id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017887-pj6pal35	OuYang, Bo	Structural and Functional Properties of Viral Membrane Proteins	2018-06-29		.txt	text/plain	11512	560	48	Functional mutagenesis studies have suggested that, at least in the cases of HIV-1 and influenza A viruses, the TM domains (TMDs) of fusion proteins are not merely membrane anchors, but play important roles in membrane fusion and viral infectivity. Apart from the channels and fusion proteins, some viruses have developed enzymatic domains anchored to the membrane, e.g., the polymerases of the hepatitis C virus and the neurominidase of the influenza viruses. Unlike many other broad-spectrum antivirals, Arbidol has an established mechanism of action against the HAs in influenza A and B viruses that involves the inhibition of virus-mediated membrane fusion and thus viral entry [50] . The NMR structure of the HIV-1 Env TMD may provide some clues for how other viral fusion proteins oligomerize in the membrane. Influenza B virus BM2 protein has ion channel activity that conducts protons across membranes	./cache/cord-017887-pj6pal35.txt	./txt/cord-017887-pj6pal35.txt