id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002957-gw2cow0d	Gray, Darren W.	DIVA metabolomics: Differentiating vaccination status following viral challenge using metabolomic profiles	2018-04-05		.txt	text/plain	7426	323	36	The aims of the current study were therefore to assess the performance of Reverse Phase (RP) and Hydrophobic Interaction Liquid Chromatography (HILIC) separation methods for Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) metabolomic profiling of bovine plasma and identify plasma metabolomic markers capable of differentiating between vaccinated and nonvaccinated calves following intranasal challenge with BPI3V. The selected panel of 383 unique AMRTPs (S3 Table) differentiating animals of different vaccination status at various time-points post-BPI3V challenge were deconvoluted to identify parent ion mass, adducts and low energy fragments using low and high energy data (Function 1 and 2 respectively), yielding 26 parent ions for elemental composition determination. The metabolomic profiling performed here in this study on post-BPI3V challenge acquired samples, has identified a unique panel of plasma metabolites which differ between vaccinated and non-vaccinated animals, and significantly are involved in recognised immune response mechanisms.	./cache/cord-002957-gw2cow0d.txt	./txt/cord-002957-gw2cow0d.txt