id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-261258-yd2p1buu	Acevedo, Orlando A.	Contribution of Fcγ Receptor-Mediated Immunity to the Pathogenesis Caused by the Human Respiratory Syncytial Virus	2019-03-29		.txt	text/plain	6743	289	40	Along these lines, several studies have suggested that antibodies elicited by immunization with FI-hRSV show low neutralizing capacity and promote the formation of immune complexes containing hRSV (hRSV-ICs), which contribute to hRSV pathogenesis through the engagement of Fc gamma receptors (FcγRs) expressed on the surface of immune cells. Along these lines, several studies have suggested that antibodies elicited by immunization with FI-hRSV show low neutralizing capacity and promote the formation of immune complexes containing hRSV (hRSV-ICs), which contribute to hRSV pathogenesis through the engagement of Fc gamma receptors (FcγRs) expressed on the surface of immune cells. Immunization in the mouse model with a recombinant bacillus of Calmette-Guérin (BCG) that expresses the nucleoprotein (N) of hRSV (rBCG-N-hRSV) induce the production of neutralizing antibodies against hRSV and a T helper 1 (Th1) cellular immunity that protects from hRSV associated-lung pathology by decreasing the infiltration of inflammatory immune cells into the lungs and reduce viral loads in the airways of hRSV-infected mice (Bueno et al., 2008; Cautivo et al., 2010; Leyrat et al., 2014) Furthermore, a single low dose of this vaccine produced using current good manufacturing practices (cGMP), conferred protection against hRSV infection in the mouse model (Cespedes et al., 2017) .	./cache/cord-261258-yd2p1buu.txt	./txt/cord-261258-yd2p1buu.txt