id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-021079-m6nbs2c0	Yong, Voon Wee	Major histocompatibility complex molecules on glial cells	2004-11-23		.txt	text/plain	5286	255	38	While glial cells of the central nervous system do not constitutively express class I or II major histocompatibility complex (MHC) molecules, astrocytes and microglial cells can be induced by a variety of factors to express these antigens. 17 The majority of rat CNS cells newly induced to express MHC class II following 3 days of continuous intravenous administration of gamma-interferon, which is a potent inducer of class II antigens on astrocytes in vitro (see below), were found to be microglia and not astrocytes . There does not appear to be changes in MHC expression due to age factors, from the limited number of studies currently available, 23 , 48, 49 Significance of MHC expression by glial cells Antigen presentation Neonatal murine astrocytes and microglia, especially after gamma-interferon treatment, can present antigen, e .g. myelin basic protein, to previously sensitized CD4+ T cell lines in an MHC class IIrestricted manner .	./cache/cord-021079-m6nbs2c0.txt	./txt/cord-021079-m6nbs2c0.txt