id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004058-j11yaga2	Meyerholz, David K	Fundamental Concepts for Semiquantitative Tissue Scoring in Translational Research	2018-01-01		.txt	text/plain	3513	206	34	Reproducibility can be improved by constraining bias through appropriate experimental design, randomization of tissues, effective use of multidisciplinary collaborations, and valid masking procedures. Following key principles of semiquantitative scoring will not only enhance descriptive tissue evaluation but also improve quality, reproducibility, and rigor of tissue studies. Semiquantitative scoring can be applied to macroscopic and microscopic tissue changes, allowing generation of robust data that are amenable to statistical analysis and evaluation of experimental groups. [3] [4] [5] [6] [7] [8] In the preclinical area, which utilizes models (eg, animal, tissue/cell cultures, etc.) of human diseases/conditions, semiquantitative scoring is regularly used to compare experimental groups. 33, 34 Specifically, statistical and pathological analyses are common components in translational studies, but trained statisticians and board-certified pathologists are often omitted from these multidisciplinary teams, leading to data interpretations that are more prone to errors.	./cache/cord-004058-j11yaga2.txt	./txt/cord-004058-j11yaga2.txt