id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-351354-10rusr6j	Chan, Louis Y.	Diagnostic Criteria during SARS Outbreak in Hong Kong	2004-06-17		.txt	text/plain	1947	104	54	Before the etiologic agent was identified, the diagnosis of SARS was made according to a set of clinical-epidemiologic criteria as suggested by the Centers for Disease Control and Prevention (CDC) (1-3). These criteria remained important in the initial diagnosis and prompt isolation of patients because the overall sensitivity of initial reverse transcriptase-polymerase chain reaction (RT-PCR) testing for SARSassociated coronavirus (SARS CoV) RNA on upper respiratory specimens ranged from approximately 60% to 70% (though sensitivity improved with a second test) (4, 5) . By using paired serologic testing to determine SARS-CoV infection (3), we evaluated the relative importance of the clinical-epidemiologic diagnostic criteria during an outbreak. Probable SARS case-patients were those who met the CDC clinical criteria for severe respiratory illness of unknown etiology (3), and met the epidemiologic criterion for exposure in either a close or a possible contact. Our findings showed that 5.9% of cases defined as probable SARS on the basis of clinical-epidemiologic criteria had no serologic evidence of coronavirus infection.	./cache/cord-351354-10rusr6j.txt	./txt/cord-351354-10rusr6j.txt