id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002932-5e7xrd1y	Watanabe, Tokiko	Experimental infection of Cynomolgus Macaques with highly pathogenic H5N1 influenza virus through the aerosol route	2018-03-19		.txt	text/plain	4497	212	44	In the ferret model, these studies demonstrated that the inoculation of animals with highly pathogenic avian influenza H5N1 virus via the aerosol route led to higher nasal wash virus titers, earlier onset of clinical signs, and/or a broader spectrum of disease compared with infection via intranasal inoculation despite no difference in lethality [9] [10] [11] . On day 3 post-infection, VN3040 virus was recovered from nasal swabs of two and three animals in the conventional and aerosol method groups, respectively, and the mean virus titers were comparable between the two groups. Cynomolgus macaques were inoculated with 4 ml of a 10 7 PFU/ml solution of the highly pathogenic H5N1 avian influenza virus A/Vietnam/ UT3040/2004 strain (VN3040) through the aerosol route by using the ultrasonic nebulizer NE-U17 (defined as "the aerosol method group"). In contrast, VN3040 replicated well in the right-and left-lower lung lobes of the infected animals in the conventional method group [the virus mean titers were 3.51 and 4.75 log 10 (PFU/g), respectively].	./cache/cord-002932-5e7xrd1y.txt	./txt/cord-002932-5e7xrd1y.txt