id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266127-phv08xe2	Mukhopadhyay, Urbi	Biphasic regulation of RNA interference during rotavirus infection by modulation of Argonaute2	2019-08-26		.txt	text/plain	7600	432	46	Consistent to our previous results, Rbx1 expression was successfully knocked down in response to Rbx1 siRNA in RV-SA11-infected cells lysed at 9 hpi as well as in mock-infected control but not in RV-SA11-infected cells harvested FIGURE 1 Host RNA interference is blocked during early hours of RV-SA11 infection. Together, the data suggest that actively replicating RV-SA11 triggers attenuation in protein levels of AGO2 leading to functional blocking of RNAi during early time points (2-6 hpi) of infection. Sensitivity of ectopic GFP (pEGFP-N1) expression to siGFP was also reduced in RV-NSP1overexpressing cells ( Figure S4A ), indicating that RV-NSP1 might FIGURE 3 Rotaviral nonstructural protein 1 triggers ubiquitination and proteasomal degradation of AGO2. Rotavirus nonstructural protein 1 suppresses virus-induced cellular apoptosis to facilitate viral growth by activating the cell survival pathways during early stages of infection	./cache/cord-266127-phv08xe2.txt	./txt/cord-266127-phv08xe2.txt