id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262036-wig4wdno	Xu, Qi	Sialic acid involves in the interaction between ovomucin and hemagglutinin and influences the antiviral activity of ovomucin	2018-07-30		.txt	text/plain	5173	285	54	As shown in Fig. 1B , the terminal sialic acid was effectively removed in dSA-OVM after enzymatic hydrolysis, and its binding activity was obviously lower than that in the natural OVM. To analyze the role played by free sialic acid in the binding of OVM to HA, further experiments were carried out with different sequences of additions. Based on the above results, it was found that free sialic acid enhances the binding of OVM to influenza virus HA. It is indicating that sialic acid is involved in the binding of OVM to influenza virus, and additional free sialic acid could enhance the OVM antiviral process. The hemagglutinin of the influenza virus recognizes and binds to the ovomucin carbohydrate chain terminal sialic acid, and the interaction is greatly diminished after the sialic acid is removed. The addition of free sialic acid can promote the binding of ovomucin to hemagglutinin and enhance ovomucin anti-influenza virus activity.	./cache/cord-262036-wig4wdno.txt	./txt/cord-262036-wig4wdno.txt