id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312865-nno2yjae	Sylvester‐Hvid, C.	SARS CTL vaccine candidates; HLA supertype‐, genome‐wide scanning and biochemical validation	2004-04-23		.txt	text/plain	2118	114	45	One would therefore expect that an effective vaccine should induce mucosal immunity such as that effected by secretory immunoglobulin A (IgA), which specifically prevents an infectious agent from penetrating the mucosal epithelium, and by cytotoxic T lymphocytes (CTLs), which specifically eradicate infected cells (5) . Human CTLs are specific for peptides presented in the context of human leukocyte antigen (HLA) molecules [generically known as ''major histocompatibility complex (MHC) molecules'']. Thus, 13 of the 15 peptides predicted to be good binders to A*0301 were found to bind to another member of the A3 supertype, HLA-A*1101. Similarly, nine of the 15 peptides predicted to be good binders to A*1101 were found to bind to HLA-A*0301 (Table 1) Once all nine supertypes have been tested, we would project to have found well over 100 different vaccine candidates. Immunogenicity of a human immunodeficiency virus (HIV) polytope vaccine containing multiple HLA A2 HIV CD8(þ) cytotoxic T-cell epitopes	./cache/cord-312865-nno2yjae.txt	./txt/cord-312865-nno2yjae.txt