id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012654-m8nlsutd	Song, Zhiquan	Genome-wide identification of DNA-PKcs-associated RNAs by RIP-Seq	2019-07-05		.txt	text/plain	622	39	54	Regulation of RNA alternative splicing is a crucial process in RNA-binding proteins function, and aberrant splicing is often associated with various human diseases including cancers; 8 therefore, to discern how DNA-PKcs modulates bound RNAs, we sought to determine whether DNA-PKcs could affect CD44 alternative splicing. Specific primers to amplify the CD44 standard sequence and variants were designed, and qPCR was performed to examine the expression of different variants after U2OS cells were treated with NU7441 and NU7026, which target DNA-PKcs. The results showed that V4, V9, and V10 increased. In summary, our findings strongly support a model wherein the DNA-PKcs protein controls a variety of biological processes, including alternative splicing, through its RNA-binding activity. The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1 Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer	./cache/cord-012654-m8nlsutd.txt	./txt/cord-012654-m8nlsutd.txt