–13	3–13	CD
10_1101-2021_01_08_423993	534	4	.	.	.
10_1101-2021_01_08_423993	535	1	36	36	CD
10_1101-2021_01_08_423993	535	2	.	.	.
10_1101-2021_01_08_423993	536	1	Dominy	Dominy	NNP
10_1101-2021_01_08_423993	536	2	CN	CN	NNP
10_1101-2021_01_08_423993	536	3	&	&	CC
10_1101-2021_01_08_423993	536	4	Andrews	Andrews	NNP
10_1101-2021_01_08_423993	536	5	DW	DW	NNP
10_1101-2021_01_08_423993	536	6	(	(	-LRB-
10_1101-2021_01_08_423993	536	7	2003	2003	CD
10_1101-2021_01_08_423993	536	8	)	)	-RRB-
10_1101-2021_01_08_423993	536	9	Site	site	NN
10_1101-2021_01_08_423993	536	10	-	-	HYPH
10_1101-2021_01_08_423993	536	11	directed	direct	VBN
10_1101-2021_01_08_423993	536	12	mutagenesis	mutagenesis	NN
10_1101-2021_01_08_423993	536	13	by	by	IN
10_1101-2021_01_08_423993	536	14	inverse	inverse	NN
10_1101-2021_01_08_423993	536	15	PCR	PCR	NNP
10_1101-2021_01_08_423993	536	16	.	.	.
10_1101-2021_01_08_423993	537	1	Methods	Methods	NNPS
10_1101-2021_01_08_423993	537	2	Mol	Mol	NNP
10_1101-2021_01_08_423993	537	3	.	.	.
10_1101-2021_01_08_423993	538	1	Biol	Biol	NNP
10_1101-2021_01_08_423993	538	2	.	.	.
10_1101-2021_01_08_423993	539	1	235	235	CD
10_1101-2021_01_08_423993	539	2	,	,	,
10_1101-2021_01_08_423993	539	3	209–223	209–223	CD
10_1101-2021_01_08_423993	539	4	.	.	.
10_1101-2021_01_08_423993	540	1	37	37	CD
10_1101-2021_01_08_423993	540	2	.	.	.
10_1101-2021_01_08_423993	541	1	Winter	winter	NN
10_1101-2021_01_08_423993	541	2	G	G	NNP
10_1101-2021_01_08_423993	541	3	,	,	,
10_1101-2021_01_08_423993	541	4	Waterman	Waterman	NNP
10_1101-2021_01_08_423993	541	5	DG	DG	NNP
10_1101-2021_01_08_423993	541	6	,	,	,
10_1101-2021_01_08_423993	541	7	Parkhurst	Parkhurst	NNP
10_1101-2021_01_08_423993	541	8	JM	JM	NNP
10_1101-2021_01_08_423993	541	9	,	,	,
10_1101-2021_01_08_423993	541	10	Brewster	Brewster	NNP
10_1101-2021_01_08_423993	541	11	AS	AS	NNP
10_1101-2021_01_08_423993	541	12	,	,	,
10_1101-2021_01_08_423993	541	13	Gildea	Gildea	NNP
10_1101-2021_01_08_423993	541	14	RJ	RJ	NNP
10_1101-2021_01_08_423993	541	15	,	,	,
10_1101-2021_01_08_423993	541	16	Gerstel	Gerstel	NNP
10_1101-2021_01_08_423993	541	17	M	M	NNP
10_1101-2021_01_08_423993	541	18	,	,	,
10_1101-2021_01_08_423993	541	19	Fuentes-	Fuentes-	NNP
10_1101-2021_01_08_423993	541	20	Montero	Montero	NNP
10_1101-2021_01_08_423993	541	21	L	L	NNP
10_1101-2021_01_08_423993	541	22	,	,	,
10_1101-2021_01_08_423993	541	23	Vollmar	Vollmar	NNP
10_1101-2021_01_08_423993	541	24	M	M	NNP
10_1101-2021_01_08_423993	541	25	,	,	,
10_1101-2021_01_08_423993	541	26	Michels	Michels	NNP
10_1101-2021_01_08_423993	541	27	-	-	HYPH
10_1101-2021_01_08_423993	541	28	Clark	Clark	NNP
10_1101-2021_01_08_423993	541	29	T	T	NNP
10_1101-2021_01_08_423993	541	30	,	,	,
10_1101-2021_01_08_423993	541	31	Young	Young	NNP
10_1101-2021_01_08_423993	541	32	ID	ID	NNP
10_1101-2021_01_08_423993	541	33	,	,	,
10_1101-2021_01_08_423993	541	34	Sauter	Sauter	NNP
10_1101-2021_01_08_423993	541	35	NK	NK	NNP
10_1101-2021_01_08_423993	541	36	&	&	CC
10_1101-2021_01_08_423993	541	37	Evans	Evans	NNP
10_1101-2021_01_08_423993	541	38	G	G	NNP
10_1101-2021_01_08_423993	541	39	(	(	-LRB-
10_1101-2021_01_08_423993	541	40	2018	2018	CD
10_1101-2021_01_08_423993	541	41	)	)	-RRB-
10_1101-2021_01_08_423993	541	42	DIALS	dial	NNS
10_1101-2021_01_08_423993	541	43	:	:	:
10_1101-2021_01_08_423993	541	44	Implementation	implementation	NN
10_1101-2021_01_08_423993	541	45	and	and	CC
10_1101-2021_01_08_423993	541	46	evaluation	evaluation	NN
10_1101-2021_01_08_423993	541	47	of	of	IN
10_1101-2021_01_08_423993	541	48	a	a	DT
10_1101-2021_01_08_423993	541	49	new	new	JJ
10_1101-2021_01_08_423993	541	50	integration	integration	NN
10_1101-2021_01_08_423993	541	51	package	package	NN
10_1101-2021_01_08_423993	541	52	.	.	.
10_1101-2021_01_08_423993	542	1	Acta	Acta	NNP
10_1101-2021_01_08_423993	542	2	Crystallogr	Crystallogr	NNP
10_1101-2021_01_08_423993	542	3	.	.	.
10_1101-2021_01_08_423993	543	1	Sect	Sect	NNP
10_1101-2021_01_08_423993	543	2	.	.	.
10_1101-2021_01_08_423993	544	1	D	D	NNP
10_1101-2021_01_08_423993	544	2	Struct	Struct	NNP
10_1101-2021_01_08_423993	544	3	.	.	.
10_1101-2021_01_08_423993	545	1	Biol	Biol	NNP
10_1101-2021_01_08_423993	545	2	.	.	.
10_1101-2021_01_08_423993	546	1	74	74	CD
10_1101-2021_01_08_423993	546	2	,	,	,
10_1101-2021_01_08_423993	546	3	85–97	85–97	CD
10_1101-2021_01_08_423993	546	4	.	.	.
10_1101-2021_01_08_423993	547	1	38	38	CD
10_1101-2021_01_08_423993	547	2	.	.	.
10_1101-2021_01_08_423993	548	1	McCoy	McCoy	NNP
10_1101-2021_01_08_423993	548	2	AJ	AJ	NNP
10_1101-2021_01_08_423993	548	3	,	,	,
10_1101-2021_01_08_423993	548	4	Grosse	Grosse	NNP
10_1101-2021_01_08_423993	548	5	-	-	HYPH
10_1101-2021_01_08_423993	548	6	Kunstleve	Kunstleve	NNP
10_1101-2021_01_08_423993	548	7	RW	RW	NNP
10_1101-2021_01_08_423993	548	8	,	,	,
10_1101-2021_01_08_423993	548	9	Adams	Adams	NNP
10_1101-2021_01_08_423993	548	10	PD	PD	NNP
10_1101-2021_01_08_423993	548	11	,	,	,
10_1101-2021_01_08_423993	548	12	Winn	Winn	NNP
10_1101-2021_01_08_423993	548	13	MD	MD	NNP
10_1101-2021_01_08_423993	548	14	,	,	,
10_1101-2021_01_08_423993	548	15	Storoni	Storoni	NNP
10_1101-2021_01_08_423993	548	16	LC	LC	NNP
10_1101-2021_01_08_423993	548	17	&	&	CC
10_1101-2021_01_08_423993	548	18	Read	read	VB
10_1101-2021_01_08_423993	548	19	RJ	RJ	NNP
10_1101-2021_01_08_423993	548	20	(	(	-LRB-
10_1101-2021_01_08_423993	548	21	2007	2007	CD
10_1101-2021_01_08_423993	548	22	)	)	-RRB-
10_1101-2021_01_08_423993	548	23	.CC	.CC	:
10_1101-2021_01_08_423993	548	24	-	-	:
10_1101-2021_01_08_423993	548	25	BY	by	IN
10_1101-2021_01_08_423993	548	26	4.0	4.0	CD
10_1101-2021_01_08_423993	548	27	International	international	JJ
10_1101-2021_01_08_423993	548	28	licensemade	licensemade	NN
10_1101-2021_01_08_423993	548	29	available	available	JJ
10_1101-2021_01_08_423993	548	30	under	under	IN
10_1101-2021_01_08_423993	548	31	a	a	DT
10_1101-2021_01_08_423993	548	32	(	(	-LRB-
10_1101-2021_01_08_423993	548	33	which	which	WDT
10_1101-2021_01_08_423993	548	34	was	be	VBD
10_1101-2021_01_08_423993	548	35	not	not	RB
10_1101-2021_01_08_423993	548	36	certified	certify	VBN
10_1101-2021_01_08_423993	548	37	by	by	IN
10_1101-2021_01_08_423993	548	38	peer	peer	NN
10_1101-2021_01_08_423993	548	39	review	review	NN
10_1101-2021_01_08_423993	548	40	)	)	-RRB-
10_1101-2021_01_08_423993	548	41	is	be	VBZ
10_1101-2021_01_08_423993	548	42	the	the	DT
10_1101-2021_01_08_423993	548	43	author	author	NN
10_1101-2021_01_08_423993	548	44	/	/	SYM
10_1101-2021_01_08_423993	548	45	funder	funder	NN
10_1101-2021_01_08_423993	548	46	,	,	,
10_1101-2021_01_08_423993	548	47	who	who	WP
10_1101-2021_01_08_423993	548	48	has	have	VBZ
10_1101-2021_01_08_423993	548	49	granted	grant	VBN
10_1101-2021_01_08_423993	548	50	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	548	51	a	a	DT
10_1101-2021_01_08_423993	548	52	license	license	NN
10_1101-2021_01_08_423993	548	53	to	to	TO
10_1101-2021_01_08_423993	548	54	display	display	VB
10_1101-2021_01_08_423993	548	55	the	the	DT
10_1101-2021_01_08_423993	548	56	preprint	preprint	NN
10_1101-2021_01_08_423993	548	57	in	in	IN
10_1101-2021_01_08_423993	548	58	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	548	59	.	.	.
10_1101-2021_01_08_423993	549	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	549	2	is	be	VBZ
10_1101-2021_01_08_423993	549	3	The	the	DT
10_1101-2021_01_08_423993	549	4	copyright	copyright	NN
10_1101-2021_01_08_423993	549	5	holder	holder	NN
10_1101-2021_01_08_423993	549	6	for	for	IN
10_1101-2021_01_08_423993	549	7	this	this	DT
10_1101-2021_01_08_423993	549	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	549	9	version	version	NN
10_1101-2021_01_08_423993	549	10	posted	post	VBD
10_1101-2021_01_08_423993	549	11	January	January	NNP
10_1101-2021_01_08_423993	549	12	8	8	CD
10_1101-2021_01_08_423993	549	13	,	,	,
10_1101-2021_01_08_423993	549	14	2021	2021	CD
10_1101-2021_01_08_423993	549	15	.	.	.
10_1101-2021_01_08_423993	549	16	;	;	:
10_1101-2021_01_08_423993	549	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	549	18	:	:	:
10_1101-2021_01_08_423993	549	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	549	20	preprint	preprint	NN
10_1101-2021_01_08_423993	549	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	CD
10_1101-2021_01_08_423993	549	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2021_01_08_423993	549	23	Phaser	Phaser	NNP
10_1101-2021_01_08_423993	549	24	crystallographic	crystallographic	JJ
10_1101-2021_01_08_423993	549	25	software	software	NN
10_1101-2021_01_08_423993	549	26	.	.	.
10_1101-2021_01_08_423993	550	1	J.	J.	NNP
10_1101-2021_01_08_423993	550	2	Appl	Appl	NNP
10_1101-2021_01_08_423993	550	3	.	.	.
10_1101-2021_01_08_423993	551	1	Crystallogr	Crystallogr	NNP
10_1101-2021_01_08_423993	551	2	.	.	.
10_1101-2021_01_08_423993	552	1	40	40	CD
10_1101-2021_01_08_423993	552	2	,	,	,
10_1101-2021_01_08_423993	552	3	658–674	658–674	CD
10_1101-2021_01_08_423993	552	4	.	.	.
10_1101-2021_01_08_423993	553	1	39	39	CD
10_1101-2021_01_08_423993	553	2	.	.	.
10_1101-2021_01_08_423993	554	1	Emsley	Emsley	NNP
10_1101-2021_01_08_423993	554	2	P	P	NNP
10_1101-2021_01_08_423993	554	3	&	&	CC
10_1101-2021_01_08_423993	554	4	Cowtan	Cowtan	NNP
10_1101-2021_01_08_423993	554	5	K	K	NNP
10_1101-2021_01_08_423993	554	6	(	(	-LRB-
10_1101-2021_01_08_423993	554	7	2004	2004	CD
10_1101-2021_01_08_423993	554	8	)	)	-RRB-
10_1101-2021_01_08_423993	554	9	Coot	Coot	NNP
10_1101-2021_01_08_423993	554	10	:	:	:
10_1101-2021_01_08_423993	554	11	Model	model	NN
10_1101-2021_01_08_423993	554	12	-	-	HYPH
10_1101-2021_01_08_423993	554	13	building	building	NN
10_1101-2021_01_08_423993	554	14	tools	tool	NNS
10_1101-2021_01_08_423993	554	15	for	for	IN
10_1101-2021_01_08_423993	554	16	molecular	molecular	JJ
10_1101-2021_01_08_423993	554	17	graphics	graphic	NNS
10_1101-2021_01_08_423993	554	18	.	.	.
10_1101-2021_01_08_423993	555	1	Acta	Acta	NNP
10_1101-2021_01_08_423993	555	2	Crystallogr	Crystallogr	NNP
10_1101-2021_01_08_423993	555	3	.	.	.
10_1101-2021_01_08_423993	556	1	Sect	Sect	NNP
10_1101-2021_01_08_423993	556	2	.	.	.
10_1101-2021_01_08_423993	557	1	D	D	NNP
10_1101-2021_01_08_423993	557	2	Biol	Biol	NNP
10_1101-2021_01_08_423993	557	3	.	.	.
10_1101-2021_01_08_423993	558	1	Crystallogr	Crystallogr	NNP
10_1101-2021_01_08_423993	558	2	.	.	.
10_1101-2021_01_08_423993	559	1	60	60	CD
10_1101-2021_01_08_423993	559	2	,	,	,
10_1101-2021_01_08_423993	559	3	2126–2132	2126–2132	CD
10_1101-2021_01_08_423993	559	4	.	.	.
10_1101-2021_01_08_423993	560	1	40	40	CD
10_1101-2021_01_08_423993	560	2	.	.	.
10_1101-2021_01_08_423993	561	1	Murshudov	murshudov	JJ
10_1101-2021_01_08_423993	561	2	GN	GN	NNP
10_1101-2021_01_08_423993	561	3	,	,	,
10_1101-2021_01_08_423993	561	4	Skubák	skubák	NN
10_1101-2021_01_08_423993	561	5	P	p	NN
10_1101-2021_01_08_423993	561	6	,	,	,
10_1101-2021_01_08_423993	561	7	Lebedev	Lebedev	NNP
10_1101-2021_01_08_423993	561	8	AA	AA	NNP
10_1101-2021_01_08_423993	561	9	,	,	,
10_1101-2021_01_08_423993	561	10	Pannu	Pannu	NNP
10_1101-2021_01_08_423993	561	11	NS	NS	NNP
10_1101-2021_01_08_423993	561	12	,	,	,
10_1101-2021_01_08_423993	561	13	Steiner	Steiner	NNP
10_1101-2021_01_08_423993	561	14	RA	RA	NNP
10_1101-2021_01_08_423993	561	15	,	,	,
10_1101-2021_01_08_423993	561	16	Nicholls	Nicholls	NNP
10_1101-2021_01_08_423993	561	17	RA	RA	NNP
10_1101-2021_01_08_423993	561	18	,	,	,
10_1101-2021_01_08_423993	561	19	Winn	Winn	NNP
10_1101-2021_01_08_423993	561	20	MD	MD	NNP
10_1101-2021_01_08_423993	561	21	,	,	,
10_1101-2021_01_08_423993	561	22	Long	Long	NNP
10_1101-2021_01_08_423993	561	23	F	F	NNP
10_1101-2021_01_08_423993	561	24	&	&	CC
10_1101-2021_01_08_423993	561	25	Vagin	Vagin	NNP
10_1101-2021_01_08_423993	561	26	AA	AA	NNP
10_1101-2021_01_08_423993	561	27	(	(	-LRB-
10_1101-2021_01_08_423993	561	28	2011	2011	CD
10_1101-2021_01_08_423993	561	29	)	)	-RRB-
10_1101-2021_01_08_423993	561	30	REFMAC5	REFMAC5	NNP
10_1101-2021_01_08_423993	561	31	for	for	IN
10_1101-2021_01_08_423993	561	32	the	the	DT
10_1101-2021_01_08_423993	561	33	refinement	refinement	NN
10_1101-2021_01_08_423993	561	34	of	of	IN
10_1101-2021_01_08_423993	561	35	macromolecular	macromolecular	JJ
10_1101-2021_01_08_423993	561	36	crystal	crystal	NN
10_1101-2021_01_08_423993	561	37	structures	structure	NNS
10_1101-2021_01_08_423993	561	38	.	.	.
10_1101-2021_01_08_423993	562	1	Acta	Acta	NNP
10_1101-2021_01_08_423993	562	2	Crystallogr	Crystallogr	NNP
10_1101-2021_01_08_423993	562	3	.	.	.
10_1101-2021_01_08_423993	563	1	Sect	Sect	NNP
10_1101-2021_01_08_423993	563	2	.	.	.
10_1101-2021_01_08_423993	564	1	D	D	NNP
10_1101-2021_01_08_423993	564	2	Biol	Biol	NNP
10_1101-2021_01_08_423993	564	3	.	.	.
10_1101-2021_01_08_423993	565	1	Crystallogr	Crystallogr	NNP
10_1101-2021_01_08_423993	565	2	.	.	.
10_1101-2021_01_08_423993	566	1	67	67	CD
10_1101-2021_01_08_423993	566	2	,	,	,
10_1101-2021_01_08_423993	566	3	355–367	355–367	CD
10_1101-2021_01_08_423993	566	4	.	.	.
10_1101-2021_01_08_423993	567	1	41	41	CD
10_1101-2021_01_08_423993	567	2	.	.	.
10_1101-2021_01_08_423993	568	1	Lee	Lee	NNP
10_1101-2021_01_08_423993	568	2	SY	SY	NNP
10_1101-2021_01_08_423993	568	3	,	,	,
10_1101-2021_01_08_423993	568	4	Brem	Brem	NNP
10_1101-2021_01_08_423993	568	5	J	J	NNP
10_1101-2021_01_08_423993	568	6	,	,	,
10_1101-2021_01_08_423993	568	7	Pettinati	Pettinati	NNP
10_1101-2021_01_08_423993	568	8	I	I	NNP
10_1101-2021_01_08_423993	568	9	,	,	,
10_1101-2021_01_08_423993	568	10	Claridge	Claridge	NNP
10_1101-2021_01_08_423993	568	11	TDW	TDW	NNP
10_1101-2021_01_08_423993	568	12	,	,	,
10_1101-2021_01_08_423993	568	13	Gileadi	Gileadi	NNP
10_1101-2021_01_08_423993	568	14	O	O	NNP
10_1101-2021_01_08_423993	568	15	,	,	,
10_1101-2021_01_08_423993	568	16	Schofield	Schofield	NNP
10_1101-2021_01_08_423993	568	17	CJ	CJ	NNP
10_1101-2021_01_08_423993	568	18	&	&	CC
10_1101-2021_01_08_423993	568	19	McHugh	McHugh	NNP
10_1101-2021_01_08_423993	568	20	PJ	PJ	NNP
10_1101-2021_01_08_423993	568	21	(	(	-LRB-
10_1101-2021_01_08_423993	568	22	2016	2016	CD
10_1101-2021_01_08_423993	568	23	)	)	-RRB-
10_1101-2021_01_08_423993	568	24	Cephalosporins	cephalosporin	NNS
10_1101-2021_01_08_423993	568	25	inhibit	inhibit	VBP
10_1101-2021_01_08_423993	568	26	human	human	JJ
10_1101-2021_01_08_423993	568	27	metallo	metallo	NN
10_1101-2021_01_08_423993	568	28	β	β	NN
10_1101-2021_01_08_423993	568	29	-	-	HYPH
10_1101-2021_01_08_423993	568	30	lactamase	lactamase	NNP
10_1101-2021_01_08_423993	568	31	fold	fold	VB
10_1101-2021_01_08_423993	568	32	DNA	dna	NN
10_1101-2021_01_08_423993	568	33	repair	repair	NN
10_1101-2021_01_08_423993	568	34	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	568	35	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	568	36	and	and	CC
10_1101-2021_01_08_423993	568	37	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	568	38	/	/	SYM
10_1101-2021_01_08_423993	568	39	apollo	apollo	NN
10_1101-2021_01_08_423993	568	40	.	.	.
10_1101-2021_01_08_423993	569	1	Chem	Chem	NNP
10_1101-2021_01_08_423993	569	2	.	.	.
10_1101-2021_01_08_423993	570	1	Commun	Commun	VBN
10_1101-2021_01_08_423993	570	2	.	.	.
10_1101-2021_01_08_423993	571	1	52	52	CD
10_1101-2021_01_08_423993	571	2	,	,	,
10_1101-2021_01_08_423993	571	3	6727–6730	6727–6730	CD
10_1101-2021_01_08_423993	571	4	.	.	.
10_1101-2021_01_08_423993	572	1	42	42	CD
10_1101-2021_01_08_423993	572	2	.	.	.
10_1101-2021_01_08_423993	573	1	Carfi	Carfi	NNP
10_1101-2021_01_08_423993	573	2	A	A	NNP
10_1101-2021_01_08_423993	573	3	,	,	,
10_1101-2021_01_08_423993	573	4	Pares	Pares	NNP
10_1101-2021_01_08_423993	573	5	S	S	NNP
10_1101-2021_01_08_423993	573	6	,	,	,
10_1101-2021_01_08_423993	573	7	Duée	Duée	NNP
10_1101-2021_01_08_423993	573	8	E	E	NNP
10_1101-2021_01_08_423993	573	9	,	,	,
10_1101-2021_01_08_423993	573	10	Galleni	Galleni	NNP
10_1101-2021_01_08_423993	573	11	M	M	NNP
10_1101-2021_01_08_423993	573	12	,	,	,
10_1101-2021_01_08_423993	573	13	Duez	Duez	NNP
10_1101-2021_01_08_423993	573	14	C	C	NNP
10_1101-2021_01_08_423993	573	15	,	,	,
10_1101-2021_01_08_423993	573	16	Frère	Frère	NNP
10_1101-2021_01_08_423993	573	17	JM	JM	NNP
10_1101-2021_01_08_423993	573	18	&	&	CC
10_1101-2021_01_08_423993	573	19	Dideberg	Dideberg	NNP
10_1101-2021_01_08_423993	573	20	O	O	NNP
10_1101-2021_01_08_423993	573	21	(	(	-LRB-
10_1101-2021_01_08_423993	573	22	1995	1995	CD
10_1101-2021_01_08_423993	573	23	)	)	-RRB-
10_1101-2021_01_08_423993	573	24	The	the	DT
10_1101-2021_01_08_423993	573	25	3-D	3-d	CD
10_1101-2021_01_08_423993	573	26	structure	structure	NN
10_1101-2021_01_08_423993	573	27	of	of	IN
10_1101-2021_01_08_423993	573	28	a	a	DT
10_1101-2021_01_08_423993	573	29	zinc	zinc	NN
10_1101-2021_01_08_423993	573	30	metallo	metallo	NN
10_1101-2021_01_08_423993	573	31	-	-	HYPH
10_1101-2021_01_08_423993	573	32	β	β	NN
10_1101-2021_01_08_423993	573	33	-	-	HYPH
10_1101-2021_01_08_423993	573	34	lactamase	lactamase	NN
10_1101-2021_01_08_423993	573	35	from	from	IN
10_1101-2021_01_08_423993	573	36	Bacillus	Bacillus	NNP
10_1101-2021_01_08_423993	573	37	cereus	cereus	NN
10_1101-2021_01_08_423993	573	38	reveals	reveal	VBZ
10_1101-2021_01_08_423993	573	39	a	a	DT
10_1101-2021_01_08_423993	573	40	new	new	JJ
10_1101-2021_01_08_423993	573	41	type	type	NN
10_1101-2021_01_08_423993	573	42	of	of	IN
10_1101-2021_01_08_423993	573	43	protein	protein	NN
10_1101-2021_01_08_423993	573	44	fold	fold	NN
10_1101-2021_01_08_423993	573	45	.	.	.
10_1101-2021_01_08_423993	574	1	EMBO	EMBO	NNP
10_1101-2021_01_08_423993	574	2	J.	J.	NNP
10_1101-2021_01_08_423993	575	1	14	14	CD
10_1101-2021_01_08_423993	575	2	,	,	,
10_1101-2021_01_08_423993	575	3	4914–4921	4914–4921	CD
10_1101-2021_01_08_423993	575	4	.	.	.
10_1101-2021_01_08_423993	576	1	43	43	CD
10_1101-2021_01_08_423993	576	2	.	.	.
10_1101-2021_01_08_423993	577	1	Li	Li	NNP
10_1101-2021_01_08_423993	577	2	X	X	NNP
10_1101-2021_01_08_423993	577	3	&	&	CC
10_1101-2021_01_08_423993	577	4	Moses	Moses	NNP
10_1101-2021_01_08_423993	577	5	RE	RE	NNP
10_1101-2021_01_08_423993	577	6	(	(	-LRB-
10_1101-2021_01_08_423993	577	7	2003	2003	CD
10_1101-2021_01_08_423993	577	8	)	)	-RRB-
10_1101-2021_01_08_423993	577	9	The	the	DT
10_1101-2021_01_08_423993	577	10	β	β	NN
10_1101-2021_01_08_423993	577	11	-	-	HYPH
10_1101-2021_01_08_423993	577	12	lactamase	lactamase	NN
10_1101-2021_01_08_423993	577	13	motif	motif	NN
10_1101-2021_01_08_423993	577	14	in	in	IN
10_1101-2021_01_08_423993	577	15	Snm1	Snm1	NNP
10_1101-2021_01_08_423993	577	16	is	be	VBZ
10_1101-2021_01_08_423993	577	17	required	require	VBN
10_1101-2021_01_08_423993	577	18	for	for	IN
10_1101-2021_01_08_423993	577	19	repair	repair	NN
10_1101-2021_01_08_423993	577	20	of	of	IN
10_1101-2021_01_08_423993	577	21	DNA	dna	NN
10_1101-2021_01_08_423993	577	22	double	double	JJ
10_1101-2021_01_08_423993	577	23	-	-	HYPH
10_1101-2021_01_08_423993	577	24	strand	strand	NN
10_1101-2021_01_08_423993	577	25	breaks	break	NNS
10_1101-2021_01_08_423993	577	26	caused	cause	VBN
10_1101-2021_01_08_423993	577	27	by	by	IN
10_1101-2021_01_08_423993	577	28	interstrand	interstrand	NNP
10_1101-2021_01_08_423993	577	29	crosslinks	crosslink	NNS
10_1101-2021_01_08_423993	577	30	in	in	IN
10_1101-2021_01_08_423993	577	31	S.	S.	NNP
10_1101-2021_01_08_423993	577	32	cerevisiae	cerevisiae	NNS
10_1101-2021_01_08_423993	577	33	.	.	.
10_1101-2021_01_08_423993	578	1	DNA	DNA	NNP
10_1101-2021_01_08_423993	578	2	Repair	Repair	NNP
10_1101-2021_01_08_423993	578	3	(	(	-LRB-
10_1101-2021_01_08_423993	578	4	Amst	Amst	NNP
10_1101-2021_01_08_423993	578	5	)	)	-RRB-
10_1101-2021_01_08_423993	578	6	.	.	.
10_1101-2021_01_08_423993	579	1	2	2	CD
10_1101-2021_01_08_423993	579	2	,	,	,
10_1101-2021_01_08_423993	579	3	121–129	121–129	CD
10_1101-2021_01_08_423993	579	4	.	.	.
10_1101-2021_01_08_423993	580	1	44	44	CD
10_1101-2021_01_08_423993	580	2	.	.	.
10_1101-2021_01_08_423993	580	3	de	de	NNP
10_1101-2021_01_08_423993	580	4	Villartay	Villartay	NNP
10_1101-2021_01_08_423993	580	5	JP	JP	NNP
10_1101-2021_01_08_423993	580	6	,	,	,
10_1101-2021_01_08_423993	580	7	Shimazaki	Shimazaki	NNP
10_1101-2021_01_08_423993	580	8	N	N	NNP
10_1101-2021_01_08_423993	580	9	,	,	,
10_1101-2021_01_08_423993	580	10	Charbonnier	Charbonnier	NNP
10_1101-2021_01_08_423993	580	11	JB	JB	NNP
10_1101-2021_01_08_423993	580	12	,	,	,
10_1101-2021_01_08_423993	580	13	Fischer	Fischer	NNP
10_1101-2021_01_08_423993	580	14	A	A	NNP
10_1101-2021_01_08_423993	580	15	,	,	,
10_1101-2021_01_08_423993	580	16	Mornon	Mornon	NNP
10_1101-2021_01_08_423993	580	17	JP	JP	NNP
10_1101-2021_01_08_423993	580	18	,	,	,
10_1101-2021_01_08_423993	580	19	Lieber	Lieber	NNP
10_1101-2021_01_08_423993	580	20	MR	MR	NNP
10_1101-2021_01_08_423993	580	21	&	&	CC
10_1101-2021_01_08_423993	580	22	Callebaut	Callebaut	NNP
10_1101-2021_01_08_423993	580	23	I	I	NNP
10_1101-2021_01_08_423993	580	24	(	(	-LRB-
10_1101-2021_01_08_423993	580	25	2009	2009	CD
10_1101-2021_01_08_423993	580	26	)	)	-RRB-
10_1101-2021_01_08_423993	580	27	A	a	DT
10_1101-2021_01_08_423993	580	28	histidine	histidine	NN
10_1101-2021_01_08_423993	580	29	in	in	IN
10_1101-2021_01_08_423993	580	30	the	the	DT
10_1101-2021_01_08_423993	580	31	β	β	NNP
10_1101-2021_01_08_423993	580	32	-	-	HYPH
10_1101-2021_01_08_423993	580	33	CASP	CASP	NNP
10_1101-2021_01_08_423993	580	34	domain	domain	NN
10_1101-2021_01_08_423993	580	35	of	of	IN
10_1101-2021_01_08_423993	580	36	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	580	37	is	be	VBZ
10_1101-2021_01_08_423993	580	38	critical	critical	JJ
10_1101-2021_01_08_423993	580	39	for	for	IN
10_1101-2021_01_08_423993	580	40	its	-PRON-	PRP$
10_1101-2021_01_08_423993	580	41	full	full	JJ
10_1101-2021_01_08_423993	580	42	in	in	FW
10_1101-2021_01_08_423993	580	43	vitro	vitro	FW
10_1101-2021_01_08_423993	580	44	and	and	CC
10_1101-2021_01_08_423993	580	45	in	in	IN
10_1101-2021_01_08_423993	580	46	vivo	vivo	NNP
10_1101-2021_01_08_423993	580	47	functions	function	NNS
10_1101-2021_01_08_423993	580	48	.	.	.
10_1101-2021_01_08_423993	581	1	DNA	DNA	NNP
10_1101-2021_01_08_423993	581	2	Repair	Repair	NNP
10_1101-2021_01_08_423993	581	3	(	(	-LRB-
10_1101-2021_01_08_423993	581	4	Amst	Amst	NNP
10_1101-2021_01_08_423993	581	5	)	)	-RRB-
10_1101-2021_01_08_423993	581	6	.	.	.
10_1101-2021_01_08_423993	582	1	8	8	CD
10_1101-2021_01_08_423993	582	2	,	,	,
10_1101-2021_01_08_423993	582	3	202–208	202–208	CD
10_1101-2021_01_08_423993	582	4	.	.	.
10_1101-2021_01_08_423993	583	1	45	45	CD
10_1101-2021_01_08_423993	583	2	.	.	.
10_1101-2021_01_08_423993	584	1	Mandel	Mandel	NNP
10_1101-2021_01_08_423993	584	2	CR	CR	NNP
10_1101-2021_01_08_423993	584	3	,	,	,
10_1101-2021_01_08_423993	584	4	Kaneko	Kaneko	NNP
10_1101-2021_01_08_423993	584	5	S	S	NNP
10_1101-2021_01_08_423993	584	6	,	,	,
10_1101-2021_01_08_423993	584	7	Zhang	Zhang	NNP
10_1101-2021_01_08_423993	584	8	H	H	NNP
10_1101-2021_01_08_423993	584	9	,	,	,
10_1101-2021_01_08_423993	584	10	Gebauer	Gebauer	NNP
10_1101-2021_01_08_423993	584	11	D	D	NNP
10_1101-2021_01_08_423993	584	12	,	,	,
10_1101-2021_01_08_423993	584	13	Vethantham	Vethantham	NNP
10_1101-2021_01_08_423993	584	14	V	V	NNP
10_1101-2021_01_08_423993	584	15	,	,	,
10_1101-2021_01_08_423993	584	16	Manley	Manley	NNP
10_1101-2021_01_08_423993	584	17	JL	JL	NNP
10_1101-2021_01_08_423993	584	18	&	&	CC
10_1101-2021_01_08_423993	584	19	Tong	Tong	NNP
10_1101-2021_01_08_423993	584	20	L	L	NNP
10_1101-2021_01_08_423993	584	21	(	(	-LRB-
10_1101-2021_01_08_423993	584	22	2006	2006	CD
10_1101-2021_01_08_423993	584	23	)	)	-RRB-
10_1101-2021_01_08_423993	584	24	Polyadenylation	polyadenylation	NN
10_1101-2021_01_08_423993	584	25	factor	factor	NN
10_1101-2021_01_08_423993	584	26	CPSF-73	CPSF-73	,
10_1101-2021_01_08_423993	584	27	is	be	VBZ
10_1101-2021_01_08_423993	584	28	the	the	DT
10_1101-2021_01_08_423993	584	29	pre	pre	JJ
10_1101-2021_01_08_423993	584	30	-	-	JJ
10_1101-2021_01_08_423993	584	31	mRNA	mrna	JJ
10_1101-2021_01_08_423993	584	32	3′-end	3′-end	NN
10_1101-2021_01_08_423993	584	33	-	-	HYPH
10_1101-2021_01_08_423993	584	34	processing	processing	NN
10_1101-2021_01_08_423993	584	35	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	584	36	.	.	.
10_1101-2021_01_08_423993	585	1	Nature	nature	NN
10_1101-2021_01_08_423993	585	2	444	444	CD
10_1101-2021_01_08_423993	585	3	,	,	,
10_1101-2021_01_08_423993	585	4	953–956	953–956	CD
10_1101-2021_01_08_423993	585	5	.	.	.
10_1101-2021_01_08_423993	586	1	46	46	CD
10_1101-2021_01_08_423993	586	2	.	.	.
10_1101-2021_01_08_423993	587	1	Alberts	Alberts	NNPS
10_1101-2021_01_08_423993	587	2	IL	IL	NNP
10_1101-2021_01_08_423993	587	3	,	,	,
10_1101-2021_01_08_423993	587	4	Nadassy	Nadassy	NNP
10_1101-2021_01_08_423993	587	5	K	K	NNP
10_1101-2021_01_08_423993	587	6	&	&	CC
10_1101-2021_01_08_423993	587	7	Wodak	Wodak	NNP
10_1101-2021_01_08_423993	587	8	SJ	SJ	NNP
10_1101-2021_01_08_423993	587	9	(	(	-LRB-
10_1101-2021_01_08_423993	587	10	1998	1998	CD
10_1101-2021_01_08_423993	587	11	)	)	-RRB-
10_1101-2021_01_08_423993	587	12	Analysis	Analysis	NNP
10_1101-2021_01_08_423993	587	13	of	of	IN
10_1101-2021_01_08_423993	587	14	zinc	zinc	NN
10_1101-2021_01_08_423993	587	15	binding	bind	VBG
10_1101-2021_01_08_423993	587	16	sites	site	NNS
10_1101-2021_01_08_423993	587	17	in	in	IN
10_1101-2021_01_08_423993	587	18	protein	protein	NN
10_1101-2021_01_08_423993	587	19	crystal	crystal	NN
10_1101-2021_01_08_423993	587	20	structures	structure	NNS
10_1101-2021_01_08_423993	587	21	.	.	.
10_1101-2021_01_08_423993	588	1	Protein	Protein	NNP
10_1101-2021_01_08_423993	588	2	Sci	Sci	NNP
10_1101-2021_01_08_423993	588	3	.	.	.
10_1101-2021_01_08_423993	589	1	7	7	CD
10_1101-2021_01_08_423993	589	2	,	,	,
10_1101-2021_01_08_423993	589	3	1700–1716	1700–1716	CD
10_1101-2021_01_08_423993	589	4	.	.	.
10_1101-2021_01_08_423993	590	1	47	47	CD
10_1101-2021_01_08_423993	590	2	.	.	.
10_1101-2021_01_08_423993	591	1	Ataie	Ataie	NNP
10_1101-2021_01_08_423993	591	2	NJ	NJ	NNP
10_1101-2021_01_08_423993	591	3	,	,	,
10_1101-2021_01_08_423993	591	4	Hoang	Hoang	NNP
10_1101-2021_01_08_423993	591	5	QQ	QQ	NNP
10_1101-2021_01_08_423993	591	6	,	,	,
10_1101-2021_01_08_423993	591	7	Zahniser	Zahniser	NNP
10_1101-2021_01_08_423993	591	8	MPD	MPD	NNP
10_1101-2021_01_08_423993	591	9	,	,	,
10_1101-2021_01_08_423993	591	10	Tu	Tu	NNP
10_1101-2021_01_08_423993	591	11	Y	Y	NNP
10_1101-2021_01_08_423993	591	12	,	,	,
10_1101-2021_01_08_423993	591	13	Milne	Milne	NNP
10_1101-2021_01_08_423993	591	14	A	A	NNP
10_1101-2021_01_08_423993	591	15	,	,	,
10_1101-2021_01_08_423993	591	16	Petsko	Petsko	NNP
10_1101-2021_01_08_423993	591	17	GA	GA	NNP
10_1101-2021_01_08_423993	591	18	&	&	CC
10_1101-2021_01_08_423993	591	19	Ringe	Ringe	NNP
10_1101-2021_01_08_423993	591	20	D	D	NNP
10_1101-2021_01_08_423993	591	21	(	(	-LRB-
10_1101-2021_01_08_423993	591	22	2008	2008	CD
10_1101-2021_01_08_423993	591	23	)	)	-RRB-
10_1101-2021_01_08_423993	591	24	Zinc	Zinc	NNP
10_1101-2021_01_08_423993	591	25	Coordination	Coordination	NNP
10_1101-2021_01_08_423993	591	26	Geometry	Geometry	NNP
10_1101-2021_01_08_423993	591	27	and	and	CC
10_1101-2021_01_08_423993	591	28	Ligand	Ligand	NNP
10_1101-2021_01_08_423993	591	29	Binding	Binding	NNP
10_1101-2021_01_08_423993	591	30	Affinity	affinity	NN
10_1101-2021_01_08_423993	591	31	:	:	:
10_1101-2021_01_08_423993	591	32	The	The	NNP
10_1101-2021_01_08_423993	591	33	Structural	Structural	NNP
10_1101-2021_01_08_423993	591	34	and	and	CC
10_1101-2021_01_08_423993	591	35	Kinetic	Kinetic	NNP
10_1101-2021_01_08_423993	591	36	Analysis	Analysis	NNP
10_1101-2021_01_08_423993	591	37	of	of	IN
10_1101-2021_01_08_423993	591	38	the	the	DT
10_1101-2021_01_08_423993	591	39	Second	Second	NNP
10_1101-2021_01_08_423993	591	40	-	-	HYPH
10_1101-2021_01_08_423993	591	41	Shell	Shell	NNP
10_1101-2021_01_08_423993	591	42	Serine	Serine	NNP
10_1101-2021_01_08_423993	591	43	228	228	CD
10_1101-2021_01_08_423993	591	44	Residue	Residue	NNP
10_1101-2021_01_08_423993	591	45	and	and	CC
10_1101-2021_01_08_423993	591	46	the	the	DT
10_1101-2021_01_08_423993	591	47	Methionine	Methionine	NNP
10_1101-2021_01_08_423993	591	48	180	180	CD
10_1101-2021_01_08_423993	591	49	Residue	residue	NN
10_1101-2021_01_08_423993	591	50	of	of	IN
10_1101-2021_01_08_423993	591	51	the	the	DT
10_1101-2021_01_08_423993	591	52	Aminopeptidase	Aminopeptidase	NNP
10_1101-2021_01_08_423993	591	53	from	from	IN
10_1101-2021_01_08_423993	591	54	Vibrio	Vibrio	NNP
10_1101-2021_01_08_423993	591	55	proteolyticus	proteolyticus	NN
10_1101-2021_01_08_423993	591	56	†.	†.	.
10_1101-2021_01_08_423993	592	1	Biochemistry	Biochemistry	NNP
10_1101-2021_01_08_423993	592	2	47	47	CD
10_1101-2021_01_08_423993	592	3	,	,	,
10_1101-2021_01_08_423993	592	4	7673–7683	7673–7683	CD
10_1101-2021_01_08_423993	592	5	.	.	.
10_1101-2021_01_08_423993	593	1	48	48	CD
10_1101-2021_01_08_423993	593	2	.	.	.
10_1101-2021_01_08_423993	594	1	Ishikawa	Ishikawa	NNP
10_1101-2021_01_08_423993	594	2	H	H	NNP
10_1101-2021_01_08_423993	594	3	,	,	,
10_1101-2021_01_08_423993	594	4	Nakagawa	Nakagawa	NNP
10_1101-2021_01_08_423993	594	5	N	N	NNP
10_1101-2021_01_08_423993	594	6	,	,	,
10_1101-2021_01_08_423993	594	7	Kuramitsu	Kuramitsu	NNP
10_1101-2021_01_08_423993	594	8	S	S	NNP
10_1101-2021_01_08_423993	594	9	&	&	CC
10_1101-2021_01_08_423993	594	10	Masui	Masui	NNP
10_1101-2021_01_08_423993	594	11	R	R	NNP
10_1101-2021_01_08_423993	594	12	(	(	-LRB-
10_1101-2021_01_08_423993	594	13	2006	2006	CD
10_1101-2021_01_08_423993	594	14	)	)	-RRB-
10_1101-2021_01_08_423993	594	15	Crystal	Crystal	NNP
10_1101-2021_01_08_423993	594	16	Structure	Structure	NNP
10_1101-2021_01_08_423993	594	17	of	of	IN
10_1101-2021_01_08_423993	594	18	TTHA0252	TTHA0252	NNP
10_1101-2021_01_08_423993	594	19	from	from	IN
10_1101-2021_01_08_423993	594	20	Thermus	Thermus	NNP
10_1101-2021_01_08_423993	594	21	thermophilus	thermophilus	NN
10_1101-2021_01_08_423993	594	22	HB8	HB8	NNP
10_1101-2021_01_08_423993	594	23	,	,	,
10_1101-2021_01_08_423993	594	24	a	a	DT
10_1101-2021_01_08_423993	594	25	RNA	RNA	NNP
10_1101-2021_01_08_423993	594	26	Degradation	Degradation	NNP
10_1101-2021_01_08_423993	594	27	Protein	Protein	NNP
10_1101-2021_01_08_423993	594	28	of	of	IN
10_1101-2021_01_08_423993	594	29	the	the	DT
10_1101-2021_01_08_423993	594	30	Metallo-	Metallo-	NNP
10_1101-2021_01_08_423993	594	31	b	b	NNP
10_1101-2021_01_08_423993	594	32	-	-	HYPH
10_1101-2021_01_08_423993	594	33	lactamase	lactamase	NN
10_1101-2021_01_08_423993	594	34	Superfamily	Superfamily	NNP
10_1101-2021_01_08_423993	594	35	.	.	.
10_1101-2021_01_08_423993	595	1	542	542	CD
10_1101-2021_01_08_423993	595	2	,	,	,
10_1101-2021_01_08_423993	595	3	535–542	535–542	CD
10_1101-2021_01_08_423993	595	4	.	.	.
10_1101-2021_01_08_423993	596	1	49	49	CD
10_1101-2021_01_08_423993	596	2	.	.	.
