id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255158-cxt824rp	Zheng, Li-Zhen	Src siRNA prevents corticosteroid-associated osteoporosis in a rabbit model	2015-11-18		.txt	text/plain	4731	231	45	In a modified SAON rabbit model, we found destructive repair at subchondral region of femoral head, i.e. a dominate old bone resorption without adequate new bone formation to maintain normal bone homeostasis; and knockdown of Src expression by Src specific siRNA could enhance osteoblast differentiation, promote osteogenesis and inhibit the function of osteoclasts [14] . In this study, we investigated corticosteroid-associated bone loss at metaphysis of femoral head using an established SAON rabbit model [14] and potential effects of Src siRNA for prevention of SAOP. This study investigated the bone loss induced by pulsed LPS and MPS using an established SAON rabbit model and tested the therapeutic potential of Src siRNA, a bone anabolic and anti-resorption agent for prevention of corticosteroid associated osteoporosis (SAOP). The loss of trabecular bone at metaphysis of femoral head after pulsed LPS and MPS treatment was reversed by Src siRNA administration in the present study, with significantly better micro-CT indices, including BMD, BV/TV, Tb. Th and Conn.	./cache/cord-255158-cxt824rp.txt	./txt/cord-255158-cxt824rp.txt