id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002967-yy3bennu	Penna, Fabio	Modulating Metabolism to Improve Cancer-Induced Muscle Wasting	2018-01-29		.txt	text/plain	6773	341	36	Modulations of the ubiquitinproteasome proteolytic system, however, are not a general finding in cancer cachexia, as shown by studies reporting that it is not differently activated with respect to controls in the muscle of patients affected by non-small-cell lung cancer (NSCLC; [11] ) or esophageal cancer [12] . Finally, carfilzomib, an irreversible selective inhibitor of proteasome chymotrypsin-like activity, was shown to improve cachexia in tumor-bearing mice by inhibiting muscle protein breakdown [31] . Glutamine supplementation was reported to attenuate muscle protein wasting in cancer patients [68] , as well as to improve the energy balance in rats bearing the Walker 256 tumor [69] . Last but not least, treatments aimed at preventing/correcting the metabolic alterations underlying cancer-induced muscle wasting might also impinge on tumor-targeted therapies improving their effectiveness and/ or enhancing patient tolerance to chemotherapy.	./cache/cord-002967-yy3bennu.txt	./txt/cord-002967-yy3bennu.txt