id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012374-excn1a10	Han, Xiaoqing	CXCR2 expression on granulocyte and macrophage progenitors under tumor conditions contributes to mo-MDSC generation via SAP18/ERK/STAT3	2019-08-08		.txt	text/plain	8058	488	54	The increase of SAP18 expression inhibited the ERK/STAT3 signaling pathway, which regulates the differentiation of HSPCs into mo-MDSCs. Thus, these findings reveal a novel role for CXCR2 through which SAP18/ERK/STAT3 signaling regulates hematopoietic cells differentiation in the tumor microenvironment. A one-way ANOVA with repeated measures followed by a Dunnett's post hoc test or a two-way ANOVA followed by Holm-Sidak's post hoc test were used to determine the level of statistical significance (*p < 0.05; **p < 0.01; and ***p < 0.001; ns, not significant) Fig. 2 CXCR2 deficiency impairs the differentiation of myeloid progenitor cells into mo-MDSCs. a The percentage of mo-MDSCs and G-MDSCs induced from WT or CXCR2−/− bone marrow cells were detected by flow cytometry. The results showed that knocking down SAP18 in CXCR2−/− tumor-bearing mice increased the percentage of the genes that are consistently 1.5-fold upregulated or two-fold downregulated in 32D clone three cells transfected with CXCR2 or the empty vector, and both cells were incubated with CXCL1 and CXCL2 for 4 h.	./cache/cord-012374-excn1a10.txt	./txt/cord-012374-excn1a10.txt