id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-253302-keh7s758	Gong, Danyang	DNA-Packing Portal and Capsid-Associated Tegument Complexes in the Tumor Herpesvirus KSHV	2019-09-05		.txt	text/plain	11190	498	49	Our atomic models of the portal and capsid/CATC, together with visualization of CATCs' variable occupancy and alternate orientation of CATC-interacting vertex triplexes, suggest a mechanism whereby the portal orchestrates procapsid formation and asymmetric long-range determination of CATC attachment during DNA packaging prior to pleomorphic tegumentation/envelopment. Unlike the comparatively high occupancies of capsid-associated tegument proteins in alphaherpesviruses Wang et al., 2018) and betaherpesviruses Yu et al., 2017) , KSHV CATC binding sites are markedly partially and/or more flexibly occupied, leading to poorly resolved CATC structures in prior icosahedral reconstructions of KSHV (Dai et al., 2014 . Thus, to accurately assess the specific occupancy of penton vertex CATCs and to understand the structural basis of a CATC's discriminatory association with portal and penton vertices, we relaxed 5-fold symmetry for penton vertex sub-particles and performed 3D focused classification of their CATC-binding registers ( Figure S1 ).	./cache/cord-253302-keh7s758.txt	./txt/cord-253302-keh7s758.txt