id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268238-ipfs7hcb	Mathieu, Patricia A.	Sequence similarity and structural homologies are involved in the autoimmune response elicited by mouse hepatitis virus A59	2004-07-17		.txt	text/plain	4527	228	53	The features of autoantibodies (autoAb) to liver fumarylacetoacetate hydrolase (FAH) elicited in mice infected with mouse hepatitis virus (MHV) were studied by ELISA and western-blot competition assays. ELISA and western-blot competition assays, as well as Ab reactivity with synthetic peptides from both FAH and viral proteins, indicated that the autoAb recognized a wide range of cryptic and conformational epitopes of the antigen and that the cross-reaction showed by the anti-MHV Ab could be different between individuals. Results obtained with sera from five BALB/c and three CBA/Ht mice showed that the enzyme did not compete for Ab binding to MHV neither in ELISA nor in western-blot competition assays, suggesting that the anti-MHV Ab did not recognize the native epitopes exposed in the soluble autoAg (see representative results in Fig. 2) .	./cache/cord-268238-ipfs7hcb.txt	./txt/cord-268238-ipfs7hcb.txt