id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003602-wtestt8i	Jung, Eunok	Strategies in regulating glioblastoma signaling pathways and anti-invasion therapy	2019-04-22		.txt	text/plain	8897	460	45	In this work, optimal control theory was applied to regulate intracellular signaling pathways of miR-451–AMPK–mTOR–cell cycle dynamics via glucose and drug intravenous administration infusions. The core control system predicts bistability and hysteresis bifurcation when delayed down-regulation of miR-451 activities along certain molecular pathways would induce glioma cells to stay longer in the proliferative phase despite relatively low glucose concentrations, making this mechanism a therapeutic target. In the current investigation, we aim to regulate the amount of glucose and drug infusions to up-regulate miR-451 and mTOR above its threshold values inducing cell proliferation Strategies in regulating glioblastoma signaling pathways and anti-invasion therapy avoiding migration to neighboring tissues. The mutual antagonistic mechanism Strategies in regulating glioblastoma signaling pathways and anti-invasion therapy between miR-451 (mTOR) and AMPK complex and the cell's strategic metabolic adaptation support the survival of cancer cells even in a nutrient-deprived microenvironment [14, 55] .	./cache/cord-003602-wtestt8i.txt	./txt/cord-003602-wtestt8i.txt