id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-256047-mabrmzd9	Jacomin, Anne-Claire	Deubiquitinating Enzymes Related to Autophagy: New Therapeutic Opportunities?	2018-08-19		.txt	text/plain	9838	516	33	The hydrolysis of ubiquitin linkages is conducted by a specific family of proteases: the DUBs. These enzymes can act at different stages of the protein ubiquitination process: (1) At the "initial" stage, by cleaving the ubiquitin precursors to supply ubiquitin monomers to the ubiquitination enzymes; (2) at the "intermediate" stage, by the regulated removal of ubiquitin moieties from proteins to alter their fate (stabilization, conformational change); and (3) at the "final" stage by the removal of ubiquitin chains from substrates addressed to the proteasome to facilitate their degradation and processing into ubiquitin monomers, free to enter a new ubiquitination cycle ( Figure 2 ) [54] [55] [56] . To date, only a few substrates, known to be directly targeted for degradation by autophagy in response to ubiquitination, have been shown to be regulated by a specific DUB ( Figure 3F ).	./cache/cord-256047-mabrmzd9.txt	./txt/cord-256047-mabrmzd9.txt