id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305341-nokybn2a	Zeng, Fanya	Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments	2004-03-19		.txt	text/plain	3954	192	51	title: Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments Another interesting finding was that mouse antibodies elicited separately by plasmids encoding S1 and S2 subunits cooperatively neutralized SARS-CoV but neither the S1 nor S2 specific antibodies did, suggesting the possible role of both S1 and S2 subunits in host cell docking and entry. Animals vaccinated with DNA encoding secreting form of E2 glycoprotein of classical swine fever virus (CSFV) showed both CSFV specific antibody response and protection upon viral challenge though the native E2 was anchor membrane protein ( [28, 29] and Zeng et al., unpublished data). In the mice experiment, it was demonstrated that SARS-CoV specific antibodies could be induced by immunization with plasmids encoding S1, S2 and fragment of S1 subunit. The first paper on immunizing masques with structural genes of SARS-CoV, however, reported that co-delivery of three viral genes encoding S1, nucleocapsid (N), and membrane (M) protein could elicit a high titer of neutralizing antibody and T-cell response [24] .	./cache/cord-305341-nokybn2a.txt	./txt/cord-305341-nokybn2a.txt