id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017142-vx3rgs4r	Nair, Ranjit	What the Intensivists Need to Know About Critically Ill Myeloma Patients	2019-07-09		.txt	text/plain	9343	460	36	Suspicion of cast nephropathy in newly diagnosed myeloma patients with serum FLC above 1000 mg/L should be high, especially if associated selective proteinuria composed of FLC/BJP exists, as the degree of renal injury is usually related to tumor load [55] . MM patients are at high risk for cardiac complications secondary multiple factors including an older age group of patients with underlying comorbidities, concurrent kidney involvement, MM-associated deposition disease, and/or anti-MM drug-related side effects. Cardiac amyloidosis can be clinically silent initially, and a MM patient presenting with progressive dyspnea, worsening edema with evidence of heart failure, or dysrhythmia presenting as syncope or hypotensive event requires a thorough work-up to rule out coexisting amyloid disease. Immunosuppression is mediated by disease-and treatment-related factors including decreased ratio of functional to dysfunctional immunoglobulins, defects in antibody opsonization, steroid-related T cell defects, secondary immunodeficiency related to chemotherapy, restricted pulmonary reserve from thoracic rib fractures and opiate use, mucosal damage, indwelling catheters, and presence of renal failure [53, 88, 100] .	./cache/cord-017142-vx3rgs4r.txt	./txt/cord-017142-vx3rgs4r.txt