id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-331361-pd9lt4n2	Mathieu, Cyrille	Heparan Sulfate-Dependent Enhancement of Henipavirus Infection	2015-03-10		.txt	text/plain	5837	291	49	Furthermore, heparin was able to inhibit the interaction of the viruses with the heparan sulfate and to block cell-mediated trans-infection of henipaviruses. Strikingly, heparin was also active when applied after contact with the virus, and both pretreatment and posttreatment with heparin were effective in inhibiting human PBL-mediated trans-infection of either NiV or HeV (Fig. 2B ). Heparin treatment modestly, but significantly, reduced the percentage of infected cells from both cell lines, indicating that this molecule may also directly inhibit or delay the binding of NiV to its entry receptors EFN-B2 and -B3. Nipah virus (isolate UMMC1; Gen-Bank accession number AY029767) (42), recombinant NiV expressing enhanced green fluorescent protein (45) , and Hendra virus (Australia/ horse/1994) obtained from Porton Down Laboratory, United Kingdom, were prepared on Vero-E6 cells as described previously (46) , and infection virus was used in the INSERM Jean Mérieux BSL4 laboratory in Lyon, France.	./cache/cord-331361-pd9lt4n2.txt	./txt/cord-331361-pd9lt4n2.txt