id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-265642-7mu530yp	Syomin, B. V.	Virus-Like Particles as an Instrument of Vaccine Production	2019-06-17		.txt	text/plain	7107	325	41	Using protein expression systems it is possible to produce virus-like particles (VLPs), which are made up of monomers, which are able to multimerize into VLPs, and display the antigenic determinants of target pathogens on their surface. For example, in different laboratories different eukaryotic systems for viral protein expression, including plant cells, are used to produce VLPs which are used for vaccination against the hepatitis C virus (HCV) [36] . Antigen of the duck hepatitis A virus produced in the baculovirus expression system assembles into VLPs immediately in the cultured Spodoptera frugiperda (sf9) cells, while immunization of ducklings with the obtained VLPs induces a high level humoral immune response and protects them from developing the disease [46] . Expression vectors for foreign protein production in plants have been developed based on plant viruses, which allows obtaining plant-producing recombinant viruses or VLPs displaying the target antigen on their surface [101, 102] .	./cache/cord-265642-7mu530yp.txt	./txt/cord-265642-7mu530yp.txt