10_1101-2021_01_08_423993	597	1	Matthews	Matthews	NNP
10_1101-2021_01_08_423993	597	2	JM	JM	NNP
10_1101-2021_01_08_423993	597	3	&	&	CC
10_1101-2021_01_08_423993	597	4	Sunde	Sunde	NNP
10_1101-2021_01_08_423993	597	5	M	M	NNP
10_1101-2021_01_08_423993	597	6	(	(	-LRB-
10_1101-2021_01_08_423993	597	7	2002	2002	CD
10_1101-2021_01_08_423993	597	8	)	)	-RRB-
10_1101-2021_01_08_423993	597	9	Zinc	zinc	NN
10_1101-2021_01_08_423993	597	10	fingers	finger	NNS
10_1101-2021_01_08_423993	597	11	-	-	HYPH
10_1101-2021_01_08_423993	597	12	Folds	fold	NNS
10_1101-2021_01_08_423993	597	13	for	for	IN
10_1101-2021_01_08_423993	597	14	many	many	JJ
10_1101-2021_01_08_423993	597	15	occasions	occasion	NNS
10_1101-2021_01_08_423993	597	16	.	.	.
10_1101-2021_01_08_423993	598	1	IUBMB	IUBMB	NNP
10_1101-2021_01_08_423993	598	2	Life	Life	NNP
10_1101-2021_01_08_423993	598	3	54	54	CD
10_1101-2021_01_08_423993	598	4	,	,	,
10_1101-2021_01_08_423993	598	5	351–355	351–355	CD
10_1101-2021_01_08_423993	598	6	.	.	.
10_1101-2021_01_08_423993	599	1	50	50	CD
10_1101-2021_01_08_423993	599	2	.	.	.
10_1101-2021_01_08_423993	600	1	Wolfe	Wolfe	NNP
10_1101-2021_01_08_423993	600	2	SA	SA	NNP
10_1101-2021_01_08_423993	600	3	,	,	,
10_1101-2021_01_08_423993	600	4	Nekludova	Nekludova	NNP
10_1101-2021_01_08_423993	600	5	L	L	NNP
10_1101-2021_01_08_423993	600	6	&	&	CC
10_1101-2021_01_08_423993	600	7	Pabo	Pabo	NNP
10_1101-2021_01_08_423993	600	8	CO	CO	NNP
10_1101-2021_01_08_423993	600	9	(	(	-LRB-
10_1101-2021_01_08_423993	600	10	2000	2000	CD
10_1101-2021_01_08_423993	600	11	)	)	-RRB-
10_1101-2021_01_08_423993	600	12	DNA	dna	NN
10_1101-2021_01_08_423993	600	13	Recognition	Recognition	NNP
10_1101-2021_01_08_423993	600	14	by	by	IN
10_1101-2021_01_08_423993	600	15	Cys	Cys	NNP
10_1101-2021_01_08_423993	600	16	2	2	CD
10_1101-2021_01_08_423993	600	17	His	-PRON-	PRP$
10_1101-2021_01_08_423993	600	18	2	2	CD
10_1101-2021_01_08_423993	600	19	Zinc	Zinc	NNP
10_1101-2021_01_08_423993	600	20	Finger	Finger	NNP
10_1101-2021_01_08_423993	600	21	Proteins	Proteins	NNPS
10_1101-2021_01_08_423993	600	22	.	.	.
10_1101-2021_01_08_423993	601	1	Annu	Annu	NNP
10_1101-2021_01_08_423993	601	2	.	.	.
10_1101-2021_01_08_423993	602	1	Rev.	Rev.	NNP
10_1101-2021_01_08_423993	603	1	Biophys	Biophys	NNP
10_1101-2021_01_08_423993	603	2	.	.	.
10_1101-2021_01_08_423993	604	1	Biomol	Biomol	NNP
10_1101-2021_01_08_423993	604	2	.	.	.
10_1101-2021_01_08_423993	605	1	Struct	struct	NN
10_1101-2021_01_08_423993	605	2	.	.	.
10_1101-2021_01_08_423993	606	1	29	29	CD
10_1101-2021_01_08_423993	606	2	,	,	,
10_1101-2021_01_08_423993	606	3	183–212	183–212	CD
10_1101-2021_01_08_423993	606	4	.	.	.
10_1101-2021_01_08_423993	607	1	51	51	CD
10_1101-2021_01_08_423993	607	2	.	.	.
10_1101-2021_01_08_423993	608	1	Krishna	Krishna	NNP
10_1101-2021_01_08_423993	608	2	SS	SS	NNP
10_1101-2021_01_08_423993	608	3	,	,	,
10_1101-2021_01_08_423993	608	4	Majumdar	Majumdar	NNP
10_1101-2021_01_08_423993	608	5	I	-PRON-	PRP
10_1101-2021_01_08_423993	608	6	&	&	CC
10_1101-2021_01_08_423993	608	7	Grishin	Grishin	NNP
10_1101-2021_01_08_423993	608	8	N	N	NNP
10_1101-2021_01_08_423993	608	9	V.	V.	NNP
10_1101-2021_01_08_423993	608	10	(	(	-LRB-
10_1101-2021_01_08_423993	608	11	2003	2003	CD
10_1101-2021_01_08_423993	608	12	)	)	-RRB-
10_1101-2021_01_08_423993	608	13	Structural	structural	JJ
10_1101-2021_01_08_423993	608	14	classification	classification	NN
10_1101-2021_01_08_423993	608	15	of	of	IN
10_1101-2021_01_08_423993	608	16	zinc	zinc	NN
10_1101-2021_01_08_423993	608	17	fingers	finger	NNS
10_1101-2021_01_08_423993	608	18	.	.	.
10_1101-2021_01_08_423993	609	1	Nucleic	Nucleic	NNP
10_1101-2021_01_08_423993	609	2	Acids	Acids	NNPS
10_1101-2021_01_08_423993	609	3	Res	Res	NNP
10_1101-2021_01_08_423993	609	4	.	.	.
10_1101-2021_01_08_423993	610	1	31	31	CD
10_1101-2021_01_08_423993	610	2	,	,	,
10_1101-2021_01_08_423993	610	3	532–550	532–550	CD
10_1101-2021_01_08_423993	610	4	.	.	.
10_1101-2021_01_08_423993	611	1	52	52	CD
10_1101-2021_01_08_423993	611	2	.	.	.
10_1101-2021_01_08_423993	612	1	Singh	Singh	NNP
10_1101-2021_01_08_423993	612	2	JK	JK	NNP
10_1101-2021_01_08_423993	612	3	&	&	CC
10_1101-2021_01_08_423993	612	4	van	van	NNP
10_1101-2021_01_08_423993	612	5	Attikum	Attikum	NNP
10_1101-2021_01_08_423993	612	6	H	H	NNP
10_1101-2021_01_08_423993	612	7	(	(	-LRB-
10_1101-2021_01_08_423993	612	8	2020	2020	CD
10_1101-2021_01_08_423993	612	9	)	)	-RRB-
10_1101-2021_01_08_423993	612	10	DNA	dna	NN
10_1101-2021_01_08_423993	612	11	double	double	JJ
10_1101-2021_01_08_423993	612	12	-	-	HYPH
10_1101-2021_01_08_423993	612	13	strand	strand	NN
10_1101-2021_01_08_423993	612	14	break	break	NN
10_1101-2021_01_08_423993	612	15	repair	repair	NN
10_1101-2021_01_08_423993	612	16	:	:	:
10_1101-2021_01_08_423993	612	17	Putting	put	VBG
10_1101-2021_01_08_423993	612	18	zinc	zinc	NN
10_1101-2021_01_08_423993	612	19	fingers	finger	NNS
10_1101-2021_01_08_423993	612	20	on	on	IN
10_1101-2021_01_08_423993	612	21	the	the	DT
10_1101-2021_01_08_423993	612	22	sore	sore	JJ
10_1101-2021_01_08_423993	612	23	spot	spot	NN
10_1101-2021_01_08_423993	612	24	.	.	.
10_1101-2021_01_08_423993	613	1	Semin	Semin	NNP
10_1101-2021_01_08_423993	613	2	.	.	.
10_1101-2021_01_08_423993	614	1	Cell	Cell	NNP
10_1101-2021_01_08_423993	614	2	Dev	Dev	NNP
10_1101-2021_01_08_423993	614	3	.	.	.
10_1101-2021_01_08_423993	615	1	Biol	Biol	NNP
10_1101-2021_01_08_423993	615	2	.	.	.
10_1101-2021_01_08_423993	616	1	53	53	CD
10_1101-2021_01_08_423993	616	2	.	.	.
10_1101-2021_01_08_423993	617	1	Wu	Wu	NNP
10_1101-2021_01_08_423993	617	2	X	X	NNP
10_1101-2021_01_08_423993	617	3	,	,	,
10_1101-2021_01_08_423993	617	4	Bishopric	Bishopric	NNP
10_1101-2021_01_08_423993	617	5	NH	NH	NNP
10_1101-2021_01_08_423993	617	6	,	,	,
10_1101-2021_01_08_423993	617	7	Discher	Discher	NNP
10_1101-2021_01_08_423993	617	8	DJ	DJ	NNP
10_1101-2021_01_08_423993	617	9	,	,	,
10_1101-2021_01_08_423993	617	10	Murphy	Murphy	NNP
10_1101-2021_01_08_423993	617	11	BJ	BJ	NNP
10_1101-2021_01_08_423993	617	12	&	&	CC
10_1101-2021_01_08_423993	617	13	Webster	Webster	NNP
10_1101-2021_01_08_423993	617	14	KA	KA	NNP
10_1101-2021_01_08_423993	617	15	(	(	-LRB-
10_1101-2021_01_08_423993	617	16	1996	1996	CD
10_1101-2021_01_08_423993	617	17	)	)	-RRB-
10_1101-2021_01_08_423993	617	18	Physical	physical	JJ
10_1101-2021_01_08_423993	617	19	and	and	CC
10_1101-2021_01_08_423993	617	20	functional	functional	JJ
10_1101-2021_01_08_423993	617	21	sensitivity	sensitivity	NN
10_1101-2021_01_08_423993	617	22	of	of	IN
10_1101-2021_01_08_423993	617	23	zinc	zinc	NN
10_1101-2021_01_08_423993	617	24	finger	finger	NN
10_1101-2021_01_08_423993	617	25	transcription	transcription	NN
10_1101-2021_01_08_423993	617	26	factors	factor	NNS
10_1101-2021_01_08_423993	617	27	to	to	IN
10_1101-2021_01_08_423993	617	28	redox	redox	NN
10_1101-2021_01_08_423993	617	29	change	change	NN
10_1101-2021_01_08_423993	617	30	.	.	.
10_1101-2021_01_08_423993	618	1	Mol	Mol	NNP
10_1101-2021_01_08_423993	618	2	.	.	.
10_1101-2021_01_08_423993	619	1	Cell	cell	NN
10_1101-2021_01_08_423993	619	2	.	.	.
10_1101-2021_01_08_423993	620	1	Biol	Biol	NNP
10_1101-2021_01_08_423993	620	2	.	.	.
10_1101-2021_01_08_423993	621	1	16	16	CD
10_1101-2021_01_08_423993	621	2	,	,	,
10_1101-2021_01_08_423993	621	3	1035	1035	CD
10_1101-2021_01_08_423993	621	4	–	–	:
10_1101-2021_01_08_423993	621	5	1046	1046	CD
10_1101-2021_01_08_423993	621	6	.	.	.
10_1101-2021_01_08_423993	622	1	.CC	.CC	NFP
10_1101-2021_01_08_423993	622	2	-	-	:
10_1101-2021_01_08_423993	622	3	BY	by	IN
10_1101-2021_01_08_423993	622	4	4.0	4.0	CD
10_1101-2021_01_08_423993	622	5	International	international	JJ
10_1101-2021_01_08_423993	622	6	licensemade	licensemade	NN
10_1101-2021_01_08_423993	622	7	available	available	JJ
10_1101-2021_01_08_423993	622	8	under	under	IN
10_1101-2021_01_08_423993	622	9	a	a	DT
10_1101-2021_01_08_423993	622	10	(	(	-LRB-
10_1101-2021_01_08_423993	622	11	which	which	WDT
10_1101-2021_01_08_423993	622	12	was	be	VBD
10_1101-2021_01_08_423993	622	13	not	not	RB
10_1101-2021_01_08_423993	622	14	certified	certify	VBN
10_1101-2021_01_08_423993	622	15	by	by	IN
10_1101-2021_01_08_423993	622	16	peer	peer	NN
10_1101-2021_01_08_423993	622	17	review	review	NN
10_1101-2021_01_08_423993	622	18	)	)	-RRB-
10_1101-2021_01_08_423993	622	19	is	be	VBZ
10_1101-2021_01_08_423993	622	20	the	the	DT
10_1101-2021_01_08_423993	622	21	author	author	NN
10_1101-2021_01_08_423993	622	22	/	/	SYM
10_1101-2021_01_08_423993	622	23	funder	funder	NN
10_1101-2021_01_08_423993	622	24	,	,	,
10_1101-2021_01_08_423993	622	25	who	who	WP
10_1101-2021_01_08_423993	622	26	has	have	VBZ
10_1101-2021_01_08_423993	622	27	granted	grant	VBN
10_1101-2021_01_08_423993	622	28	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	622	29	a	a	DT
10_1101-2021_01_08_423993	622	30	license	license	NN
10_1101-2021_01_08_423993	622	31	to	to	TO
10_1101-2021_01_08_423993	622	32	display	display	VB
10_1101-2021_01_08_423993	622	33	the	the	DT
10_1101-2021_01_08_423993	622	34	preprint	preprint	NN
10_1101-2021_01_08_423993	622	35	in	in	IN
10_1101-2021_01_08_423993	622	36	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	622	37	.	.	.
10_1101-2021_01_08_423993	623	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	623	2	is	be	VBZ
10_1101-2021_01_08_423993	623	3	The	the	DT
10_1101-2021_01_08_423993	623	4	copyright	copyright	NN
10_1101-2021_01_08_423993	623	5	holder	holder	NN
10_1101-2021_01_08_423993	623	6	for	for	IN
10_1101-2021_01_08_423993	623	7	this	this	DT
10_1101-2021_01_08_423993	623	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	623	9	version	version	NN
10_1101-2021_01_08_423993	623	10	posted	post	VBD
10_1101-2021_01_08_423993	623	11	January	January	NNP
10_1101-2021_01_08_423993	623	12	8	8	CD
10_1101-2021_01_08_423993	623	13	,	,	,
10_1101-2021_01_08_423993	623	14	2021	2021	CD
10_1101-2021_01_08_423993	623	15	.	.	.
10_1101-2021_01_08_423993	623	16	;	;	:
10_1101-2021_01_08_423993	623	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	623	18	:	:	:
10_1101-2021_01_08_423993	623	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	623	20	preprint	preprint	NN
10_1101-2021_01_08_423993	623	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	NN
10_1101-2021_01_08_423993	623	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	623	23	54	54	CD
10_1101-2021_01_08_423993	623	24	.	.	.
10_1101-2021_01_08_423993	624	1	Laity	Laity	NNP
10_1101-2021_01_08_423993	624	2	JH	JH	NNP
10_1101-2021_01_08_423993	624	3	,	,	,
10_1101-2021_01_08_423993	624	4	Lee	Lee	NNP
10_1101-2021_01_08_423993	624	5	BM	BM	NNP
10_1101-2021_01_08_423993	624	6	&	&	CC
10_1101-2021_01_08_423993	624	7	Wright	Wright	NNP
10_1101-2021_01_08_423993	624	8	PE	PE	NNP
10_1101-2021_01_08_423993	624	9	(	(	-LRB-
10_1101-2021_01_08_423993	624	10	2001	2001	CD
10_1101-2021_01_08_423993	624	11	)	)	-RRB-
10_1101-2021_01_08_423993	624	12	Zinc	Zinc	NNP
10_1101-2021_01_08_423993	624	13	finger	finger	NN
10_1101-2021_01_08_423993	624	14	proteins	protein	VBZ
10_1101-2021_01_08_423993	624	15	:	:	:
10_1101-2021_01_08_423993	624	16	New	new	JJ
10_1101-2021_01_08_423993	624	17	insights	insight	NNS
10_1101-2021_01_08_423993	624	18	into	into	IN
10_1101-2021_01_08_423993	624	19	structural	structural	JJ
10_1101-2021_01_08_423993	624	20	and	and	CC
10_1101-2021_01_08_423993	624	21	functional	functional	JJ
10_1101-2021_01_08_423993	624	22	diversity	diversity	NN
10_1101-2021_01_08_423993	624	23	.	.	.
10_1101-2021_01_08_423993	625	1	Curr	curr	UH
10_1101-2021_01_08_423993	625	2	.	.	.
10_1101-2021_01_08_423993	626	1	Opin	opin	JJ
10_1101-2021_01_08_423993	626	2	.	.	.
10_1101-2021_01_08_423993	627	1	Struct	struct	NN
10_1101-2021_01_08_423993	627	2	.	.	.
10_1101-2021_01_08_423993	628	1	Biol	Biol	NNP
10_1101-2021_01_08_423993	628	2	.	.	.
10_1101-2021_01_08_423993	629	1	11	11	CD
10_1101-2021_01_08_423993	629	2	,	,	,
10_1101-2021_01_08_423993	629	3	39–46	39–46	CD
10_1101-2021_01_08_423993	629	4	.	.	.
10_1101-2021_01_08_423993	630	1	55	55	CD
10_1101-2021_01_08_423993	630	2	.	.	.
10_1101-2021_01_08_423993	631	1	Pannicke	Pannicke	NNP
10_1101-2021_01_08_423993	631	2	U	U	NNP
10_1101-2021_01_08_423993	631	3	,	,	,
10_1101-2021_01_08_423993	631	4	Hönig	Hönig	NNP
10_1101-2021_01_08_423993	631	5	M	M	NNP
10_1101-2021_01_08_423993	631	6	,	,	,
10_1101-2021_01_08_423993	631	7	Schulze	Schulze	NNP
10_1101-2021_01_08_423993	631	8	I	I	NNP
10_1101-2021_01_08_423993	631	9	,	,	,
10_1101-2021_01_08_423993	631	10	Rohr	Rohr	NNP
10_1101-2021_01_08_423993	631	11	J	J	NNP
10_1101-2021_01_08_423993	631	12	,	,	,
10_1101-2021_01_08_423993	631	13	Heinz	Heinz	NNP
10_1101-2021_01_08_423993	631	14	GA	GA	NNP
10_1101-2021_01_08_423993	631	15	,	,	,
10_1101-2021_01_08_423993	631	16	Braun	Braun	NNP
10_1101-2021_01_08_423993	631	17	S	S	NNP
10_1101-2021_01_08_423993	631	18	,	,	,
10_1101-2021_01_08_423993	631	19	Janz	Janz	NNP
10_1101-2021_01_08_423993	631	20	I	I	NNP
10_1101-2021_01_08_423993	631	21	,	,	,
10_1101-2021_01_08_423993	631	22	Rump	rump	VB
10_1101-2021_01_08_423993	631	23	EM	EM	NNP
10_1101-2021_01_08_423993	631	24	,	,	,
10_1101-2021_01_08_423993	631	25	Seidel	Seidel	NNP
10_1101-2021_01_08_423993	631	26	MG	MG	NNP
10_1101-2021_01_08_423993	631	27	,	,	,
10_1101-2021_01_08_423993	631	28	Matthes	Matthes	NNP
10_1101-2021_01_08_423993	631	29	-	-	HYPH
10_1101-2021_01_08_423993	631	30	Martin	Martin	NNP
10_1101-2021_01_08_423993	631	31	S	S	NNP
10_1101-2021_01_08_423993	631	32	,	,	,
10_1101-2021_01_08_423993	631	33	Soerensen	Soerensen	NNP
10_1101-2021_01_08_423993	631	34	J	J	NNP
10_1101-2021_01_08_423993	631	35	,	,	,
10_1101-2021_01_08_423993	631	36	Greil	Greil	NNP
10_1101-2021_01_08_423993	631	37	J	J	NNP
10_1101-2021_01_08_423993	631	38	,	,	,
10_1101-2021_01_08_423993	631	39	Stachel	Stachel	NNP
10_1101-2021_01_08_423993	631	40	DK	DK	NNP
10_1101-2021_01_08_423993	631	41	,	,	,
10_1101-2021_01_08_423993	631	42	Belohradsky	Belohradsky	NNP
10_1101-2021_01_08_423993	631	43	BH	BH	NNP
10_1101-2021_01_08_423993	631	44	,	,	,
10_1101-2021_01_08_423993	631	45	Albert	Albert	NNP
10_1101-2021_01_08_423993	631	46	MH	MH	NNP
10_1101-2021_01_08_423993	631	47	,	,	,
10_1101-2021_01_08_423993	631	48	Schulz	Schulz	NNP
10_1101-2021_01_08_423993	631	49	A	A	NNP
10_1101-2021_01_08_423993	631	50	,	,	,
10_1101-2021_01_08_423993	631	51	Ehl	Ehl	NNP
10_1101-2021_01_08_423993	631	52	S	S	NNP
10_1101-2021_01_08_423993	631	53	,	,	,
10_1101-2021_01_08_423993	631	54	Friedrich	Friedrich	NNP
10_1101-2021_01_08_423993	631	55	W	W	NNP
10_1101-2021_01_08_423993	631	56	&	&	CC
10_1101-2021_01_08_423993	631	57	Schwarz	Schwarz	NNP
10_1101-2021_01_08_423993	631	58	K	K	NNP
10_1101-2021_01_08_423993	631	59	(	(	-LRB-
10_1101-2021_01_08_423993	631	60	2010	2010	CD
10_1101-2021_01_08_423993	631	61	)	)	-RRB-
10_1101-2021_01_08_423993	631	62	The	the	DT
10_1101-2021_01_08_423993	631	63	most	most	RBS
10_1101-2021_01_08_423993	631	64	frequent	frequent	JJ
10_1101-2021_01_08_423993	631	65	DCLRE1C	dclre1c	NN
10_1101-2021_01_08_423993	631	66	(	(	-LRB-
10_1101-2021_01_08_423993	631	67	ARTEMIS	ARTEMIS	NNP
10_1101-2021_01_08_423993	631	68	)	)	-RRB-
10_1101-2021_01_08_423993	631	69	mutations	mutation	NNS
10_1101-2021_01_08_423993	631	70	are	be	VBP
10_1101-2021_01_08_423993	631	71	based	base	VBN
10_1101-2021_01_08_423993	631	72	on	on	IN
10_1101-2021_01_08_423993	631	73	homologous	homologous	JJ
10_1101-2021_01_08_423993	631	74	recombination	recombination	NN
10_1101-2021_01_08_423993	631	75	events	event	NNS
10_1101-2021_01_08_423993	631	76	.	.	.
10_1101-2021_01_08_423993	632	1	Hum	hum	UH
10_1101-2021_01_08_423993	632	2	.	.	.
10_1101-2021_01_08_423993	633	1	Mutat	Mutat	NNP
10_1101-2021_01_08_423993	633	2	.	.	.
10_1101-2021_01_08_423993	634	1	31	31	CD
10_1101-2021_01_08_423993	634	2	,	,	,
10_1101-2021_01_08_423993	634	3	197–207	197–207	CD
10_1101-2021_01_08_423993	634	4	.	.	.
10_1101-2021_01_08_423993	635	1	56	56	CD
10_1101-2021_01_08_423993	635	2	.	.	.
10_1101-2021_01_08_423993	636	1	Karim	Karim	NNP
10_1101-2021_01_08_423993	636	2	MF	MF	NNP
10_1101-2021_01_08_423993	636	3	,	,	,
10_1101-2021_01_08_423993	636	4	Liu	Liu	NNP
10_1101-2021_01_08_423993	636	5	S	S	NNP
10_1101-2021_01_08_423993	636	6	,	,	,
10_1101-2021_01_08_423993	636	7	Laciak	Laciak	NNP
10_1101-2021_01_08_423993	636	8	AR	AR	NNP
10_1101-2021_01_08_423993	636	9	,	,	,
10_1101-2021_01_08_423993	636	10	Volk	Volk	NNP
10_1101-2021_01_08_423993	636	11	L	L	NNP
10_1101-2021_01_08_423993	636	12	,	,	,
10_1101-2021_01_08_423993	636	13	Rosenblum	Rosenblum	NNP
10_1101-2021_01_08_423993	636	14	M	M	NNP
10_1101-2021_01_08_423993	636	15	,	,	,
10_1101-2021_01_08_423993	636	16	Lieber	Lieber	NNP
10_1101-2021_01_08_423993	636	17	MR	MR	NNP
10_1101-2021_01_08_423993	636	18	,	,	,
10_1101-2021_01_08_423993	636	19	Wu	Wu	NNP
10_1101-2021_01_08_423993	636	20	M	M	NNP
10_1101-2021_01_08_423993	636	21	,	,	,
10_1101-2021_01_08_423993	636	22	Curtis	Curtis	NNP
10_1101-2021_01_08_423993	636	23	R	R	NNP
10_1101-2021_01_08_423993	636	24	,	,	,
10_1101-2021_01_08_423993	636	25	Huang	Huang	NNP
10_1101-2021_01_08_423993	636	26	N	N	NNP
10_1101-2021_01_08_423993	636	27	,	,	,
10_1101-2021_01_08_423993	636	28	Carr	Carr	NNP
10_1101-2021_01_08_423993	636	29	G	G	NNP
10_1101-2021_01_08_423993	636	30	&	&	CC
10_1101-2021_01_08_423993	636	31	Zhu	Zhu	NNP
10_1101-2021_01_08_423993	636	32	G	G	NNP
10_1101-2021_01_08_423993	636	33	(	(	-LRB-
10_1101-2021_01_08_423993	636	34	2020	2020	CD
10_1101-2021_01_08_423993	636	35	)	)	-RRB-
10_1101-2021_01_08_423993	636	36	Structural	structural	JJ
10_1101-2021_01_08_423993	636	37	analysis	analysis	NN
10_1101-2021_01_08_423993	636	38	of	of	IN
10_1101-2021_01_08_423993	636	39	the	the	DT
10_1101-2021_01_08_423993	636	40	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	636	41	domain	domain	NN
10_1101-2021_01_08_423993	636	42	of	of	IN
10_1101-2021_01_08_423993	636	43	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	636	44	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	636	45	/	/	SYM
10_1101-2021_01_08_423993	636	46	SNM1C	snm1c	NN
10_1101-2021_01_08_423993	636	47	reveals	reveal	VBZ
10_1101-2021_01_08_423993	636	48	distinct	distinct	JJ
10_1101-2021_01_08_423993	636	49	structural	structural	JJ
10_1101-2021_01_08_423993	636	50	features	feature	NNS
10_1101-2021_01_08_423993	636	51	.	.	.
10_1101-2021_01_08_423993	637	1	J.	J.	NNP
10_1101-2021_01_08_423993	637	2	Biol	Biol	NNP
10_1101-2021_01_08_423993	637	3	.	.	.
10_1101-2021_01_08_423993	638	1	Chem	Chem	NNP
10_1101-2021_01_08_423993	638	2	.	.	.
10_1101-2021_01_08_423993	639	1	444	444	CD
10_1101-2021_01_08_423993	639	2	,	,	,
10_1101-2021_01_08_423993	639	3	jbc	jbc	NNP
10_1101-2021_01_08_423993	639	4	.	.	.
10_1101-2021_01_08_423993	639	5	RA120.014136	RA120.014136	NNP
10_1101-2021_01_08_423993	639	6	.	.	.
10_1101-2021_01_08_423993	640	1	57	57	CD
10_1101-2021_01_08_423993	640	2	.	.	.
10_1101-2021_01_08_423993	641	1	Ussery	Ussery	NNP
10_1101-2021_01_08_423993	641	2	DW	DW	NNP
10_1101-2021_01_08_423993	641	3	(	(	-LRB-
10_1101-2021_01_08_423993	641	4	2002	2002	CD
10_1101-2021_01_08_423993	641	5	)	)	-RRB-
10_1101-2021_01_08_423993	641	6	DNA	dna	NN
10_1101-2021_01_08_423993	641	7	Structure	structure	NN
10_1101-2021_01_08_423993	641	8	:	:	:
10_1101-2021_01_08_423993	641	9	A-	a-	XX
10_1101-2021_01_08_423993	641	10	,	,	,
10_1101-2021_01_08_423993	641	11	B-	b-	NN
10_1101-2021_01_08_423993	641	12	and	and	CC
10_1101-2021_01_08_423993	641	13	Z	Z	NNP
10_1101-2021_01_08_423993	641	14	-	-	HYPH
10_1101-2021_01_08_423993	641	15	DNA	dna	NN
10_1101-2021_01_08_423993	641	16	Helix	Helix	NNP
10_1101-2021_01_08_423993	641	17	Families	family	NNS
10_1101-2021_01_08_423993	641	18	.	.	.
10_1101-2021_01_08_423993	642	1	Encycl	Encycl	NNS
10_1101-2021_01_08_423993	642	2	.	.	.
10_1101-2021_01_08_423993	643	1	Life	Life	NNP
10_1101-2021_01_08_423993	643	2	Sci	Sci	NNP
10_1101-2021_01_08_423993	643	3	.	.	.
10_1101-2021_01_08_423993	644	1	58	58	CD
10_1101-2021_01_08_423993	644	2	.	.	.
10_1101-2021_01_08_423993	645	1	Elrod	Elrod	NNP
10_1101-2021_01_08_423993	645	2	-	-	HYPH
10_1101-2021_01_08_423993	645	3	Erickson	Erickson	NNP
10_1101-2021_01_08_423993	645	4	M	M	NNP
10_1101-2021_01_08_423993	645	5	,	,	,
10_1101-2021_01_08_423993	645	6	Rould	Rould	NNP
10_1101-2021_01_08_423993	645	7	MA	MA	NNP
10_1101-2021_01_08_423993	645	8	,	,	,
10_1101-2021_01_08_423993	645	9	Nekludova	Nekludova	NNP
10_1101-2021_01_08_423993	645	10	L	L	NNP
10_1101-2021_01_08_423993	645	11	&	&	CC
10_1101-2021_01_08_423993	645	12	Pabo	Pabo	NNP
10_1101-2021_01_08_423993	645	13	CO	CO	NNP
10_1101-2021_01_08_423993	645	14	(	(	-LRB-
10_1101-2021_01_08_423993	645	15	1996	1996	CD
10_1101-2021_01_08_423993	645	16	)	)	-RRB-
10_1101-2021_01_08_423993	645	17	Zif268	zif268	CD
10_1101-2021_01_08_423993	645	18	protein	protein	NN
10_1101-2021_01_08_423993	645	19	-	-	HYPH
10_1101-2021_01_08_423993	645	20	DNA	dna	NN
10_1101-2021_01_08_423993	645	21	complex	complex	NN
10_1101-2021_01_08_423993	645	22	refined	refine	VBN
10_1101-2021_01_08_423993	645	23	at	at	IN
10_1101-2021_01_08_423993	645	24	1.6	1.6	CD
10_1101-2021_01_08_423993	645	25	Å	å	NN
10_1101-2021_01_08_423993	645	26	:	:	:
10_1101-2021_01_08_423993	645	27	A	a	DT
10_1101-2021_01_08_423993	645	28	model	model	NN
10_1101-2021_01_08_423993	645	29	system	system	NN
10_1101-2021_01_08_423993	645	30	for	for	IN
10_1101-2021_01_08_423993	645	31	understanding	understand	VBG
10_1101-2021_01_08_423993	645	32	zinc	zinc	NN
10_1101-2021_01_08_423993	645	33	finger	finger	NN
10_1101-2021_01_08_423993	645	34	-	-	HYPH
10_1101-2021_01_08_423993	645	35	DNA	dna	NN
10_1101-2021_01_08_423993	645	36	interactions	interaction	NNS
10_1101-2021_01_08_423993	645	37	.	.	.
10_1101-2021_01_08_423993	646	1	Structure	structure	NN
10_1101-2021_01_08_423993	646	2	4	4	CD
10_1101-2021_01_08_423993	646	3	,	,	,
10_1101-2021_01_08_423993	646	4	1171–1180	1171–1180	CD
10_1101-2021_01_08_423993	646	5	.	.	.
10_1101-2021_01_08_423993	647	1	59	59	CD
10_1101-2021_01_08_423993	647	2	.	.	.
10_1101-2021_01_08_423993	648	1	Locasale	locasale	JJ
10_1101-2021_01_08_423993	648	2	JW	JW	NNP
10_1101-2021_01_08_423993	648	3	,	,	,
10_1101-2021_01_08_423993	648	4	Napoli	Napoli	NNP
10_1101-2021_01_08_423993	648	5	AA	AA	NNP
10_1101-2021_01_08_423993	648	6	,	,	,
10_1101-2021_01_08_423993	648	7	Chen	Chen	NNP
10_1101-2021_01_08_423993	648	8	S	S	NNP
10_1101-2021_01_08_423993	648	9	,	,	,
10_1101-2021_01_08_423993	648	10	Berman	Berman	NNP
10_1101-2021_01_08_423993	648	11	HM	HM	NNP
10_1101-2021_01_08_423993	648	12	&	&	CC
10_1101-2021_01_08_423993	648	13	Lawson	Lawson	NNP
10_1101-2021_01_08_423993	648	14	CL	CL	NNP
10_1101-2021_01_08_423993	648	15	(	(	-LRB-
10_1101-2021_01_08_423993	648	16	2009	2009	CD
10_1101-2021_01_08_423993	648	17	)	)	-RRB-
10_1101-2021_01_08_423993	648	18	Signatures	signature	NNS
10_1101-2021_01_08_423993	648	19	of	of	IN
10_1101-2021_01_08_423993	648	20	Protein-	Protein-	NNP
10_1101-2021_01_08_423993	648	21	DNA	DNA	NNP
10_1101-2021_01_08_423993	648	22	Recognition	Recognition	NNP
10_1101-2021_01_08_423993	648	23	in	in	IN
10_1101-2021_01_08_423993	648	24	Free	free	JJ
10_1101-2021_01_08_423993	648	25	DNA	dna	NN
10_1101-2021_01_08_423993	648	26	Binding	bind	VBG
10_1101-2021_01_08_423993	648	27	Sites	site	NNS
10_1101-2021_01_08_423993	648	28	.	.	.
10_1101-2021_01_08_423993	649	1	J.	J.	NNP
10_1101-2021_01_08_423993	649	2	Mol	Mol	NNP
10_1101-2021_01_08_423993	649	3	.	.	.
10_1101-2021_01_08_423993	650	1	Biol	Biol	NNP
10_1101-2021_01_08_423993	650	2	.	.	.
10_1101-2021_01_08_423993	651	1	386	386	CD
10_1101-2021_01_08_423993	651	2	,	,	,
10_1101-2021_01_08_423993	651	3	1054–1065	1054–1065	CD
10_1101-2021_01_08_423993	651	4	.	.	.
10_1101-2021_01_08_423993	652	1	60	60	CD
10_1101-2021_01_08_423993	652	2	.	.	.
10_1101-2021_01_08_423993	653	1	Mandel	Mandel	NNP
10_1101-2021_01_08_423993	653	2	CR	CR	NNP
10_1101-2021_01_08_423993	653	3	,	,	,
10_1101-2021_01_08_423993	653	4	Kaneko	Kaneko	NNP
10_1101-2021_01_08_423993	653	5	S	S	NNP
10_1101-2021_01_08_423993	653	6	,	,	,
10_1101-2021_01_08_423993	653	7	Zhang	Zhang	NNP
10_1101-2021_01_08_423993	653	8	H	H	NNP
10_1101-2021_01_08_423993	653	9	,	,	,
10_1101-2021_01_08_423993	653	10	Gebauer	Gebauer	NNP
10_1101-2021_01_08_423993	653	11	D	D	NNP
10_1101-2021_01_08_423993	653	12	,	,	,
10_1101-2021_01_08_423993	653	13	Vethantham	Vethantham	NNP
10_1101-2021_01_08_423993	653	14	V	V	NNP
10_1101-2021_01_08_423993	653	15	,	,	,
10_1101-2021_01_08_423993	653	16	Manley	Manley	NNP
10_1101-2021_01_08_423993	653	17	JL	JL	NNP
10_1101-2021_01_08_423993	653	18	&	&	CC
10_1101-2021_01_08_423993	653	19	Tong	Tong	NNP
10_1101-2021_01_08_423993	653	20	L	L	NNP
10_1101-2021_01_08_423993	653	21	(	(	-LRB-
10_1101-2021_01_08_423993	653	22	2006	2006	CD
10_1101-2021_01_08_423993	653	23	)	)	-RRB-
10_1101-2021_01_08_423993	653	24	Polyadenylation	polyadenylation	NN
10_1101-2021_01_08_423993	653	25	factor	factor	NN
10_1101-2021_01_08_423993	653	26	CPSF-73	CPSF-73	,
10_1101-2021_01_08_423993	653	27	is	be	VBZ
10_1101-2021_01_08_423993	653	28	the	the	DT
10_1101-2021_01_08_423993	653	29	pre	pre	NN
10_1101-2021_01_08_423993	653	30	-	-	JJ
10_1101-2021_01_08_423993	653	31	mRNA	mrna	JJ
10_1101-2021_01_08_423993	653	32	3’-end	3’-end	NN
10_1101-2021_01_08_423993	653	33	-	-	HYPH
10_1101-2021_01_08_423993	653	34	processing	process	VBG
10_1101-2021_01_08_423993	653	35	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	653	36	.	.	.
10_1101-2021_01_08_423993	654	1	Nature	nature	NN
10_1101-2021_01_08_423993	654	2	444	444	CD
10_1101-2021_01_08_423993	654	3	,	,	,
10_1101-2021_01_08_423993	654	4	953–956	953–956	CD
10_1101-2021_01_08_423993	654	5	.	.	.
10_1101-2021_01_08_423993	655	1	61	61	CD
10_1101-2021_01_08_423993	655	2	.	.	.
10_1101-2021_01_08_423993	656	1	Poinsignon	Poinsignon	NNP
10_1101-2021_01_08_423993	656	2	C	C	NNP
10_1101-2021_01_08_423993	656	3	,	,	,
10_1101-2021_01_08_423993	656	4	Moshous	Moshous	NNP
10_1101-2021_01_08_423993	656	5	D	D	NNP
10_1101-2021_01_08_423993	656	6	,	,	,
10_1101-2021_01_08_423993	656	7	Callebaut	Callebaut	NNP
10_1101-2021_01_08_423993	656	8	I	I	NNP
10_1101-2021_01_08_423993	656	9	,	,	,
10_1101-2021_01_08_423993	656	10	De	De	NNP
10_1101-2021_01_08_423993	656	11	Chasseval	Chasseval	NNP
10_1101-2021_01_08_423993	656	12	R	R	NNP
10_1101-2021_01_08_423993	656	13	,	,	,
10_1101-2021_01_08_423993	656	14	Villey	Villey	NNP
10_1101-2021_01_08_423993	656	15	I	I	NNP
10_1101-2021_01_08_423993	656	16	&	&	CC
10_1101-2021_01_08_423993	656	17	De	De	NNP
10_1101-2021_01_08_423993	656	18	Villartay	Villartay	NNP
10_1101-2021_01_08_423993	656	19	JP	JP	NNP
10_1101-2021_01_08_423993	656	20	(	(	-LRB-
10_1101-2021_01_08_423993	656	21	2004	2004	CD
10_1101-2021_01_08_423993	656	22	)	)	-RRB-
10_1101-2021_01_08_423993	656	23	The	the	DT
10_1101-2021_01_08_423993	656	24	Metallo	Metallo	NNP
10_1101-2021_01_08_423993	656	25	-	-	HYPH
10_1101-2021_01_08_423993	656	26	β	β	NNP
10_1101-2021_01_08_423993	656	27	-	-	HYPH
10_1101-2021_01_08_423993	656	28	Lactamase	Lactamase	NNP
10_1101-2021_01_08_423993	656	29	/	/	SYM
10_1101-2021_01_08_423993	656	30	β	β	NNP
10_1101-2021_01_08_423993	656	31	-	-	HYPH
10_1101-2021_01_08_423993	656	32	CASP	CASP	NNP
10_1101-2021_01_08_423993	656	33	Domain	Domain	NNP
10_1101-2021_01_08_423993	656	34	of	of	IN
10_1101-2021_01_08_423993	656	35	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	656	36	Constitutes	constitute	VBZ
10_1101-2021_01_08_423993	656	37	the	the	DT
10_1101-2021_01_08_423993	656	38	Catalytic	catalytic	JJ
10_1101-2021_01_08_423993	656	39	Core	Core	NNP
10_1101-2021_01_08_423993	656	40	for	for	IN
10_1101-2021_01_08_423993	656	41	V(D)J	V(D)J	NNP
10_1101-2021_01_08_423993	656	42	Recombination	Recombination	NNP
10_1101-2021_01_08_423993	656	43	.	.	.
10_1101-2021_01_08_423993	657	1	J.	J.	NNP
10_1101-2021_01_08_423993	657	2	Exp	Exp	NNP
10_1101-2021_01_08_423993	657	3	.	.	.
10_1101-2021_01_08_423993	658	1	Med	Med	NNP
10_1101-2021_01_08_423993	658	2	.	.	.
10_1101-2021_01_08_423993	659	1	199	199	CD
10_1101-2021_01_08_423993	659	2	,	,	,
10_1101-2021_01_08_423993	659	3	315–321	315–321	CD
10_1101-2021_01_08_423993	659	4	.	.	.
10_1101-2021_01_08_423993	660	1	62	62	CD
10_1101-2021_01_08_423993	660	2	.	.	.
10_1101-2021_01_08_423993	661	1	Jekimovs	Jekimovs	NNP
10_1101-2021_01_08_423993	661	2	C	C	NNP
10_1101-2021_01_08_423993	661	3	,	,	,
10_1101-2021_01_08_423993	661	4	Bolderson	Bolderson	NNP
10_1101-2021_01_08_423993	661	5	E	E	NNP
10_1101-2021_01_08_423993	661	6	,	,	,
10_1101-2021_01_08_423993	661	7	Suraweera	Suraweera	NNP
10_1101-2021_01_08_423993	661	8	A	A	NNP
10_1101-2021_01_08_423993	661	9	,	,	,
10_1101-2021_01_08_423993	661	10	Adams	Adams	NNP
10_1101-2021_01_08_423993	661	11	M	M	NNP
10_1101-2021_01_08_423993	661	12	,	,	,
10_1101-2021_01_08_423993	661	13	O’Byrne	O’Byrne	NNP
10_1101-2021_01_08_423993	661	14	KJ	KJ	NNP
10_1101-2021_01_08_423993	661	15	&	&	CC
10_1101-2021_01_08_423993	661	16	Richard	Richard	NNP
10_1101-2021_01_08_423993	661	17	DJ	DJ	NNP
10_1101-2021_01_08_423993	661	18	(	(	-LRB-
10_1101-2021_01_08_423993	661	19	2014	2014	CD
10_1101-2021_01_08_423993	661	20	)	)	-RRB-
10_1101-2021_01_08_423993	661	21	Chemotherapeutic	chemotherapeutic	JJ
10_1101-2021_01_08_423993	661	22	compounds	compound	NNS
10_1101-2021_01_08_423993	661	23	targeting	target	VBG
10_1101-2021_01_08_423993	661	24	the	the	DT
10_1101-2021_01_08_423993	661	25	DNA	DNA	NNP
10_1101-2021_01_08_423993	661	26	double	double	JJ
10_1101-2021_01_08_423993	661	27	-	-	HYPH
10_1101-2021_01_08_423993	661	28	strand	strand	NN
10_1101-2021_01_08_423993	661	29	break	break	NN
10_1101-2021_01_08_423993	661	30	repair	repair	NN
10_1101-2021_01_08_423993	661	31	pathways	pathway	NNS
10_1101-2021_01_08_423993	661	32	:	:	:
10_1101-2021_01_08_423993	661	33	The	the	DT
10_1101-2021_01_08_423993	661	34	good	good	JJ
10_1101-2021_01_08_423993	661	35	,	,	,
10_1101-2021_01_08_423993	661	36	the	the	DT
10_1101-2021_01_08_423993	661	37	bad	bad	JJ
10_1101-2021_01_08_423993	661	38	,	,	,
10_1101-2021_01_08_423993	661	39	and	and	CC
10_1101-2021_01_08_423993	661	40	the	the	DT
10_1101-2021_01_08_423993	661	41	promising	promising	NN
10_1101-2021_01_08_423993	661	42	.	.	.
10_1101-2021_01_08_423993	662	1	Front	front	NN
10_1101-2021_01_08_423993	662	2	.	.	.
10_1101-2021_01_08_423993	663	1	Oncol	Oncol	NNP
10_1101-2021_01_08_423993	663	2	.	.	.
10_1101-2021_01_08_423993	664	1	4	4	CD
10_1101-2021_01_08_423993	664	2	APR	APR	NNP
10_1101-2021_01_08_423993	664	3	,	,	,
10_1101-2021_01_08_423993	664	4	1–18	1–18	CD
10_1101-2021_01_08_423993	664	5	.	.	.
10_1101-2021_01_08_423993	665	1	63	63	CD
10_1101-2021_01_08_423993	665	2	.	.	.
10_1101-2021_01_08_423993	666	1	Shibata	Shibata	NNP
10_1101-2021_01_08_423993	666	2	A	A	NNP
10_1101-2021_01_08_423993	666	3	&	&	CC
10_1101-2021_01_08_423993	666	4	Jeggo	Jeggo	NNP
10_1101-2021_01_08_423993	666	5	P	P	NNP
10_1101-2021_01_08_423993	666	6	(	(	-LRB-
10_1101-2021_01_08_423993	666	7	2019	2019	CD
10_1101-2021_01_08_423993	666	8	)	)	-RRB-
10_1101-2021_01_08_423993	666	9	A	a	DT
10_1101-2021_01_08_423993	666	10	historical	historical	JJ
10_1101-2021_01_08_423993	666	11	reflection	reflection	NN
10_1101-2021_01_08_423993	666	12	on	on	IN
10_1101-2021_01_08_423993	666	13	our	-PRON-	PRP$
10_1101-2021_01_08_423993	666	14	understanding	understanding	NN
10_1101-2021_01_08_423993	666	15	of	of	IN
10_1101-2021_01_08_423993	666	16	radiation-	radiation-	NNP
10_1101-2021_01_08_423993	666	17	induced	induce	VBN
10_1101-2021_01_08_423993	666	18	DNA	DNA	NNP
10_1101-2021_01_08_423993	666	19	double	double	JJ
10_1101-2021_01_08_423993	666	20	strand	strand	NN
10_1101-2021_01_08_423993	666	21	break	break	NN
10_1101-2021_01_08_423993	666	22	repair	repair	NN
10_1101-2021_01_08_423993	666	23	in	in	IN
10_1101-2021_01_08_423993	666	24	somatic	somatic	JJ
10_1101-2021_01_08_423993	666	25	mammalian	mammalian	JJ
10_1101-2021_01_08_423993	666	26	cells	cell	NNS
10_1101-2021_01_08_423993	666	27	;	;	,
10_1101-2021_01_08_423993	666	28	interfacing	interface	VBG
10_1101-2021_01_08_423993	666	29	the	the	DT
10_1101-2021_01_08_423993	666	30	past	past	NN
10_1101-2021_01_08_423993	666	31	with	with	IN
10_1101-2021_01_08_423993	666	32	the	the	DT
10_1101-2021_01_08_423993	666	33	present	present	NN
10_1101-2021_01_08_423993	666	34	.	.	.
