id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266204-ipa017wz	Poland, G. A.	Personalized vaccinology: A review	2018-08-28		.txt	text/plain	7232	331	36	This has advanced the science beyond that of reductionist scientific approaches by revealing novel interactions between and within the immune system and other biological systems (beyond transcriptional level), which are critical to developing "downstream" adaptive humoral and cellular responses to infectious pathogens and vaccines. A decade ago, we described the idea of vaccinomics and adversomics, based on the immune response network theory [5, 6] , which utilizes immunogenetics/imunogenomics and systems biology approaches to understand the basis for inter-individual variations in vaccineinduced immune responses in humans, as well as the basis for adverse side effects from vaccines [7] . Published data reveal that innate and adaptive immunity is decreased with age, but the systems-level mechanisms for these findings are unclear [66, 68] , particularly in regard to influenza and other viral vaccine responses where the morbidity, mortality, and associated healthcare costs are greater in older individuals [11] .	./cache/cord-266204-ipa017wz.txt	./txt/cord-266204-ipa017wz.txt