id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-330558-autprmr4	Burrell, Louise M.	ACE2, a new regulator of the renin–angiotensin system	2004-05-31		.txt	text/plain	2864	131	47	Ang II is thought to be responsible for most of the physiological and pathophysiological effects of the RAS, and inhibitors of ACE that reduce the formation of Ang II have been highly successful in the management of hypertension, are standard therapy following myocardial infarction to delay the development of heart failure, and reduce the rate of progression of renal disease [2, 3] . Recently, however, the classical view of the RAS has been challenged by the discovery of the enzyme ACE2 [4, 5] , in addition to the increasing awareness that many angiotensin peptides other than Ang II have biological activity and physiological importance [6] . Blockade of the RAS with ACE inhibitors or Ang II type 1 receptor antagonists has clearly established its key role in the pathophysiology of an increasing number of diseases, including hypertension, heart failure, ventricular remodelling, renoprotection and diabetic complications.	./cache/cord-330558-autprmr4.txt	./txt/cord-330558-autprmr4.txt