id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011189-c0ytamge	da Fonseca Pestana Ribeiro, Jose Mauro	Less empiric broad-spectrum antibiotics is more in the ICU	2019-11-27		.txt	text/plain	1621	81	29	The real impact of MDRs on the outcomes of ICU patients is debatable, but despite this controversy, the incidence of MDRs is related to poor quality-of-care, as an expression of reduced compliance to hand hygiene [14] , and a high burden of antibiotic exposure [15] . De-escalation decreases the time of antibiotic use, but a short exposure still exists; in this way, a single antibiotic dose may be enough to treat severe infections such as Fig. 1 Two different mindsets in the decision making process to initiate antibiotics to critically ill patients who are getting worse. Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensivecare-unit-acquired infection: a quasi-experimental, before and after observational cohort study	./cache/cord-011189-c0ytamge.txt	./txt/cord-011189-c0ytamge.txt