id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-023202-0iqhf2o5	MacRaild, Christopher A.	Disordered epitopes as peptide vaccines	2018-04-14		.txt	text/plain	4904	267	44	Disordered proteins represent an important class of antigen in a wide range of human pathogens, and, contrary to widespread belief, they are frequently targets of protective antibody responses. [5] Finally, and perhaps most importantly, peptidebased approaches are limited because the antibody response to many protein antigens is dominated by conformational epitopes, which are difficult or impossible to capture effectively in a peptide-based design. Modified with permission from Ref. 43 Additional specific evidence for affinity maturation in antibodies targeting this epitope comes from recent studies of the antibody responses induced in clinical trials of the RTS,S vaccine, [49] and in the context of natural infection. Although the repetitive sequences in CSP have long been the focus of vaccine development efforts, recent studies have identified epitopes within the conserved N-terminal region that appear to contribute to the protective response to CSP in the context of natural immunity and vaccination.	./cache/cord-023202-0iqhf2o5.txt	./txt/cord-023202-0iqhf2o5.txt