10_1101-2021_01_08_423993	667	1	Int	Int	NNP
10_1101-2021_01_08_423993	667	2	.	.	.
10_1101-2021_01_08_423993	668	1	J.	J.	NNP
10_1101-2021_01_08_423993	668	2	Radiat	Radiat	NNP
10_1101-2021_01_08_423993	668	3	.	.	.
10_1101-2021_01_08_423993	669	1	Biol	Biol	NNP
10_1101-2021_01_08_423993	669	2	.	.	.
10_1101-2021_01_08_423993	670	1	95	95	CD
10_1101-2021_01_08_423993	670	2	,	,	,
10_1101-2021_01_08_423993	670	3	945–956	945–956	CD
10_1101-2021_01_08_423993	670	4	.	.	.
10_1101-2021_01_08_423993	671	1	64	64	CD
10_1101-2021_01_08_423993	671	2	.	.	.
10_1101-2021_01_08_423993	672	1	Weterings	wetering	NNS
10_1101-2021_01_08_423993	672	2	E	E	NNP
10_1101-2021_01_08_423993	672	3	,	,	,
10_1101-2021_01_08_423993	672	4	Gallegos	Gallegos	NNP
10_1101-2021_01_08_423993	672	5	AC	AC	NNP
10_1101-2021_01_08_423993	672	6	,	,	,
10_1101-2021_01_08_423993	672	7	Dominick	Dominick	NNP
10_1101-2021_01_08_423993	672	8	LN	LN	NNP
10_1101-2021_01_08_423993	672	9	,	,	,
10_1101-2021_01_08_423993	672	10	Cooke	Cooke	NNP
10_1101-2021_01_08_423993	672	11	LS	LS	NNP
10_1101-2021_01_08_423993	672	12	,	,	,
10_1101-2021_01_08_423993	672	13	Bartels	Bartels	NNP
10_1101-2021_01_08_423993	672	14	TN	TN	NNP
10_1101-2021_01_08_423993	672	15	,	,	,
10_1101-2021_01_08_423993	672	16	Vagner	Vagner	NNP
10_1101-2021_01_08_423993	672	17	J	J	NNP
10_1101-2021_01_08_423993	672	18	,	,	,
10_1101-2021_01_08_423993	672	19	Matsunaga	Matsunaga	NNP
10_1101-2021_01_08_423993	672	20	TO	to	IN
10_1101-2021_01_08_423993	672	21	&	&	CC
10_1101-2021_01_08_423993	672	22	Mahadevan	Mahadevan	NNP
10_1101-2021_01_08_423993	672	23	D	D	NNP
10_1101-2021_01_08_423993	672	24	(	(	-LRB-
10_1101-2021_01_08_423993	672	25	2016	2016	CD
10_1101-2021_01_08_423993	672	26	)	)	-RRB-
10_1101-2021_01_08_423993	672	27	A	a	DT
10_1101-2021_01_08_423993	672	28	novel	novel	JJ
10_1101-2021_01_08_423993	672	29	small	small	JJ
10_1101-2021_01_08_423993	672	30	molecule	molecule	NN
10_1101-2021_01_08_423993	672	31	inhibitor	inhibitor	NN
10_1101-2021_01_08_423993	672	32	of	of	IN
10_1101-2021_01_08_423993	672	33	the	the	DT
10_1101-2021_01_08_423993	672	34	DNA	DNA	NNP
10_1101-2021_01_08_423993	672	35	repair	repair	NN
10_1101-2021_01_08_423993	672	36	protein	protein	NN
10_1101-2021_01_08_423993	672	37	Ku70/80	ku70/80	NN
10_1101-2021_01_08_423993	672	38	.	.	.
10_1101-2021_01_08_423993	673	1	DNA	DNA	NNP
10_1101-2021_01_08_423993	673	2	Repair	Repair	NNP
10_1101-2021_01_08_423993	673	3	(	(	-LRB-
10_1101-2021_01_08_423993	673	4	Amst	Amst	NNP
10_1101-2021_01_08_423993	673	5	)	)	-RRB-
10_1101-2021_01_08_423993	673	6	.	.	.
10_1101-2021_01_08_423993	674	1	43	43	CD
10_1101-2021_01_08_423993	674	2	,	,	,
10_1101-2021_01_08_423993	674	3	98–106	98–106	CD
10_1101-2021_01_08_423993	674	4	.	.	.
10_1101-2021_01_08_423993	675	1	65	65	CD
10_1101-2021_01_08_423993	675	2	.	.	.
10_1101-2021_01_08_423993	676	1	Jin	Jin	NNP
10_1101-2021_01_08_423993	676	2	MH	MH	NNP
10_1101-2021_01_08_423993	676	3	&	&	CC
10_1101-2021_01_08_423993	676	4	Oh	oh	UH
10_1101-2021_01_08_423993	676	5	DY	DY	NNP
10_1101-2021_01_08_423993	676	6	(	(	-LRB-
10_1101-2021_01_08_423993	676	7	2019	2019	CD
10_1101-2021_01_08_423993	676	8	)	)	-RRB-
10_1101-2021_01_08_423993	676	9	ATM	ATM	NNS
10_1101-2021_01_08_423993	676	10	in	in	IN
10_1101-2021_01_08_423993	676	11	DNA	dna	NN
10_1101-2021_01_08_423993	676	12	repair	repair	NN
10_1101-2021_01_08_423993	676	13	in	in	IN
10_1101-2021_01_08_423993	676	14	cancer	cancer	NN
10_1101-2021_01_08_423993	676	15	.	.	.
10_1101-2021_01_08_423993	677	1	Pharmacol	Pharmacol	NNP
10_1101-2021_01_08_423993	677	2	.	.	.
10_1101-2021_01_08_423993	678	1	Ther	ther	RB
10_1101-2021_01_08_423993	678	2	.	.	.
10_1101-2021_01_08_423993	679	1	203	203	CD
10_1101-2021_01_08_423993	679	2	,	,	,
10_1101-2021_01_08_423993	679	3	107391	107391	CD
10_1101-2021_01_08_423993	679	4	.	.	.
10_1101-2021_01_08_423993	680	1	66	66	CD
10_1101-2021_01_08_423993	680	2	.	.	.
10_1101-2021_01_08_423993	681	1	Lee	Lee	NNP
10_1101-2021_01_08_423993	681	2	SY	SY	NNP
10_1101-2021_01_08_423993	681	3	,	,	,
10_1101-2021_01_08_423993	681	4	Brem	Brem	NNP
10_1101-2021_01_08_423993	681	5	J	J	NNP
10_1101-2021_01_08_423993	681	6	,	,	,
10_1101-2021_01_08_423993	681	7	Pettinati	Pettinati	NNP
10_1101-2021_01_08_423993	681	8	I	I	NNP
10_1101-2021_01_08_423993	681	9	,	,	,
10_1101-2021_01_08_423993	681	10	Claridge	Claridge	NNP
10_1101-2021_01_08_423993	681	11	TDW	TDW	NNP
10_1101-2021_01_08_423993	681	12	,	,	,
10_1101-2021_01_08_423993	681	13	Gileadi	Gileadi	NNP
10_1101-2021_01_08_423993	681	14	O	O	NNP
10_1101-2021_01_08_423993	681	15	,	,	,
10_1101-2021_01_08_423993	681	16	Schofield	Schofield	NNP
10_1101-2021_01_08_423993	681	17	CJ	CJ	NNP
10_1101-2021_01_08_423993	681	18	&	&	CC
10_1101-2021_01_08_423993	681	19	McHugh	McHugh	NNP
10_1101-2021_01_08_423993	681	20	PJ	PJ	NNP
10_1101-2021_01_08_423993	681	21	(	(	-LRB-
10_1101-2021_01_08_423993	681	22	2016	2016	CD
10_1101-2021_01_08_423993	681	23	)	)	-RRB-
10_1101-2021_01_08_423993	681	24	Cephalosporins	cephalosporin	NNS
10_1101-2021_01_08_423993	681	25	inhibit	inhibit	VBP
10_1101-2021_01_08_423993	681	26	human	human	JJ
10_1101-2021_01_08_423993	681	27	metallo	metallo	NN
10_1101-2021_01_08_423993	681	28	β	β	NN
10_1101-2021_01_08_423993	681	29	-	-	HYPH
10_1101-2021_01_08_423993	681	30	lactamase	lactamase	NNP
10_1101-2021_01_08_423993	681	31	fold	fold	VB
10_1101-2021_01_08_423993	681	32	DNA	dna	NN
10_1101-2021_01_08_423993	681	33	repair	repair	NN
10_1101-2021_01_08_423993	681	34	nucleases	nuclease	NNS
10_1101-2021_01_08_423993	681	35	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	681	36	and	and	CC
10_1101-2021_01_08_423993	681	37	SNM1B	SNM1B	NNP
10_1101-2021_01_08_423993	681	38	/	/	SYM
10_1101-2021_01_08_423993	681	39	apollo	apollo	NN
10_1101-2021_01_08_423993	681	40	.	.	.
10_1101-2021_01_08_423993	682	1	Chem	Chem	NNP
10_1101-2021_01_08_423993	682	2	.	.	.
10_1101-2021_01_08_423993	683	1	Commun	Commun	VBN
10_1101-2021_01_08_423993	683	2	.	.	.
10_1101-2021_01_08_423993	684	1	52	52	CD
10_1101-2021_01_08_423993	684	2	,	,	,
10_1101-2021_01_08_423993	684	3	6727–6730	6727–6730	CD
10_1101-2021_01_08_423993	684	4	.	.	.
10_1101-2021_01_08_423993	685	1	67	67	CD
10_1101-2021_01_08_423993	685	2	.	.	.
10_1101-2021_01_08_423993	686	1	Palzkill	Palzkill	NNP
10_1101-2021_01_08_423993	686	2	T	T	NNP
10_1101-2021_01_08_423993	686	3	(	(	-LRB-
10_1101-2021_01_08_423993	686	4	2013	2013	CD
10_1101-2021_01_08_423993	686	5	)	)	-RRB-
10_1101-2021_01_08_423993	686	6	Metallo	Metallo	NNP
10_1101-2021_01_08_423993	686	7	-	-	HYPH
10_1101-2021_01_08_423993	686	8	β	β	NNP
10_1101-2021_01_08_423993	686	9	-	-	HYPH
10_1101-2021_01_08_423993	686	10	lactamase	lactamase	NN
10_1101-2021_01_08_423993	686	11	structure	structure	NN
10_1101-2021_01_08_423993	686	12	and	and	CC
10_1101-2021_01_08_423993	686	13	function	function	NN
10_1101-2021_01_08_423993	686	14	.	.	.
10_1101-2021_01_08_423993	687	1	Ann	Ann	NNP
10_1101-2021_01_08_423993	687	2	.	.	.
10_1101-2021_01_08_423993	688	1	N.	N.	NNP
10_1101-2021_01_08_423993	688	2	Y.	Y.	NNP
10_1101-2021_01_08_423993	688	3	Acad	Acad	NNP
10_1101-2021_01_08_423993	688	4	.	.	.
10_1101-2021_01_08_423993	689	1	Sci	Sci	NNP
10_1101-2021_01_08_423993	689	2	.	.	.
10_1101-2021_01_08_423993	690	1	1277	1277	CD
10_1101-2021_01_08_423993	690	2	,	,	,
10_1101-2021_01_08_423993	690	3	91–104	91–104	CD
10_1101-2021_01_08_423993	690	4	.	.	.
10_1101-2021_01_08_423993	691	1	68	68	CD
10_1101-2021_01_08_423993	691	2	.	.	.
10_1101-2021_01_08_423993	692	1	Spraggon	Spraggon	NNP
10_1101-2021_01_08_423993	692	2	G	G	NNP
10_1101-2021_01_08_423993	692	3	,	,	,
10_1101-2021_01_08_423993	692	4	Koesema	Koesema	NNP
10_1101-2021_01_08_423993	692	5	E	E	NNP
10_1101-2021_01_08_423993	692	6	,	,	,
10_1101-2021_01_08_423993	692	7	Scarselli	Scarselli	NNP
10_1101-2021_01_08_423993	692	8	M	M	NNP
10_1101-2021_01_08_423993	692	9	,	,	,
10_1101-2021_01_08_423993	692	10	Malito	Malito	NNP
10_1101-2021_01_08_423993	692	11	E	E	NNP
10_1101-2021_01_08_423993	692	12	,	,	,
10_1101-2021_01_08_423993	692	13	Biagini	Biagini	NNP
10_1101-2021_01_08_423993	692	14	M	M	NNP
10_1101-2021_01_08_423993	692	15	,	,	,
10_1101-2021_01_08_423993	692	16	Norais	Norais	NNP
10_1101-2021_01_08_423993	692	17	N	N	NNP
10_1101-2021_01_08_423993	692	18	,	,	,
10_1101-2021_01_08_423993	692	19	Emolo	Emolo	NNP
10_1101-2021_01_08_423993	692	20	C	C	NNP
10_1101-2021_01_08_423993	692	21	,	,	,
10_1101-2021_01_08_423993	692	22	Barocchi	Barocchi	NNP
10_1101-2021_01_08_423993	692	23	MA	MA	NNP
10_1101-2021_01_08_423993	692	24	,	,	,
10_1101-2021_01_08_423993	692	25	Giusti	Giusti	NNP
10_1101-2021_01_08_423993	692	26	F	F	NNP
10_1101-2021_01_08_423993	692	27	,	,	,
10_1101-2021_01_08_423993	692	28	Hilleringmann	Hilleringmann	NNP
10_1101-2021_01_08_423993	692	29	M	M	NNP
10_1101-2021_01_08_423993	692	30	,	,	,
10_1101-2021_01_08_423993	692	31	Rappuoli	Rappuoli	NNP
10_1101-2021_01_08_423993	692	32	R	R	NNP
10_1101-2021_01_08_423993	692	33	,	,	,
10_1101-2021_01_08_423993	692	34	Lesley	Lesley	NNP
10_1101-2021_01_08_423993	692	35	S	S	NNP
10_1101-2021_01_08_423993	692	36	,	,	,
10_1101-2021_01_08_423993	692	37	Covacci	Covacci	NNP
10_1101-2021_01_08_423993	692	38	A	A	NNP
10_1101-2021_01_08_423993	692	39	,	,	,
10_1101-2021_01_08_423993	692	40	Masignani	Masignani	NNP
10_1101-2021_01_08_423993	692	41	V	V	NNP
10_1101-2021_01_08_423993	692	42	&	&	CC
10_1101-2021_01_08_423993	692	43	Ferlenghi	Ferlenghi	NNP
10_1101-2021_01_08_423993	692	44	I	-PRON-	PRP
10_1101-2021_01_08_423993	692	45	(	(	-LRB-
10_1101-2021_01_08_423993	692	46	2010	2010	CD
10_1101-2021_01_08_423993	692	47	)	)	-RRB-
10_1101-2021_01_08_423993	692	48	Supramolecular	supramolecular	JJ
10_1101-2021_01_08_423993	692	49	organization	organization	NN
10_1101-2021_01_08_423993	692	50	of	of	IN
10_1101-2021_01_08_423993	692	51	the	the	DT
10_1101-2021_01_08_423993	692	52	repetitive	repetitive	JJ
10_1101-2021_01_08_423993	692	53	backbone	backbone	NN
10_1101-2021_01_08_423993	692	54	unit	unit	NN
10_1101-2021_01_08_423993	692	55	of	of	IN
10_1101-2021_01_08_423993	692	56	the	the	DT
10_1101-2021_01_08_423993	692	57	Streptococcus	Streptococcus	NNP
10_1101-2021_01_08_423993	692	58	pneumoniae	pneumoniae	NN
10_1101-2021_01_08_423993	692	59	pilus	pilus	NN
10_1101-2021_01_08_423993	692	60	.	.	.
10_1101-2021_01_08_423993	693	1	PLoS	plos	ADD
10_1101-2021_01_08_423993	693	2	One	one	CD
10_1101-2021_01_08_423993	693	3	5	5	CD
10_1101-2021_01_08_423993	693	4	.	.	.
10_1101-2021_01_08_423993	694	1	.CC	.CC	NFP
10_1101-2021_01_08_423993	694	2	-	-	:
10_1101-2021_01_08_423993	694	3	BY	by	IN
10_1101-2021_01_08_423993	694	4	4.0	4.0	CD
10_1101-2021_01_08_423993	694	5	International	international	JJ
10_1101-2021_01_08_423993	694	6	licensemade	licensemade	NN
10_1101-2021_01_08_423993	694	7	available	available	JJ
10_1101-2021_01_08_423993	694	8	under	under	IN
10_1101-2021_01_08_423993	694	9	a	a	DT
10_1101-2021_01_08_423993	694	10	(	(	-LRB-
10_1101-2021_01_08_423993	694	11	which	which	WDT
10_1101-2021_01_08_423993	694	12	was	be	VBD
10_1101-2021_01_08_423993	694	13	not	not	RB
10_1101-2021_01_08_423993	694	14	certified	certify	VBN
10_1101-2021_01_08_423993	694	15	by	by	IN
10_1101-2021_01_08_423993	694	16	peer	peer	NN
10_1101-2021_01_08_423993	694	17	review	review	NN
10_1101-2021_01_08_423993	694	18	)	)	-RRB-
10_1101-2021_01_08_423993	694	19	is	be	VBZ
10_1101-2021_01_08_423993	694	20	the	the	DT
10_1101-2021_01_08_423993	694	21	author	author	NN
10_1101-2021_01_08_423993	694	22	/	/	SYM
10_1101-2021_01_08_423993	694	23	funder	funder	NN
10_1101-2021_01_08_423993	694	24	,	,	,
10_1101-2021_01_08_423993	694	25	who	who	WP
10_1101-2021_01_08_423993	694	26	has	have	VBZ
10_1101-2021_01_08_423993	694	27	granted	grant	VBN
10_1101-2021_01_08_423993	694	28	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	694	29	a	a	DT
10_1101-2021_01_08_423993	694	30	license	license	NN
10_1101-2021_01_08_423993	694	31	to	to	TO
10_1101-2021_01_08_423993	694	32	display	display	VB
10_1101-2021_01_08_423993	694	33	the	the	DT
10_1101-2021_01_08_423993	694	34	preprint	preprint	NN
10_1101-2021_01_08_423993	694	35	in	in	IN
10_1101-2021_01_08_423993	694	36	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	694	37	.	.	.
10_1101-2021_01_08_423993	695	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	695	2	is	be	VBZ
10_1101-2021_01_08_423993	695	3	The	the	DT
10_1101-2021_01_08_423993	695	4	copyright	copyright	NN
10_1101-2021_01_08_423993	695	5	holder	holder	NN
10_1101-2021_01_08_423993	695	6	for	for	IN
10_1101-2021_01_08_423993	695	7	this	this	DT
10_1101-2021_01_08_423993	695	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	695	9	version	version	NN
10_1101-2021_01_08_423993	695	10	posted	post	VBD
10_1101-2021_01_08_423993	695	11	January	January	NNP
10_1101-2021_01_08_423993	695	12	8	8	CD
10_1101-2021_01_08_423993	695	13	,	,	,
10_1101-2021_01_08_423993	695	14	2021	2021	CD
10_1101-2021_01_08_423993	695	15	.	.	.
10_1101-2021_01_08_423993	695	16	;	;	:
10_1101-2021_01_08_423993	695	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	695	18	:	:	:
10_1101-2021_01_08_423993	695	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	695	20	preprint	preprint	NN
10_1101-2021_01_08_423993	695	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	NNP
10_1101-2021_01_08_423993	695	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2021_01_08_423993	695	23	69	69	CD
10_1101-2021_01_08_423993	695	24	.	.	.
10_1101-2021_01_08_423993	696	1	Abbehausen	Abbehausen	NNP
10_1101-2021_01_08_423993	696	2	C	C	NNP
10_1101-2021_01_08_423993	696	3	(	(	-LRB-
10_1101-2021_01_08_423993	696	4	2019	2019	CD
10_1101-2021_01_08_423993	696	5	)	)	-RRB-
10_1101-2021_01_08_423993	696	6	Zinc	Zinc	NNP
10_1101-2021_01_08_423993	696	7	finger	finger	NN
10_1101-2021_01_08_423993	696	8	domains	domain	NNS
10_1101-2021_01_08_423993	696	9	as	as	IN
10_1101-2021_01_08_423993	696	10	therapeutic	therapeutic	JJ
10_1101-2021_01_08_423993	696	11	targets	target	NNS
10_1101-2021_01_08_423993	696	12	for	for	IN
10_1101-2021_01_08_423993	696	13	metal	metal	NN
10_1101-2021_01_08_423993	696	14	-	-	HYPH
10_1101-2021_01_08_423993	696	15	based	base	VBN
10_1101-2021_01_08_423993	696	16	compounds	compound	NNS
10_1101-2021_01_08_423993	696	17	-	-	:
10_1101-2021_01_08_423993	696	18	an	an	DT
10_1101-2021_01_08_423993	696	19	update	update	NN
10_1101-2021_01_08_423993	696	20	.	.	.
10_1101-2021_01_08_423993	697	1	11	11	CD
10_1101-2021_01_08_423993	697	2	.	.	.
10_1101-2021_01_08_423993	698	1	70	70	CD
10_1101-2021_01_08_423993	698	2	.	.	.
10_1101-2021_01_08_423993	699	1	Chen	Chen	NNP
10_1101-2021_01_08_423993	699	2	S	S	NNP
10_1101-2021_01_08_423993	699	3	,	,	,
10_1101-2021_01_08_423993	699	4	Jeng	Jeng	NNP
10_1101-2021_01_08_423993	699	5	K	K	NNP
10_1101-2021_01_08_423993	699	6	&	&	CC
10_1101-2021_01_08_423993	699	7	Lai	Lai	NNP
10_1101-2021_01_08_423993	699	8	MMC	MMC	NNP
10_1101-2021_01_08_423993	699	9	(	(	-LRB-
10_1101-2021_01_08_423993	699	10	2017	2017	CD
10_1101-2021_01_08_423993	699	11	)	)	-RRB-
10_1101-2021_01_08_423993	699	12	Zinc	Zinc	NNP
10_1101-2021_01_08_423993	699	13	Finger	Finger	NNP
10_1101-2021_01_08_423993	699	14	-	-	HYPH
10_1101-2021_01_08_423993	699	15	Containing	Containing	NNP
10_1101-2021_01_08_423993	699	16	Cellular	Cellular	NNP
10_1101-2021_01_08_423993	699	17	Transcription	Transcription	NNP
10_1101-2021_01_08_423993	699	18	Corepressor	Corepressor	NNP
10_1101-2021_01_08_423993	699	19	ZBTB25	ZBTB25	NNP
10_1101-2021_01_08_423993	699	20	Promotes	promote	VBZ
10_1101-2021_01_08_423993	699	21	Influenza	Influenza	NNP
10_1101-2021_01_08_423993	699	22	Virus	Virus	NNP
10_1101-2021_01_08_423993	699	23	RNA	RNA	NNP
10_1101-2021_01_08_423993	699	24	Transcription	Transcription	NNP
10_1101-2021_01_08_423993	699	25	and	and	CC
10_1101-2021_01_08_423993	699	26	Is	be	VBZ
10_1101-2021_01_08_423993	699	27	a	a	DT
10_1101-2021_01_08_423993	699	28	Target	Target	NNP
10_1101-2021_01_08_423993	699	29	for	for	IN
10_1101-2021_01_08_423993	699	30	Zinc	Zinc	NNP
10_1101-2021_01_08_423993	699	31	Ejector	Ejector	NNP
10_1101-2021_01_08_423993	699	32	Drugs	drug	NNS
10_1101-2021_01_08_423993	699	33	.	.	.
10_1101-2021_01_08_423993	700	1	91	91	CD
10_1101-2021_01_08_423993	700	2	,	,	,
10_1101-2021_01_08_423993	700	3	1–20	1–20	CD
10_1101-2021_01_08_423993	700	4	.	.	.
10_1101-2021_01_08_423993	701	1	71	71	CD
10_1101-2021_01_08_423993	701	2	.	.	.
10_1101-2021_01_08_423993	702	1	Brandt	Brandt	NNP
10_1101-2021_01_08_423993	702	2	VL	VL	NNP
10_1101-2021_01_08_423993	702	3	&	&	CC
10_1101-2021_01_08_423993	702	4	Roth	Roth	NNP
10_1101-2021_01_08_423993	702	5	DB	DB	NNP
10_1101-2021_01_08_423993	702	6	(	(	-LRB-
10_1101-2021_01_08_423993	702	7	2003	2003	CD
10_1101-2021_01_08_423993	702	8	)	)	-RRB-
10_1101-2021_01_08_423993	702	9	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	702	10	:	:	:
10_1101-2021_01_08_423993	702	11	Guarding	guard	VBG
10_1101-2021_01_08_423993	702	12	small	small	JJ
10_1101-2021_01_08_423993	702	13	children	child	NNS
10_1101-2021_01_08_423993	702	14	and	and	CC
10_1101-2021_01_08_423993	702	15	,	,	,
10_1101-2021_01_08_423993	702	16	now	now	RB
10_1101-2021_01_08_423993	702	17	,	,	,
10_1101-2021_01_08_423993	702	18	the	the	DT
10_1101-2021_01_08_423993	702	19	genome	genome	JJ
10_1101-2021_01_08_423993	702	20	.	.	.
10_1101-2021_01_08_423993	703	1	J.	J.	NNP
10_1101-2021_01_08_423993	703	2	Clin	Clin	NNP
10_1101-2021_01_08_423993	703	3	.	.	.
10_1101-2021_01_08_423993	704	1	Invest	invest	VB
10_1101-2021_01_08_423993	704	2	.	.	.
10_1101-2021_01_08_423993	705	1	111	111	CD
10_1101-2021_01_08_423993	705	2	,	,	,
10_1101-2021_01_08_423993	705	3	315–316	315–316	CD
10_1101-2021_01_08_423993	705	4	.	.	.
10_1101-2021_01_08_423993	706	1	72	72	CD
10_1101-2021_01_08_423993	706	2	.	.	.
10_1101-2021_01_08_423993	707	1	Vázquez	Vázquez	NNP
10_1101-2021_01_08_423993	707	2	-	-	HYPH
10_1101-2021_01_08_423993	707	3	Torres	Torres	NNP
10_1101-2021_01_08_423993	707	4	A	a	NN
10_1101-2021_01_08_423993	707	5	(	(	-LRB-
10_1101-2021_01_08_423993	707	6	2012	2012	CD
10_1101-2021_01_08_423993	707	7	)	)	-RRB-
10_1101-2021_01_08_423993	707	8	Redox	redox	NN
10_1101-2021_01_08_423993	707	9	active	active	JJ
10_1101-2021_01_08_423993	707	10	thiol	thiol	NN
10_1101-2021_01_08_423993	707	11	sensors	sensor	NNS
10_1101-2021_01_08_423993	707	12	of	of	IN
10_1101-2021_01_08_423993	707	13	oxidative	oxidative	JJ
10_1101-2021_01_08_423993	707	14	and	and	CC
10_1101-2021_01_08_423993	707	15	nitrosative	nitrosative	JJ
10_1101-2021_01_08_423993	707	16	stress	stress	NN
10_1101-2021_01_08_423993	707	17	.	.	.
10_1101-2021_01_08_423993	708	1	Antioxidants	Antioxidants	NNPS
10_1101-2021_01_08_423993	708	2	Redox	Redox	NNP
10_1101-2021_01_08_423993	708	3	Signal	Signal	NNP
10_1101-2021_01_08_423993	708	4	.	.	.
10_1101-2021_01_08_423993	709	1	17	17	CD
10_1101-2021_01_08_423993	709	2	,	,	,
10_1101-2021_01_08_423993	709	3	1201–1214	1201–1214	CD
10_1101-2021_01_08_423993	709	4	.	.	.
10_1101-2021_01_08_423993	710	1	73	73	CD
10_1101-2021_01_08_423993	710	2	.	.	.
10_1101-2021_01_08_423993	711	1	Mao	Mao	NNP
10_1101-2021_01_08_423993	711	2	Z	Z	NNP
10_1101-2021_01_08_423993	711	3	,	,	,
10_1101-2021_01_08_423993	711	4	Bozzella	Bozzella	NNP
10_1101-2021_01_08_423993	711	5	M	M	NNP
10_1101-2021_01_08_423993	711	6	,	,	,
10_1101-2021_01_08_423993	711	7	Seluanov	Seluanov	NNP
10_1101-2021_01_08_423993	711	8	A	A	NNP
10_1101-2021_01_08_423993	711	9	&	&	CC
10_1101-2021_01_08_423993	711	10	Gorbunova	Gorbunova	NNP
10_1101-2021_01_08_423993	711	11	V	V	NNP
10_1101-2021_01_08_423993	711	12	(	(	-LRB-
10_1101-2021_01_08_423993	711	13	2008	2008	CD
10_1101-2021_01_08_423993	711	14	)	)	-RRB-
10_1101-2021_01_08_423993	711	15	Comparison	comparison	NN
10_1101-2021_01_08_423993	711	16	of	of	IN
10_1101-2021_01_08_423993	711	17	nonhomologous	nonhomologous	JJ
10_1101-2021_01_08_423993	711	18	end	end	NN
10_1101-2021_01_08_423993	711	19	joining	joining	NN
10_1101-2021_01_08_423993	711	20	and	and	CC
10_1101-2021_01_08_423993	711	21	homologous	homologous	JJ
10_1101-2021_01_08_423993	711	22	recombination	recombination	NN
10_1101-2021_01_08_423993	711	23	in	in	IN
10_1101-2021_01_08_423993	711	24	human	human	JJ
10_1101-2021_01_08_423993	711	25	cells	cell	NNS
10_1101-2021_01_08_423993	711	26	.	.	.
10_1101-2021_01_08_423993	712	1	DNA	DNA	NNP
10_1101-2021_01_08_423993	712	2	Repair	Repair	NNP
10_1101-2021_01_08_423993	712	3	(	(	-LRB-
10_1101-2021_01_08_423993	712	4	Amst	Amst	NNP
10_1101-2021_01_08_423993	712	5	)	)	-RRB-
10_1101-2021_01_08_423993	712	6	.	.	.
10_1101-2021_01_08_423993	713	1	7	7	CD
10_1101-2021_01_08_423993	713	2	,	,	,
10_1101-2021_01_08_423993	713	3	1765	1765	CD
10_1101-2021_01_08_423993	713	4	–	–	:
10_1101-2021_01_08_423993	713	5	1771	1771	CD
10_1101-2021_01_08_423993	713	6	.	.	.
10_1101-2021_01_08_423993	714	1	74	74	CD
10_1101-2021_01_08_423993	714	2	.	.	.
10_1101-2021_01_08_423993	715	1	Pettinati	Pettinati	NNP
10_1101-2021_01_08_423993	715	2	I	-PRON-	PRP
10_1101-2021_01_08_423993	715	3	,	,	,
10_1101-2021_01_08_423993	715	4	Brem	Brem	NNP
10_1101-2021_01_08_423993	715	5	J	J	NNP
10_1101-2021_01_08_423993	715	6	,	,	,
10_1101-2021_01_08_423993	715	7	Lee	Lee	NNP
10_1101-2021_01_08_423993	715	8	SY	SY	NNP
10_1101-2021_01_08_423993	715	9	,	,	,
10_1101-2021_01_08_423993	715	10	Mchugh	Mchugh	NNP
10_1101-2021_01_08_423993	715	11	PJ	PJ	NNP
10_1101-2021_01_08_423993	715	12	&	&	CC
10_1101-2021_01_08_423993	715	13	Scho	Scho	NNP
10_1101-2021_01_08_423993	715	14	CJ	CJ	NNP
10_1101-2021_01_08_423993	715	15	(	(	-LRB-
10_1101-2021_01_08_423993	715	16	2016	2016	CD
10_1101-2021_01_08_423993	715	17	)	)	-RRB-
10_1101-2021_01_08_423993	715	18	The	the	DT
10_1101-2021_01_08_423993	715	19	Chemical	Chemical	NNP
10_1101-2021_01_08_423993	715	20	Biology	Biology	NNP
10_1101-2021_01_08_423993	715	21	of	of	IN
10_1101-2021_01_08_423993	715	22	Human	Human	NNP
10_1101-2021_01_08_423993	715	23	Metallo-	Metallo-	NNP
10_1101-2021_01_08_423993	715	24	b	b	NNP
10_1101-2021_01_08_423993	715	25	-Lactamase	-Lactamase	:
10_1101-2021_01_08_423993	715	26	Fold	Fold	NNP
10_1101-2021_01_08_423993	715	27	Proteins	Proteins	NNP
10_1101-2021_01_08_423993	715	28	.	.	.
10_1101-2021_01_08_423993	716	1	Trends	Trends	NNPS
10_1101-2021_01_08_423993	716	2	Biochem	Biochem	NNP
10_1101-2021_01_08_423993	716	3	.	.	.
10_1101-2021_01_08_423993	717	1	Sci	Sci	NNP
10_1101-2021_01_08_423993	717	2	.	.	.
10_1101-2021_01_08_423993	718	1	41	41	CD
10_1101-2021_01_08_423993	718	2	,	,	,
10_1101-2021_01_08_423993	718	3	338–355	338–355	CD
10_1101-2021_01_08_423993	718	4	.	.	.
10_1101-2021_01_08_423993	719	1	75	75	CD
10_1101-2021_01_08_423993	719	2	.	.	.
10_1101-2021_01_08_423993	720	1	Cahill	Cahill	NNP
10_1101-2021_01_08_423993	720	2	ST	ST	NNP
10_1101-2021_01_08_423993	720	3	,	,	,
10_1101-2021_01_08_423993	720	4	Tarhonskaya	Tarhonskaya	NNP
10_1101-2021_01_08_423993	720	5	H	H	NNP
10_1101-2021_01_08_423993	720	6	,	,	,
10_1101-2021_01_08_423993	720	7	Rydzik	Rydzik	NNP
10_1101-2021_01_08_423993	720	8	AM	AM	NNP
10_1101-2021_01_08_423993	720	9	,	,	,
10_1101-2021_01_08_423993	720	10	Flashman	Flashman	NNP
10_1101-2021_01_08_423993	720	11	E	E	NNP
10_1101-2021_01_08_423993	720	12	,	,	,
10_1101-2021_01_08_423993	720	13	McDonough	McDonough	NNP
10_1101-2021_01_08_423993	720	14	MA	MA	NNP
10_1101-2021_01_08_423993	720	15	,	,	,
10_1101-2021_01_08_423993	720	16	Schofield	Schofield	NNP
10_1101-2021_01_08_423993	720	17	CJ	CJ	NNP
10_1101-2021_01_08_423993	720	18	&	&	CC
10_1101-2021_01_08_423993	720	19	Brem	Brem	NNP
10_1101-2021_01_08_423993	720	20	J	J	NNP
10_1101-2021_01_08_423993	720	21	(	(	-LRB-
10_1101-2021_01_08_423993	720	22	2016	2016	CD
10_1101-2021_01_08_423993	720	23	)	)	-RRB-
10_1101-2021_01_08_423993	720	24	Use	Use	NNP
10_1101-2021_01_08_423993	720	25	of	of	IN
10_1101-2021_01_08_423993	720	26	ferrous	ferrous	JJ
10_1101-2021_01_08_423993	720	27	iron	iron	NN
10_1101-2021_01_08_423993	720	28	by	by	IN
10_1101-2021_01_08_423993	720	29	metallo	metallo	NN
10_1101-2021_01_08_423993	720	30	-	-	HYPH
10_1101-2021_01_08_423993	720	31	β	β	NN
10_1101-2021_01_08_423993	720	32	-	-	HYPH
10_1101-2021_01_08_423993	720	33	lactamases	lactamase	NNS
10_1101-2021_01_08_423993	720	34	.	.	.
10_1101-2021_01_08_423993	721	1	J.	J.	NNP
10_1101-2021_01_08_423993	721	2	Inorg	Inorg	NNP
10_1101-2021_01_08_423993	721	3	.	.	.
10_1101-2021_01_08_423993	722	1	Biochem	Biochem	NNP
10_1101-2021_01_08_423993	722	2	.	.	.
10_1101-2021_01_08_423993	723	1	163	163	CD
10_1101-2021_01_08_423993	723	2	,	,	,
10_1101-2021_01_08_423993	723	3	185–193	185–193	CD
10_1101-2021_01_08_423993	723	4	.	.	.
10_1101-2021_01_08_423993	724	1	76	76	CD
10_1101-2021_01_08_423993	724	2	.	.	.
10_1101-2021_01_08_423993	725	1	Newman	Newman	NNP
10_1101-2021_01_08_423993	725	2	JA	JA	NNP
10_1101-2021_01_08_423993	725	3	,	,	,
10_1101-2021_01_08_423993	725	4	Hewitt	Hewitt	NNP
10_1101-2021_01_08_423993	725	5	L	L	NNP
10_1101-2021_01_08_423993	725	6	,	,	,
10_1101-2021_01_08_423993	725	7	Rodrigues	Rodrigues	NNP
10_1101-2021_01_08_423993	725	8	C	C	NNP
10_1101-2021_01_08_423993	725	9	,	,	,
10_1101-2021_01_08_423993	725	10	Solovyova	Solovyova	NNP
10_1101-2021_01_08_423993	725	11	A	A	NNP
10_1101-2021_01_08_423993	725	12	,	,	,
10_1101-2021_01_08_423993	725	13	Harwood	Harwood	NNP
10_1101-2021_01_08_423993	725	14	CR	CR	NNP
10_1101-2021_01_08_423993	725	15	&	&	CC
10_1101-2021_01_08_423993	725	16	Lewis	Lewis	NNP
10_1101-2021_01_08_423993	725	17	RJ	RJ	NNP
10_1101-2021_01_08_423993	725	18	(	(	-LRB-
10_1101-2021_01_08_423993	725	19	2011	2011	CD
10_1101-2021_01_08_423993	725	20	)	)	-RRB-
10_1101-2021_01_08_423993	725	21	Unusual	unusual	JJ
10_1101-2021_01_08_423993	725	22	,	,	,
10_1101-2021_01_08_423993	725	23	dual	dual	JJ
10_1101-2021_01_08_423993	725	24	endo-	endo-	NN
10_1101-2021_01_08_423993	725	25	and	and	CC
10_1101-2021_01_08_423993	725	26	exonuclease	exonuclease	NN
10_1101-2021_01_08_423993	725	27	activity	activity	NN
10_1101-2021_01_08_423993	725	28	in	in	IN
10_1101-2021_01_08_423993	725	29	the	the	DT
10_1101-2021_01_08_423993	725	30	degradosome	degradosome	NN
10_1101-2021_01_08_423993	725	31	explained	explain	VBN
10_1101-2021_01_08_423993	725	32	by	by	IN
10_1101-2021_01_08_423993	725	33	crystal	crystal	NN
10_1101-2021_01_08_423993	725	34	structure	structure	NN
10_1101-2021_01_08_423993	725	35	analysis	analysis	NN
10_1101-2021_01_08_423993	725	36	of	of	IN
10_1101-2021_01_08_423993	725	37	RNase	RNase	NNP
10_1101-2021_01_08_423993	725	38	J1	J1	NNP
10_1101-2021_01_08_423993	725	39	.	.	.
10_1101-2021_01_08_423993	726	1	Structure	structure	NN
10_1101-2021_01_08_423993	726	2	19	19	CD
10_1101-2021_01_08_423993	726	3	,	,	,
10_1101-2021_01_08_423993	726	4	1241–1251	1241–1251	CD
10_1101-2021_01_08_423993	726	5	.	.	.
10_1101-2021_01_08_423993	727	1	77	77	CD
10_1101-2021_01_08_423993	727	2	.	.	.
10_1101-2021_01_08_423993	728	1	Raj	Raj	NNP
10_1101-2021_01_08_423993	728	2	R	R	NNP
10_1101-2021_01_08_423993	728	3	,	,	,
10_1101-2021_01_08_423993	728	4	Nadig	Nadig	NNP
10_1101-2021_01_08_423993	728	5	S	S	NNP
10_1101-2021_01_08_423993	728	6	,	,	,
10_1101-2021_01_08_423993	728	7	Patel	Patel	NNP
10_1101-2021_01_08_423993	728	8	T	T	NNP
10_1101-2021_01_08_423993	728	9	&	&	CC
10_1101-2021_01_08_423993	728	10	Gopal	Gopal	NNP
10_1101-2021_01_08_423993	728	11	B	B	NNP
10_1101-2021_01_08_423993	728	12	(	(	-LRB-
10_1101-2021_01_08_423993	728	13	2020	2020	CD
10_1101-2021_01_08_423993	728	14	)	)	-RRB-
10_1101-2021_01_08_423993	728	15	Structural	structural	JJ
10_1101-2021_01_08_423993	728	16	and	and	CC
10_1101-2021_01_08_423993	728	17	biochemical	biochemical	JJ
10_1101-2021_01_08_423993	728	18	characteristics	characteristic	NNS
10_1101-2021_01_08_423993	728	19	of	of	IN
10_1101-2021_01_08_423993	728	20	two	two	CD
10_1101-2021_01_08_423993	728	21	Staphylococcus	Staphylococcus	NNP
10_1101-2021_01_08_423993	728	22	epidermidis	epidermidis	NN
10_1101-2021_01_08_423993	728	23	RNase	RNase	NNP
10_1101-2021_01_08_423993	728	24	J	J	NNP
10_1101-2021_01_08_423993	728	25	paralogues	paralogue	NNS
10_1101-2021_01_08_423993	728	26	RNase	rnase	UH
10_1101-2021_01_08_423993	728	27	J1	J1	NNP
10_1101-2021_01_08_423993	728	28	and	and	CC
10_1101-2021_01_08_423993	728	29	RNase	RNase	NNP
10_1101-2021_01_08_423993	728	30	J2	J2	NNP
10_1101-2021_01_08_423993	728	31	.	.	.
10_1101-2021_01_08_423993	729	1	J.	J.	NNP
10_1101-2021_01_08_423993	729	2	Biol	Biol	NNP
10_1101-2021_01_08_423993	729	3	.	.	.
10_1101-2021_01_08_423993	730	1	Chem	Chem	NNP
10_1101-2021_01_08_423993	730	2	.	.	NNP
10_1101-2021_01_08_423993	730	3	,	,	,
10_1101-2021_01_08_423993	730	4	jbc	jbc	NNP
10_1101-2021_01_08_423993	730	5	.	.	.
10_1101-2021_01_08_423993	730	6	RA120.014876	RA120.014876	NNP
10_1101-2021_01_08_423993	730	7	.	.	.
10_1101-2021_01_08_423993	731	1	78	78	CD
10_1101-2021_01_08_423993	731	2	.	.	.
10_1101-2021_01_08_423993	732	1	Hamed	ham	VBN
10_1101-2021_01_08_423993	732	2	RB	RB	NNP
10_1101-2021_01_08_423993	732	3	,	,	,
10_1101-2021_01_08_423993	732	4	Gomez	Gomez	NNP
10_1101-2021_01_08_423993	732	5	-	-	HYPH
10_1101-2021_01_08_423993	732	6	Castellanos	Castellanos	NNP
10_1101-2021_01_08_423993	732	7	R	R	NNP
10_1101-2021_01_08_423993	732	8	,	,	,
10_1101-2021_01_08_423993	732	9	Henry	Henry	NNP
10_1101-2021_01_08_423993	732	10	L	L	NNP
10_1101-2021_01_08_423993	732	11	,	,	,
10_1101-2021_01_08_423993	732	12	Ducho	Ducho	NNP
10_1101-2021_01_08_423993	732	13	C	C	NNP
10_1101-2021_01_08_423993	732	14	,	,	,
10_1101-2021_01_08_423993	732	15	Mcdonough	Mcdonough	NNP
10_1101-2021_01_08_423993	732	16	MA	MA	NNP
10_1101-2021_01_08_423993	732	17	&	&	CC
10_1101-2021_01_08_423993	732	18	Schofield	Schofield	NNP
10_1101-2021_01_08_423993	732	19	CJ	CJ	NNP
10_1101-2021_01_08_423993	732	20	(	(	-LRB-
10_1101-2021_01_08_423993	732	21	2013	2013	CD
10_1101-2021_01_08_423993	732	22	)	)	-RRB-
10_1101-2021_01_08_423993	732	23	The	the	DT
10_1101-2021_01_08_423993	732	24	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	732	25	of	of	IN
10_1101-2021_01_08_423993	732	26	B	b	NN
10_1101-2021_01_08_423993	732	27	-	-	HYPH
10_1101-2021_01_08_423993	732	28	lactam	lactam	NNP
10_1101-2021_01_08_423993	732	29	biosynthesis	biosynthesis	NN
10_1101-2021_01_08_423993	732	30	.	.	.
