id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003254-yiqdsf9z	Schlub, Timothy E	A Simple Method to Detect Candidate Overlapping Genes in Viruses Using Single Genome Sequences	2018-08-07		.txt	text/plain	6313	292	49	Herein, we present a new statistical method for detecting overlapping genes in different reading frames that relies on only a single nucleotide sequence of a gene or genome. For the synonymous mutation test (C), codons that preserve the original amino acid sequence are randomly generated and the length of ORFs on alternative reading frames subsequently measured (note that codon replacement is not restricted to the example mutations shown in the figure, all of which occur in the third nucleotide positions, and that codon replacement with the original codon is also possible). Accordingly, whole genome sequences were downloaded from 2548 reference linear RNA viruses available on GenBank; this produced a total of 6408 coding regions that were used to estimate the sensitivity and false discovery rate of each test. where C is the empirical cumulative distribution function of the theoretical distribution of lengths calculated by permuting codons in the original coding sequence: that is, C(L) is the Simple Method to Detect Candidate Overlapping Genes .	./cache/cord-003254-yiqdsf9z.txt	./txt/cord-003254-yiqdsf9z.txt