id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011318-lw9vluxm	Avila-Calderón, Eric Daniel	Dendritic cells and Brucella spp. interaction: the sentinel host and the stealthy pathogen	2019-02-19		.txt	text/plain	10055	541	49	Inside host cells, especially DCs, Brucella modulates the expression of surface molecules related to maturation, costimulation, migration and/or Ag presentation, as well as influences cytokine production (Billard et al. In a comparative study, human monocyte-derived GM-DCs were infected with different intracellular bacterial pathogens: Orientia tsutsugamushi the etiologic agent of scrub typhus, Coxiella burnetii responsible for Q fever, and Brucella. Despite the impaired GM-DC maturation observed in the experiments of Billard et al., Brucella infection was slightly detected based on the immune response, since low cytokine levels were induced. abortus 2308 (1000 bacteria/cell) to infect murine DCs, observing upregulation of costimulatory molecules, as well as significant cytokine production. With the exception of bovine-derived DCs, this pathogen infects and replicates inside DCs. Brucella recognition at the outside of the eukaryotic cell is mediated by TLRs and signaling triggers the immune response, as shown by cytokine production. Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection	./cache/cord-011318-lw9vluxm.txt	./txt/cord-011318-lw9vluxm.txt