10_1101-2021_01_08_423993	733	1	Nat	Nat	NNP
10_1101-2021_01_08_423993	733	2	.	.	.
10_1101-2021_01_08_423993	734	1	Prod	Prod	NNP
10_1101-2021_01_08_423993	734	2	.	.	.
10_1101-2021_01_08_423993	735	1	Rep.	Rep.	NNP
10_1101-2021_01_08_423993	735	2	30	30	CD
10_1101-2021_01_08_423993	735	3	,	,	,
10_1101-2021_01_08_423993	735	4	1–204	1–204	CD
10_1101-2021_01_08_423993	735	5	.	.	.
10_1101-2021_01_08_423993	736	1	79	79	CD
10_1101-2021_01_08_423993	736	2	.	.	.
10_1101-2021_01_08_423993	737	1	Antony	Antony	NNP
10_1101-2021_01_08_423993	737	2	S	S	NNP
10_1101-2021_01_08_423993	737	3	&	&	CC
10_1101-2021_01_08_423993	737	4	Bayse	Bayse	NNP
10_1101-2021_01_08_423993	737	5	CA	CA	NNP
10_1101-2021_01_08_423993	737	6	(	(	-LRB-
10_1101-2021_01_08_423993	737	7	2013	2013	CD
10_1101-2021_01_08_423993	737	8	)	)	-RRB-
10_1101-2021_01_08_423993	737	9	Density	Density	NNP
10_1101-2021_01_08_423993	737	10	Functional	Functional	NNP
10_1101-2021_01_08_423993	737	11	Theory	Theory	NNP
10_1101-2021_01_08_423993	737	12	Study	Study	NNP
10_1101-2021_01_08_423993	737	13	of	of	IN
10_1101-2021_01_08_423993	737	14	the	the	DT
10_1101-2021_01_08_423993	737	15	Attack	Attack	NNP
10_1101-2021_01_08_423993	737	16	of	of	IN
10_1101-2021_01_08_423993	737	17	Ebselen	Ebselen	NNP
10_1101-2021_01_08_423993	737	18	on	on	IN
10_1101-2021_01_08_423993	737	19	a	a	DT
10_1101-2021_01_08_423993	737	20	Zinc-	Zinc-	NNP
10_1101-2021_01_08_423993	737	21	Finger	Finger	NNP
10_1101-2021_01_08_423993	737	22	Model	Model	NNP
10_1101-2021_01_08_423993	737	23	.	.	.
10_1101-2021_01_08_423993	738	1	Inorg	Inorg	NNP
10_1101-2021_01_08_423993	738	2	.	.	.
10_1101-2021_01_08_423993	739	1	Chem	Chem	NNP
10_1101-2021_01_08_423993	739	2	.	.	.
10_1101-2021_01_08_423993	740	1	52	52	CD
10_1101-2021_01_08_423993	740	2	,	,	,
10_1101-2021_01_08_423993	740	3	13803–13805	13803–13805	CD
10_1101-2021_01_08_423993	740	4	.	.	.
10_1101-2021_01_08_423993	741	1	80	80	CD
10_1101-2021_01_08_423993	741	2	.	.	.
10_1101-2021_01_08_423993	742	1	Lee	Lee	NNP
10_1101-2021_01_08_423993	742	2	Y	Y	NNP
10_1101-2021_01_08_423993	742	3	,	,	,
10_1101-2021_01_08_423993	742	4	Wang	Wang	NNP
10_1101-2021_01_08_423993	742	5	Y	Y	NNP
10_1101-2021_01_08_423993	742	6	,	,	,
10_1101-2021_01_08_423993	742	7	Duh	Duh	NNP
10_1101-2021_01_08_423993	742	8	Y	Y	NNP
10_1101-2021_01_08_423993	742	9	,	,	,
10_1101-2021_01_08_423993	742	10	Yuan	Yuan	NNP
10_1101-2021_01_08_423993	742	11	HS	HS	NNP
10_1101-2021_01_08_423993	742	12	&	&	CC
10_1101-2021_01_08_423993	742	13	Lim	Lim	NNP
10_1101-2021_01_08_423993	742	14	C	C	NNP
10_1101-2021_01_08_423993	742	15	(	(	-LRB-
10_1101-2021_01_08_423993	742	16	2013	2013	CD
10_1101-2021_01_08_423993	742	17	)	)	-RRB-
10_1101-2021_01_08_423993	742	18	Identification	identification	NN
10_1101-2021_01_08_423993	742	19	of	of	IN
10_1101-2021_01_08_423993	742	20	Labile	Labile	NNP
10_1101-2021_01_08_423993	742	21	Zn	Zn	NNP
10_1101-2021_01_08_423993	742	22	Sites	Sites	NNPS
10_1101-2021_01_08_423993	742	23	in	in	IN
10_1101-2021_01_08_423993	742	24	Drug-	Drug-	NNP
10_1101-2021_01_08_423993	742	25	Target	Target	NNP
10_1101-2021_01_08_423993	742	26	Proteins	Proteins	NNP
10_1101-2021_01_08_423993	742	27	.	.	.
10_1101-2021_01_08_423993	743	1	J.	J.	NNP
10_1101-2021_01_08_423993	744	1	Am	Am	NNP
10_1101-2021_01_08_423993	744	2	.	.	.
10_1101-2021_01_08_423993	745	1	Chem	Chem	NNP
10_1101-2021_01_08_423993	745	2	.	.	.
10_1101-2021_01_08_423993	746	1	Soc	Soc	NNP
10_1101-2021_01_08_423993	746	2	.	.	.
10_1101-2021_01_08_423993	747	1	135	135	CD
10_1101-2021_01_08_423993	747	2	,	,	,
10_1101-2021_01_08_423993	747	3	14028–14031	14028–14031	CD
10_1101-2021_01_08_423993	747	4	.	.	.
10_1101-2021_01_08_423993	748	1	81	81	CD
10_1101-2021_01_08_423993	748	2	.	.	.
10_1101-2021_01_08_423993	749	1	May	May	NNP
10_1101-2021_01_08_423993	749	2	HC	HC	NNP
10_1101-2021_01_08_423993	749	3	,	,	,
10_1101-2021_01_08_423993	749	4	Yu	Yu	NNP
10_1101-2021_01_08_423993	749	5	JJ	JJ	NNP
10_1101-2021_01_08_423993	749	6	,	,	,
10_1101-2021_01_08_423993	749	7	N.	N.	NNP
10_1101-2021_01_08_423993	749	8	Guentzel	Guentzel	NNP
10_1101-2021_01_08_423993	749	9	M	M	NNP
10_1101-2021_01_08_423993	749	10	,	,	,
10_1101-2021_01_08_423993	749	11	Chambers	Chambers	NNP
10_1101-2021_01_08_423993	749	12	JP	JP	NNP
10_1101-2021_01_08_423993	749	13	,	,	,
10_1101-2021_01_08_423993	749	14	Cap	Cap	NNP
10_1101-2021_01_08_423993	749	15	AP	AP	NNP
10_1101-2021_01_08_423993	749	16	&	&	CC
10_1101-2021_01_08_423993	749	17	Arulanandam	Arulanandam	NNP
10_1101-2021_01_08_423993	749	18	BP	BP	NNP
10_1101-2021_01_08_423993	749	19	(	(	-LRB-
10_1101-2021_01_08_423993	749	20	2018	2018	CD
10_1101-2021_01_08_423993	749	21	)	)	-RRB-
10_1101-2021_01_08_423993	749	22	Repurposing	repurpose	VBG
10_1101-2021_01_08_423993	749	23	auranofin	auranofin	NN
10_1101-2021_01_08_423993	749	24	,	,	,
10_1101-2021_01_08_423993	749	25	ebselen	ebselen	VBD
10_1101-2021_01_08_423993	749	26	,	,	,
10_1101-2021_01_08_423993	749	27	and	and	CC
10_1101-2021_01_08_423993	749	28	PX-12	PX-12	NNP
10_1101-2021_01_08_423993	749	29	as	as	IN
10_1101-2021_01_08_423993	749	30	antimicrobial	antimicrobial	JJ
10_1101-2021_01_08_423993	749	31	agents	agent	NNS
10_1101-2021_01_08_423993	749	32	targeting	target	VBG
10_1101-2021_01_08_423993	749	33	the	the	DT
10_1101-2021_01_08_423993	749	34	thioredoxin	thioredoxin	NN
10_1101-2021_01_08_423993	749	35	system	system	NN
10_1101-2021_01_08_423993	749	36	.	.	.
10_1101-2021_01_08_423993	750	1	Front	front	NN
10_1101-2021_01_08_423993	750	2	.	.	.
10_1101-2021_01_08_423993	751	1	Microbiol	Microbiol	NNP
10_1101-2021_01_08_423993	751	2	.	.	.
10_1101-2021_01_08_423993	752	1	9	9	CD
10_1101-2021_01_08_423993	752	2	,	,	,
10_1101-2021_01_08_423993	752	3	1–10	1–10	CD
10_1101-2021_01_08_423993	752	4	.	.	.
10_1101-2021_01_08_423993	753	1	82	82	CD
10_1101-2021_01_08_423993	753	2	.	.	.
10_1101-2021_01_08_423993	754	1	Noguchi	Noguchi	NNP
10_1101-2021_01_08_423993	754	2	N	N	NNP
10_1101-2021_01_08_423993	754	3	(	(	-LRB-
10_1101-2021_01_08_423993	754	4	2016	2016	CD
10_1101-2021_01_08_423993	754	5	)	)	-RRB-
10_1101-2021_01_08_423993	754	6	Ebselen	Ebselen	NNP
10_1101-2021_01_08_423993	754	7	,	,	,
10_1101-2021_01_08_423993	754	8	a	a	DT
10_1101-2021_01_08_423993	754	9	useful	useful	JJ
10_1101-2021_01_08_423993	754	10	tool	tool	NN
10_1101-2021_01_08_423993	754	11	for	for	IN
10_1101-2021_01_08_423993	754	12	understanding	understand	VBG
10_1101-2021_01_08_423993	754	13	cellular	cellular	JJ
10_1101-2021_01_08_423993	754	14	redox	redox	NN
10_1101-2021_01_08_423993	754	15	biology	biology	NN
10_1101-2021_01_08_423993	754	16	and	and	CC
10_1101-2021_01_08_423993	754	17	a	a	DT
10_1101-2021_01_08_423993	754	18	promising	promising	JJ
10_1101-2021_01_08_423993	754	19	drug	drug	NN
10_1101-2021_01_08_423993	754	20	candidate	candidate	NN
10_1101-2021_01_08_423993	754	21	for	for	IN
10_1101-2021_01_08_423993	754	22	use	use	NN
10_1101-2021_01_08_423993	754	23	in	in	IN
10_1101-2021_01_08_423993	754	24	human	human	JJ
10_1101-2021_01_08_423993	754	25	diseases	disease	NNS
10_1101-2021_01_08_423993	754	26	.	.	.
10_1101-2021_01_08_423993	755	1	Arch	arch	UH
10_1101-2021_01_08_423993	755	2	.	.	.
10_1101-2021_01_08_423993	756	1	Biochem	Biochem	NNP
10_1101-2021_01_08_423993	756	2	.	.	.
10_1101-2021_01_08_423993	757	1	Biophys	Biophys	NNP
10_1101-2021_01_08_423993	757	2	.	.	.
10_1101-2021_01_08_423993	758	1	595	595	CD
10_1101-2021_01_08_423993	758	2	,	,	,
10_1101-2021_01_08_423993	758	3	109	109	CD
10_1101-2021_01_08_423993	758	4	–	–	:
10_1101-2021_01_08_423993	758	5	112	112	CD
10_1101-2021_01_08_423993	758	6	.	.	.
10_1101-2021_01_08_423993	759	1	83	83	CD
10_1101-2021_01_08_423993	759	2	.	.	.
10_1101-2021_01_08_423993	760	1	Roder	Roder	NNP
10_1101-2021_01_08_423993	760	2	C	C	NNP
10_1101-2021_01_08_423993	760	3	&	&	CC
10_1101-2021_01_08_423993	760	4	Thomson	Thomson	NNP
10_1101-2021_01_08_423993	760	5	MJ	MJ	NNP
10_1101-2021_01_08_423993	760	6	(	(	-LRB-
10_1101-2021_01_08_423993	760	7	2015	2015	CD
10_1101-2021_01_08_423993	760	8	)	)	-RRB-
10_1101-2021_01_08_423993	760	9	Auranofin	Auranofin	NNP
10_1101-2021_01_08_423993	760	10	:	:	:
10_1101-2021_01_08_423993	760	11	Repurposing	repurpose	VBG
10_1101-2021_01_08_423993	760	12	an	an	DT
10_1101-2021_01_08_423993	760	13	Old	Old	NNP
10_1101-2021_01_08_423993	760	14	Drug	Drug	NNP
10_1101-2021_01_08_423993	760	15	for	for	IN
10_1101-2021_01_08_423993	760	16	a	a	DT
10_1101-2021_01_08_423993	760	17	Golden	Golden	NNP
10_1101-2021_01_08_423993	760	18	New	New	NNP
10_1101-2021_01_08_423993	760	19	Age	Age	NNP
10_1101-2021_01_08_423993	760	20	.	.	.
10_1101-2021_01_08_423993	761	1	Drugs	drug	NNS
10_1101-2021_01_08_423993	761	2	R	r	NN
10_1101-2021_01_08_423993	761	3	D	d	NN
10_1101-2021_01_08_423993	761	4	15	15	CD
10_1101-2021_01_08_423993	761	5	,	,	,
10_1101-2021_01_08_423993	761	6	13–20	13–20	CD
10_1101-2021_01_08_423993	761	7	.	.	.
10_1101-2021_01_08_423993	762	1	84	84	CD
10_1101-2021_01_08_423993	762	2	.	.	.
10_1101-2021_01_08_423993	763	1	Jin	Jin	NNP
10_1101-2021_01_08_423993	763	2	Z	Z	NNP
10_1101-2021_01_08_423993	763	3	,	,	,
10_1101-2021_01_08_423993	763	4	Du	Du	NNP
10_1101-2021_01_08_423993	763	5	X	X	NNP
10_1101-2021_01_08_423993	763	6	,	,	,
10_1101-2021_01_08_423993	763	7	Xu	Xu	NNP
10_1101-2021_01_08_423993	763	8	Y	Y	NNP
10_1101-2021_01_08_423993	763	9	,	,	,
10_1101-2021_01_08_423993	763	10	Deng	Deng	NNP
10_1101-2021_01_08_423993	763	11	Y	Y	NNP
10_1101-2021_01_08_423993	763	12	,	,	,
10_1101-2021_01_08_423993	763	13	Liu	Liu	NNP
10_1101-2021_01_08_423993	763	14	M	M	NNP
10_1101-2021_01_08_423993	763	15	,	,	,
10_1101-2021_01_08_423993	763	16	Zhao	Zhao	NNP
10_1101-2021_01_08_423993	763	17	Y	Y	NNP
10_1101-2021_01_08_423993	763	18	,	,	,
10_1101-2021_01_08_423993	763	19	Zhang	Zhang	NNP
10_1101-2021_01_08_423993	763	20	B	B	NNP
10_1101-2021_01_08_423993	763	21	,	,	,
10_1101-2021_01_08_423993	763	22	Li	Li	NNP
10_1101-2021_01_08_423993	763	23	X	X	NNP
10_1101-2021_01_08_423993	763	24	,	,	,
10_1101-2021_01_08_423993	763	25	Zhang	Zhang	NNP
10_1101-2021_01_08_423993	763	26	L	L	NNP
10_1101-2021_01_08_423993	763	27	,	,	,
10_1101-2021_01_08_423993	763	28	Peng	Peng	NNP
10_1101-2021_01_08_423993	763	29	C	C	NNP
10_1101-2021_01_08_423993	763	30	,	,	,
10_1101-2021_01_08_423993	763	31	Duan	Duan	NNP
10_1101-2021_01_08_423993	763	32	Y	Y	NNP
10_1101-2021_01_08_423993	763	33	,	,	,
10_1101-2021_01_08_423993	763	34	Yu	Yu	NNP
10_1101-2021_01_08_423993	763	35	J	J	NNP
10_1101-2021_01_08_423993	763	36	,	,	,
10_1101-2021_01_08_423993	763	37	Wang	Wang	NNP
10_1101-2021_01_08_423993	763	38	L	L	NNP
10_1101-2021_01_08_423993	763	39	,	,	,
10_1101-2021_01_08_423993	763	40	Yang	Yang	NNP
10_1101-2021_01_08_423993	763	41	K	K	NNP
10_1101-2021_01_08_423993	763	42	,	,	,
10_1101-2021_01_08_423993	763	43	Liu	Liu	NNP
10_1101-2021_01_08_423993	763	44	F	F	NNP
10_1101-2021_01_08_423993	763	45	,	,	,
10_1101-2021_01_08_423993	763	46	Jiang	Jiang	NNP
10_1101-2021_01_08_423993	763	47	R	R	NNP
10_1101-2021_01_08_423993	763	48	,	,	,
10_1101-2021_01_08_423993	763	49	Yang	Yang	NNP
10_1101-2021_01_08_423993	763	50	X	X	NNP
10_1101-2021_01_08_423993	763	51	,	,	,
10_1101-2021_01_08_423993	763	52	You	-PRON-	PRP
10_1101-2021_01_08_423993	763	53	T	T	NNP
10_1101-2021_01_08_423993	763	54	,	,	,
10_1101-2021_01_08_423993	763	55	Liu	Liu	NNP
10_1101-2021_01_08_423993	763	56	X	X	NNP
10_1101-2021_01_08_423993	763	57	,	,	,
10_1101-2021_01_08_423993	763	58	Yang	Yang	NNP
10_1101-2021_01_08_423993	763	59	X	X	NNP
10_1101-2021_01_08_423993	763	60	,	,	,
10_1101-2021_01_08_423993	763	61	Bai	Bai	NNP
10_1101-2021_01_08_423993	763	62	F	F	NNP
10_1101-2021_01_08_423993	763	63	,	,	,
10_1101-2021_01_08_423993	763	64	Liu	Liu	NNP
10_1101-2021_01_08_423993	763	65	H	H	NNP
10_1101-2021_01_08_423993	763	66	,	,	,
10_1101-2021_01_08_423993	763	67	Liu	Liu	NNP
10_1101-2021_01_08_423993	763	68	X	X	NNP
10_1101-2021_01_08_423993	763	69	,	,	,
10_1101-2021_01_08_423993	763	70	Guddat	Guddat	NNP
10_1101-2021_01_08_423993	763	71	LW	LW	NNP
10_1101-2021_01_08_423993	763	72	,	,	,
10_1101-2021_01_08_423993	763	73	Xu	Xu	NNP
10_1101-2021_01_08_423993	763	74	W	W	NNP
10_1101-2021_01_08_423993	763	75	,	,	,
10_1101-2021_01_08_423993	763	76	Xiao	Xiao	NNP
10_1101-2021_01_08_423993	763	77	G	G	NNP
10_1101-2021_01_08_423993	763	78	,	,	,
10_1101-2021_01_08_423993	763	79	Qin	Qin	NNP
10_1101-2021_01_08_423993	763	80	C	C	NNP
10_1101-2021_01_08_423993	763	81	,	,	,
10_1101-2021_01_08_423993	763	82	Shi	Shi	NNP
10_1101-2021_01_08_423993	763	83	Z	Z	NNP
10_1101-2021_01_08_423993	763	84	,	,	,
10_1101-2021_01_08_423993	763	85	Jiang	Jiang	NNP
10_1101-2021_01_08_423993	763	86	H	H	NNP
10_1101-2021_01_08_423993	763	87	,	,	,
10_1101-2021_01_08_423993	763	88	Rao	Rao	NNP
10_1101-2021_01_08_423993	763	89	Z	Z	NNP
10_1101-2021_01_08_423993	763	90	&	&	CC
10_1101-2021_01_08_423993	763	91	Yang	Yang	NNP
10_1101-2021_01_08_423993	763	92	H	H	NNP
10_1101-2021_01_08_423993	763	93	(	(	-LRB-
10_1101-2021_01_08_423993	763	94	2020	2020	CD
10_1101-2021_01_08_423993	763	95	)	)	-RRB-
10_1101-2021_01_08_423993	763	96	Structure	structure	NN
10_1101-2021_01_08_423993	763	97	of	of	IN
10_1101-2021_01_08_423993	763	98	Mpro	Mpro	NNP
10_1101-2021_01_08_423993	763	99	from	from	IN
10_1101-2021_01_08_423993	763	100	SARS	SARS	NNP
10_1101-2021_01_08_423993	763	101	-	-	HYPH
10_1101-2021_01_08_423993	763	102	CoV-2	CoV-2	NNP
10_1101-2021_01_08_423993	763	103	and	and	CC
10_1101-2021_01_08_423993	763	104	discovery	discovery	NN
10_1101-2021_01_08_423993	763	105	of	of	IN
10_1101-2021_01_08_423993	763	106	its	-PRON-	PRP$
10_1101-2021_01_08_423993	763	107	inhibitors	inhibitor	NNS
10_1101-2021_01_08_423993	763	108	.	.	.
10_1101-2021_01_08_423993	764	1	Nature	nature	NN
10_1101-2021_01_08_423993	764	2	582	582	CD
10_1101-2021_01_08_423993	764	3	,	,	,
10_1101-2021_01_08_423993	764	4	289–293	289–293	CD
10_1101-2021_01_08_423993	764	5	.	.	.
10_1101-2021_01_08_423993	765	1	85	85	CD
10_1101-2021_01_08_423993	765	2	.	.	.
10_1101-2021_01_08_423993	766	1	Baddock	baddock	IN
10_1101-2021_01_08_423993	766	2	HT	HT	NNP
10_1101-2021_01_08_423993	766	3	,	,	,
10_1101-2021_01_08_423993	766	4	Brolih	Brolih	NNP
10_1101-2021_01_08_423993	766	5	S	S	NNP
10_1101-2021_01_08_423993	766	6	,	,	,
10_1101-2021_01_08_423993	766	7	Yosaatmadja	Yosaatmadja	NNP
10_1101-2021_01_08_423993	766	8	Y	Y	NNP
10_1101-2021_01_08_423993	766	9	,	,	,
10_1101-2021_01_08_423993	766	10	Ratnaweera	Ratnaweera	NNP
10_1101-2021_01_08_423993	766	11	M	M	NNP
10_1101-2021_01_08_423993	766	12	,	,	,
10_1101-2021_01_08_423993	766	13	Bielinski	Bielinski	NNP
10_1101-2021_01_08_423993	766	14	M	M	NNP
10_1101-2021_01_08_423993	766	15	,	,	,
10_1101-2021_01_08_423993	766	16	Swift	Swift	NNP
10_1101-2021_01_08_423993	766	17	L	L	NNP
10_1101-2021_01_08_423993	766	18	,	,	,
10_1101-2021_01_08_423993	766	19	Cruz	Cruz	NNP
10_1101-2021_01_08_423993	766	20	-	-	HYPH
10_1101-2021_01_08_423993	766	21	Migoni	Migoni	NNP
10_1101-2021_01_08_423993	766	22	A	A	NNP
10_1101-2021_01_08_423993	766	23	,	,	,
10_1101-2021_01_08_423993	766	24	.CC	.CC	NFP
10_1101-2021_01_08_423993	766	25	-	-	:
10_1101-2021_01_08_423993	766	26	BY	by	IN
10_1101-2021_01_08_423993	766	27	4.0	4.0	CD
10_1101-2021_01_08_423993	766	28	International	international	JJ
10_1101-2021_01_08_423993	766	29	licensemade	licensemade	NN
10_1101-2021_01_08_423993	766	30	available	available	JJ
10_1101-2021_01_08_423993	766	31	under	under	IN
10_1101-2021_01_08_423993	766	32	a	a	DT
10_1101-2021_01_08_423993	766	33	(	(	-LRB-
10_1101-2021_01_08_423993	766	34	which	which	WDT
10_1101-2021_01_08_423993	766	35	was	be	VBD
10_1101-2021_01_08_423993	766	36	not	not	RB
10_1101-2021_01_08_423993	766	37	certified	certify	VBN
10_1101-2021_01_08_423993	766	38	by	by	IN
10_1101-2021_01_08_423993	766	39	peer	peer	NN
10_1101-2021_01_08_423993	766	40	review	review	NN
10_1101-2021_01_08_423993	766	41	)	)	-RRB-
10_1101-2021_01_08_423993	766	42	is	be	VBZ
10_1101-2021_01_08_423993	766	43	the	the	DT
10_1101-2021_01_08_423993	766	44	author	author	NN
10_1101-2021_01_08_423993	766	45	/	/	SYM
10_1101-2021_01_08_423993	766	46	funder	funder	NN
10_1101-2021_01_08_423993	766	47	,	,	,
10_1101-2021_01_08_423993	766	48	who	who	WP
10_1101-2021_01_08_423993	766	49	has	have	VBZ
10_1101-2021_01_08_423993	766	50	granted	grant	VBN
10_1101-2021_01_08_423993	766	51	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	766	52	a	a	DT
10_1101-2021_01_08_423993	766	53	license	license	NN
10_1101-2021_01_08_423993	766	54	to	to	TO
10_1101-2021_01_08_423993	766	55	display	display	VB
10_1101-2021_01_08_423993	766	56	the	the	DT
10_1101-2021_01_08_423993	766	57	preprint	preprint	NN
10_1101-2021_01_08_423993	766	58	in	in	IN
10_1101-2021_01_08_423993	766	59	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	766	60	.	.	.
10_1101-2021_01_08_423993	767	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	767	2	is	be	VBZ
10_1101-2021_01_08_423993	767	3	The	the	DT
10_1101-2021_01_08_423993	767	4	copyright	copyright	NN
10_1101-2021_01_08_423993	767	5	holder	holder	NN
10_1101-2021_01_08_423993	767	6	for	for	IN
10_1101-2021_01_08_423993	767	7	this	this	DT
10_1101-2021_01_08_423993	767	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	767	9	version	version	NN
10_1101-2021_01_08_423993	767	10	posted	post	VBD
10_1101-2021_01_08_423993	767	11	January	January	NNP
10_1101-2021_01_08_423993	767	12	8	8	CD
10_1101-2021_01_08_423993	767	13	,	,	,
10_1101-2021_01_08_423993	767	14	2021	2021	CD
10_1101-2021_01_08_423993	767	15	.	.	.
10_1101-2021_01_08_423993	767	16	;	;	:
10_1101-2021_01_08_423993	767	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	767	18	:	:	:
10_1101-2021_01_08_423993	767	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	767	20	preprint	preprint	NN
10_1101-2021_01_08_423993	767	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	767	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	767	23	Morris	Morris	NNP
10_1101-2021_01_08_423993	767	24	GM	GM	NNP
10_1101-2021_01_08_423993	767	25	,	,	,
10_1101-2021_01_08_423993	767	26	Schofield	Schofield	NNP
10_1101-2021_01_08_423993	767	27	CJ	CJ	NNP
10_1101-2021_01_08_423993	767	28	,	,	,
10_1101-2021_01_08_423993	767	29	Gileadi	Gileadi	NNP
10_1101-2021_01_08_423993	767	30	O	O	NNP
10_1101-2021_01_08_423993	767	31	&	&	CC
10_1101-2021_01_08_423993	767	32	McHugh	McHugh	NNP
10_1101-2021_01_08_423993	767	33	PJ	PJ	NNP
10_1101-2021_01_08_423993	767	34	(	(	-LRB-
10_1101-2021_01_08_423993	767	35	2020	2020	CD
10_1101-2021_01_08_423993	767	36	)	)	-RRB-
10_1101-2021_01_08_423993	767	37	Characterisation	characterisation	NN
10_1101-2021_01_08_423993	767	38	of	of	IN
10_1101-2021_01_08_423993	767	39	the	the	DT
10_1101-2021_01_08_423993	767	40	SARS	SARS	NNP
10_1101-2021_01_08_423993	767	41	-	-	HYPH
10_1101-2021_01_08_423993	767	42	CoV-	CoV-	NNP
10_1101-2021_01_08_423993	767	43	2	2	CD
10_1101-2021_01_08_423993	767	44	ExoN	ExoN	NNP
10_1101-2021_01_08_423993	767	45	(	(	-LRB-
10_1101-2021_01_08_423993	767	46	nsp14<sup>ExoN</sup>-nsp10	nsp14<sup>exon</sup>-nsp10	RB
10_1101-2021_01_08_423993	767	47	)	)	-RRB-
10_1101-2021_01_08_423993	767	48	complex	complex	NN
10_1101-2021_01_08_423993	767	49	:	:	:
10_1101-2021_01_08_423993	767	50	implications	implication	NNS
10_1101-2021_01_08_423993	767	51	for	for	IN
10_1101-2021_01_08_423993	767	52	its	-PRON-	PRP$
10_1101-2021_01_08_423993	767	53	role	role	NN
10_1101-2021_01_08_423993	767	54	in	in	IN
10_1101-2021_01_08_423993	767	55	viral	viral	JJ
10_1101-2021_01_08_423993	767	56	genome	genome	NN
10_1101-2021_01_08_423993	767	57	stability	stability	NN
10_1101-2021_01_08_423993	767	58	and	and	CC
10_1101-2021_01_08_423993	767	59	inhibitor	inhibitor	NN
10_1101-2021_01_08_423993	767	60	identification	identification	NN
10_1101-2021_01_08_423993	767	61	.	.	.
10_1101-2021_01_08_423993	768	1	bioRxiv	biorxiv	NN
10_1101-2021_01_08_423993	768	2	,	,	,
10_1101-2021_01_08_423993	768	3	2020.08.13.248211	2020.08.13.248211	CD
10_1101-2021_01_08_423993	768	4	.	.	.
10_1101-2021_01_08_423993	769	1	86	86	CD
10_1101-2021_01_08_423993	769	2	.	.	.
10_1101-2021_01_08_423993	770	1	Skinner	Skinner	NNP
10_1101-2021_01_08_423993	770	2	MD	MD	NNP
10_1101-2021_01_08_423993	770	3	,	,	,
10_1101-2021_01_08_423993	770	4	Lahmek	Lahmek	NNP
10_1101-2021_01_08_423993	770	5	P	P	NNP
10_1101-2021_01_08_423993	770	6	,	,	,
10_1101-2021_01_08_423993	770	7	Pham	Pham	NNP
10_1101-2021_01_08_423993	770	8	H	H	NNP
10_1101-2021_01_08_423993	770	9	&	&	CC
10_1101-2021_01_08_423993	770	10	Aubin	Aubin	NNP
10_1101-2021_01_08_423993	770	11	HJ	HJ	NNP
10_1101-2021_01_08_423993	770	12	(	(	-LRB-
10_1101-2021_01_08_423993	770	13	2014	2014	CD
10_1101-2021_01_08_423993	770	14	)	)	-RRB-
10_1101-2021_01_08_423993	770	15	Disulfiram	Disulfiram	NNP
10_1101-2021_01_08_423993	770	16	efficacy	efficacy	NN
10_1101-2021_01_08_423993	770	17	in	in	IN
10_1101-2021_01_08_423993	770	18	the	the	DT
10_1101-2021_01_08_423993	770	19	treatment	treatment	NN
10_1101-2021_01_08_423993	770	20	of	of	IN
10_1101-2021_01_08_423993	770	21	alcohol	alcohol	NN
10_1101-2021_01_08_423993	770	22	dependence	dependence	NN
10_1101-2021_01_08_423993	770	23	:	:	:
10_1101-2021_01_08_423993	770	24	A	a	DT
10_1101-2021_01_08_423993	770	25	meta	meta	JJ
10_1101-2021_01_08_423993	770	26	-	-	HYPH
10_1101-2021_01_08_423993	770	27	analysis	analysis	NN
10_1101-2021_01_08_423993	770	28	.	.	.
10_1101-2021_01_08_423993	771	1	PLoS	plos	ADD
10_1101-2021_01_08_423993	771	2	One	one	CD
10_1101-2021_01_08_423993	771	3	9	9	CD
10_1101-2021_01_08_423993	771	4	.	.	.
10_1101-2021_01_08_423993	772	1	.CC	.CC	NFP
10_1101-2021_01_08_423993	772	2	-	-	:
10_1101-2021_01_08_423993	772	3	BY	by	IN
10_1101-2021_01_08_423993	772	4	4.0	4.0	CD
10_1101-2021_01_08_423993	772	5	International	international	JJ
10_1101-2021_01_08_423993	772	6	licensemade	licensemade	NN
10_1101-2021_01_08_423993	772	7	available	available	JJ
10_1101-2021_01_08_423993	772	8	under	under	IN
10_1101-2021_01_08_423993	772	9	a	a	DT
10_1101-2021_01_08_423993	772	10	(	(	-LRB-
10_1101-2021_01_08_423993	772	11	which	which	WDT
10_1101-2021_01_08_423993	772	12	was	be	VBD
10_1101-2021_01_08_423993	772	13	not	not	RB
10_1101-2021_01_08_423993	772	14	certified	certify	VBN
10_1101-2021_01_08_423993	772	15	by	by	IN
10_1101-2021_01_08_423993	772	16	peer	peer	NN
10_1101-2021_01_08_423993	772	17	review	review	NN
10_1101-2021_01_08_423993	772	18	)	)	-RRB-
10_1101-2021_01_08_423993	772	19	is	be	VBZ
10_1101-2021_01_08_423993	772	20	the	the	DT
10_1101-2021_01_08_423993	772	21	author	author	NN
10_1101-2021_01_08_423993	772	22	/	/	SYM
10_1101-2021_01_08_423993	772	23	funder	funder	NN
10_1101-2021_01_08_423993	772	24	,	,	,
10_1101-2021_01_08_423993	772	25	who	who	WP
10_1101-2021_01_08_423993	772	26	has	have	VBZ
10_1101-2021_01_08_423993	772	27	granted	grant	VBN
10_1101-2021_01_08_423993	772	28	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	772	29	a	a	DT
10_1101-2021_01_08_423993	772	30	license	license	NN
10_1101-2021_01_08_423993	772	31	to	to	TO
10_1101-2021_01_08_423993	772	32	display	display	VB
10_1101-2021_01_08_423993	772	33	the	the	DT
10_1101-2021_01_08_423993	772	34	preprint	preprint	NN
10_1101-2021_01_08_423993	772	35	in	in	IN
10_1101-2021_01_08_423993	772	36	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	772	37	.	.	.
10_1101-2021_01_08_423993	773	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	773	2	is	be	VBZ
10_1101-2021_01_08_423993	773	3	The	the	DT
10_1101-2021_01_08_423993	773	4	copyright	copyright	NN
10_1101-2021_01_08_423993	773	5	holder	holder	NN
10_1101-2021_01_08_423993	773	6	for	for	IN
10_1101-2021_01_08_423993	773	7	this	this	DT
10_1101-2021_01_08_423993	773	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	773	9	version	version	NN
10_1101-2021_01_08_423993	773	10	posted	post	VBD
10_1101-2021_01_08_423993	773	11	January	January	NNP
10_1101-2021_01_08_423993	773	12	8	8	CD
10_1101-2021_01_08_423993	773	13	,	,	,
10_1101-2021_01_08_423993	773	14	2021	2021	CD
10_1101-2021_01_08_423993	773	15	.	.	.
10_1101-2021_01_08_423993	773	16	;	;	:
10_1101-2021_01_08_423993	773	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	773	18	:	:	:
10_1101-2021_01_08_423993	773	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	773	20	preprint	preprint	NN
10_1101-2021_01_08_423993	773	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	773	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	773	23	FIGURES	FIGURES	NNP
10_1101-2021_01_08_423993	773	24	Figure	figure	NN
10_1101-2021_01_08_423993	773	25	1	1	CD
10_1101-2021_01_08_423993	773	26	:	:	:
10_1101-2021_01_08_423993	773	27	Overall	overall	JJ
10_1101-2021_01_08_423993	773	28	architecture	architecture	NN
10_1101-2021_01_08_423993	773	29	of	of	IN
10_1101-2021_01_08_423993	773	30	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	773	31	.	.	.
10_1101-2021_01_08_423993	774	1	A.	A.	NNP
10_1101-2021_01_08_423993	775	1	A	a	DT
10_1101-2021_01_08_423993	775	2	cartoon	cartoon	NN
10_1101-2021_01_08_423993	775	3	representation	representation	NN
10_1101-2021_01_08_423993	775	4	of	of	IN
10_1101-2021_01_08_423993	775	5	the	the	DT
10_1101-2021_01_08_423993	775	6	structure	structure	NN
10_1101-2021_01_08_423993	775	7	of	of	IN
10_1101-2021_01_08_423993	775	8	human	human	JJ
10_1101-2021_01_08_423993	775	9	SNM1C/	SNM1C/	NNP
10_1101-2021_01_08_423993	775	10	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	775	11	.	.	.
10_1101-2021_01_08_423993	776	1	The	the	DT
10_1101-2021_01_08_423993	776	2	active	active	JJ
10_1101-2021_01_08_423993	776	3	site	site	NN
10_1101-2021_01_08_423993	776	4	containing	contain	VBG
10_1101-2021_01_08_423993	776	5	MBL	MBL	NNP
10_1101-2021_01_08_423993	776	6	domain	domain	NN
10_1101-2021_01_08_423993	776	7	is	be	VBZ
10_1101-2021_01_08_423993	776	8	in	in	IN
10_1101-2021_01_08_423993	776	9	pink	pink	NN
10_1101-2021_01_08_423993	776	10	;	;	:
10_1101-2021_01_08_423993	776	11	the	the	DT
10_1101-2021_01_08_423993	776	12	β	β	NNP
10_1101-2021_01_08_423993	776	13	-	-	HYPH
10_1101-2021_01_08_423993	776	14	CASP	CASP	NNP
10_1101-2021_01_08_423993	776	15	domain	domain	NN
10_1101-2021_01_08_423993	776	16	(	(	-LRB-
10_1101-2021_01_08_423993	776	17	white	white	JJ
10_1101-2021_01_08_423993	776	18	)	)	-RRB-
10_1101-2021_01_08_423993	776	19	contains	contain	VBZ
10_1101-2021_01_08_423993	776	20	a	a	DT
10_1101-2021_01_08_423993	776	21	novel	novel	JJ
10_1101-2021_01_08_423993	776	22	zinc	zinc	NN
10_1101-2021_01_08_423993	776	23	-	-	HYPH
10_1101-2021_01_08_423993	776	24	finger	finger	NN
10_1101-2021_01_08_423993	776	25	like	like	IN
10_1101-2021_01_08_423993	776	26	motif	motif	NN
10_1101-2021_01_08_423993	776	27	,	,	,
10_1101-2021_01_08_423993	776	28	that	that	WDT
10_1101-2021_01_08_423993	776	29	has	have	VBZ
10_1101-2021_01_08_423993	776	30	not	not	RB
10_1101-2021_01_08_423993	776	31	been	be	VBN
10_1101-2021_01_08_423993	776	32	identified	identify	VBN
10_1101-2021_01_08_423993	776	33	in	in	IN
10_1101-2021_01_08_423993	776	34	other	other	JJ
10_1101-2021_01_08_423993	776	35	MBL/	MBL/	NNP
10_1101-2021_01_08_423993	776	36	β	β	NNP
10_1101-2021_01_08_423993	776	37	-	-	HYPH
10_1101-2021_01_08_423993	776	38	CASP	CASP	NNP
10_1101-2021_01_08_423993	776	39	nucleic	nucleic	NN
10_1101-2021_01_08_423993	776	40	acid	acid	NN
10_1101-2021_01_08_423993	776	41	processing	processing	NN
10_1101-2021_01_08_423993	776	42	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	776	43	.	.	.
10_1101-2021_01_08_423993	777	1	The	the	DT
10_1101-2021_01_08_423993	777	2	three	three	CD
10_1101-2021_01_08_423993	777	3	zinc	zinc	NN
10_1101-2021_01_08_423993	777	4	ions	ion	NNS
10_1101-2021_01_08_423993	777	5	are	be	VBP
10_1101-2021_01_08_423993	777	6	represented	represent	VBN
10_1101-2021_01_08_423993	777	7	by	by	IN
10_1101-2021_01_08_423993	777	8	grey	grey	JJ
10_1101-2021_01_08_423993	777	9	spheres	sphere	NNS
10_1101-2021_01_08_423993	777	10	.	.	.
10_1101-2021_01_08_423993	778	1	B.	B.	NNP
10_1101-2021_01_08_423993	778	2	Topology	Topology	NNP
10_1101-2021_01_08_423993	778	3	diagram	diagram	NN
10_1101-2021_01_08_423993	778	4	of	of	IN
10_1101-2021_01_08_423993	778	5	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	778	6	protein	protein	NN
10_1101-2021_01_08_423993	778	7	.	.	.
10_1101-2021_01_08_423993	779	1	The	the	DT
10_1101-2021_01_08_423993	779	2	β	β	NN
10_1101-2021_01_08_423993	779	3	-	-	HYPH
10_1101-2021_01_08_423993	779	4	strands	strand	NNS
10_1101-2021_01_08_423993	779	5	are	be	VBP
10_1101-2021_01_08_423993	779	6	represented	represent	VBN
10_1101-2021_01_08_423993	779	7	arrows	arrow	NNS
10_1101-2021_01_08_423993	779	8	and	and	CC
10_1101-2021_01_08_423993	779	9	α	α	NNS
10_1101-2021_01_08_423993	779	10	-	-	HYPH
10_1101-2021_01_08_423993	779	11	helices	helix	NNS
10_1101-2021_01_08_423993	779	12	by	by	IN
10_1101-2021_01_08_423993	779	13	cylinders	cylinder	NNS
10_1101-2021_01_08_423993	779	14	.	.	.
10_1101-2021_01_08_423993	780	1	The	the	DT
10_1101-2021_01_08_423993	780	2	MBL	MBL	NNP
10_1101-2021_01_08_423993	780	3	domain	domain	NN
10_1101-2021_01_08_423993	780	4	(	(	-LRB-
10_1101-2021_01_08_423993	780	5	pink	pink	NN
10_1101-2021_01_08_423993	780	6	)	)	-RRB-
10_1101-2021_01_08_423993	780	7	has	have	VBZ
10_1101-2021_01_08_423993	780	8	the	the	DT
10_1101-2021_01_08_423993	780	9	typical	typical	JJ
10_1101-2021_01_08_423993	780	10	α	α	NNP
10_1101-2021_01_08_423993	780	11	/	/	SYM
10_1101-2021_01_08_423993	780	12	β	β	NNP
10_1101-2021_01_08_423993	780	13	-	-	HYPH
10_1101-2021_01_08_423993	780	14	β	β	NNP
10_1101-2021_01_08_423993	780	15	/	/	SYM
10_1101-2021_01_08_423993	780	16	α	α	NNP
10_1101-2021_01_08_423993	780	17	sandwich	sandwich	NN
10_1101-2021_01_08_423993	780	18	of	of	IN
10_1101-2021_01_08_423993	780	19	the	the	DT
10_1101-2021_01_08_423993	780	20	MBL	MBL	NNP
10_1101-2021_01_08_423993	780	21	superfamily	superfamily	RB
10_1101-2021_01_08_423993	780	22	,	,	,
10_1101-2021_01_08_423993	780	23	with	with	IN
10_1101-2021_01_08_423993	780	24	an	an	DT
10_1101-2021_01_08_423993	780	25	insert	insert	NN
10_1101-2021_01_08_423993	780	26	of	of	IN
10_1101-2021_01_08_423993	780	27	the	the	DT
10_1101-2021_01_08_423993	780	28	β	β	NNP
10_1101-2021_01_08_423993	780	29	-	-	HYPH
10_1101-2021_01_08_423993	780	30	CASP	CASP	NNP
10_1101-2021_01_08_423993	780	31	domain	domain	NN
10_1101-2021_01_08_423993	780	32	(	(	-LRB-
10_1101-2021_01_08_423993	780	33	white	white	JJ
10_1101-2021_01_08_423993	780	34	)	)	-RRB-
10_1101-2021_01_08_423993	780	35	between	between	IN
10_1101-2021_01_08_423993	780	36	the	the	DT
10_1101-2021_01_08_423993	780	37	small	small	JJ
10_1101-2021_01_08_423993	780	38	helix	helix	JJ
10_1101-2021_01_08_423993	780	39	α6	α6	NN
10_1101-2021_01_08_423993	780	40	and	and	CC
10_1101-2021_01_08_423993	780	41	helix	helix	NN
10_1101-2021_01_08_423993	780	42	α7	α7	NN
10_1101-2021_01_08_423993	780	43	.	.	.
10_1101-2021_01_08_423993	781	1	C.	C.	NNP
10_1101-2021_01_08_423993	781	2	Overlay	Overlay	NNP
10_1101-2021_01_08_423993	781	3	of	of	IN
10_1101-2021_01_08_423993	781	4	structures	structure	NNS
10_1101-2021_01_08_423993	781	5	of	of	IN
10_1101-2021_01_08_423993	781	6	the	the	DT
10_1101-2021_01_08_423993	781	7	human	human	JJ
10_1101-2021_01_08_423993	781	8	SNM1	SNM1	NNP
10_1101-2021_01_08_423993	781	9	Family	Family	NNP
10_1101-2021_01_08_423993	781	10	members	member	NNS
10_1101-2021_01_08_423993	781	11	:	:	:
10_1101-2021_01_08_423993	781	12	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	781	13	,	,	,
10_1101-2021_01_08_423993	781	14	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	781	15	and	and	CC
10_1101-2021_01_08_423993	781	16	SNM1C.	snm1c.	NN
10_1101-2021_01_08_423993	782	1	D.	D.	NNP
10_1101-2021_01_08_423993	782	2	Cartoon	Cartoon	NNP
10_1101-2021_01_08_423993	782	3	representation	representation	NN
10_1101-2021_01_08_423993	782	4	of	of	IN
10_1101-2021_01_08_423993	782	5	amino	amino	JJ
10_1101-2021_01_08_423993	782	6	acid	acid	NN
10_1101-2021_01_08_423993	782	7	sequence	sequence	NN
10_1101-2021_01_08_423993	782	8	alignment	alignment	NN
10_1101-2021_01_08_423993	782	9	for	for	IN
10_1101-2021_01_08_423993	782	10	human	human	JJ
10_1101-2021_01_08_423993	782	11	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	782	12	,	,	,
10_1101-2021_01_08_423993	782	13	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	782	14	and	and	CC
10_1101-2021_01_08_423993	782	15	SNM1C	snm1c	CD
10_1101-2021_01_08_423993	782	16	,	,	,
10_1101-2021_01_08_423993	782	17	showing	show	VBG
10_1101-2021_01_08_423993	782	18	the	the	DT
10_1101-2021_01_08_423993	782	19	conserved	conserve	VBN
10_1101-2021_01_08_423993	782	20	MBL	MBL	NNP
10_1101-2021_01_08_423993	782	21	and	and	CC
10_1101-2021_01_08_423993	782	22	b-	b-	XX
10_1101-2021_01_08_423993	782	23	CASP	casp	JJ
10_1101-2021_01_08_423993	782	24	domains	domain	NNS
10_1101-2021_01_08_423993	782	25	.	.	.
10_1101-2021_01_08_423993	783	1	.CC	.CC	NFP
10_1101-2021_01_08_423993	783	2	-	-	:
10_1101-2021_01_08_423993	783	3	BY	by	IN
10_1101-2021_01_08_423993	783	4	4.0	4.0	CD
10_1101-2021_01_08_423993	783	5	International	international	JJ
10_1101-2021_01_08_423993	783	6	licensemade	licensemade	NN
10_1101-2021_01_08_423993	783	7	available	available	JJ
10_1101-2021_01_08_423993	783	8	under	under	IN
10_1101-2021_01_08_423993	783	9	a	a	DT
10_1101-2021_01_08_423993	783	10	(	(	-LRB-
10_1101-2021_01_08_423993	783	11	which	which	WDT
10_1101-2021_01_08_423993	783	12	was	be	VBD
10_1101-2021_01_08_423993	783	13	not	not	RB
10_1101-2021_01_08_423993	783	14	certified	certify	VBN
10_1101-2021_01_08_423993	783	15	by	by	IN
10_1101-2021_01_08_423993	783	16	peer	peer	NN
10_1101-2021_01_08_423993	783	17	review	review	NN
10_1101-2021_01_08_423993	783	18	)	)	-RRB-
10_1101-2021_01_08_423993	783	19	is	be	VBZ
10_1101-2021_01_08_423993	783	20	the	the	DT
10_1101-2021_01_08_423993	783	21	author	author	NN
10_1101-2021_01_08_423993	783	22	/	/	SYM
10_1101-2021_01_08_423993	783	23	funder	funder	NN
10_1101-2021_01_08_423993	783	24	,	,	,
10_1101-2021_01_08_423993	783	25	who	who	WP
10_1101-2021_01_08_423993	783	26	has	have	VBZ
10_1101-2021_01_08_423993	783	27	granted	grant	VBN
10_1101-2021_01_08_423993	783	28	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	783	29	a	a	DT
10_1101-2021_01_08_423993	783	30	license	license	NN
10_1101-2021_01_08_423993	783	31	to	to	TO
10_1101-2021_01_08_423993	783	32	display	display	VB
10_1101-2021_01_08_423993	783	33	the	the	DT
10_1101-2021_01_08_423993	783	34	preprint	preprint	NN
10_1101-2021_01_08_423993	783	35	in	in	IN
10_1101-2021_01_08_423993	783	36	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	783	37	.	.	.
10_1101-2021_01_08_423993	784	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	784	2	is	be	VBZ
10_1101-2021_01_08_423993	784	3	The	the	DT
10_1101-2021_01_08_423993	784	4	copyright	copyright	NN
10_1101-2021_01_08_423993	784	5	holder	holder	NN
10_1101-2021_01_08_423993	784	6	for	for	IN
10_1101-2021_01_08_423993	784	7	this	this	DT
10_1101-2021_01_08_423993	784	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	784	9	version	version	NN
10_1101-2021_01_08_423993	784	10	posted	post	VBD
10_1101-2021_01_08_423993	784	11	January	January	NNP
10_1101-2021_01_08_423993	784	12	8	8	CD
10_1101-2021_01_08_423993	784	13	,	,	,
10_1101-2021_01_08_423993	784	14	2021	2021	CD
10_1101-2021_01_08_423993	784	15	.	.	.
10_1101-2021_01_08_423993	784	16	;	;	:
10_1101-2021_01_08_423993	784	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	784	18	:	:	:
10_1101-2021_01_08_423993	784	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	784	20	preprint	preprint	NN
10_1101-2021_01_08_423993	784	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	CD
10_1101-2021_01_08_423993	784	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	784	23	Figure	Figure	NNP
10_1101-2021_01_08_423993	784	24	2	2	CD
10_1101-2021_01_08_423993	784	25	:	:	:
10_1101-2021_01_08_423993	784	26	Active	active	JJ
10_1101-2021_01_08_423993	784	27	site	site	NN
10_1101-2021_01_08_423993	784	28	views	view	NNS
10_1101-2021_01_08_423993	784	29	of	of	IN
10_1101-2021_01_08_423993	784	30	human	human	JJ
10_1101-2021_01_08_423993	784	31	MBL/	MBL/	NNP
10_1101-2021_01_08_423993	784	32	β	β	NNP
10_1101-2021_01_08_423993	784	33	-	-	HYPH
10_1101-2021_01_08_423993	784	34	CASP	CASP	NNP
10_1101-2021_01_08_423993	784	35	nuclease	nuclease	NN
10_1101-2021_01_08_423993	784	36	family	family	NN
10_1101-2021_01_08_423993	784	37	enzymes	enzyme	NNS
10_1101-2021_01_08_423993	784	38	.	.	.
10_1101-2021_01_08_423993	785	1	Each	each	DT
10_1101-2021_01_08_423993	785	2	of	of	IN
10_1101-2021_01_08_423993	785	3	these	these	DT
10_1101-2021_01_08_423993	785	4	catalytic	catalytic	JJ
10_1101-2021_01_08_423993	785	5	sites	site	NNS
10_1101-2021_01_08_423993	785	6	contains	contain	VBZ
10_1101-2021_01_08_423993	785	7	4	4	CD
10_1101-2021_01_08_423993	785	8	highly	highly	RB
10_1101-2021_01_08_423993	785	9	conserved	conserve	VBN
10_1101-2021_01_08_423993	785	10	motifs	motif	NNS
10_1101-2021_01_08_423993	785	11	(	(	-LRB-
10_1101-2021_01_08_423993	785	12	1	1	CD
10_1101-2021_01_08_423993	785	13	-	-	SYM
10_1101-2021_01_08_423993	785	14	4	4	CD
10_1101-2021_01_08_423993	785	15	,	,	,
10_1101-2021_01_08_423993	785	16	in	in	IN
10_1101-2021_01_08_423993	785	17	red	red	NN
10_1101-2021_01_08_423993	785	18	)	)	-RRB-
10_1101-2021_01_08_423993	785	19	.	.	.
10_1101-2021_01_08_423993	786	1	Motif	motif	NN
10_1101-2021_01_08_423993	786	2	1	1	CD
10_1101-2021_01_08_423993	786	3	=	=	SYM
10_1101-2021_01_08_423993	786	4	Asp	Asp	NNP
10_1101-2021_01_08_423993	786	5	,	,	,
10_1101-2021_01_08_423993	786	6	motif	motif	NN
10_1101-2021_01_08_423993	786	7	2	2	CD
10_1101-2021_01_08_423993	786	8	=	=	SYM
10_1101-2021_01_08_423993	786	9	3	3	CD
10_1101-2021_01_08_423993	786	10	His	-PRON-	PRP$
10_1101-2021_01_08_423993	786	11	and	and	CC
10_1101-2021_01_08_423993	786	12	1	1	CD
10_1101-2021_01_08_423993	786	13	Asp	Asp	NNP
10_1101-2021_01_08_423993	786	14	(	(	-LRB-
10_1101-2021_01_08_423993	786	15	HxHxDH	HxHxDH	NNP
10_1101-2021_01_08_423993	786	16	)	)	-RRB-
10_1101-2021_01_08_423993	786	17	,	,	,
10_1101-2021_01_08_423993	786	18	motif	motif	NN
10_1101-2021_01_08_423993	786	19	3	3	CD
10_1101-2021_01_08_423993	786	20	=	=	NFP
10_1101-2021_01_08_423993	786	21	His	-PRON-	PRP$
10_1101-2021_01_08_423993	786	22	and	and	CC
10_1101-2021_01_08_423993	786	23	motif	motif	NN
10_1101-2021_01_08_423993	786	24	4	4	CD
10_1101-2021_01_08_423993	786	25	=	=	SYM
10_1101-2021_01_08_423993	786	26	Asp	Asp	NNP
10_1101-2021_01_08_423993	786	27	.	.	.
10_1101-2021_01_08_423993	787	1	A.	A.	NNP
10_1101-2021_01_08_423993	788	1	The	the	DT
10_1101-2021_01_08_423993	788	2	human	human	NN
10_1101-2021_01_08_423993	788	3	SNM1A	snm1a	NN
10_1101-2021_01_08_423993	788	4	active	active	JJ
10_1101-2021_01_08_423993	788	5	site	site	NN
10_1101-2021_01_08_423993	788	6	with	with	IN
10_1101-2021_01_08_423993	788	7	a	a	DT
10_1101-2021_01_08_423993	788	8	single	single	JJ
10_1101-2021_01_08_423993	788	9	octahedral	octahedral	JJ
10_1101-2021_01_08_423993	788	10	zinc	zinc	NN
10_1101-2021_01_08_423993	788	11	ion	ion	NNP
10_1101-2021_01_08_423993	788	12	(	(	-LRB-
10_1101-2021_01_08_423993	788	13	grey	grey	NNP
10_1101-2021_01_08_423993	788	14	)	)	-RRB-
10_1101-2021_01_08_423993	788	15	coordination	coordination	NN
10_1101-2021_01_08_423993	788	16	(	(	-LRB-
10_1101-2021_01_08_423993	788	17	PDB	PDB	NNP
10_1101-2021_01_08_423993	788	18	:	:	:
10_1101-2021_01_08_423993	788	19	5AHR	5AHR	NNP
10_1101-2021_01_08_423993	788	20	)	)	-RRB-
10_1101-2021_01_08_423993	788	21	.	.	.
10_1101-2021_01_08_423993	789	1	B.	B.	NNP
10_1101-2021_01_08_423993	790	1	The	the	DT
10_1101-2021_01_08_423993	790	2	active	active	JJ
10_1101-2021_01_08_423993	790	3	site	site	NN
10_1101-2021_01_08_423993	790	4	of	of	IN
10_1101-2021_01_08_423993	790	5	human	human	JJ
10_1101-2021_01_08_423993	790	6	SNM1B/	SNM1B/	NNP
10_1101-2021_01_08_423993	790	7	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	790	8	(	(	-LRB-
10_1101-2021_01_08_423993	790	9	PDB	PDB	NNP
10_1101-2021_01_08_423993	790	10	:	:	:
10_1101-2021_01_08_423993	790	11	7A1F	7a1f	CD
10_1101-2021_01_08_423993	790	12	)	)	-RRB-
10_1101-2021_01_08_423993	790	13	with	with	IN
10_1101-2021_01_08_423993	790	14	a	a	DT
10_1101-2021_01_08_423993	790	15	nickel	nickel	NN
10_1101-2021_01_08_423993	790	16	ion	ion	NN
10_1101-2021_01_08_423993	790	17	(	(	-LRB-
10_1101-2021_01_08_423993	790	18	green	green	JJ
10_1101-2021_01_08_423993	790	19	)	)	-RRB-
10_1101-2021_01_08_423993	790	20	and	and	CC
10_1101-2021_01_08_423993	790	21	an	an	DT
10_1101-2021_01_08_423993	790	22	iron	iron	NN
10_1101-2021_01_08_423993	790	23	ion	ion	NN
10_1101-2021_01_08_423993	790	24	(	(	-LRB-
10_1101-2021_01_08_423993	790	25	orange	orange	NN
10_1101-2021_01_08_423993	790	26	)	)	-RRB-
10_1101-2021_01_08_423993	790	27	with	with	IN
10_1101-2021_01_08_423993	790	28	a	a	DT
10_1101-2021_01_08_423993	790	29	coordinating	coordinate	VBG
10_1101-2021_01_08_423993	790	30	AMP	AMP	NNP
10_1101-2021_01_08_423993	790	31	molecule	molecule	NN
10_1101-2021_01_08_423993	790	32	.	.	.
10_1101-2021_01_08_423993	791	1	C.	C.	NNP
10_1101-2021_01_08_423993	791	2	Human	Human	NNP
10_1101-2021_01_08_423993	791	3	SNM1C/	SNM1C/	NNP
10_1101-2021_01_08_423993	791	4	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	791	5	(	(	-LRB-
10_1101-2021_01_08_423993	791	6	PDB	PDB	NNP
10_1101-2021_01_08_423993	791	7	:	:	:
10_1101-2021_01_08_423993	791	8	7AF1	7af1	LS
10_1101-2021_01_08_423993	791	9	)	)	-RRB-
10_1101-2021_01_08_423993	791	10	purified	purify	VBN
10_1101-2021_01_08_423993	791	11	in	in	IN
10_1101-2021_01_08_423993	791	12	the	the	DT
10_1101-2021_01_08_423993	791	13	absence	absence	NN
10_1101-2021_01_08_423993	791	14	of	of	IN
10_1101-2021_01_08_423993	791	15	IMAC	IMAC	NNP
10_1101-2021_01_08_423993	791	16	with	with	IN
10_1101-2021_01_08_423993	791	17	two	two	CD
10_1101-2021_01_08_423993	791	18	zinc	zinc	NN
10_1101-2021_01_08_423993	791	19	ions	ion	NNS
10_1101-2021_01_08_423993	791	20	(	(	-LRB-
10_1101-2021_01_08_423993	791	21	in	in	IN
10_1101-2021_01_08_423993	791	22	grey	grey	NNP
10_1101-2021_01_08_423993	791	23	)	)	-RRB-
10_1101-2021_01_08_423993	791	24	in	in	IN
10_1101-2021_01_08_423993	791	25	its	-PRON-	PRP$
10_1101-2021_01_08_423993	791	26	active	active	JJ
10_1101-2021_01_08_423993	791	27	site	site	NN
10_1101-2021_01_08_423993	791	28	.	.	.
10_1101-2021_01_08_423993	792	1	A	a	DT
10_1101-2021_01_08_423993	792	2	water	water	NN
10_1101-2021_01_08_423993	792	3	molecule	molecule	NN
10_1101-2021_01_08_423993	792	4	shared	share	VBN
10_1101-2021_01_08_423993	792	5	(	(	-LRB-
10_1101-2021_01_08_423993	792	6	asterisk	asterisk	NN
10_1101-2021_01_08_423993	792	7	*	*	NFP
10_1101-2021_01_08_423993	792	8	)	)	-RRB-
10_1101-2021_01_08_423993	792	9	between	between	IN
10_1101-2021_01_08_423993	792	10	the	the	DT
10_1101-2021_01_08_423993	792	11	two	two	CD
10_1101-2021_01_08_423993	792	12	metals	metal	NNS
10_1101-2021_01_08_423993	792	13	is	be	VBZ
10_1101-2021_01_08_423993	792	14	the	the	DT
10_1101-2021_01_08_423993	792	15	proposed	propose	VBN
10_1101-2021_01_08_423993	792	16	nucleophile	nucleophile	NN
10_1101-2021_01_08_423993	792	17	for	for	IN
10_1101-2021_01_08_423993	792	18	the	the	DT
10_1101-2021_01_08_423993	792	19	hydrolytic	hydrolytic	JJ
10_1101-2021_01_08_423993	792	20	reaction	reaction	NN
10_1101-2021_01_08_423993	792	21	.	.	.
10_1101-2021_01_08_423993	793	1	D.	D.	NNP
10_1101-2021_01_08_423993	793	2	The	the	DT
10_1101-2021_01_08_423993	793	3	active	active	JJ
10_1101-2021_01_08_423993	793	4	site	site	NN
10_1101-2021_01_08_423993	793	5	of	of	IN
10_1101-2021_01_08_423993	793	6	the	the	DT
10_1101-2021_01_08_423993	793	7	human	human	JJ
10_1101-2021_01_08_423993	793	8	RNA	RNA	NNP
10_1101-2021_01_08_423993	793	9	processing	processing	NN
10_1101-2021_01_08_423993	793	10	enzyme	enzyme	NNS
10_1101-2021_01_08_423993	793	11	CPSF73	CPSF73	NNP
10_1101-2021_01_08_423993	793	12	(	(	-LRB-
10_1101-2021_01_08_423993	793	13	PDB	PDB	NNP
10_1101-2021_01_08_423993	793	14	:	:	:
10_1101-2021_01_08_423993	793	15	2I7	2i7	CD
10_1101-2021_01_08_423993	793	16	T	t	NN
10_1101-2021_01_08_423993	793	17	)	)	-RRB-
10_1101-2021_01_08_423993	793	18	.	.	.
10_1101-2021_01_08_423993	794	1	The	the	DT
10_1101-2021_01_08_423993	794	2	second	second	JJ
10_1101-2021_01_08_423993	794	3	zinc	zinc	NN
10_1101-2021_01_08_423993	794	4	ion	ion	NN
10_1101-2021_01_08_423993	794	5	(	(	-LRB-
10_1101-2021_01_08_423993	794	6	M2	M2	NNP
10_1101-2021_01_08_423993	794	7	)	)	-RRB-
10_1101-2021_01_08_423993	794	8	is	be	VBZ
10_1101-2021_01_08_423993	794	9	coordinated	coordinate	VBN
10_1101-2021_01_08_423993	794	10	by	by	IN
10_1101-2021_01_08_423993	794	11	an	an	DT
10_1101-2021_01_08_423993	794	12	additional	additional	JJ
10_1101-2021_01_08_423993	794	13	histidine	histidine	NN
10_1101-2021_01_08_423993	794	14	residue	residue	NN
10_1101-2021_01_08_423993	794	15	(	(	-LRB-
10_1101-2021_01_08_423993	794	16	His	-PRON-	PRP$
10_1101-2021_01_08_423993	794	17	418	418	CD
10_1101-2021_01_08_423993	794	18	)	)	-RRB-
10_1101-2021_01_08_423993	794	19	which	which	WDT
10_1101-2021_01_08_423993	794	20	has	have	VBZ
10_1101-2021_01_08_423993	794	21	no	no	DT
10_1101-2021_01_08_423993	794	22	counterpart	counterpart	NN
10_1101-2021_01_08_423993	794	23	in	in	IN
10_1101-2021_01_08_423993	794	24	the	the	DT
10_1101-2021_01_08_423993	794	25	SNM1	SNM1	NNP
10_1101-2021_01_08_423993	794	26	proteins	protein	NNS
10_1101-2021_01_08_423993	794	27	.	.	.
10_1101-2021_01_08_423993	795	1	E.	E.	NNP
10_1101-2021_01_08_423993	795	2	The	the	DT
10_1101-2021_01_08_423993	795	3	active	active	JJ
10_1101-2021_01_08_423993	795	4	site	site	NN
10_1101-2021_01_08_423993	795	5	of	of	IN
10_1101-2021_01_08_423993	795	6	human	human	JJ
10_1101-2021_01_08_423993	795	7	SNM1C/	SNM1C/	NNP
10_1101-2021_01_08_423993	795	8	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	795	9	(	(	-LRB-
10_1101-2021_01_08_423993	795	10	PDB	PDB	NNP
10_1101-2021_01_08_423993	795	11	:	:	:
10_1101-2021_01_08_423993	795	12	6TT5	6tt5	LS
10_1101-2021_01_08_423993	795	13	)	)	-RRB-
10_1101-2021_01_08_423993	795	14	purified	purify	VBN
10_1101-2021_01_08_423993	795	15	with	with	IN
10_1101-2021_01_08_423993	795	16	IMAC	IMAC	NNP
10_1101-2021_01_08_423993	795	17	.	.	.
10_1101-2021_01_08_423993	796	1	A	a	DT
10_1101-2021_01_08_423993	796	2	nickel	nickel	NN
10_1101-2021_01_08_423993	796	3	ion	ion	NN
10_1101-2021_01_08_423993	796	4	is	be	VBZ
10_1101-2021_01_08_423993	796	5	present	present	JJ
10_1101-2021_01_08_423993	796	6	in	in	IN
10_1101-2021_01_08_423993	796	7	the	the	DT
10_1101-2021_01_08_423993	796	8	first	first	JJ
10_1101-2021_01_08_423993	796	9	metal	metal	NN
10_1101-2021_01_08_423993	796	10	coordination	coordination	NN
10_1101-2021_01_08_423993	796	11	site	site	NN
10_1101-2021_01_08_423993	796	12	.	.	.
10_1101-2021_01_08_423993	797	1	.CC	.CC	NFP
10_1101-2021_01_08_423993	797	2	-	-	:
10_1101-2021_01_08_423993	797	3	BY	by	IN
10_1101-2021_01_08_423993	797	4	4.0	4.0	CD
10_1101-2021_01_08_423993	797	5	International	international	JJ
10_1101-2021_01_08_423993	797	6	licensemade	licensemade	NN
10_1101-2021_01_08_423993	797	7	available	available	JJ
10_1101-2021_01_08_423993	797	8	under	under	IN
10_1101-2021_01_08_423993	797	9	a	a	DT
10_1101-2021_01_08_423993	797	10	(	(	-LRB-
10_1101-2021_01_08_423993	797	11	which	which	WDT
10_1101-2021_01_08_423993	797	12	was	be	VBD
10_1101-2021_01_08_423993	797	13	not	not	RB
10_1101-2021_01_08_423993	797	14	certified	certify	VBN
10_1101-2021_01_08_423993	797	15	by	by	IN
10_1101-2021_01_08_423993	797	16	peer	peer	NN
10_1101-2021_01_08_423993	797	17	review	review	NN
10_1101-2021_01_08_423993	797	18	)	)	-RRB-
10_1101-2021_01_08_423993	797	19	is	be	VBZ
10_1101-2021_01_08_423993	797	20	the	the	DT
10_1101-2021_01_08_423993	797	21	author	author	NN
10_1101-2021_01_08_423993	797	22	/	/	SYM
10_1101-2021_01_08_423993	797	23	funder	funder	NN
10_1101-2021_01_08_423993	797	24	,	,	,
10_1101-2021_01_08_423993	797	25	who	who	WP
10_1101-2021_01_08_423993	797	26	has	have	VBZ
10_1101-2021_01_08_423993	797	27	granted	grant	VBN
10_1101-2021_01_08_423993	797	28	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	797	29	a	a	DT
10_1101-2021_01_08_423993	797	30	license	license	NN
10_1101-2021_01_08_423993	797	31	to	to	TO
10_1101-2021_01_08_423993	797	32	display	display	VB
10_1101-2021_01_08_423993	797	33	the	the	DT
10_1101-2021_01_08_423993	797	34	preprint	preprint	NN
10_1101-2021_01_08_423993	797	35	in	in	IN
10_1101-2021_01_08_423993	797	36	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	797	37	.	.	.
10_1101-2021_01_08_423993	798	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	798	2	is	be	VBZ
10_1101-2021_01_08_423993	798	3	The	the	DT
10_1101-2021_01_08_423993	798	4	copyright	copyright	NN
10_1101-2021_01_08_423993	798	5	holder	holder	NN
10_1101-2021_01_08_423993	798	6	for	for	IN
10_1101-2021_01_08_423993	798	7	this	this	DT
10_1101-2021_01_08_423993	798	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	798	9	version	version	NN
10_1101-2021_01_08_423993	798	10	posted	post	VBD
10_1101-2021_01_08_423993	798	11	January	January	NNP
10_1101-2021_01_08_423993	798	12	8	8	CD
10_1101-2021_01_08_423993	798	13	,	,	,
10_1101-2021_01_08_423993	798	14	2021	2021	CD
10_1101-2021_01_08_423993	798	15	.	.	.
10_1101-2021_01_08_423993	798	16	;	;	:
10_1101-2021_01_08_423993	798	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	798	18	:	:	:
10_1101-2021_01_08_423993	798	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	798	20	preprint	preprint	NN
10_1101-2021_01_08_423993	798	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	CD
10_1101-2021_01_08_423993	798	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	798	23	Figure	Figure	NNP
10_1101-2021_01_08_423993	798	24	3	3	CD
10_1101-2021_01_08_423993	798	25	:	:	:
10_1101-2021_01_08_423993	798	26	Comparison	comparison	NN
10_1101-2021_01_08_423993	798	27	of	of	IN
10_1101-2021_01_08_423993	798	28	a	a	DT
10_1101-2021_01_08_423993	798	29	novel	novel	JJ
10_1101-2021_01_08_423993	798	30	zinc	zinc	NN
10_1101-2021_01_08_423993	798	31	-	-	HYPH
10_1101-2021_01_08_423993	798	32	finger	finger	NN
10_1101-2021_01_08_423993	798	33	like	like	IN
10_1101-2021_01_08_423993	798	34	motif	motif	NN
10_1101-2021_01_08_423993	798	35	in	in	IN
10_1101-2021_01_08_423993	798	36	the	the	DT
10_1101-2021_01_08_423993	798	37	β	β	NNP
10_1101-2021_01_08_423993	798	38	-	-	HYPH
10_1101-2021_01_08_423993	798	39	CASP	CASP	NNP
10_1101-2021_01_08_423993	798	40	domain	domain	NN
10_1101-2021_01_08_423993	798	41	of	of	IN
10_1101-2021_01_08_423993	798	42	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	798	43	with	with	IN
10_1101-2021_01_08_423993	798	44	a	a	DT
10_1101-2021_01_08_423993	798	45	canonical	canonical	JJ
10_1101-2021_01_08_423993	798	46	zinc-	zinc-	JJ
10_1101-2021_01_08_423993	798	47	finger	finger	NN
10_1101-2021_01_08_423993	798	48	motif	motif	NN
10_1101-2021_01_08_423993	798	49	.	.	.
10_1101-2021_01_08_423993	799	1	A.	A.	NNP
10_1101-2021_01_08_423993	800	1	Cartoon	cartoon	NN
10_1101-2021_01_08_423993	800	2	representation	representation	NN
10_1101-2021_01_08_423993	800	3	of	of	IN
10_1101-2021_01_08_423993	800	4	the	the	DT
10_1101-2021_01_08_423993	800	5	classical	classical	JJ
10_1101-2021_01_08_423993	800	6	Cys2His2	Cys2His2	NNP
10_1101-2021_01_08_423993	800	7	zinc	zinc	NN
10_1101-2021_01_08_423993	800	8	-	-	HYPH
10_1101-2021_01_08_423993	800	9	finger	finger	NN
10_1101-2021_01_08_423993	800	10	motif	motif	NN
10_1101-2021_01_08_423993	800	11	,	,	,
10_1101-2021_01_08_423993	800	12	from	from	IN
10_1101-2021_01_08_423993	800	13	transcription	transcription	NN
10_1101-2021_01_08_423993	800	14	factor	factor	NNP
10_1101-2021_01_08_423993	800	15	SP1F2	SP1F2	NNP
10_1101-2021_01_08_423993	800	16	(	(	-LRB-
10_1101-2021_01_08_423993	800	17	PDB	PDB	NNP
10_1101-2021_01_08_423993	800	18	code	code	NN
10_1101-2021_01_08_423993	800	19	:	:	:
10_1101-2021_01_08_423993	800	20	1SP2	1sp2	CD
10_1101-2021_01_08_423993	800	21	)	)	-RRB-
10_1101-2021_01_08_423993	800	22	.	.	.
10_1101-2021_01_08_423993	801	1	This	this	DT
10_1101-2021_01_08_423993	801	2	has	have	VBZ
10_1101-2021_01_08_423993	801	3	a	a	DT
10_1101-2021_01_08_423993	801	4	ββα	ββα	NN
10_1101-2021_01_08_423993	801	5	fold	fold	VB
10_1101-2021_01_08_423993	801	6	,	,	,
10_1101-2021_01_08_423993	801	7	where	where	WRB
10_1101-2021_01_08_423993	801	8	two	two	CD
10_1101-2021_01_08_423993	801	9	Cys-	cys-	CD
10_1101-2021_01_08_423993	801	10	and	and	CC
10_1101-2021_01_08_423993	801	11	two	two	CD
10_1101-2021_01_08_423993	801	12	His	-PRON-	PRP$
10_1101-2021_01_08_423993	801	13	-	-	HYPH
10_1101-2021_01_08_423993	801	14	residues	residue	NNS
10_1101-2021_01_08_423993	801	15	are	be	VBP
10_1101-2021_01_08_423993	801	16	involved	involve	VBN
10_1101-2021_01_08_423993	801	17	in	in	IN
10_1101-2021_01_08_423993	801	18	zinc	zinc	NN
10_1101-2021_01_08_423993	801	19	ion	ion	NN
10_1101-2021_01_08_423993	801	20	coordination	coordination	NN
10_1101-2021_01_08_423993	801	21	and	and	CC
10_1101-2021_01_08_423993	801	22	the	the	DT
10_1101-2021_01_08_423993	801	23	sidechains	sidechain	NNS
10_1101-2021_01_08_423993	801	24	of	of	IN
10_1101-2021_01_08_423993	801	25	three	three	CD
10_1101-2021_01_08_423993	801	26	conserved	conserved	JJ
10_1101-2021_01_08_423993	801	27	hydrophobic	hydrophobic	NN
10_1101-2021_01_08_423993	801	28	residues	residue	NNS
10_1101-2021_01_08_423993	801	29	are	be	VBP
10_1101-2021_01_08_423993	801	30	shown	show	VBN
10_1101-2021_01_08_423993	801	31	.	.	.
10_1101-2021_01_08_423993	802	1	B.	B.	NNP
10_1101-2021_01_08_423993	803	1	The	the	DT
10_1101-2021_01_08_423993	803	2	β	β	NNP
10_1101-2021_01_08_423993	803	3	-	-	HYPH
10_1101-2021_01_08_423993	803	4	CASP	CASP	NNP
10_1101-2021_01_08_423993	803	5	region	region	NN
10_1101-2021_01_08_423993	803	6	of	of	IN
10_1101-2021_01_08_423993	803	7	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	803	8	has	have	VBZ
10_1101-2021_01_08_423993	803	9	a	a	DT
10_1101-2021_01_08_423993	803	10	novel	novel	JJ
10_1101-2021_01_08_423993	803	11	zinc	zinc	NN
10_1101-2021_01_08_423993	803	12	-	-	HYPH
10_1101-2021_01_08_423993	803	13	finger	finger	NN
10_1101-2021_01_08_423993	803	14	like	like	IN
10_1101-2021_01_08_423993	803	15	motif	motif	NN
10_1101-2021_01_08_423993	803	16	.	.	.
10_1101-2021_01_08_423993	804	1	The	the	DT
10_1101-2021_01_08_423993	804	2	inset	inset	NN
10_1101-2021_01_08_423993	804	3	shows	show	VBZ
10_1101-2021_01_08_423993	804	4	the	the	DT
10_1101-2021_01_08_423993	804	5	four	four	CD
10_1101-2021_01_08_423993	804	6	residues	residue	NNS
10_1101-2021_01_08_423993	804	7	(	(	-LRB-
10_1101-2021_01_08_423993	804	8	two	two	CD
10_1101-2021_01_08_423993	804	9	His	-PRON-	PRP$
10_1101-2021_01_08_423993	804	10	and	and	CC
10_1101-2021_01_08_423993	804	11	two	two	CD
10_1101-2021_01_08_423993	804	12	Cys	Cys	NNP
10_1101-2021_01_08_423993	804	13	)	)	-RRB-
10_1101-2021_01_08_423993	804	14	coordinating	coordinate	VBG
10_1101-2021_01_08_423993	804	15	the	the	DT
10_1101-2021_01_08_423993	804	16	zinc	zinc	NN
10_1101-2021_01_08_423993	804	17	ion	ion	NN
10_1101-2021_01_08_423993	804	18	(	(	-LRB-
10_1101-2021_01_08_423993	804	19	grey	grey	NNP
10_1101-2021_01_08_423993	804	20	)	)	-RRB-
10_1101-2021_01_08_423993	804	21	.	.	.
10_1101-2021_01_08_423993	805	1	The	the	DT
10_1101-2021_01_08_423993	805	2	Fo	Fo	NNP
10_1101-2021_01_08_423993	805	3	̶	̶	NNP
10_1101-2021_01_08_423993	805	4	Fc	Fc	NNP
10_1101-2021_01_08_423993	805	5	electron-	electron-	NN
10_1101-2021_01_08_423993	805	6	density	density	NN
10_1101-2021_01_08_423993	805	7	map	map	NN
10_1101-2021_01_08_423993	805	8	(	(	-LRB-
10_1101-2021_01_08_423993	805	9	scaled	scale	VBN
10_1101-2021_01_08_423993	805	10	to	to	IN
10_1101-2021_01_08_423993	805	11	2.5σ	2.5σ	CD
10_1101-2021_01_08_423993	805	12	in	in	IN
10_1101-2021_01_08_423993	805	13	PyMOL	PyMOL	NNP
10_1101-2021_01_08_423993	805	14	)	)	-RRB-
10_1101-2021_01_08_423993	805	15	surrounding	surround	VBG
10_1101-2021_01_08_423993	805	16	the	the	DT
10_1101-2021_01_08_423993	805	17	zinc	zinc	NN
10_1101-2021_01_08_423993	805	18	ion	ion	NN
10_1101-2021_01_08_423993	805	19	before	before	IN
10_1101-2021_01_08_423993	805	20	it	-PRON-	PRP
10_1101-2021_01_08_423993	805	21	was	be	VBD
10_1101-2021_01_08_423993	805	22	included	include	VBN
10_1101-2021_01_08_423993	805	23	in	in	IN
10_1101-2021_01_08_423993	805	24	refinement	refinement	NN
10_1101-2021_01_08_423993	805	25	.	.	.
10_1101-2021_01_08_423993	806	1	Figure	figure	NN
10_1101-2021_01_08_423993	806	2	4	4	CD
10_1101-2021_01_08_423993	806	3	:	:	:
10_1101-2021_01_08_423993	806	4	Overall	overall	JJ
10_1101-2021_01_08_423993	806	5	structure	structure	NN
10_1101-2021_01_08_423993	806	6	representation	representation	NN
10_1101-2021_01_08_423993	806	7	of	of	IN
10_1101-2021_01_08_423993	806	8	the	the	DT
10_1101-2021_01_08_423993	806	9	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	806	10	/SNM1C	/SNM1C	:
10_1101-2021_01_08_423993	806	11	fold	fold	VB
10_1101-2021_01_08_423993	806	12	.	.	.
10_1101-2021_01_08_423993	807	1	A.	A.	NNP
10_1101-2021_01_08_423993	807	2	Overlay	Overlay	NNP
10_1101-2021_01_08_423993	807	3	of	of	IN
10_1101-2021_01_08_423993	807	4	our	-PRON-	PRP$
10_1101-2021_01_08_423993	807	5	wt	wt	NN
10_1101-2021_01_08_423993	807	6	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	807	7	structure	structure	NN
10_1101-2021_01_08_423993	807	8	(	(	-LRB-
10_1101-2021_01_08_423993	807	9	PDB	PDB	NNP
10_1101-2021_01_08_423993	807	10	code	code	NN
10_1101-2021_01_08_423993	807	11	:	:	:
10_1101-2021_01_08_423993	807	12	7AF1	7af1	LS
10_1101-2021_01_08_423993	807	13	)	)	-RRB-
10_1101-2021_01_08_423993	807	14	(	(	-LRB-
10_1101-2021_01_08_423993	807	15	pink	pink	JJ
10_1101-2021_01_08_423993	807	16	)	)	-RRB-
10_1101-2021_01_08_423993	807	17	with	with	IN
10_1101-2021_01_08_423993	807	18	that	that	DT
10_1101-2021_01_08_423993	807	19	of	of	IN
10_1101-2021_01_08_423993	807	20	Karim	Karim	NNP
10_1101-2021_01_08_423993	807	21	et	et	NNP
10_1101-2021_01_08_423993	807	22	.	.	.
10_1101-2021_01_08_423993	808	1	al	al	NNP
10_1101-2021_01_08_423993	808	2	.	.	.
10_1101-2021_01_08_423993	809	1	PDB	PDB	NNP
10_1101-2021_01_08_423993	809	2	code	code	NN
10_1101-2021_01_08_423993	809	3	:	:	:
10_1101-2021_01_08_423993	809	4	6WO0	6wo0	CD
10_1101-2021_01_08_423993	809	5	(	(	-LRB-
10_1101-2021_01_08_423993	809	6	aquamarine	aquamarine	NN
10_1101-2021_01_08_423993	809	7	)	)	-RRB-
10_1101-2021_01_08_423993	809	8	(	(	-LRB-
10_1101-2021_01_08_423993	809	9	backbone	backbone	NN
10_1101-2021_01_08_423993	809	10	RMSD	RMSD	NNP
10_1101-2021_01_08_423993	809	11	0.48	0.48	CD
10_1101-2021_01_08_423993	809	12	Å	Å	NNP
10_1101-2021_01_08_423993	809	13	)	)	-RRB-
10_1101-2021_01_08_423993	809	14	.	.	.
10_1101-2021_01_08_423993	810	1	B.	B.	NNP
10_1101-2021_01_08_423993	811	1	.CC	.CC	NFP
10_1101-2021_01_08_423993	811	2	-	-	:
10_1101-2021_01_08_423993	811	3	BY	by	IN
10_1101-2021_01_08_423993	811	4	4.0	4.0	CD
10_1101-2021_01_08_423993	811	5	International	international	JJ
10_1101-2021_01_08_423993	811	6	licensemade	licensemade	NN
10_1101-2021_01_08_423993	811	7	available	available	JJ
10_1101-2021_01_08_423993	811	8	under	under	IN
10_1101-2021_01_08_423993	811	9	a	a	DT
10_1101-2021_01_08_423993	811	10	(	(	-LRB-
10_1101-2021_01_08_423993	811	11	which	which	WDT
10_1101-2021_01_08_423993	811	12	was	be	VBD
10_1101-2021_01_08_423993	811	13	not	not	RB
10_1101-2021_01_08_423993	811	14	certified	certify	VBN
10_1101-2021_01_08_423993	811	15	by	by	IN
10_1101-2021_01_08_423993	811	16	peer	peer	NN
10_1101-2021_01_08_423993	811	17	review	review	NN
10_1101-2021_01_08_423993	811	18	)	)	-RRB-
10_1101-2021_01_08_423993	811	19	is	be	VBZ
10_1101-2021_01_08_423993	811	20	the	the	DT
10_1101-2021_01_08_423993	811	21	author	author	NN
10_1101-2021_01_08_423993	811	22	/	/	SYM
10_1101-2021_01_08_423993	811	23	funder	funder	NN
10_1101-2021_01_08_423993	811	24	,	,	,
10_1101-2021_01_08_423993	811	25	who	who	WP
10_1101-2021_01_08_423993	811	26	has	have	VBZ
10_1101-2021_01_08_423993	811	27	granted	grant	VBN
10_1101-2021_01_08_423993	811	28	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	811	29	a	a	DT
10_1101-2021_01_08_423993	811	30	license	license	NN
10_1101-2021_01_08_423993	811	31	to	to	TO
10_1101-2021_01_08_423993	811	32	display	display	VB
10_1101-2021_01_08_423993	811	33	the	the	DT
10_1101-2021_01_08_423993	811	34	preprint	preprint	NN
10_1101-2021_01_08_423993	811	35	in	in	IN
10_1101-2021_01_08_423993	811	36	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	811	37	.	.	.
10_1101-2021_01_08_423993	812	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	812	2	is	be	VBZ
10_1101-2021_01_08_423993	812	3	The	the	DT
10_1101-2021_01_08_423993	812	4	copyright	copyright	NN
10_1101-2021_01_08_423993	812	5	holder	holder	NN
10_1101-2021_01_08_423993	812	6	for	for	IN
10_1101-2021_01_08_423993	812	7	this	this	DT
10_1101-2021_01_08_423993	812	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	812	9	version	version	NN
10_1101-2021_01_08_423993	812	10	posted	post	VBD
10_1101-2021_01_08_423993	812	11	January	January	NNP
10_1101-2021_01_08_423993	812	12	8	8	CD
10_1101-2021_01_08_423993	812	13	,	,	,
10_1101-2021_01_08_423993	812	14	2021	2021	CD
10_1101-2021_01_08_423993	812	15	.	.	.
10_1101-2021_01_08_423993	812	16	;	;	:
10_1101-2021_01_08_423993	812	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	812	18	:	:	:
10_1101-2021_01_08_423993	812	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	812	20	preprint	preprint	NN
10_1101-2021_01_08_423993	812	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	812	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	812	23	Re	re	NN
10_1101-2021_01_08_423993	812	24	-	-	NN
10_1101-2021_01_08_423993	812	25	analysis	analysis	NN
10_1101-2021_01_08_423993	812	26	of	of	IN
10_1101-2021_01_08_423993	812	27	the	the	DT
10_1101-2021_01_08_423993	812	28	latter	latter	JJ
10_1101-2021_01_08_423993	812	29	(	(	-LRB-
10_1101-2021_01_08_423993	812	30	6WO0	6wo0	SYM
10_1101-2021_01_08_423993	812	31	)	)	-RRB-
10_1101-2021_01_08_423993	812	32	structure	structure	NN
10_1101-2021_01_08_423993	812	33	re	re	NN
10_1101-2021_01_08_423993	812	34	-	-	VBN
10_1101-2021_01_08_423993	812	35	refined	refine	VBN
10_1101-2021_01_08_423993	812	36	with	with	IN
10_1101-2021_01_08_423993	812	37	a	a	DT
10_1101-2021_01_08_423993	812	38	DNA	dna	NN
10_1101-2021_01_08_423993	812	39	molecule	molecule	NN
10_1101-2021_01_08_423993	812	40	present	present	JJ
10_1101-2021_01_08_423993	812	41	(	(	-LRB-
10_1101-2021_01_08_423993	812	42	PDB	PDB	NNP
10_1101-2021_01_08_423993	812	43	code	code	NN
10_1101-2021_01_08_423993	812	44	;	;	:
10_1101-2021_01_08_423993	812	45	7ABS	7ABS	NNP
10_1101-2021_01_08_423993	812	46	)	)	-RRB-
10_1101-2021_01_08_423993	812	47	.	.	.
10_1101-2021_01_08_423993	813	1	The	the	DT
10_1101-2021_01_08_423993	813	2	2Fo-	2fo-	JJ
10_1101-2021_01_08_423993	813	3	Fc	Fc	NNP
10_1101-2021_01_08_423993	813	4	map	map	NN
10_1101-2021_01_08_423993	813	5	(	(	-LRB-
10_1101-2021_01_08_423993	813	6	contoured	contour	VBN
10_1101-2021_01_08_423993	813	7	at	at	IN
10_1101-2021_01_08_423993	813	8	0.6σ	0.6σ	NNP
10_1101-2021_01_08_423993	813	9	in	in	IN
10_1101-2021_01_08_423993	813	10	pymol	pymol	NNP
10_1101-2021_01_08_423993	813	11	)	)	-RRB-
10_1101-2021_01_08_423993	813	12	is	be	VBZ
10_1101-2021_01_08_423993	813	13	represented	represent	VBN
10_1101-2021_01_08_423993	813	14	by	by	IN
10_1101-2021_01_08_423993	813	15	grey	grey	NNP
10_1101-2021_01_08_423993	813	16	mesh	mesh	NNP
10_1101-2021_01_08_423993	813	17	surrounding	surround	VBG
10_1101-2021_01_08_423993	813	18	the	the	DT
10_1101-2021_01_08_423993	813	19	DNA	DNA	NNP
10_1101-2021_01_08_423993	813	20	(	(	-LRB-
10_1101-2021_01_08_423993	813	21	yellow	yellow	NN
10_1101-2021_01_08_423993	813	22	)	)	-RRB-
10_1101-2021_01_08_423993	813	23	.	.	.
10_1101-2021_01_08_423993	814	1	Figure	figure	NN
10_1101-2021_01_08_423993	814	2	5	5	CD
10_1101-2021_01_08_423993	814	3	:	:	:
10_1101-2021_01_08_423993	814	4	Electrostatic	electrostatic	JJ
10_1101-2021_01_08_423993	814	5	surface	surface	NN
10_1101-2021_01_08_423993	814	6	potentials	potential	NNS
10_1101-2021_01_08_423993	814	7	of	of	IN
10_1101-2021_01_08_423993	814	8	DNA	dna	NN
10_1101-2021_01_08_423993	814	9	bound	bind	VBN
10_1101-2021_01_08_423993	814	10	model	model	NN
10_1101-2021_01_08_423993	814	11	for	for	IN
10_1101-2021_01_08_423993	814	12	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	814	13	/	/	SYM
10_1101-2021_01_08_423993	814	14	SNM1C	snm1c	NN
10_1101-2021_01_08_423993	814	15	(	(	-LRB-
10_1101-2021_01_08_423993	814	16	A	a	NN
10_1101-2021_01_08_423993	814	17	)	)	-RRB-
10_1101-2021_01_08_423993	814	18	and	and	CC
10_1101-2021_01_08_423993	814	19	Apollo	Apollo	NNP
10_1101-2021_01_08_423993	814	20	/	/	SYM
10_1101-2021_01_08_423993	814	21	SNM1B	snm1b	FW
10_1101-2021_01_08_423993	814	22	(	(	-LRB-
10_1101-2021_01_08_423993	814	23	B	b	NN
10_1101-2021_01_08_423993	814	24	)	)	-RRB-
10_1101-2021_01_08_423993	814	25	.	.	.
10_1101-2021_01_08_423993	815	1	The	the	DT
10_1101-2021_01_08_423993	815	2	blue	blue	JJ
10_1101-2021_01_08_423993	815	3	colour	colour	NN
10_1101-2021_01_08_423993	815	4	represents	represent	VBZ
10_1101-2021_01_08_423993	815	5	a	a	DT
10_1101-2021_01_08_423993	815	6	more	more	RBR
10_1101-2021_01_08_423993	815	7	electropositive	electropositive	JJ
10_1101-2021_01_08_423993	815	8	surface	surface	NN
10_1101-2021_01_08_423993	815	9	potential	potential	NN
10_1101-2021_01_08_423993	815	10	and	and	CC
10_1101-2021_01_08_423993	815	11	the	the	DT
10_1101-2021_01_08_423993	815	12	red	red	JJ
10_1101-2021_01_08_423993	815	13	show	show	VBP
10_1101-2021_01_08_423993	815	14	a	a	DT
10_1101-2021_01_08_423993	815	15	more	more	RBR
10_1101-2021_01_08_423993	815	16	electronegative	electronegative	JJ
10_1101-2021_01_08_423993	815	17	cluster	cluster	NN
10_1101-2021_01_08_423993	815	18	.	.	.
10_1101-2021_01_08_423993	816	1	The	the	DT
10_1101-2021_01_08_423993	816	2	active	active	JJ
10_1101-2021_01_08_423993	816	3	site	site	NN
10_1101-2021_01_08_423993	816	4	contains	contain	VBZ
10_1101-2021_01_08_423993	816	5	the	the	DT
10_1101-2021_01_08_423993	816	6	two	two	CD
10_1101-2021_01_08_423993	816	7	metal	metal	NN
10_1101-2021_01_08_423993	816	8	ions	ion	NNS
10_1101-2021_01_08_423993	816	9	represented	represent	VBN
10_1101-2021_01_08_423993	816	10	in	in	IN
10_1101-2021_01_08_423993	816	11	grey	grey	NN
10_1101-2021_01_08_423993	816	12	sphere	sphere	NN
10_1101-2021_01_08_423993	816	13	for	for	IN
10_1101-2021_01_08_423993	816	14	Zinc	Zinc	NNP
10_1101-2021_01_08_423993	816	15	,	,	,
10_1101-2021_01_08_423993	816	16	orange	orange	UH
10_1101-2021_01_08_423993	816	17	sphere	sphere	RB
10_1101-2021_01_08_423993	816	18	for	for	IN
10_1101-2021_01_08_423993	816	19	Iron	Iron	NNP
10_1101-2021_01_08_423993	816	20	and	and	CC
10_1101-2021_01_08_423993	816	21	green	green	JJ
10_1101-2021_01_08_423993	816	22	sphere	sphere	NN
10_1101-2021_01_08_423993	816	23	for	for	IN
10_1101-2021_01_08_423993	816	24	Nickel	Nickel	NNP
10_1101-2021_01_08_423993	816	25	ion	ion	NN
10_1101-2021_01_08_423993	816	26	.	.	.
10_1101-2021_01_08_423993	817	1	N-	n-	CD
10_1101-2021_01_08_423993	817	2	and	and	CC
10_1101-2021_01_08_423993	817	3	C-	c-	NN
10_1101-2021_01_08_423993	817	4	terminal	terminal	NN
10_1101-2021_01_08_423993	817	5	of	of	IN
10_1101-2021_01_08_423993	817	6	the	the	DT
10_1101-2021_01_08_423993	817	7	protein	protein	NN
10_1101-2021_01_08_423993	817	8	are	be	VBP
10_1101-2021_01_08_423993	817	9	indicated	indicate	VBN
10_1101-2021_01_08_423993	817	10	in	in	IN
10_1101-2021_01_08_423993	817	11	red	red	NN
10_1101-2021_01_08_423993	817	12	.	.	.
10_1101-2021_01_08_423993	818	1	The	the	DT
10_1101-2021_01_08_423993	818	2	electrostatic	electrostatic	JJ
10_1101-2021_01_08_423993	818	3	surface	surface	NN
10_1101-2021_01_08_423993	818	4	potentials	potential	NNS
10_1101-2021_01_08_423993	818	5	were	be	VBD
10_1101-2021_01_08_423993	818	6	generated	generate	VBN
10_1101-2021_01_08_423993	818	7	using	use	VBG
10_1101-2021_01_08_423993	818	8	PyMOL	PyMOL	NNP
10_1101-2021_01_08_423993	818	9	(	(	-LRB-
10_1101-2021_01_08_423993	818	10	electrostatic	electrostatic	JJ
10_1101-2021_01_08_423993	818	11	range	range	NN
10_1101-2021_01_08_423993	818	12	at	at	IN
10_1101-2021_01_08_423993	818	13	+	+	RB
10_1101-2021_01_08_423993	818	14	/-	/-	.
10_1101-2021_01_08_423993	818	15	5	5	CD
10_1101-2021_01_08_423993	818	16	)	)	-RRB-
10_1101-2021_01_08_423993	818	17	.	.	.
10_1101-2021_01_08_423993	819	1	.CC	.CC	NFP
10_1101-2021_01_08_423993	819	2	-	-	:
10_1101-2021_01_08_423993	819	3	BY	by	IN
10_1101-2021_01_08_423993	819	4	4.0	4.0	CD
10_1101-2021_01_08_423993	819	5	International	international	JJ
10_1101-2021_01_08_423993	819	6	licensemade	licensemade	NN
10_1101-2021_01_08_423993	819	7	available	available	JJ
10_1101-2021_01_08_423993	819	8	under	under	IN
10_1101-2021_01_08_423993	819	9	a	a	DT
10_1101-2021_01_08_423993	819	10	(	(	-LRB-
10_1101-2021_01_08_423993	819	11	which	which	WDT
10_1101-2021_01_08_423993	819	12	was	be	VBD
10_1101-2021_01_08_423993	819	13	not	not	RB
10_1101-2021_01_08_423993	819	14	certified	certify	VBN
10_1101-2021_01_08_423993	819	15	by	by	IN
10_1101-2021_01_08_423993	819	16	peer	peer	NN
10_1101-2021_01_08_423993	819	17	review	review	NN
10_1101-2021_01_08_423993	819	18	)	)	-RRB-
10_1101-2021_01_08_423993	819	19	is	be	VBZ
10_1101-2021_01_08_423993	819	20	the	the	DT
10_1101-2021_01_08_423993	819	21	author	author	NN
10_1101-2021_01_08_423993	819	22	/	/	SYM
10_1101-2021_01_08_423993	819	23	funder	funder	NN
10_1101-2021_01_08_423993	819	24	,	,	,
10_1101-2021_01_08_423993	819	25	who	who	WP
10_1101-2021_01_08_423993	819	26	has	have	VBZ
10_1101-2021_01_08_423993	819	27	granted	grant	VBN
10_1101-2021_01_08_423993	819	28	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	819	29	a	a	DT
10_1101-2021_01_08_423993	819	30	license	license	NN
10_1101-2021_01_08_423993	819	31	to	to	TO
10_1101-2021_01_08_423993	819	32	display	display	VB
10_1101-2021_01_08_423993	819	33	the	the	DT
10_1101-2021_01_08_423993	819	34	preprint	preprint	NN
10_1101-2021_01_08_423993	819	35	in	in	IN
10_1101-2021_01_08_423993	819	36	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	819	37	.	.	.
10_1101-2021_01_08_423993	820	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	820	2	is	be	VBZ
10_1101-2021_01_08_423993	820	3	The	the	DT
10_1101-2021_01_08_423993	820	4	copyright	copyright	NN
10_1101-2021_01_08_423993	820	5	holder	holder	NN
10_1101-2021_01_08_423993	820	6	for	for	IN
10_1101-2021_01_08_423993	820	7	this	this	DT
10_1101-2021_01_08_423993	820	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	820	9	version	version	NN
10_1101-2021_01_08_423993	820	10	posted	post	VBD
10_1101-2021_01_08_423993	820	11	January	January	NNP
10_1101-2021_01_08_423993	820	12	8	8	CD
10_1101-2021_01_08_423993	820	13	,	,	,
10_1101-2021_01_08_423993	820	14	2021	2021	CD
10_1101-2021_01_08_423993	820	15	.	.	.
10_1101-2021_01_08_423993	820	16	;	;	:
10_1101-2021_01_08_423993	820	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	820	18	:	:	:
10_1101-2021_01_08_423993	820	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	820	20	preprint	preprint	NN
10_1101-2021_01_08_423993	820	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	CD
10_1101-2021_01_08_423993	820	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	820	23	Figure	Figure	NNP
10_1101-2021_01_08_423993	820	24	6	6	CD
10_1101-2021_01_08_423993	820	25	:	:	:
10_1101-2021_01_08_423993	820	26	Proposed	propose	VBN
10_1101-2021_01_08_423993	820	27	interactions	interaction	NNS
10_1101-2021_01_08_423993	820	28	of	of	IN
10_1101-2021_01_08_423993	820	29	DNA	dna	NN
10_1101-2021_01_08_423993	820	30	with	with	IN
10_1101-2021_01_08_423993	820	31	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	820	32	(	(	-LRB-
10_1101-2021_01_08_423993	820	33	PDB	PDB	NNP
10_1101-2021_01_08_423993	820	34	:	:	:
10_1101-2021_01_08_423993	820	35	7ABS	7ABS	NNP
10_1101-2021_01_08_423993	820	36	)	)	-RRB-
10_1101-2021_01_08_423993	820	37	.	.	.
10_1101-2021_01_08_423993	821	1	Model	model	NN
10_1101-2021_01_08_423993	821	2	for	for	IN
10_1101-2021_01_08_423993	821	3	DNA	dna	NN
10_1101-2021_01_08_423993	821	4	binding	bind	VBG
10_1101-2021_01_08_423993	821	5	to	to	IN
10_1101-2021_01_08_423993	821	6	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	821	7	showing	show	VBG
10_1101-2021_01_08_423993	821	8	the	the	DT
10_1101-2021_01_08_423993	821	9	residues	residue	NNS
10_1101-2021_01_08_423993	821	10	contacting	contact	VBG
10_1101-2021_01_08_423993	821	11	DNA	dna	NN
10_1101-2021_01_08_423993	821	12	.	.	.
10_1101-2021_01_08_423993	822	1	The	the	DT
10_1101-2021_01_08_423993	822	2	two	two	CD
10_1101-2021_01_08_423993	822	3	zinc	zinc	NN
10_1101-2021_01_08_423993	822	4	ions	ion	NNS
10_1101-2021_01_08_423993	822	5	at	at	IN
10_1101-2021_01_08_423993	822	6	the	the	DT
10_1101-2021_01_08_423993	822	7	active	active	JJ
10_1101-2021_01_08_423993	822	8	site	site	NN
10_1101-2021_01_08_423993	822	9	are	be	VBP
10_1101-2021_01_08_423993	822	10	represented	represent	VBN
10_1101-2021_01_08_423993	822	11	by	by	IN
10_1101-2021_01_08_423993	822	12	grey	grey	JJ
10_1101-2021_01_08_423993	822	13	spheres	sphere	NNS
10_1101-2021_01_08_423993	822	14	.	.	.
10_1101-2021_01_08_423993	823	1	A.	A.	NNP
10_1101-2021_01_08_423993	824	1	A	a	DT
10_1101-2021_01_08_423993	824	2	row	row	NN
10_1101-2021_01_08_423993	824	3	of	of	IN
10_1101-2021_01_08_423993	824	4	positively	positively	RB
10_1101-2021_01_08_423993	824	5	charged	charge	VBN
10_1101-2021_01_08_423993	824	6	residue	residue	NN
10_1101-2021_01_08_423993	824	7	is	be	VBZ
10_1101-2021_01_08_423993	824	8	on	on	IN
10_1101-2021_01_08_423993	824	9	the	the	DT
10_1101-2021_01_08_423993	824	10	surface	surface	NN
10_1101-2021_01_08_423993	824	11	of	of	IN
10_1101-2021_01_08_423993	824	12	the	the	DT
10_1101-2021_01_08_423993	824	13	MBL	MBL	NNP
10_1101-2021_01_08_423993	824	14	domain	domain	NN
10_1101-2021_01_08_423993	824	15	interact	interact	NN
10_1101-2021_01_08_423993	824	16	with	with	IN
10_1101-2021_01_08_423993	824	17	the	the	DT
10_1101-2021_01_08_423993	824	18	phosphate	phosphate	JJ
10_1101-2021_01_08_423993	824	19	backbone	backbone	NN
10_1101-2021_01_08_423993	824	20	of	of	IN
10_1101-2021_01_08_423993	824	21	the	the	DT
10_1101-2021_01_08_423993	824	22	DNA	DNA	NNP
10_1101-2021_01_08_423993	824	23	.	.	.
10_1101-2021_01_08_423993	825	1	B.	B.	NNP
10_1101-2021_01_08_423993	826	1	A	a	DT
10_1101-2021_01_08_423993	826	2	DNA	dna	NN
10_1101-2021_01_08_423993	826	3	overhang	overhang	NN
10_1101-2021_01_08_423993	826	4	is	be	VBZ
10_1101-2021_01_08_423993	826	5	located	locate	VBN
10_1101-2021_01_08_423993	826	6	at	at	IN
10_1101-2021_01_08_423993	826	7	the	the	DT
10_1101-2021_01_08_423993	826	8	active	active	JJ
10_1101-2021_01_08_423993	826	9	site	site	NN
10_1101-2021_01_08_423993	826	10	.	.	.
10_1101-2021_01_08_423993	827	1	A	a	DT
10_1101-2021_01_08_423993	827	2	cluster	cluster	NN
10_1101-2021_01_08_423993	827	3	of	of	IN
10_1101-2021_01_08_423993	827	4	polar	polar	JJ
10_1101-2021_01_08_423993	827	5	residues	residue	NNS
10_1101-2021_01_08_423993	827	6	(	(	-LRB-
10_1101-2021_01_08_423993	827	7	N205	N205	NNP
10_1101-2021_01_08_423993	827	8	,	,	,
10_1101-2021_01_08_423993	827	9	K207	K207	NNP
10_1101-2021_01_08_423993	827	10	and	and	CC
10_1101-2021_01_08_423993	827	11	K288	K288	NNP
10_1101-2021_01_08_423993	827	12	)	)	-RRB-
10_1101-2021_01_08_423993	827	13	is	be	VBZ
10_1101-2021_01_08_423993	827	14	located	locate	VBN
10_1101-2021_01_08_423993	827	15	in	in	IN
10_1101-2021_01_08_423993	827	16	the	the	DT
10_1101-2021_01_08_423993	827	17	β	β	NNP
10_1101-2021_01_08_423993	827	18	-	-	HYPH
10_1101-2021_01_08_423993	827	19	CASP	CASP	NNP
10_1101-2021_01_08_423993	827	20	domain	domain	NN
10_1101-2021_01_08_423993	827	21	.	.	.
10_1101-2021_01_08_423993	828	1	The	the	DT
10_1101-2021_01_08_423993	828	2	extended	extended	JJ
10_1101-2021_01_08_423993	828	3	flexible	flexible	JJ
10_1101-2021_01_08_423993	828	4	loop	loop	NN
10_1101-2021_01_08_423993	828	5	,	,	,
10_1101-2021_01_08_423993	828	6	which	which	WDT
10_1101-2021_01_08_423993	828	7	is	be	VBZ
10_1101-2021_01_08_423993	828	8	unique	unique	JJ
10_1101-2021_01_08_423993	828	9	to	to	IN
10_1101-2021_01_08_423993	828	10	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	828	11	compared	compare	VBN
10_1101-2021_01_08_423993	828	12	to	to	IN
10_1101-2021_01_08_423993	828	13	SNM1A	SNM1A	NNS
10_1101-2021_01_08_423993	828	14	and	and	CC
10_1101-2021_01_08_423993	828	15	SNM1B	snm1b	CD
10_1101-2021_01_08_423993	828	16	,	,	,
10_1101-2021_01_08_423993	828	17	that	that	WDT
10_1101-2021_01_08_423993	828	18	connects	connect	VBZ
10_1101-2021_01_08_423993	828	19	b27	b27	NN
10_1101-2021_01_08_423993	828	20	and	and	CC
10_1101-2021_01_08_423993	828	21	b28	b28	NN
10_1101-2021_01_08_423993	828	22	is	be	VBZ
10_1101-2021_01_08_423993	828	23	indicated	indicate	VBN
10_1101-2021_01_08_423993	828	24	on	on	IN
10_1101-2021_01_08_423993	828	25	the	the	DT
10_1101-2021_01_08_423993	828	26	right	right	NN
10_1101-2021_01_08_423993	828	27	.	.	.
10_1101-2021_01_08_423993	829	1	C.	C.	NNP
10_1101-2021_01_08_423993	829	2	The	the	DT
10_1101-2021_01_08_423993	829	3	DNA	DNA	NNP
10_1101-2021_01_08_423993	829	4	overhang	overhang	NN
10_1101-2021_01_08_423993	829	5	forms	form	VBZ
10_1101-2021_01_08_423993	829	6	a	a	DT
10_1101-2021_01_08_423993	829	7	hydrogen	hydrogen	NN
10_1101-2021_01_08_423993	829	8	bond	bond	NN
10_1101-2021_01_08_423993	829	9	with	with	IN
10_1101-2021_01_08_423993	829	10	Arginine	Arginine	NNP
10_1101-2021_01_08_423993	829	11	172	172	CD
10_1101-2021_01_08_423993	829	12	and	and	CC
10_1101-2021_01_08_423993	829	13	interacts	interact	VBZ
10_1101-2021_01_08_423993	829	14	with	with	IN
10_1101-2021_01_08_423993	829	15	a	a	DT
10_1101-2021_01_08_423993	829	16	cluster	cluster	NN
10_1101-2021_01_08_423993	829	17	of	of	IN
10_1101-2021_01_08_423993	829	18	hydrophobic	hydrophobic	JJ
10_1101-2021_01_08_423993	829	19	residues	residue	NNS
10_1101-2021_01_08_423993	829	20	at	at	IN
10_1101-2021_01_08_423993	829	21	the	the	DT
10_1101-2021_01_08_423993	829	22	interface	interface	NN
10_1101-2021_01_08_423993	829	23	between	between	IN
10_1101-2021_01_08_423993	829	24	MBL	MBL	NNP
10_1101-2021_01_08_423993	829	25	and	and	CC
10_1101-2021_01_08_423993	829	26	β	β	NNP
10_1101-2021_01_08_423993	829	27	-	-	HYPH
10_1101-2021_01_08_423993	829	28	CASP	CASP	NNP
10_1101-2021_01_08_423993	829	29	domains	domain	NNS
10_1101-2021_01_08_423993	829	30	.	.	.
10_1101-2021_01_08_423993	830	1	.CC	.CC	NFP
10_1101-2021_01_08_423993	830	2	-	-	:
10_1101-2021_01_08_423993	830	3	BY	by	IN
10_1101-2021_01_08_423993	830	4	4.0	4.0	CD
10_1101-2021_01_08_423993	830	5	International	international	JJ
10_1101-2021_01_08_423993	830	6	licensemade	licensemade	NN
10_1101-2021_01_08_423993	830	7	available	available	JJ
10_1101-2021_01_08_423993	830	8	under	under	IN
10_1101-2021_01_08_423993	830	9	a	a	DT
10_1101-2021_01_08_423993	830	10	(	(	-LRB-
10_1101-2021_01_08_423993	830	11	which	which	WDT
10_1101-2021_01_08_423993	830	12	was	be	VBD
10_1101-2021_01_08_423993	830	13	not	not	RB
10_1101-2021_01_08_423993	830	14	certified	certify	VBN
10_1101-2021_01_08_423993	830	15	by	by	IN
10_1101-2021_01_08_423993	830	16	peer	peer	NN
10_1101-2021_01_08_423993	830	17	review	review	NN
10_1101-2021_01_08_423993	830	18	)	)	-RRB-
10_1101-2021_01_08_423993	830	19	is	be	VBZ
10_1101-2021_01_08_423993	830	20	the	the	DT
10_1101-2021_01_08_423993	830	21	author	author	NN
10_1101-2021_01_08_423993	830	22	/	/	SYM
10_1101-2021_01_08_423993	830	23	funder	funder	NN
10_1101-2021_01_08_423993	830	24	,	,	,
10_1101-2021_01_08_423993	830	25	who	who	WP
10_1101-2021_01_08_423993	830	26	has	have	VBZ
10_1101-2021_01_08_423993	830	27	granted	grant	VBN
10_1101-2021_01_08_423993	830	28	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	830	29	a	a	DT
10_1101-2021_01_08_423993	830	30	license	license	NN
10_1101-2021_01_08_423993	830	31	to	to	TO
10_1101-2021_01_08_423993	830	32	display	display	VB
10_1101-2021_01_08_423993	830	33	the	the	DT
10_1101-2021_01_08_423993	830	34	preprint	preprint	NN
10_1101-2021_01_08_423993	830	35	in	in	IN
10_1101-2021_01_08_423993	830	36	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	830	37	.	.	.
10_1101-2021_01_08_423993	831	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	831	2	is	be	VBZ
10_1101-2021_01_08_423993	831	3	The	the	DT
10_1101-2021_01_08_423993	831	4	copyright	copyright	NN
10_1101-2021_01_08_423993	831	5	holder	holder	NN
10_1101-2021_01_08_423993	831	6	for	for	IN
10_1101-2021_01_08_423993	831	7	this	this	DT
10_1101-2021_01_08_423993	831	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	831	9	version	version	NN
10_1101-2021_01_08_423993	831	10	posted	post	VBD
10_1101-2021_01_08_423993	831	11	January	January	NNP
10_1101-2021_01_08_423993	831	12	8	8	CD
10_1101-2021_01_08_423993	831	13	,	,	,
10_1101-2021_01_08_423993	831	14	2021	2021	CD
10_1101-2021_01_08_423993	831	15	.	.	.
10_1101-2021_01_08_423993	831	16	;	;	:
10_1101-2021_01_08_423993	831	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	831	18	:	:	:
10_1101-2021_01_08_423993	831	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	831	20	preprint	preprint	NN
10_1101-2021_01_08_423993	831	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	CD
10_1101-2021_01_08_423993	831	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	831	23	Figure	Figure	NNP
10_1101-2021_01_08_423993	831	24	7	7	CD
10_1101-2021_01_08_423993	831	25	:	:	:
10_1101-2021_01_08_423993	831	26	Nuclease	Nuclease	NNP
10_1101-2021_01_08_423993	831	27	assay	assay	NN
10_1101-2021_01_08_423993	831	28	utilising	utilising	NN
10_1101-2021_01_08_423993	831	29	truncated	truncate	VBN
10_1101-2021_01_08_423993	831	30	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	831	31	(	(	-LRB-
10_1101-2021_01_08_423993	831	32	aa	aa	NNP
10_1101-2021_01_08_423993	831	33	3–361	3–361	CD
10_1101-2021_01_08_423993	831	34	)	)	-RRB-
10_1101-2021_01_08_423993	831	35	with	with	IN
10_1101-2021_01_08_423993	831	36	various	various	JJ
10_1101-2021_01_08_423993	831	37	DNA	dna	NN
10_1101-2021_01_08_423993	831	38	substrates	substrate	NNS
10_1101-2021_01_08_423993	831	39	.	.	.
10_1101-2021_01_08_423993	832	1	A.	A.	NNP
10_1101-2021_01_08_423993	833	1	The	the	DT
10_1101-2021_01_08_423993	833	2	nuclease	nuclease	NN
10_1101-2021_01_08_423993	833	3	activity	activity	NN
10_1101-2021_01_08_423993	833	4	of	of	IN
10_1101-2021_01_08_423993	833	5	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	833	6	is	be	VBZ
10_1101-2021_01_08_423993	833	7	indifferent	indifferent	JJ
10_1101-2021_01_08_423993	833	8	to	to	IN
10_1101-2021_01_08_423993	833	9	the	the	DT
10_1101-2021_01_08_423993	833	10	5	5	CD
10_1101-2021_01_08_423993	833	11	’	'	''
10_1101-2021_01_08_423993	833	12	end	end	NNP
10_1101-2021_01_08_423993	833	13	group	group	NN
10_1101-2021_01_08_423993	833	14	,	,	,
10_1101-2021_01_08_423993	833	15	indicative	indicative	JJ
10_1101-2021_01_08_423993	833	16	of	of	IN
10_1101-2021_01_08_423993	833	17	true	true	JJ
10_1101-2021_01_08_423993	833	18	endonuclease	endonuclease	NN
10_1101-2021_01_08_423993	833	19	activity	activity	NN
10_1101-2021_01_08_423993	833	20	.	.	.
10_1101-2021_01_08_423993	834	1	Increasing	increase	VBG
10_1101-2021_01_08_423993	834	2	concentrations	concentration	NNS
10_1101-2021_01_08_423993	834	3	of	of	IN
10_1101-2021_01_08_423993	834	4	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	834	5	from	from	IN
10_1101-2021_01_08_423993	834	6	0	0	CD
10_1101-2021_01_08_423993	834	7	(	(	-LRB-
10_1101-2021_01_08_423993	834	8	NE	NE	NNP
10_1101-2021_01_08_423993	834	9	;	;	:
10_1101-2021_01_08_423993	834	10	no	no	DT
10_1101-2021_01_08_423993	834	11	enzyme	enzyme	NNS
10_1101-2021_01_08_423993	834	12	)	)	-RRB-
10_1101-2021_01_08_423993	834	13	to	to	IN
10_1101-2021_01_08_423993	834	14	250	250	CD
10_1101-2021_01_08_423993	834	15	nM	nM	NNP
10_1101-2021_01_08_423993	834	16	incubated	incubate	VBN
10_1101-2021_01_08_423993	834	17	with	with	IN
10_1101-2021_01_08_423993	834	18	10	10	CD
10_1101-2021_01_08_423993	834	19	nM	nM	NNP
10_1101-2021_01_08_423993	834	20	ssDNA	ssdna	NN
10_1101-2021_01_08_423993	834	21	with	with	IN
10_1101-2021_01_08_423993	834	22	either	either	CC
10_1101-2021_01_08_423993	834	23	a	a	DT
10_1101-2021_01_08_423993	834	24	5	5	CD
10_1101-2021_01_08_423993	834	25	phosphate	phosphate	NN
10_1101-2021_01_08_423993	834	26	,	,	,
10_1101-2021_01_08_423993	834	27	5	5	CD
10_1101-2021_01_08_423993	834	28	hydroxyl	hydroxyl	NN
10_1101-2021_01_08_423993	834	29	,	,	,
10_1101-2021_01_08_423993	834	30	or	or	CC
10_1101-2021_01_08_423993	834	31	5	5	CD
10_1101-2021_01_08_423993	834	32	biotin	biotin	JJ
10_1101-2021_01_08_423993	834	33	moiety	moiety	NN
10_1101-2021_01_08_423993	834	34	for	for	IN
10_1101-2021_01_08_423993	834	35	45	45	CD
10_1101-2021_01_08_423993	834	36	min	min	NN
10_1101-2021_01_08_423993	834	37	at	at	IN
10_1101-2021_01_08_423993	834	38	37	37	CD
10_1101-2021_01_08_423993	834	39	°	°	NNS
10_1101-2021_01_08_423993	834	40	C	C	NNP
10_1101-2021_01_08_423993	834	41	.	.	.
10_1101-2021_01_08_423993	835	1	B.	B.	NNP
10_1101-2021_01_08_423993	835	2	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	835	3	is	be	VBZ
10_1101-2021_01_08_423993	835	4	able	able	JJ
10_1101-2021_01_08_423993	835	5	to	to	TO
10_1101-2021_01_08_423993	835	6	cleave	cleave	VB
10_1101-2021_01_08_423993	835	7	DNA	DNA	NNP
10_1101-2021_01_08_423993	835	8	substrates	substrate	NNS
10_1101-2021_01_08_423993	835	9	containing	contain	VBG
10_1101-2021_01_08_423993	835	10	single	single	JJ
10_1101-2021_01_08_423993	835	11	-	-	HYPH
10_1101-2021_01_08_423993	835	12	stranded	strand	VBN
10_1101-2021_01_08_423993	835	13	regions	region	NNS
10_1101-2021_01_08_423993	835	14	.	.	.
10_1101-2021_01_08_423993	836	1	Increasing	increase	VBG
10_1101-2021_01_08_423993	836	2	amounts	amount	NNS
10_1101-2021_01_08_423993	836	3	of	of	IN
10_1101-2021_01_08_423993	836	4	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	836	5	incubated	incubate	VBD
10_1101-2021_01_08_423993	836	6	with	with	IN
10_1101-2021_01_08_423993	836	7	structurally	structurally	RB
10_1101-2021_01_08_423993	836	8	diverse	diverse	JJ
10_1101-2021_01_08_423993	836	9	DNA	dna	NN
10_1101-2021_01_08_423993	836	10	substrates	substrate	NNS
10_1101-2021_01_08_423993	836	11	(	(	-LRB-
10_1101-2021_01_08_423993	836	12	10	10	CD
10_1101-2021_01_08_423993	836	13	nM	nM	NNP
10_1101-2021_01_08_423993	836	14	)	)	-RRB-
10_1101-2021_01_08_423993	836	15	for	for	IN
10_1101-2021_01_08_423993	836	16	45	45	CD
10_1101-2021_01_08_423993	836	17	min	min	NN
10_1101-2021_01_08_423993	836	18	at	at	IN
10_1101-2021_01_08_423993	836	19	37oC.	37oc.	CD
10_1101-2021_01_08_423993	837	1	Products	product	NNS
10_1101-2021_01_08_423993	837	2	for	for	IN
10_1101-2021_01_08_423993	837	3	A	a	NN
10_1101-2021_01_08_423993	837	4	and	and	CC
10_1101-2021_01_08_423993	837	5	B	B	NNP
10_1101-2021_01_08_423993	837	6	were	be	VBD
10_1101-2021_01_08_423993	837	7	analysed	analyse	VBN
10_1101-2021_01_08_423993	837	8	by	by	IN
10_1101-2021_01_08_423993	837	9	20	20	CD
10_1101-2021_01_08_423993	837	10	%	%	NN
10_1101-2021_01_08_423993	837	11	denaturing	denature	VBG
10_1101-2021_01_08_423993	837	12	PAGE	PAGE	NNP
10_1101-2021_01_08_423993	837	13	.	.	.
10_1101-2021_01_08_423993	838	1	The	the	DT
10_1101-2021_01_08_423993	838	2	DNA	dna	NN
10_1101-2021_01_08_423993	838	3	substrates	substrate	NNS
10_1101-2021_01_08_423993	838	4	utilised	utilise	VBN
10_1101-2021_01_08_423993	838	5	are	be	VBP
10_1101-2021_01_08_423993	838	6	represented	represent	VBN
10_1101-2021_01_08_423993	838	7	at	at	IN
10_1101-2021_01_08_423993	838	8	the	the	DT
10_1101-2021_01_08_423993	838	9	top	top	NN
10_1101-2021_01_08_423993	838	10	of	of	IN
10_1101-2021_01_08_423993	838	11	the	the	DT
10_1101-2021_01_08_423993	838	12	lanes	lane	NNS
10_1101-2021_01_08_423993	838	13	and	and	CC
10_1101-2021_01_08_423993	838	14	a	a	DT
10_1101-2021_01_08_423993	838	15	red	red	JJ
10_1101-2021_01_08_423993	838	16	asterisk	asterisk	NN
10_1101-2021_01_08_423993	838	17	indicates	indicate	VBZ
10_1101-2021_01_08_423993	838	18	the	the	DT
10_1101-2021_01_08_423993	838	19	position	position	NN
10_1101-2021_01_08_423993	838	20	of	of	IN
10_1101-2021_01_08_423993	838	21	the	the	DT
10_1101-2021_01_08_423993	838	22	3	3	CD
10_1101-2021_01_08_423993	838	23	radiolabel	radiolabel	NN
10_1101-2021_01_08_423993	838	24	.	.	.
10_1101-2021_01_08_423993	839	1	The	the	DT
10_1101-2021_01_08_423993	839	2	positions	position	NNS
10_1101-2021_01_08_423993	839	3	of	of	IN
10_1101-2021_01_08_423993	839	4	DNA	dna	NN
10_1101-2021_01_08_423993	839	5	size	size	NN
10_1101-2021_01_08_423993	839	6	markers	marker	NNS
10_1101-2021_01_08_423993	839	7	run	run	VBP
10_1101-2021_01_08_423993	839	8	as	as	IN
10_1101-2021_01_08_423993	839	9	a	a	DT
10_1101-2021_01_08_423993	839	10	reference	reference	NN
10_1101-2021_01_08_423993	839	11	are	be	VBP
10_1101-2021_01_08_423993	839	12	indicated	indicate	VBN
10_1101-2021_01_08_423993	839	13	on	on	IN
10_1101-2021_01_08_423993	839	14	the	the	DT
10_1101-2021_01_08_423993	839	15	left	left	NN
10_1101-2021_01_08_423993	839	16	,	,	,
10_1101-2021_01_08_423993	839	17	with	with	IN
10_1101-2021_01_08_423993	839	18	sizes	size	NNS
10_1101-2021_01_08_423993	839	19	in	in	RP
10_1101-2021_01_08_423993	839	20	nt	nt	RB
10_1101-2021_01_08_423993	839	21	.	.	.
10_1101-2021_01_08_423993	840	1	NE	NE	NNP
10_1101-2021_01_08_423993	840	2	10	10	CD
10_1101-2021_01_08_423993	840	3	50	50	CD
10_1101-2021_01_08_423993	840	4	100	100	CD
10_1101-2021_01_08_423993	840	5	250	250	CD
10_1101-2021_01_08_423993	840	6	NE	NE	NNP
10_1101-2021_01_08_423993	840	7	10	10	CD
10_1101-2021_01_08_423993	840	8	50	50	CD
10_1101-2021_01_08_423993	840	9	100	100	CD
10_1101-2021_01_08_423993	840	10	250	250	CD
10_1101-2021_01_08_423993	840	11	NE	NE	NNP
10_1101-2021_01_08_423993	840	12	10	10	CD
10_1101-2021_01_08_423993	840	13	50	50	CD
10_1101-2021_01_08_423993	840	14	100	100	CD
10_1101-2021_01_08_423993	840	15	250	250	CD
10_1101-2021_01_08_423993	840	16	NE	NE	NNP
10_1101-2021_01_08_423993	840	17	10	10	CD
10_1101-2021_01_08_423993	840	18	50	50	CD
10_1101-2021_01_08_423993	840	19	100	100	CD
10_1101-2021_01_08_423993	840	20	250	250	CD
10_1101-2021_01_08_423993	840	21	NE	NE	NNP
10_1101-2021_01_08_423993	840	22	10	10	CD
10_1101-2021_01_08_423993	840	23	50	50	CD
10_1101-2021_01_08_423993	840	24	100	100	CD
10_1101-2021_01_08_423993	840	25	250	250	CD
10_1101-2021_01_08_423993	840	26	NE	NE	NNP
10_1101-2021_01_08_423993	840	27	10	10	CD
10_1101-2021_01_08_423993	840	28	50	50	CD
10_1101-2021_01_08_423993	840	29	100	100	CD
10_1101-2021_01_08_423993	840	30	250	250	CD
10_1101-2021_01_08_423993	840	31	NE	NE	NNP
10_1101-2021_01_08_423993	840	32	10	10	CD
10_1101-2021_01_08_423993	840	33	50	50	CD
10_1101-2021_01_08_423993	840	34	100	100	CD
10_1101-2021_01_08_423993	840	35	250	250	CD
10_1101-2021_01_08_423993	840	36	NE	NE	NNP
10_1101-2021_01_08_423993	840	37	10	10	CD
10_1101-2021_01_08_423993	840	38	50	50	CD
10_1101-2021_01_08_423993	840	39	100	100	CD
10_1101-2021_01_08_423993	840	40	250	250	CD
10_1101-2021_01_08_423993	840	41	ssDNA	ssdna	NN
10_1101-2021_01_08_423993	840	42	[	[	-LRB-
10_1101-2021_01_08_423993	840	43	SNM1C	snm1c	NN
10_1101-2021_01_08_423993	840	44	]	]	-RRB-
10_1101-2021_01_08_423993	840	45	(	(	-LRB-
10_1101-2021_01_08_423993	840	46	nM	nM	NNP
10_1101-2021_01_08_423993	840	47	)	)	-RRB-
10_1101-2021_01_08_423993	840	48	dsDNA	dsdna	ADD
10_1101-2021_01_08_423993	840	49	5	5	CD
10_1101-2021_01_08_423993	840	50	’	'	''
10_1101-2021_01_08_423993	840	51	overhang	overhang	NN
10_1101-2021_01_08_423993	840	52	3	3	CD
10_1101-2021_01_08_423993	840	53	’	'	''
10_1101-2021_01_08_423993	840	54	overhang	overhang	NN
10_1101-2021_01_08_423993	840	55	splayed	splayed	JJ
10_1101-2021_01_08_423993	840	56	arms	arm	NNS
10_1101-2021_01_08_423993	840	57	leading	lead	VBG
10_1101-2021_01_08_423993	840	58	flap	flap	NN
10_1101-2021_01_08_423993	840	59	lagging	lag	VBG
10_1101-2021_01_08_423993	840	60	flap	flap	NNP
10_1101-2021_01_08_423993	840	61	replication	replication	NNP
10_1101-2021_01_08_423993	840	62	fork	fork	NNP
10_1101-2021_01_08_423993	840	63	51	51	CD
10_1101-2021_01_08_423993	840	64	–	–	:
10_1101-2021_01_08_423993	840	65	41	41	CD
10_1101-2021_01_08_423993	840	66	–	–	SYM
10_1101-2021_01_08_423993	840	67	31	31	CD
10_1101-2021_01_08_423993	840	68	–	–	:
10_1101-2021_01_08_423993	840	69	26	26	CD
10_1101-2021_01_08_423993	840	70	–	–	:
10_1101-2021_01_08_423993	840	71	21	21	CD
10_1101-2021_01_08_423993	840	72	–	–	:
10_1101-2021_01_08_423993	840	73	digestion	digestion	NN
10_1101-2021_01_08_423993	840	74	products	product	NNS
10_1101-2021_01_08_423993	840	75	[	[	-LRB-
10_1101-2021_01_08_423993	840	76	SNM1C	snm1c	NN
10_1101-2021_01_08_423993	840	77	]	]	-RRB-
10_1101-2021_01_08_423993	840	78	(	(	-LRB-
10_1101-2021_01_08_423993	840	79	nM	nM	NNP
10_1101-2021_01_08_423993	840	80	)	)	-RRB-
10_1101-2021_01_08_423993	840	81	51	51	CD
10_1101-2021_01_08_423993	840	82	–	–	:
10_1101-2021_01_08_423993	840	83	41	41	CD
10_1101-2021_01_08_423993	840	84	–	–	SYM
10_1101-2021_01_08_423993	840	85	31	31	CD
10_1101-2021_01_08_423993	840	86	–	–	:
10_1101-2021_01_08_423993	840	87	26	26	CD
10_1101-2021_01_08_423993	840	88	–	–	:
10_1101-2021_01_08_423993	840	89	21	21	CD
10_1101-2021_01_08_423993	840	90	–	–	:
10_1101-2021_01_08_423993	840	91	digestion	digestion	NN
10_1101-2021_01_08_423993	840	92	products	product	NNS
10_1101-2021_01_08_423993	840	93	NE	NE	NNP
10_1101-2021_01_08_423993	840	94	10	10	CD
10_1101-2021_01_08_423993	840	95	50	50	CD
10_1101-2021_01_08_423993	840	96	100	100	CD
10_1101-2021_01_08_423993	840	97	250	250	CD
10_1101-2021_01_08_423993	840	98	NE	NE	NNP
10_1101-2021_01_08_423993	840	99	10	10	CD
10_1101-2021_01_08_423993	840	100	50	50	CD
10_1101-2021_01_08_423993	840	101	100	100	CD
10_1101-2021_01_08_423993	840	102	250	250	CD
10_1101-2021_01_08_423993	840	103	NE	NE	NNP
10_1101-2021_01_08_423993	840	104	10	10	CD
10_1101-2021_01_08_423993	840	105	50	50	CD
10_1101-2021_01_08_423993	840	106	100	100	CD
10_1101-2021_01_08_423993	840	107	250	250	CD
10_1101-2021_01_08_423993	840	108	ssDNA	ssdna	NN
10_1101-2021_01_08_423993	840	109	NE	NE	NNP
10_1101-2021_01_08_423993	840	110	10	10	CD
10_1101-2021_01_08_423993	840	111	50	50	CD
10_1101-2021_01_08_423993	840	112	100	100	CD
10_1101-2021_01_08_423993	840	113	250	250	CD
10_1101-2021_01_08_423993	840	114	NE	NE	NNP
10_1101-2021_01_08_423993	840	115	10	10	CD
10_1101-2021_01_08_423993	840	116	50	50	CD
10_1101-2021_01_08_423993	840	117	100	100	CD
10_1101-2021_01_08_423993	840	118	250	250	CD
10_1101-2021_01_08_423993	840	119	NE	NE	NNP
10_1101-2021_01_08_423993	840	120	10	10	CD
10_1101-2021_01_08_423993	840	121	50	50	CD
10_1101-2021_01_08_423993	840	122	100	100	CD
10_1101-2021_01_08_423993	840	123	250	250	CD
10_1101-2021_01_08_423993	840	124	5	5	CD
10_1101-2021_01_08_423993	840	125	’	'	''
10_1101-2021_01_08_423993	840	126	overhang	overhang	NN
10_1101-2021_01_08_423993	840	127	NE	NE	NNP
10_1101-2021_01_08_423993	840	128	10	10	CD
10_1101-2021_01_08_423993	840	129	50	50	CD
10_1101-2021_01_08_423993	840	130	100	100	CD
10_1101-2021_01_08_423993	840	131	250	250	CD
10_1101-2021_01_08_423993	840	132	NE	NE	NNP
10_1101-2021_01_08_423993	840	133	10	10	CD
10_1101-2021_01_08_423993	840	134	50	50	CD
10_1101-2021_01_08_423993	840	135	100	100	CD
10_1101-2021_01_08_423993	840	136	250	250	CD
10_1101-2021_01_08_423993	840	137	NE	NE	NNP
10_1101-2021_01_08_423993	840	138	10	10	CD
10_1101-2021_01_08_423993	840	139	50	50	CD
10_1101-2021_01_08_423993	840	140	100	100	CD
10_1101-2021_01_08_423993	840	141	250	250	CD
10_1101-2021_01_08_423993	840	142	5	5	CD
10_1101-2021_01_08_423993	840	143	’	'	''
10_1101-2021_01_08_423993	840	144	PHO	pho	NN
10_1101-2021_01_08_423993	840	145	3	3	CD
10_1101-2021_01_08_423993	840	146	’	’	NN
10_1101-2021_01_08_423993	840	147	5	5	CD
10_1101-2021_01_08_423993	840	148	’	'	''
10_1101-2021_01_08_423993	840	149	OH	oh	UH
10_1101-2021_01_08_423993	840	150	3	3	CD
10_1101-2021_01_08_423993	840	151	’	'	''
10_1101-2021_01_08_423993	840	152	5	5	CD
10_1101-2021_01_08_423993	840	153	’	'	''
10_1101-2021_01_08_423993	840	154	BIO	BIO	NNP
10_1101-2021_01_08_423993	840	155	3	3	CD
10_1101-2021_01_08_423993	840	156	’	'	''
10_1101-2021_01_08_423993	840	157	5	5	CD
10_1101-2021_01_08_423993	840	158	’	'	''
10_1101-2021_01_08_423993	840	159	PHO	pho	NN
10_1101-2021_01_08_423993	840	160	3	3	CD
10_1101-2021_01_08_423993	840	161	’	'	''
10_1101-2021_01_08_423993	840	162	22	22	CD
10_1101-2021_01_08_423993	840	163	nt	nt	RB
10_1101-2021_01_08_423993	840	164	5	5	CD
10_1101-2021_01_08_423993	840	165	’	'	''
10_1101-2021_01_08_423993	840	166	OH	oh	UH
10_1101-2021_01_08_423993	840	167	3	3	CD
10_1101-2021_01_08_423993	840	168	’	'	''
10_1101-2021_01_08_423993	840	169	22	22	CD
10_1101-2021_01_08_423993	840	170	nt	nt	RB
10_1101-2021_01_08_423993	840	171	5	5	CD
10_1101-2021_01_08_423993	840	172	’	'	''
10_1101-2021_01_08_423993	840	173	BIO	BIO	NNP
10_1101-2021_01_08_423993	840	174	3	3	CD
10_1101-2021_01_08_423993	840	175	’	'	''
10_1101-2021_01_08_423993	840	176	22	22	CD
10_1101-2021_01_08_423993	840	177	nt	nt	RB
10_1101-2021_01_08_423993	840	178	5	5	CD
10_1101-2021_01_08_423993	840	179	’	'	''
10_1101-2021_01_08_423993	840	180	PHO	pho	NN
10_1101-2021_01_08_423993	840	181	3	3	CD
10_1101-2021_01_08_423993	840	182	’	'	''
10_1101-2021_01_08_423993	840	183	22	22	CD
10_1101-2021_01_08_423993	840	184	nt	nt	RB
10_1101-2021_01_08_423993	840	185	5	5	CD
10_1101-2021_01_08_423993	840	186	’	'	''
10_1101-2021_01_08_423993	840	187	OH	oh	UH
10_1101-2021_01_08_423993	840	188	3	3	CD
10_1101-2021_01_08_423993	840	189	’	'	''
10_1101-2021_01_08_423993	840	190	22	22	CD
10_1101-2021_01_08_423993	840	191	nt	nt	RB
10_1101-2021_01_08_423993	840	192	5	5	CD
10_1101-2021_01_08_423993	840	193	’	'	''
10_1101-2021_01_08_423993	840	194	BIO	BIO	NNP
10_1101-2021_01_08_423993	840	195	3	3	CD
10_1101-2021_01_08_423993	840	196	’	'	''
10_1101-2021_01_08_423993	840	197	22	22	CD
10_1101-2021_01_08_423993	840	198	nt	nt	RB
10_1101-2021_01_08_423993	840	199	3	3	CD
10_1101-2021_01_08_423993	840	200	’	’	POS
10_1101-2021_01_08_423993	840	201	overhang	overhang	NN
10_1101-2021_01_08_423993	840	202	B	B	NNP
10_1101-2021_01_08_423993	840	203	A	a	DT
10_1101-2021_01_08_423993	840	204	22	22	CD
10_1101-2021_01_08_423993	840	205	nt	nt	RB
10_1101-2021_01_08_423993	840	206	5	5	CD
10_1101-2021_01_08_423993	840	207	’	’	CD
10_1101-2021_01_08_423993	840	208	3	3	CD
10_1101-2021_01_08_423993	840	209	’	'	''
10_1101-2021_01_08_423993	840	210	3	3	CD
10_1101-2021_01_08_423993	840	211	’	'	''
10_1101-2021_01_08_423993	840	212	5	5	CD
10_1101-2021_01_08_423993	840	213	’	'	''
10_1101-2021_01_08_423993	840	214	5	5	CD
10_1101-2021_01_08_423993	840	215	’	’	CD
10_1101-2021_01_08_423993	840	216	3	3	CD
10_1101-2021_01_08_423993	840	217	’	'	''
10_1101-2021_01_08_423993	840	218	5	5	CD
10_1101-2021_01_08_423993	840	219	’	’	CD
10_1101-2021_01_08_423993	840	220	3	3	CD
10_1101-2021_01_08_423993	840	221	’	'	''
10_1101-2021_01_08_423993	840	222	3	3	CD
10_1101-2021_01_08_423993	840	223	’	'	''
10_1101-2021_01_08_423993	840	224	5	5	CD
10_1101-2021_01_08_423993	840	225	’	'	''
10_1101-2021_01_08_423993	840	226	5	5	CD
10_1101-2021_01_08_423993	840	227	’	’	CD
10_1101-2021_01_08_423993	840	228	3	3	CD
10_1101-2021_01_08_423993	840	229	’	'	''
10_1101-2021_01_08_423993	840	230	3	3	CD
10_1101-2021_01_08_423993	840	231	’	’	CD
10_1101-2021_01_08_423993	840	232	5	5	CD
10_1101-2021_01_08_423993	840	233	’	'	''
10_1101-2021_01_08_423993	840	234	22nt	22nt	CD
10_1101-2021_01_08_423993	840	235	5	5	CD
10_1101-2021_01_08_423993	840	236	’	’	CD
10_1101-2021_01_08_423993	840	237	3	3	CD
10_1101-2021_01_08_423993	840	238	’	'	''
10_1101-2021_01_08_423993	840	239	3	3	CD
10_1101-2021_01_08_423993	840	240	’	’	CD
10_1101-2021_01_08_423993	840	241	5	5	CD
10_1101-2021_01_08_423993	840	242	’	'	''
10_1101-2021_01_08_423993	840	243	22nt	22nt	CD
10_1101-2021_01_08_423993	840	244	22	22	CD
10_1101-2021_01_08_423993	840	245	nt	nt	RB
10_1101-2021_01_08_423993	840	246	5	5	CD
10_1101-2021_01_08_423993	840	247	’	’	CD
10_1101-2021_01_08_423993	840	248	3	3	CD
10_1101-2021_01_08_423993	840	249	’	'	''
10_1101-2021_01_08_423993	840	250	3	3	CD
10_1101-2021_01_08_423993	840	251	’	'	''
10_1101-2021_01_08_423993	840	252	5	5	CD
10_1101-2021_01_08_423993	840	253	’	'	''
10_1101-2021_01_08_423993	840	254	5	5	CD
10_1101-2021_01_08_423993	840	255	’	’	CD
10_1101-2021_01_08_423993	840	256	3	3	CD
10_1101-2021_01_08_423993	840	257	’	'	''
10_1101-2021_01_08_423993	840	258	3	3	CD
10_1101-2021_01_08_423993	840	259	’	'	''
10_1101-2021_01_08_423993	840	260	5	5	CD
10_1101-2021_01_08_423993	840	261	’	'	''
10_1101-2021_01_08_423993	840	262	22	22	CD
10_1101-2021_01_08_423993	840	263	nt	nt	RB
10_1101-2021_01_08_423993	840	264	22	22	CD
10_1101-2021_01_08_423993	840	265	nt	nt	RB
10_1101-2021_01_08_423993	840	266	5	5	CD
10_1101-2021_01_08_423993	840	267	’	’	CD
10_1101-2021_01_08_423993	840	268	3	3	CD
10_1101-2021_01_08_423993	840	269	’	'	''
10_1101-2021_01_08_423993	840	270	3	3	CD
10_1101-2021_01_08_423993	840	271	’	’	CD
10_1101-2021_01_08_423993	840	272	5	5	CD
10_1101-2021_01_08_423993	840	273	’	’	CD
10_1101-2021_01_08_423993	840	274	.CC	.CC	:
10_1101-2021_01_08_423993	840	275	-	-	:
10_1101-2021_01_08_423993	840	276	BY	by	IN
10_1101-2021_01_08_423993	840	277	4.0	4.0	CD
10_1101-2021_01_08_423993	840	278	International	international	JJ
10_1101-2021_01_08_423993	840	279	licensemade	licensemade	NN
10_1101-2021_01_08_423993	840	280	available	available	JJ
10_1101-2021_01_08_423993	840	281	under	under	IN
10_1101-2021_01_08_423993	840	282	a	a	DT
10_1101-2021_01_08_423993	840	283	(	(	-LRB-
10_1101-2021_01_08_423993	840	284	which	which	WDT
10_1101-2021_01_08_423993	840	285	was	be	VBD
10_1101-2021_01_08_423993	840	286	not	not	RB
10_1101-2021_01_08_423993	840	287	certified	certify	VBN
10_1101-2021_01_08_423993	840	288	by	by	IN
10_1101-2021_01_08_423993	840	289	peer	peer	NN
10_1101-2021_01_08_423993	840	290	review	review	NN
10_1101-2021_01_08_423993	840	291	)	)	-RRB-
10_1101-2021_01_08_423993	840	292	is	be	VBZ
10_1101-2021_01_08_423993	840	293	the	the	DT
10_1101-2021_01_08_423993	840	294	author	author	NN
10_1101-2021_01_08_423993	840	295	/	/	SYM
10_1101-2021_01_08_423993	840	296	funder	funder	NN
10_1101-2021_01_08_423993	840	297	,	,	,
10_1101-2021_01_08_423993	840	298	who	who	WP
10_1101-2021_01_08_423993	840	299	has	have	VBZ
10_1101-2021_01_08_423993	840	300	granted	grant	VBN
10_1101-2021_01_08_423993	840	301	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	840	302	a	a	DT
10_1101-2021_01_08_423993	840	303	license	license	NN
10_1101-2021_01_08_423993	840	304	to	to	TO
10_1101-2021_01_08_423993	840	305	display	display	VB
10_1101-2021_01_08_423993	840	306	the	the	DT
10_1101-2021_01_08_423993	840	307	preprint	preprint	NN
10_1101-2021_01_08_423993	840	308	in	in	IN
10_1101-2021_01_08_423993	840	309	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	840	310	.	.	.
10_1101-2021_01_08_423993	841	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	841	2	is	be	VBZ
10_1101-2021_01_08_423993	841	3	The	the	DT
10_1101-2021_01_08_423993	841	4	copyright	copyright	NN
10_1101-2021_01_08_423993	841	5	holder	holder	NN
10_1101-2021_01_08_423993	841	6	for	for	IN
10_1101-2021_01_08_423993	841	7	this	this	DT
10_1101-2021_01_08_423993	841	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	841	9	version	version	NN
10_1101-2021_01_08_423993	841	10	posted	post	VBD
10_1101-2021_01_08_423993	841	11	January	January	NNP
10_1101-2021_01_08_423993	841	12	8	8	CD
10_1101-2021_01_08_423993	841	13	,	,	,
10_1101-2021_01_08_423993	841	14	2021	2021	CD
10_1101-2021_01_08_423993	841	15	.	.	.
10_1101-2021_01_08_423993	841	16	;	;	:
10_1101-2021_01_08_423993	841	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	841	18	:	:	:
10_1101-2021_01_08_423993	841	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	841	20	preprint	preprint	NN
10_1101-2021_01_08_423993	841	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	CD
10_1101-2021_01_08_423993	841	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	841	23	Figure	Figure	NNP
10_1101-2021_01_08_423993	841	24	8	8	CD
10_1101-2021_01_08_423993	841	25	:	:	:
10_1101-2021_01_08_423993	841	26	Views	view	NNS
10_1101-2021_01_08_423993	841	27	from	from	IN
10_1101-2021_01_08_423993	841	28	structure	structure	NN
10_1101-2021_01_08_423993	841	29	of	of	IN
10_1101-2021_01_08_423993	841	30	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	841	31	D37A	D37A	NNP
10_1101-2021_01_08_423993	841	32	,	,	,
10_1101-2021_01_08_423993	841	33	H33A	H33A	NNP
10_1101-2021_01_08_423993	841	34	and	and	CC
10_1101-2021_01_08_423993	841	35	H35D	H35D	NNP
10_1101-2021_01_08_423993	841	36	variants	variant	NNS
10_1101-2021_01_08_423993	841	37	.	.	.
10_1101-2021_01_08_423993	842	1	A.	A.	NNP
10_1101-2021_01_08_423993	843	1	An	an	DT
10_1101-2021_01_08_423993	843	2	overlay	overlay	NN
10_1101-2021_01_08_423993	843	3	of	of	IN
10_1101-2021_01_08_423993	843	4	the	the	DT
10_1101-2021_01_08_423993	843	5	four	four	CD
10_1101-2021_01_08_423993	843	6	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	843	7	structures	structure	NNS
10_1101-2021_01_08_423993	843	8	:	:	:
10_1101-2021_01_08_423993	843	9	WT	WT	NNP
10_1101-2021_01_08_423993	843	10	(	(	-LRB-
10_1101-2021_01_08_423993	843	11	PDB:7AF1	PDB:7AF1	NNP
10_1101-2021_01_08_423993	843	12	)	)	-RRB-
10_1101-2021_01_08_423993	843	13	in	in	IN
10_1101-2021_01_08_423993	843	14	pink	pink	NN
10_1101-2021_01_08_423993	843	15	,	,	,
10_1101-2021_01_08_423993	843	16	D37A	d37a	JJ
10_1101-2021_01_08_423993	843	17	variant	variant	NN
10_1101-2021_01_08_423993	843	18	(	(	-LRB-
10_1101-2021_01_08_423993	843	19	PDB:7AFS	pdb:7afs	CC
10_1101-2021_01_08_423993	843	20	)	)	-RRB-
10_1101-2021_01_08_423993	843	21	in	in	IN
10_1101-2021_01_08_423993	843	22	yellow	yellow	NN
10_1101-2021_01_08_423993	843	23	,	,	,
10_1101-2021_01_08_423993	843	24	H33A	H33A	NNP
10_1101-2021_01_08_423993	843	25	variant	variant	JJ
10_1101-2021_01_08_423993	843	26	(	(	-LRB-
10_1101-2021_01_08_423993	843	27	PDB:7AFU	PDB:7AFU	NNP
10_1101-2021_01_08_423993	843	28	)	)	-RRB-
10_1101-2021_01_08_423993	843	29	in	in	IN
10_1101-2021_01_08_423993	843	30	cyan	cyan	NNP
10_1101-2021_01_08_423993	843	31	and	and	CC
10_1101-2021_01_08_423993	843	32	H35D	H35D	NNP
10_1101-2021_01_08_423993	843	33	patient	patient	NN
10_1101-2021_01_08_423993	843	34	mutation	mutation	NN
10_1101-2021_01_08_423993	843	35	(	(	-LRB-
10_1101-2021_01_08_423993	843	36	PDB:7AGI	PDB:7AGI	NNP
10_1101-2021_01_08_423993	843	37	)	)	-RRB-
10_1101-2021_01_08_423993	843	38	in	in	IN
10_1101-2021_01_08_423993	843	39	blue	blue	NNP
10_1101-2021_01_08_423993	843	40	,	,	,
10_1101-2021_01_08_423993	843	41	showing	show	VBG
10_1101-2021_01_08_423993	843	42	the	the	DT
10_1101-2021_01_08_423993	843	43	general	general	JJ
10_1101-2021_01_08_423993	843	44	architecture	architecture	NN
10_1101-2021_01_08_423993	843	45	of	of	IN
10_1101-2021_01_08_423993	843	46	the	the	DT
10_1101-2021_01_08_423993	843	47	three	three	CD
10_1101-2021_01_08_423993	843	48	variants	variant	NNS
10_1101-2021_01_08_423993	843	49	are	be	VBP
10_1101-2021_01_08_423993	843	50	the	the	DT
10_1101-2021_01_08_423993	843	51	same	same	JJ
10_1101-2021_01_08_423993	843	52	as	as	IN
10_1101-2021_01_08_423993	843	53	the	the	DT
10_1101-2021_01_08_423993	843	54	W	W	NNP
10_1101-2021_01_08_423993	843	55	structure	structure	NN
10_1101-2021_01_08_423993	843	56	.	.	.
10_1101-2021_01_08_423993	844	1	The	the	DT
10_1101-2021_01_08_423993	844	2	nickel	nickel	NN
10_1101-2021_01_08_423993	844	3	ion	ion	NN
10_1101-2021_01_08_423993	844	4	is	be	VBZ
10_1101-2021_01_08_423993	844	5	represented	represent	VBN
10_1101-2021_01_08_423993	844	6	as	as	IN
10_1101-2021_01_08_423993	844	7	green	green	JJ
10_1101-2021_01_08_423993	844	8	sphere	sphere	NN
10_1101-2021_01_08_423993	844	9	,	,	,
10_1101-2021_01_08_423993	844	10	and	and	CC
10_1101-2021_01_08_423993	844	11	the	the	DT
10_1101-2021_01_08_423993	844	12	zinc	zinc	NN
10_1101-2021_01_08_423993	844	13	ions	ion	NNS
10_1101-2021_01_08_423993	844	14	as	as	IN
10_1101-2021_01_08_423993	844	15	grey	grey	NN
10_1101-2021_01_08_423993	844	16	spheres	sphere	NNS
10_1101-2021_01_08_423993	844	17	.	.	.
10_1101-2021_01_08_423993	845	1	The	the	DT
10_1101-2021_01_08_423993	845	2	movement	movement	NN
10_1101-2021_01_08_423993	845	3	of	of	IN
10_1101-2021_01_08_423993	845	4	helix	helix	NNP
10_1101-2021_01_08_423993	845	5	αE	αE	NNP
10_1101-2021_01_08_423993	845	6	in	in	IN
10_1101-2021_01_08_423993	845	7	the	the	DT
10_1101-2021_01_08_423993	845	8	β	β	NNP
10_1101-2021_01_08_423993	845	9	-	-	HYPH
10_1101-2021_01_08_423993	845	10	CASP	CASP	NNP
10_1101-2021_01_08_423993	845	11	domain	domain	NN
10_1101-2021_01_08_423993	845	12	is	be	VBZ
10_1101-2021_01_08_423993	845	13	indicated	indicate	VBN
10_1101-2021_01_08_423993	845	14	by	by	IN
10_1101-2021_01_08_423993	845	15	a	a	DT
10_1101-2021_01_08_423993	845	16	red	red	JJ
10_1101-2021_01_08_423993	845	17	arrow	arrow	NN
10_1101-2021_01_08_423993	845	18	.	.	.
10_1101-2021_01_08_423993	846	1	B.	B.	NNP
10_1101-2021_01_08_423993	847	1	Left	leave	VBN
10_1101-2021_01_08_423993	847	2	:	:	:
10_1101-2021_01_08_423993	847	3	The	the	DT
10_1101-2021_01_08_423993	847	4	active	active	JJ
10_1101-2021_01_08_423993	847	5	site	site	NN
10_1101-2021_01_08_423993	847	6	of	of	IN
10_1101-2021_01_08_423993	847	7	D37A	d37a	JJ
10_1101-2021_01_08_423993	847	8	variant	variant	JJ
10_1101-2021_01_08_423993	847	9	has	have	VBZ
10_1101-2021_01_08_423993	847	10	a	a	DT
10_1101-2021_01_08_423993	847	11	single	single	JJ
10_1101-2021_01_08_423993	847	12	nickel	nickel	NN
10_1101-2021_01_08_423993	847	13	ion	ion	NN
10_1101-2021_01_08_423993	847	14	with	with	IN
10_1101-2021_01_08_423993	847	15	two	two	CD
10_1101-2021_01_08_423993	847	16	complexing	complexe	VBG
10_1101-2021_01_08_423993	847	17	water	water	NN
10_1101-2021_01_08_423993	847	18	molecules	molecule	NNS
10_1101-2021_01_08_423993	847	19	(	(	-LRB-
10_1101-2021_01_08_423993	847	20	red	red	JJ
10_1101-2021_01_08_423993	847	21	spheres	sphere	NNS
10_1101-2021_01_08_423993	847	22	)	)	-RRB-
10_1101-2021_01_08_423993	847	23	;	;	.
10_1101-2021_01_08_423993	847	24	Right	right	UH
10_1101-2021_01_08_423993	847	25	:	:	:
10_1101-2021_01_08_423993	847	26	the	the	DT
10_1101-2021_01_08_423993	847	27	active	active	JJ
10_1101-2021_01_08_423993	847	28	site	site	NN
10_1101-2021_01_08_423993	847	29	residues	residue	NNS
10_1101-2021_01_08_423993	847	30	of	of	IN
10_1101-2021_01_08_423993	847	31	WT	WT	NNP
10_1101-2021_01_08_423993	847	32	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	847	33	(	(	-LRB-
10_1101-2021_01_08_423993	847	34	pink	pink	NNP
10_1101-2021_01_08_423993	847	35	)	)	-RRB-
10_1101-2021_01_08_423993	847	36	,	,	,
10_1101-2021_01_08_423993	847	37	superimposed	superimpose	VBN
10_1101-2021_01_08_423993	847	38	with	with	IN
10_1101-2021_01_08_423993	847	39	those	those	DT
10_1101-2021_01_08_423993	847	40	of	of	IN
10_1101-2021_01_08_423993	847	41	the	the	DT
10_1101-2021_01_08_423993	847	42	D37A	D37A	NNP
10_1101-2021_01_08_423993	847	43	variant	variant	JJ
10_1101-2021_01_08_423993	847	44	(	(	-LRB-
10_1101-2021_01_08_423993	847	45	yellow	yellow	JJ
10_1101-2021_01_08_423993	847	46	)	)	-RRB-
10_1101-2021_01_08_423993	847	47	.	.	.
10_1101-2021_01_08_423993	848	1	Aside	aside	RB
10_1101-2021_01_08_423993	848	2	from	from	IN
10_1101-2021_01_08_423993	848	3	loss	loss	NN
10_1101-2021_01_08_423993	848	4	of	of	IN
10_1101-2021_01_08_423993	848	5	the	the	DT
10_1101-2021_01_08_423993	848	6	second	second	JJ
10_1101-2021_01_08_423993	848	7	metal	metal	NN
10_1101-2021_01_08_423993	848	8	in	in	IN
10_1101-2021_01_08_423993	848	9	the	the	DT
10_1101-2021_01_08_423993	848	10	D37A	D37A	NNP
10_1101-2021_01_08_423993	848	11	mutant	mutant	NN
10_1101-2021_01_08_423993	848	12	,	,	,
10_1101-2021_01_08_423993	848	13	there	there	EX
10_1101-2021_01_08_423993	848	14	is	be	VBZ
10_1101-2021_01_08_423993	848	15	little	little	JJ
10_1101-2021_01_08_423993	848	16	movement	movement	NN
10_1101-2021_01_08_423993	848	17	at	at	IN
10_1101-2021_01_08_423993	848	18	the	the	DT
10_1101-2021_01_08_423993	848	19	active	active	JJ
10_1101-2021_01_08_423993	848	20	site	site	NN
10_1101-2021_01_08_423993	848	21	.	.	.
10_1101-2021_01_08_423993	849	1	C.	C.	NNP
10_1101-2021_01_08_423993	849	2	Active	Active	NNP
10_1101-2021_01_08_423993	849	3	site	site	NN
10_1101-2021_01_08_423993	849	4	residues	residue	NNS
10_1101-2021_01_08_423993	849	5	of	of	IN
10_1101-2021_01_08_423993	849	6	the	the	DT
10_1101-2021_01_08_423993	849	7	H33A	H33A	NNP
10_1101-2021_01_08_423993	849	8	variant	variant	NN
10_1101-2021_01_08_423993	849	9	(	(	-LRB-
10_1101-2021_01_08_423993	849	10	cyan	cyan	NN
10_1101-2021_01_08_423993	849	11	;	;	:
10_1101-2021_01_08_423993	849	12	left	leave	VBN
10_1101-2021_01_08_423993	849	13	)	)	-RRB-
10_1101-2021_01_08_423993	849	14	and	and	CC
10_1101-2021_01_08_423993	849	15	an	an	DT
10_1101-2021_01_08_423993	849	16	overlay	overlay	NN
10_1101-2021_01_08_423993	849	17	(	(	-LRB-
10_1101-2021_01_08_423993	849	18	right	right	UH
10_1101-2021_01_08_423993	849	19	)	)	-RRB-
10_1101-2021_01_08_423993	849	20	with	with	IN
10_1101-2021_01_08_423993	849	21	WT	WT	NNP
10_1101-2021_01_08_423993	849	22	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	849	23	(	(	-LRB-
10_1101-2021_01_08_423993	849	24	pink	pink	NN
10_1101-2021_01_08_423993	849	25	)	)	-RRB-
10_1101-2021_01_08_423993	849	26	.	.	.
10_1101-2021_01_08_423993	850	1	The	the	DT
10_1101-2021_01_08_423993	850	2	two	two	CD
10_1101-2021_01_08_423993	850	3	distinguishing	distinguish	VBG
10_1101-2021_01_08_423993	850	4	features	feature	NNS
10_1101-2021_01_08_423993	850	5	of	of	IN
10_1101-2021_01_08_423993	850	6	H33A	H33A	NNP
10_1101-2021_01_08_423993	850	7	variant	variant	NN
10_1101-2021_01_08_423993	850	8	are	be	VBP
10_1101-2021_01_08_423993	850	9	a	a	DT
10_1101-2021_01_08_423993	850	10	lack	lack	NN
10_1101-2021_01_08_423993	850	11	of	of	IN
10_1101-2021_01_08_423993	850	12	metal	metal	NN
10_1101-2021_01_08_423993	850	13	ions	ion	NNS
10_1101-2021_01_08_423993	850	14	and	and	CC
10_1101-2021_01_08_423993	850	15	movement	movement	NN
10_1101-2021_01_08_423993	850	16	of	of	IN
10_1101-2021_01_08_423993	850	17	the	the	DT
10_1101-2021_01_08_423993	850	18	loop	loop	NN
10_1101-2021_01_08_423993	850	19	containing	contain	VBG
10_1101-2021_01_08_423993	850	20	His115	his115	CD
10_1101-2021_01_08_423993	850	21	.	.	.
10_1101-2021_01_08_423993	851	1	D.	D.	NNP
10_1101-2021_01_08_423993	851	2	The	the	DT
10_1101-2021_01_08_423993	851	3	active	active	JJ
10_1101-2021_01_08_423993	851	4	site	site	NN
10_1101-2021_01_08_423993	851	5	of	of	IN
10_1101-2021_01_08_423993	851	6	the	the	DT
10_1101-2021_01_08_423993	851	7	H35D	H35D	NNP
10_1101-2021_01_08_423993	851	8	variant	variant	NN
10_1101-2021_01_08_423993	851	9	(	(	-LRB-
10_1101-2021_01_08_423993	851	10	blue	blue	JJ
10_1101-2021_01_08_423993	851	11	;	;	:
10_1101-2021_01_08_423993	851	12	left	left	JJ
10_1101-2021_01_08_423993	851	13	)	)	-RRB-
10_1101-2021_01_08_423993	851	14	and	and	CC
10_1101-2021_01_08_423993	851	15	an	an	DT
10_1101-2021_01_08_423993	851	16	overlay	overlay	NN
10_1101-2021_01_08_423993	851	17	(	(	-LRB-
10_1101-2021_01_08_423993	851	18	right	right	UH
10_1101-2021_01_08_423993	851	19	)	)	-RRB-
10_1101-2021_01_08_423993	851	20	with	with	IN
10_1101-2021_01_08_423993	851	21	WT	WT	NNP
10_1101-2021_01_08_423993	851	22	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	851	23	(	(	-LRB-
10_1101-2021_01_08_423993	851	24	pink	pink	NN
10_1101-2021_01_08_423993	851	25	)	)	-RRB-
10_1101-2021_01_08_423993	851	26	.	.	.
10_1101-2021_01_08_423993	852	1	The	the	DT
10_1101-2021_01_08_423993	852	2	H35D	H35D	NNP
10_1101-2021_01_08_423993	852	3	point	point	NN
10_1101-2021_01_08_423993	852	4	substitution	substitution	NN
10_1101-2021_01_08_423993	852	5	is	be	VBZ
10_1101-2021_01_08_423993	852	6	present	present	JJ
10_1101-2021_01_08_423993	852	7	in	in	IN
10_1101-2021_01_08_423993	852	8	patients	patient	NNS
10_1101-2021_01_08_423993	852	9	with	with	IN
10_1101-2021_01_08_423993	852	10	Omen	Omen	NNP
10_1101-2021_01_08_423993	852	11	syndrome	syndrome	NN
10_1101-2021_01_08_423993	852	12	.	.	.
10_1101-2021_01_08_423993	853	1	This	this	DT
10_1101-2021_01_08_423993	853	2	variant	variant	NN
10_1101-2021_01_08_423993	853	3	lacks	lack	VBZ
10_1101-2021_01_08_423993	853	4	both	both	DT
10_1101-2021_01_08_423993	853	5	metal	metal	NN
10_1101-2021_01_08_423993	853	6	ions	ion	NNS
10_1101-2021_01_08_423993	853	7	,	,	,
10_1101-2021_01_08_423993	853	8	similarly	similarly	RB
10_1101-2021_01_08_423993	853	9	to	to	IN
10_1101-2021_01_08_423993	853	10	the	the	DT
10_1101-2021_01_08_423993	853	11	H33A	H33A	NNP
10_1101-2021_01_08_423993	853	12	variant	variant	NN
10_1101-2021_01_08_423993	853	13	.	.	.
10_1101-2021_01_08_423993	854	1	.CC	.CC	NFP
10_1101-2021_01_08_423993	854	2	-	-	:
10_1101-2021_01_08_423993	854	3	BY	by	IN
10_1101-2021_01_08_423993	854	4	4.0	4.0	CD
10_1101-2021_01_08_423993	854	5	International	international	JJ
10_1101-2021_01_08_423993	854	6	licensemade	licensemade	NN
10_1101-2021_01_08_423993	854	7	available	available	JJ
10_1101-2021_01_08_423993	854	8	under	under	IN
10_1101-2021_01_08_423993	854	9	a	a	DT
10_1101-2021_01_08_423993	854	10	(	(	-LRB-
10_1101-2021_01_08_423993	854	11	which	which	WDT
10_1101-2021_01_08_423993	854	12	was	be	VBD
10_1101-2021_01_08_423993	854	13	not	not	RB
10_1101-2021_01_08_423993	854	14	certified	certify	VBN
10_1101-2021_01_08_423993	854	15	by	by	IN
10_1101-2021_01_08_423993	854	16	peer	peer	NN
10_1101-2021_01_08_423993	854	17	review	review	NN
10_1101-2021_01_08_423993	854	18	)	)	-RRB-
10_1101-2021_01_08_423993	854	19	is	be	VBZ
10_1101-2021_01_08_423993	854	20	the	the	DT
10_1101-2021_01_08_423993	854	21	author	author	NN
10_1101-2021_01_08_423993	854	22	/	/	SYM
10_1101-2021_01_08_423993	854	23	funder	funder	NN
10_1101-2021_01_08_423993	854	24	,	,	,
10_1101-2021_01_08_423993	854	25	who	who	WP
10_1101-2021_01_08_423993	854	26	has	have	VBZ
10_1101-2021_01_08_423993	854	27	granted	grant	VBN
10_1101-2021_01_08_423993	854	28	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	854	29	a	a	DT
10_1101-2021_01_08_423993	854	30	license	license	NN
10_1101-2021_01_08_423993	854	31	to	to	TO
10_1101-2021_01_08_423993	854	32	display	display	VB
10_1101-2021_01_08_423993	854	33	the	the	DT
10_1101-2021_01_08_423993	854	34	preprint	preprint	NN
10_1101-2021_01_08_423993	854	35	in	in	IN
10_1101-2021_01_08_423993	854	36	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	854	37	.	.	.
10_1101-2021_01_08_423993	855	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	855	2	is	be	VBZ
10_1101-2021_01_08_423993	855	3	The	the	DT
10_1101-2021_01_08_423993	855	4	copyright	copyright	NN
10_1101-2021_01_08_423993	855	5	holder	holder	NN
10_1101-2021_01_08_423993	855	6	for	for	IN
10_1101-2021_01_08_423993	855	7	this	this	DT
10_1101-2021_01_08_423993	855	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	855	9	version	version	NN
10_1101-2021_01_08_423993	855	10	posted	post	VBD
10_1101-2021_01_08_423993	855	11	January	January	NNP
10_1101-2021_01_08_423993	855	12	8	8	CD
10_1101-2021_01_08_423993	855	13	,	,	,
10_1101-2021_01_08_423993	855	14	2021	2021	CD
10_1101-2021_01_08_423993	855	15	.	.	.
10_1101-2021_01_08_423993	855	16	;	;	:
10_1101-2021_01_08_423993	855	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	855	18	:	:	:
10_1101-2021_01_08_423993	855	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	855	20	preprint	preprint	NN
10_1101-2021_01_08_423993	855	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	CD
10_1101-2021_01_08_423993	855	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	855	23	Figure	Figure	NNP
10_1101-2021_01_08_423993	855	24	9	9	CD
10_1101-2021_01_08_423993	855	25	:	:	:
10_1101-2021_01_08_423993	855	26	Comparing	compare	VBG
10_1101-2021_01_08_423993	855	27	the	the	DT
10_1101-2021_01_08_423993	855	28	activity	activity	NN
10_1101-2021_01_08_423993	855	29	of	of	IN
10_1101-2021_01_08_423993	855	30	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	855	31	variants	variant	NNS
10_1101-2021_01_08_423993	855	32	vs	vs	IN
10_1101-2021_01_08_423993	855	33	WT	WT	NNP
10_1101-2021_01_08_423993	855	34	protein	protein	NN
10_1101-2021_01_08_423993	855	35	.	.	.
10_1101-2021_01_08_423993	856	1	Increasing	increase	VBG
10_1101-2021_01_08_423993	856	2	amounts	amount	NNS
10_1101-2021_01_08_423993	856	3	(	(	-LRB-
10_1101-2021_01_08_423993	856	4	from	from	IN
10_1101-2021_01_08_423993	856	5	0	0	CD
10_1101-2021_01_08_423993	856	6	to	to	IN
10_1101-2021_01_08_423993	856	7	250	250	CD
10_1101-2021_01_08_423993	856	8	nM	nM	NNP
10_1101-2021_01_08_423993	856	9	)	)	-RRB-
10_1101-2021_01_08_423993	856	10	of	of	IN
10_1101-2021_01_08_423993	856	11	WT	WT	NNP
10_1101-2021_01_08_423993	856	12	and	and	CC
10_1101-2021_01_08_423993	856	13	mutant	mutant	NNP
10_1101-2021_01_08_423993	856	14	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	856	15	proteins	protein	NNS
10_1101-2021_01_08_423993	856	16	(	(	-LRB-
10_1101-2021_01_08_423993	856	17	as	as	IN
10_1101-2021_01_08_423993	856	18	indicated	indicate	VBN
10_1101-2021_01_08_423993	856	19	)	)	-RRB-
10_1101-2021_01_08_423993	856	20	were	be	VBD
10_1101-2021_01_08_423993	856	21	incubated	incubate	VBN
10_1101-2021_01_08_423993	856	22	with	with	IN
10_1101-2021_01_08_423993	856	23	10	10	CD
10_1101-2021_01_08_423993	856	24	nM	nM	NNP
10_1101-2021_01_08_423993	856	25	of	of	IN
10_1101-2021_01_08_423993	856	26	51	51	CD
10_1101-2021_01_08_423993	856	27	nucleotide	nucleotide	JJ
10_1101-2021_01_08_423993	856	28	ssDNA	ssDNA	NNP
10_1101-2021_01_08_423993	856	29	substrate	substrate	NN
10_1101-2021_01_08_423993	856	30	for	for	IN
10_1101-2021_01_08_423993	856	31	30	30	CD
10_1101-2021_01_08_423993	856	32	min	min	NN
10_1101-2021_01_08_423993	856	33	at	at	IN
10_1101-2021_01_08_423993	856	34	37	37	CD
10_1101-2021_01_08_423993	856	35	°	°	NNS
10_1101-2021_01_08_423993	856	36	C	C	NNP
10_1101-2021_01_08_423993	856	37	.	.	.
10_1101-2021_01_08_423993	857	1	Reaction	reaction	NN
10_1101-2021_01_08_423993	857	2	products	product	NNS
10_1101-2021_01_08_423993	857	3	were	be	VBD
10_1101-2021_01_08_423993	857	4	subsequently	subsequently	RB
10_1101-2021_01_08_423993	857	5	analysed	analyse	VBN
10_1101-2021_01_08_423993	857	6	by	by	IN
10_1101-2021_01_08_423993	857	7	20	20	CD
10_1101-2021_01_08_423993	857	8	%	%	NN
10_1101-2021_01_08_423993	857	9	denaturing	denature	VBG
10_1101-2021_01_08_423993	857	10	PAGE	PAGE	NNP
10_1101-2021_01_08_423993	857	11	.	.	.
10_1101-2021_01_08_423993	858	1	The	the	DT
10_1101-2021_01_08_423993	858	2	size	size	NN
10_1101-2021_01_08_423993	858	3	(	(	-LRB-
10_1101-2021_01_08_423993	858	4	in	in	IN
10_1101-2021_01_08_423993	858	5	nucleotides	nucleotide	NNS
10_1101-2021_01_08_423993	858	6	)	)	-RRB-
10_1101-2021_01_08_423993	858	7	of	of	IN
10_1101-2021_01_08_423993	858	8	the	the	DT
10_1101-2021_01_08_423993	858	9	marker	marker	NN
10_1101-2021_01_08_423993	858	10	oligonucleotides	oligonucleotide	NNS
10_1101-2021_01_08_423993	858	11	are	be	VBP
10_1101-2021_01_08_423993	858	12	indicated	indicate	VBN
10_1101-2021_01_08_423993	858	13	on	on	IN
10_1101-2021_01_08_423993	858	14	the	the	DT
10_1101-2021_01_08_423993	858	15	left	left	JJ
10_1101-2021_01_08_423993	858	16	-	-	HYPH
10_1101-2021_01_08_423993	858	17	hand	hand	NN
10_1101-2021_01_08_423993	858	18	side	side	NN
10_1101-2021_01_08_423993	858	19	of	of	IN
10_1101-2021_01_08_423993	858	20	the	the	DT
10_1101-2021_01_08_423993	858	21	corresponding	correspond	VBG
10_1101-2021_01_08_423993	858	22	bands	band	NNS
10_1101-2021_01_08_423993	858	23	.	.	.
10_1101-2021_01_08_423993	859	1	.CC	.CC	NFP
10_1101-2021_01_08_423993	859	2	-	-	:
10_1101-2021_01_08_423993	859	3	BY	by	IN
10_1101-2021_01_08_423993	859	4	4.0	4.0	CD
10_1101-2021_01_08_423993	859	5	International	international	JJ
10_1101-2021_01_08_423993	859	6	licensemade	licensemade	NN
10_1101-2021_01_08_423993	859	7	available	available	JJ
10_1101-2021_01_08_423993	859	8	under	under	IN
10_1101-2021_01_08_423993	859	9	a	a	DT
10_1101-2021_01_08_423993	859	10	(	(	-LRB-
10_1101-2021_01_08_423993	859	11	which	which	WDT
10_1101-2021_01_08_423993	859	12	was	be	VBD
10_1101-2021_01_08_423993	859	13	not	not	RB
10_1101-2021_01_08_423993	859	14	certified	certify	VBN
10_1101-2021_01_08_423993	859	15	by	by	IN
10_1101-2021_01_08_423993	859	16	peer	peer	NN
10_1101-2021_01_08_423993	859	17	review	review	NN
10_1101-2021_01_08_423993	859	18	)	)	-RRB-
10_1101-2021_01_08_423993	859	19	is	be	VBZ
10_1101-2021_01_08_423993	859	20	the	the	DT
10_1101-2021_01_08_423993	859	21	author	author	NN
10_1101-2021_01_08_423993	859	22	/	/	SYM
10_1101-2021_01_08_423993	859	23	funder	funder	NN
10_1101-2021_01_08_423993	859	24	,	,	,
10_1101-2021_01_08_423993	859	25	who	who	WP
10_1101-2021_01_08_423993	859	26	has	have	VBZ
10_1101-2021_01_08_423993	859	27	granted	grant	VBN
10_1101-2021_01_08_423993	859	28	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	859	29	a	a	DT
10_1101-2021_01_08_423993	859	30	license	license	NN
10_1101-2021_01_08_423993	859	31	to	to	TO
10_1101-2021_01_08_423993	859	32	display	display	VB
10_1101-2021_01_08_423993	859	33	the	the	DT
10_1101-2021_01_08_423993	859	34	preprint	preprint	NN
10_1101-2021_01_08_423993	859	35	in	in	IN
10_1101-2021_01_08_423993	859	36	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	859	37	.	.	.
10_1101-2021_01_08_423993	860	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	860	2	is	be	VBZ
10_1101-2021_01_08_423993	860	3	The	the	DT
10_1101-2021_01_08_423993	860	4	copyright	copyright	NN
10_1101-2021_01_08_423993	860	5	holder	holder	NN
10_1101-2021_01_08_423993	860	6	for	for	IN
10_1101-2021_01_08_423993	860	7	this	this	DT
10_1101-2021_01_08_423993	860	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	860	9	version	version	NN
10_1101-2021_01_08_423993	860	10	posted	post	VBD
10_1101-2021_01_08_423993	860	11	January	January	NNP
10_1101-2021_01_08_423993	860	12	8	8	CD
10_1101-2021_01_08_423993	860	13	,	,	,
10_1101-2021_01_08_423993	860	14	2021	2021	CD
10_1101-2021_01_08_423993	860	15	.	.	.
10_1101-2021_01_08_423993	860	16	;	;	:
10_1101-2021_01_08_423993	860	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	860	18	:	:	:
10_1101-2021_01_08_423993	860	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	860	20	preprint	preprint	NN
10_1101-2021_01_08_423993	860	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	CD
10_1101-2021_01_08_423993	860	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	860	23	Figure	Figure	NNP
10_1101-2021_01_08_423993	860	24	10	10	CD
10_1101-2021_01_08_423993	860	25	:	:	:
10_1101-2021_01_08_423993	860	26	Artemis	artemis	NN
10_1101-2021_01_08_423993	860	27	inhibition	inhibition	NN
10_1101-2021_01_08_423993	860	28	by	by	IN
10_1101-2021_01_08_423993	860	29	β	β	NNP
10_1101-2021_01_08_423993	860	30	-	-	HYPH
10_1101-2021_01_08_423993	860	31	lactam	lactam	NNP
10_1101-2021_01_08_423993	860	32	antibiotics	antibiotic	NNS
10_1101-2021_01_08_423993	860	33	.	.	.
10_1101-2021_01_08_423993	861	1	A.	A.	NNP
10_1101-2021_01_08_423993	862	1	Structures	structure	NNS
10_1101-2021_01_08_423993	862	2	of	of	IN
10_1101-2021_01_08_423993	862	3	selected	select	VBN
10_1101-2021_01_08_423993	862	4	β	β	NNP
10_1101-2021_01_08_423993	862	5	-	-	HYPH
10_1101-2021_01_08_423993	862	6	lactam	lactam	NNP
10_1101-2021_01_08_423993	862	7	antibacterial	antibacterial	NNP
10_1101-2021_01_08_423993	862	8	.	.	.
10_1101-2021_01_08_423993	863	1	B.	B.	NNP
10_1101-2021_01_08_423993	863	2	Inhibitor	Inhibitor	NNP
10_1101-2021_01_08_423993	863	3	profiles	profile	NNS
10_1101-2021_01_08_423993	863	4	of	of	IN
10_1101-2021_01_08_423993	863	5	β	β	NN
10_1101-2021_01_08_423993	863	6	-	-	HYPH
10_1101-2021_01_08_423993	863	7	lactams	lactam	NNS
10_1101-2021_01_08_423993	863	8	on	on	IN
10_1101-2021_01_08_423993	863	9	the	the	DT
10_1101-2021_01_08_423993	863	10	nuclease	nuclease	NN
10_1101-2021_01_08_423993	863	11	activity	activity	NN
10_1101-2021_01_08_423993	863	12	of	of	IN
10_1101-2021_01_08_423993	863	13	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	863	14	was	be	VBD
10_1101-2021_01_08_423993	863	15	assessed	assess	VBN
10_1101-2021_01_08_423993	863	16	via	via	IN
10_1101-2021_01_08_423993	863	17	a	a	DT
10_1101-2021_01_08_423993	863	18	real	real	JJ
10_1101-2021_01_08_423993	863	19	-	-	HYPH
10_1101-2021_01_08_423993	863	20	time	time	NN
10_1101-2021_01_08_423993	863	21	fluorescence-	fluorescence-	NN
10_1101-2021_01_08_423993	863	22	based	base	VBN
10_1101-2021_01_08_423993	863	23	nuclease	nuclease	NNP
10_1101-2021_01_08_423993	863	24	assay	assay	NNP
10_1101-2021_01_08_423993	863	25	.	.	.
10_1101-2021_01_08_423993	864	1	C.	C.	NNP
10_1101-2021_01_08_423993	864	2	Cartoon	Cartoon	NNP
10_1101-2021_01_08_423993	864	3	representation	representation	NN
10_1101-2021_01_08_423993	864	4	of	of	IN
10_1101-2021_01_08_423993	864	5	the	the	DT
10_1101-2021_01_08_423993	864	6	structure	structure	NN
10_1101-2021_01_08_423993	864	7	of	of	IN
10_1101-2021_01_08_423993	864	8	truncated	truncate	VBN
10_1101-2021_01_08_423993	864	9	Artemis	Artemis	NNP
10_1101-2021_01_08_423993	864	10	(	(	-LRB-
10_1101-2021_01_08_423993	864	11	aa1	aa1	NNP
10_1101-2021_01_08_423993	864	12	-	-	HYPH
10_1101-2021_01_08_423993	864	13	361	361	CD
10_1101-2021_01_08_423993	864	14	)	)	-RRB-
10_1101-2021_01_08_423993	864	15	with	with	IN
10_1101-2021_01_08_423993	864	16	a	a	DT
10_1101-2021_01_08_423993	864	17	ceftriaxone	ceftriaxone	JJ
10_1101-2021_01_08_423993	864	18	molecule	molecule	NN
10_1101-2021_01_08_423993	864	19	(	(	-LRB-
10_1101-2021_01_08_423993	864	20	in	in	IN
10_1101-2021_01_08_423993	864	21	white	white	NNP
10_1101-2021_01_08_423993	864	22	)	)	-RRB-
10_1101-2021_01_08_423993	864	23	bound	bind	VBN
10_1101-2021_01_08_423993	864	24	at	at	IN
10_1101-2021_01_08_423993	864	25	the	the	DT
10_1101-2021_01_08_423993	864	26	active	active	JJ
10_1101-2021_01_08_423993	864	27	site	site	NN
10_1101-2021_01_08_423993	864	28	.	.	.
10_1101-2021_01_08_423993	865	1	D.	D.	NNP
10_1101-2021_01_08_423993	865	2	Active	Active	NNP
10_1101-2021_01_08_423993	865	3	site	site	NN
10_1101-2021_01_08_423993	865	4	residues	residue	VBZ
10_1101-2021_01_08_423993	865	5	with	with	IN
10_1101-2021_01_08_423993	865	6	the	the	DT
10_1101-2021_01_08_423993	865	7	electron	electron	NN
10_1101-2021_01_08_423993	865	8	density	density	NN
10_1101-2021_01_08_423993	865	9	(	(	-LRB-
10_1101-2021_01_08_423993	865	10	Fo	Fo	NNP
10_1101-2021_01_08_423993	865	11	-	-	HYPH
10_1101-2021_01_08_423993	865	12	Fc	Fc	NNP
10_1101-2021_01_08_423993	865	13	)	)	-RRB-
10_1101-2021_01_08_423993	865	14	contoured	contour	VBD
10_1101-2021_01_08_423993	865	15	map	map	NN
10_1101-2021_01_08_423993	865	16	around	around	IN
10_1101-2021_01_08_423993	865	17	the	the	DT
10_1101-2021_01_08_423993	865	18	modelled	model	VBN
10_1101-2021_01_08_423993	865	19	Ceftriaxone	Ceftriaxone	NNP
10_1101-2021_01_08_423993	865	20	.	.	.
10_1101-2021_01_08_423993	866	1	The	the	DT
10_1101-2021_01_08_423993	866	2	map	map	NN
10_1101-2021_01_08_423993	866	3	is	be	VBZ
10_1101-2021_01_08_423993	866	4	contoured	contour	VBN
10_1101-2021_01_08_423993	866	5	at	at	IN
10_1101-2021_01_08_423993	866	6	the	the	DT
10_1101-2021_01_08_423993	866	7	1.0	1.0	CD
10_1101-2021_01_08_423993	866	8	σ	σ	NN
10_1101-2021_01_08_423993	866	9	level	level	NN
10_1101-2021_01_08_423993	866	10	and	and	CC
10_1101-2021_01_08_423993	866	11	was	be	VBD
10_1101-2021_01_08_423993	866	12	calculated	calculate	VBN
10_1101-2021_01_08_423993	866	13	before	before	IN
10_1101-2021_01_08_423993	866	14	the	the	DT
10_1101-2021_01_08_423993	866	15	Ceftriaxone	Ceftriaxone	NNP
10_1101-2021_01_08_423993	866	16	molecule	molecule	NN
10_1101-2021_01_08_423993	866	17	was	be	VBD
10_1101-2021_01_08_423993	866	18	included	include	VBN
10_1101-2021_01_08_423993	866	19	in	in	IN
10_1101-2021_01_08_423993	866	20	the	the	DT
10_1101-2021_01_08_423993	866	21	refinement	refinement	NN
10_1101-2021_01_08_423993	866	22	.	.	.
10_1101-2021_01_08_423993	867	1	.CC	.CC	NFP
10_1101-2021_01_08_423993	867	2	-	-	:
10_1101-2021_01_08_423993	867	3	BY	by	IN
10_1101-2021_01_08_423993	867	4	4.0	4.0	CD
10_1101-2021_01_08_423993	867	5	International	international	JJ
10_1101-2021_01_08_423993	867	6	licensemade	licensemade	NN
10_1101-2021_01_08_423993	867	7	available	available	JJ
10_1101-2021_01_08_423993	867	8	under	under	IN
10_1101-2021_01_08_423993	867	9	a	a	DT
10_1101-2021_01_08_423993	867	10	(	(	-LRB-
10_1101-2021_01_08_423993	867	11	which	which	WDT
10_1101-2021_01_08_423993	867	12	was	be	VBD
10_1101-2021_01_08_423993	867	13	not	not	RB
10_1101-2021_01_08_423993	867	14	certified	certify	VBN
10_1101-2021_01_08_423993	867	15	by	by	IN
10_1101-2021_01_08_423993	867	16	peer	peer	NN
10_1101-2021_01_08_423993	867	17	review	review	NN
10_1101-2021_01_08_423993	867	18	)	)	-RRB-
10_1101-2021_01_08_423993	867	19	is	be	VBZ
10_1101-2021_01_08_423993	867	20	the	the	DT
10_1101-2021_01_08_423993	867	21	author	author	NN
10_1101-2021_01_08_423993	867	22	/	/	SYM
10_1101-2021_01_08_423993	867	23	funder	funder	NN
10_1101-2021_01_08_423993	867	24	,	,	,
10_1101-2021_01_08_423993	867	25	who	who	WP
10_1101-2021_01_08_423993	867	26	has	have	VBZ
10_1101-2021_01_08_423993	867	27	granted	grant	VBN
10_1101-2021_01_08_423993	867	28	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	867	29	a	a	DT
10_1101-2021_01_08_423993	867	30	license	license	NN
10_1101-2021_01_08_423993	867	31	to	to	TO
10_1101-2021_01_08_423993	867	32	display	display	VB
10_1101-2021_01_08_423993	867	33	the	the	DT
10_1101-2021_01_08_423993	867	34	preprint	preprint	NN
10_1101-2021_01_08_423993	867	35	in	in	IN
10_1101-2021_01_08_423993	867	36	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	867	37	.	.	.
10_1101-2021_01_08_423993	868	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	868	2	is	be	VBZ
10_1101-2021_01_08_423993	868	3	The	the	DT
10_1101-2021_01_08_423993	868	4	copyright	copyright	NN
10_1101-2021_01_08_423993	868	5	holder	holder	NN
10_1101-2021_01_08_423993	868	6	for	for	IN
10_1101-2021_01_08_423993	868	7	this	this	DT
10_1101-2021_01_08_423993	868	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	868	9	version	version	NN
10_1101-2021_01_08_423993	868	10	posted	post	VBD
10_1101-2021_01_08_423993	868	11	January	January	NNP
10_1101-2021_01_08_423993	868	12	8	8	CD
10_1101-2021_01_08_423993	868	13	,	,	,
10_1101-2021_01_08_423993	868	14	2021	2021	CD
10_1101-2021_01_08_423993	868	15	.	.	.
10_1101-2021_01_08_423993	868	16	;	;	:
10_1101-2021_01_08_423993	868	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	868	18	:	:	:
10_1101-2021_01_08_423993	868	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	868	20	preprint	preprint	NN
10_1101-2021_01_08_423993	868	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	PRP
10_1101-2021_01_08_423993	868	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2021_01_08_423993	868	23	TABLES	tables	NN
10_1101-2021_01_08_423993	868	24	Table	table	NN
10_1101-2021_01_08_423993	868	25	1	1	CD
10_1101-2021_01_08_423993	868	26	:	:	:
10_1101-2021_01_08_423993	868	27	Data	data	NN
10_1101-2021_01_08_423993	868	28	collections	collection	NNS
10_1101-2021_01_08_423993	868	29	and	and	CC
10_1101-2021_01_08_423993	868	30	refinement	refinement	JJ
10_1101-2021_01_08_423993	868	31	statistics	statistic	NNS
10_1101-2021_01_08_423993	868	32	.	.	.
10_1101-2021_01_08_423993	869	1	*	*	NFP
10_1101-2021_01_08_423993	869	2	Data	datum	NNS
10_1101-2021_01_08_423993	869	3	in	in	IN
10_1101-2021_01_08_423993	869	4	parentheses	parenthesis	NNS
10_1101-2021_01_08_423993	869	5	is	be	VBZ
10_1101-2021_01_08_423993	869	6	for	for	IN
10_1101-2021_01_08_423993	869	7	the	the	DT
10_1101-2021_01_08_423993	869	8	high	high	JJ
10_1101-2021_01_08_423993	869	9	-	-	HYPH
10_1101-2021_01_08_423993	869	10	resolution	resolution	NN
10_1101-2021_01_08_423993	869	11	shell	shell	NN
10_1101-2021_01_08_423993	869	12	.	.	.
10_1101-2021_01_08_423993	870	1	PDB	PDB	NNP
10_1101-2021_01_08_423993	870	2	ID	ID	NNP
10_1101-2021_01_08_423993	870	3	6TT5	6tt5	CD
10_1101-2021_01_08_423993	870	4	7AF1	7af1	CD
10_1101-2021_01_08_423993	870	5	(	(	-LRB-
10_1101-2021_01_08_423993	870	6	2	2	CD
10_1101-2021_01_08_423993	870	7	Zn	Zn	NNP
10_1101-2021_01_08_423993	870	8	)	)	-RRB-
10_1101-2021_01_08_423993	870	9	7AFS	7afs	CD
10_1101-2021_01_08_423993	870	10	(	(	-LRB-
10_1101-2021_01_08_423993	870	11	D37A	d37a	NN
10_1101-2021_01_08_423993	870	12	)	)	-RRB-
10_1101-2021_01_08_423993	870	13	7AFU	7afu	NN
10_1101-2021_01_08_423993	870	14	(	(	-LRB-
10_1101-2021_01_08_423993	870	15	H33A	H33A	NNP
10_1101-2021_01_08_423993	870	16	)	)	-RRB-
10_1101-2021_01_08_423993	870	17	7AGI	7agi	NN
10_1101-2021_01_08_423993	870	18	(	(	-LRB-
10_1101-2021_01_08_423993	870	19	H35D	H35D	NNP
10_1101-2021_01_08_423993	870	20	)	)	-RRB-
10_1101-2021_01_08_423993	870	21	7APV	7APV	NNP
10_1101-2021_01_08_423993	870	22	7ABS	7ABS	NNP
10_1101-2021_01_08_423993	870	23	(	(	-LRB-
10_1101-2021_01_08_423993	870	24	Ni	Ni	NNP
10_1101-2021_01_08_423993	870	25	and	and	CC
10_1101-2021_01_08_423993	870	26	Zn	Zn	NNP
10_1101-2021_01_08_423993	870	27	)	)	-RRB-
10_1101-2021_01_08_423993	870	28	(	(	-LRB-
10_1101-2021_01_08_423993	870	29	Ceftriaxone	Ceftriaxone	VBN
10_1101-2021_01_08_423993	870	30	)	)	-RRB-
10_1101-2021_01_08_423993	870	31	(	(	-LRB-
10_1101-2021_01_08_423993	870	32	DNA	dna	NN
10_1101-2021_01_08_423993	870	33	bound	bind	VBN
10_1101-2021_01_08_423993	870	34	)	)	-RRB-
10_1101-2021_01_08_423993	870	35	Data	Data	NNP
10_1101-2021_01_08_423993	870	36	Collection	Collection	NNP
10_1101-2021_01_08_423993	870	37	and	and	CC
10_1101-2021_01_08_423993	870	38	processing	processing	NN
10_1101-2021_01_08_423993	870	39	Diffraction	diffraction	NN
10_1101-2021_01_08_423993	870	40	Source	source	NN
10_1101-2021_01_08_423993	870	41	DLS	DLS	NNP
10_1101-2021_01_08_423993	870	42	(	(	-LRB-
10_1101-2021_01_08_423993	870	43	I04	I04	NNP
10_1101-2021_01_08_423993	870	44	)	)	-RRB-
10_1101-2021_01_08_423993	870	45	DLS	DLS	NNP
10_1101-2021_01_08_423993	870	46	(	(	-LRB-
10_1101-2021_01_08_423993	870	47	I24	I24	NNP
10_1101-2021_01_08_423993	870	48	)	)	-RRB-
10_1101-2021_01_08_423993	870	49	DLS	DLS	NNP
10_1101-2021_01_08_423993	870	50	(	(	-LRB-
10_1101-2021_01_08_423993	870	51	I03	I03	NNP
10_1101-2021_01_08_423993	870	52	)	)	-RRB-
10_1101-2021_01_08_423993	870	53	DLS	DLS	NNP
10_1101-2021_01_08_423993	870	54	(	(	-LRB-
10_1101-2021_01_08_423993	870	55	I03	I03	NNP
10_1101-2021_01_08_423993	870	56	)	)	-RRB-
10_1101-2021_01_08_423993	870	57	DLS	DLS	NNP
10_1101-2021_01_08_423993	870	58	(	(	-LRB-
10_1101-2021_01_08_423993	870	59	I03	I03	NNP
10_1101-2021_01_08_423993	870	60	)	)	-RRB-
10_1101-2021_01_08_423993	870	61	DLS	DLS	NNP
10_1101-2021_01_08_423993	870	62	(	(	-LRB-
10_1101-2021_01_08_423993	870	63	I03	I03	NNP
10_1101-2021_01_08_423993	870	64	)	)	-RRB-
10_1101-2021_01_08_423993	870	65	APS	APS	NNP
10_1101-2021_01_08_423993	870	66	17-	17-	NNP
10_1101-2021_01_08_423993	870	67	IDD	IDD	NNP
10_1101-2021_01_08_423993	870	68	Wavelength	Wavelength	NNP
10_1101-2021_01_08_423993	870	69	(	(	-LRB-
10_1101-2021_01_08_423993	870	70	Å	å	NN
10_1101-2021_01_08_423993	870	71	)	)	-RRB-
10_1101-2021_01_08_423993	870	72	0.979	0.979	CD
10_1101-2021_01_08_423993	870	73	0.976	0.976	CD
10_1101-2021_01_08_423993	870	74	0.976	0.976	CD
10_1101-2021_01_08_423993	870	75	0.976	0.976	CD
10_1101-2021_01_08_423993	870	76	0.976	0.976	CD
10_1101-2021_01_08_423993	870	77	0.976	0.976	CD
10_1101-2021_01_08_423993	870	78	1.00	1.00	CD
10_1101-2021_01_08_423993	870	79	Space	Space	NNP
10_1101-2021_01_08_423993	870	80	group	group	NN
10_1101-2021_01_08_423993	870	81	P1	P1	NNP
10_1101-2021_01_08_423993	870	82	P1	P1	NNP
10_1101-2021_01_08_423993	870	83	P1	P1	NNP
10_1101-2021_01_08_423993	870	84	P1	P1	NNP
10_1101-2021_01_08_423993	870	85	P1	P1	NNP
10_1101-2021_01_08_423993	870	86	P1	P1	NNP
10_1101-2021_01_08_423993	870	87	P21212	P21212	NNP
10_1101-2021_01_08_423993	870	88	Cell	Cell	NNP
10_1101-2021_01_08_423993	870	89	Dimensions	Dimensions	NNP
10_1101-2021_01_08_423993	870	90	a	a	NN
10_1101-2021_01_08_423993	870	91	,	,	,
10_1101-2021_01_08_423993	870	92	b	b	NN
10_1101-2021_01_08_423993	870	93	,	,	,
10_1101-2021_01_08_423993	870	94	c	c	NN
10_1101-2021_01_08_423993	870	95	(	(	-LRB-
10_1101-2021_01_08_423993	870	96	Å	å	NN
10_1101-2021_01_08_423993	870	97	)	)	-RRB-
10_1101-2021_01_08_423993	870	98	35.87	35.87	CD
10_1101-2021_01_08_423993	870	99	,	,	,
10_1101-2021_01_08_423993	870	100	47.99	47.99	CD
10_1101-2021_01_08_423993	870	101	,	,	,
10_1101-2021_01_08_423993	870	102	48.25	48.25	CD
10_1101-2021_01_08_423993	870	103	35.75	35.75	CD
10_1101-2021_01_08_423993	870	104	,	,	,
10_1101-2021_01_08_423993	870	105	47.97,48.15	47.97,48.15	NNP
10_1101-2021_01_08_423993	870	106	35.91	35.91	CD
10_1101-2021_01_08_423993	870	107	,	,	,
10_1101-2021_01_08_423993	870	108	48.06	48.06	CD
10_1101-2021_01_08_423993	870	109	,	,	,
10_1101-2021_01_08_423993	870	110	48.21	48.21	CD
10_1101-2021_01_08_423993	870	111	35.97	35.97	CD
10_1101-2021_01_08_423993	870	112	,	,	,
10_1101-2021_01_08_423993	870	113	47.90	47.90	CD
10_1101-2021_01_08_423993	870	114	,	,	,
10_1101-2021_01_08_423993	870	115	48.37	48.37	CD
10_1101-2021_01_08_423993	870	116	35.97	35.97	CD
10_1101-2021_01_08_423993	870	117	,	,	,
10_1101-2021_01_08_423993	870	118	48.05	48.05	CD
10_1101-2021_01_08_423993	870	119	,	,	,
10_1101-2021_01_08_423993	870	120	48.44	48.44	CD
10_1101-2021_01_08_423993	870	121	35.88	35.88	CD
10_1101-2021_01_08_423993	870	122	,	,	,
10_1101-2021_01_08_423993	870	123	48.10	48.10	CD
10_1101-2021_01_08_423993	870	124	,	,	,
10_1101-2021_01_08_423993	870	125	48.25	48.25	CD
10_1101-2021_01_08_423993	870	126	72.81	72.81	CD
10_1101-2021_01_08_423993	870	127	,	,	,
10_1101-2021_01_08_423993	870	128	111.00	111.00	CD
10_1101-2021_01_08_423993	870	129	,	,	,
10_1101-2021_01_08_423993	870	130	55.17	55.17	CD
10_1101-2021_01_08_423993	870	131	α	α	XX
10_1101-2021_01_08_423993	870	132	,	,	,
10_1101-2021_01_08_423993	870	133	β	β	NNP
10_1101-2021_01_08_423993	870	134	,	,	,
10_1101-2021_01_08_423993	870	135	γ	γ	NNP
10_1101-2021_01_08_423993	870	136	(	(	-LRB-
10_1101-2021_01_08_423993	870	137	°	°	NNP
10_1101-2021_01_08_423993	870	138	)	)	-RRB-
10_1101-2021_01_08_423993	870	139	82.61	82.61	CD
10_1101-2021_01_08_423993	870	140	,	,	,
10_1101-2021_01_08_423993	870	141	76.37	76.37	CD
10_1101-2021_01_08_423993	870	142	,	,	,
10_1101-2021_01_08_423993	870	143	85.98	85.98	CD
10_1101-2021_01_08_423993	870	144	82.68	82.68	CD
10_1101-2021_01_08_423993	870	145	,	,	,
10_1101-2021_01_08_423993	870	146	76.35	76.35	CD
10_1101-2021_01_08_423993	870	147	,	,	,
10_1101-2021_01_08_423993	870	148	85.81	85.81	CD
10_1101-2021_01_08_423993	870	149	82.89	82.89	CD
10_1101-2021_01_08_423993	870	150	,	,	,
10_1101-2021_01_08_423993	870	151	76.43	76.43	CD
10_1101-2021_01_08_423993	870	152	,	,	,
10_1101-2021_01_08_423993	870	153	86.38	86.38	CD
10_1101-2021_01_08_423993	870	154	82.51	82.51	CD
10_1101-2021_01_08_423993	870	155	,	,	,
10_1101-2021_01_08_423993	870	156	75.94	75.94	CD
10_1101-2021_01_08_423993	870	157	,	,	,
10_1101-2021_01_08_423993	870	158	87.73	87.73	CD
10_1101-2021_01_08_423993	870	159	82.43,76.01	82.43,76.01	NNP
10_1101-2021_01_08_423993	870	160	,	,	,
10_1101-2021_01_08_423993	870	161	87.33	87.33	CD
10_1101-2021_01_08_423993	870	162	82.76	82.76	CD
10_1101-2021_01_08_423993	870	163	,	,	,
10_1101-2021_01_08_423993	870	164	76.29	76.29	CD
10_1101-2021_01_08_423993	870	165	,	,	,
10_1101-2021_01_08_423993	870	166	86.30	86.30	CD
10_1101-2021_01_08_423993	870	167	90.00	90.00	CD
10_1101-2021_01_08_423993	870	168	,	,	,
10_1101-2021_01_08_423993	870	169	90.00	90.00	CD
10_1101-2021_01_08_423993	870	170	,	,	,
10_1101-2021_01_08_423993	870	171	90.00	90.00	CD
10_1101-2021_01_08_423993	870	172	Resolution	Resolution	NNP
10_1101-2021_01_08_423993	870	173	(	(	-LRB-
10_1101-2021_01_08_423993	870	174	Å	å	NN
10_1101-2021_01_08_423993	870	175	)	)	-RRB-
10_1101-2021_01_08_423993	870	176	*	*	NFP
10_1101-2021_01_08_423993	870	177	47.55	47.55	CD
10_1101-2021_01_08_423993	870	178	-	-	HYPH
10_1101-2021_01_08_423993	870	179	1.50	1.50	CD
10_1101-2021_01_08_423993	870	180	47.53	47.53	CD
10_1101-2021_01_08_423993	870	181	-	-	HYPH
10_1101-2021_01_08_423993	870	182	1.70	1.70	CD
10_1101-2021_01_08_423993	870	183	35.35	35.35	CD
10_1101-2021_01_08_423993	870	184	-	-	HYPH
10_1101-2021_01_08_423993	870	185	1.70	1.70	CD
10_1101-2021_01_08_423993	870	186	35.53	35.53	CD
10_1101-2021_01_08_423993	870	187	-	-	HYPH
10_1101-2021_01_08_423993	870	188	1.56	1.56	CD
10_1101-2021_01_08_423993	870	189	47.62	47.62	CD
10_1101-2021_01_08_423993	870	190	-	-	HYPH
10_1101-2021_01_08_423993	870	191	1.70	1.70	CD
10_1101-2021_01_08_423993	870	192	47.69	47.69	CD
10_1101-2021_01_08_423993	870	193	-	-	SYM
10_1101-2021_01_08_423993	870	194	1.95	1.95	CD
10_1101-2021_01_08_423993	870	195	40	40	CD
10_1101-2021_01_08_423993	870	196	–	–	:
10_1101-2021_01_08_423993	870	197	1.97	1.97	CD
10_1101-2021_01_08_423993	870	198	(	(	-LRB-
10_1101-2021_01_08_423993	870	199	1.53	1.53	CD
10_1101-2021_01_08_423993	870	200	-	-	SYM
10_1101-2021_01_08_423993	870	201	1.50	1.50	CD
10_1101-2021_01_08_423993	870	202	)	)	-RRB-
10_1101-2021_01_08_423993	870	203	(	(	-LRB-
10_1101-2021_01_08_423993	870	204	1.73	1.73	CD
10_1101-2021_01_08_423993	870	205	-	-	SYM
10_1101-2021_01_08_423993	870	206	1.70	1.70	CD
10_1101-2021_01_08_423993	870	207	)	)	-RRB-
10_1101-2021_01_08_423993	870	208	(	(	-LRB-
10_1101-2021_01_08_423993	870	209	1.73	1.73	CD
10_1101-2021_01_08_423993	870	210	-	-	SYM
10_1101-2021_01_08_423993	870	211	1.70	1.70	CD
10_1101-2021_01_08_423993	870	212	)	)	-RRB-
10_1101-2021_01_08_423993	870	213	(	(	-LRB-
10_1101-2021_01_08_423993	870	214	1.59	1.59	CD
10_1101-2021_01_08_423993	870	215	-	-	SYM
10_1101-2021_01_08_423993	870	216	1.56	1.56	CD
10_1101-2021_01_08_423993	870	217	)	)	-RRB-
10_1101-2021_01_08_423993	870	218	(	(	-LRB-
10_1101-2021_01_08_423993	870	219	1.73	1.73	CD
10_1101-2021_01_08_423993	870	220	-	-	SYM
10_1101-2021_01_08_423993	870	221	1.70	1.70	CD
10_1101-2021_01_08_423993	870	222	)	)	-RRB-
10_1101-2021_01_08_423993	870	223	(	(	-LRB-
10_1101-2021_01_08_423993	870	224	2.00	2.00	CD
10_1101-2021_01_08_423993	870	225	-	-	SYM
10_1101-2021_01_08_423993	870	226	1.95	1.95	CD
10_1101-2021_01_08_423993	870	227	)	)	-RRB-
10_1101-2021_01_08_423993	870	228	(	(	-LRB-
10_1101-2021_01_08_423993	870	229	2.02	2.02	CD
10_1101-2021_01_08_423993	870	230	–	–	:
10_1101-2021_01_08_423993	870	231	1.97	1.97	CD
10_1101-2021_01_08_423993	870	232	)	)	-RRB-
10_1101-2021_01_08_423993	870	233	Rmerge	Rmerge	NNP
10_1101-2021_01_08_423993	870	234	(	(	-LRB-
10_1101-2021_01_08_423993	870	235	%	%	NN
10_1101-2021_01_08_423993	870	236	)	)	-RRB-
10_1101-2021_01_08_423993	870	237	*	*	NFP
10_1101-2021_01_08_423993	870	238	6.0	6.0	CD
10_1101-2021_01_08_423993	870	239	(	(	-LRB-
10_1101-2021_01_08_423993	870	240	64.4	64.4	CD
10_1101-2021_01_08_423993	870	241	)	)	-RRB-
10_1101-2021_01_08_423993	870	242	13.3	13.3	CD
10_1101-2021_01_08_423993	870	243	(	(	-LRB-
10_1101-2021_01_08_423993	870	244	79.5	79.5	CD
10_1101-2021_01_08_423993	870	245	)	)	-RRB-
10_1101-2021_01_08_423993	870	246	5.3	5.3	CD
10_1101-2021_01_08_423993	870	247	(	(	-LRB-
10_1101-2021_01_08_423993	870	248	53.2	53.2	CD
10_1101-2021_01_08_423993	870	249	)	)	-RRB-
10_1101-2021_01_08_423993	870	250	4.9	4.9	CD
10_1101-2021_01_08_423993	870	251	(	(	-LRB-
10_1101-2021_01_08_423993	870	252	31.5	31.5	CD
10_1101-2021_01_08_423993	870	253	)	)	-RRB-
10_1101-2021_01_08_423993	870	254	4.8	4.8	CD
10_1101-2021_01_08_423993	870	255	(	(	-LRB-
10_1101-2021_01_08_423993	870	256	23.2	23.2	CD
10_1101-2021_01_08_423993	870	257	)	)	-RRB-
10_1101-2021_01_08_423993	870	258	11.6	11.6	CD
10_1101-2021_01_08_423993	870	259	(	(	-LRB-
10_1101-2021_01_08_423993	870	260	65.0	65.0	CD
10_1101-2021_01_08_423993	870	261	)	)	-RRB-
10_1101-2021_01_08_423993	870	262	5.0	5.0	CD
10_1101-2021_01_08_423993	870	263	(	(	-LRB-
10_1101-2021_01_08_423993	870	264	82.8	82.8	CD
10_1101-2021_01_08_423993	870	265	)	)	-RRB-
10_1101-2021_01_08_423993	870	266	I/	I/	NNP
10_1101-2021_01_08_423993	870	267	σ(I	σ(I	,
10_1101-2021_01_08_423993	870	268	)	)	-RRB-
10_1101-2021_01_08_423993	870	269	13.4	13.4	CD
10_1101-2021_01_08_423993	870	270	(	(	-LRB-
10_1101-2021_01_08_423993	870	271	3.2	3.2	CD
10_1101-2021_01_08_423993	870	272	)	)	-RRB-
10_1101-2021_01_08_423993	870	273	5.8	5.8	CD
10_1101-2021_01_08_423993	870	274	(	(	-LRB-
10_1101-2021_01_08_423993	870	275	2.0	2.0	CD
10_1101-2021_01_08_423993	870	276	)	)	-RRB-
10_1101-2021_01_08_423993	870	277	11.7	11.7	CD
10_1101-2021_01_08_423993	870	278	(	(	-LRB-
10_1101-2021_01_08_423993	870	279	2.2	2.2	CD
10_1101-2021_01_08_423993	870	280	)	)	-RRB-
10_1101-2021_01_08_423993	870	281	11.3	11.3	CD
10_1101-2021_01_08_423993	870	282	(	(	-LRB-
10_1101-2021_01_08_423993	870	283	2.6	2.6	CD
10_1101-2021_01_08_423993	870	284	)	)	-RRB-
10_1101-2021_01_08_423993	870	285	13.4	13.4	CD
10_1101-2021_01_08_423993	870	286	(	(	-LRB-
10_1101-2021_01_08_423993	870	287	3.8	3.8	CD
10_1101-2021_01_08_423993	870	288	)	)	-RRB-
10_1101-2021_01_08_423993	870	289	8.6	8.6	CD
10_1101-2021_01_08_423993	870	290	(	(	-LRB-
10_1101-2021_01_08_423993	870	291	2.8	2.8	CD
10_1101-2021_01_08_423993	870	292	)	)	-RRB-
10_1101-2021_01_08_423993	870	293	16	16	CD
10_1101-2021_01_08_423993	870	294	(	(	-LRB-
10_1101-2021_01_08_423993	870	295	2.4	2.4	CD
10_1101-2021_01_08_423993	870	296	)	)	-RRB-
10_1101-2021_01_08_423993	870	297	Completeness	Completeness	NNP
10_1101-2021_01_08_423993	870	298	(	(	-LRB-
10_1101-2021_01_08_423993	870	299	%	%	NN
10_1101-2021_01_08_423993	870	300	)	)	-RRB-
10_1101-2021_01_08_423993	870	301	94.7	94.7	CD
10_1101-2021_01_08_423993	870	302	(	(	-LRB-
10_1101-2021_01_08_423993	870	303	66.4	66.4	CD
10_1101-2021_01_08_423993	870	304	)	)	-RRB-
10_1101-2021_01_08_423993	870	305	97.4	97.4	CD
10_1101-2021_01_08_423993	870	306	(	(	-LRB-
10_1101-2021_01_08_423993	870	307	95.6	95.6	CD
10_1101-2021_01_08_423993	870	308	)	)	-RRB-
10_1101-2021_01_08_423993	870	309	97.3	97.3	CD
10_1101-2021_01_08_423993	870	310	(	(	-LRB-
10_1101-2021_01_08_423993	870	311	96.0	96.0	CD
10_1101-2021_01_08_423993	870	312	)	)	-RRB-
10_1101-2021_01_08_423993	870	313	94.2	94.2	CD
10_1101-2021_01_08_423993	870	314	(	(	-LRB-
10_1101-2021_01_08_423993	870	315	63.7	63.7	CD
10_1101-2021_01_08_423993	870	316	)	)	-RRB-
10_1101-2021_01_08_423993	870	317	97.4	97.4	CD
10_1101-2021_01_08_423993	870	318	(	(	-LRB-
10_1101-2021_01_08_423993	870	319	95.4	95.4	CD
10_1101-2021_01_08_423993	870	320	)	)	-RRB-
10_1101-2021_01_08_423993	870	321	98.0	98.0	CD
10_1101-2021_01_08_423993	870	322	(	(	-LRB-
10_1101-2021_01_08_423993	870	323	97.2	97.2	CD
10_1101-2021_01_08_423993	870	324	)	)	-RRB-
10_1101-2021_01_08_423993	870	325	99.6	99.6	CD
10_1101-2021_01_08_423993	870	326	(	(	-LRB-
10_1101-2021_01_08_423993	870	327	99.6	99.6	CD
10_1101-2021_01_08_423993	870	328	)	)	-RRB-
10_1101-2021_01_08_423993	870	329	Multiplicity	multiplicity	NN
10_1101-2021_01_08_423993	870	330	3.6	3.6	CD
10_1101-2021_01_08_423993	870	331	(	(	-LRB-
10_1101-2021_01_08_423993	870	332	3.2	3.2	CD
10_1101-2021_01_08_423993	870	333	)	)	-RRB-
10_1101-2021_01_08_423993	870	334	3.5	3.5	CD
10_1101-2021_01_08_423993	870	335	(	(	-LRB-
10_1101-2021_01_08_423993	870	336	3.5	3.5	CD
10_1101-2021_01_08_423993	870	337	)	)	-RRB-
10_1101-2021_01_08_423993	870	338	3.6	3.6	CD
10_1101-2021_01_08_423993	870	339	(	(	-LRB-
10_1101-2021_01_08_423993	870	340	3.7	3.7	CD
10_1101-2021_01_08_423993	870	341	)	)	-RRB-
10_1101-2021_01_08_423993	870	342	3.6	3.6	CD
10_1101-2021_01_08_423993	870	343	(	(	-LRB-
10_1101-2021_01_08_423993	870	344	3.3	3.3	CD
10_1101-2021_01_08_423993	870	345	)	)	-RRB-
10_1101-2021_01_08_423993	870	346	3.7	3.7	CD
10_1101-2021_01_08_423993	870	347	(	(	-LRB-
10_1101-2021_01_08_423993	870	348	3.8	3.8	CD
10_1101-2021_01_08_423993	870	349	)	)	-RRB-
10_1101-2021_01_08_423993	870	350	3.5	3.5	CD
10_1101-2021_01_08_423993	870	351	(	(	-LRB-
10_1101-2021_01_08_423993	870	352	3.6	3.6	CD
10_1101-2021_01_08_423993	870	353	)	)	-RRB-
10_1101-2021_01_08_423993	870	354	6.4	6.4	CD
10_1101-2021_01_08_423993	870	355	(	(	-LRB-
10_1101-2021_01_08_423993	870	356	6.6	6.6	CD
10_1101-2021_01_08_423993	870	357	)	)	-RRB-
10_1101-2021_01_08_423993	870	358	Refinements	Refinements	NNPS
10_1101-2021_01_08_423993	870	359	Resolution	Resolution	NNP
10_1101-2021_01_08_423993	870	360	(	(	-LRB-
10_1101-2021_01_08_423993	870	361	Å	Å	NNP
10_1101-2021_01_08_423993	870	362	)	)	-RRB-
10_1101-2021_01_08_423993	870	363	47.55	47.55	CD
10_1101-2021_01_08_423993	870	364	-	-	HYPH
10_1101-2021_01_08_423993	870	365	1.50	1.50	CD
10_1101-2021_01_08_423993	870	366	47.53	47.53	CD
10_1101-2021_01_08_423993	870	367	-	-	HYPH
10_1101-2021_01_08_423993	870	368	1.70	1.70	CD
10_1101-2021_01_08_423993	870	369	47.66	47.66	CD
10_1101-2021_01_08_423993	870	370	-	-	HYPH
10_1101-2021_01_08_423993	870	371	1.70	1.70	CD
10_1101-2021_01_08_423993	870	372	35.53	35.53	CD
10_1101-2021_01_08_423993	870	373	-	-	HYPH
10_1101-2021_01_08_423993	870	374	1.56	1.56	CD
10_1101-2021_01_08_423993	870	375	47.62	47.62	CD
10_1101-2021_01_08_423993	870	376	-	-	HYPH
10_1101-2021_01_08_423993	870	377	1.70	1.70	CD
10_1101-2021_01_08_423993	870	378	47.96	47.96	CD
10_1101-2021_01_08_423993	870	379	-	-	SYM
10_1101-2021_01_08_423993	870	380	1.95	1.95	CD
10_1101-2021_01_08_423993	870	381	40	40	CD
10_1101-2021_01_08_423993	870	382	-	-	SYM
10_1101-2021_01_08_423993	870	383	1.97	1.97	CD
10_1101-2021_01_08_423993	870	384	No	no	NN
10_1101-2021_01_08_423993	870	385	.	.	.
10_1101-2021_01_08_423993	871	1	of	of	IN
10_1101-2021_01_08_423993	871	2	reflections	reflection	NNS
10_1101-2021_01_08_423993	871	3	44746	44746	CD
10_1101-2021_01_08_423993	871	4	31282	31282	CD
10_1101-2021_01_08_423993	871	5	34470	34470	CD
10_1101-2021_01_08_423993	871	6	39478	39478	CD
10_1101-2021_01_08_423993	871	7	31745	31745	CD
10_1101-2021_01_08_423993	871	8	21086	21086	CD
10_1101-2021_01_08_423993	871	9	32168	32168	CD
10_1101-2021_01_08_423993	871	10	Rwork	Rwork	NNP
10_1101-2021_01_08_423993	871	11	0.17	0.17	CD
10_1101-2021_01_08_423993	871	12	0.19	0.19	CD
10_1101-2021_01_08_423993	871	13	0.18	0.18	CD
10_1101-2021_01_08_423993	871	14	0.19	0.19	CD
10_1101-2021_01_08_423993	871	15	0.19	0.19	CD
10_1101-2021_01_08_423993	871	16	0.18	0.18	CD
10_1101-2021_01_08_423993	871	17	0.22	0.22	CD
10_1101-2021_01_08_423993	871	18	Rfree	Rfree	NNP
10_1101-2021_01_08_423993	871	19	0.19	0.19	CD
10_1101-2021_01_08_423993	871	20	0.21	0.21	CD
10_1101-2021_01_08_423993	871	21	0.22	0.22	CD
10_1101-2021_01_08_423993	871	22	0.21	0.21	CD
10_1101-2021_01_08_423993	871	23	0.21	0.21	CD
10_1101-2021_01_08_423993	871	24	0.23	0.23	CD
10_1101-2021_01_08_423993	871	25	0.28	0.28	CD
10_1101-2021_01_08_423993	871	26	No	no	UH
10_1101-2021_01_08_423993	871	27	.	.	.
10_1101-2021_01_08_423993	872	1	of	of	IN
10_1101-2021_01_08_423993	872	2	Atom	Atom	NNP
10_1101-2021_01_08_423993	872	3	Protein	Protein	NNP
10_1101-2021_01_08_423993	872	4	2927	2927	CD
10_1101-2021_01_08_423993	872	5	2989	2989	CD
10_1101-2021_01_08_423993	872	6	2957	2957	CD
10_1101-2021_01_08_423993	872	7	2985	2985	CD
10_1101-2021_01_08_423993	872	8	3122	3122	CD
10_1101-2021_01_08_423993	872	9	2975	2975	CD
10_1101-2021_01_08_423993	872	10	2923	2923	CD
10_1101-2021_01_08_423993	872	11	Water	Water	NNP
10_1101-2021_01_08_423993	872	12	224	224	CD
10_1101-2021_01_08_423993	872	13	144	144	CD
10_1101-2021_01_08_423993	872	14	163	163	CD
10_1101-2021_01_08_423993	872	15	255	255	CD
10_1101-2021_01_08_423993	872	16	164	164	CD
10_1101-2021_01_08_423993	872	17	107	107	CD
10_1101-2021_01_08_423993	872	18	105	105	CD
10_1101-2021_01_08_423993	872	19	Zinc/	zinc/	NN
10_1101-2021_01_08_423993	872	20	Nickle	Nickle	NNP
10_1101-2021_01_08_423993	872	21	3	3	CD
10_1101-2021_01_08_423993	872	22	3	3	CD
10_1101-2021_01_08_423993	872	23	2	2	CD
10_1101-2021_01_08_423993	872	24	1	1	CD
10_1101-2021_01_08_423993	872	25	1	1	CD
10_1101-2021_01_08_423993	872	26	2	2	CD
10_1101-2021_01_08_423993	872	27	3	3	CD
10_1101-2021_01_08_423993	872	28	Ethylene	Ethylene	NNP
10_1101-2021_01_08_423993	872	29	glycol	glycol	NN
10_1101-2021_01_08_423993	872	30	24	24	CD
10_1101-2021_01_08_423993	872	31	28	28	CD
10_1101-2021_01_08_423993	872	32	12	12	CD
10_1101-2021_01_08_423993	872	33	44	44	CD
10_1101-2021_01_08_423993	872	34	32	32	CD
10_1101-2021_01_08_423993	872	35	16	16	CD
10_1101-2021_01_08_423993	872	36	-	-	HYPH
10_1101-2021_01_08_423993	872	37	DNA	dna	NN
10_1101-2021_01_08_423993	872	38	-	-	HYPH
10_1101-2021_01_08_423993	872	39	-	-	HYPH
10_1101-2021_01_08_423993	872	40	-	-	HYPH
10_1101-2021_01_08_423993	872	41	-	-	HYPH
10_1101-2021_01_08_423993	872	42	-	-	HYPH
10_1101-2021_01_08_423993	872	43	-	-	HYPH
10_1101-2021_01_08_423993	872	44	253	253	CD
10_1101-2021_01_08_423993	872	45	Ceftriaxone	Ceftriaxone	VBN
10_1101-2021_01_08_423993	872	46	-	-	HYPH
10_1101-2021_01_08_423993	872	47	̶	̶	NNP
10_1101-2021_01_08_423993	872	48	-	-	HYPH
10_1101-2021_01_08_423993	872	49	-	-	:
10_1101-2021_01_08_423993	872	50	-	-	HYPH
10_1101-2021_01_08_423993	872	51	1	1	CD
10_1101-2021_01_08_423993	872	52	-	-	HYPH
10_1101-2021_01_08_423993	872	53	B	b	NN
10_1101-2021_01_08_423993	872	54	-	-	HYPH
10_1101-2021_01_08_423993	872	55	factors	factor	NNS
10_1101-2021_01_08_423993	872	56	16.3	16.3	CD
10_1101-2021_01_08_423993	872	57	19.3	19.3	CD
10_1101-2021_01_08_423993	872	58	25.9	25.9	CD
10_1101-2021_01_08_423993	872	59	17.5	17.5	CD
10_1101-2021_01_08_423993	872	60	18.4	18.4	CD
10_1101-2021_01_08_423993	872	61	22.6	22.6	CD
10_1101-2021_01_08_423993	872	62	56	56	CD
10_1101-2021_01_08_423993	872	63	r.m.s	r.m.s	NN
10_1101-2021_01_08_423993	872	64	.	.	.
10_1101-2021_01_08_423993	873	1	deviations	deviation	NNS
10_1101-2021_01_08_423993	873	2	Bond	Bond	NNP
10_1101-2021_01_08_423993	873	3	length	length	NN
10_1101-2021_01_08_423993	873	4	(	(	-LRB-
10_1101-2021_01_08_423993	873	5	Å	å	NN
10_1101-2021_01_08_423993	873	6	)	)	-RRB-
10_1101-2021_01_08_423993	873	7	0.003	0.003	CD
10_1101-2021_01_08_423993	873	8	0.008	0.008	CD
10_1101-2021_01_08_423993	873	9	0.008	0.008	CD
10_1101-2021_01_08_423993	873	10	0.006	0.006	CD
10_1101-2021_01_08_423993	873	11	0.007	0.007	CD
10_1101-2021_01_08_423993	873	12	0.01	0.01	CD
10_1101-2021_01_08_423993	873	13	0.007	0.007	CD
10_1101-2021_01_08_423993	873	14	bond	bond	NN
10_1101-2021_01_08_423993	873	15	angles	angle	NNS
10_1101-2021_01_08_423993	873	16	(	(	-LRB-
10_1101-2021_01_08_423993	873	17	°	°	NNP
10_1101-2021_01_08_423993	873	18	)	)	-RRB-
10_1101-2021_01_08_423993	873	19	1.23	1.23	CD
10_1101-2021_01_08_423993	873	20	1.33	1.33	CD
10_1101-2021_01_08_423993	873	21	1.29	1.29	CD
10_1101-2021_01_08_423993	873	22	1.28	1.28	CD
10_1101-2021_01_08_423993	873	23	1.32	1.32	CD
10_1101-2021_01_08_423993	873	24	1.5	1.5	CD
10_1101-2021_01_08_423993	873	25	1.47	1.47	CD
10_1101-2021_01_08_423993	873	26	.CC	.CC	NFP
10_1101-2021_01_08_423993	873	27	-	-	:
10_1101-2021_01_08_423993	873	28	BY	by	IN
10_1101-2021_01_08_423993	873	29	4.0	4.0	CD
10_1101-2021_01_08_423993	873	30	International	international	JJ
10_1101-2021_01_08_423993	873	31	licensemade	licensemade	NN
10_1101-2021_01_08_423993	873	32	available	available	JJ
10_1101-2021_01_08_423993	873	33	under	under	IN
10_1101-2021_01_08_423993	873	34	a	a	DT
10_1101-2021_01_08_423993	873	35	(	(	-LRB-
10_1101-2021_01_08_423993	873	36	which	which	WDT
10_1101-2021_01_08_423993	873	37	was	be	VBD
10_1101-2021_01_08_423993	873	38	not	not	RB
10_1101-2021_01_08_423993	873	39	certified	certify	VBN
10_1101-2021_01_08_423993	873	40	by	by	IN
10_1101-2021_01_08_423993	873	41	peer	peer	NN
10_1101-2021_01_08_423993	873	42	review	review	NN
10_1101-2021_01_08_423993	873	43	)	)	-RRB-
10_1101-2021_01_08_423993	873	44	is	be	VBZ
10_1101-2021_01_08_423993	873	45	the	the	DT
10_1101-2021_01_08_423993	873	46	author	author	NN
10_1101-2021_01_08_423993	873	47	/	/	SYM
10_1101-2021_01_08_423993	873	48	funder	funder	NN
10_1101-2021_01_08_423993	873	49	,	,	,
10_1101-2021_01_08_423993	873	50	who	who	WP
10_1101-2021_01_08_423993	873	51	has	have	VBZ
10_1101-2021_01_08_423993	873	52	granted	grant	VBN
10_1101-2021_01_08_423993	873	53	bioRxiv	biorxiv	IN
10_1101-2021_01_08_423993	873	54	a	a	DT
10_1101-2021_01_08_423993	873	55	license	license	NN
10_1101-2021_01_08_423993	873	56	to	to	TO
10_1101-2021_01_08_423993	873	57	display	display	VB
10_1101-2021_01_08_423993	873	58	the	the	DT
10_1101-2021_01_08_423993	873	59	preprint	preprint	NN
10_1101-2021_01_08_423993	873	60	in	in	IN
10_1101-2021_01_08_423993	873	61	perpetuity	perpetuity	NN
10_1101-2021_01_08_423993	873	62	.	.	.
10_1101-2021_01_08_423993	874	1	It	-PRON-	PRP
10_1101-2021_01_08_423993	874	2	is	be	VBZ
10_1101-2021_01_08_423993	874	3	The	the	DT
10_1101-2021_01_08_423993	874	4	copyright	copyright	NN
10_1101-2021_01_08_423993	874	5	holder	holder	NN
10_1101-2021_01_08_423993	874	6	for	for	IN
10_1101-2021_01_08_423993	874	7	this	this	DT
10_1101-2021_01_08_423993	874	8	preprintthis	preprintthis	NN
10_1101-2021_01_08_423993	874	9	version	version	NN
10_1101-2021_01_08_423993	874	10	posted	post	VBD
10_1101-2021_01_08_423993	874	11	January	January	NNP
10_1101-2021_01_08_423993	874	12	8	8	CD
10_1101-2021_01_08_423993	874	13	,	,	,
10_1101-2021_01_08_423993	874	14	2021	2021	CD
10_1101-2021_01_08_423993	874	15	.	.	.
10_1101-2021_01_08_423993	874	16	;	;	:
10_1101-2021_01_08_423993	874	17	https://doi.org/10.1101/2021.01.08.423993doi	https://doi.org/10.1101/2021.01.08.423993doi	NNP
10_1101-2021_01_08_423993	874	18	:	:	:
10_1101-2021_01_08_423993	874	19	bioRxiv	biorxiv	VB
10_1101-2021_01_08_423993	874	20	preprint	preprint	NN
10_1101-2021_01_08_423993	874	21	https://doi.org/10.1101/2021.01.08.423993	https://doi.org/10.1101/2021.01.08.423993	ADD
10_1101-2021_01_08_423993	874	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD